People_

Professor David Le Couteur

AO FRACP PhD FAHMS

Professor
Medicine, Concord Clinical School
ANZAC Research Institute
Centre for Education and Research on Ageing

Phone

+61 2 9767 6935

Fax

+61 2 9767 5419

david.lecouteur@sydney.edu.au

Details

Member of The Centre for Drug Discovery Innovation

Member of the Charles Perkins Centre

Biographical details

David Le Couteur is Professor of Geriatric Medicine at the University of Sydney, Senior Staff Specialist Physician in Geriatric Medicine at the Concord RG Hospital in Sydney, and a L3 NHMRC Fellow. In 2016 he was awarded an AO (Officer of the Order of Australia) for distinguished service to medicine as a clinical pharmacologist and geriatrician, particularly through a range of advisory roles and academic research activities. In October 2017 he was elected a fellow of the Australian Academy of Health and Medical Sciences.

Research interests

Biogerontology, Liver and aging, Liver sinusoid and aging, nutrition and aging, geriatric pharmacology

Awards and honours

2023 FASCEPT Fellow of the Australasian Society for Clinical and Experimental Pharmacology and Toxicology

2023 Ruthven Blackburn Medal, University of Sydney

2018 Distinguished Professorial Achievement Award, Faculty of Medicine University of Sydney

2017 Arthur E Mills Oration, RACP

2017 FAHMS Fellow of Australian Academy of Health and Medical Sciences

2016 AO For distinguished service to medicine as a clinical pharmacologist and geriatrician, particularly through a range of advisory roles and academic research activities

2015 Rand Medal, Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists

2014 Don Beaven Travelling Fellowship and Athol Mann Lecturer, Christchurch NZ

2013 William B Abrams award for contribution to geriatric clinical pharmacology, American Society for Clinical Pharmacology and Therapeutics

1996 BMS Career Investigator Award, ANZSGM

1993 RM Gibson Prize, ANZSGM

Themes

Obesity, Diabetes and Cardiovascular Disease, Healthy Ageing, Lifespan

Keywords

Ageing, Hepatology, Pharmacology

Approaches

Aged, Animal Models, Pathology

Clinical speciality

Gerontology

Publications

By Type

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Book Chapters

Wahl, D., Gokarn, R., Solon-Biet, S., Cogger, V., LaRocca, T., Raubenheimer, D., Simpson, S., Le Couteur, D. (2021). Modelling nutrition and brain aging rodents. In Martin CR, Preedy VR, Rajendram R (Eds.), Assessments, Treatments and Modelling in Aging and Neurological Disease: The Neuroscience of Aging, (pp. 517-526). London: Academic Press. [More Information]
Solon-Biet, S., Wahl, D., Raubenheimer, D., Le Couteur, D., Simpson, S., Cogger, V. (2018). A Framework for Uncovering the Roles of Calories and Macronutrients in Health and Aging. In Jeffrey L. Ram, P. Michael Conn (Eds.), Conn's Handbook of Models for Human Aging - Second Edition, (pp. 93-108). London: Academic Press. [More Information]
De Cabo, R., Le Couteur, D. (2015). The Biology of Aging. In D. Kasper, A. Fauci, S. Hauser, D. Longo, J. Jameson, J. Loscalzo (Eds.), Harrison's Principles of Internal Medicine, (pp. 94e1-94e8). Columbus: McGraw-Hill Education.
Le Couteur, D., Naganathan, V., Cogger, V., Simpson, S., De Cabo, R. (2014). Biology of ageing. In Gideon Kaplan (Eds.), Geriatric Medicine: An Introduction, (pp. 3-16). Melbourne: IP Communications.
Naganathan, V., Le Couteur, D. (2014). Prescribing medications to older people. In Gideon Kaplan (Eds.), Geriatric Medicine: An Introduction, (pp. 258-270). Melbourne: IP Communications.
Le Couteur, D., Warren, A., Cogger, V., Bertolino, P. (2014). Ultrastructure of the Liver Sinusoid. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 1235-1240). New York: Springer Science+Business Media. [More Information]
Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers. [More Information]
McMahon, A., Hing, A., Cogger, V., Le Couteur, D. (2011). Animal models of early atherosclerosis: How to translate the data into clinical perspectives. In Petru Liuba (Eds.), Silent Vasculopathy in Childhood: Should Clinicians Care, (pp. 39-63). India: Transworld Research Network.
Everitt, A., Heilbronn, L., Morris, B., Brown-Borg, H., Merry, B., Simpson, S., Varady, K., Masoro, E., Redman, L., Le Couteur, D. (2010). Conclusion: Human Calorie Restriction and Anti-Aging Therapy. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 311-318). Dordrecht: Springer. [More Information]
McLachlan, A., Hilmer, S., Le Couteur, D. (2010). Dosing Errors: Age-Related Changes in Pharmacokinetics. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 127-135). New York: Springer Science+Business Media. [More Information]
Everitt, A., Heilbronn, L., Le Couteur, D. (2010). Food Intake, Life Style, Aging and Human Longevity. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 15-41). Dordrecht: Springer. [More Information]
Everitt, A., Brown-Borg, H., Le Couteur, D., Bartke, A. (2010). Food Restriction, Hormones, Genes and Aging. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 217-318). Dordrecht: Springer. [More Information]
Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer. [More Information]
Le Couteur, D., Kendig, H., Naganathan, V., McLachlan, A. (2010). The Ethics of Prescribing Medications to Older People. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 29-42). New York: Springer Science+Business Media. [More Information]
Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.
Le Couteur, D., Naganathan, V., Cogger, V., Cumming, R., McLean, A. (2006). Pharmacotherapy in the elderly: clinical issues and perspectives. In Kohli K, Gupta M, Tejwani S. (Eds.), In Contemporary Perspectives on Clinical Pharmacotherapeutics, (pp. 709-722). New Dehli: Elsevier.

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Journals

Hilmer, S., Schwartz, J., Petrovic, M., Walker, L., Thürmann, P., Le Couteur, D. (2024). Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee. Journal of the American Geriatrics Society. [More Information]
Luong, R., Ribeiro, R., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Seibel, M., Hirani, V. (2024). Cross-sectional and longitudinal associations between empirically derived dietary patterns and frailty among older men: The Concord Health and Ageing in Men Project. Journal of Nutrition, Health and Aging, 28(1), 100021. [More Information]
Luong, R., Ribeiro, R., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Seibel, M., Hirani, V. (2024). Empirically derived dietary patterns are associated with major adverse cardiovascular events, all-cause mortality, and congestive cardiac failure in older men: The Concord Health and Ageing in Men Project. Journal of Nutrition, Health and Aging, 28(2), 100020. [More Information]
Tran, M., Van Zwieten, A., Kiely, K., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Seibel, M., Waite, L., Cumming, R., Khalatbari Soltani, S. (2024). Intra-generational social mobility and mortality among older men in the Concord Health and Ageing in Men Project: A cohort study. SSM - Population Health, 25, 101581. [More Information]
Hunt, N., Lockwood, G., Heffernan, S., Daymond, J., Ngu, M., Narayanan, R., Westwood, L., Mohanty, B., Esser, L., Williams, C., Kuncic, Z., McCourt, P., Le Couteur, D., Cogger, V. (2024). Oral nanotherapeutic formulation of insulin with reduced episodes of hypoglycaemia. Nature Nanotechnology, 19(4), 534-544. [More Information]
Ribeiro, R., Senior, A., Simpson, S., Tan, J., Raubenheimer, D., Le Couteur, D., Macia, L., Holmes, A., Eberhard, J., O'Sullivan, J., Koay, Y., Kanjrawi, A., Yang, J., Kim, T., Gosby, A. (2024). Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial. Aging Cell, 23(11), e14276. [More Information]
Lockwood, G., Hunt, N., Kockx, M., Kang, S., Le Couteur, D., Cogger, V. (2024). Understanding the Liver’s Role in the Clearance of Aβ40. Livers, 4(2), 253-267. [More Information]
Luong, R., Ribeiro, R., Hirani, V., Simpson, S., Le Couteur, D., Raubenheimer, D., Gosby, A. (2023). Associations between protein to non-protein ratio and intakes of other dietary components in a cohort aged 65–75 years: the Nutrition for Healthy Living Study. Public Health Nutrition, 26(12), 3023-3037. [More Information]
Das, S., Silver, R., Senior, A., Gilhooly, C., Bhapkar, M., Le Couteur, D. (2023). Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification. Aging Cell, 22(12), e14018. [More Information]
Mao, H., Szafranska, K., Kruse, L., Holte, C., Wolfson, D., Ahluwalia, B., Whitchurch, C., Cole, L., Lockwood, G., Diekmann, R., Le Couteur, D., Cogger, V., McCourt, P. (2023). Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure. Scientific Reports, 13(1). [More Information]
Luong, R., Ribeiro, R., Rangan, A., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Seibel, M., Hirani, V. (2023). Haem Iron Intake Is Associated with Increased Major Adverse Cardiovascular Events, All-Cause Mortality, Congestive Cardiac Failure, and Coronary Revascularisation in Older Men: The Concord Health and Ageing in Men Project. Journal of Nutrition, Health and Aging, 27(7), 559-570. [More Information]
Kiely, K., Khalatbari Soltani, S., Blyth, F., Naganathan, V., Handelsman, D., Waite, L., Le Couteur, D., Mortby, M., Cumming, R., Anstey, K. (2023). Mixed Evidence of an Association between Self-Rated Hearing Difficulties and Falls: Prospective Analysis of Two Longitudinal Studies. Gerontology, 69(1), 98-108. [More Information]
Scott, D., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Waite, L., Hirani, V. (2023). Sarcopenia prevalence and functional outcomes in older men with obesity: Comparing the use of the EWGSOP2 sarcopenia versus ESPEN-EASO sarcopenic obesity consensus definitions. Clinical Nutrition, 42(9), 1610-1618. [More Information]
Wu, L., Das, A., Massudi, H., Li, C., Kim, L., Wong, A., Marinova, M., Sultani, G., Das, A., Youngson, N., Le Couteur, D., et al (2023). SIRT2 transgenic over-expression does not impact lifespan in mice. Aging Cell, 22(12), e14027. [More Information]
Solon-Biet, S., Clark, X., Bell-Anderson, K., Rusu, P., Perks, R., Freire, T., Pulpitel, T., Senior, A., Hoy, A., Aung, O., Le Couteur, D., Raubenheimer, D., Conigrave, A., Simpson, S., et al (2023). Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure. Cell Reports, 42(12). [More Information]
Hilmer, S., Lo, S., Kelly, P., Viney, R., Blyth, F., Le Couteur, D., McLachlan, A., Arora, S., Hossain, L., Gnjidic, D. (2023). Towards Optimizing Hospitalized Older adults' MEdications (TO HOME): Multi-centre study of medication use and outcomes in routine care. British Journal of Clinical Pharmacology. [More Information]
Eberhard, J., Ruiz, K., Tan, J., Vidanelage, T., Khan, S., Inan Eroglu, E., Adler, C., Simpson, S., Le Couteur, D., Raubenheimer, D., Macia, L., Gosby, A., Ribeiro, R. (2022). A randomized clinical trial to investigate the effect of dietary protein sources on periodontal health. Journal of Clinical Periodontology, 49(4), 388-400. [More Information]
Raubenheimer, D., Senior, A., Mirth, C., Cui, Z., Hou, R., Le Couteur, D., Solon-Biet, S., Léopold, P., Simpson, S. (2022). An integrative approach to dietary balance across the life course. iScience, 25(5). [More Information]
Dai-Keller, Z., Hirani, V., Sahni, S., Felson, D., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Seibel, M., Waite, L., Cumming, R., et al (2022). Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutrition and Health, 28(2), 229-238. [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Ribeiro, R., Simpson, S., Hirani, V. (2022). Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. Journal of Human Nutrition and Dietetics, 35(5), 845-860. [More Information]
Le Couteur, D., Anderson, R., de Cabo, R. (2022). Can we make drug discovery targeting fundamental mechanisms of aging a reality? Expert Opinion on Drug Discovery, 17(2), 97-100. [More Information]
Luong, R., Ribeiro, R., Rangan, A., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Le Couteur, D., Hirani, V. (2022). Changes in Dietary Total and Nonheme Iron Intake Is Associated With Incident Frailty in Older Men: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 77(9), 1853-1865. [More Information]
Khalatbari Soltani, S., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Seibel, M., Hirani, V., Wright, F., Waite, L., Cumming, R. (2022). Cohort Profile Update: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology, 51(1), 31-32H. [More Information]
Wu, H., Mach, J., Gnjidic, D., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Hilmer, S. (2022). Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Aging Research. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 77(7), 1295-1303. [More Information]
Ischia, L., Naganathan, V., Waite, L., Le Couteur, D., Thillainadesan, J. (2022). COVID-19 and geriatric medicine in Australia and New Zealand. Australasian Journal on Ageing, 41(2), 301-308. [More Information]
Chow, E., Hsu, B., Waite, L., Blyth, F., Handelsman, D., Le Couteur, D., Naganathan, V., Stanaway, F. (2022). Diagnostic accuracy of linked administrative data for dementia diagnosis in community-dwelling older men in Australia. BMC Geriatrics, 22(1). [More Information]
Le Couteur, D., Raubenheimer, D., Solon-Biet, S., de Cabo, R., Simpson, S. (2022). Does diet influence aging? Evidence from animal studies. Journal of Internal Medicine. [More Information]
Shu, C., Wright, F., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Stanaway, F. (2022). Does social support predict increased use of dental services in older men? Australian Dental Journal, 67(3), 262-270. [More Information]
Le Couteur, D., Flicker, L., Hilmer, S. (2022). Geriatric medicine and health care for older people in Australia. Age and Ageing, 51(3), 1-4. [More Information]
Gnanenthiran, S., Ng, A., Cumming, R., Brieger, D., Le Couteur, D., Waite, L., Seibel, M., Handelsman, D., Naganathan, V., Kritharides, L., Blyth, F. (2022). Hemoglobin, Frailty, and Long-term Cardiovascular Events in Community-Dwelling Older Men Aged ≥ 70 Years. Canadian Journal of Cardiology, 38(6), 745-753. [More Information]
Solon-Biet, S., Griffiths, L., Fosh, S., Le Couteur, D., Simpson, S., Senior, A. (2022). Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents. BMC Biology, 20(1), 19. [More Information]
Senior, A., Legault, V., Lavoie, F., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D., Simpson, S., Cohen, A. (2022). Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology, 20(1), Article 196-17 pages. [More Information]
Hunt, N., McCourt, P., Kuncic, Z., Le Couteur, D., Cogger, V. (2022). Opportunities and Challenges for Nanotherapeutics for the Aging Population. Global Journal of Emerging Market Economies, 4, 832524. [More Information]
Mach, J., Allore, H., Gnjidic, D., Gemikonakli, G., Kane, A., Howlett, S., de Cabo, R., Le Couteur, D., Hilmer, S. (2022). Preclinical frailty assessments: Phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications. Experimental Gerontology, 161, 111700. [More Information]
Xu, P., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., Seibel, M., Le Couteur, D., Waite, L., Khalatbari Soltani, S. (2022). Socioeconomic Inequalities in Elective and Nonelective Hospitalizations in Older Men. JAMA Network Open, 5(4), e226398. [More Information]
Hunt, N., Wahl, D., Westwood, L., Lockwood, G., Le Couteur, D., Cogger, V. (2022). Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics. Advanced Drug Delivery Reviews, 190. [More Information]
Le Couteur, D., Thillainadesan, J. (2022). What Is an Aging-Related Disease? An Epidemiological Perspective. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 77(11), 2168-2174. [More Information]
Thillainadesan, J., Le Couteur, D., Haq, I., Wilkinson, T. (2022). When I say … microlearning. Medical Education, 56(8), 791-792. [More Information]
Takehara, S., Wright, F., Naganathan, V., Hirani, V., Blyth, F., Le Couteur, D., Waite, L., Seibel, M., Handelsman, D., Cumming, R. (2021). A Cross-Sectional Study of Perceived Dental Treatment Needs and Oral Health Status in Community-Dwelling Older Australian Men: The Concord Health and Ageing in Men Project. International Dental Journal, 71(3), 224-232. [More Information]
Cervo, M., Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Ribeiro, R., Waite, L., Hirani, V. (2021). Adherence to Mediterranean diet and its associations with circulating cytokines, musculoskeletal health and incident falls in community-dwelling older men: The Concord Health and Ageing in Men Project. Clinical Nutrition, 40(12), 5753-5763. [More Information]
Takehara, S., Hirani, V., Wright, F., Naganathan, V., Blyth, F., Le Couteur, D., Waite, L., Seibel, M., Handelsman, D., Cumming, R. (2021). Appetite, oral health and weight loss in community-dwelling older men: an observational study from the Concord Health and Ageing in Men Project (CHAMP). BMC Geriatrics, 21(1), 1-9. [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Ribeiro, R., Simpson, S., Hirani, V. (2021). Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project. Public Health Nutrition, 24(14), 4490-4505. [More Information]
Milledge, K., Cumming, R., Wright, F., Naganathan, V., Blyth, F., Le Couteur, D., Waite, L., Handelsman, D., Hirani, V. (2021). Associations between the composition of functional tooth units and nutrient intake in older men: The Concord Health and Ageing in Men Project. Public Health Nutrition, 24(18), 6335-6345. [More Information]
Wali, J., Raubenheimer, D., Senior, A., Le Couteur, D., Simpson, S. (2021). Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry. Cardiovascular Research, 117(2), 386-401. [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Ribeiro, R., Waite, L., Simpson, S., Hirani, V. (2021). Changes in micronutrient intake and factors associated with this change among older Australian men: The Concord Health and Ageing in Men Project. Public Health Nutrition, 24(14), 4454-4465. [More Information]
Mach, J., Gemikonakli, G., Logan, C., Wyk, B., Allore, H., Ekambareshwar, S., Kane, A., Howlett, S., de Cabo, R., Le Couteur, D., Hilmer, S. (2021). Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(6), 1010-1018. [More Information]
Ng, B., Duong, M., Lo, S., Le Couteur, D., Hilmer, S. (2021). Deprescribing perceptions and practice reported by multidisciplinary hospital clinicians after, and by medical students before and after, viewing an e-learning module. Research in Social and Administrative Pharmacy, 17(11), 1997-2005. [More Information]
Hilmer, S., Petrovic, M., Le Couteur, D., Schwartz, J., Thuermann, P. (2021). Development, evaluation and use of COVID-19 vaccines in older adults: Preliminary principles for the pandemic and beyond. British Journal of Clinical Pharmacology, 87(9), 3459-3461. [More Information]
Stanaway, F., Ribeiro, R., Khalatbari Soltani, S., Cvejic, E., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D., Simpson, S., Waite, L., Cumming, R., Hirani, V. (2021). Diet quality in an ethnically diverse population of older men in Australia. European Journal of Clinical Nutrition, 51(1). [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Ribeiro, R., Simpson, S., Hirani, V. (2021). Dietary and supplemental antioxidant intake and risk of major adverse cardiovascular events in older men: The concord health and ageing in men project. Nutrition, Metabolism & Cardiovascular Diseases, 31(4), 1102-1112. [More Information]
Ng, C., Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Waite, L., Handelsman, D., Hirani, V. (2021). Higher-Impact Physical Activity Is Associated With Maintenance of Bone Mineral Density But Not Reduced Incident Falls or Fractures in Older Men: The Concord Health and Aging in Men Project. Journal of Bone and Mineral Research, 36(4), 662-672. [More Information]
Wali, J., Milner, A., Luk, A., Pulpitel, T., Dodgson, T., Facey, H., Wahl, D., Kebede, M., Senior, A., Sullivan, M., Brandon, A., Yau, B., Lockwood, G., Koay, Y., Ribeiro, R., Solon-Biet, S., Bell-Anderson, K., O'Sullivan, J., Macia, L., Cooney, G., Cogger, V., Holmes, A., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3(6), 810-828. [More Information]
Duong, M., McLachlan, A., Bennett, A., Jokanovic, N., Le Couteur, D., Baysari, M., Gnjidic, D., Blyth, F., Hilmer, S. (2021). Iterative Development of Clinician Guides to Support Deprescribing Decisions and Communication for Older Patients in Hospital: A Novel Methodology. Drugs and Aging, 38(1), 75-87. [More Information]
Fotheringham, A., Solon-Biet, S., Bielefeldt-Ohmann, H., McCarthy, D., McMahon, A., Ruohonen, K., Li, I., Sullivan, M., Whiddett, R., Borg, D., Cogger, V., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2021). Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 24(11), 103308. [More Information]
Hew, J., Parugano, R., Mooney, C., Smyth, J., Kim, S., Tsai, K., Chong, C., Chan, R., Attia, B., Nicholls, C., Li, Z., Solon-Biet, S., Le Couteur, D., Simpson, S., Maitz, P., Wang, Y., et al (2021). Low-protein diet accelerates wound healing in mice post-acute injury. Burns & Trauma, 9, tkab010. [More Information]
Wu, H., Le Couteur, D., Hilmer, S. (2021). Mortality trends of stroke and dementia: Changing landscapes and new challenges. Journal of the American Geriatrics Society, 69(10), 2888-2898. [More Information]
Wu, H., Mach, J., Le Couteur, D., Hilmer, S. (2021). Nationwide mortality trends of delirium in Australia and the United States from 2006 to 2016. Australasian Journal on Ageing, 40(4), e279-e286. [More Information]
Le Couteur, D., Solon-Biet, S., Parker, B., Pulpitel, T., Brandon, A., Hunt, N., Wali, J., Gokarn, R., Senior, A., Cooney, G., Raubenheimer, D., James, D., Simpson, S., et al (2021). Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin. Cell Metabolism, 33(12), 2367-2379.e4. [More Information]
Wu, H., Mach, J., Gemikonakli, G., Tran, T., Allore, H., Gnjidic, D., Howlett, S., de Cabo, R., Le Couteur, D., Hilmer, S. (2021). Polypharmacy Results in Functional Impairment in Mice: Novel Insights into Age and Sex Interations. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(10), 1748-1756. [More Information]
Wu, H., Mach, J., Le Couteur, D., Hilmer, S. (2021). Prevalence and risk factors of food insecurity among Libyan migrant families in Australia. BMC Public Health, 21(1), 2156. [More Information]
Scott, D., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Seibel, M., Waite, L., Hirani, V. (2021). Prospective associations of chronic and intrusive pain with sarcopenia and physical disability amongst older Australian men: The Concord Health and Ageing in Men Project. Experimental Gerontology, 153, 111501. [More Information]
Hunt, N., Lockwood, G., Kang, S., Westwood, L., Limantoro, C., Chrzanowski, W., McCourt, P., Kuncic, Z., Le Couteur, D., Cogger, V. (2021). Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice. ACS Nano, 15(3), 4710-4727. [More Information]
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Das, A., Cumming, R., Naganathan, V., Ribeiro, R., Le Couteur, D., Handelsman, D., Waite, L., Hirani, V. (2021). The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project. European Journal of Nutrition, 60(1), 443-454. [More Information]
Khalatbari Soltani, S., Cumming, R., Chomik, R., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D., Waite, L., Stanaway, F. (2021). The association between home ownership and the health of older men: Cross-sectional analysis of the Australian Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 40(3), e199-e206. [More Information]
Khalatbari Soltani, S., Stanaway, F., Sherrington, C., Blyth, F., Naganathan, V., Handelsman, D., Seibel, M., Waite, L., Le Couteur, D., Cumming, R. (2021). The Prospective Association Between Socioeconomic Status and Falls Among Community-Dwelling Older Men. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(10), 1821-1828. [More Information]
Scott, D., Hirani, V., Waite, L., Blyth, F., Le Couteur, D., Cumming, R., Jones, G. (2021). ‘Giant’ Claims Require Strong Evidence: A Comment on ‘Osteosarcopenia: A Geriatric Giant of the XXI Century’. Journal of Nutrition, Health and Aging, 25(7), 946-947. [More Information]
Johansen, M., Irving, A., Montagutelli, X., Tate, M., Rudloff, I., Nold, M., Hansbro, N., Kim, R., Donovan, C., Liu, G., McCaughan, G., Gorrell, M., Cole, A., Moreno, C., Le Couteur, D., Hesselson, D., Triccas, J., Neely, G., Gamble, J., Simpson, S., et al (2020). Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology, 13(6), 877-891. [More Information]
Wahl, D., Anderson, R., Le Couteur, D. (2020). Antiaging Therapies, Cognitive Impairment, and Dementia. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(9), 1643-1652. [More Information]
Le Couteur, D., Stanaway, F., Waite, L., Cullen, J., Lindley, R., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D. (2020). Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(10), 1858-1862. [More Information]
Wright, F., Takehara, S., Stanaway, F., Naganathan, V., Blyth, F., Hirani, V., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M., Cumming, R. (2020). Associations between oral health and depressive symptoms: Findings from the Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 39(3), e306-e314. [More Information]
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Hsu, B., Waite, L., Hirani, V. (2020). Associations of Body Composition Trajectories with Bone Mineral Density, Muscle Function, Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(5), 939-945. [More Information]
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Handelsman, D., Desai, R., Seibel, M., Le Couteur, D., Cumming, R. (2020). Circulating Sex Steroid Measurements of Men by Mass Spectrometry Are Highly Reproducible after Prolonged Frozen Storage. Journal of Steroid Biochemistry and Molecular Biology, 197, 105528. [More Information]
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Hsu, B., Waite, L., Hirani, V. (2020). Comparison of clinical risk factors for incident fracture in obese and non-obese community-dwelling older men. Bone, 137, 1-9. [More Information]
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Le Couteur, D., Anderson, R., Newman, A. (2020). COVID-19 Through the Lens of Gerontology. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(9), e119-e120. [More Information]
Bernier, M., Mitchell, S., Wahl, D., Diaz, A., Singh, A., Seo, W., Wang, M., Ali, A., Kaiser, T., Price, N., Warren, A., Harney, D., Koay, Y., Mach, J., Pulpitel, T., O'Sullivan, J., Larance, M., Le Couteur, D., Cogger, V., et al (2020). Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell Metabolism, 32(2), 203-214.e4. [More Information]
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Wu, H., Mach, J., Le Couteur, D., Hilmer, S. (2020). Fall-related mortality trends in Australia and the United Kingdom: Implications for research and practice. Maturitas, 142, 68-72. [More Information]
Hsu, B., Naganathan, V., Blyth, F., Hirani, V., Le Couteur, D., Waite, L., Seibel, M., Handelsman, D., Cumming, R. (2020). Frailty and Cause-Specific Hospitalizations in Community-Dwelling Older Men. Journal of Nutrition, Health and Aging, 24(6), 563-569. [More Information]
Valdez, E., Wright, F., Naganathan, V., Milledge, K., Blyth, F., Hirani, V., Le Couteur, D., Handelsman, D., Waite, L., Cumming, R. (2020). Frailty and oral health: Findings from the Concord Health and Ageing in Men Project. Gerodontology, 37(1), 28-37. [More Information]
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Tsai, K., Shi, H., Ma, D., Nicholls, C., PublicationsHarvesting, T., Solon-Biet, S., D'Souza, M., Le Couteur, D., Simpson, S., Maitz, P., Wang, Y. (2020). Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice. British Journal of Nutrition, 123(9), 1056-1067. [More Information]
Hide, D., Warren, A., Fernández-Iglesias, A., Maeso-Díaz, R., Peralta, C., Le Couteur, D., Bosch, J., Cogger, V., Gracia-Sancho, J. (2020). Ischemia/reperfusion injury in the aged liver: The importance of the sinusoidal endothelium in developing therapeutic strategies for the elderly. Heart, Lung, and Circulation, 75(2), 268-277. [More Information]
Gnanenthiran, S., Ng, A., Cumming, R., Brieger, D., Le Couteur, D., Waite, L., Handelsman, D., Naganathan, V., Kritharides, L., Blyth, F. (2020). Low total cholesterol is associated with increased major adverse cardiovascular events in men aged >70 years not taking statins. Heart, 106(9), 698-705. [More Information]
Stanaway, F., Blyth, F., Naganathan, V., Le Couteur, D., Ribeiro, R., Hirani, V., Waite, L., Handelsman, D., Seibel, M., Cumming, R. (2020). Mortality Paradox of Older Italian-Born Men in Australia: The Concord Health and Ageing in Men Project. Journal of Immigrant and Minority Health, 22(1), 102-109. [More Information]
Bertoldo, M., Listijono, D., Ho, W., Riepsamen, A., Goss, D., Richani, D., Jin, X., Mahbub, S., Campbell, J., Habibalahi, A., Le Couteur, D., et al (2020). NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell Reports, 30(6), 1670-1681. [More Information]
Cumming, R., Khalatbari Soltani, S., Blyth, F., Naganathan, V., Le Couteur, D. (2020). Not all older men have the chronic diseases associated with severe COVID-19. Australasian Journal on Ageing, 39(4), 381-382. [More Information]
Takehara, S., Wright, F., Waite, L., Naganathan, V., Hirani, V., Blyth, F., Le Couteur, D., Seibel, M., Handelsman, D., Cumming, R. (2020). Oral health and cognitive status in the Concord Health and Ageing in Men Project: A cross-sectional study in community-dwelling older Australian men. Gerodontology, 37(4), 353-360. [More Information]
Ford, G., Lord, J., Ferguson, M., Bountra, C., Le Couteur, D. (2020). Organizational innovation for developing new medicines that target aging and age-related conditions. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(1), 87-88. [More Information]
Cervo, M., Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Ribeiro, R., Waite, L., Hirani, V., et al (2020). Proinflammatory Diet Increases Circulating Inflammatory Biomarkers and Falls Risk in Community-Dwelling Older Men. The Journal of Nutrition, 150(2), 373-381. [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Ribeiro, R., Le Couteur, D., Handelsman, D., Waite, L., Simpson, S., Hirani, V. (2020). Prospective Associations Between Dietary Antioxidant Intake and Frailty in Older Australian Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(2), 348-356. [More Information]
Hunt, N., Lockwood, G., Le Couteur, F., McCourt, P., Singla, N., Kang, S., Burgess, A., Kuncic, Z., Le Couteur, D., Cogger, V. (2020). Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots. ACS Nano, 14(2), 1492-1507. [More Information]
Freire, T., Senior, A., Perks, R., Pulpitel, T., Clark, X., Brandon, A., Wahl, D., Hatchwell, L., Le Couteur, D., Cooney, G., Larance, M., Simpson, S., Solon-Biet, S. (2020). Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice. Journal of Physiology, 598(11), 2081-2092. [More Information]
Khalatbari Soltani, S., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D., Seibel, M., Waite, L., Cvejic, E., Cumming, R. (2020). Socioeconomic status, health-related behaviours, and death among older people: The Concord health and aging in men project prospective cohort study. BMC Geriatrics, 20(1), 261. [More Information]
Hunt, N., Lockwood, G., Kang, S., Pulpitel, T., Clark, X., Mao, H., McCourt, P., Cooney, G., Wali, J., Le Couteur, F., Le Couteur, D., Cogger, V. (2020). The effects of metformin on age-related changes in the liver sinusoidal endothelial cell. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(2), 278-285. [More Information]
Wahl, D., Solon-Biet, S., Cogger, V., Fontana, L., Simpson, S., Le Couteur, D., Ribeiro, R. (2019). Aging, lifestyle and dementia. Neurobiology of Disease, 130, 1-15. [More Information]
Thomas, R., Sims, R., Beller, E., Scott, A., Doust, J., Le Couteur, D., Pond, D., Loy, C., Forlini, C., Glasziou, P. (2019). An Australian community jury to consider case-finding for dementia: Differences between informed community preferences and general practice guidelines. Health Expectations, 22(3), 475-484. [More Information]
Narayan, S., Pearson, S., Litchfield, M., Le Couteur, D., Buckley, N., McLachlan, A., Zoega, H. (2019). Anticholinergic medicines use among older adults before and after initiating dementia medicines. British Journal of Clinical Pharmacology, 85(9), 1957-1963. [More Information]
Solon-Biet, S., Cogger, V., Pulpitel, T., Wahl, D., Clark, X., Bagley, E., Gregoriou, G., Senior, A., Wang, Q., Brandon, A., Perks, R., O'Sullivan, J., Koay, Y., Bell-Anderson, K., Kebede, M., Yau, B., Atkinson, C., Dodgson, T., Wali, J., Raubenheimer, D., Cooney, G., Le Couteur, D., Simpson, S., et al (2019). Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism, 1(5), 532-545. [More Information]
Shu, C., Hsu, B., Cumming, R., Blyth, F., Waite, L., Le Couteur, D., Handelsman, D., Naganathan, V. (2019). Caregiving and all-cause mortality in older men 2005-15: the Concord Health and Ageing in Men Project. Age and Ageing, 48(4), 571-576. [More Information]
Wahl, D., Gokarn, R., Mitchell, S., Solon-Biet, S., Cogger, V., Simpson, S., Le Couteur, D., de Cabo, R. (2019). Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. Nutrition and Healthy Aging, 5(2), 111-117. [More Information]
Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., de Cabo, R., Jones, B., Hilmer, S. (2019). Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(3), 332. [More Information]
Mao, H., Diekmann, R., Liang, H., Cogger, V., Le Couteur, D., Lockwood, G., Hunt, N., Schuttpelz, M., Huser, T., Chen, V., et al (2019). Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets. Nanophotonics, 8(7), 1299-1313. [More Information]
Hsu, B., Hirani, V., Cumming, R., Naganathan, V., Blyth, F., Wright, F., Waite, L., Seibel, M., Handelsman, D., Le Couteur, D. (2019). Cross-sectional and Longitudinal Relationships between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: the Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(6), 835-841. [More Information]
Gaddam, R., Chambers, S., Fraser, R., Cogger, V., Le Couteur, D., Ishii, I., Bhatia, M. (2019). Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis. International Journal of Molecular Sciences, 20(13), 1-9. [More Information]
Baysari, M., Duong, M., Zheng, W., Nguyen, A., Lo, S., Ng, B., Ritchie, A., Le Couteur, D., McLachlan, A., Bennett, A., Hilmer, S. (2019). Delivering the right information to the right person at the right time to facilitate deprescribing in hospital: a mixed methods multisite study to inform decision support design in Australia. BMJ Open, 9(9), 1-9. [More Information]
Wali, J., Milner, A., Pulpitel, T., Koay, Y., Brandon, A., Kebede, M., Dodgson, T., O'Sullivan, M., Wahl, D., Yau, B., O'Sullivan, J., Solon-Biet, S., Cooney, G., Cogger, V., Le Couteur, D., Simpson, S., et al (2019). Determining the metabolic impact of dietary carbohydrate composition in the setting of low, medium and high protein diets. Obesity Research & Clinical Practice, 13(3), 296. [More Information]
Jokanovic, N., Aslani, P., Carter, S., Duong, M., Gnjidic, D., Jansen, J., Le Couteur, D., Hilmer, S. (2019). Development of consumer information leaflets for deprescribing in older hospital inpatients: A mixed-methods study. BMJ Open, 9(12), 1-18. [More Information]
Senior, A., Solon-Biet, S., Cogger, V., Le Couteur, D., Nakagawa, S., Raubenheimer, D., Simpson, S. (2019). Dietary macronutrient content, age-specific mortality and lifespan. Proceedings of the Royal Society B: Biological Sciences, 286(1902), 1-9. [More Information]
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Hirani, V. (2019). Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(6), 827-834. [More Information]
Scott, I., Hilmer, S., Le Couteur, D. (2019). Going Beyond the Guidelines in Individualising the Use of Antihypertensive Drugs in Older Patients. Drugs and Aging, 36(8), 675-685. [More Information]
Hunt, N., Kang, S., Lockwood, G., Le Couteur, D., Cogger, V. (2019). Hallmarks of Aging in the Liver. Computational and Structural Biotechnology Journal, 17, 1151-1161. [More Information]
Kashyap, M., Thuermann, P., Le Couteur, D., Abernathy, D., Hilmer, S. (2019). IUPHAR International geriatric clinical pharmacology curriculum for medical students. Pharmacological Research, 141, 611-615. [More Information]
Hunt, N., Lockwood, G., Warren, A., Mao, H., McCourt, P., Le Couteur, D., Cogger, V. (2019). Manipulating fenestrations in young and old liver sinusoidal endothelial cells. American Journal of Physiology: Gastrointestinal and Liver Physiology, 316(1), G144-G154. [More Information]
Kang, S., Cogger, V., Le Couteur, D., Fu, D. (2019). Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes. American Journal of Physiology: Cell Physiology, 317(5), C942-C952. [More Information]
Ribeiro, R., Solon-Biet, S., Pulpitel, T., Senior, A., Cogger, V., Clark, X., O'Sullivan, J., Koay, Y., Hirani, V., Blyth, F., Seibel, M., Naganathan, V., Cumming, R., Handelsman, D., Simpson, S., Le Couteur, D., et al (2019). Of older mice and men: Branched-chain amino acids and body composition. Nutrients, 11(8), 1-11. [More Information]
Tran, J., Wright, F., Takara, S., Shu, C., Chu, S., Naganathan, V., Hirani, V., Blyth, F., Le Couteur, D., Waite, L., Handelsman, D., Seibel, M., Milledge, K., Cumming, R. (2019). Oral health behaviours of older Australian men: the Concord Health and Ageing in Men Project. Australian Dental Journal, 64(3), 246-255. [More Information]
Morimoto, J., Senior, A., Ruiz, K., Wali, J., Pulpitel, T., Solon-Biet, S., Cogger, V., Raubenheimer, D., Le Couteur, D., Simpson, S., Eberhard, J. (2019). Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS One, 14(3), 1-10. [More Information]
Simpson, S., Le Couteur, D. (2019). The diet and the damage done. Nature Metabolism, 1(11), 1030-1031. [More Information]
Ribeiro, R., Simpson, S., Le Couteur, D., Raubenheimer, D., Eberhard, J., Ruiz, K., Macia, L., Todorova, Y., Gosby, A. (2019). The nutrition for healthy living study: A randomised clinical trial assessing the effect of protein sources on healthy ageing. Nutrition and Healthy Aging, 5(1), 43-51. [More Information]
Le Couteur, D., Simpson, S. (2018). 90th Anniversary Commentary: Caloric Restriction Effects on Aging. The Journal of Nutrition, 148(10), 1656-1659. [More Information]
Zunzarren Megale, R., Ferreira, M., Ferreira, P., Naganathan, V., Cumming, R., Hirani, V., Waite, L., Seibel, M., Le Couteur, D., Handelsman, D., Blyth, F. (2018). Association between pain and the frailty phenotype in older men: Longitudinal results from the Concord Health and Ageing in Men Project (CHAMP). Age and Ageing, 47(3), 381-387. [More Information]
Nishtala, P., Chyou, T., Held, F., Le Couteur, D., Gnjidic, D. (2018). Association rules method and big data: Evaluating frequent medication combinations associated with fractures in older adults. Pharmacoepidemiology and Drug Safety, 27(10), 1123-1130. [More Information]
Nair-Shalliker, V., Eager, S., Chrzanowska, A., Mason, R., Waite, L., Le Couteur, D., Seibel, M., Handelsman, D., Cumming, R., Smith, D., Armstrong, B. (2018). Associations between sun sensitive pigmentary genes and serum prostate specific antigen levels. PloS One, 13(3), 1-12. [More Information]
Scott, D., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Seibel, M., Waite, L., Hirani, V. (2018). Associations of sarcopenic obesity with the metabolic syndrome and insulin resistance over five years in older men: The Concord Health and Ageing in Men Project. Experimental Gerontology, 108, 99-105. [More Information]
Hsu, B., Bleicher, K., Waite, L., Naganathan, V., Blyth, F., Handelsman, D., Le Couteur, D., Seibel, M., Cumming, R. (2018). Community-dwelling older men with dementia are at high risk of hip fracture, but not any other fracture: The Concord Health and Aging in Men Project. Geriatrics and Gerontology International, 18(10), 1479-1484. [More Information]
Wahl, D., Solon-Biet, S., Wang, K., Wali, J., Pulpitel, T., Clark, X., Raubenheimer, D., Senior, A., Sinclair, D., Cooney, G., Cogger, V., Simpson, S., Le Couteur, D., et al (2018). Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Reports, 25(8), 2234-2243.e6. [More Information]
Ng, B., Le Couteur, D., Hilmer, S. (2018). Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients. Drugs & Aging, 35(6), 493-521. [More Information]
Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Le Couteur, D., Seibel, M., Handelsman, D. (2018). Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(6), 729-736. [More Information]
Wahl, D., Bernier, M., Simpson, S., de Cabo, R., Le Couteur, D. (2018). Future directions of resveratrol research. Nutrition and Healthy Aging, 4(4), 287-290. [More Information]
Le Couteur, D., Bateman, B., Brayne, C. (2018). Idalopirdine: Another disappointment for people with dementia. BMJ, 360, 1-2. [More Information]
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Noguchi, N., Chan, L., Cumming, R., Blyth, F., Handelsman, D., Waite, L., Le Couteur, D., Naganathan, V. (2018). Natural history of post-void residual urine volume over 5 years in community-dwelling older men: The Concord Health and Ageing in Men Project. Neurourology and Urodynamics, 37(3), 1068-1073. [More Information]
Hunt, N., McCourt, P., Le Couteur, D., Cogger, V. (2018). Novel targets for delaying aging: The importance of the liver and advances in drug delivery. Advanced Drug Delivery Reviews, 135, 39-49. [More Information]
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Le Couteur, D., Anderson, R., De Cabo, R. (2018). Sex and aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(2), 139-140. [More Information]
Hsu, B., Hirani, V., Waite, L., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Cumming, R., Handelsman, D. (2018). Temporal associations between sexual function and cognitive function in community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 47(6), 900-904. [More Information]
Solon-Biet, S., Wahl, D., Raubenheimer, D., Cogger, V., Le Couteur, D., Simpson, S. (2018). The geometric framework: An approach for studying the impact of nutrition on healthy aging. Drug Discovery Today: Disease Models, 27, 61-68. [More Information]
Simpson, S., Raubenheimer, D., Cogger, V., Macia, L., Solon-Biet, S., Le Couteur, D., George, J. (2018). The nutritional geometry of liver disease including non-alcoholic fatty liver disease (NAFLD). Journal of Hepatology, 68(2), 316-325. [More Information]
Gokarn, R., Solon-Biet, S., Youngson, N., Wahl, D., Cogger, V., McMahon, A., Cooney, G., Ballard, J., Raubenheimer, D., Morris, M., Simpson, S., Le Couteur, D. (2018). The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(4), 446-449. [More Information]
Hsu, B., Merom, D., Blyth, F., Naganathan, V., Hirani, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2018). Total Physical Activity, Exercise Intensity, and Walking Speed as Predictors of All-Cause and Cause-Specific Mortality Over 7 Years in Older Men: The Concord Health and Aging in Men Project. Journal of the American Medical Directors Association (JAMDA), 19(3), 216-222. [More Information]
Kane, A., Huizer-Pajkos, A., Mach, J., Mitchell, S., de Cabo, R., Le Couteur, D., Howlett, S., Hilmer, S. (2017). A Comparison of Two Mouse Frailty Assessment Tools. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 904-910. [More Information]
Sierro, F., Evrard, M., Rizzetto, S., Melino, M., Mitchell, A., Florido, M., Beattie, L., Walters, S., Tay, S., Lu, B., Roediger, B., Wong, Y., Warren, A., Ritchie, W., McGuffog, C., Weninger, W., Le Couteur, D., Britton, W., Saunders, B., McCaughan, G., Bowen, D., Bertolino, P., et al (2017). A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment. Immunity, 47(2), 374-388. [More Information]
Anderson, R., Le Couteur, D., de Cabo, R. (2017). Caloric Restriction Research: New Perspectives on the Biology of Aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(1), 1-3. [More Information]
Wahl, D., Coogan, S., Solon-Biet, S., de Cabo, R., Haran, J., Raubenheimer, D., Cogger, V., Mattson, M., Simpson, S., Le Couteur, D. (2017). Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia. Clinical Interventions in Aging, 12, 1419-1428. [More Information]
Le Couteur, D., Wahl, D., Naismith, S. (2017). Comorbidity and vascular cognitive impairment- no dementia (VCI-ND). Age and Ageing, 46(5), 705-707. [More Information]
Ribeiro, R., Hirani, V., Senior, A., Gosby, A., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Kendig, H., Seibel, M., Simpson, S., Stanaway, F., Allman-Farinelli, M., Le Couteur, D. (2017). Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP). British Journal of Nutrition, 118, 130-143. [More Information]
Holmes, A., Chew, Y., Colakoglu, F., Cliff, J., Klaassens, E., Read, M., Solon-Biet, S., McMahon, A., Cogger, V., Ruohonen, K., Raubenheimer, D., Le Couteur, D., Simpson, S. (2017). Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints. Cell Metabolism, 25(1), 140-151. [More Information]
Simpson, S., Le Couteur, D., Raubenheimer, D., Solon-Biet, S., Cooney, G., Cogger, V., Fontana, L. (2017). Dietary protein, aging and nutritional geometry. Ageing Research Reviews, 39, 78-86. [More Information]
Gaddam, R., Fraser, R., Badiei, A., Chambers, S., Cogger, V., Le Couteur, D., Bhatia, M. (2017). Differential effects of kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. [More Information]
Jamsen, K., Gnjidic, D., Hilmer, S., Ilomaki, J., Le Couteur, D., Blyth, F., Handelsman, D., Naganathan, V., Waite, L., Cumming, R., et al (2017). Drug Burden Index and change in cognition over time in community-dwelling older men: the CHAMP study. Annals of Medicine, 49(2), 157-164. [More Information]
Alfaras, I., Mitchell, S., Mora, H., Lugo, D., Warren, A., Navas-Enamorado, I., Hoffmann, V., Hine, C., Mitchell, J., Le Couteur, D., Cogger, V., et al (2017). Health benefits of late-onset metformin treatment every other week in mice. NPJ Aging and Mechanisms of Disease, 3, 1-13. [More Information]
Shu, C., Cumming, R., Kendig, H., Blyth, F., Waite, L., Le Couteur, D., Handelsman, D., Naganathan, V. (2017). Health status, health behaviours and anxiety symptoms of older male caregivers: Findings from the Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 36(2), 151-157. [More Information]
Cogger, V., Mohamad, M., Le Couteur, D. (2017). It's the holes that matter. Aging, 9(11), 2237-2238. [More Information]
Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2017). Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community-dwelling older men: The Concord Health and Ageing in men project. Age and Ageing, 46(3), 413-420. [More Information]
Noguchi, N., Chan, L., Cumming, R., Blyth, F., Handelsman, D., Waite, L., Le Couteur, D., Naganathan, V. (2017). Natural history of non-neurogenic overactive bladder and urinary incontinence over 5 years in community-dwelling older men: The concord health and aging in men project. Neurourology and Urodynamics, 36(2), 443-448. [More Information]
Held, F., Le Couteur, D., Blyth, F., Hirani, V., Naganathan, V., Waite, L., Seibel, M., Handelsman, D., Cumming, R., Allore, H., Gnjidic, D. (2017). Polypharmacy in older adults: Association Rule and Frequent-Set Analysis to evaluate concomitant medication use. Pharmacological Research, 116, 39-44. [More Information]
Wright, F., Law, G., Chu, S., Cullen, J., Le Couteur, D. (2017). Residential age care and domiciliary oral health services: Reach-OHT—The development of a metropolitan oral health programme in Sydney, Australia. Gerodontology, 34(4), 420-426. [More Information]
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Hirani, V. (2017). Sarcopenic Obesity and Its Temporal Associations With Changes in Bone Mineral Density, Incident Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project. Journal of Bone and Mineral Research, 32(3), 575-583. [More Information]
Hsu, B., Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2017). Sexual Function and Mortality in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(4), 520-527. [More Information]
Razi, S., Cogger, V., Kennerson, M., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Hirani, V., Naganathan, V., Waite, L., Cumming, R., Le Couteur, D., et al (2017). SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 870-876. [More Information]
Le Couteur, D., Anderson, R., Newman, A., de Cabo, R. (2017). Stem Cell Transplantation for Frailty. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(11), 1503-1504. [More Information]
Painter, V., Le Couteur, D., Waite, L. (2017). Texture-modified food and fluids in dementia and residential aged care facilities. Clinical Interventions in Aging, 12, 1193-1203. [More Information]
Simpson, S., Le Couteur, D., James, D., George, J., Gunton, J., Solon-Biet, S., Raubenheimer, D. (2017). The Geometric Framework for Nutrition as a tool in precision medicine. Nutrition and Healthy Aging, 4(3), 217-226. [More Information]
Kane, A., Mitchell, S., Mach, J., Huizer-Pajkos, A., McKenzie, C., Jones, B., Cogger, V., Le Couteur, D., de Cabo, R., Hilmer, S. (2016). Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. Experimental Gerontology, 73, 95-106. [More Information]
Huizer-Pajkos, A., Kane, A., Howlett, S., Mach, J., Mitchell, S., De Cabo, R., Le Couteur, D., Hilmer, S. (2016). Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(5), 571-577. [More Information]
Held, F., Blyth, F., Gnjidic, D., Hirani, V., Naganathan, V., Waite, L., Seibel, M., Rollo, J., Handelsman, D., Cumming, R., Le Couteur, D. (2016). Association Rules Analysis of Comorbidity and Multimorbidity: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(5), 625-631. [More Information]
Gaddam, R., Fraser, R., Badiei, A., Chambers, S., Cogger, V., Le Couteur, D., Ishii, I., Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PloS One, 11(8), 1-21. [More Information]
Solon-Biet, S., Cogger, V., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A., Warren, A., Durrant-Whyte, J., Walters, K., Krycer, J., Ponton, F., Gokarn, R., Wali, J., Conigrave, A., James, D., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2016). Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework. Cell Metabolism, 24(4), 555-565. [More Information]
Cogger, V., Mohamad, M., Solon-Biet, S., Senior, A., Warren, A., O'Reilly, J., Tung, B., Svistounov, D., McMahon, A., Fraser, R., Raubenheimer, D., Holmes, A., Simpson, S., Le Couteur, D. (2016). Dietary Macronutrients and the Aging Liver Sinusoidal Endothelial Cell. American Journal of Physiology - Heart and Circulatory Physiology, 310(9), H1064-H1070. [More Information]
Jamsen, K., Bell, J., Hilmer, S., Kirkpatrick, C., Ilomaki, J., Le Couteur, D., Blyth, F., Handelsman, D., Waite, L., Naganathan, V., Cumming, R., Gnjidic, D. (2016). Effects of Changes in Number of Medications and Drug Burden Index Exposure on Transitions between Frailty States and Death: The Concord Health and Ageing in Men Project Cohort Study. Journal of the American Geriatrics Society, 64(1), 89-95. [More Information]
Noguchi, N., Chan, L., Cumming, R., Blyth, F., Handelsman, D., Seibel, M., Waite, L., Le Couteur, D., Naganathan, V. (2016). Lower Urinary Tract Symptoms and Incident Falls in Community Dwelling Older Men: The Concord Health and Ageing in Men Project. The Journal of Urology, 196(6), 1694-1699. [More Information]
Kane, A., Huizer-Pajkos, A., Mach, J., McKenzie, C., Mitchell, S., De Cabo, R., Jones, B., Cogger, V., Le Couteur, D., Hilmer, S. (2016). N-Acetyl Cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. Fundamental and Clinical Pharmacology, 30(3), 263-275. [More Information]
Le Couteur, D., Solon-Biet, S., Wahl, D., Cogger, V., Willcox, B., Willcox, D., Raubenheimer, D., Simpson, S. (2016). New Horizons: Dietary protein, ageing and the Okinawan ratio. Age and Ageing, 45(4), 443-447. [More Information]
Raubenheimer, D., Simpson, S., Le Couteur, D., Solon-Biet, S., Coogan, S. (2016). Nutritional ecology and the evolution of aging. Experimental Gerontology, 86, 50-61. [More Information]
Wahl, D., Cogger, V., Solon-Biet, S., Ribeiro, R., Gokarn, R., Pulpitel, T., de Cabo, R., Mattson, M., Raubenheimer, D., Simpson, S., Le Couteur, D. (2016). Nutritional strategies to optimise cognitive function in the aging brain. Ageing Research Reviews, 31, 80-92. [More Information]
Le Couteur, D., McLachlan, A., Hilmer, S. (2016). Polypharmacy in older people: When should you deprescribe? Medicine Today, 7(6), 16-24.
Noguchi, N., Blyth, F., Waite, L., Naganathan, V., Cumming, R., Handelsman, D., Seibel, M., Le Couteur, D. (2016). Prevalence of the geriatric syndromes and frailty in older men living in the community: The Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 35(4), 255-261. [More Information]
Hsu, B., Seibel, M., Cumming, R., Blyth, F., Naganathan, V., Bleicher, K., Le Couteur, D., Waite, L., Handelsman, D. (2016). Progressive Temporal Change in Serum SHBG, But Not in Serum Testosterone or Estradiol, Is Associated With Bone Loss and Incident Fractures in Older Men: The Concord Health and Ageing in Men Project. Journal of Bone and Mineral Research, 31(12), 2115-2122. [More Information]
Le Couteur, D., Hunter, S., Brayne, C. (2016). Solanezumab and the amyloid hypothesis for Alzheimer's disease. BMJ, 355, 1-2. [More Information]
Hilmer, S., Le Couteur, D. (2016). Standardized, Multidisciplinary Approaches for the Study of Aging Biology and for Translation of Aging Interventions. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(4), 425-426. [More Information]
Hsu, B., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Hirani, V., Waite, L., Seibel, M., Handelsman, D. (2016). Temporal Changes in Androgens and Estrogens are associated with All-Cause and Cause-Specific Mortality in Older Men. Journal of Clinical Endocrinology and Metabolism, 10(5), 2201-2210. [More Information]
Hsu, B., Cumming, R., Hirani, V., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2016). Temporal Trend in Androgen Status and Androgen-Sensitive Outcomes in Older Men. Journal of Clinical Endocrinology and Metabolism, 101(4), 1836-1846. [More Information]
Mach, J., Huizer-Pajkos, A., Mitchell, S., McKenzie, C., Phillips, L., Kane, A., Jones, B., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2016). The effect of aging on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundamental and Clinical Pharmacology, 30(1), 23-34. [More Information]
Hew, J., Solon-Biet, S., McMahon, A., Ruohonen, K., Raubenheimer, D., Ballard, J., Le Couteur, D., Nicholls, C., Li, Z., Maitz, P., Wang, Y., Simpson, S. (2016). The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice. PloS One, 11(11), 1-15. [More Information]
Le Couteur, D., Solon-Biet, S., Cogger, V., Mitchell, S., Senior, A., de Cabo, R., Raubenheimer, D., Simpson, S. (2016). The impact of low-protein high-carbohydrate diets on aging and lifespan. Cellular and Molecular Life Sciences, 73(6), 1237-1252. [More Information]
Mohamad, M., Mitchell, S., Wu, L., White, M., Cordwell, S., Mach, J., Solon-Biet, S., Boyer, D., Nines, D., Das, A., Warren, A., Hilmer, S., Simpson, S., Le Couteur, D., Cogger, V., et al (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15(4), 706-715. [More Information]
Aumailley, L., Warren, A., Garand, C., Dubois, M., Paquet, E., Le Couteur, D., Marette, A., Cogger, V., Lebel, M. (2016). Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice. Aging, 8(3), 458-483. [More Information]
Cogger, V., O'Reilly, J., Warren, A., Le Couteur, D. (2015). A standardized method for the analysis of liver sinusoidal endothelial cells and their fenestrations by scanning electron microscopy. Journal of Visualized Experiments, 30(98), 1-9. [More Information]
Hirani, V., Blyth, F., Naganathan, V., Cumming, R., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2015). Active vitamin D (1,25 dihydroxyvitamin D) is associated with chronic pain in older Australian men: the Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70(3), 387-395. [More Information]
Ribeiro, R., Cumming, R., Blyth, F., Naganathan, V., Allman-Farinelli, M., Le Couteur, D., Simpson, S., Kendig, H., Hirani, V. (2015). Adequacy of nutritional intake among older men living in Sydney, Australia: Findings from the Concord Health and Ageing in Men Project (CHAMP). British Journal of Nutrition, 114(5), 812-821. [More Information]
Scott, I., Le Couteur, D. (2015). Author reply. Internal Medicine Journal, 45(8), 885-886. [More Information]
Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D., Kelly, P., Handelsman, D., Waite, L., Cumming, R. (2015). Cross-Sectional and Longitudinal Associations Between Anemia and Frailty in Older Australian Men: The Concord Health and Aging in Men Project. Journal of the American Medical Directors Association (JAMDA), 16(7), 614-620. [More Information]
Hirani, V., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Waite, L., Handelsman, D., Seibel, M. (2015). Cross-sectional and longitudinal associations between the active vitamin D metabolite (1,25 dihydroxyvitamin D) and haemoglobin levels in older Australian men: the Concord Health and Ageing in Men Project. Age, 37(1), 1-13. [More Information]
Solon-Biet, S., Mitchell, S., Coogan, S., Cogger, V., Gokarn, R., McMahon, A., Raubenheimer, D., De Cabo, R., Simpson, S., Le Couteur, D. (2015). Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice. Cell Reports, 11(10), 1529-1534. [More Information]
Liang, X., Grice, J., Zhu, Y., Liu, D., Sanchez, W., Li, Z., Crawford, D., Le Couteur, D., Cogger, V., Liu, X., et al (2015). Intravital Multiphoton Imaging of the Selective Uptake of Water-Dispersible Quantum Dots into Sinusoidal Liver Cells. Small, 11(14), 1711-1720. [More Information]
Gnjidic, D., Bennett, A., Le Couteur, D., Blyth, F., Cumming, R., Waite, L., Handelsman, D., Naganathan, V., Matthews, S., Hilmer, S. (2015). Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study. International Journal of Cardiology, 192, 49-55. [More Information]
Hsu, B., Cumming, R., Waite, L., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Handelsman, D. (2015). Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 100(6), 2223-2230. [More Information]
Solon-Biet, S., Walters, K., Simanainen, U., McMahon, A., Ruohonen, K., Ballard, J., Raubenheimer, D., Handelsman, D., Le Couteur, D., Simpson, S. (2015). Macronutrient balance, reproductive function, and lifespan in aging mice. Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3481-3486. [More Information]
Solon-Biet, S., Mitchell, S., De Cabo, R., Raubenheimer, D., Le Couteur, D., Simpson, S. (2015). Macronutrients and caloric intake in health and longevity. Journal of Endocrinology, 226(1), R17-R28. [More Information]
Scott, I., Le Couteur, D. (2015). Physicians need to take the lead in deprescribing. Internal Medicine Journal, 45(3), 352-356. [More Information]
Simpson, S., Le Couteur, D., Raubenheimer, D. (2015). Putting the Balance Back in Diet. Cell, 161(1), 18-23. [More Information]
Scott, I., Hilmer, S., Reeve, E., Potter, K., Le Couteur, D., Rigby, D., Gnjidic, D., Del Mar, C., Roughead, E., Page, A., Jansen, J., et al (2015). Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Internal Medicine, 175(5), 827-834. [More Information]
Hsu, B., Cumming, R., Seibel, M., Naganathan, V., Blyth, F., Bleicher, K., Dave, A., Le Couteur, D., Waite, L., Handelsman, D. (2015). Reproductive Hormones and Longitudinal Change in Bone Mineral Density and Incident Fracture Risk in Older Men: The Concord Health and Aging in Men Project. Journal of Bone and Mineral Research, 30(9), 1701-1708. [More Information]
Hirani, V., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2015). Sarcopenia Is Associated With Incident Disability, Institutionalization, and Mortality in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. Journal of the American Medical Directors Association (JAMDA), 16(7), 607-613. [More Information]
Sierro, F., Tay, S., Warren, A., Le Couteur, D., McCaughan, G., Bowen, D., Bertolino, P. (2015). Suicidal Emperipolesis: A process leading to cell-in-cell structures, T cell clearance and immune homeostasis. Current Molecular Medicine, 15(9), 819-827. [More Information]
Mach, J., Huizer-Pajkos, A., Kane, A., Jones, B., McKenzie, C., Mitchell, S., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2015). The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. Experimental Gerontology, 67, 54-61. [More Information]
Le Couteur, D., Tay, S., Solon-Biet, S., Bertolino, P., McMahon, A., Cogger, V., Colakoglu, F., Warren, A., Holmes, A., Pichaud, N., Raubenheimer, D., Simpson, S., et al (2015). The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 70(12), 1499-1507. [More Information]
Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2015). The Longitudinal Relationship of Sexual Function and Androgen Status in Older Men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 100(4), 1350-1358. [More Information]
Scheibye-Knudsen, M., Mitchell, S., Fang, E., Iyama, T., Ward, T., Wang, J., Dunn, C., Singh, N., Veith, S., Hasan-Olive, M., Cogger, V., Warren, A., Le Couteur, D., et al (2014). A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. Cell Metabolism, 20(5), 840-855. [More Information]
Fransen, M., Su, S., Harmer, A., Blyth, F., Naganathan, V., Sambrook, P., Le Couteur, D., Cumming, R. (2014). A longitudinal study of knee pain in older men: Concord Health and Ageing in Men Project. Age and Ageing, 43(2), 206-212. [More Information]
Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
Ilomaki, J., Gnjidic, D., Le Couteur, D., Bell, J., Blyth, F., Handelsman, D., Cumming, R., Seibel, M., Waite, L., Naganathan, V., Hilmer, S. (2014). Alcohol consumption and tobacco smoking among community-dwelling older Australian men: the Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 33(3), 185-192. [More Information]
Le Couteur, D., Simpson, S., De Cabo, R. (2014). Are glycans the holy grail for biomarkers of aging? (Comment on: Glycans Are a Novel Biomarker of Chronological and Biological Age by Kristic et al.). Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(7), 777-778. [More Information]
Kouladjian-O'Donnell, L., Hilmer, S., Chen, T., Le Couteur, D., Gnjidic, D. (2014). Assessing the harms of polypharmacy requires careful interpretation and consistent definitions. British Journal of Clinical Pharmacology, 78(3), 670-671. [More Information]
Hsu, B., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Associations between circulating reproductive hormones and SHBG and prevalent and incident metabolic syndrome in community-dwelling older men: the Concord Health and Ageing in Men Project. The Journal of Clinical Endocrinology and Metabolism, 99(12), E2686-E2691. [More Information]
Hirani, V., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014). Associations Between Serum 25-Hydroxyvitamin D Concentrations and Multiple Health Conditions, Physical Performance Measures, Disability, and All-Cause Mortality: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(3), 417-425. [More Information]
Gnjidic, D., Le Couteur, D., Hilmer, S. (2014). Discontinuing drug treatments. BMJ, 349, g7013. [More Information]
Cogger, V., Svistounov, D., Warren, A., Zykova, S., Melvin, R., Solon-Biet, S., O'Reilly, J., McMahon, A., Ballard, J., De Cabo, R., Le Couteur, D., et al (2014). Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(9), 1076-1086. [More Information]
Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Longitudinal and Cross-Sectional Relationships of Circulating Reproductive Hormone Levels to Self-Rated Health and Health-Related Quality of Life in Community-Dwelling Older Men. The Journal of Clinical Endocrinology and Metabolism, 99(5), 1638-1647. [More Information]
Hsu, B., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Longitudinal relationships of circulating reproductive hormone with functional disability, muscle mass and strength in community-dwelling older men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 99(9), 3310-3318. [More Information]
Hirani, V., Cumming, R., Le Couteur, D., Naganathan, V., Blyth, F., Handelsman, D., Waite, L., Seibel, M. (2014). Low Levels of 25-Hydroxy Vitamin D and Active 1,25-Dihydroxyvitamin D Independently Associated with Type 2 Diabetes Mellitus in Older Australian Men: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(9), 1741-1747. [More Information]
Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D., Gnjidic, D., Stanaway, F., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2014). Multiple, but not traditional risk factors predict mortality in older people: the concord health and ageing in men project. Age, 36(6), 1-15. [More Information]
Gnjidic, D., Blyth, F., Le Couteur, D., Cumming, R., McLachlan, A., Handelsman, D., Seibel, M., Waite, L., Naganathan, V. (2014). Nonsteroidal anti-inflammatory drugs (NSAIDs) in older people: Prescribing patterns according to pain prevalence and adherence to clinical guidelines. Pain, 155(9), 1814-1820. [More Information]
Fairhall, N., Sherrington, C., Cameron, I., Blyth, F., Naganathan, V., Clemson, L., Le Couteur, D., Handelsman, D., Waite, L., Cumming, R. (2014). Predicting participation restriction in community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 43(1), 31-37. [More Information]
Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Bell, J. (2014). Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology, 28(1), 10-19. [More Information]
Le Couteur, D., Brayne, C. (2014). Should Family Physicians Routinely Screen Patients for Cognitive Impairment? No: Screening Has Been Inappropriately Urged Despite Absence of Evidence. American Family Physician, 89(11), 864-865.
Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
Le Couteur, D., Wilder, S., De Cabo, R., Simpson, S. (2014). The Evolution of Research on Ageing and Nutrition. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(1), 1-2. [More Information]
Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]
Bleicher, K., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014). U-Shaped Association Between Serum 25-Hydroxyvitamin D and Fracture Risk in Older Men: Results from the Prospective Population Based CHAMP Study. Journal of Bone and Mineral Research, 29(9), 2024-2031. [More Information]
Cogger, V., Roessner, U., Warren, A., Fraser, R., Le Couteur, D. (2013). A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations. Computational and Structural Biotechnology Journal, 8(11), 1-9. [More Information]
Hirani, V., Naganathan, V., Cumming, R., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013). Associations Between Frailty and Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Concentrations in Older Australian Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 68(9), 1112-1121. [More Information]
McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013). Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica, 50(4), 645-649. [More Information]
Wilder, S., Le Couteur, D., Simpson, S. (2013). Diet mediates the relationship between longevity and reproduction in mammals. Age, 35(3), 921-927. [More Information]
Gnjidic, D., Le Couteur, D., Hilmer, S. (2013). Discontinuation of statins in routine care settings. Annals of Internal Medicine, 159(1), 73-74. [More Information]
Huang, X., Hancock, D., Gosby, A., McMahon, A., Solon-Biet, S., Le Couteur, D., Conigrave, A., Raubenheimer, D., Simpson, S. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage and heat production in mice. Obesity, 21(1), 85-92. [More Information]
Gnjidic, D., Le Couteur, D., Pearson, S., McLachlan, A., Viney, R., Hilmer, S., Blyth, F., Joshy, G., Banks, E. (2013). High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health, 13, 1-9. [More Information]
Gnjidic, D., Hilmer, S., Le Couteur, D. (2013). Optimal cutoff of polypharmacy and outcomes - reply. Journal of Clinical Epidemiology, 66(4), 465-466. [More Information]
Le Couteur, D., Doust, J., Creasey, H., Brayne, C. (2013). Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis. BMJ, 347(7925), 1-6. [More Information]
Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2013). Predictors of the rate of BMD loss in older men: findings from the CHAMP study. Osteoporosis International, 24(7), 1951-1963. [More Information]
Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., et al (2013). Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review, 32(2), 218-222. [More Information]
Horan, M., Rumbley, J., Melvin, R., Le Couteur, D., Ballard, J. (2013). Quaternary protein modeling to predict the function of DNA variation found in human mitochondrial cytochrome c oxidase. Journal of Human Genetics, 58(3), 127-134. [More Information]
Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013). Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open, 3(3), 1-10. [More Information]
Hirani, V., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013). Vitamin D Status Among Older Community Dwelling Men Living In A Sunny Country And Associations With Lifestyle Factors: The Concord Health And Ageing In Men Project, Sydney, Australia. Journal of Nutrition, Health and Aging, 17(7), 587-593. [More Information]
Le Couteur, D., Robinson, M., Leverton, A., Creasey, H., Waite, L., Atkins, K., McLachlan, A. (2012). Adherence, persistence and continuation with cholinesterase inhibitors in Alzheimer's disease. Australasian Journal on Ageing, 31(3), 164-169. [More Information]
Le Couteur, D., McLachlan, A., Quinn, R., Simpson, S., De Cabo, R. (2012). Aging biology and novel targets for drug discovery. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 67A(2), 168-174. [More Information]
Le Couteur, D., McLachlan, A., De Cabo, R. (2012). Aging, Drugs, and Drug Metabolism. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 137-139. [More Information]
Baur, J., Ungvari, Z., Minor, R., Le Couteur, D., De Cabo, R. (2012). Are sirtuins viable targets for improving healthspan and lifespan? Nature Reviews. Drug Discovery, 11(6), 443-461. [More Information]
Gnjidic, D., Le Couteur, D., Kouladjian, L., Hilmer, S. (2012). Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clinics in Geriatric Medicine, 28(2), 237-253. [More Information]
Le Couteur, D., Handelsman, D. (2012). DNA damage, NF-κB and accelerated aging. Asian Journal of Andrology, 14(6), 811-812. [More Information]
Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2012). Drug Burden Index and Beers Criteria: Impact on Functional Outcomes in Older People Living in Self-Care Retirement Villages. The Journal of Clinical Pharmacology, 52(2), 258-265. [More Information]
Gnjidic, D., Le Couteur, D., Naganathan, V., Cumming, R., Creasey, H., Waite, L., Sharma, A., Blyth, F., Hilmer, S. (2012). Effects of drug burden index on cognitive function in older men. Journal of Clinical Psychopharmacology, 32(2), 273-277. [More Information]
Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology & Therapeutics, 91(3), 521-528. [More Information]
Gnjidic, D., Hilmer, S., Le Couteur, D. (2012). High-risk prescribing in older people: More harm than good? Aging Health, 8(4), 325-327. [More Information]
Bell, S., Le Couteur, D., McLachlan, A., Chen, T., Moles, R., Basger, B., Hilmer, S. (2012). Improving medicine selection for older people: Do we need an Australian classification for inappropriate medicines use? Australian Family Physician, 41(1/2), 9-10. [More Information]
Gnjidic, D., Stanaway, F., Cumming, R., Waite, L., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D. (2012). Mild Cognitive Impairment Predicts Institutionalization among Older Men: A Population-Based Cohort Study. PloS One, 7(9), 1-8. [More Information]
Gnjidic, D., Le Couteur, D., Hilmer, S. (2012). Off-Label Use of Medicines: Time for Action. Clinical Pharmacology & Therapeutics, 92(2), 157-157. [More Information]
Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012). Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989-995. [More Information]
Litchfield, M., Cumming, R., Smith, D., Naganathan, V., Le Couteur, D., Waite, L., Blyth, F., Handelsman, D. (2012). Prostate-specific antigen levels in men aged 70 years and over: Findings from the CHAMP study. Medical Journal of Australia, 196(6), 395-398. [More Information]
Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
Svistounov, D., Warren, A., McNerney, G., Owen, D., Zencak, D., Zykova, S., Crane, H., Huser, T., Quinn, R., Smedsrod, B., Le Couteur, D., Cogger, V. (2012). The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells. PloS One, 7(9), 1-9. [More Information]
Sorensen, K., McCourt, P., Berg, T., Crossley, C., Le Couteur, D., Wake, K., Smedsrod, B. (2012). The scavenger endothelial cell: a new player in homeostasis and immunity. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 303(12), R1217-R1230. [More Information]
Hilmer, S., Gnjidic, D., Le Couteur, D. (2012). Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Australian Family Physician, 41(12), 924-928. [More Information]
Le Couteur, D., Simpson, S. (2011). Adaptive Senectitude: The Prolongevity Effects of Aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 66A(2), 179-182. [More Information]
Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
Stanaway, F., Blyth, F., Cumming, R., Naganathan, V., Handelsman, D., Waite, L., Sambrook, P., Creasey, H., Seibel, M., Le Couteur, D. (2011). Back pain in older male Italian-born immigrants in Australia: The importance of socioeconomic factors. European Journal of Pain, 15(1), 70-76. [More Information]
Travison, T., Nguyen, A., Naganathan, V., Stanaway, F., Blyth, F., Cumming, R., Le Couteur, D., Sambrook, P., Handelsman, D. (2011). Changes in Reproductive Hormone Concentrations Predict the Prevalence and Progression of the Frailty Syndrome in Older Men: The Concord Health and Ageing in Men Project. The Journal of Clinical Endocrinology and Metabolism, 96(8), 2464-2474. [More Information]
McLachlan, A., Bath, S., Naganathan, V., Hilmer, S., Le Couteur, D., Gibson, S., Blyth, F. (2011). Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. British Journal of Clinical Pharmacology, 71(3), 351-364. [More Information]
Le Couteur, D., Banks, E., Gnjidic, D., McLachlan, A. (2011). Deprescribing. Australian Prescriber, 34(6), 182-185. [More Information]
Le Couteur, D., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Kennerson, M., Naganathan, V., Cumming, R., De Cabo, R. (2011). Determinants of Serum-Induced SIRT1 Expression in Older Men: The CHAMP Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(1), 3-8. [More Information]
Stanaway, F., Cumming, R., Naganathan, V., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M., Sambrook, P. (2011). Ethnicity and falls in older men: low rate of falls in Italian-born men in Australia. Age and Ageing, 40, 595-601. [More Information]
Le Couteur, D., Cogger, V., Dobbs, B., Fraser, R. (2011). Fenestrations and lipoproteins. Cardiovascular Pathology, 20(3), 191-193. [More Information]
Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16735-16740. [More Information]
Stanaway, F., Gnjidic, D., Blyth, F., Le Couteur, D., Naganathan, V., Waite, L., Seibel, M., Handelsman, D., Sambrook, P., Cumming, R. (2011). How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ: British Medical Journal, 343, d7679-1-d7679-4. [More Information]
Blyth, F., Cumming, R., Nicholas, M., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2011). Intrusive Pain and Worry about Health in Older Men: The CHAMP Study. Pain, 152(2), 447-452. [More Information]
Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2011). Reducing drugs in older adults is more. Archives of Internal Medicine, 171(9), 868-869. [More Information]
LabbÃ©, A., Garand, C., Cogger, V., Paquet, E., Desbiens, M., Le Couteur, D., Lebel, M. (2011). Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(312492), 264-278. [More Information]
Nabipour, I., Sambrook, P., Blyth, F., Janu, M., Waite, L., Naganathan, V., Handelsman, D., Le Couteur, D., Cumming, R., Seibel, M. (2011). Serum Uric Acid Is Associated With Bone Health in Older Men: A Cross-Sectional Population-Based Study. Journal of Bone and Mineral Research, 26(5), 955-964. [More Information]
Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2011). Socioeconomic status and bone health in community-dwelling older men: The CHAMP Study. Osteoporosis International, 22(5), 1343-1353. [More Information]
Everitt, A., Le Couteur, D., Kendig, H. (2011). The Changing Face of Ageing Research and Practice in Australia over the last 50 years. Australasian Journal on Ageing, 30(4), 173-174. [More Information]
Warren, A., Cogger, V., Fraser, R., DeLeve, L., McCuskey, R., Le Couteur, D. (2011). The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research, 2011, 1-7. [More Information]
Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]
Bleicher, K., Cumming, R., Naganathan, V., Travison, T., Sambrook, P., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M. (2011). The role of fat and lean mass in bone loss in older men: Findings from the CHAMP study. Bone, 49(6), 1299-1305. [More Information]
Le Couteur, D., Sinclair, D. (2010). A Blueprint for Developing Therapeutic Approaches That Increase Healthspan and Delay Death. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(7), 693-4. [More Information]
Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2010). A Pilot Randomized Clinical Trial Utilizing the Drug Burden Index to Reduce Exposure to Anticholinergic and Sedative Medications in Older People. The Annals of Pharmacotherapy, 44(11), 1725-1732. [More Information]
Le Couteur, D., Lakatta, E. (2010). A Vascular Theory of Aging. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(10), 1025-7. [More Information]
Simon-Santamaria, J., Malovic, I., Warren, A., Oteiza, A., Le Couteur, D., Smedsrod, B., McCourt, P., Sorensen, K. (2010). Age-Related Changes in Scavenger Receptor-Mediated Endocytosis in Rat Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(9), 951-960. [More Information]
Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
Le Couteur, D., Ford, G., McLachlan, A. (2010). Evidence, Ethics and Medication Management in Older People. Journal of Pharmacy Practice and Research, 40(2), 148-152.
Rochat, S., Cumming, R., Blyth, F., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2010). Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 39(2), 228-233. [More Information]
Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2010). Lifestyle factors, medications, and disease influence bone mineral density in older men: findings from the CHAMP study. Osteoporosis International, 22(9), 1-17. [More Information]
Warren, A., Cogger, V., Arias, I., McCuskey, R., Le Couteur, D. (2010). Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice. Microcirculation, 17(1), 32-38. [More Information]
Hairi, N., Cumming, R., Naganathan, V., Handelsman, D., Le Couteur, D., Creasey, H., Waite, L., Seibel, M., Sambrook, P. (2010). Loss of Muscle Strength, Mass (Sarcopenia), and Quality (Specific Force) and Its Relationship with Functional Limitation and Physical Disability: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 58(11), 2055-2062. [More Information]
Pallardo, F., Lloret, A., Lebel, M., dâ€™Ischia, M., Cogger, V., Le Couteur, D., Gadaleta, M., Castello, G., Pagano, G. (2010). Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. Biogerontology, 11(4), 401-419. [More Information]
Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2010). Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. International Journal of Infectious Diseases, 14(10), e857-e867. [More Information]
Bleicher, K., Naganathan, V., Cumming, R., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Creasey, H. (2010). Prevalence and treatment of osteoporosis in older Australian men: findings from the CHAMP study. Medical Journal of Australia, 193(7), 387-391. [More Information]
Le Couteur, D. (2010). Red yeast rice for dyslipidemia in statin-intolerant patients. Annals of Internal Medicine, 152(2), 134-135. [More Information]
Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2010). Socioeconomic status and bone health in community-dwelling older men: the CHAMP Study. Osteoporosis International, 22(5), 1343-1353. [More Information]
Le Couteur, D., Blyth, F., Creasey, H., Handelsman, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L., Cumming, R. (2010). The Association of Alanine Transaminase With Aging, Frailty, and Mortality. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(7), 712-717. [More Information]
Sabaretnam, T., Kritharides, L., O'Reilly, J., Le Couteur, D. (2010). The effect of aging on the response of isolated hepatocytes to hydrogen peroxide and tert-butyl hydroperoxide. Toxicology in Vitro, 24(1), 123-128. [More Information]
O'Reilly, J., Cogger, V., Fraser, R., Le Couteur, D. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. [More Information]
Sabaretnam, T., O'Reilly, J., Kritharides, L., Le Couteur, D. (2010). The effect of old age on apolipoprotein E and its receptors in rat liver. Age, 32(1), 69-77. [More Information]
Cogger, V., McNerney, G., Nyunt, T., DeLeve, L., McCourt, P., Smedsrod, B., Le Couteur, D., Huser, T. (2010). Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. Journal of Structural Biology, 171(3), 382-388. [More Information]
Kwong, P., Cumming, R., Chan, L., Seibel, M., Naganathan, V., Creasey, H., Le Couteur, D., Waite, L., Sambrook, P., Handelsman, D. (2010). Urinary incontinence and quality of life among older community-dwelling Australian men: the CHAMP study. Age and Ageing, 39(3), 349-354. [More Information]
Massip, L., Garand, C., Paquet, E., Cogger, V., O'Reilly, J., Tworek, L., Hatherall, A., Taylor, C., Thorin, E., Zahradka, P., Le Couteur, D., et al (2010). Vitamin C restores healthy aging in a mouse model for Werner syndrome. The FASEB Journal, 24(1), 158-172. [More Information]
Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009). Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology, 68(1), 97-105. [More Information]
Sabaretnam, T., Harris, M., Kockx, M., Witting, P., Le Couteur, D., Kritharides, L. (2009). Effects of hydrogen peroxide and apolipoprotein e isoforms on apolipoprotein e trafficking in HepG2 cells. Clinical and Experimental Pharmacology and Physiology, 36(12), e96-e102. [More Information]
Smedsrd, B., Le Couteur, D., Ikejima, K., Kawada, N., Naito, M., Knolle, P., Nagy, L., Senoo, H., Vidal-Vanaclocha, F., Yamaguchi, N., et al (2009). Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium. Liver International, 29(4), 490-501. [More Information]
O'Reilly, J., Cogger, V., Le Couteur, D. (2009). Old age is associated with ultrastructural changes in isolated rat liver sinusoidal endothelial cells. Journal of Electron Microscopy, 59(1), 65-69. [More Information]
Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2009). Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. Pathology, 41(7), 615-621. [More Information]
Le Couteur, D., Everitt, A., Lebel, M. (2009). The aging liver. Geriatrics and Ageing, 12(6), 319-322.
McLachlan, A., Hilmer, S., Le Couteur, D. (2009). Variability in response to medicines in older people: Phenotypic and genotypic factors. Clinical Pharmacology & Therapeutics, 85(4), 431-433. [More Information]
Cumming, R., Handelsman, D., Seibel, M., Creasey, H., Sambrook, P., Waite, L., Naganathan, V., Le Couteur, D., Litchfield, M. (2008). Cohort profile: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology, 38(2), 374-378. [More Information]
Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
Iyer, S., Naganathan, V., McLachlan, A., Le Couteur, D. (2008). Medication Withdrawal Trials in People Aged 65 Years and Older: A Systematic Review. Drugs and Aging, 25(12), 1021-1031. [More Information]
Le Couteur, D., Warren, A., Cogger, V., Smedsrod, B., Sorensen, K., De Cabo, R., Fraser, R., McCuskey, R. (2008). Old age and the hepatic sinusoid. The Anatomical Record, 291(6), 672-683. [More Information]
Blyth, F., Rochat, S., Cumming, R., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2008). Pain, frailty and comorbidity on older men: The CHAMP study. Pain, 140(1), 224-230. [More Information]
Le Couteur, D., Kendig, H. (2008). Pharmaco-epistemology for the prescribing geriatrician. Australasian Journal on Ageing, 27(1), 3-7. [More Information]
Cheluvappa, R., Shimmon, R., Dawson, M., Hilmer, S., Le Couteur, D. (2008). Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochimica Polonica, 55(3), 571-580. [More Information]
Pearson, K., Baur, J., Lewis, K., Peshkin, L., Price, N., Labinskyy, N., Swindell, W., Kamara, D., Minor, R., et al, Le Couteur, D., Jamieson, H. (2008). Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism, 8(2), 157-168. [More Information]
Martinez, I., Nedredal, G., Oie, C., Warren, A., Johansen, O., Le Couteur, D., Smedsrod, B. (2008). The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells. Comparative Hepatology, 7(4), 1-11. [More Information]
Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]
Le Couteur, D., Cogger, V., McCuskey, R., De Cabo, R., Smedsrod, B., Sorensen, K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. Annals of the New York Academy of Sciences, 1114, 79-87. [More Information]
Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50(9), 1969-1976. [More Information]
Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
Hilmer, S., McLachlan, A., Le Couteur, D. (2007). Clinical pharmacology in the geriatric patient. Fundamental and Clinical Pharmacology, 21(3), 217-230. [More Information]
Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. Annals of the New York Academy of Sciences, 1114, 88-92. [More Information]
Everitt, A., Le Couteur, D. (2007). Life Extension by Calorie Restriction in Humans. Annals of the New York Academy of Sciences, 1114, 428-433. [More Information]
Latimer Hill, E., Cumming, R., Lewis, R., Carrington, S., Le Couteur, D. (2007). Sleep disturbances and falls in older people. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62A(1), 62-66. [More Information]
Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]
Cheluvappa, R., Jamieson, H., Muller, M., Le Couteur, D. (2007). The effect of Pseudomonas aeruginosa virulence factor, pyocyanin, on the liver sinusoidal endothelial cell. Journal of Gastroenterology and Hepatology, 22(8), 1350-1351. [More Information]
Fisher, A., Davis, M., Rubenach, S., Le Couteur, D., McLean, A. (2007). The site-specific epidemiology of hip fracture in the Australian Capital Territory with projections for the first half of the 21st century: Implications for clinical management and health services planning. Australasian Journal on Ageing, 26(1), 45-51. [More Information]
Le Couteur, D., Bailey, L., Naganathan, V. (2006). Beta-blockers and heart failure in older people. European Heart Journal, 27(7), 887-8; author reply 888-9. [More Information]
Everitt, A., Hilmer, S., Brand-Miller, J., Jamieson, H., Truswell, A., Sharma, A., Mason, R., Morris, B., Le Couteur, D. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1(1), 11-31. [More Information]
Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
Baur, J., Pearson, K., Price, N., Jamieson, H., Lerin, C., Kalra, A., Prabhu, V., Allard, J., Lopez-Lluch, G., Lewis, K., Le Couteur, D., et al (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444(7117), 337-342. [More Information]
Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]
Cooper, G., Le Couteur, D., Richardson, D., Buckley, N. (2005). A randomized clinical trial of activated charcoal for the routine management of oral drug overdose. QJM, 98(9), 655-660. [More Information]
Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
Hien, L., Cumming, R., Cameron, I., Chen, J., Lord, S., March, L., Schwarz, J., Le Couteur, D., Sambrook, P. (2005). Atypical antipsychotic medications and risk of falls in residents of aged care facilities. Journal of the American Geriatrics Society, 53(8), 1290-1295. [More Information]
Everitt, A., Roth, G., Le Couteur, D., Hilmer, S. (2005). Calorie restriction versus drug therapy to delay the onset of ageing diseases and extend life. Age, 27(1), 39-48. [More Information]
Park, G., Katelaris, P., Jones, D., Ngu, M., Le Couteur, D. (2005). Caution before embracing serum markers of liver fibrosis in clinical practice. Gastroenterology, 128(4), 1145-1146. [More Information]
Hilmer, S., Shenfield, G., Le Couteur, D. (2005). Clinical Implications of Changes in Hepatic Drug Metabolism in Older People. Therapeutics and Clinical Risk Management, 1(2), 151-156.
Graffen, M., Saligari, M., Le Couteur, D., Naganathan, V., McLean, A. (2005). Development of a mentorship programme for rural general practitioners by visiting specialist physicians. Rural and Remote Health, 5(2), 374-374. [More Information]
Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
Harris, M., Le Couteur, D., Arias, I. (2005). Progressive familial intrahepatic cholestasis: genetic disorders of biliary transporters. Journal of Gastroenterology and Hepatology, 20(6), 807-17. [More Information]
Katelaris, P., Jones, B., Lin, B., Le Couteur, D., Ngu, M., Park, G., Seow, F. (2005). The 13C-caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy. Alimentary Pharmacology and Therapeutics, 22(5), 395-403. [More Information]
Fisher, A., Davis, M., Le Couteur, D. (2005). The effect of meals at different mealtimes on blood pressure and symptoms in geriatric patients with postprandial hypotension. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 60(2), 184-5; author reply 185-6. [More Information]
Fisher, A., Davis, M., McLean, A., Le Couteur, D. (2005). The Epidemiology of falls in semi independent residents in residential care. Australasian Journal on Ageing, 24(2), 98-102.
Le Couteur, D., Fraser, R., Hilmer, S., Rivory, L., McLean, A. (2005). The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clinical Pharmacokinetics, 44(2), 187-200. [More Information]
Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.
McLean, A., Le Couteur, D. (2004). Aging Biology And Geriatric Clinical Pharmacology. Pharmacological Reviews, 56(2), 163-184. [More Information]
Whitbread, A., Mellick, G., Silburn, P., Le Couteur, D., Board, P. (2004). Glutathione Transferase Omega Class Polymorphisms In Parkinson Disease. Neurology, 62(10), 1910-1911. [More Information]
Cogger, V., Warren, A., Fraser, R., Ngu, M., McLean, A., Le Couteur, D. (2004). Preliminary Analysis Of The Sinusoidal Endothelium And Space Of Disse In Ageing Papio Hamadrayas. Comparative Hepatology, 3(Suppl 1), S26-S27.
Cumming, R., Glasgow, N., Le Couteur, D., Naganathan, V., Hilmer, S. (2004). Prescribing In Older People. Australian Family Physician, 33(10), 777-781.
Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57. [More Information]
Cogger, V., Muller, M., Fraser, R., McLean, A., Khan, J., Le Couteur, D. (2004). The Effects Of Oxidative Stress On The Liver Sieve. Journal of Hepatology, 41(3), 370-376. [More Information]
Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799. [More Information]
Sullivan, D., Celermajer, D., Le Couteur, D., Lam, C. (2004). The Vascular Implications Of Postprandial Lipoprotein Metabolism. Clinical Biochemist Reviews, 25(1), 19-30.
Le Couteur, D., Yin, Z., McLean, A., Rivory, L. (2004). Wash-In Methodology And Modeling To Determine Hepatocellular D-Glucose Transport In The Perfused Rat Liver. Japanese journal of physiology, 54(4), 421-429. [More Information]
Fisher, A., McLean, A., Davis, M., Le Couteur, D. (2003). A multi-center, case control study of the effects of antihypertensive therapy on orthostatic hypotension, postprandial hypotension and falls in octo-and nonagenarians in residential care facilities. Current Therapeutic Research: Clinical and Experimental, 64(3), 206-214. [More Information]
McLean, A., Cogger, V., Chong, G., Warren, A., Markus, A., Dahlstrom, J., Le Couteur, D. (2003). Age-related pseudocapillarization of the human liver. Journal of Pathology, 200(1), 112-117. [More Information]
Braet, F., Muller, M., Vekemans, K., Wisse, E., Le Couteur, D. (2003). Antimycin A-induced defenestration in rat hepatic sinusoidal endothelial cells. Hepatology, 38(2), 394-402. [More Information]
Cumming, R., Le Couteur, D. (2003). Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs, 17(11), 825-837. [More Information]
Sangalli, M., McLean, A., Peek, M., Rivory, L., Le Couteur, D. (2003). Carbon monoxide disposition and permeability-surface area product in the foetal circulation of the perfused term human placenta. Placenta, 24(1), 8-11. [More Information]
Cogger, V., Warren, A., Fraser, R., Ngu, M., Le Couteur, D., McLean, A. (2003). Hepatic sinusoidal pseudocappilarization with aging in the non-human primate. Experimental Gerontology, 38(10), 1101-1107. [More Information]
Le Couteur, D., Fisher, A., Davis, M., McLean, A. (2003). Postprandial systolic blood pressure responses of older people in residential care: association with risk of falling. Gerontology, 49(4), 260-264. [More Information]
Park, G., Katelaris, P., Jones, D., Seow, F., Le Couteur, D., Ngu, M. (2003). Validity of the 13C-caffeine breath test as a noninvasive, quantitative test of liver function. Hepatology, 38(5), 1227-1236. [More Information]
Hilmer, S., Naganathan, V., Le Couteur, D. (2003). Why do physicians choose to train in geriatric medicine? Australasian Journal on Ageing, 11(3), 160-162.
Croft-Baker, J., Croft-Baker, L., Le Couteur, D., McLean, A. (2002). Age related factors determining safe prescribing for older people. C M E Journal: Geriatric Medicine (CME Geriatric Medicine), 4(1), 4-8.
Le Couteur, D., Muller, M., Yang,, M., Mellick, G., McLean, A. (2002). Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease. Reviews on Environmental Health, 17(1), 51-64.
Yang, M., Mclean, A., Le Couteur, D. (2002). Age-related alteration in hepatic disposition of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and pesticides. Pharmacology and Toxicology, 90(4), 203-207. [More Information]
Andrews, G., Khalil, Z., Le Couteur, D. (2002). Aging research worldwide: Experimental gerontological research in Australia. Experimental Gerontology, 37(12), 1301-1308.
Shenfield, G., Le Couteur, D., Rivory, L. (2002). Clinical pharmacology. Medical Journal of Australia, , 9-9.
Harvey, P., Gready, J., Yin, Z., Le Couteur, D., Mclean, A. (2002). Hepatic phospholipid changes induced by sustained oxygen supplementation. Pharmacology and Toxicology, 91(3), 150-152. [More Information]
Le Couteur, D., Fraser, R., Cogger, V., McLean, A. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. The Lancet, 359(9317), 1612-1615. [More Information]
Buchanan, D., Silburn, P., Chalk, J., Le Couteur, D., Mellick, G. (2002). The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients. Neuroscience Letters, 327(2), 91-94. [More Information]
Cho, S., McLean, A., Rivory, L., Gatenby, P., Le Couteur, D., Hardman,, D. (2001). Carbon monoxide wash-in method to determine gas transfer in vascular beds: application to rat hindlimb. American Journal of Physiology - Heart and Circulatory Physiology, 280.
Cogger, V., Markus, A., Harvey, P., Ansselin, A., McLean, A., Le Couteur, D., Yin,, Z. (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33, 537-543. [More Information]
Cogger, V., Ansselin, A., Le Couteur, D., McLean, A., Mross, P., Hosie, M. (2001). The effect of acute oxidative stress on the ultrastructure of the perfused rat liver. Pharmacology and Toxicology, 89, 306-311. [More Information]
Harvey, P., Gready, J., Yin, Z., Le Couteur, D., McLean, A. (2000). Acute Oxygen Supplementation Restores Markers of Hepatocyte Energy Status and Hypoxia in Cirrhotic Rats. Journal of Pharmacology and Experimental Therapeutics, 293(2), 641-645.
Yang, M., McLean, A., Rivory, L., Le Couteur, D. (2000). Hepatic Disposition of Neurotoxins and Pesticides. Pharmacology and Toxicology, 87(6), 286-291.

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2024

Hilmer, S., Schwartz, J., Petrovic, M., Walker, L., Thürmann, P., Le Couteur, D. (2024). Addressing the gaps in evaluation of new drugs for older adults: Strategies from the International Union of Basic and Clinical Pharmacology (IUPHAR) Geriatric Committee. Journal of the American Geriatrics Society. [More Information]
Luong, R., Ribeiro, R., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Seibel, M., Hirani, V. (2024). Cross-sectional and longitudinal associations between empirically derived dietary patterns and frailty among older men: The Concord Health and Ageing in Men Project. Journal of Nutrition, Health and Aging, 28(1), 100021. [More Information]
Luong, R., Ribeiro, R., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Seibel, M., Hirani, V. (2024). Empirically derived dietary patterns are associated with major adverse cardiovascular events, all-cause mortality, and congestive cardiac failure in older men: The Concord Health and Ageing in Men Project. Journal of Nutrition, Health and Aging, 28(2), 100020. [More Information]
Tran, M., Van Zwieten, A., Kiely, K., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Seibel, M., Waite, L., Cumming, R., Khalatbari Soltani, S. (2024). Intra-generational social mobility and mortality among older men in the Concord Health and Ageing in Men Project: A cohort study. SSM - Population Health, 25, 101581. [More Information]
Hunt, N., Lockwood, G., Heffernan, S., Daymond, J., Ngu, M., Narayanan, R., Westwood, L., Mohanty, B., Esser, L., Williams, C., Kuncic, Z., McCourt, P., Le Couteur, D., Cogger, V. (2024). Oral nanotherapeutic formulation of insulin with reduced episodes of hypoglycaemia. Nature Nanotechnology, 19(4), 534-544. [More Information]
Ribeiro, R., Senior, A., Simpson, S., Tan, J., Raubenheimer, D., Le Couteur, D., Macia, L., Holmes, A., Eberhard, J., O'Sullivan, J., Koay, Y., Kanjrawi, A., Yang, J., Kim, T., Gosby, A. (2024). Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial. Aging Cell, 23(11), e14276. [More Information]
Lockwood, G., Hunt, N., Kockx, M., Kang, S., Le Couteur, D., Cogger, V. (2024). Understanding the Liver’s Role in the Clearance of Aβ40. Livers, 4(2), 253-267. [More Information]

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2023

Luong, R., Ribeiro, R., Hirani, V., Simpson, S., Le Couteur, D., Raubenheimer, D., Gosby, A. (2023). Associations between protein to non-protein ratio and intakes of other dietary components in a cohort aged 65–75 years: the Nutrition for Healthy Living Study. Public Health Nutrition, 26(12), 3023-3037. [More Information]
Das, S., Silver, R., Senior, A., Gilhooly, C., Bhapkar, M., Le Couteur, D. (2023). Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification. Aging Cell, 22(12), e14018. [More Information]
Mao, H., Szafranska, K., Kruse, L., Holte, C., Wolfson, D., Ahluwalia, B., Whitchurch, C., Cole, L., Lockwood, G., Diekmann, R., Le Couteur, D., Cogger, V., McCourt, P. (2023). Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure. Scientific Reports, 13(1). [More Information]
Luong, R., Ribeiro, R., Rangan, A., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Seibel, M., Hirani, V. (2023). Haem Iron Intake Is Associated with Increased Major Adverse Cardiovascular Events, All-Cause Mortality, Congestive Cardiac Failure, and Coronary Revascularisation in Older Men: The Concord Health and Ageing in Men Project. Journal of Nutrition, Health and Aging, 27(7), 559-570. [More Information]
Kiely, K., Khalatbari Soltani, S., Blyth, F., Naganathan, V., Handelsman, D., Waite, L., Le Couteur, D., Mortby, M., Cumming, R., Anstey, K. (2023). Mixed Evidence of an Association between Self-Rated Hearing Difficulties and Falls: Prospective Analysis of Two Longitudinal Studies. Gerontology, 69(1), 98-108. [More Information]
Scott, D., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Waite, L., Hirani, V. (2023). Sarcopenia prevalence and functional outcomes in older men with obesity: Comparing the use of the EWGSOP2 sarcopenia versus ESPEN-EASO sarcopenic obesity consensus definitions. Clinical Nutrition, 42(9), 1610-1618. [More Information]
Wu, L., Das, A., Massudi, H., Li, C., Kim, L., Wong, A., Marinova, M., Sultani, G., Das, A., Youngson, N., Le Couteur, D., et al (2023). SIRT2 transgenic over-expression does not impact lifespan in mice. Aging Cell, 22(12), e14027. [More Information]
Solon-Biet, S., Clark, X., Bell-Anderson, K., Rusu, P., Perks, R., Freire, T., Pulpitel, T., Senior, A., Hoy, A., Aung, O., Le Couteur, D., Raubenheimer, D., Conigrave, A., Simpson, S., et al (2023). Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure. Cell Reports, 42(12). [More Information]
Hilmer, S., Lo, S., Kelly, P., Viney, R., Blyth, F., Le Couteur, D., McLachlan, A., Arora, S., Hossain, L., Gnjidic, D. (2023). Towards Optimizing Hospitalized Older adults' MEdications (TO HOME): Multi-centre study of medication use and outcomes in routine care. British Journal of Clinical Pharmacology. [More Information]

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2022

Eberhard, J., Ruiz, K., Tan, J., Vidanelage, T., Khan, S., Inan Eroglu, E., Adler, C., Simpson, S., Le Couteur, D., Raubenheimer, D., Macia, L., Gosby, A., Ribeiro, R. (2022). A randomized clinical trial to investigate the effect of dietary protein sources on periodontal health. Journal of Clinical Periodontology, 49(4), 388-400. [More Information]
Raubenheimer, D., Senior, A., Mirth, C., Cui, Z., Hou, R., Le Couteur, D., Solon-Biet, S., Léopold, P., Simpson, S. (2022). An integrative approach to dietary balance across the life course. iScience, 25(5). [More Information]
Dai-Keller, Z., Hirani, V., Sahni, S., Felson, D., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Seibel, M., Waite, L., Cumming, R., et al (2022). Association of dietary fiber and risk of hip fracture in men from the Framingham Osteoporosis Study and the Concord Health and Ageing in Men Project. Nutrition and Health, 28(2), 229-238. [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Ribeiro, R., Simpson, S., Hirani, V. (2022). Associations between dietary intake of total protein and sources of protein (plant vs. animal) and risk of all-cause and cause-specific mortality in older Australian men: The Concord Health and Ageing in Men Project. Journal of Human Nutrition and Dietetics, 35(5), 845-860. [More Information]
Le Couteur, D., Anderson, R., de Cabo, R. (2022). Can we make drug discovery targeting fundamental mechanisms of aging a reality? Expert Opinion on Drug Discovery, 17(2), 97-100. [More Information]
Luong, R., Ribeiro, R., Rangan, A., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Le Couteur, D., Hirani, V. (2022). Changes in Dietary Total and Nonheme Iron Intake Is Associated With Incident Frailty in Older Men: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 77(9), 1853-1865. [More Information]
Khalatbari Soltani, S., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Seibel, M., Hirani, V., Wright, F., Waite, L., Cumming, R. (2022). Cohort Profile Update: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology, 51(1), 31-32H. [More Information]
Wu, H., Mach, J., Gnjidic, D., Naganathan, V., Blyth, F., Waite, L., Handelsman, D., Le Couteur, D., Hilmer, S. (2022). Comparing Effects of Polypharmacy on Inflammatory Profiles in Older Adults and Mice: Implications for Translational Aging Research. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 77(7), 1295-1303. [More Information]
Ischia, L., Naganathan, V., Waite, L., Le Couteur, D., Thillainadesan, J. (2022). COVID-19 and geriatric medicine in Australia and New Zealand. Australasian Journal on Ageing, 41(2), 301-308. [More Information]
Chow, E., Hsu, B., Waite, L., Blyth, F., Handelsman, D., Le Couteur, D., Naganathan, V., Stanaway, F. (2022). Diagnostic accuracy of linked administrative data for dementia diagnosis in community-dwelling older men in Australia. BMC Geriatrics, 22(1). [More Information]
Le Couteur, D., Raubenheimer, D., Solon-Biet, S., de Cabo, R., Simpson, S. (2022). Does diet influence aging? Evidence from animal studies. Journal of Internal Medicine. [More Information]
Shu, C., Wright, F., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Stanaway, F. (2022). Does social support predict increased use of dental services in older men? Australian Dental Journal, 67(3), 262-270. [More Information]
Le Couteur, D., Flicker, L., Hilmer, S. (2022). Geriatric medicine and health care for older people in Australia. Age and Ageing, 51(3), 1-4. [More Information]
Gnanenthiran, S., Ng, A., Cumming, R., Brieger, D., Le Couteur, D., Waite, L., Seibel, M., Handelsman, D., Naganathan, V., Kritharides, L., Blyth, F. (2022). Hemoglobin, Frailty, and Long-term Cardiovascular Events in Community-Dwelling Older Men Aged ≥ 70 Years. Canadian Journal of Cardiology, 38(6), 745-753. [More Information]
Solon-Biet, S., Griffiths, L., Fosh, S., Le Couteur, D., Simpson, S., Senior, A. (2022). Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents. BMC Biology, 20(1), 19. [More Information]
Senior, A., Legault, V., Lavoie, F., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D., Simpson, S., Cohen, A. (2022). Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology, 20(1), Article 196-17 pages. [More Information]
Hunt, N., McCourt, P., Kuncic, Z., Le Couteur, D., Cogger, V. (2022). Opportunities and Challenges for Nanotherapeutics for the Aging Population. Global Journal of Emerging Market Economies, 4, 832524. [More Information]
Mach, J., Allore, H., Gnjidic, D., Gemikonakli, G., Kane, A., Howlett, S., de Cabo, R., Le Couteur, D., Hilmer, S. (2022). Preclinical frailty assessments: Phenotype and frailty index identify frailty in different mice and are variably affected by chronic medications. Experimental Gerontology, 161, 111700. [More Information]
Xu, P., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., Seibel, M., Le Couteur, D., Waite, L., Khalatbari Soltani, S. (2022). Socioeconomic Inequalities in Elective and Nonelective Hospitalizations in Older Men. JAMA Network Open, 5(4), e226398. [More Information]
Hunt, N., Wahl, D., Westwood, L., Lockwood, G., Le Couteur, D., Cogger, V. (2022). Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics. Advanced Drug Delivery Reviews, 190. [More Information]
Le Couteur, D., Thillainadesan, J. (2022). What Is an Aging-Related Disease? An Epidemiological Perspective. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 77(11), 2168-2174. [More Information]
Thillainadesan, J., Le Couteur, D., Haq, I., Wilkinson, T. (2022). When I say … microlearning. Medical Education, 56(8), 791-792. [More Information]

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2021

Takehara, S., Wright, F., Naganathan, V., Hirani, V., Blyth, F., Le Couteur, D., Waite, L., Seibel, M., Handelsman, D., Cumming, R. (2021). A Cross-Sectional Study of Perceived Dental Treatment Needs and Oral Health Status in Community-Dwelling Older Australian Men: The Concord Health and Ageing in Men Project. International Dental Journal, 71(3), 224-232. [More Information]
Cervo, M., Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Ribeiro, R., Waite, L., Hirani, V. (2021). Adherence to Mediterranean diet and its associations with circulating cytokines, musculoskeletal health and incident falls in community-dwelling older men: The Concord Health and Ageing in Men Project. Clinical Nutrition, 40(12), 5753-5763. [More Information]
Takehara, S., Hirani, V., Wright, F., Naganathan, V., Blyth, F., Le Couteur, D., Waite, L., Seibel, M., Handelsman, D., Cumming, R. (2021). Appetite, oral health and weight loss in community-dwelling older men: an observational study from the Concord Health and Ageing in Men Project (CHAMP). BMC Geriatrics, 21(1), 1-9. [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Ribeiro, R., Simpson, S., Hirani, V. (2021). Associations between nutrient intakes and dietary patterns with different sarcopenia definitions in older Australian men: the concord health and ageing in men project. Public Health Nutrition, 24(14), 4490-4505. [More Information]
Milledge, K., Cumming, R., Wright, F., Naganathan, V., Blyth, F., Le Couteur, D., Waite, L., Handelsman, D., Hirani, V. (2021). Associations between the composition of functional tooth units and nutrient intake in older men: The Concord Health and Ageing in Men Project. Public Health Nutrition, 24(18), 6335-6345. [More Information]
Wali, J., Raubenheimer, D., Senior, A., Le Couteur, D., Simpson, S. (2021). Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry. Cardiovascular Research, 117(2), 386-401. [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Ribeiro, R., Waite, L., Simpson, S., Hirani, V. (2021). Changes in micronutrient intake and factors associated with this change among older Australian men: The Concord Health and Ageing in Men Project. Public Health Nutrition, 24(14), 4454-4465. [More Information]
Mach, J., Gemikonakli, G., Logan, C., Wyk, B., Allore, H., Ekambareshwar, S., Kane, A., Howlett, S., de Cabo, R., Le Couteur, D., Hilmer, S. (2021). Chronic polypharmacy with increasing drug burden index exacerbates frailty and impairs physical function, with effects attenuated by deprescribing, in aged mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(6), 1010-1018. [More Information]
Ng, B., Duong, M., Lo, S., Le Couteur, D., Hilmer, S. (2021). Deprescribing perceptions and practice reported by multidisciplinary hospital clinicians after, and by medical students before and after, viewing an e-learning module. Research in Social and Administrative Pharmacy, 17(11), 1997-2005. [More Information]
Hilmer, S., Petrovic, M., Le Couteur, D., Schwartz, J., Thuermann, P. (2021). Development, evaluation and use of COVID-19 vaccines in older adults: Preliminary principles for the pandemic and beyond. British Journal of Clinical Pharmacology, 87(9), 3459-3461. [More Information]
Stanaway, F., Ribeiro, R., Khalatbari Soltani, S., Cvejic, E., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D., Simpson, S., Waite, L., Cumming, R., Hirani, V. (2021). Diet quality in an ethnically diverse population of older men in Australia. European Journal of Clinical Nutrition, 51(1). [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Ribeiro, R., Simpson, S., Hirani, V. (2021). Dietary and supplemental antioxidant intake and risk of major adverse cardiovascular events in older men: The concord health and ageing in men project. Nutrition, Metabolism & Cardiovascular Diseases, 31(4), 1102-1112. [More Information]
Ng, C., Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Waite, L., Handelsman, D., Hirani, V. (2021). Higher-Impact Physical Activity Is Associated With Maintenance of Bone Mineral Density But Not Reduced Incident Falls or Fractures in Older Men: The Concord Health and Aging in Men Project. Journal of Bone and Mineral Research, 36(4), 662-672. [More Information]
Wali, J., Milner, A., Luk, A., Pulpitel, T., Dodgson, T., Facey, H., Wahl, D., Kebede, M., Senior, A., Sullivan, M., Brandon, A., Yau, B., Lockwood, G., Koay, Y., Ribeiro, R., Solon-Biet, S., Bell-Anderson, K., O'Sullivan, J., Macia, L., Cooney, G., Cogger, V., Holmes, A., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3(6), 810-828. [More Information]
Duong, M., McLachlan, A., Bennett, A., Jokanovic, N., Le Couteur, D., Baysari, M., Gnjidic, D., Blyth, F., Hilmer, S. (2021). Iterative Development of Clinician Guides to Support Deprescribing Decisions and Communication for Older Patients in Hospital: A Novel Methodology. Drugs and Aging, 38(1), 75-87. [More Information]
Fotheringham, A., Solon-Biet, S., Bielefeldt-Ohmann, H., McCarthy, D., McMahon, A., Ruohonen, K., Li, I., Sullivan, M., Whiddett, R., Borg, D., Cogger, V., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2021). Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 24(11), 103308. [More Information]
Hew, J., Parugano, R., Mooney, C., Smyth, J., Kim, S., Tsai, K., Chong, C., Chan, R., Attia, B., Nicholls, C., Li, Z., Solon-Biet, S., Le Couteur, D., Simpson, S., Maitz, P., Wang, Y., et al (2021). Low-protein diet accelerates wound healing in mice post-acute injury. Burns & Trauma, 9, tkab010. [More Information]
Wahl, D., Gokarn, R., Solon-Biet, S., Cogger, V., LaRocca, T., Raubenheimer, D., Simpson, S., Le Couteur, D. (2021). Modelling nutrition and brain aging rodents. In Martin CR, Preedy VR, Rajendram R (Eds.), Assessments, Treatments and Modelling in Aging and Neurological Disease: The Neuroscience of Aging, (pp. 517-526). London: Academic Press. [More Information]
Wu, H., Le Couteur, D., Hilmer, S. (2021). Mortality trends of stroke and dementia: Changing landscapes and new challenges. Journal of the American Geriatrics Society, 69(10), 2888-2898. [More Information]
Wu, H., Mach, J., Le Couteur, D., Hilmer, S. (2021). Nationwide mortality trends of delirium in Australia and the United States from 2006 to 2016. Australasian Journal on Ageing, 40(4), e279-e286. [More Information]
Le Couteur, D., Solon-Biet, S., Parker, B., Pulpitel, T., Brandon, A., Hunt, N., Wali, J., Gokarn, R., Senior, A., Cooney, G., Raubenheimer, D., James, D., Simpson, S., et al (2021). Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin. Cell Metabolism, 33(12), 2367-2379.e4. [More Information]
Wu, H., Mach, J., Gemikonakli, G., Tran, T., Allore, H., Gnjidic, D., Howlett, S., de Cabo, R., Le Couteur, D., Hilmer, S. (2021). Polypharmacy Results in Functional Impairment in Mice: Novel Insights into Age and Sex Interations. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(10), 1748-1756. [More Information]
Wu, H., Mach, J., Le Couteur, D., Hilmer, S. (2021). Prevalence and risk factors of food insecurity among Libyan migrant families in Australia. BMC Public Health, 21(1), 2156. [More Information]
Scott, D., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Seibel, M., Waite, L., Hirani, V. (2021). Prospective associations of chronic and intrusive pain with sarcopenia and physical disability amongst older Australian men: The Concord Health and Ageing in Men Project. Experimental Gerontology, 153, 111501. [More Information]
Hunt, N., Lockwood, G., Kang, S., Westwood, L., Limantoro, C., Chrzanowski, W., McCourt, P., Kuncic, Z., Le Couteur, D., Cogger, V. (2021). Quantum Dot Nanomedicine Formulations Dramatically Improve Pharmacological Properties and Alter Uptake Pathways of Metformin and Nicotinamide Mononucleotide in Aging Mice. ACS Nano, 15(3), 4710-4727. [More Information]
Mesinovic, J., Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Waite, L., Handelsman, D., Hirani, V. (2021). Risk factors for incident falls and fractures in older men with and without type 2 diabetes mellitus: The concord health and ageing in men project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(6), 1090-1100. [More Information]
Le Couteur, D., Handelsman, D., Stanaway, F., Waite, L., Blyth, F., Naganathan, V., Cumming, R., Hirani, V. (2021). Sarcopenic obesity and amino acids: Concord health and ageing in men project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(6), 1000-1004. [More Information]
Das, A., Cumming, R., Naganathan, V., Ribeiro, R., Le Couteur, D., Handelsman, D., Waite, L., Hirani, V. (2021). The association between antioxidant intake, dietary pattern and depressive symptoms in older Australian men: the Concord Health and Ageing in Men Project. European Journal of Nutrition, 60(1), 443-454. [More Information]
Khalatbari Soltani, S., Cumming, R., Chomik, R., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D., Waite, L., Stanaway, F. (2021). The association between home ownership and the health of older men: Cross-sectional analysis of the Australian Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 40(3), e199-e206. [More Information]
Khalatbari Soltani, S., Stanaway, F., Sherrington, C., Blyth, F., Naganathan, V., Handelsman, D., Seibel, M., Waite, L., Le Couteur, D., Cumming, R. (2021). The Prospective Association Between Socioeconomic Status and Falls Among Community-Dwelling Older Men. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(10), 1821-1828. [More Information]
Scott, D., Hirani, V., Waite, L., Blyth, F., Le Couteur, D., Cumming, R., Jones, G. (2021). ‘Giant’ Claims Require Strong Evidence: A Comment on ‘Osteosarcopenia: A Geriatric Giant of the XXI Century’. Journal of Nutrition, Health and Aging, 25(7), 946-947. [More Information]

show 28 more

2020

Johansen, M., Irving, A., Montagutelli, X., Tate, M., Rudloff, I., Nold, M., Hansbro, N., Kim, R., Donovan, C., Liu, G., McCaughan, G., Gorrell, M., Cole, A., Moreno, C., Le Couteur, D., Hesselson, D., Triccas, J., Neely, G., Gamble, J., Simpson, S., et al (2020). Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology, 13(6), 877-891. [More Information]
Wahl, D., Anderson, R., Le Couteur, D. (2020). Antiaging Therapies, Cognitive Impairment, and Dementia. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(9), 1643-1652. [More Information]
Le Couteur, D., Stanaway, F., Waite, L., Cullen, J., Lindley, R., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D. (2020). Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(10), 1858-1862. [More Information]
Wright, F., Takehara, S., Stanaway, F., Naganathan, V., Blyth, F., Hirani, V., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M., Cumming, R. (2020). Associations between oral health and depressive symptoms: Findings from the Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 39(3), e306-e314. [More Information]
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Hsu, B., Waite, L., Hirani, V. (2020). Associations of Body Composition Trajectories with Bone Mineral Density, Muscle Function, Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(5), 939-945. [More Information]
Le Couteur, D., Solon-Biet, S., Cogger, V., Ribeiro, R., De Cabo, R., Raubenheimer, D., Cooney, G., Simpson, S. (2020). Branched chain amino acids, aging and age-related health. Ageing Research Reviews, 64, 1-11. [More Information]
Le Couteur, D., Ribeiro, R., Senior, A., Hsu, B., Hirani, V., Blyth, F., Waite, L., Simpson, S., Naganathan, V., Cumming, R., et al (2020). Branched Chain Amino Acids, Cardiometabolic Risk Factors and Outcomes in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(10), 1805-1810. [More Information]
Handelsman, D., Desai, R., Seibel, M., Le Couteur, D., Cumming, R. (2020). Circulating Sex Steroid Measurements of Men by Mass Spectrometry Are Highly Reproducible after Prolonged Frozen Storage. Journal of Steroid Biochemistry and Molecular Biology, 197, 105528. [More Information]
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Hsu, B., Waite, L., Hirani, V. (2020). Comparison of clinical risk factors for incident fracture in obese and non-obese community-dwelling older men. Bone, 137, 1-9. [More Information]
Khalatbari Soltani, S., Stanaway, F., Cvejic, E., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D., Seibel, M., Waite, L., Cumming, R. (2020). Contribution of psychosocial factors to socioeconomic inequalities in mortality among older Australian men: A population-based cohort study. International Journal for Equity in Health, 19(1), 1-12. [More Information]
Le Couteur, D., Anderson, R., Newman, A. (2020). COVID-19 Through the Lens of Gerontology. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(9), e119-e120. [More Information]
Bernier, M., Mitchell, S., Wahl, D., Diaz, A., Singh, A., Seo, W., Wang, M., Ali, A., Kaiser, T., Price, N., Warren, A., Harney, D., Koay, Y., Mach, J., Pulpitel, T., O'Sullivan, J., Larance, M., Le Couteur, D., Cogger, V., et al (2020). Disulfiram Treatment Normalizes Body Weight in Obese Mice. Cell Metabolism, 32(2), 203-214.e4. [More Information]
Bernier, M., Harney, D., Koay, Y., Diaz, A., Singh, A., Wahl, D., Pulpitel, T., Ali, A., Guiterrez, V., Mitchell, S., Mach, J., Le Couteur, D., Cogger, V., O'Sullivan, J., Larance, M., et al (2020). Elucidating the mechanisms by which disulfiram protects against obesity and metabolic syndrome. NPJ Aging and Mechanisms of Disease, 6(1), 8. [More Information]
Wu, H., Mach, J., Le Couteur, D., Hilmer, S. (2020). Fall-related mortality trends in Australia and the United Kingdom: Implications for research and practice. Maturitas, 142, 68-72. [More Information]
Hsu, B., Naganathan, V., Blyth, F., Hirani, V., Le Couteur, D., Waite, L., Seibel, M., Handelsman, D., Cumming, R. (2020). Frailty and Cause-Specific Hospitalizations in Community-Dwelling Older Men. Journal of Nutrition, Health and Aging, 24(6), 563-569. [More Information]
Valdez, E., Wright, F., Naganathan, V., Milledge, K., Blyth, F., Hirani, V., Le Couteur, D., Handelsman, D., Waite, L., Cumming, R. (2020). Frailty and oral health: Findings from the Concord Health and Ageing in Men Project. Gerodontology, 37(1), 28-37. [More Information]
Thillainadesan, J., Scott, I., Le Couteur, D. (2020). Frailty, a multisystem ageing syndrome. Age and Ageing, 49(5), 758-763. [More Information]
Tsai, K., Shi, H., Ma, D., Nicholls, C., PublicationsHarvesting, T., Solon-Biet, S., D'Souza, M., Le Couteur, D., Simpson, S., Maitz, P., Wang, Y. (2020). Geometric framework reveals that a moderate protein, high carbohydrate intake is optimal for severe burn injury in mice. British Journal of Nutrition, 123(9), 1056-1067. [More Information]
Hide, D., Warren, A., Fernández-Iglesias, A., Maeso-Díaz, R., Peralta, C., Le Couteur, D., Bosch, J., Cogger, V., Gracia-Sancho, J. (2020). Ischemia/reperfusion injury in the aged liver: The importance of the sinusoidal endothelium in developing therapeutic strategies for the elderly. Heart, Lung, and Circulation, 75(2), 268-277. [More Information]
Gnanenthiran, S., Ng, A., Cumming, R., Brieger, D., Le Couteur, D., Waite, L., Handelsman, D., Naganathan, V., Kritharides, L., Blyth, F. (2020). Low total cholesterol is associated with increased major adverse cardiovascular events in men aged >70 years not taking statins. Heart, 106(9), 698-705. [More Information]
Stanaway, F., Blyth, F., Naganathan, V., Le Couteur, D., Ribeiro, R., Hirani, V., Waite, L., Handelsman, D., Seibel, M., Cumming, R. (2020). Mortality Paradox of Older Italian-Born Men in Australia: The Concord Health and Ageing in Men Project. Journal of Immigrant and Minority Health, 22(1), 102-109. [More Information]
Bertoldo, M., Listijono, D., Ho, W., Riepsamen, A., Goss, D., Richani, D., Jin, X., Mahbub, S., Campbell, J., Habibalahi, A., Le Couteur, D., et al (2020). NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell Reports, 30(6), 1670-1681. [More Information]
Cumming, R., Khalatbari Soltani, S., Blyth, F., Naganathan, V., Le Couteur, D. (2020). Not all older men have the chronic diseases associated with severe COVID-19. Australasian Journal on Ageing, 39(4), 381-382. [More Information]
Takehara, S., Wright, F., Waite, L., Naganathan, V., Hirani, V., Blyth, F., Le Couteur, D., Seibel, M., Handelsman, D., Cumming, R. (2020). Oral health and cognitive status in the Concord Health and Ageing in Men Project: A cross-sectional study in community-dwelling older Australian men. Gerodontology, 37(4), 353-360. [More Information]
Ford, G., Lord, J., Ferguson, M., Bountra, C., Le Couteur, D. (2020). Organizational innovation for developing new medicines that target aging and age-related conditions. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(1), 87-88. [More Information]
Cervo, M., Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Ribeiro, R., Waite, L., Hirani, V., et al (2020). Proinflammatory Diet Increases Circulating Inflammatory Biomarkers and Falls Risk in Community-Dwelling Older Men. The Journal of Nutrition, 150(2), 373-381. [More Information]
Das, A., Cumming, R., Naganathan, V., Blyth, F., Ribeiro, R., Le Couteur, D., Handelsman, D., Waite, L., Simpson, S., Hirani, V. (2020). Prospective Associations Between Dietary Antioxidant Intake and Frailty in Older Australian Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(2), 348-356. [More Information]
Hunt, N., Lockwood, G., Le Couteur, F., McCourt, P., Singla, N., Kang, S., Burgess, A., Kuncic, Z., Le Couteur, D., Cogger, V. (2020). Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots. ACS Nano, 14(2), 1492-1507. [More Information]
Freire, T., Senior, A., Perks, R., Pulpitel, T., Clark, X., Brandon, A., Wahl, D., Hatchwell, L., Le Couteur, D., Cooney, G., Larance, M., Simpson, S., Solon-Biet, S. (2020). Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice. Journal of Physiology, 598(11), 2081-2092. [More Information]
Khalatbari Soltani, S., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D., Seibel, M., Waite, L., Cvejic, E., Cumming, R. (2020). Socioeconomic status, health-related behaviours, and death among older people: The Concord health and aging in men project prospective cohort study. BMC Geriatrics, 20(1), 261. [More Information]
Hunt, N., Lockwood, G., Kang, S., Pulpitel, T., Clark, X., Mao, H., McCourt, P., Cooney, G., Wali, J., Le Couteur, F., Le Couteur, D., Cogger, V. (2020). The effects of metformin on age-related changes in the liver sinusoidal endothelial cell. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(2), 278-285. [More Information]

show 28 more

2019

Wahl, D., Solon-Biet, S., Cogger, V., Fontana, L., Simpson, S., Le Couteur, D., Ribeiro, R. (2019). Aging, lifestyle and dementia. Neurobiology of Disease, 130, 1-15. [More Information]
Thomas, R., Sims, R., Beller, E., Scott, A., Doust, J., Le Couteur, D., Pond, D., Loy, C., Forlini, C., Glasziou, P. (2019). An Australian community jury to consider case-finding for dementia: Differences between informed community preferences and general practice guidelines. Health Expectations, 22(3), 475-484. [More Information]
Narayan, S., Pearson, S., Litchfield, M., Le Couteur, D., Buckley, N., McLachlan, A., Zoega, H. (2019). Anticholinergic medicines use among older adults before and after initiating dementia medicines. British Journal of Clinical Pharmacology, 85(9), 1957-1963. [More Information]
Solon-Biet, S., Cogger, V., Pulpitel, T., Wahl, D., Clark, X., Bagley, E., Gregoriou, G., Senior, A., Wang, Q., Brandon, A., Perks, R., O'Sullivan, J., Koay, Y., Bell-Anderson, K., Kebede, M., Yau, B., Atkinson, C., Dodgson, T., Wali, J., Raubenheimer, D., Cooney, G., Le Couteur, D., Simpson, S., et al (2019). Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism, 1(5), 532-545. [More Information]
Shu, C., Hsu, B., Cumming, R., Blyth, F., Waite, L., Le Couteur, D., Handelsman, D., Naganathan, V. (2019). Caregiving and all-cause mortality in older men 2005-15: the Concord Health and Ageing in Men Project. Age and Ageing, 48(4), 571-576. [More Information]
Wahl, D., Gokarn, R., Mitchell, S., Solon-Biet, S., Cogger, V., Simpson, S., Le Couteur, D., de Cabo, R. (2019). Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice. Nutrition and Healthy Aging, 5(2), 111-117. [More Information]
Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., de Cabo, R., Jones, B., Hilmer, S. (2019). Corrigendum to: The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(3), 332. [More Information]
Mao, H., Diekmann, R., Liang, H., Cogger, V., Le Couteur, D., Lockwood, G., Hunt, N., Schuttpelz, M., Huser, T., Chen, V., et al (2019). Cost-efficient nanoscopy reveals nanoscale architecture of liver cells and platelets. Nanophotonics, 8(7), 1299-1313. [More Information]
Hsu, B., Hirani, V., Cumming, R., Naganathan, V., Blyth, F., Wright, F., Waite, L., Seibel, M., Handelsman, D., Le Couteur, D. (2019). Cross-sectional and Longitudinal Relationships between Inflammatory Biomarkers and Frailty in Community-dwelling Older Men: the Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(6), 835-841. [More Information]
Gaddam, R., Chambers, S., Fraser, R., Cogger, V., Le Couteur, D., Ishii, I., Bhatia, M. (2019). Cystathionine-Gamma-Lyase-Derived Hydrogen Sulfide-Regulated Substance P Modulates Liver Sieve Fenestrations in Caecal Ligation and Puncture-Induced Sepsis. International Journal of Molecular Sciences, 20(13), 1-9. [More Information]
Baysari, M., Duong, M., Zheng, W., Nguyen, A., Lo, S., Ng, B., Ritchie, A., Le Couteur, D., McLachlan, A., Bennett, A., Hilmer, S. (2019). Delivering the right information to the right person at the right time to facilitate deprescribing in hospital: a mixed methods multisite study to inform decision support design in Australia. BMJ Open, 9(9), 1-9. [More Information]
Wali, J., Milner, A., Pulpitel, T., Koay, Y., Brandon, A., Kebede, M., Dodgson, T., O'Sullivan, M., Wahl, D., Yau, B., O'Sullivan, J., Solon-Biet, S., Cooney, G., Cogger, V., Le Couteur, D., Simpson, S., et al (2019). Determining the metabolic impact of dietary carbohydrate composition in the setting of low, medium and high protein diets. Obesity Research & Clinical Practice, 13(3), 296. [More Information]
Jokanovic, N., Aslani, P., Carter, S., Duong, M., Gnjidic, D., Jansen, J., Le Couteur, D., Hilmer, S. (2019). Development of consumer information leaflets for deprescribing in older hospital inpatients: A mixed-methods study. BMJ Open, 9(12), 1-18. [More Information]
Senior, A., Solon-Biet, S., Cogger, V., Le Couteur, D., Nakagawa, S., Raubenheimer, D., Simpson, S. (2019). Dietary macronutrient content, age-specific mortality and lifespan. Proceedings of the Royal Society B: Biological Sciences, 286(1902), 1-9. [More Information]
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Hirani, V. (2019). Does Combined Osteopenia/Osteoporosis and Sarcopenia Confer Greater Risk of Falls and Fracture Than Either Condition Alone in Older Men? The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 74(6), 827-834. [More Information]
Scott, I., Hilmer, S., Le Couteur, D. (2019). Going Beyond the Guidelines in Individualising the Use of Antihypertensive Drugs in Older Patients. Drugs and Aging, 36(8), 675-685. [More Information]
Hunt, N., Kang, S., Lockwood, G., Le Couteur, D., Cogger, V. (2019). Hallmarks of Aging in the Liver. Computational and Structural Biotechnology Journal, 17, 1151-1161. [More Information]
Kashyap, M., Thuermann, P., Le Couteur, D., Abernathy, D., Hilmer, S. (2019). IUPHAR International geriatric clinical pharmacology curriculum for medical students. Pharmacological Research, 141, 611-615. [More Information]
Hunt, N., Lockwood, G., Warren, A., Mao, H., McCourt, P., Le Couteur, D., Cogger, V. (2019). Manipulating fenestrations in young and old liver sinusoidal endothelial cells. American Journal of Physiology: Gastrointestinal and Liver Physiology, 316(1), G144-G154. [More Information]
Kang, S., Cogger, V., Le Couteur, D., Fu, D. (2019). Multiple cellular pathways regulate lipid droplet homeostasis for the establishment of polarity in collagen sandwich-cultured hepatocytes. American Journal of Physiology: Cell Physiology, 317(5), C942-C952. [More Information]
Ribeiro, R., Solon-Biet, S., Pulpitel, T., Senior, A., Cogger, V., Clark, X., O'Sullivan, J., Koay, Y., Hirani, V., Blyth, F., Seibel, M., Naganathan, V., Cumming, R., Handelsman, D., Simpson, S., Le Couteur, D., et al (2019). Of older mice and men: Branched-chain amino acids and body composition. Nutrients, 11(8), 1-11. [More Information]
Tran, J., Wright, F., Takara, S., Shu, C., Chu, S., Naganathan, V., Hirani, V., Blyth, F., Le Couteur, D., Waite, L., Handelsman, D., Seibel, M., Milledge, K., Cumming, R. (2019). Oral health behaviours of older Australian men: the Concord Health and Ageing in Men Project. Australian Dental Journal, 64(3), 246-255. [More Information]
Morimoto, J., Senior, A., Ruiz, K., Wali, J., Pulpitel, T., Solon-Biet, S., Cogger, V., Raubenheimer, D., Le Couteur, D., Simpson, S., Eberhard, J. (2019). Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS One, 14(3), 1-10. [More Information]
Simpson, S., Le Couteur, D. (2019). The diet and the damage done. Nature Metabolism, 1(11), 1030-1031. [More Information]
Ribeiro, R., Simpson, S., Le Couteur, D., Raubenheimer, D., Eberhard, J., Ruiz, K., Macia, L., Todorova, Y., Gosby, A. (2019). The nutrition for healthy living study: A randomised clinical trial assessing the effect of protein sources on healthy ageing. Nutrition and Healthy Aging, 5(1), 43-51. [More Information]

show 22 more

2018

Le Couteur, D., Simpson, S. (2018). 90th Anniversary Commentary: Caloric Restriction Effects on Aging. The Journal of Nutrition, 148(10), 1656-1659. [More Information]
Solon-Biet, S., Wahl, D., Raubenheimer, D., Le Couteur, D., Simpson, S., Cogger, V. (2018). A Framework for Uncovering the Roles of Calories and Macronutrients in Health and Aging. In Jeffrey L. Ram, P. Michael Conn (Eds.), Conn's Handbook of Models for Human Aging - Second Edition, (pp. 93-108). London: Academic Press. [More Information]
Zunzarren Megale, R., Ferreira, M., Ferreira, P., Naganathan, V., Cumming, R., Hirani, V., Waite, L., Seibel, M., Le Couteur, D., Handelsman, D., Blyth, F. (2018). Association between pain and the frailty phenotype in older men: Longitudinal results from the Concord Health and Ageing in Men Project (CHAMP). Age and Ageing, 47(3), 381-387. [More Information]
Nishtala, P., Chyou, T., Held, F., Le Couteur, D., Gnjidic, D. (2018). Association rules method and big data: Evaluating frequent medication combinations associated with fractures in older adults. Pharmacoepidemiology and Drug Safety, 27(10), 1123-1130. [More Information]
Nair-Shalliker, V., Eager, S., Chrzanowska, A., Mason, R., Waite, L., Le Couteur, D., Seibel, M., Handelsman, D., Cumming, R., Smith, D., Armstrong, B. (2018). Associations between sun sensitive pigmentary genes and serum prostate specific antigen levels. PloS One, 13(3), 1-12. [More Information]
Scott, D., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Seibel, M., Waite, L., Hirani, V. (2018). Associations of sarcopenic obesity with the metabolic syndrome and insulin resistance over five years in older men: The Concord Health and Ageing in Men Project. Experimental Gerontology, 108, 99-105. [More Information]
Hsu, B., Bleicher, K., Waite, L., Naganathan, V., Blyth, F., Handelsman, D., Le Couteur, D., Seibel, M., Cumming, R. (2018). Community-dwelling older men with dementia are at high risk of hip fracture, but not any other fracture: The Concord Health and Aging in Men Project. Geriatrics and Gerontology International, 18(10), 1479-1484. [More Information]
Wahl, D., Solon-Biet, S., Wang, K., Wali, J., Pulpitel, T., Clark, X., Raubenheimer, D., Senior, A., Sinclair, D., Cooney, G., Cogger, V., Simpson, S., Le Couteur, D., et al (2018). Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Reports, 25(8), 2234-2243.e6. [More Information]
Ng, B., Le Couteur, D., Hilmer, S. (2018). Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients. Drugs & Aging, 35(6), 493-521. [More Information]
Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Le Couteur, D., Seibel, M., Handelsman, D. (2018). Evaluating Calculated Free Testosterone as a Predictor of Morbidity and Mortality Independent of Testosterone for Cross-sectional and 5-Year Longitudinal Health Outcomes in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(6), 729-736. [More Information]
Wahl, D., Bernier, M., Simpson, S., de Cabo, R., Le Couteur, D. (2018). Future directions of resveratrol research. Nutrition and Healthy Aging, 4(4), 287-290. [More Information]
Le Couteur, D., Bateman, B., Brayne, C. (2018). Idalopirdine: Another disappointment for people with dementia. BMJ, 360, 1-2. [More Information]
Anderson, R., Le Couteur, D. (2018). Journal of Gerontology: Biological Sciences. A Long Tradition in Advancing Aging Biology and Translational Gerontology. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(3), 271-272. [More Information]
Gokarn, R., Solon-Biet, S., Cogger, V., Cooney, G., Wahl, D., McMahon, A., Mitchell, J., Mitchell, S., Hine, C., De Cabo, R., Raubenheimer, D., Simpson, S., Le Couteur, D. (2018). Long-term Dietary Macronutrients and Hepatic Gene Expression in Aging Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(12), 1618-1625. [More Information]
Hirani, V., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Hsu, B., Handelsman, D., Waite, L., Seibel, M. (2018). Longitudinal Associations Between Vitamin D Metabolites and Sarcopenia in Older Australian men: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(1), 131-138. [More Information]
Noguchi, N., Chan, L., Cumming, R., Blyth, F., Handelsman, D., Waite, L., Le Couteur, D., Naganathan, V. (2018). Natural history of post-void residual urine volume over 5 years in community-dwelling older men: The Concord Health and Ageing in Men Project. Neurourology and Urodynamics, 37(3), 1068-1073. [More Information]
Hunt, N., McCourt, P., Le Couteur, D., Cogger, V. (2018). Novel targets for delaying aging: The importance of the liver and advances in drug delivery. Advanced Drug Delivery Reviews, 135, 39-49. [More Information]
Wright, F., Chu, S., Milledge, K., Valdez, E., Law, G., Hsu, B., Naganathan, V., Hirani, V., Blyth, F., Le Couteur, D., Waite, L., Handelsman, D., Seibel, M., Cumming, R., et al (2018). Oral health of community-dwelling older Australian men: The Concord Health and Ageing in Men Project (CHAMP). Australian Dental Journal, 63(1), 55-65. [More Information]
Le Couteur, D., Anderson, R., De Cabo, R. (2018). Sex and aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(2), 139-140. [More Information]
Hsu, B., Hirani, V., Waite, L., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Cumming, R., Handelsman, D. (2018). Temporal associations between sexual function and cognitive function in community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 47(6), 900-904. [More Information]
Solon-Biet, S., Wahl, D., Raubenheimer, D., Cogger, V., Le Couteur, D., Simpson, S. (2018). The geometric framework: An approach for studying the impact of nutrition on healthy aging. Drug Discovery Today: Disease Models, 27, 61-68. [More Information]
Simpson, S., Raubenheimer, D., Cogger, V., Macia, L., Solon-Biet, S., Le Couteur, D., George, J. (2018). The nutritional geometry of liver disease including non-alcoholic fatty liver disease (NAFLD). Journal of Hepatology, 68(2), 316-325. [More Information]
Gokarn, R., Solon-Biet, S., Youngson, N., Wahl, D., Cogger, V., McMahon, A., Cooney, G., Ballard, J., Raubenheimer, D., Morris, M., Simpson, S., Le Couteur, D. (2018). The Relationship Between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(4), 446-449. [More Information]
Hsu, B., Merom, D., Blyth, F., Naganathan, V., Hirani, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2018). Total Physical Activity, Exercise Intensity, and Walking Speed as Predictors of All-Cause and Cause-Specific Mortality Over 7 Years in Older Men: The Concord Health and Aging in Men Project. Journal of the American Medical Directors Association (JAMDA), 19(3), 216-222. [More Information]

show 21 more

2017

Kane, A., Huizer-Pajkos, A., Mach, J., Mitchell, S., de Cabo, R., Le Couteur, D., Howlett, S., Hilmer, S. (2017). A Comparison of Two Mouse Frailty Assessment Tools. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 904-910. [More Information]
Sierro, F., Evrard, M., Rizzetto, S., Melino, M., Mitchell, A., Florido, M., Beattie, L., Walters, S., Tay, S., Lu, B., Roediger, B., Wong, Y., Warren, A., Ritchie, W., McGuffog, C., Weninger, W., Le Couteur, D., Britton, W., Saunders, B., McCaughan, G., Bowen, D., Bertolino, P., et al (2017). A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment. Immunity, 47(2), 374-388. [More Information]
Anderson, R., Le Couteur, D., de Cabo, R. (2017). Caloric Restriction Research: New Perspectives on the Biology of Aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 73(1), 1-3. [More Information]
Wahl, D., Coogan, S., Solon-Biet, S., de Cabo, R., Haran, J., Raubenheimer, D., Cogger, V., Mattson, M., Simpson, S., Le Couteur, D. (2017). Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia. Clinical Interventions in Aging, 12, 1419-1428. [More Information]
Le Couteur, D., Wahl, D., Naismith, S. (2017). Comorbidity and vascular cognitive impairment- no dementia (VCI-ND). Age and Ageing, 46(5), 705-707. [More Information]
Ribeiro, R., Hirani, V., Senior, A., Gosby, A., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Kendig, H., Seibel, M., Simpson, S., Stanaway, F., Allman-Farinelli, M., Le Couteur, D. (2017). Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP). British Journal of Nutrition, 118, 130-143. [More Information]
Holmes, A., Chew, Y., Colakoglu, F., Cliff, J., Klaassens, E., Read, M., Solon-Biet, S., McMahon, A., Cogger, V., Ruohonen, K., Raubenheimer, D., Le Couteur, D., Simpson, S. (2017). Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints. Cell Metabolism, 25(1), 140-151. [More Information]
Simpson, S., Le Couteur, D., Raubenheimer, D., Solon-Biet, S., Cooney, G., Cogger, V., Fontana, L. (2017). Dietary protein, aging and nutritional geometry. Ageing Research Reviews, 39, 78-86. [More Information]
Gaddam, R., Fraser, R., Badiei, A., Chambers, S., Cogger, V., Le Couteur, D., Bhatia, M. (2017). Differential effects of kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. [More Information]
Jamsen, K., Gnjidic, D., Hilmer, S., Ilomaki, J., Le Couteur, D., Blyth, F., Handelsman, D., Naganathan, V., Waite, L., Cumming, R., et al (2017). Drug Burden Index and change in cognition over time in community-dwelling older men: the CHAMP study. Annals of Medicine, 49(2), 157-164. [More Information]
Alfaras, I., Mitchell, S., Mora, H., Lugo, D., Warren, A., Navas-Enamorado, I., Hoffmann, V., Hine, C., Mitchell, J., Le Couteur, D., Cogger, V., et al (2017). Health benefits of late-onset metformin treatment every other week in mice. NPJ Aging and Mechanisms of Disease, 3, 1-13. [More Information]
Shu, C., Cumming, R., Kendig, H., Blyth, F., Waite, L., Le Couteur, D., Handelsman, D., Naganathan, V. (2017). Health status, health behaviours and anxiety symptoms of older male caregivers: Findings from the Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 36(2), 151-157. [More Information]
Cogger, V., Mohamad, M., Le Couteur, D. (2017). It's the holes that matter. Aging, 9(11), 2237-2238. [More Information]
Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2017). Longitudinal associations between body composition, sarcopenic obesity and outcomes of frailty, disability, institutionalisation and mortality in community-dwelling older men: The Concord Health and Ageing in men project. Age and Ageing, 46(3), 413-420. [More Information]
Noguchi, N., Chan, L., Cumming, R., Blyth, F., Handelsman, D., Waite, L., Le Couteur, D., Naganathan, V. (2017). Natural history of non-neurogenic overactive bladder and urinary incontinence over 5 years in community-dwelling older men: The concord health and aging in men project. Neurourology and Urodynamics, 36(2), 443-448. [More Information]
Held, F., Le Couteur, D., Blyth, F., Hirani, V., Naganathan, V., Waite, L., Seibel, M., Handelsman, D., Cumming, R., Allore, H., Gnjidic, D. (2017). Polypharmacy in older adults: Association Rule and Frequent-Set Analysis to evaluate concomitant medication use. Pharmacological Research, 116, 39-44. [More Information]
Wright, F., Law, G., Chu, S., Cullen, J., Le Couteur, D. (2017). Residential age care and domiciliary oral health services: Reach-OHT—The development of a metropolitan oral health programme in Sydney, Australia. Gerodontology, 34(4), 420-426. [More Information]
Scott, D., Seibel, M., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Hirani, V. (2017). Sarcopenic Obesity and Its Temporal Associations With Changes in Bone Mineral Density, Incident Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project. Journal of Bone and Mineral Research, 32(3), 575-583. [More Information]
Hsu, B., Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2017). Sexual Function and Mortality in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(4), 520-527. [More Information]
Razi, S., Cogger, V., Kennerson, M., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Hirani, V., Naganathan, V., Waite, L., Cumming, R., Le Couteur, D., et al (2017). SIRT1 Polymorphisms and Serum-Induced SIRT1 Protein Expression in Aging and Frailty: The CHAMP Study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(7), 870-876. [More Information]
Le Couteur, D., Anderson, R., Newman, A., de Cabo, R. (2017). Stem Cell Transplantation for Frailty. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 72(11), 1503-1504. [More Information]
Painter, V., Le Couteur, D., Waite, L. (2017). Texture-modified food and fluids in dementia and residential aged care facilities. Clinical Interventions in Aging, 12, 1193-1203. [More Information]
Simpson, S., Le Couteur, D., James, D., George, J., Gunton, J., Solon-Biet, S., Raubenheimer, D. (2017). The Geometric Framework for Nutrition as a tool in precision medicine. Nutrition and Healthy Aging, 4(3), 217-226. [More Information]

show 20 more

2016

Kane, A., Mitchell, S., Mach, J., Huizer-Pajkos, A., McKenzie, C., Jones, B., Cogger, V., Le Couteur, D., de Cabo, R., Hilmer, S. (2016). Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. Experimental Gerontology, 73, 95-106. [More Information]
Huizer-Pajkos, A., Kane, A., Howlett, S., Mach, J., Mitchell, S., De Cabo, R., Le Couteur, D., Hilmer, S. (2016). Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(5), 571-577. [More Information]
Held, F., Blyth, F., Gnjidic, D., Hirani, V., Naganathan, V., Waite, L., Seibel, M., Rollo, J., Handelsman, D., Cumming, R., Le Couteur, D. (2016). Association Rules Analysis of Comorbidity and Multimorbidity: The Concord Health and Aging in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(5), 625-631. [More Information]
Gaddam, R., Fraser, R., Badiei, A., Chambers, S., Cogger, V., Le Couteur, D., Ishii, I., Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PloS One, 11(8), 1-21. [More Information]
Solon-Biet, S., Cogger, V., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A., Warren, A., Durrant-Whyte, J., Walters, K., Krycer, J., Ponton, F., Gokarn, R., Wali, J., Conigrave, A., James, D., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2016). Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework. Cell Metabolism, 24(4), 555-565. [More Information]
Cogger, V., Mohamad, M., Solon-Biet, S., Senior, A., Warren, A., O'Reilly, J., Tung, B., Svistounov, D., McMahon, A., Fraser, R., Raubenheimer, D., Holmes, A., Simpson, S., Le Couteur, D. (2016). Dietary Macronutrients and the Aging Liver Sinusoidal Endothelial Cell. American Journal of Physiology - Heart and Circulatory Physiology, 310(9), H1064-H1070. [More Information]
Jamsen, K., Bell, J., Hilmer, S., Kirkpatrick, C., Ilomaki, J., Le Couteur, D., Blyth, F., Handelsman, D., Waite, L., Naganathan, V., Cumming, R., Gnjidic, D. (2016). Effects of Changes in Number of Medications and Drug Burden Index Exposure on Transitions between Frailty States and Death: The Concord Health and Ageing in Men Project Cohort Study. Journal of the American Geriatrics Society, 64(1), 89-95. [More Information]
Noguchi, N., Chan, L., Cumming, R., Blyth, F., Handelsman, D., Seibel, M., Waite, L., Le Couteur, D., Naganathan, V. (2016). Lower Urinary Tract Symptoms and Incident Falls in Community Dwelling Older Men: The Concord Health and Ageing in Men Project. The Journal of Urology, 196(6), 1694-1699. [More Information]
Kane, A., Huizer-Pajkos, A., Mach, J., McKenzie, C., Mitchell, S., De Cabo, R., Jones, B., Cogger, V., Le Couteur, D., Hilmer, S. (2016). N-Acetyl Cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. Fundamental and Clinical Pharmacology, 30(3), 263-275. [More Information]
Le Couteur, D., Solon-Biet, S., Wahl, D., Cogger, V., Willcox, B., Willcox, D., Raubenheimer, D., Simpson, S. (2016). New Horizons: Dietary protein, ageing and the Okinawan ratio. Age and Ageing, 45(4), 443-447. [More Information]
Raubenheimer, D., Simpson, S., Le Couteur, D., Solon-Biet, S., Coogan, S. (2016). Nutritional ecology and the evolution of aging. Experimental Gerontology, 86, 50-61. [More Information]
Wahl, D., Cogger, V., Solon-Biet, S., Ribeiro, R., Gokarn, R., Pulpitel, T., de Cabo, R., Mattson, M., Raubenheimer, D., Simpson, S., Le Couteur, D. (2016). Nutritional strategies to optimise cognitive function in the aging brain. Ageing Research Reviews, 31, 80-92. [More Information]
Le Couteur, D., McLachlan, A., Hilmer, S. (2016). Polypharmacy in older people: When should you deprescribe? Medicine Today, 7(6), 16-24.
Noguchi, N., Blyth, F., Waite, L., Naganathan, V., Cumming, R., Handelsman, D., Seibel, M., Le Couteur, D. (2016). Prevalence of the geriatric syndromes and frailty in older men living in the community: The Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 35(4), 255-261. [More Information]
Hsu, B., Seibel, M., Cumming, R., Blyth, F., Naganathan, V., Bleicher, K., Le Couteur, D., Waite, L., Handelsman, D. (2016). Progressive Temporal Change in Serum SHBG, But Not in Serum Testosterone or Estradiol, Is Associated With Bone Loss and Incident Fractures in Older Men: The Concord Health and Ageing in Men Project. Journal of Bone and Mineral Research, 31(12), 2115-2122. [More Information]
Le Couteur, D., Hunter, S., Brayne, C. (2016). Solanezumab and the amyloid hypothesis for Alzheimer's disease. BMJ, 355, 1-2. [More Information]
Hilmer, S., Le Couteur, D. (2016). Standardized, Multidisciplinary Approaches for the Study of Aging Biology and for Translation of Aging Interventions. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 71(4), 425-426. [More Information]
Hsu, B., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Hirani, V., Waite, L., Seibel, M., Handelsman, D. (2016). Temporal Changes in Androgens and Estrogens are associated with All-Cause and Cause-Specific Mortality in Older Men. Journal of Clinical Endocrinology and Metabolism, 10(5), 2201-2210. [More Information]
Hsu, B., Cumming, R., Hirani, V., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2016). Temporal Trend in Androgen Status and Androgen-Sensitive Outcomes in Older Men. Journal of Clinical Endocrinology and Metabolism, 101(4), 1836-1846. [More Information]
Mach, J., Huizer-Pajkos, A., Mitchell, S., McKenzie, C., Phillips, L., Kane, A., Jones, B., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2016). The effect of aging on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundamental and Clinical Pharmacology, 30(1), 23-34. [More Information]
Hew, J., Solon-Biet, S., McMahon, A., Ruohonen, K., Raubenheimer, D., Ballard, J., Le Couteur, D., Nicholls, C., Li, Z., Maitz, P., Wang, Y., Simpson, S. (2016). The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice. PloS One, 11(11), 1-15. [More Information]
Le Couteur, D., Solon-Biet, S., Cogger, V., Mitchell, S., Senior, A., de Cabo, R., Raubenheimer, D., Simpson, S. (2016). The impact of low-protein high-carbohydrate diets on aging and lifespan. Cellular and Molecular Life Sciences, 73(6), 1237-1252. [More Information]
Mohamad, M., Mitchell, S., Wu, L., White, M., Cordwell, S., Mach, J., Solon-Biet, S., Boyer, D., Nines, D., Das, A., Warren, A., Hilmer, S., Simpson, S., Le Couteur, D., Cogger, V., et al (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15(4), 706-715. [More Information]
Aumailley, L., Warren, A., Garand, C., Dubois, M., Paquet, E., Le Couteur, D., Marette, A., Cogger, V., Lebel, M. (2016). Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice. Aging, 8(3), 458-483. [More Information]

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2015

Cogger, V., O'Reilly, J., Warren, A., Le Couteur, D. (2015). A standardized method for the analysis of liver sinusoidal endothelial cells and their fenestrations by scanning electron microscopy. Journal of Visualized Experiments, 30(98), 1-9. [More Information]
Hirani, V., Blyth, F., Naganathan, V., Cumming, R., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2015). Active vitamin D (1,25 dihydroxyvitamin D) is associated with chronic pain in older Australian men: the Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70(3), 387-395. [More Information]
Ribeiro, R., Cumming, R., Blyth, F., Naganathan, V., Allman-Farinelli, M., Le Couteur, D., Simpson, S., Kendig, H., Hirani, V. (2015). Adequacy of nutritional intake among older men living in Sydney, Australia: Findings from the Concord Health and Ageing in Men Project (CHAMP). British Journal of Nutrition, 114(5), 812-821. [More Information]
Scott, I., Le Couteur, D. (2015). Author reply. Internal Medicine Journal, 45(8), 885-886. [More Information]
Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D., Kelly, P., Handelsman, D., Waite, L., Cumming, R. (2015). Cross-Sectional and Longitudinal Associations Between Anemia and Frailty in Older Australian Men: The Concord Health and Aging in Men Project. Journal of the American Medical Directors Association (JAMDA), 16(7), 614-620. [More Information]
Hirani, V., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Waite, L., Handelsman, D., Seibel, M. (2015). Cross-sectional and longitudinal associations between the active vitamin D metabolite (1,25 dihydroxyvitamin D) and haemoglobin levels in older Australian men: the Concord Health and Ageing in Men Project. Age, 37(1), 1-13. [More Information]
Solon-Biet, S., Mitchell, S., Coogan, S., Cogger, V., Gokarn, R., McMahon, A., Raubenheimer, D., De Cabo, R., Simpson, S., Le Couteur, D. (2015). Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice. Cell Reports, 11(10), 1529-1534. [More Information]
Liang, X., Grice, J., Zhu, Y., Liu, D., Sanchez, W., Li, Z., Crawford, D., Le Couteur, D., Cogger, V., Liu, X., et al (2015). Intravital Multiphoton Imaging of the Selective Uptake of Water-Dispersible Quantum Dots into Sinusoidal Liver Cells. Small, 11(14), 1711-1720. [More Information]
Gnjidic, D., Bennett, A., Le Couteur, D., Blyth, F., Cumming, R., Waite, L., Handelsman, D., Naganathan, V., Matthews, S., Hilmer, S. (2015). Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study. International Journal of Cardiology, 192, 49-55. [More Information]
Hsu, B., Cumming, R., Waite, L., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Handelsman, D. (2015). Longitudinal Relationships between Reproductive Hormones and Cognitive Decline in Older Men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 100(6), 2223-2230. [More Information]
Solon-Biet, S., Walters, K., Simanainen, U., McMahon, A., Ruohonen, K., Ballard, J., Raubenheimer, D., Handelsman, D., Le Couteur, D., Simpson, S. (2015). Macronutrient balance, reproductive function, and lifespan in aging mice. Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3481-3486. [More Information]
Solon-Biet, S., Mitchell, S., De Cabo, R., Raubenheimer, D., Le Couteur, D., Simpson, S. (2015). Macronutrients and caloric intake in health and longevity. Journal of Endocrinology, 226(1), R17-R28. [More Information]
Scott, I., Le Couteur, D. (2015). Physicians need to take the lead in deprescribing. Internal Medicine Journal, 45(3), 352-356. [More Information]
Simpson, S., Le Couteur, D., Raubenheimer, D. (2015). Putting the Balance Back in Diet. Cell, 161(1), 18-23. [More Information]
Scott, I., Hilmer, S., Reeve, E., Potter, K., Le Couteur, D., Rigby, D., Gnjidic, D., Del Mar, C., Roughead, E., Page, A., Jansen, J., et al (2015). Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Internal Medicine, 175(5), 827-834. [More Information]
Hsu, B., Cumming, R., Seibel, M., Naganathan, V., Blyth, F., Bleicher, K., Dave, A., Le Couteur, D., Waite, L., Handelsman, D. (2015). Reproductive Hormones and Longitudinal Change in Bone Mineral Density and Incident Fracture Risk in Older Men: The Concord Health and Aging in Men Project. Journal of Bone and Mineral Research, 30(9), 1701-1708. [More Information]
Hirani, V., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2015). Sarcopenia Is Associated With Incident Disability, Institutionalization, and Mortality in Community-Dwelling Older Men: The Concord Health and Ageing in Men Project. Journal of the American Medical Directors Association (JAMDA), 16(7), 607-613. [More Information]
Sierro, F., Tay, S., Warren, A., Le Couteur, D., McCaughan, G., Bowen, D., Bertolino, P. (2015). Suicidal Emperipolesis: A process leading to cell-in-cell structures, T cell clearance and immune homeostasis. Current Molecular Medicine, 15(9), 819-827. [More Information]
De Cabo, R., Le Couteur, D. (2015). The Biology of Aging. In D. Kasper, A. Fauci, S. Hauser, D. Longo, J. Jameson, J. Loscalzo (Eds.), Harrison's Principles of Internal Medicine, (pp. 94e1-94e8). Columbus: McGraw-Hill Education.
Mach, J., Huizer-Pajkos, A., Kane, A., Jones, B., McKenzie, C., Mitchell, S., de Cabo, R., Cogger, V., Le Couteur, D., Hilmer, S. (2015). The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. Experimental Gerontology, 67, 54-61. [More Information]
Le Couteur, D., Tay, S., Solon-Biet, S., Bertolino, P., McMahon, A., Cogger, V., Colakoglu, F., Warren, A., Holmes, A., Pichaud, N., Raubenheimer, D., Simpson, S., et al (2015). The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 70(12), 1499-1507. [More Information]
Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2015). The Longitudinal Relationship of Sexual Function and Androgen Status in Older Men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 100(4), 1350-1358. [More Information]

show 19 more

2014

Scheibye-Knudsen, M., Mitchell, S., Fang, E., Iyama, T., Ward, T., Wang, J., Dunn, C., Singh, N., Veith, S., Hasan-Olive, M., Cogger, V., Warren, A., Le Couteur, D., et al (2014). A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. Cell Metabolism, 20(5), 840-855. [More Information]
Fransen, M., Su, S., Harmer, A., Blyth, F., Naganathan, V., Sambrook, P., Le Couteur, D., Cumming, R. (2014). A longitudinal study of knee pain in older men: Concord Health and Ageing in Men Project. Age and Ageing, 43(2), 206-212. [More Information]
Cogger, V., Mitchell, S., Warren, A., De Cabo, R., Le Couteur, D. (2014). Age-Related Loss of Responsiveness to 2,5-Dimethoxy-4-Iodoamphetamine in Liver Sinusoidal Endothelial Cells. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(5), 514-518. [More Information]
Ilomaki, J., Gnjidic, D., Le Couteur, D., Bell, J., Blyth, F., Handelsman, D., Cumming, R., Seibel, M., Waite, L., Naganathan, V., Hilmer, S. (2014). Alcohol consumption and tobacco smoking among community-dwelling older Australian men: the Concord Health and Ageing in Men Project. Australasian Journal on Ageing, 33(3), 185-192. [More Information]
Le Couteur, D., Simpson, S., De Cabo, R. (2014). Are glycans the holy grail for biomarkers of aging? (Comment on: Glycans Are a Novel Biomarker of Chronological and Biological Age by Kristic et al.). Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(7), 777-778. [More Information]
Kouladjian-O'Donnell, L., Hilmer, S., Chen, T., Le Couteur, D., Gnjidic, D. (2014). Assessing the harms of polypharmacy requires careful interpretation and consistent definitions. British Journal of Clinical Pharmacology, 78(3), 670-671. [More Information]
Hsu, B., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Associations between circulating reproductive hormones and SHBG and prevalent and incident metabolic syndrome in community-dwelling older men: the Concord Health and Ageing in Men Project. The Journal of Clinical Endocrinology and Metabolism, 99(12), E2686-E2691. [More Information]
Hirani, V., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014). Associations Between Serum 25-Hydroxyvitamin D Concentrations and Multiple Health Conditions, Physical Performance Measures, Disability, and All-Cause Mortality: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(3), 417-425. [More Information]
Le Couteur, D., Naganathan, V., Cogger, V., Simpson, S., De Cabo, R. (2014). Biology of ageing. In Gideon Kaplan (Eds.), Geriatric Medicine: An Introduction, (pp. 3-16). Melbourne: IP Communications.
Gnjidic, D., Le Couteur, D., Hilmer, S. (2014). Discontinuing drug treatments. BMJ, 349, g7013. [More Information]
Cogger, V., Svistounov, D., Warren, A., Zykova, S., Melvin, R., Solon-Biet, S., O'Reilly, J., McMahon, A., Ballard, J., De Cabo, R., Le Couteur, D., et al (2014). Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(9), 1076-1086. [More Information]
Hsu, B., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Longitudinal and Cross-Sectional Relationships of Circulating Reproductive Hormone Levels to Self-Rated Health and Health-Related Quality of Life in Community-Dwelling Older Men. The Journal of Clinical Endocrinology and Metabolism, 99(5), 1638-1647. [More Information]
Hsu, B., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Seibel, M., Waite, L., Handelsman, D. (2014). Longitudinal relationships of circulating reproductive hormone with functional disability, muscle mass and strength in community-dwelling older men: The Concord Health and Ageing in Men Project. Journal of Clinical Endocrinology and Metabolism, 99(9), 3310-3318. [More Information]
Hirani, V., Cumming, R., Le Couteur, D., Naganathan, V., Blyth, F., Handelsman, D., Waite, L., Seibel, M. (2014). Low Levels of 25-Hydroxy Vitamin D and Active 1,25-Dihydroxyvitamin D Independently Associated with Type 2 Diabetes Mellitus in Older Australian Men: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 62(9), 1741-1747. [More Information]
Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D., Gnjidic, D., Stanaway, F., Seibel, M., Waite, L., Handelsman, D., Cumming, R. (2014). Multiple, but not traditional risk factors predict mortality in older people: the concord health and ageing in men project. Age, 36(6), 1-15. [More Information]
Gnjidic, D., Blyth, F., Le Couteur, D., Cumming, R., McLachlan, A., Handelsman, D., Seibel, M., Waite, L., Naganathan, V. (2014). Nonsteroidal anti-inflammatory drugs (NSAIDs) in older people: Prescribing patterns according to pain prevalence and adherence to clinical guidelines. Pain, 155(9), 1814-1820. [More Information]
Fairhall, N., Sherrington, C., Cameron, I., Blyth, F., Naganathan, V., Clemson, L., Le Couteur, D., Handelsman, D., Waite, L., Cumming, R. (2014). Predicting participation restriction in community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 43(1), 31-37. [More Information]
Naganathan, V., Le Couteur, D. (2014). Prescribing medications to older people. In Gideon Kaplan (Eds.), Geriatric Medicine: An Introduction, (pp. 258-270). Melbourne: IP Communications.
Gnjidic, D., Le Couteur, D., Hilmer, S., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Bell, J. (2014). Sedative load and functional outcomes in community-dwelling older Australian men: the CHAMP study. Fundamental and Clinical Pharmacology, 28(1), 10-19. [More Information]
Le Couteur, D., Brayne, C. (2014). Should Family Physicians Routinely Screen Patients for Cognitive Impairment? No: Screening Has Been Inappropriately Urged Despite Absence of Evidence. American Family Physician, 89(11), 864-865.
Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
Mach, J., Huizer-Pajkos, A., Cogger, V., McKenzie, C., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2014). The Effect of Aging on Acetaminophen Pharmacokinetics, Toxicity and Nrf2 in Fischer 344 Rats. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(4), 387-397. [More Information]
Le Couteur, D., Wilder, S., De Cabo, R., Simpson, S. (2014). The Evolution of Research on Ageing and Nutrition. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 69(1), 1-2. [More Information]
Solon-Biet, S., McMahon, A., Ballard, J., Ruohonen, K., Wu, L., Cogger, V., Warren, A., Huang, X., Pichaud, N., Melvin, R., Gokam, R., Khalil, M., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2014). The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism, 19(3), 418-430. [More Information]
Bleicher, K., Cumming, R., Naganathan, V., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2014). U-Shaped Association Between Serum 25-Hydroxyvitamin D and Fracture Risk in Older Men: Results from the Prospective Population Based CHAMP Study. Journal of Bone and Mineral Research, 29(9), 2024-2031. [More Information]
Le Couteur, D., Warren, A., Cogger, V., Bertolino, P. (2014). Ultrastructure of the Liver Sinusoid. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 1235-1240). New York: Springer Science+Business Media. [More Information]

show 23 more

2013

Cogger, V., Roessner, U., Warren, A., Fraser, R., Le Couteur, D. (2013). A Sieve-Raft Hypothesis for the regulation of endothelial fenestrations. Computational and Structural Biotechnology Journal, 8(11), 1-9. [More Information]
Hirani, V., Naganathan, V., Cumming, R., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013). Associations Between Frailty and Serum 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Concentrations in Older Australian Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 68(9), 1112-1121. [More Information]
McMahon, A., Parry, S., Benson, V., Witting, P., Le Couteur, D. (2013). Beneficial effects of the synthetic antioxidant tert-butyl bisphenol on the hepatic microcirculation in a rat model of diabetes mellitus. Acta Diabetologica, 50(4), 645-649. [More Information]
Wilder, S., Le Couteur, D., Simpson, S. (2013). Diet mediates the relationship between longevity and reproduction in mammals. Age, 35(3), 921-927. [More Information]
Gnjidic, D., Le Couteur, D., Hilmer, S. (2013). Discontinuation of statins in routine care settings. Annals of Internal Medicine, 159(1), 73-74. [More Information]
Huang, X., Hancock, D., Gosby, A., McMahon, A., Solon-Biet, S., Le Couteur, D., Conigrave, A., Raubenheimer, D., Simpson, S. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage and heat production in mice. Obesity, 21(1), 85-92. [More Information]
Gnjidic, D., Le Couteur, D., Pearson, S., McLachlan, A., Viney, R., Hilmer, S., Blyth, F., Joshy, G., Banks, E. (2013). High risk prescribing in older adults: prevalence, clinical and economic implications and potential for intervention at the population level. BMC Public Health, 13, 1-9. [More Information]
Gnjidic, D., Hilmer, S., Le Couteur, D. (2013). Optimal cutoff of polypharmacy and outcomes - reply. Journal of Clinical Epidemiology, 66(4), 465-466. [More Information]
Le Couteur, D., Doust, J., Creasey, H., Brayne, C. (2013). Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis. BMJ, 347(7925), 1-6. [More Information]
Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2013). Predictors of the rate of BMD loss in older men: findings from the CHAMP study. Osteoporosis International, 24(7), 1951-1963. [More Information]
Ilomaki, J., Gnjidic, D., Hilmer, S., Le Couteur, D., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Blyth, F., Handelsman, D., et al (2013). Psychotropic drug use and alcohol drinking in community-dwelling older Australian men: the CHAMP study. Drug and Alcohol Review, 32(2), 218-222. [More Information]
Horan, M., Rumbley, J., Melvin, R., Le Couteur, D., Ballard, J. (2013). Quaternary protein modeling to predict the function of DNA variation found in human mitochondrial cytochrome c oxidase. Journal of Human Genetics, 58(3), 127-134. [More Information]
Gnjidic, D., Le Couteur, D., Blyth, F., Travison, T., Rogers, K., Naganathan, V., Cumming, R., Waite, L., Seibel, M., Handelsman, D., McLachlan, A., Hilmer, S. (2013). Statin use and clinical outcomes in older men: a prospective population-based study. BMJ Open, 3(3), 1-10. [More Information]
Hirani, V., Cumming, R., Blyth, F., Naganathan, V., Le Couteur, D., Handelsman, D., Waite, L., Seibel, M. (2013). Vitamin D Status Among Older Community Dwelling Men Living In A Sunny Country And Associations With Lifestyle Factors: The Concord Health And Ageing In Men Project, Sydney, Australia. Journal of Nutrition, Health and Aging, 17(7), 587-593. [More Information]

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2012

Le Couteur, D., Robinson, M., Leverton, A., Creasey, H., Waite, L., Atkins, K., McLachlan, A. (2012). Adherence, persistence and continuation with cholinesterase inhibitors in Alzheimer's disease. Australasian Journal on Ageing, 31(3), 164-169. [More Information]
Le Couteur, D., McLachlan, A., Quinn, R., Simpson, S., De Cabo, R. (2012). Aging biology and novel targets for drug discovery. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 67A(2), 168-174. [More Information]
Le Couteur, D., McLachlan, A., De Cabo, R. (2012). Aging, Drugs, and Drug Metabolism. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 67A(2), 137-139. [More Information]
Baur, J., Ungvari, Z., Minor, R., Le Couteur, D., De Cabo, R. (2012). Are sirtuins viable targets for improving healthspan and lifespan? Nature Reviews. Drug Discovery, 11(6), 443-461. [More Information]
Gnjidic, D., Le Couteur, D., Kouladjian, L., Hilmer, S. (2012). Deprescribing trials: methods to reduce polypharmacy and the impact on prescribing and clinical outcomes. Clinics in Geriatric Medicine, 28(2), 237-253. [More Information]
Le Couteur, D., Handelsman, D. (2012). DNA damage, NF-κB and accelerated aging. Asian Journal of Andrology, 14(6), 811-812. [More Information]
Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2012). Drug Burden Index and Beers Criteria: Impact on Functional Outcomes in Older People Living in Self-Care Retirement Villages. The Journal of Clinical Pharmacology, 52(2), 258-265. [More Information]
Gnjidic, D., Le Couteur, D., Naganathan, V., Cumming, R., Creasey, H., Waite, L., Sharma, A., Blyth, F., Hilmer, S. (2012). Effects of drug burden index on cognitive function in older men. Journal of Clinical Psychopharmacology, 32(2), 273-277. [More Information]
Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Cumming, R., Handelsman, D., McLachlan, A., Abernethy, D., Banks, E., Le Couteur, D. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology & Therapeutics, 91(3), 521-528. [More Information]
Gnjidic, D., Hilmer, S., Le Couteur, D. (2012). High-risk prescribing in older people: More harm than good? Aging Health, 8(4), 325-327. [More Information]
Bell, S., Le Couteur, D., McLachlan, A., Chen, T., Moles, R., Basger, B., Hilmer, S. (2012). Improving medicine selection for older people: Do we need an Australian classification for inappropriate medicines use? Australian Family Physician, 41(1/2), 9-10. [More Information]
Svistounov, D., Zykova, S., Cogger, V., Warren, A., McMahon, A., Fraser, R., Le Couteur, D. (2012). Liver Sinusoidal Endothelial Cells and Regulation of Blood Lipoproteins. In Roya Kelishadi (Eds.), Dyslipidemia - From Prevention to Treatment, (pp. 263-278). Croatia: InTech Publishers. [More Information]
Gnjidic, D., Stanaway, F., Cumming, R., Waite, L., Blyth, F., Naganathan, V., Handelsman, D., Le Couteur, D. (2012). Mild Cognitive Impairment Predicts Institutionalization among Older Men: A Population-Based Cohort Study. PloS One, 7(9), 1-8. [More Information]
Gnjidic, D., Le Couteur, D., Hilmer, S. (2012). Off-Label Use of Medicines: Time for Action. Clinical Pharmacology & Therapeutics, 92(2), 157-157. [More Information]
Gnjidic, D., Hilmer, S., Blyth, F., Naganathan, V., Waite, L., Seibel, M., McLachlan, A., Cumming, R., Handelsman, D., Le Couteur, D. (2012). Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989-995. [More Information]
Litchfield, M., Cumming, R., Smith, D., Naganathan, V., Le Couteur, D., Waite, L., Blyth, F., Handelsman, D. (2012). Prostate-specific antigen levels in men aged 70 years and over: Findings from the CHAMP study. Medical Journal of Australia, 196(6), 395-398. [More Information]
Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2012). The Influence of Old Age and Poloxamer-407 on the Hepatic Disposition of Diazepam in the Isolated Perfused Rat Liver. Pharmacology: international journal of experimental and clinical pharmacology, 90(5-6), 233-241. [More Information]
Fraser, R., Cogger, V., Dobbs, B., Jamieson, H., Warren, A., Hilmer, S., Le Couteur, D. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. [More Information]
Svistounov, D., Warren, A., McNerney, G., Owen, D., Zencak, D., Zykova, S., Crane, H., Huser, T., Quinn, R., Smedsrod, B., Le Couteur, D., Cogger, V. (2012). The Relationship between Fenestrations, Sieve Plates and Rafts in Liver Sinusoidal Endothelial Cells. PloS One, 7(9), 1-9. [More Information]
Sorensen, K., McCourt, P., Berg, T., Crossley, C., Le Couteur, D., Wake, K., Smedsrod, B. (2012). The scavenger endothelial cell: a new player in homeostasis and immunity. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 303(12), R1217-R1230. [More Information]
Hilmer, S., Gnjidic, D., Le Couteur, D. (2012). Thinking through the medication list: Appropriate prescribing and deprescribing in robust and frail older patients. Australian Family Physician, 41(12), 924-928. [More Information]

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2011

Le Couteur, D., Simpson, S. (2011). Adaptive Senectitude: The Prolongevity Effects of Aging. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 66A(2), 179-182. [More Information]
Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Jones, B., De Cabo, R., Hilmer, S. (2011). Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 66A(4), 400-408. [More Information]
McMahon, A., Hing, A., Cogger, V., Le Couteur, D. (2011). Animal models of early atherosclerosis: How to translate the data into clinical perspectives. In Petru Liuba (Eds.), Silent Vasculopathy in Childhood: Should Clinicians Care, (pp. 39-63). India: Transworld Research Network.
Stanaway, F., Blyth, F., Cumming, R., Naganathan, V., Handelsman, D., Waite, L., Sambrook, P., Creasey, H., Seibel, M., Le Couteur, D. (2011). Back pain in older male Italian-born immigrants in Australia: The importance of socioeconomic factors. European Journal of Pain, 15(1), 70-76. [More Information]
Travison, T., Nguyen, A., Naganathan, V., Stanaway, F., Blyth, F., Cumming, R., Le Couteur, D., Sambrook, P., Handelsman, D. (2011). Changes in Reproductive Hormone Concentrations Predict the Prevalence and Progression of the Frailty Syndrome in Older Men: The Concord Health and Ageing in Men Project. The Journal of Clinical Endocrinology and Metabolism, 96(8), 2464-2474. [More Information]
McLachlan, A., Bath, S., Naganathan, V., Hilmer, S., Le Couteur, D., Gibson, S., Blyth, F. (2011). Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment. British Journal of Clinical Pharmacology, 71(3), 351-364. [More Information]
Le Couteur, D., Banks, E., Gnjidic, D., McLachlan, A. (2011). Deprescribing. Australian Prescriber, 34(6), 182-185. [More Information]
Le Couteur, D., Benson, V., McMahon, A., Blyth, F., Handelsman, D., Seibel, M., Kennerson, M., Naganathan, V., Cumming, R., De Cabo, R. (2011). Determinants of Serum-Induced SIRT1 Expression in Older Men: The CHAMP Study. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(1), 3-8. [More Information]
Stanaway, F., Cumming, R., Naganathan, V., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M., Sambrook, P. (2011). Ethnicity and falls in older men: low rate of falls in Italian-born men in Australia. Age and Ageing, 40, 595-601. [More Information]
Le Couteur, D., Cogger, V., Dobbs, B., Fraser, R. (2011). Fenestrations and lipoproteins. Cardiovascular Pathology, 20(3), 191-193. [More Information]
Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16735-16740. [More Information]
Stanaway, F., Gnjidic, D., Blyth, F., Le Couteur, D., Naganathan, V., Waite, L., Seibel, M., Handelsman, D., Sambrook, P., Cumming, R. (2011). How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over. BMJ: British Medical Journal, 343, d7679-1-d7679-4. [More Information]
Blyth, F., Cumming, R., Nicholas, M., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2011). Intrusive Pain and Worry about Health in Older Men: The CHAMP Study. Pain, 152(2), 447-452. [More Information]
Mitchell, S., Huizer-Pajkos, A., Cogger, V., McLachlan, A., Le Couteur, D., Hilmer, S. (2011). Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver. Journal of Pharmaceutical Sciences, 100(1), 334-340. [More Information]
Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2011). Reducing drugs in older adults is more. Archives of Internal Medicine, 171(9), 868-869. [More Information]
LabbÃ©, A., Garand, C., Cogger, V., Paquet, E., Desbiens, M., Le Couteur, D., Lebel, M. (2011). Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 66A(312492), 264-278. [More Information]
Nabipour, I., Sambrook, P., Blyth, F., Janu, M., Waite, L., Naganathan, V., Handelsman, D., Le Couteur, D., Cumming, R., Seibel, M. (2011). Serum Uric Acid Is Associated With Bone Health in Older Men: A Cross-Sectional Population-Based Study. Journal of Bone and Mineral Research, 26(5), 955-964. [More Information]
Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2011). Socioeconomic status and bone health in community-dwelling older men: The CHAMP Study. Osteoporosis International, 22(5), 1343-1353. [More Information]
Everitt, A., Le Couteur, D., Kendig, H. (2011). The Changing Face of Ageing Research and Practice in Australia over the last 50 years. Australasian Journal on Ageing, 30(4), 173-174. [More Information]
Warren, A., Cogger, V., Fraser, R., DeLeve, L., McCuskey, R., Le Couteur, D. (2011). The Effects of Old Age on Hepatic Stellate Cells. Current Gerontology and Geriatrics Research, 2011, 1-7. [More Information]
Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]
Bleicher, K., Cumming, R., Naganathan, V., Travison, T., Sambrook, P., Blyth, F., Handelsman, D., Le Couteur, D., Waite, L., Creasey, H., Seibel, M. (2011). The role of fat and lean mass in bone loss in older men: Findings from the CHAMP study. Bone, 49(6), 1299-1305. [More Information]

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2010

Le Couteur, D., Sinclair, D. (2010). A Blueprint for Developing Therapeutic Approaches That Increase Healthspan and Delay Death. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(7), 693-4. [More Information]
Gnjidic, D., Le Couteur, D., Abernethy, D., Hilmer, S. (2010). A Pilot Randomized Clinical Trial Utilizing the Drug Burden Index to Reduce Exposure to Anticholinergic and Sedative Medications in Older People. The Annals of Pharmacotherapy, 44(11), 1725-1732. [More Information]
Le Couteur, D., Lakatta, E. (2010). A Vascular Theory of Aging. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(10), 1025-7. [More Information]
Simon-Santamaria, J., Malovic, I., Warren, A., Oteiza, A., Le Couteur, D., Smedsrod, B., McCourt, P., Sorensen, K. (2010). Age-Related Changes in Scavenger Receptor-Mediated Endocytosis in Rat Liver Sinusoidal Endothelial Cells. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(9), 951-960. [More Information]
Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
Everitt, A., Heilbronn, L., Morris, B., Brown-Borg, H., Merry, B., Simpson, S., Varady, K., Masoro, E., Redman, L., Le Couteur, D. (2010). Conclusion: Human Calorie Restriction and Anti-Aging Therapy. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 311-318). Dordrecht: Springer. [More Information]
McLachlan, A., Hilmer, S., Le Couteur, D. (2010). Dosing Errors: Age-Related Changes in Pharmacokinetics. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 127-135). New York: Springer Science+Business Media. [More Information]
Mitchell, S., Kirkpatrick, C., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Blyth, F., Waite, L., Handelsman, D., Cumming, R., Hilmer, S. (2010). Estimation of lean body weight in older community-dwelling men. British Journal of Clinical Pharmacology, 69(2), 118-127. [More Information]
Le Couteur, D., Ford, G., McLachlan, A. (2010). Evidence, Ethics and Medication Management in Older People. Journal of Pharmacy Practice and Research, 40(2), 148-152.
Everitt, A., Heilbronn, L., Le Couteur, D. (2010). Food Intake, Life Style, Aging and Human Longevity. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 15-41). Dordrecht: Springer. [More Information]
Everitt, A., Brown-Borg, H., Le Couteur, D., Bartke, A. (2010). Food Restriction, Hormones, Genes and Aging. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 217-318). Dordrecht: Springer. [More Information]
Rochat, S., Cumming, R., Blyth, F., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2010). Frailty and use of health and community services by community-dwelling older men: the Concord Health and Ageing in Men Project. Age and Ageing, 39(2), 228-233. [More Information]
Bleicher, K., Cumming, R., Naganathan, V., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Creasey, H., Waite, L. (2010). Lifestyle factors, medications, and disease influence bone mineral density in older men: findings from the CHAMP study. Osteoporosis International, 22(9), 1-17. [More Information]
Warren, A., Cogger, V., Arias, I., McCuskey, R., Le Couteur, D. (2010). Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice. Microcirculation, 17(1), 32-38. [More Information]
Hairi, N., Cumming, R., Naganathan, V., Handelsman, D., Le Couteur, D., Creasey, H., Waite, L., Seibel, M., Sambrook, P. (2010). Loss of Muscle Strength, Mass (Sarcopenia), and Quality (Specific Force) and Its Relationship with Functional Limitation and Physical Disability: The Concord Health and Ageing in Men Project. Journal of the American Geriatrics Society, 58(11), 2055-2062. [More Information]
Pallardo, F., Lloret, A., Lebel, M., dâ€™Ischia, M., Cogger, V., Le Couteur, D., Gadaleta, M., Castello, G., Pagano, G. (2010). Mitochondrial dysfunction in some oxidative stress-related genetic diseases: Ataxia-Telangiectasia, Down Syndrome, Fanconi Anaemia and Werner Syndrome. Biogerontology, 11(4), 401-419. [More Information]
Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2010). Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. International Journal of Infectious Diseases, 14(10), e857-e867. [More Information]
Bleicher, K., Naganathan, V., Cumming, R., Seibel, M., Sambrook, P., Blyth, F., Le Couteur, D., Handelsman, D., Waite, L., Creasey, H. (2010). Prevalence and treatment of osteoporosis in older Australian men: findings from the CHAMP study. Medical Journal of Australia, 193(7), 387-391. [More Information]
Le Couteur, D. (2010). Red yeast rice for dyslipidemia in statin-intolerant patients. Annals of Internal Medicine, 152(2), 134-135. [More Information]
Nabipour, I., Cumming, R., Handelsman, D., Litchfield, M., Naganathan, V., Waite, L., Creasey, H., Janu, M., Le Couteur, D., Sambrook, P., Seibel, M. (2010). Socioeconomic status and bone health in community-dwelling older men: the CHAMP Study. Osteoporosis International, 22(5), 1343-1353. [More Information]
Le Couteur, D., Sinclair, D., Cogger, V., McMahon, A., Warren, A., Everitt, A., Lebel, M., De Cabo, R. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In Everitt, A.V., Rattan, S.I.S., Le Couteur, D.G. and de Cabo, R. (Eds.), Calorie Restriction, Aging and Longevity, (pp. 191-216). Dordrecht: Springer. [More Information]
Le Couteur, D., Blyth, F., Creasey, H., Handelsman, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L., Cumming, R. (2010). The Association of Alanine Transaminase With Aging, Frailty, and Mortality. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 65(7), 712-717. [More Information]
Sabaretnam, T., Kritharides, L., O'Reilly, J., Le Couteur, D. (2010). The effect of aging on the response of isolated hepatocytes to hydrogen peroxide and tert-butyl hydroperoxide. Toxicology in Vitro, 24(1), 123-128. [More Information]
O'Reilly, J., Cogger, V., Fraser, R., Le Couteur, D. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. [More Information]
Sabaretnam, T., O'Reilly, J., Kritharides, L., Le Couteur, D. (2010). The effect of old age on apolipoprotein E and its receptors in rat liver. Age, 32(1), 69-77. [More Information]
Le Couteur, D., Kendig, H., Naganathan, V., McLachlan, A. (2010). The Ethics of Prescribing Medications to Older People. In Susan Koch, F. Michael Gloth, and Rhonda Nay (Eds.), Medication Management in Older Adults: A Concise Guide for Clinicians, (pp. 29-42). New York: Springer Science+Business Media. [More Information]
Cogger, V., McNerney, G., Nyunt, T., DeLeve, L., McCourt, P., Smedsrod, B., Le Couteur, D., Huser, T. (2010). Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. Journal of Structural Biology, 171(3), 382-388. [More Information]
Kwong, P., Cumming, R., Chan, L., Seibel, M., Naganathan, V., Creasey, H., Le Couteur, D., Waite, L., Sambrook, P., Handelsman, D. (2010). Urinary incontinence and quality of life among older community-dwelling Australian men: the CHAMP study. Age and Ageing, 39(3), 349-354. [More Information]
Massip, L., Garand, C., Paquet, E., Cogger, V., O'Reilly, J., Tworek, L., Hatherall, A., Taylor, C., Thorin, E., Zahradka, P., Le Couteur, D., et al (2010). Vitamin C restores healthy aging in a mouse model for Werner syndrome. The FASEB Journal, 24(1), 158-172. [More Information]

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2009

Hilmer, S., Seale, J., Le Couteur, D., Crampton, R., Liddle, C. (2009). Do medical courses adequately prepare interns for safe and effective prescribing in New South Wales public hospitals? Internal Medicine Journal, 39(7), 428-434. [More Information]
Gnjidic, D., Cumming, R., Le Couteur, D., Handelsman, D., Naganathan, V., Abernethy, D., Hilmer, S. (2009). Drug Burden Index and physical function in older Australian men. British Journal of Clinical Pharmacology, 68(1), 97-105. [More Information]
Sabaretnam, T., Harris, M., Kockx, M., Witting, P., Le Couteur, D., Kritharides, L. (2009). Effects of hydrogen peroxide and apolipoprotein e isoforms on apolipoprotein e trafficking in HepG2 cells. Clinical and Experimental Pharmacology and Physiology, 36(12), e96-e102. [More Information]
Smedsrd, B., Le Couteur, D., Ikejima, K., Kawada, N., Naito, M., Knolle, P., Nagy, L., Senoo, H., Vidal-Vanaclocha, F., Yamaguchi, N., et al (2009). Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium. Liver International, 29(4), 490-501. [More Information]
O'Reilly, J., Cogger, V., Le Couteur, D. (2009). Old age is associated with ultrastructural changes in isolated rat liver sinusoidal endothelial cells. Journal of Electron Microscopy, 59(1), 65-69. [More Information]
Cheluvappa, R., Denning, G., Lau, G., Grimm, M., Hilmer, S., Le Couteur, D. (2009). Pseudomonas aeruginosa and the hyperlipidaemia of sepsis. Pathology, 41(7), 615-621. [More Information]
Le Couteur, D., Everitt, A., Lebel, M. (2009). The aging liver. Geriatrics and Ageing, 12(6), 319-322.
McLachlan, A., Hilmer, S., Le Couteur, D. (2009). Variability in response to medicines in older people: Phenotypic and genotypic factors. Clinical Pharmacology & Therapeutics, 85(4), 431-433. [More Information]

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2008

Cumming, R., Handelsman, D., Seibel, M., Creasey, H., Sambrook, P., Waite, L., Naganathan, V., Le Couteur, D., Litchfield, M. (2008). Cohort profile: The Concord Health and Ageing in Men Project (CHAMP). International Journal of Epidemiology, 38(2), 374-378. [More Information]
Warren, A., Chaberek, S., Ostrowski, K., Cogger, V., Hilmer, S., McCuskey, R., Fraser, R., Le Couteur, D. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. [More Information]
Cheluvappa, R., Cogger, V., Kwun, S., O'Reilly, J., Le Couteur, D., Hilmer, S. (2008). Liver sinusoidal endothelial cells and acute non-oxidative hepatic injury induced by Pseudomonas aeruginosa pyocyanin. International Journal of Experimental Pathology: mechanisms and models of disease, 89(6), 410-418. [More Information]
Iyer, S., Naganathan, V., McLachlan, A., Le Couteur, D. (2008). Medication Withdrawal Trials in People Aged 65 Years and Older: A Systematic Review. Drugs and Aging, 25(12), 1021-1031. [More Information]
Le Couteur, D., Warren, A., Cogger, V., Smedsrod, B., Sorensen, K., De Cabo, R., Fraser, R., McCuskey, R. (2008). Old age and the hepatic sinusoid. The Anatomical Record, 291(6), 672-683. [More Information]
Blyth, F., Rochat, S., Cumming, R., Creasey, H., Handelsman, D., Le Couteur, D., Naganathan, V., Sambrook, P., Seibel, M., Waite, L. (2008). Pain, frailty and comorbidity on older men: The CHAMP study. Pain, 140(1), 224-230. [More Information]
Le Couteur, D., Kendig, H. (2008). Pharmaco-epistemology for the prescribing geriatrician. Australasian Journal on Ageing, 27(1), 3-7. [More Information]
Cheluvappa, R., Shimmon, R., Dawson, M., Hilmer, S., Le Couteur, D. (2008). Reactions of Pseudomonas aeruginosa pyocyanin with reduced glutathione. Acta Biochimica Polonica, 55(3), 571-580. [More Information]
Pearson, K., Baur, J., Lewis, K., Peshkin, L., Price, N., Labinskyy, N., Swindell, W., Kamara, D., Minor, R., et al, Le Couteur, D., Jamieson, H. (2008). Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism, 8(2), 157-168. [More Information]
Martinez, I., Nedredal, G., Oie, C., Warren, A., Johansen, O., Le Couteur, D., Smedsrod, B. (2008). The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells. Comparative Hepatology, 7(4), 1-11. [More Information]
Cogger, V., Arias, I., Warren, A., McMahon, A., Kiss, D., Avery, V., Le Couteur, D. (2008). The response of fenestrations, actin and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells (a liver endothelial cell line). American Journal of Physiology: Gastrointestinal and Liver Physiology, 295(1), G137-G145. [More Information]

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2007

Le Couteur, D., Cogger, V., McCuskey, R., De Cabo, R., Smedsrod, B., Sorensen, K., Warren, A., Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. Annals of the New York Academy of Sciences, 1114, 79-87. [More Information]
Jamieson, H., Cogger, V., Twigg, S., McLennan, S., Warren, A., Cheluvappa, R., Hilmer, S., Fraser, R., Le Couteur, D. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50(9), 1969-1976. [More Information]
Hilmer, S., Cogger, V., Le Couteur, D. (2007). Basal activity of Kupffer cells increases with old age. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62(9), 973-978. [More Information]
Jamieson, H., Hilmer, S., Cogger, V., Warren, A., Cheluvappa, R., Abernethy, D., Everitt, A., Fraser, R., De Cabo, R., Le Couteur, D. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. [More Information]
Hilmer, S., McLachlan, A., Le Couteur, D. (2007). Clinical pharmacology in the geriatric patient. Fundamental and Clinical Pharmacology, 21(3), 217-230. [More Information]
Cheluvappa, R., Hilmer, S., Kwun, S., Cogger, V., Le Couteur, D. (2007). Effects of old age on hepatocyte oxygenation. Annals of the New York Academy of Sciences, 1114, 88-92. [More Information]
Everitt, A., Le Couteur, D. (2007). Life Extension by Calorie Restriction in Humans. Annals of the New York Academy of Sciences, 1114, 428-433. [More Information]
Latimer Hill, E., Cumming, R., Lewis, R., Carrington, S., Le Couteur, D. (2007). Sleep disturbances and falls in older people. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 62A(1), 62-66. [More Information]
Cheluvappa, R., Hilmer, S., Kwun, S., Jamieson, H., O'Reilly, J., Muller, M., Cogger, V., Le Couteur, D. (2007). The effect of old age on liver oxygenation and the hepatic expression of VEGF and VEGFR2. Experimental Gerontology, 42(10), 1012-1019. [More Information]
Cheluvappa, R., Jamieson, H., Muller, M., Le Couteur, D. (2007). The effect of Pseudomonas aeruginosa virulence factor, pyocyanin, on the liver sinusoidal endothelial cell. Journal of Gastroenterology and Hepatology, 22(8), 1350-1351. [More Information]
Fisher, A., Davis, M., Rubenach, S., Le Couteur, D., McLean, A. (2007). The site-specific epidemiology of hip fracture in the Australian Capital Territory with projections for the first half of the 21st century: Implications for clinical management and health services planning. Australasian Journal on Ageing, 26(1), 45-51. [More Information]

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2006

Le Couteur, D., Cogger, V., Hilmer, S., Muller, M., Harris, M., Sullivan, D., McLean, A., Fraser, R. (2006). Aging, atheroscleroisis and the liver sieve. In Clarke, Leon V (Eds.), New research on atherosclerosis, (pp. 19-44). New York: Nova Science Publishers.
Le Couteur, D., Bailey, L., Naganathan, V. (2006). Beta-blockers and heart failure in older people. European Heart Journal, 27(7), 887-8; author reply 888-9. [More Information]
Everitt, A., Hilmer, S., Brand-Miller, J., Jamieson, H., Truswell, A., Sharma, A., Mason, R., Morris, B., Le Couteur, D. (2006). Dietary approaches that delay age-related diseases. Clinical Interventions in Aging, 1(1), 11-31. [More Information]
Cogger, V., Hilmer, S., Sullivan, D., Muller, M., Fraser, R., Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281. [More Information]
Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
Le Couteur, D., Naganathan, V., Cogger, V., Cumming, R., McLean, A. (2006). Pharmacotherapy in the elderly: clinical issues and perspectives. In Kohli K, Gupta M, Tejwani S. (Eds.), In Contemporary Perspectives on Clinical Pharmacotherapeutics, (pp. 709-722). New Dehli: Elsevier.
Baur, J., Pearson, K., Price, N., Jamieson, H., Lerin, C., Kalra, A., Prabhu, V., Allard, J., Lopez-Lluch, G., Lewis, K., Le Couteur, D., et al (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444(7117), 337-342. [More Information]
Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]

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2005

Cooper, G., Le Couteur, D., Richardson, D., Buckley, N. (2005). A randomized clinical trial of activated charcoal for the routine management of oral drug overdose. QJM, 98(9), 655-660. [More Information]
Hilmer, S., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42(6), 1349-1354. [More Information]
Hien, L., Cumming, R., Cameron, I., Chen, J., Lord, S., March, L., Schwarz, J., Le Couteur, D., Sambrook, P. (2005). Atypical antipsychotic medications and risk of falls in residents of aged care facilities. Journal of the American Geriatrics Society, 53(8), 1290-1295. [More Information]
Everitt, A., Roth, G., Le Couteur, D., Hilmer, S. (2005). Calorie restriction versus drug therapy to delay the onset of ageing diseases and extend life. Age, 27(1), 39-48. [More Information]
Park, G., Katelaris, P., Jones, D., Ngu, M., Le Couteur, D. (2005). Caution before embracing serum markers of liver fibrosis in clinical practice. Gastroenterology, 128(4), 1145-1146. [More Information]
Hilmer, S., Shenfield, G., Le Couteur, D. (2005). Clinical Implications of Changes in Hepatic Drug Metabolism in Older People. Therapeutics and Clinical Risk Management, 1(2), 151-156.
Graffen, M., Saligari, M., Le Couteur, D., Naganathan, V., McLean, A. (2005). Development of a mentorship programme for rural general practitioners by visiting specialist physicians. Rural and Remote Health, 5(2), 374-374. [More Information]
Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
Harris, M., Le Couteur, D., Arias, I. (2005). Progressive familial intrahepatic cholestasis: genetic disorders of biliary transporters. Journal of Gastroenterology and Hepatology, 20(6), 807-17. [More Information]
Katelaris, P., Jones, B., Lin, B., Le Couteur, D., Ngu, M., Park, G., Seow, F. (2005). The 13C-caffeine breath test distinguishes significant fibrosis in chronic hepatitis B and reflects response to lamivudine therapy. Alimentary Pharmacology and Therapeutics, 22(5), 395-403. [More Information]
Fisher, A., Davis, M., Le Couteur, D. (2005). The effect of meals at different mealtimes on blood pressure and symptoms in geriatric patients with postprandial hypotension. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 60(2), 184-5; author reply 185-6. [More Information]
Fisher, A., Davis, M., McLean, A., Le Couteur, D. (2005). The Epidemiology of falls in semi independent residents in residential care. Australasian Journal on Ageing, 24(2), 98-102.
Le Couteur, D., Fraser, R., Hilmer, S., Rivory, L., McLean, A. (2005). The hepatic sinusoid in aging and cirrhosis: effects on hepatic substrate disposition and drug clearance. Clinical Pharmacokinetics, 44(2), 187-200. [More Information]
Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.

show 11 more

2004

McLean, A., Le Couteur, D. (2004). Aging Biology And Geriatric Clinical Pharmacology. Pharmacological Reviews, 56(2), 163-184. [More Information]
Whitbread, A., Mellick, G., Silburn, P., Le Couteur, D., Board, P. (2004). Glutathione Transferase Omega Class Polymorphisms In Parkinson Disease. Neurology, 62(10), 1910-1911. [More Information]
Cogger, V., Warren, A., Fraser, R., Ngu, M., McLean, A., Le Couteur, D. (2004). Preliminary Analysis Of The Sinusoidal Endothelium And Space Of Disse In Ageing Papio Hamadrayas. Comparative Hepatology, 3(Suppl 1), S26-S27.
Cumming, R., Glasgow, N., Le Couteur, D., Naganathan, V., Hilmer, S. (2004). Prescribing In Older People. Australian Family Physician, 33(10), 777-781.
Hilmer, S., Warren, A., Cogger, V., Fraser, R., McLean, A., Sullivan, D., Le Couteur, D. (2004). The Effect Of Aging On The Immunohistochemistry Of Apolipoprotein E In The Liver. Experimental Gerontology, 39(1), 53-57. [More Information]
Cogger, V., Muller, M., Fraser, R., McLean, A., Khan, J., Le Couteur, D. (2004). The Effects Of Oxidative Stress On The Liver Sieve. Journal of Hepatology, 41(3), 370-376. [More Information]
Hilmer, S., Cogger, V., Muller, M., Le Couteur, D. (2004). The Hepatic Pharmacokinetics Of Doxorubicin And Liposomal Doxorubicin. Drug Metabolism and Disposition, 32(8), 794-799. [More Information]
Sullivan, D., Celermajer, D., Le Couteur, D., Lam, C. (2004). The Vascular Implications Of Postprandial Lipoprotein Metabolism. Clinical Biochemist Reviews, 25(1), 19-30.
Le Couteur, D., Yin, Z., McLean, A., Rivory, L. (2004). Wash-In Methodology And Modeling To Determine Hepatocellular D-Glucose Transport In The Perfused Rat Liver. Japanese journal of physiology, 54(4), 421-429. [More Information]

show 6 more

2003

Fisher, A., McLean, A., Davis, M., Le Couteur, D. (2003). A multi-center, case control study of the effects of antihypertensive therapy on orthostatic hypotension, postprandial hypotension and falls in octo-and nonagenarians in residential care facilities. Current Therapeutic Research: Clinical and Experimental, 64(3), 206-214. [More Information]
McLean, A., Cogger, V., Chong, G., Warren, A., Markus, A., Dahlstrom, J., Le Couteur, D. (2003). Age-related pseudocapillarization of the human liver. Journal of Pathology, 200(1), 112-117. [More Information]
Braet, F., Muller, M., Vekemans, K., Wisse, E., Le Couteur, D. (2003). Antimycin A-induced defenestration in rat hepatic sinusoidal endothelial cells. Hepatology, 38(2), 394-402. [More Information]
Cumming, R., Le Couteur, D. (2003). Benzodiazepines and risk of hip fractures in older people: a review of the evidence. CNS Drugs, 17(11), 825-837. [More Information]
Sangalli, M., McLean, A., Peek, M., Rivory, L., Le Couteur, D. (2003). Carbon monoxide disposition and permeability-surface area product in the foetal circulation of the perfused term human placenta. Placenta, 24(1), 8-11. [More Information]
Cogger, V., Warren, A., Fraser, R., Ngu, M., Le Couteur, D., McLean, A. (2003). Hepatic sinusoidal pseudocappilarization with aging in the non-human primate. Experimental Gerontology, 38(10), 1101-1107. [More Information]
Le Couteur, D., Fisher, A., Davis, M., McLean, A. (2003). Postprandial systolic blood pressure responses of older people in residential care: association with risk of falling. Gerontology, 49(4), 260-264. [More Information]
Park, G., Katelaris, P., Jones, D., Seow, F., Le Couteur, D., Ngu, M. (2003). Validity of the 13C-caffeine breath test as a noninvasive, quantitative test of liver function. Hepatology, 38(5), 1227-1236. [More Information]
Hilmer, S., Naganathan, V., Le Couteur, D. (2003). Why do physicians choose to train in geriatric medicine? Australasian Journal on Ageing, 11(3), 160-162.

show 6 more

2002

Croft-Baker, J., Croft-Baker, L., Le Couteur, D., McLean, A. (2002). Age related factors determining safe prescribing for older people. C M E Journal: Geriatric Medicine (CME Geriatric Medicine), 4(1), 4-8.
Le Couteur, D., Muller, M., Yang,, M., Mellick, G., McLean, A. (2002). Age-environment and gene-environment interactions in the pathogenesis of Parkinson's disease. Reviews on Environmental Health, 17(1), 51-64.
Yang, M., Mclean, A., Le Couteur, D. (2002). Age-related alteration in hepatic disposition of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and pesticides. Pharmacology and Toxicology, 90(4), 203-207. [More Information]
Andrews, G., Khalil, Z., Le Couteur, D. (2002). Aging research worldwide: Experimental gerontological research in Australia. Experimental Gerontology, 37(12), 1301-1308.
Shenfield, G., Le Couteur, D., Rivory, L. (2002). Clinical pharmacology. Medical Journal of Australia, , 9-9.
Harvey, P., Gready, J., Yin, Z., Le Couteur, D., Mclean, A. (2002). Hepatic phospholipid changes induced by sustained oxygen supplementation. Pharmacology and Toxicology, 91(3), 150-152. [More Information]
Le Couteur, D., Fraser, R., Cogger, V., McLean, A. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. The Lancet, 359(9317), 1612-1615. [More Information]
Buchanan, D., Silburn, P., Chalk, J., Le Couteur, D., Mellick, G. (2002). The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients. Neuroscience Letters, 327(2), 91-94. [More Information]

show 5 more

2001

Cho, S., McLean, A., Rivory, L., Gatenby, P., Le Couteur, D., Hardman,, D. (2001). Carbon monoxide wash-in method to determine gas transfer in vascular beds: application to rat hindlimb. American Journal of Physiology - Heart and Circulatory Physiology, 280.
Cogger, V., Markus, A., Harvey, P., Ansselin, A., McLean, A., Le Couteur, D., Yin,, Z. (2001). Pseudocapillarization and associated energy limitation in the aged rat liver. Hepatology, 33, 537-543. [More Information]
Cogger, V., Ansselin, A., Le Couteur, D., McLean, A., Mross, P., Hosie, M. (2001). The effect of acute oxidative stress on the ultrastructure of the perfused rat liver. Pharmacology and Toxicology, 89, 306-311. [More Information]

2000

Harvey, P., Gready, J., Yin, Z., Le Couteur, D., McLean, A. (2000). Acute Oxygen Supplementation Restores Markers of Hepatocyte Energy Status and Hypoxia in Cirrhotic Rats. Journal of Pharmacology and Experimental Therapeutics, 293(2), 641-645.
Yang, M., McLean, A., Rivory, L., Le Couteur, D. (2000). Hepatic Disposition of Neurotoxins and Pesticides. Pharmacology and Toxicology, 87(6), 286-291.

Selected Grants

2021

Pack in a pill in a PACA: PACA nanomedicines for targeting age-related change in liver endothelium to prevent age-related diseases, Cogger V, McCourt P, Dietrichs E, Le Couteur D, Hunt N, Ravna A, Sorensen K, Snipstad S, Aslund A, van Grunsven L, Research Council of Norway/Research Support

2019

Self-selected diet composition, adherence to caloric restriction and cardiometabolic disease risk, Le Couteur D, Senior A, National Institutes of Health (USA)/Research Support

2018

Nutrition and Complexity, George J, Simpson S, Le Couteur D, Gunton J, Raubenheimer D, Durrant-Whyte H, National Health and Medical Research Council (NHMRC)/Program Grants
A life-course approach to the nutrition-lifespan-reproduction nexus, Raubenheimer D, Solon-Biet S, Walters K, Le Couteur D, Australian Research Council (ARC)/Discovery Projects (DP)

2017

A targeted approach to age related disease: nanomedicines and the liver sinusoidal endothelium, Cogger V, Le Couteur D, Kuncic Z, McCourt P, National Health and Medical Research Council (NHMRC)/Project Grants

2016

Determining the macronutrient composition of the optimum diet for the management of type 2 diabetes, Wali J, Simpson S, Le Couteur D, Cogger V, Diabetes Australia/Research Grant
Is FGF21 the master regulator of protein intake?, Simpson S, James D, Raubenheimer D, Conigrave A, Le Couteur D, Australian Research Council (ARC)/Discovery Projects (DP)
Molecular pathways linking nutrition and age-related health, Simpson S, Le Couteur D, Cogger V, James D, National Health and Medical Research Council (NHMRC)/Project Grants

2015

The contribution of serum drug concentrations to adverse geriatric outcomes with polypharmacy and increasing drug burden index in a mouse model, Mach J, Hilmer S, Le Couteur D, Australian Association of Gerontology/RM Gibson Research Grants
Touchscreen Operant Chambers for Mice, Johnstone D, Le Couteur D, Cogger V, Burton T, University of Sydney/Equipment Grant

2014

Ageing and latelife health: calories, macronutrients or branched chain amino acids, Simpson S, Le Couteur D, Sinclair D, De Cabo R, National Health and Medical Research Council (NHMRC)/Project Grants
Nutrition, ageing and health, Le Couteur D, DVC Research/HMR+ Implementation Fund - MRI

2013

Health and lifespan regulation by NAD+ and SIRT2, Turner N, Sinclair D, Le Couteur D, National Health and Medical Research Council (NHMRC)/Project Grants
EVOS FL Auto cell imaging system, Allan C, Clark G, Cogger V, Cooper M, Fromm P, Handelsman D, Hart D, Jessup W, Kennerson M, Kockx M, Kritharides L, Le Couteur D, McLachlan A, McMahon A, Nicholson G, Seibel M, Silveira P, Simanainen U, Verma N, Walters K, Zheng Y, Zhou H, National Health and Medical Research Council (NHMRC)/Equipment Grant
Fenestrations and insulin, Le Couteur D, DVC Research/Bridging Support Grant
Centre of Research Excellence in Medicines and Ageing, McLachlan A, Pearson S, Banks E, Preen D, Le Couteur D, Dobbins T, Etherton-Beer C, Buckley N, Viney R, Henry D, National Health and Medical Research Council (NHMRC)/Centres of Research Excellence

2012

Insights from ageing and calorie restriction for the prevention and treatment of paracetamol hepatotoxicity, Hilmer S, Kane A, Le Couteur D, Cogger V, Australian Association of Gerontology/RM Gibson Research Grants
IVIS Lumina II in vivo Imaging System, Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Brennan-Speranza T, Zheng Y, DVC Research/Equipment Grant
Patterns of care and health outcomes: Opportunities for epidemiology and health services research using whole of population, cross-jurisdictional linkage of routinely collected data, Aranda S, Buckley N, Currow D, McLachlan A, Pearson S, Young J, Armstrong B, O'Connell D, Pearson S, Le Couteur D, Buckley N, National Health and Medical Research Council (NHMRC)/Equipment Grant
Automacs Pro Seperator, Hart D, Handelsman D, Le Couteur D, Nicholson G, Kritharides L, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, Simanainen U, Zheng Y, Seibel M, DVC Research/Equipment Grant

2011

High risk prescribing in older Australians, Banks E, Le Couteur D, Pearson S, McLachlan A, Viney R, Hilmer S, Gnjidic D, Blyth F, National Health and Medical Research Council (NHMRC)/Project Grants
High risk prescribing in older Australians, Le Couteur D, National Health and Medical Research Council (NHMRC)/Project Grants

2010

MOLECULAR IMAGER CHEMIDoc XRS SYSTEM & MINI P ROTEAN GEL/TRANSBLOT Cell SYSTEM (BIO-RAD. AUSTRALIA, Allan C, Handelsman D, Zhou H, Seibel M, Kennerson M, Nicholson G, Blair I, Le Couteur D, McMahon A, Hart D, Clark G, Simanainen U, National Health and Medical Research Council (NHMRC)/Equipment Grant

2009

The Lunar PIXImus II DEXA Scanner, Zhou H, Seibel M, Handelsman D, Le Couteur D, Nicholson G, Clarke S, Robertson G, van Zandwijk N, Freedman B, Kennerson M, Allan C, Walters K, Cogger V, Blair I, Reid G, Simanainen U, National Health and Medical Research Council (NHMRC)/Equipment Grant
Ageing, Nutrition and Geometric Framework, Cumming R, Simpson S, Le Couteur D, Blyth F, Naganathan V, Kendig H, Seibel M, National Health and Medical Research Council (NHMRC)/Project Grants

2008

Ageing, Werner syndrome and Pseudocapillarization, Le Couteur D, Cogger V, Lebel M, Quinn R, Hilmer S, McCuskey R, National Health and Medical Research Council (NHMRC)/Project Grants
Stereomicroscope-Imaging Workstation, Allan C, Seibel M, Handelsman D, Le Couteur D, Kennerson M, Robertson G, Walters K, Cogger V, Nicholson G, Zhou H, Blair I, Simanainen U, McMahon A, National Health and Medical Research Council (NHMRC)/Equipment Grant
Optimising pain management in frail older people, McLachlan A, Naganathan V, Le Couteur D, Hilmer S, Gibson S, National Health and Medical Research Council (NHMRC)/Project Grants
The Nutritional geometry of ageing in a rodent model, Simpson S, Le Couteur D, Raubenheimer D, Ballard J, National Health and Medical Research Council (NHMRC)/Project Grants

2007

Sirtuins and the molecular epidemiology of frailty in older men, Cumming R, De Cabo R, Le Couteur D, Kennerson M, De Cabo R, Naganathan V, Sambrook P, National Health and Medical Research Council (NHMRC)/Project Grants

2006

Caloric restriction, ageing and the liver sinusoidal endothelium: mechanisms and implications, De Cabo R, Le Couteur D, De Cabo R, Cogger V, Hilmer S, Frazer R, National Health and Medical Research Council (NHMRC)/Project Grants

2005

Cell culture quarantine and storage facility plus assessories, Dunstan C, Witting P, Myers S, Handelsman D, Seibel M, Nicholson G, Zhou H, Kennerson M, Allan C, Freedman B, Le Couteur D, Muller M, National Health and Medical Research Council (NHMRC)/Equipment Grant
KODAK Image Station 2000mm Multi-Modal Imager, Blair J, Dunstan C, Freedman B, Kennerson M, Le Couteur D, Muller M, Myers S, Nicholson G, Seibel M, Witting P, University of Sydney/Major Equipment Grant

2004

How is lipoprotein disposition influenced by fenestrae in the hepatic sinusoidal endothelium?, Le Couteur D, McKinnon K, Fraser R, Cogger V, Sullivan D, National Health and Medical Research Council (NHMRC)/Project Grants
Mechanisms for ageing changes in the hepatic sinusoid, Le Couteur D, McKinnon K, Fraser R, Muller M, Cogger V, Harris M, Sullivan D, National Health and Medical Research Council (NHMRC)/Project Grants
Victor 3 Multi-label Plate Reader, Handelsman D, Kennerson M, Kril J, Kritharides L, Le Couteur D, Nicholson G, Seibel M, Witting P, University of Sydney/Major Equipment Grant
Bio-Rad iCycler iQ5 Real-Time PCR & Mutation detection system, Allan C, Dunstan C, Freedman B, Handelsman D, Kennerson M, Kril J, Le Couteur D, Muller M, Nicholson G, Seibel M, Witting P, National Health and Medical Research Council (NHMRC)/Equipment Grant

2003

Concord hormones and ageing in men project, Cumming R, Le Couteur D, Naganathan V, Handelsman D, Seibel M, Creasey H, Sambrook P, Waite L, National Health and Medical Research Council (NHMRC)/Project Grants
The aetiology of Parkinsons disease, Le Couteur D, National Health and Medical Research Council (NHMRC)/Project Grants
OPTIMAX TLX 120 ultracentrifuge, Handelsman D, Kennerson M, Kril J, Kritharides L, Lay P, Le Couteur D, Lowe H, Nicholson G, Witting P, National Health and Medical Research Council (NHMRC)/Equipment Grant
Digital stereo Investigator system, Allan C, Handelsman D, Illingworth P, Kril J, Le Couteur D, Nicholson G, National Health and Medical Research Council (NHMRC)/Equipment Grant
Dual Energy X-Ray (DEXA) densitometer hologic discovery W and software, Cumming R, Handelsman D, Le Couteur D, Mitchell P, Naganathan V, Sambrook P, Seibel M, National Health and Medical Research Council (NHMRC)/Equipment Grant

2002

The effect of hepatic pseudocapillarisation of old age on the disposition of chylomicron remnants and chylomicrons, Fraser R, Le Couteur D, McLean A, Sullivan D, National Health and Medical Research Council (NHMRC)/Project Grants
Australian Ageing Alliance. Application two: Geriatric pharmacology, Cumming R, Le Couteur D, National Health and Medical Research Council (NHMRC)/Strategic Research Development Committee (SDRC): Healthy Ageing
Axio vert 25CFL inverted microscope; Biolab safety cabinet; Biolab EMA incubator; Biolab EMA autoclave, Allan C, Handelsman D, Harris M, Kril J, Le Couteur D, National Health and Medical Research Council (NHMRC)/Equipment Grant

2001

Pharmacological, metabolic & therapeutic implications of the oxygen diffusion barrier hypothesis of ageing in the liver, Le Couteur D, Department of Veterans Affairs/Research Grant
Mass spectrometry upgrade to HPLC, Handelsman D, Illingworth P, Kril J, Le Couteur D, Lim J, Nicholson G, Seibel M, Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment

2000

Not known, Le Couteur D, DVC Research/Research and Development Scheme: Research and Development (R&D)
Scoping study on ageing research, Andrews D, Kendig H, Khalil Z, Le Couteur D, McCallum J, National Health and Medical Research Council (NHMRC)/Strategic Research Development Committee (SDRC): Healthy Ageing

1999

Waters high performance liquid chromatography (HPLC) system, Le Couteur D, National Health and Medical Research Council (NHMRC)/Equipment Grant
Hepatic oxygenation and aging, Le Couteur D, Ansselin A, McLean A, National Health and Medical Research Council (NHMRC)/Project Grants

Faculty of Medicine and Health

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Professor David Le Couteur

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