Associate Professor David Wang
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Associate Professor David Wang

Clinical Associate Professor
Woolcock Institute and Royal Prince Alfred Hospital, Central Clinical School
Phone
9515 5402
Fax
9515 7196
Associate Professor David Wang

Dr Wang (PhD, MAppSci, BMed, RPSGT) is a medical graduate from China and obtained his Masters Degree in insomnia research at RMIT University, and PhD in Clinical Sleep Medicine at the University of Melbourne. He moved to the University of Sydney in 2004. He was awarded a NHMRC Training Fellowship in 2009 and a NHMRC Project Grant as CI-A in 2013. He is a reviewer for NHMRC Project Grant and National Nature Science Foundation of China, and 10 peer-reviewed journals.

He has broad interest in sleep and breathing, ventilatory control, hypercapnia and hypoxia, drug effects, and neurocognitive functions. His major research interest is exploring the mechanisms of sleep-disordered breathing, and phenotyping relevant treatment/drug effects using awake ventilatory chemoreflex technique. He is also interested with exploring neuro-cognitive outcomes of sleep-disordered breathing, and relevant hypoxia and hypercapnia mechanisms.

Obesity, Diabetes and Cardiovascular Disease, Neurosciences and Mental Health, Healthy Ageing

Publications

Journals

  • Sivam, S., Wang, D., Wong, K., Piper, A., Zheng, Y., Gauthier, G., Hockings, C., Hockings, C., Menadue, C., Melehan, K., Cooper, S., Phillips, C., Yee, B., Grunstein, R., et al (2022). Cardiopulmonary coupling and serum cardiac biomarkers in obesity hypoventilation syndrome and obstructive sleep apnea with morbid obesity. The Journal of Clinical Sleep Medicine, 18(4), 1063-1071. [More Information]
  • McCarthy, K., Saripella, A., Selvanathan, J., Nagappa, M., Englesakis, M., Wang, D., Peng, P., Chung, F. (2022). Positive airway pressure therapy for chronic pain in patients with obstructive sleep apnea—a systematic review. Sleep and Breathing, 26(1), 47-55. [More Information]
  • Wang, D., Yee, B., Grunstein, R., Chung, F. (2021). Chronic Opioid Use and Central Sleep Apnea, Where Are We Now and Where To Go? A State of the Art Review. Anesthesia and Analgesia, 132(5), 1244-1253. [More Information]

2022

  • Sivam, S., Wang, D., Wong, K., Piper, A., Zheng, Y., Gauthier, G., Hockings, C., Hockings, C., Menadue, C., Melehan, K., Cooper, S., Phillips, C., Yee, B., Grunstein, R., et al (2022). Cardiopulmonary coupling and serum cardiac biomarkers in obesity hypoventilation syndrome and obstructive sleep apnea with morbid obesity. The Journal of Clinical Sleep Medicine, 18(4), 1063-1071. [More Information]
  • McCarthy, K., Saripella, A., Selvanathan, J., Nagappa, M., Englesakis, M., Wang, D., Peng, P., Chung, F. (2022). Positive airway pressure therapy for chronic pain in patients with obstructive sleep apnea—a systematic review. Sleep and Breathing, 26(1), 47-55. [More Information]

2021

  • Wang, D., Yee, B., Grunstein, R., Chung, F. (2021). Chronic Opioid Use and Central Sleep Apnea, Where Are We Now and Where To Go? A State of the Art Review. Anesthesia and Analgesia, 132(5), 1244-1253. [More Information]
  • Rowsell, L., Wu, J., Yee, B., Wong, K., Sivam, S., Somogyi, A., Grunstein, R., Wang, D. (2021). The effect of acute morphine on sleep in male patients suffering from sleep apnea: Is there a genetic effect? An RCT Study. Journal of Sleep Research, 30(4), e13249. [More Information]

2020

  • Wang, D., Phillips, C., Yee, B., Grunstein, R. (2020). Linking awake ventilatory chemosensitivity with opioid-induced respiratory depression during sleep-an important, but not a new, concept. Journal of Applied Physiology, 129(4), 932. [More Information]
  • Martins, R., Carberry, J., Wang, D., Rowsell, L., Grunstein, R., Eckert, D. (2020). Morphine alters respiratory control but not other key obstructive sleep apnoea phenotypes: A randomised trial. European Respiratory Journal, 55(6), 1901344. [More Information]
  • Sivam, S., Yee, B., Chadban, S., Piper, A., Hanly, P., Wang, D., Wong, K., Grunstein, R. (2020). Prevalence of chronic kidney disease in obesity hypoventilation syndrome and obstructive sleep apnoea with severe obesity. Sleep Medicine, 74, 73-77. [More Information]

2019

  • Wang, D., Yee, B., Grunstein, R. (2019). Does Sleep Apnea Worsen the Adverse Effects of Opioids and Benzodiazepines on Chronic Obstructive Pulmonary Disease? Annals of the American Thoracic Society, 16(10), 1237-1238. [More Information]
  • Rowsell, L., Wong, K., Yee, B., Eckert, D., Somogyi, A., Duffin, J., Grunstein, R., Wang, D. (2019). The effect of acute morphine on obstructive sleep apnoea: a randomised double-blind placebo-controlled crossover trial. Thorax, 74, 177-184. [More Information]

2018

  • Sivam, S., Yee, B., Wong, K., Wang, D., Grunstein, R., Piper, A. (2018). Obesity hypoventilation syndrome: Early detection of nocturnal-only hypercapnia in an obese population. The Journal of Clinical Sleep Medicine, 14(9), 1477-1484. [More Information]
  • Wang, D., Wong, K., Rowsell, L., Don, G., Yee, B., Grunstein, R. (2018). Predicting response to oxygen therapy in obstructive sleep apnoea patients using a 10-minute daytime test. European Respiratory Journal, 51(1), 1-9. [More Information]

2017

  • D'Rozario, A., Cross, N., Vakulin, A., Bartlett, D., Wong, K., Wang, D., Grunstein, R. (2017). Quantitative electroencephalogram measures in adult obstructive sleep apnea - Potential biomarkers of neurobehavioural functioning. Sleep Medicine Reviews, 36, 29-42. [More Information]

2016

  • Wang, D., Thomas, R., Yee, B., Grunstein, R. (2016). Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep disordered breathing. Journal of Applied Physiology, 120(12), 184-186. [More Information]
  • Wang, D., Thomas, R., Yee, B., Grunstein, R. (2016). Last Word on Viewpoint: Hypercapnia is more important than hypoxia in the neuro-outcomes of sleep-disordered breathing. Journal of Applied Physiology, 120(12), 1489-1489. [More Information]
  • Vakulin, A., D'Rozario, A., Kim, J., Watson, B., Cross, N., Wang, D., Coeytaux Jackson, A., Bartlett, D., Wong, K., Grunstein, R. (2016). Quantitative sleep EEG and polysomnographic predictors of driving simulator performance in obstructive sleep apnea. Clinical Neurophysiology, 127(2), 1428-1435. [More Information]

2015

  • Wang, D., Yee, B., Wong, K., Kim, J., Dijk, D., Duffin, J., Grunstein, R. (2015). Comparing the effect of hypercapnia and hypoxia on the electroencephalogram during wakefulness. Clinical Neurophysiology, 126(1), 103-109. [More Information]
  • Wang, D., Bai, X., Williams, S., Hua, S., Kim, J., Marshall, N., D'Rozario, A., Grunstein, R. (2015). Modafinil Increases Awake EEG Activation and Improves Performance in Obstructive Sleep Apnea During Continuous Positive Airway Pressure Withdrawal. Sleep, 38(8), 1297-1303. [More Information]
  • Wang, D., Lintzeris, N., Leung, S., Haber, P., Yee, B., Grunstein, R. (2015). Reversal of central sleep apnoea with change from methadone to buprenorphine-naloxone: a case report. European Respiratory Journal, 46(4), 1202-1205. [More Information]

2014

  • Wang, D., Piper, A., Yee, B., Wong, K., Kim, J., D'Rozario, A., Rowsell, L., Dijk, D., Grunstein, R. (2014). Hypercapnia is a Key Correlate of EEG Activation and Daytime Sleepiness in Hypercapnic Sleep Disordered Breathing Patients. The Journal of Clinical Sleep Medicine, 10(5), 517-522. [More Information]
  • Dempsey, J., Xie, A., Patz, D., Wang, D. (2014). Physiology in Medicine: Obstructive sleep apnea pathogenesis and treatment--considerations beyond airway anatomy. Journal of Applied Physiology, 116(1), 3-12. [More Information]
  • Wang, D., Rowsell, L., Yee, B. (2014). Positive airway pressure treatment for opioid-related central sleep apnea, where are we now? Sleep and Breathing, 18(2), 229-231. [More Information]

2013

  • Wang, D., Eckert, D., Grunstein, R. (2013). Drug effects on ventilatory control and upper airway physiology related to sleep apnea. Respiratory Physiology and Neurobiology, 188(3), 257-266. [More Information]
  • Wang, D., Somogyi, A., Yee, B., Wong, K., Kaur, J., Wrigley, P., Grunstein, R. (2013). The effects of a single mild dose of morphine on chemoreflexes and breathing in obstructive sleep apnea. Respiratory Physiology and Neurobiology, 185(3), 526-532. [More Information]
  • Killick, R., Wang, D., Hoyos, C., Yee, B., Grunstein, R., Liu, P. (2013). The effects of testosterone on ventilatory responses in men with obstructive sleep apnoea: a randomised, placebo-controlled trial. Journal of Sleep Research, 22(3), 331-336. [More Information]

2011

  • Wang, D., Marshall, N., Duffin, J., Yee, B., Wong, K., Noori, N., Ng, S., Grunstein, R. (2011). Phenotyping interindividual variability in obstructive sleep apnoea response to temazepam using ventilatory chemoreflexes during wakefulness. Journal of Sleep Research, 20(4), 526-532. [More Information]
  • Wang, D., Piper, A., Wong, K., Yee, B., Marshall, N., Dijk, D., Grunstein, R. (2011). Slow Wave Sleep in Patients with Respiratory Failure. Sleep Medicine, 12(4), 378-383. [More Information]

2009

  • Phillips, C., Yee, B., Trenell, M., Magnussen, J., Wang, D., Banerjee, D., Berend, N., Grunstein, R. (2009). Changes in regional adiposity and cardio-metabolic function following a weight loss program with sibutramine in obese men with obstructive sleep apnea. The Journal of Clinical Sleep Medicine, 5(5), 416-421. [More Information]

2008

  • Piper, A., Wang, D., Yee, B., Grunstein, R., Barnes, D. (2008). Randomised trial of CPAP vs bilevel support in the treatment of obesity hypoventilation syndrome without severe nocturnal desaturation. Thorax, 63(5), 395-401. [More Information]
  • Vedam, H., Phillips, C., Wang, D., Barnes, D., Hedner, J., Unger, G., Grunstein, R. (2008). Short-term hypoxia reduces arterial stiffness in healthy men. European Journal of Applied Physiology, 105(1), 19-25. [More Information]
  • Wang, D., Teichtahl, H., Goodman, C., Drummer, O., Grunstein, R., Kronborg, I. (2008). Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: Possible mechanisms. The Journal of Clinical Sleep Medicine, 4(6), 557-562. [More Information]

2007

  • Wang, D., Teichtahl, H. (2007). Opioids, sleep architecture and sleep-disordered breathing. Sleep Medicine Reviews, 11(1), 35-46. [More Information]
  • Teichtahl, H., Wang, D. (2007). Sleep-disordered breathing with chronic opioid use. Expert Opinion on Drug Safety, 6(6), 641-649. [More Information]

2006

  • Wang, D., Grunstein, R., Teichtahl, H. (2006). Association between ventilatory response to hypercapnia and obstructive sleep apnea-hypopnea index in asymptomatic subjects. Sleep and Breathing, 11(2), 103-108. [More Information]

2005

  • Wang, D., Teichtahl, H., Drummer, O., Goodman, C., Cherry, G., Cunnington, D., Kronborg, I. (2005). Central Sleep Apnea in Stable Methadone Maintenance Treatment Patients. Chest, 128(3), 1348-1356. [More Information]
  • Teichtahl, H., Wang, D., Cunnington, D., Quinnell, T., Tran, H., Kronborg, I., Drummer, O. (2005). Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients. Chest, 128(3), 1339-1347. [More Information]

2004

  • Teichtahl, H., Wang, D., Cunnington, D., Kronborg, H., Goodman, C., Prodromidis, A., Drummer, O. (2004). Cardiorespiratory function in stable methadone maintenance treatment (MMT) patients. Addiction Biology, 9(3-4), 247-253. [More Information]

2003

  • Teichtahl, H., Cunnington, D., Cherry, G., Wang, D. (2003). Scoring polysomnography respiratory events: the utility of nasal pressure and oro-nasal thermal sensor recordings. Sleep Medicine, 4(5), 419-425. [More Information]

Selected Grants

2012

  • Evaluating the effect of morphine on obstructive sleep apnea, Wang D, Eckert D, Somogyi A, Grunstein R, Wong K, National Health and Medical Research Council (NHMRC)/Project Grants

2009

  • Effect of opioids on breathing during sleep, Wang D, National Health and Medical Research Council (NHMRC)/Early Career Fellowships