Associate Professor Elizabeth Scott
Faculty of Medicine &
Health, Translational Research CollectiveBrain and Mind Centre, Youth Mental Health &
Technology
Associate Professor Elizabeth Scott has expertise in youth mood disorders, service developments for youth mental health, as well as sleep and circadian dysfunction. Until January 2021 she was the Medical Director of Uspace – inpatient services for young people with emerging psychiatric disorders at St Vincent’s Private Hospital. Associate Professor Scott is a Principal Research Fellow at the Brain and Mind Centre, University of Sydney and has extensive experience in developing and evaluating comprehensive assessment and management programs for young people with mental health problems through her work with the Brain & Mind Centre as well as the headspace programs in Central and Eastern Sydney.
Youth Mental Health and Technology Research projects are available via the website below.
https://www.sydney.edu.au/brain-mind/our-research/youth-mental-health-and-technology.html
Publications
Book Chapters
- Scott, E., Carpenter, J., Iorfino, F., Cross, S., Hermens, D., White, D., Lee, R., Naismith, S., Guastella, A., Glozier, N., Leweke, F., Koethe, D., Lagopoulos, J., Scott, J., Hamilton, B., Crouse, J., Tickell (nee Kennedy), A., Nichles, A., Zmicerevska, N., Gehue, L., Kaur, M., Chitty, K., Hickie, I. (2020). Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health care. In Bernhard T. Baune (Eds.), Personalized Psychiatry, (pp. 39-62). London: Elsevier. [More Information]
Journals
- Hopwood, M., Scott, E., Codyre, D., Barton, D., Puig, A., King, J., Joks, G., Hickie, I. (2024). A real-world study examining the impact of esketamine nasal spray in people living with major depressive disorder in Australia and New Zealand. Psychiatry Research Communications, 4(3). [More Information]
- Scott, J., Ratheesh, A., Raballo, A., Yung, A., Berk, M., Mckenna, S., Hockey, S., Hutcheon, A., Scott, E., McGorry, P., Iorfino, F., Hickie, I., Capon, W., Crouse, J., et al (2024). Staging 2.0: refining transdiagnostic clinical staging frameworks to enhance reliability and utility for youth mental health. The Lancet Psychiatry, 11(6), 461-471. [More Information]
- Capon, W., Hickie, I., Fetanat, M., Varidel, M., LaMonica, H., Prodan, A., Piper, S., Davenport, T., Mughal, S., Shah, J., Scott, E., Iorfino, F. (2023). A multidimensional approach for differentiating the clinical needs of young people presenting for primary mental health care. Comprehensive Psychiatry, 126. [More Information]
Magazine / Newspaper Articles
- Hickie, I., Davenport, T., Scott, E. (2003). Depression: Out of the Shadows. A Guide to Understanding Depression and its Treatment. The Australian Women’s Weekly Health Series.
- Scott, E., Hickie, I., Riches, J. (2002). Women's health and depression. Women’s Weekly Handout, 'Good Medicine'.
2024
- Hopwood, M., Scott, E., Codyre, D., Barton, D., Puig, A., King, J., Joks, G., Hickie, I. (2024). A real-world study examining the impact of esketamine nasal spray in people living with major depressive disorder in Australia and New Zealand. Psychiatry Research Communications, 4(3). [More Information]
- Scott, J., Ratheesh, A., Raballo, A., Yung, A., Berk, M., Mckenna, S., Hockey, S., Hutcheon, A., Scott, E., McGorry, P., Iorfino, F., Hickie, I., Capon, W., Crouse, J., et al (2024). Staging 2.0: refining transdiagnostic clinical staging frameworks to enhance reliability and utility for youth mental health. The Lancet Psychiatry, 11(6), 461-471. [More Information]
2023
- Capon, W., Hickie, I., Fetanat, M., Varidel, M., LaMonica, H., Prodan, A., Piper, S., Davenport, T., Mughal, S., Shah, J., Scott, E., Iorfino, F. (2023). A multidimensional approach for differentiating the clinical needs of young people presenting for primary mental health care. Comprehensive Psychiatry, 126. [More Information]
- Capon, W., Hickie, I., Mckenna, S., Varidel, M., Richards, M., LaMonica, H., Rock, D., Scott, E., Iorfino, F. (2023). Characterising variability in youth mental health service populations: A detailed and scalable approach using digital technology. Australasian Psychiatry. [More Information]
- Wilson, C., Carpenter, J., Crouse, J., Park, S., Koethe, D., Scott, E., Hickie, I. (2023). Cross-sectional and longitudinal associations between cardiometabolic measures and clinical stage in young people accessing early intervention mental health services. Early Intervention in Psychiatry. [More Information]
2022
- Scott, J., Etain, B., Grierson, A., Naismith, S., Scott, E., Hickie, I. (2022). A network analysis of rest-activity rhythms in young people with emerging bipolar disorders. Journal of Affective Disorders, 305, 220-226. [More Information]
- Capon, W., Hickie, I., Varidel, M., Prodan, A., Crouse, J., Carpenter, J., Cross, S., Nichles, A., Zmicerevska, N., Guastella, A., Scott, E., Iorfino, F., et al (2022). Clinical staging and the differential risks for clinical and functional outcomes in young people presenting for youth mental health care. BMC Medicine, 20(1). [More Information]
- Carpenter, J., Zmicerevska, N., Crouse, J., Nichles, A., Garland, A., Song, C., Wilson, C., Rohleder, C., McHugh, C., Leweke, F., Koethe, D., Scott, E., Hickie, I. (2022). Effects of adjunctive brexpiprazole on sleep-wake and circadian parameters in youth with depressive disorders: study protocol for a clinical trial. BMJ Open, 12(9). [More Information]
2021
- Carpenter, J., Crouse, J., Scott, E., Naismith, S., Wilson, C., Scott, J., Merikangas, K., Hickie, I. (2021). Circadian depression: A mood disorder phenotype. Neuroscience and Biobehavioral Reviews, 126, 79-101. [More Information]
- Crouse, J., Carpenter, J., Song, C., Hockey, S., Naismith, S., Grunstein, R., Scott, E., Merikangas, K., Scott, J., Hickie, I. (2021). Circadian rhythm sleep–wake disturbances and depression in young people: implications for prevention and early intervention. The Lancet Psychiatry, 8(9), 813-823. [More Information]
- Park, S., Song, C., Demetriou, E., Pepper, K., Hickie, I., Glozier, N., Hermens, D., Scott, E., Guastella, A. (2021). Distress, quality of life and disability in treatment-seeking young adults with social anxiety disorder. Early Intervention in Psychiatry, 15(1), 57-67. [More Information]
2020
- Carpenter, J., Iorfino, F., Cross, S., Nichles, A., Zmicerevska, N., Crouse, J., Palmer, J., Whitton, A., White, D., Naismith, S., Guastella, A., Hermens, D., Scott, J., Scott, E., Hickie, I. (2020). Cohort profile: The Brain and Mind Centre Optymise cohort: Tracking multidimensional outcomes in young people presenting for mental healthcare. BMJ Open, 10(3), e030985. [More Information]
- Scott, E., Carpenter, J., Iorfino, F., Cross, S., Hermens, D., White, D., Lee, R., Naismith, S., Guastella, A., Glozier, N., Leweke, F., Koethe, D., Lagopoulos, J., Scott, J., Hamilton, B., Crouse, J., Tickell (nee Kennedy), A., Nichles, A., Zmicerevska, N., Gehue, L., Kaur, M., Chitty, K., Hickie, I. (2020). Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health care. In Bernhard T. Baune (Eds.), Personalized Psychiatry, (pp. 39-62). London: Elsevier. [More Information]
- Davenport, T., Cheng, W., Iorfino, F., Hamilton, B., Castaldi, E., Burton, A., Scott, E., Hickie, I. (2020). Flip the clinic: A digital health approach to youth mental health service delivery during the COVID-19 pandemic and beyond. JMIR Mental Health, 7(12), e24578. [More Information]
2019
- Grierson, A., Scott, J., Glozier, N., Hickie, I., Amminger, P., Killackey, E., McGorry, P., Pantelis, C., Phillips, L., Scott, E., et al (2019). Can youth at high risk of illness progression be identified by measures of rumination and sleep-wake disturbance. Early Intervention in Psychiatry, 13(5), 1214-1219. [More Information]
- Iorfino, F., Scott, E., Carpenter, J., Cross, S., Hermens, D., Killedar, M., Nichles, A., Zmicerevska, N., White, D., Guastella, A., Hickie, I., et al (2019). Clinical Stage Transitions in Persons Aged 12 to 25 Years Presenting to Early Intervention Mental Health Services with Anxiety, Mood, and Psychotic Disorders. JAMA Psychiatry, 76(11), 1167-1175. [More Information]
- Crouse, J., Chitty, K., Iorfino, F., White, D., Nichles, A., Zmicerevska, N., Guastella, A., Moustafa, A., Hermens, D., Scott, E., Hickie, I. (2019). Exploring associations between early substance use and longitudinal socio-occupational functioning in young people engaged in a mental health service. PloS One, 14(1), 1-18. [More Information]
2018
- Robillard, R., Carpenter, J., Rogers, N., Fares, S., Grierson, A., Hermens, D., Naismith, S., Mullin, S., Fields, K., Glozier, N., Scott, E., Hickie, I. (2018). Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders. Translational Psychiatry, 8, 213. [More Information]
- Lee, R., Hermens, D., Naismith, S., Kaur, M., Guastella, A., Glozier, N., Scott, J., Scott, E., Hickie, I. (2018). Clinical, neurocognitive and demographic factors associated with functional impairment in the Australian Brain and Mind Youth Cohort Study (2008-2016). BMJ Open, 8(12), 1-10. [More Information]
- Iorfino, F., Hermens, D., Cross, S., Zmicerevska, N., Nichles, A., Badcock, C., Groot, J., Scott, E., Hickie, I. (2018). Delineating the trajectories of social and occupational functioning of young people attending early intervention mental health services in Australia: a longitudinal study. BMJ Open, 8(3), e020678. [More Information]
2017
- Lee, R., Hermens, D., Scott, J., O’Dea, B., Glozier, N., Scott, E., Hickie, I. (2017). A transdiagnostic study of education, employment, and training outcomes in young people with mental illness. Psychological Medicine, 47(12), 2061-2070. [More Information]
- Robillard, R., Lagopoulos, J., Hermens, D., Naismith, S., Rogers, N., White, D., Carpenter, J., Kaur, M., Scott, E., Hickie, I. (2017). Lower in vivo myo-inositol in the anterior cingulate cortex correlates with delayed melatonin rhythms in young persons with depression. Frontiers in Neuroscience, 11, 1-6. [More Information]
- Carpenter, J., Robillard, R., Hermens, D., Naismith, S., Gordon, C., Scott, E., Hickie, I. (2017). Sleep-wake profiles and circadian rhythms of core temperature and melatonin in young people with affective disorders. Journal of Psychiatric Research, 94, 131-138. [More Information]
2016
- Grierson, A., Hickie, I., Naismith, S., Hermens, D., Scott, E., Scott, J. (2016). Circadian rhythmicity in emerging mood disorders: state or trait marker? International Journal of Bipolar Disorders, 4(1), 1-7. [More Information]
- Scott, E., Robillard, R., Hermens, D., Naismith, S., Rogers, N., Ip, T., White, D., Guastella, A., Whitwell, B., Smith, K., Hickie, I. (2016). Dysregulated sleep-wake cycles in young people are associated with emerging stages of major mental disorders. Early Intervention in Psychiatry, 10(1), 63-70. [More Information]
- Banihashemi, N., Robillard, R., Yang, J., Carpenter, J., Hermens, D., Naismith, S., Terpening, Z., White, D., Scott, E., Hickie, I. (2016). Quantifying the effect of body mass index, age, and depression severity on 24-h activity patterns in persons with a lifetime history of affective disorders. BMC Psychiatry, 16(1), 1-11. [More Information]
2015
- Cacciotti-Saija, C., Langdon, R., Ward, P., Hickie, I., Scott, E., Naismith, S., Moore, L., Alvares, G., Redoblado-Hodge, M., Guastella, A. (2015). A Double-blind Randomized Controlled Trial of Oxytocin Nasal Spray and Social Cognition Training for Young People With Early Psychosis. Schizophrenia Bulletin, 41(2), 483-493. [More Information]
- Guastella, A., Ward, P., Hickie, I., Shahrestani, S., Redoblado Hodge, M., Scott, E., Langdon, R. (2015). A single dose of oxytocin nasal spray improves higher-order social cognition in schizophrenia. Schizophrenia Research, 168(3), 628-633. [More Information]
- Robillard, R., Hermens, D., Naismith, S., White, D., Rogers, N., Ip, T., Mullin, S., Alvares, G., Guastella, A., Smith, K., Whitwell, B., Southan, J., Glozier, N., Scott, E., Hickie, I., et al (2015). Ambulatory sleep-wake patterns and variability in young people with emerging mental disorders. Journal of Psychiatry & Neuroscience, 40(1), 28-37. [More Information]
2014
- Cross, S., Hermens, D., Scott, E., Ottavio, A., McGorry, P., Hickie, I. (2014). A Clinical Staging Model for Early Intervention Youth Mental Health Services. Psychiatric Services, 65(7), 939-943. [More Information]
- O'Dea, B., Glozier, N., Purcell, R., McGorry, P., Scott, J., Fields, K., Hermens, D., Buchanan, J., Scott, E., Yung, A., Guastella, A., Hickie, I., et al (2014). A cross-sectional exploration of the clinical characteristics of disengaged (NEET) young people in primary mental healthcare. BMJ Open, 4(12), 1-8. [More Information]
- Bennett, B., Goldstein, D., Chen, M., Davenport, T., Vollmer-Conna, U., Scott, E., Hickie, I., Lloyd, A. (2014). Characterization of Fatigue States in Medicine and Psychiatry by Structured Interview. Psychosomatic Medicine, 76(5), 379-388. [More Information]
2013
- Hickie, I., Scott, E., Hermens, D., Naismith, S., Guastella, A., Kaur, M., Sidis, A., Whitwell, B., Glozier, N., Davenport, T., et al (2013). Applying clinical staging to young people who present for mental health care. Early Intervention in Psychiatry, 7(1), 31-43. [More Information]
- Hickie, I., Scott, J., Hermens, D., Scott, E., Naismith, S., Guastella, A., Glozier, N., McGorry, P. (2013). Clinical classification in mental health at the cross-roads: which direction next? BMC Medicine, 11(1), 1-14. [More Information]
- Hatton, S., Lagopoulos, J., Hermens, D., Scott, E., Hickie, I., Bennett, M. (2013). Cortical thinning in young psychosis and bipolar patients correlate with common neurocognitive deficits. International Journal of Bipolar Disorders, 1(3), 1-13. [More Information]
2012
- Goldstein, D., Bennett, B., Webber, K., Boyle, F., De Souza, P., Wilcken, N., Scott, E., Toppler, R., Murie, P., O'Malley, L., Hickie, I., et al (2012). Cancer-Related Fatigue in Women With Breast Cancer: Outcomes of a 5-Year Prospective Cohort Study. Journal of Clinical Oncology, 30(15), 1805-1812. [More Information]
- Naismith, S., Hermens, D., Ip, T., Bolitho, S., Scott, E., Rogers, N., Hickie, I. (2012). Circadian profiles in young people during the early stages of affective disorder. Translational Psychiatry, 2(2012), 1-6. [More Information]
- Clarke, P., Hickie, I., Scott, E., Guastella, A. (2012). Clinical staging model applied to young people presenting with social anxiety. Early Intervention in Psychiatry, 6(3), 256-264. [More Information]
2011
- Hamilton, B., Naismith, S., Scott, E., Purcell, S., Hickie, I. (2011). Disability is already pronounced in young people with early stages of affective disorders: Data from an early intervention service. Journal of Affective Disorders, 131(1-3), 84-91. [More Information]
- Hermens, D., Redoblado Hodge, M., Naismith, S., Kaur, M., Scott, E., Hickie, I. (2011). Neuropsychological Clustering Highlights Cognitive Differences In Young People Presenting With Depressive Symptoms. Journal of the International Neuropsychological Society, 17(2), 267-276. [More Information]
2010
- Naismith, S., Redoblado Hodge, M., Hermens, D., Carter, P., Scott, E., Hickie, I. (2010). Cognitive Training Improves Cognitive and Psychosocial Functioning in a Mixed Psychiatric Outpatient Sample. Journal of Cognitive Rehabilitation, 121(3), 258-262.
- Naismith, S., Redoblado Hodge, M., Lewis, S., Scott, E., Hickie, I. (2010). Cognitive training in affective disorders improves memory: A preliminary study using the NEAR approach. Journal of Affective Disorders, 121(3), 258-262. [More Information]
- Hermens, D., Naismith, S., Redoblado Hodge, M., Scott, E., Hickie, I. (2010). Impaired verbal memory in young adults with unipolar and bipolar depression. Early Intervention in Psychiatry, 4(3), 227-233. [More Information]
2009
- Scott, E., Naismith, S., Whitwell, B., Hamilton, B., Chudleigh, C., Hickie, I. (2009). Delivering youth-specific mental health services: the advantages of a collaborative, multi-disciplinary system. Australasian Psychiatry, 17(2), 189-194. [More Information]
- Naismith, S., Norrie, L., Lewis, S., Rogers, N., Scott, E., Hickie, I. (2009). Does sleep disturbance mediate neuropsychological functioning in older people with depression? Journal of Affective Disorders, 116(1-2), 139-143. [More Information]
- Naismith, S., Glozier, N., Burke, D., Carter, P., Scott, E., Hickie, I. (2009). Early intervention in cognitive decline: Is there a role for multiple medical or behavioural interventions? Early Intervention in Psychiatry, 3(1), 19-27. [More Information]
2007
- Naismith, S., Longley, W., Scott, E., Hickie, I. (2007). Disability in major depression related to self-rated and objectively-measured cognitive deficits: A preliminary study. BMC Psychiatry, 7, 32-1-32-7. [More Information]
- Hickie, I., Naismith, S., Ward, P., Little, C., Pearson, M., Scott, E., Mitchell, P., Wilhelm, K., Parker, G. (2007). Psychomotor slowing in older persons with major depression: relationships with blood flow in the caudate nucleus and white matter lesions. Psychiatry Research: Neuroimaging, 155(3), 211-220. [More Information]
2006
- Naismith, S., Hickie, I., Ward, P., Scott, E., Little, C. (2006). Impaired implicit sequence learning in depression: a probe for frontostriatal dysfunction? Psychological Medicine, 36(3), 313-323. [More Information]
- Hickie, I., Davenport, T., Luscombe, G., Scott, E., Mackenzie, E., Morgan, H., Wilson, A., Barton, D., Barrett, E. (2006). Is real reform of the Medicare Benefits Schedule for psychiatrists in Australia economically, socially or professionally desirable? Australasian Psychiatry, 14(1), 8-14. [More Information]
- Hickie, I., Naismith, S., Ward, P., Scott, E., Mitchell, P., Schofield, P., Scimone, A., Wilhelm, K., Parker, G. (2006). Serotonin transporter gene status predicts caudate nucleus but not amygdala or hippocampal volumes in older persons with major depression. Journal of Affective Disorders, 98(1-2), 137-142. [More Information]
2005
- Hickie, I., Naismith, S., Ward, P., Turner, K., Scott, E., Mitchell, P., Wilhelm, K., Parker, G. (2005). Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression. British Journal of Psychiatry, 186, 197-202. [More Information]
- Hickie, I., Naismith, S., Ward, P., Scott, E., Mitchell, P., Wilhelm, K., Parker, G. (2005). Vascular risk and low serum B12 predict white matter lesions in patients with major depression. Journal of Affective Disorders, 85(3), 327-332. [More Information]
2003
- Hickie, I., Scott, E., Davenport, T., Gillies, K., Ricci, C. (2003). 'SPHERE: a national depression project'. Providing enhanced care in the general practice setting. Depression Awareness Journal, 12, 6-7.
- Hickie, I., Davenport, T., Scott, E. (2003). Depression: Out of the Shadows. A Guide to Understanding Depression and its Treatment. The Australian Women’s Weekly Health Series.
- Blashki, G., Hickie, I., Littlefield, L., Scott, E., Pirkis, J., Groom, G., Richards, J., Davenport, T. (2003). Referral of patients with depression to specialist psychological care from general practice. Australian Family Physician, 32(12), 998-1002.
2002
- Naismith, S., Hickie, I., Ward, P., Turner, K., Scott, E., Little, C., Mitchell, P., Wilhelm, K., Parker, G. (2002). Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older patients with depression. American Journal of Psychiatry, 159, 2096-2098. [More Information]
- Hickie, I., Davenport, T., Scott, E., Morgan, H. (2002). E-health responses to common mental disorders in primary care – experiences with beyondblue: the national depression initiative and ‘SPHERE: a national depression project’. Australasian Psychiatry, 10, 253-258. [More Information]
- Hickie, I., Davenport, T., Scott, E., Naismith, S. (2002). Letter: SPHERE: A National Depression Project. Medical Journal of Australia, 176, 194.
2001
- Hickie, I., Koschera, A., Davenport, T., Naismith, S., Scott, E. (2001). Comorbidity of common mental disorders and alcohol or other substance misuse in Australian general practice. Medical Journal of Australia, 175, S31-S36.
- Hickie, I., Davenport, T., Naismith, S., Scott, E. (2001). Conclusions about the assessment and management of common mental disorders in Australian general practice. Medical Journal of Australia, 175, S52-S55.
- Hickie, I., Davenport, T., Hadzi-Pavlovic, D., Koschera, A., Naismith, S., Scott, E., Wilhelm, Jr., K. (2001). Development of a simple screening tool for common mental disorders in general practice. Medical Journal of Australia, 175, S10-S17.
1998
- Hickie, I., Hadzi-Pavlovic, D., Scott, E., Davenport, T., Koschera, A., Naismith, S. (1998). SPHERE: A National Depression Project. Australasian Psychiatry, 6(5), 248-250. [More Information]
Selected Grants
2021
- A large-scale clinical effectiveness (health services research) trial of personalised health care packages and digitally-supported measurement-based care, to improve functional outcomes in young people with mood disorders, Hickie I, McGorry P, Leweke F, Guastella A, Scott J, Scott E, Mihalopoulos C, Cripps S, Iorfino F, Rohleder C, National Health and Medical Research Council (NHMRC)/Clinical Trials and Cohort Studies
2019
- Reducing suicidal thoughts and behaviours in young people presenting for health care, Hickie I, McGorry P, Robinson J, Chanen A, Page A, Atkinson J, Scott E, Judkins S, Buus N, National Health and Medical Research Council (NHMRC)/Centres of Research Excellence