Professor Edmund Lau
People_

Professor Edmund Lau

Clinical Professor
Sydney Medical School
Central Clinical School
Faculty of Medicine and Health
Phone
9515 8195
Fax
9515 8196
Professor Edmund Lau
Prof Edmund Lau is a respiratory and sleep physician and currently holds appointment as Senior Staff Specialist at the Royal Prince Alfred Hospital. He has a PhD in pulmonary vascular medicine from University of Sydney. He worked at the French National Referral Centre for Severe Pulmonary Hypertension as a post-doctoral fellow prior to returning to Australia.He has participated as member of international task force on the pulmonary circulation. He is currently the medical director of the Pulmonary Hypertension Society of Australia and New Zealand (PHSANZ) Registry.
He has consistently published in high impact journals such as Lancet Respiratory, Circulation, European Heart Journal and European Respiratory Journal. He is on the editorial board of the European Respiratory Review.
Main research theme focuses on a devastating disease known as pulmonary arterial hypertension (PAH), which causes blockage of the small blood vessels of the lungs. Areas of research in PAH encompass:
  1. Epidemiological studies with the Australian and New Zealand Pulmonary Hypertension Registry.
  2. Functional imaging of the right ventricle-pulmonary circulation.
  3. Exercise physiology of the pulmonary circulation.
  4. Novel therapies for PAH.

Honors and PhD projects opportunities are available

Obesity, Diabetes and Cardiovascular Disease

Publications

Journals

  • Lau, E., Bloomfield, P., Kotlyar, E., Makanji, Y., Yu, D., Tan, J., Casorso, J., Kouhkamari, M., Lim, S., Wu, D. (2024). Comparative adherence of macitentan versus ambrisentan and bosentan in Australian patients with pulmonary arterial hypertension: a retrospective real-world database study. Journal of Medical Economics, 27(1), 596-604. [More Information]
  • Kearney, K., Keogh, A., Kotlyar, E., Lavender, M., McWilliams, T., Williams, T., Whitford, H., Weintraub, R., Wrobel, J., Ellender, C., Lau, E., Celermajer, D., Cordina, R., et al (2024). Impact of Left Heart Disease Risk Factors on Outcomes in Pulmonary Arterial Hypertension Therapy. Chest. [More Information]
  • Hungerford, S., Kearney, K., Li, C., Song, N., Everett, K., Gulati, G., Olsen, N., Lau, E., Jabbour, A., Bart, N., et al (2024). Pulsatile Vascular Afterload Measurement Improves Prediction of Right-Sided Heart Dysfunction in Undifferentiated and Left-Sided Pulmonary Hypertension. Journal of the American Heart Association, 13(23). [More Information]

2024

  • Lau, E., Bloomfield, P., Kotlyar, E., Makanji, Y., Yu, D., Tan, J., Casorso, J., Kouhkamari, M., Lim, S., Wu, D. (2024). Comparative adherence of macitentan versus ambrisentan and bosentan in Australian patients with pulmonary arterial hypertension: a retrospective real-world database study. Journal of Medical Economics, 27(1), 596-604. [More Information]
  • Kearney, K., Keogh, A., Kotlyar, E., Lavender, M., McWilliams, T., Williams, T., Whitford, H., Weintraub, R., Wrobel, J., Ellender, C., Lau, E., Celermajer, D., Cordina, R., et al (2024). Impact of Left Heart Disease Risk Factors on Outcomes in Pulmonary Arterial Hypertension Therapy. Chest. [More Information]
  • Hungerford, S., Kearney, K., Li, C., Song, N., Everett, K., Gulati, G., Olsen, N., Lau, E., Jabbour, A., Bart, N., et al (2024). Pulsatile Vascular Afterload Measurement Improves Prediction of Right-Sided Heart Dysfunction in Undifferentiated and Left-Sided Pulmonary Hypertension. Journal of the American Heart Association, 13(23). [More Information]

2023

  • Karimi Galougahi, K., Zhang, Y., Kienzle, V., Liu, C., Quek, L., Patel, S., Lau, E., Cordina, R., Figtree, G., Celermajer, D. (2023). β3 adrenergic agonism: A novel pathway which improves right ventricular-pulmonary arterial hemodynamics in pulmonary arterial hypertension. Physiological Reports, 11(1). [More Information]
  • Chandrasekara, S., Lau, E., Anderson, J., Collins, N., Cordina, R., Corrigan, C., Dwyer, N., Feenstra, J., Horrigan, M., Keogh, A., et al (2023). Acute Vasoreactivity Testing and Outcomes in Pulmonary Arterial Hypertension: A Call for Increased Testing. Heart, Lung, and Circulation, 32(2), 156-165. [More Information]
  • Hungerford, S., Kearney, K., Song, N., Kotlyar, E., Bart, N., Lau, E., Jabbour, A., Hayward, C., Muller, D., Adji, A. (2023). Characteristic changes to pulsatile and steady-state load according to pulmonary hypertension classification. Physiological Reports, 11(7). [More Information]

2022

  • Othman, F., Bailey, B., Collins, N., Lau, E., Tanous, D., Rao, K., Celermajer, D., Cordina, R. (2022). Platypnea-Orthodeoxia Syndrome in the Setting of Patent Foramen Ovale Without Pulmonary Hypertension or Major Lung Disease. Journal of the American Heart Association, 11(15). [More Information]
  • Anderson, J., Lau, E. (2022). Pulmonary Hypertension Definition, Classification, and Epidemiology in Asia. JACC: Asia, 2(5), 538-546. [More Information]
  • Bell, J., Sivam, S., Dentice, R., Dwyer, T., Jo, H., Lau, E., Munoz, P., Nolan, S., Taylor, N., Visser, S., Yozghatlian, V., Wong, K. (2022). Quality of home spirometry performance amongst adults with cystic fibrosis. Journal of Cystic Fibrosis, 21(1), 84-87. [More Information]

2021

  • Jee, A., Parker, M., Bleasel, J., Troy, L., Lau, E., Jo, H., Teoh, A., Adelstein, S., Webster, S., Corte, T. (2021). Baseline Characteristics and Survival of an Australian Interstitial Pneumonia with Autoimmune Features Cohort. Respiration, 100(9), 853-864. [More Information]
  • Kearney, K., Gold, J., Corrigan, C., Dhital, K., Boshell, D., Haydock, D., McGiffin, D., Wilson, M., Collins, N., Cordina, R., Lau, E., et al (2021). Chronic thromboembolic pulmonary hypertension in Australia and New Zealand: An analysis of the PHSANZ registry. Respirology, 26(12), 1171-1180. [More Information]
  • Cooper, W., Mahar, A., Myers, J., Grainge, C., Corte, T., Williamson, J., Vallely, M., Lai, S., Mulyadi, E., Torzillo, P., Lau, E., Troy, L., et al (2021). Cryobiopsy for Identification of Usual Interstitial Pneumonia and Other Interstitial Lung Disease Features: Further Lessons from COLDICE, a Prospective Multi-Center Study. American Journal of Respiratory and Critical Care Medicine, 203(10), 1306-1313. [More Information]

2020

  • Troy, L., Grainge, C., Corte, T., Williamson, J., Vallely, M., Cooper, W., Mahar, A., Myers, J., Lai, S., Mulyadi, E., Torzillo, P., Jo, H., Harris, B., Lau, E., et al (2020). Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study. The Lancet Respiratory Medicine, 8(2), 171-181. [More Information]
  • Khou, V., Anderson, J., Strange, G., Corrigan, C., Collins, N., Celermajer, D., Dwyer, N., Feenstra, J., Horrigan, M., Keating, D., Lau, E., et al (2020). Diagnostic delay in pulmonary arterial hypertension: Insights from the Australian and New Zealand pulmonary hypertension registry. Respirology, 25(8), 863-871. [More Information]
  • Lau, E., Grainge, C., Williamson, J., Corte, T., Cooper, W., Phillips, M., Torzillo, P., Vallely, M., Raghu, G., Troy, L. (2020). Methodologies of COLDICE and Cryo-PID studies: details make the difference. Annals of Translational Medicine, 8(12), 781. [More Information]

2019

  • Troy, L., Grainge, C., Corte, T., Williamson, J., Vallely, M., Cooper, W., Mahar, A., Lai, S., Mulyadi, E., Torzillo, P., Lau, E., et al (2019). Cryobiopsy versus open lung biopsy in the diagnosis of interstitial lung disease (COLDICE): protocol of a multicentre study. BMJ Open Respiratory Research, 6(1), 1-8. [More Information]
  • Chemla, D., Boulate, D., Weatherald, J., Lau, E., Attal, P., Savale, L., Montani, D., Fadel, E., Mercier, O., Sitbon, O., et al (2019). Golden ratio and the proportionality between pulmonary pressure components in pulmonary arterial hypertension. Chest, 155(5), 991-998. [More Information]
  • Troy, L., Young, I., Lau, E., Wong, K., Yee, B., Torzillo, P., Corte, T. (2019). Nocturnal hypoxaemia is associated with adverse outcomes in interstitial lung disease. Respirology, 24(10), 996-1004. [More Information]

2018

  • Rutting, S., Xenaki, D., Lau, E., Horvat, J., Wood, L., Hansbro, P., Oliver, B. (2018). Dietary omega-6, but not omega-3 polyunsaturated or saturated fatty acids, increase inflammation in primary lung mesenchymal cells. AJP: Lung Cellular and Molecular Physiology, 314(6), L922-L935. [More Information]
  • Phan, K., Jo, H., Xu, J., Lau, E. (2018). Medical Therapy Versus Balloon Angioplasty for CTEPH: A Systematic Review and Meta-Analysis. Heart, Lung, and Circulation, 27(1), 89-98. [More Information]
  • Tran, D., Lau, E., Celermajer, D., Davis, G., Cordina, R. (2018). Pathophysiology of exercise intolerance in pulmonary arterial hypertension. Respirology, 23(2), 148-159. [More Information]

2017

  • Kovacs, G., Herve, P., Barbera, J., Chaouat, A., Chemla, D., Condliffe, R., Garcia, G., Grunig, E., Howard, L., Humbert, M., et al (2017). An official European Respiratory Society statement: pulmonary haemodynamics during exercise. European Respiratory Journal, 50(5), 1-18. [More Information]
  • Weatherald, J., Boucly, A., Lau, E., Godinas, L., Savale, L., Jais, X., Montani, D., Sitbon, O., Simonneau, G., Humbert, M., et al (2017). Are indexed values better for defining exercise pulmonary hypertension? European Respiratory Journal, 50(3), 1-4. [More Information]
  • Montani, D., Girerd, B., Jais, X., Levy, M., Amar, D., Savale, L., Dorfmuller, P., Seferian, A., Lau, E., Eyries, M., et al (2017). Clinical phenotypes and outcomes of heritable and sporadic pulmonary veno-occlusive disease: a population-based study. The Lancet Respiratory Medicine, 5(2), 125-134. [More Information]

2016

  • Thakkar, V., Lau, E. (2016). Connective tissue disease-related pulmonary arterial hypertension. Best Practice & Research: Clinical Rheumatology, 30(1), 22-38. [More Information]
  • Godinas, L., Lau, E., Chemla, D., Lador, F., Savale, L., Montani, D., Jais, X., Sitbon, O., Simonneau, G., Humbert, M., et al (2016). Diagnostic concordance of different criteria for exercise pulmonary hypertension in subjects with normal resting pulmonary artery pressure. European Respiratory Journal, 48(1), 254-257. [More Information]
  • Lau, E., Chemla, D., Whyte, K., Kovacs, G., Olschewski, H., Herve, P. (2016). Does exercise pulmonary hypertension exist? Current Opinion in Pulmonary Medicine, 22(5), 400-407. [More Information]

2015

  • Lau, E., Humbert, M. (2015). A Critical Appraisal of the Updated 2014 Nice Pulmonary Hypertension Classification System. Canadian Journal of Cardiology, 31(4), 367-374. [More Information]
  • Fabrice, A., Benoît, R., Valérie, N., Lau, E., Sébastien, B., Frédéric, P. (2015). A simple method to assess in vivo proliferation in lung vasculature with EdU: The case of MMC-induced PVOD in rat. Analytical Cellular Pathology, 2015. [More Information]
  • Ranchoux, B., Günther, S., Quarck, R., Chaumais, M., Dorfmüller, P., Antigny, F., Dumas, S., Raymond, N., Lau, E., Savale, L., et al (2015). Chemotherapy-induced pulmonary hypertension: Role of alkylating agents. American Journal of Pathology, 185(2), 356-371. [More Information]

2014

  • Marc, H., Lau, E., Montani, D., Jais, X., Sitbon, O., Simonneau, G. (2014). Advances in Therapeutic Interventions for Patients With Pulmonary Arterial Hypertension. Circulation, 130(24), 2189-2208. [More Information]
  • Lau, E., Abelson, D., Dwyer, N., Yu, Y., Ng, M., Celermajer, D. (2014). Assessment of ventriculo-arterial interaction in pulmonary arterial hypertension using wave intensity analysis. European Respiratory Journal, 43(6), 1804-1807. [More Information]
  • Lau, E., Vanderpool, R., Choudhary, P., Simmons, L., Corte, T., Argiento, P., DAlto, M., Naeije, R., Celermajer, D. (2014). Dobutamine Stress Echocardiography for the Assessment of Pressure-Flow Relationships of the Pulmonary Circulation. Chest, 146(4), 959-966. [More Information]

2013

  • Lau, E., Morgan, P., Belousova, E., Toelle, B., Ayer, J., Celermajer, D., Marks, G. (2013). Asymmetric dimethylarginine and asthma: results from the Childhood Asthma Prevention Study. European Respiratory Journal, 41(5), 1234-1237. [More Information]
  • Lau, E., Jaijee, S., Melehan, K., Wong, K., Yee, B., Grunstein, R., Celermajer, D. (2013). Prevalence of patent foramen ovale and its impact on oxygen desaturation in obstructive sleep apnea. International Journal of Cardiology, 165(1), 35-40. [More Information]

2012

  • Lau, E., McCaughan, G., Torzillo, P. (2012). A case of portopulmonary hypertension spanning 18 years: successful use of bosentan for progressive disease after two liver transplantations. Internal Medicine Journal, 42(5), 600-601. [More Information]
  • Lau, E., Iyer, N., Ilsar, R., Bailey, B., Adams, M., Celermajer, D. (2012). Abnormal Pulmonary Artery Stiffness in Pulmonary Arterial Hypertension: In Vivo Study with Intravascular Ultrasound. PloS One, 7(3), 1-6. [More Information]
  • Lau, E., Corte, T. (2012). Pulmonary hypertension in 2012: contemporary issues in diagnosis and management. Panminerva Medica, 54(1), 11-28. [More Information]

2011

  • Lau, E., Cooper, W., Bye, P., Yan, K. (2011). Difficult asthma and Churg-Strauss-like syndrome: A cautionary tale. Respirology, 16(1), 180-181. [More Information]
  • Lau, E., Manes, A., Celermajer, D., Galie, N. (2011). Early detection of pulmonary vascular disease in pulmonary arterial hypertension: time to move forward. European Heart Journal, 32(20), 2489-2498. [More Information]
  • Bye, P., Lau, E., Elkins, M. (2011). Pharmacological airway clearance strategies in bronchiectasis. European Respiratory Monograph, , 239-247.

2010

  • Lau, E., McCaughan, G., Torzillo, P. (2010). Improvement in hepatopulmonary syndrome after methadone withdrawal: a case report with implications for disease mechanism. Liver Transplantation, 16(7), 870-873. [More Information]
  • Lau, E., Yee, B., Grunstein, R., Celermajer, D. (2010). Patent foramen ovale and obstructive sleep apnea: A new association? Sleep Medicine Reviews, 14(6), 391-395. [More Information]

2009

  • Lau, E., Yozghatlian, V., Kosky, C., Moriarty, C., Dentice, R., Waugh, R., Torzillo, P., Bye, P. (2009). Recombinant activated factor VII for massive hemoptysis in patients with cystic fibrosis. Chest, 136(1), 277-281. [More Information]

Selected Grants

2015

  • Crybiopsy versus Surgical Lung Biopsy for Diagnosis of Interstitial Lung Diseases, Lau E, University of Sydney/Kickstart Grants Program

2014

  • Exhaled Breath Olfactory Signature of Pulmonary Arterial Hypertension Detected by an Artificial Nose: A Proof-of-concept Validation Study , Lau E, Office of Global Engagement/Joint Funding Scheme with Inserm (France)