2024

• Ryalls, B., Patel, M., Sparkes, E., Banister, S., Finlay, D., Glass, M. (2024). Investigating selectivity and bias for G protein subtypes and β-arrestins by synthetic cannabinoid receptor agonists at the cannabinoid CB1 receptor. Biochemical Pharmacology, 222, 116052. [More Information]
• Sparkes, E., Maloney, C., Markham, J., Dane, C., Boyd, R., Gilchrist, J., Moir, M., Gordon, R., Luo, J., Pike, E., Walker, K., Kassiou, M., McGregor, I., Kevin, R., Hibbs, D., Jorgensen, W., Banister, S., Cairns, E., Ametovski, A. (2024). Structure-Activity Relationships, Deuteration, and Fluorination of Synthetic Cannabinoid Receptor Agonists Related to AKB48, 5F-AKB-48, and AFUBIATA. ACS Chemical Neuroscience, 15(11), 2160-2181. [More Information]
• Sparkes, E., Santiago, M., Hibbs, D., Banister, S., Ametovski, A., Cairns, E., Markham, J., Boyd, R., Udoh, M., Gordon, R., Walker, K., Dane, C., Kevin, R., et al (2024). Synthesis and functional evaluation of proteinogenic amino acid-derived synthetic cannabinoid receptor agonists related to MPP-5F-PICA, MMB-5F-PICA, and MDMB-5F-PICA. RSC Medicinal Chemistry, 15(6), 2063-2079. [More Information]

2023

• Webb, H., Finlay, D., Chen, S., Vernall, A., Sparkes, E., Banister, S., Rosengren, R., Glass, M. (2023). Characterisation of AMB-FUBINACA metabolism and CB1-mediated activity of its acid metabolite. Forensic Toxicology, 41(1), 114-125. [More Information]
• Janssens, L., Ametovski, A., Sparkes, E., Boyd, R., Lai, F., Maloney, C., Rhook, D., Gerona, R., Connolly, M., Liu, H., Hibbs, D., Cairns, E., Banister, S., et al (2023). Comprehensive Characterization of a Systematic Library of Alkyl and Alicyclic Synthetic Cannabinoids Related to CUMYL-PICA, CUMYL-BUTICA, CUMYL-CBMICA, and CUMYL-PINACA. ACS Chemical Neuroscience, 14(1), 35-52. [More Information]

2022

• Markham, J., Sparkes, E., Boyd, R., Chen, S., Manning, J., Finlay, D., Lai, F., McGregor, E., Maloney, C., Gerona, R., McGregor, I., Hibbs, D., Kevin, R., Banister, S., et al (2022). Defining Steric Requirements at CB1 and CB2 Cannabinoid Receptors Using Synthetic Cannabinoid Receptor Agonists 5F-AB-PINACA, 5F-ADB-PINACA, PX-1, PX-2, NNL-1, and Their Analogues. ACS Chemical Neuroscience, 13(8), 1281-1295. [More Information]
• Sparkes, E., Cairns, E., Kevin, R., Lai, F., Grafinger, K., Chen, S., Deventer, M., Ellison, R., Boyd, R., Martin, L., McGregor, I., Hibbs, D., Banister, S., et al (2022). Structure-activity relationships of valine, tert -leucine, and phenylalanine amino acid-derived synthetic cannabinoid receptor agonists related to ADB-BUTINACA, APP-BUTINACA, and ADB-P7AICA. RSC Medicinal Chemistry, 13(2), 156-174. [More Information]
• Sparkes, E., Boyd, R., Chen, S., Markham, J., Luo, J., Foyzun, T., Zaman, H., Fletcher, C., Ellison, R., McGregor, I., Lai, F., Hibbs, D., Cairns, E., Ametovski, A., Banister, S., et al (2022). Synthesis and pharmacological evaluation of newly detected synthetic cannabinoid receptor agonists AB-4CN-BUTICA, MMB-4CN-BUTINACA, MDMB-4F-BUTICA, MDMB-4F-BUTINACA and their analogs. Frontiers in Psychiatry, 13. [More Information]

2021

• Grafinger, K., Cannaert, A., Ametovski, A., Sparkes, E., Cairns, E., Banister, S., Auwärter, V., Stove, C. (2021). Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB₁ receptor activation assays—Part II: Structure activity relationship assessment via a ƒÀ-arrestin recruitment assay. Drug Testing and Analysis, 13(7), 1402-1411. [More Information]
• Grafinger, K., Vandeputte, M., Cannaert, A., Ametovski, A., Sparkes, E., Cairns, E., Juchli, P., Haschimi, B., Pulver, B., Banister, S., et al (2021). Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays. Part III: The G protein pathway and critical comparison of different assays. Drug Testing and Analysis, 13(7), 1412-1429. [More Information]
• Pike, E., Grafinger, K., Cannaert, A., Ametovski, A., Luo, J., Sparkes, E., Cairns, E., Ellison, R., Gerona, R., Stove, C., Banister, S., et al (2021). Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays: Part I—Synthesis, analytical characterization, and binding affinity for human CB1 receptors. Drug Testing and Analysis, 13(7), 1383-1401. [More Information]

2020

• Ametovski, A., MacDonald, C., Manning, J., Syed Haneef, S., Santiago, M., Martin, L., Sparkes, E., Reckers, A., Gerona, R., Connor, M., Banister, S., et al (2020). Exploring Stereochemical and Conformational Requirements at Cannabinoid Receptors for Synthetic Cannabinoids Related to SDB-006, 5F-SDB-006, CUMYL-PICA, and 5F-CUMYL-PICA. ACS Chemical Neuroscience, 11(21), 3672-3682. [More Information]
• Cannaert, A., Sparkes, E., Pike, E., Luo, J., Fang, A., Kevin, R., Ellison, R., Gerona, R., Banister, S., Stove, C. (2020). Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA. ACS Chemical Neuroscience, 11(24), 4434-4446. [More Information]