Professor Fabienne Brilot-Turville
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Professor Fabienne Brilot-Turville

Principal Research Fellow
School of Medical Sciences
Brain and Mind Centre
University of Sydney
Brain Autoimmunity Group
Kids Research, Kids Neuroscience Centre
the Children's Hospital at Westmead
Professor Fabienne Brilot-Turville

Fabienne Brilot-Turville is a Principal Research Fellow and Professor of Neuroimmunologyat the University of Sydney. She heads the Brain Autoimmunity laboratory within Kids Neuroscience Centre at Kids Research at the Children's Hospital at Westmead. Her research interests are the detection and role of autoantibodies in brain immune-mediated diseases including brain demyelination and movement disorders. Fabienne also heads the Brain Autoantibody Testing Referral Centre which provides autoantibody testing for diagnosis purposes.

Reproductive, Maternal and Child Health, Neurosciences and Mental Health, Lifespan
Project titleResearch student
Defining the Expanding Clinical Spectrum of Myelin Oligodendrocyte Glycoprotein Antibody DiseaseNiroshan JEYAKUMAR

Publications

Book Chapters

  • Brilot-Turville, F. (2010). Inflammation and Autoimmunity: A Nervous System Perspective. In Russell C Dale, Angela Vincent (Eds.), Inflammatory and Autoimmune Disorders of the Nervous System in Children, (pp. 1-13). London: Mac Keith Press.
  • Brilot-Turville, F., Geenen, V., Hober, D. (2006). Coxsackievirus B4 and Type I Diabetes. In Sabine Thebault (Eds.), Progress in Virus Research, (pp. 169-190). United States: Nova Science Publishers.
  • Brilot-Turville, F., Geenen, V., Hober, D. (2005). Coxsackie B4 and type 1 diabetes. In Thebault S (Eds.), Progress in Virus Research, (pp. 169-189). United States: Nova Science Publishers.

Journals

  • Amin, M., Al-iedani, O., Lea, R., Brilot-Turville, F., Maltby, V., Lechner-Scott, J. (2024). A longitudinal analysis of brain volume changes in myelin oligodendrocyte glycoprotein antibody-associated disease. Journal of Neuroimaging, 34(1), 78-85. [More Information]
  • Arnett, S., Prain, K., Ramanathan, S., Abernethy, D., Brilot-Turville, F., Broadley, S. (2024). Long-term outcomes of ADEM-like and tumefactive presentations of CNS demyelination: a case-comparison analysis. Journal of Neurology. [More Information]
  • Trewin, B., Dale, R., Qiu, J., Chu, M., Jeyakumar, N., Cruz, F., Andersen, J., Siriratnam, P., Ma, K., Hardy, T., Barnett, M., Reddel, S., Brilot-Turville, F., Ramanathan, S., et al (2024). Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse. Journal of Neurology, Neurosurgery and Psychiatry, 95(11), 1054-1063. [More Information]

2024

  • Amin, M., Al-iedani, O., Lea, R., Brilot-Turville, F., Maltby, V., Lechner-Scott, J. (2024). A longitudinal analysis of brain volume changes in myelin oligodendrocyte glycoprotein antibody-associated disease. Journal of Neuroimaging, 34(1), 78-85. [More Information]
  • Arnett, S., Prain, K., Ramanathan, S., Abernethy, D., Brilot-Turville, F., Broadley, S. (2024). Long-term outcomes of ADEM-like and tumefactive presentations of CNS demyelination: a case-comparison analysis. Journal of Neurology. [More Information]
  • Trewin, B., Dale, R., Qiu, J., Chu, M., Jeyakumar, N., Cruz, F., Andersen, J., Siriratnam, P., Ma, K., Hardy, T., Barnett, M., Reddel, S., Brilot-Turville, F., Ramanathan, S., et al (2024). Oral corticosteroid dosage and taper duration at onset in myelin oligodendrocyte glycoprotein antibody-associated disease influences time to first relapse. Journal of Neurology, Neurosurgery and Psychiatry, 95(11), 1054-1063. [More Information]

2023

  • Banwell, B., Bennett, J., Marignier, R., Kim, H., Brilot-Turville, F., Flanagan, E., Ramanathan, S., Waters, P., Tenembaum, S., Graves, J., et al (2023). Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria. The Lancet Neurology, 22(3), 268-282. [More Information]
  • Spatola, M., Chuquisana, O., Jung, W., Lopez, J., Wendel, E., Ramanathan, S., Keller, C., Hahn, T., Meinl, E., Reindl, M., Dale, R., Wiendl, H., Brilot-Turville, F., et al (2023). Humoral signatures of MOG-antibody-associated disease track with age and disease activity. Cell Reports Medicine, 4(2). [More Information]
  • Pillay, A., Moran, L., Jadhav, A., Sterling, K., Lai, C., Vitagliano, T., Aggarwal, A., Catchpoole, D., Wood, N., Giang Phan, T., Nanan, R., Britton, P., Brilot-Turville, F., Burrell, R., et al (2023). Infection and Vaccine Induced Spike Antibody Responses Against SARS-CoV-2 Variants of Concern in COVID-19-Naïve Children and Adults. Journal of Clinical Immunology, 43(8), 1706-1723. [More Information]

2022

  • Han, V., Jones, H., Patel, S., Mohammad, S., Hofer, M., Alshammery, S., Maple-Brown, E., Gold, W., Brilot-Turville, F., Dale, R. (2022). Emerging evidence of Toll-like receptors as a putative pathway linking maternal inflammation and neurodevelopmental disorders in human offspring: a systematic review. Brain, Behavior, and Immunity, 99, 91-105. [More Information]
  • Seneviratne, S., Marriott, M., Ramanathan, S., Yeh, W., Brilot-Turville, F., Butzkueven, H., Monif, M. (2022). Failure of alemtuzumab therapy in three patients with MOG antibody associated disease. BMC Neurology, 22(1), 84. [More Information]
  • Phetsouphanh, C., Khoo, W., Jackson, K., Klemm, V., Howe, A., Aggarwal, A., Akerman, A., Milogiannakis, V., Stella, A., Rouet, R., Brilot-Turville, F., et al (2022). High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells. Frontiers in Immunology, 13. [More Information]

2021

  • Wienholt, L., Kane, A., Adelstein, S., Richardson, A., Kothur, K., Brilot-Turville, F., Dale, R. (2021). Cerebrospinal fluid free light chain quantitation is a specific biomarker for inflammatory neurological disorders in a paediatric patient cohort. Pathology, 53(6), 753-758. [More Information]
  • Keller, C., Lopez, J., Wendel, E., Ramanathan, S., Gross, C., Klotz, L., Reindl, M., Dale, R., Wiendl, H., Rostasy, K., Brilot-Turville, F., et al (2021). Complement Activation Is a Prominent Feature of MOGAD. Annals of Neurology, 90(6), 976-982. [More Information]
  • Ramanathan, S., Tseng, M., Davies, A., Uy, C., Paneva, S., Mgbachi, V., Michael, S., Varley, J., Binks, S., Themistocleous, A., Brilot-Turville, F., Dale, R., et al (2021). Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons. Annals of Neurology, 90(4), 683-690. [More Information]

2020

  • Tea, F., Pilli, D., Ramanathan, S., Lopez, J., Merheb, V., Lee, F., Zou, A., Liyanage, G., Bassett, C., Thomsen, S., Reddel, S., Barnett, M., Brown, D., Dale, R., Brilot-Turville, F. (2020). Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry. Frontiers in Immunology, 11, 119. [More Information]
  • Reindl, M., Schanda, K., Woodhall, M., Tea, F., Ramanathan, S., Sagen, J., Fryer, J., Mills, J., Teegen, B., Mindorf, S., Dale, R., Brilot-Turville, F., et al (2020). International multicenter examination of MOG antibody assays. Neurology: Neuroimmunology and Neuroinflammation, 7(2), 1-12. [More Information]
  • Dahan, A., Brilot, F., Leventer, R., Kornberg, A., Dale, R., Yiu, E. (2020). Neuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort. Journal of Child Neurology, 35(4), 291-296. [More Information]

2019

  • Prain, K., Woodhall, M., Vincent, A., Ramanathan, S., Barnett, M., Bundell, C., Parratt, J., Silvestrini, R., Bukhari, W., Brilot-Turville, F., et al (2019). AQP4 Antibody Assay Sensitivity Comparison in the Era of the 2015 Diagnostic Criteria for NMOSD. Frontiers in Neurology, 10, 1-7. [More Information]
  • Tea, F., Lopez, J., Ramanathan, S., Merheb, V., Lee, F., Zou, A., Pilli, D., Patrick, E., van der Walt, A., Monif, M., Tantsis, E., Fraser, C., Reddel, S., Barnett, M., Brown, D., Dale, R., Brilot-Turville, F., et al (2019). Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination. Acta Neuropathologica Communications, 7(1), 1-22. [More Information]
  • Ramanathan, S., O'Grady, G., Malone, S., Spooner, C., Brown, D., Gill, D., Brilot, F., Dale, R. (2019). Isolated seizures during the first episode of relapsing myelin oligodendrocyte glycoprotein antibody-associated demyelination in children. Developmental Medicine and Child Neurology, 61(5), 610-614. [More Information]

2018

  • Ramanathan, S., Mohammad, S., Tantsis, E., Nguyen, T., Merheb, V., Fung, V., White, O., Broadley, S., Lechner-Scott, J., Vucic, S., Henderson, A., Barnett, M., Reddel, S., Brilot-Turville, F., Dale, R. (2018). Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination. Journal of Neurology, Neurosurgery and Psychiatry, 89(2), 127-137. [More Information]
  • Brilot-Turville, F. (2018). Relapsing acute disseminated encephalomyelitis followed by optic neuritis in children; a clinical entity associated with anti-MOG antibody. European Journal of Neurology, 25(8), 1003-1004. [More Information]

2017

  • Weissert, R., Brilot-Turville, F. (2017). Editorial: Induction of central nervous system disease by the adaptive immune response. Frontiers in Immunology, 8(1218), 1-2. [More Information]
  • Pilli, D., Zou, A., Tea, F., Dale, R., Brilot-Turville, F. (2017). Expanding Role of T Cells in Human Autoimmune Diseases of the Central Nervous System. Frontiers in Immunology, 8, 1-17. [More Information]
  • Chen, K., Brilot-Turville, F., Dale, R., Lafferty, A., Andrews, P. (2017). Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description. European Journal of Paediatric Neurology, 21(6), 898-901. [More Information]

2016

  • Ramanathan, S., Dale, R., Brilot-Turville, F. (2016). Anti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmunity Reviews, 15(4), 307-324. [More Information]
  • Ramanathan, S., Sato, S., Matsushita, T., Masaki, K., Yamasaki, R., Dale, R., Kira, J., Brilot-Turville, F. (2016). Antibodies to myelin oligodendrocyte glycoprotein are uncommon in Japanese opticospinal multiple sclerosis. Multiple Sclerosis Journal, 22(1), 127-128. [More Information]
  • Kothur, K., Wienholt, L., Tantsis, E., Earl, J., Bandodkar, S., Prelog, K., Tea, F., Ramanathan, S., Brilot-Turville, F., Dale, R. (2016). B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination. PloS One, 11(2), 1-16. [More Information]

2015

  • Pathmanandavel, K., Starling, J., Merheb, V., Ramanathan, S., Sinmaz, N., Dale, R., Brilot-Turville, F. (2015). Antibodies to Surface Dopamine-2 Receptor and N-Methyl-D-Aspartate Receptor in the First Episode of Acute Psychosis in Children. Biological Psychiatry, 77(6), 537-547. [More Information]
  • Sinmaz, N., Amatoury, M., Merheb, V., Ramanathan, S., Dale, R., Brilot-Turville, F. (2015). Autoantibodies in movement and psychiatric disorders: Updated concepts in detection methods, pathogenicity, and CNS entry. Annals of the New York Academy of Sciences, 1351 (1), 22-38. [More Information]
  • Mohammad, S., Nosadini, M., Brilot-Turville, F., Dale, R. (2015). Autoimmune Movement Disorders in Children: Clinical Characteristics and Therapeutic Considerations. Journal of Pediatric Neurology, 13(4), 144-154. [More Information]

2014

  • Dale, R., Tantsis, E., Merheb, V., Kumaran, R., Sinmaz, N., Pathmanandavel, K., Ramanathan, S., Booth, D., Wienholt, L., Prelog, K., Mathey, E., Brilot-Turville, F., et al (2014). Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton. Neurology: Neuroimmunology and Neuroinflammation, 2014 (1), 1-10. [More Information]
  • Ramanathan, S., Reddel, S., Henderson, A., Parratt, J., Barnett, M., Gatt, P., Merheb, V., Kumaran, R., Pathmanandavel, K., Sinmaz, N., Yiannikas, K., Vucic, S., Stewart, G., Booth, D., Dale, R., Brilot-Turville, F., et al (2014). Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis. Neurology: Neuroimmunology and Neuroinflammation, 1(4), 1-12. [More Information]
  • Mohammad, S., Wallace, G., Ramanathan, S., Brilot-Turville, F., Dale, R. (2014). Antipsychotic-induced akathisia and neuroleptic malignant syndrome in anti-NMDAR encephalitis. Annals of Clinical Psychiatry, 26(4), 297-298.

2013

  • Pathmanandavel, K., Starling, J., Dale, R., Brilot, F. (2013). Autoantibodies and the immune hypothesis in psychotic brain diseases: challenges and perspectives. Clinical & Developmental Immunology, 2013, 1-10. [More Information]
  • Suleiman, J., Wright, S., Gill, D., Brilot-Turville, F., Waters, P., Peacock, K., Procopis, P., Nibber, A., Vincent, A., Dale, R., et al (2013). Autoantibodies to neuronal antigens in children with new-onset seizures classified according to the revised ILAE organization of seizures and epilepsies. Epilepsia, 54(12), 2091-2100. [More Information]
  • Mohammad, S., Ramanathan, S., Brilot-Turville, F., Dale, R. (2013). Autoantibody-Associated Movement Disorders. Neuropediatrics, 44(6), 336-345. [More Information]

2012

  • Dale, R., Merheb, V., Pillai, S., Wang, D., Cantrill, L., Murphy, T., Ben-Pazi, H., Varadkar, S., Aumann, T., Horne, M., Brilot-Turville, F., et al (2012). Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders. Brain, 135(Pt 11), 3453-3468. [More Information]
  • Dale, R., Banwell, B., Bar-Or, A., Brilot-Turville, F. (2012). Autoantibodies against aquaporin-4 and myelin oligodendrocyte glycoprotein in paediatric CNS demyelination: Recent developments and future directions. Multiple Sclerosis and Related Disorders, 1(3), 116-122. [More Information]
  • Dale, R., Brilot-Turville, F. (2012). Autoimmune Basal Ganglia disorders. Journal of Child Neurology, 27(11), 1470-1481. [More Information]

2011

  • Pröbstel, A., Dornmair, K., Bittner, R., Sperl, P., Jenne, D., Magalhaes, S., Villalobos, A., Breithaupt, C., WeWeissert, R., Jacob, U., Brilot-Turville, F., Tantsis, E., Dale, R., et al (2011). Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Neurology, 77(6), 580-588. [More Information]
  • Dale, R., Yin, K., Ding, A., Merheb, V., Varadkhar, S., McKay, D., Singh-Grewal, D., Brilot-Turville, F. (2011). Antibody binding to neuronal surface in movement disorders associated with lupus and antiphospholipid antibodies. Developmental Medicine and Child Neurology, 53(6), 522-528. [More Information]
  • Brilot-Turville, F., Merheb, V., Ding, A., Murphy, T., Dale, R. (2011). Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome. Neurology, 76(17), 1508-1513. [More Information]

2010

  • Selter, R., Brilot-Turville, F., Grummel, V., Kraus, V., Cepok, S., Dale, R., Hemmer, B. (2010). Antibody responses to EBV and native MOG in pediatric inflammatory demyelinating CNS diseases. Neurology, 74(21), 1711-1715. [More Information]
  • Dale, R., Brilot-Turville, F. (2010). Biomarkers of inflammatory and auto-immune central nervous system disorders. Current Opinion in Pediatrics, 22(6), 718-725. [More Information]
  • Brilot-Turville, F. (2010). Inflammation and Autoimmunity: A Nervous System Perspective. In Russell C Dale, Angela Vincent (Eds.), Inflammatory and Autoimmune Disorders of the Nervous System in Children, (pp. 1-13). London: Mac Keith Press.

2009

  • Brilot-Turville, F., Dale, R., Selter, R., Grummel, V., Reddy Kalluri, S., Aslam, M., Busch, V., Zhou, D., Cepok, S., Hemmer, B. (2009). Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease. Annals of Neurology, 66(6), 833-842. [More Information]
  • Dale, R., Brilot-Turville, F., Fagan, E., Earl, J. (2009). Cerebrospinal fluid neopterin in paediatric neurology: a marker of active central nervous system inflammation. Developmental Medicine and Child Neurology, 51(4), 317-323. [More Information]
  • Dale, R., Irani, S., Brilot-Turville, F., Pillai, S., Webster, R., Gill, D., Lang, B., Vincent, A. (2009). N-methyl-D-aspartate receptor antibodies in pediatric dyskinetic encephalitis lethargica. Annals of Neurology, 66(5), 704-709. [More Information]

2008

  • Brilot-Turville, F., Jaidane, H., Geenen, V., Hober, D. (2008). Coxsackievirus B4 Infection of Murine Foetal Thymus Organ Cultures. Journal of Medical Virology, 80(4), 659-660. [More Information]
  • Gurer, C., Strowig, T., Brilot-Turville, F., Pack, M., Trumpfheller, C., Arrey, F., Park, C., Steinman, R., Munz, C. (2008). Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses. Blood, 112(4), 1231-1239. [More Information]
  • Strowig, T., Brilot-Turville, F., Arrey, F., Bougras, G., Thomas, D., Muller, W., Munz, C. (2008). Tonsilar NK cells restrict B cell transformation by the Epstein-Barr virus via IFN-γ. PLoS Pathogens, 4(2), e27 - 1-e27 - 13. [More Information]

2007

  • Brilot-Turville, F., Strowig, T., Roberts, S., Arrey, F., Munz, C. (2007). NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Rα. Journal of Clinical Investigation, 117(11), 3316-3329. [More Information]

2006

  • Brilot-Turville, F., Geenen, V., Hober, D. (2006). Coxsackievirus B4 and Type I Diabetes. In Sabine Thebault (Eds.), Progress in Virus Research, (pp. 169-190). United States: Nova Science Publishers.
  • Brilot-Turville, F., Strowig, T., Munz, C. (2006). NK cells interactions with dendritic cells shape innate and adaptive immunity. Frontiers in Bioscience, 13, 6443-6454. [More Information]
  • Strowig, T., Brilot-Turville, F., Munz, C. (2006). Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. Journal of Immunology, 180(12), 7785-7791. [More Information]

2005

  • Brilot-Turville, F., Geenen, V., Hober, D. (2005). Coxsackie B4 and type 1 diabetes. In Thebault S (Eds.), Progress in Virus Research, (pp. 169-189). United States: Nova Science Publishers.
  • Hansenne, I., Rasier, G., Pequeux, C., Brilot-Turville, F., Renard, C., Breton, C., Greimers, R., Legros, J., Geenen, V., Martens, H. (2005). Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus network. Journal of Neuroimmunology, 158(1-2), 67-75. [More Information]

2004

  • Brilot-Turville, F., Geenen, V., Hober, D., Stoddart, C. (2004). Coxsackievirus B4 infection of human fetal thymus cells. Journal of Virology, 78(18), 9854-9861. [More Information]
  • Sandberg, J., Stoddart, C., Brilot-Turville, F., Jordan, K., Nixon, D. (2004). Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7. Proceedings of the National Academy of Sciences of the United States of America, 101(18), 7058-7063. [More Information]

Selected Grants

2023

  • Rewarding Research 2024, Brilot-Turville F, Faculty of Medicine and Health/FMH Rewarding Research Success
  • MOG antibody epitope as a clinical biomarker for relapsing disease in pediatric and adult MOGAD, Brilot-Turville F, Ramanathan S, Dale R, The MOG Project/Apollo Grant

2022

  • Understanding the autoimmune response against the brain to improve diagnosis and therapy of neuroimmunological disorders, Brilot-Turville F, National Health and Medical Research Council (NHMRC)/Investigator Grant
  • antiCD20 treatment to rationalise the use of IV/SC-IG in CIDP, Brown D, Brilot-Turville F, Reed J, Ramanathan S, Kelleher A, Kiernan M, Vucic S, Department of Health and Aged Care (Federal)/MRFF - PPHRI - 2021 Optimising the Clinical Use of Immunoglobulins
  • COVID-19 vaccine immunogenicity in Australian people with multiple sclerosis, Brilot-Turville F, Multiple Sclerosis Australia/Research Support