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Dr Gabrielle Pennings
Research Fellow
ANZAC Research Institute, Concord Clinical School
ANZAC Research Institute, Concord Clinical School
Dr Pennings is currently a postdoctoral researcher, under the supervision of Prof Len Kritharides, in the Vascular Biology Group at the ANZAC Research Institute and holds an affiliate position of Research Fellow at the University of Sydney. Her main areas of interest include platelet and leukocyte biology particularly the role of platelets in cardiovascular disease. She completed her PhD under the supervision of Prof John Fletcher and Dr Heather Medbury at Westmead Hospital and received the John Loewenthal Medal for outstanding research in the Department of Surgery at the University of Sydney. Her current work is at the interface of platelets and inflammation and the impact on cardiovascular disease. She is also interested in the effect of remote ischaemic preconditioning on platelets in cardiovascular disease and the role of ageing on platelet activity.
Platelet and Leukocyte Biology
Inflammation
Ageing
Remote Ischaemic Preconditioning (RIPC)
Cardiovascular Disease
- Finalist in the Concord Repatriation General Hospital Early Career Research Award 2019
- Finalist in the Concord Repatriation General Hospital Early Career Research Award 2016 and recipient of the “Highly Commended” Award
- Recipient of the “Sydney Medical School/Balnaves Foundation Kickstart Grant 2015” ($25000)
- Travel Award from ASTH to attend the HAA 2012 in Melbourne ($1000)
- Awarded the ‘Best Postdoctoral Poster Prize’ at the 18th Australian Vascular Biology Society 2011
- John Loewenthal Medal recipient (Department of Surgery, The University of Sydney for my PhD Studies)
- Travel Award to attend the 15th Annual Conference Australian Society for Biomaterials 2005.
- Student Award 2004 from the Australian Society for Biomaterials
- Travel Award to attend the 7th World Biomaterials Congress in 2004
- Successful applicant for Charitable Trust Foundation to fund International Conference Travel (to Karuizawa, Japan)
- Runner-up for Student Award at 12th Annual Conference of the Australian Society for Biomaterials, ANU, Canberra, 2002
- Successful Applicant for Stipend Enhancement Grant 2002-2004 awarded by the Westmead Millennium Foundation
- Successful Applicant for Australian Postgraduate Award 2001 awarded by the Australian Government
Obesity, Diabetes and Cardiovascular Disease, Healthy Ageing
Publications
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Journals
- Pennings, G., Reddel, C., Chen, V., Gnanenthiran, S., Kritharides, L. (2023). Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease. Frontiers in Cardovascular Medicine, 9. [More Information]
- Reddel, C., Pennings, G., Chen, V., Gnanenthiran, S., Kritharides, L. (2022). Colchicine as a Modulator of Platelet Function: A Systematic Review. Seminars in Thrombosis and Hemostasis, 48(5), 552-567. [More Information]
- Gnanenthiran, S., Pennings, G., Reddel, C., Campbell, H., Kockx, M., Hamilton, J., Chen, V., Kritharides, L. (2022). Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists with Platelet PAR (Protease-Activated Receptor)-1 and PAR-4-Mediated Thrombin Resistance. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(8), 960-972. [More Information]
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2023
- Pennings, G., Reddel, C., Chen, V., Gnanenthiran, S., Kritharides, L. (2023). Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease. Frontiers in Cardovascular Medicine, 9. [More Information]
2022
- Reddel, C., Pennings, G., Chen, V., Gnanenthiran, S., Kritharides, L. (2022). Colchicine as a Modulator of Platelet Function: A Systematic Review. Seminars in Thrombosis and Hemostasis, 48(5), 552-567. [More Information]
- Gnanenthiran, S., Pennings, G., Reddel, C., Campbell, H., Kockx, M., Hamilton, J., Chen, V., Kritharides, L. (2022). Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists with Platelet PAR (Protease-Activated Receptor)-1 and PAR-4-Mediated Thrombin Resistance. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(8), 960-972. [More Information]
- Pennings, G., Reddel, C., Traini, M., Lam, M., Kockx, M., Chen, V., Kritharides, L. (2022). Rapid Release of Interleukin-1β from Human Platelets Is Independent of NLRP3 and Caspase. Thrombosis and Haemostasis, 122(4), 517-528. [More Information]
2021
- Reddel, C., Pennings, G., Lau, J., Chen, V., Kritharides, L. (2021). Circulating platelet-derived extracellular vesicles are decreased after remote ischemic preconditioning in patients with coronary disease: A randomized controlled trial. Journal of Thrombosis and Haemostasis, 19(10), 2605-2611. [More Information]
- Pennings, G., Reddel, C., Traini, M., Campbell, H., Chen, V., Kritharides, L. (2021). Colchicine inhibits ROS generation in response to glycoprotein VI stimulation. Scientific Reports, 11(1), 11965. [More Information]
2020
- Lau, J., Pennings, G., Reddel, C., Campbell, H., Liang, H., Traini, M., Gardiner, E., Yong, A., Chen, V., Kritharides, L. (2020). Remote ischemic preconditioning inhibits platelet αIIbβ3 activation in coronary artery disease patients receiving dual antiplatelet therapy: A randomized trial. Journal of Thrombosis and Haemostasis, 18(5), 1221-1232. [More Information]
2018
- Pasalic, L., Wing-Luna, E., Lau, J., Campbell, H., Pennings, G., Lau, E., Connor, D., Liang, H., Muller, D., Kritharides, L., Hogg, P., Chen, V. (2018). Novel assay demonstrates that coronary artery disease patients have heightened procoagulant platelet response. Journal of Thrombosis and Haemostasis, 16(6), 1198-1210. [More Information]
- Reddel, C., Pennings, G., Curnow, J., Chen, V., Kritharides, L. (2018). Procoagulant Effects of Low-Level Platelet Activation and Its Inhibition by Colchicine. Thrombosis and Haemostasis, 118(4), 723-733. [More Information]
2017
- Lau, J., Pennings, G., Yong, A., Kritharides, L. (2017). Cardiac Remote Ischaemic Preconditioning: Mechanistic and Clinical Considerations. Heart, Lung, and Circulation, 26(6), 545-553. [More Information]
- Pasalic, L., Pennings, G., Connor, D., Campbell, H., Kritharides, L., Chen, V. (2017). Flow Cytometry Protocols for Assessment of Platelet Function in Whole Blood. Methods in Molecular Biology, 1646, 369-389. [More Information]
2015
- Chow, V., Reddel, C., Pennings, G., Scott, E., Pasqualon, T., Ng, A., Yeoh, T., Curnow, J., Kritharides, L. (2015). Global hypercoagulability in patients with schizophrenia receiving long-term antipsychotic therapy. Schizophrenia Research, 162(1-3), 175-182. [More Information]
- Chow, V., Reddel, C., Pennings, G., Chung, T., Ng, A., Curnow, J., Kritharides, L. (2015). Persistent global hypercoagulability in long-term survivors of acute pulmonary embolism. Blood Coagulation and Fibrinolysis, 26(5), 537-544. [More Information]
2014
- Pennings, G., Kritharides, L. (2014). CD147 in Cardiovascular Disease and Thrombosis. Seminars in Thrombosis and Hemostasis, 40(7), 747-755. [More Information]
- Pennings, G., Yong, A., Wong, C., Al-Tamimi, M., Gardiner, E., Andrews, R., Kritharides, L. (2014). Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma. Platelets, 25(8), 639-642. [More Information]
- Pennings, G., Siegwald, J., Yong, A., Kritharides, L., Lowe, H. (2014). Intravascular blood sampling using the thrombuster II catheter does not cause artifactual platelet activation. Journal of Thrombosis and Thrombolysis, 37(3), 326-330. [More Information]
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2013
- Reddel, C., Curnow, J., Voitl, J., Rosenov, A., Pennings, G., Morel-Kopp, M., Brieger, D. (2013). Detection of hypofibrinolysis in stable coronary artery disease using the overall haemostatic potential assay. Thrombosis Research, 131(5), 457-462. [More Information]
- Yong, A., Pennings, G., Wong, C., Javadzadegan, A., Brieger, D., Lowe, H., Qi, M., Behnia, M., Krilis, S., Kritharides, L. (2013). Intracoronary upregulation of platelet extracellular matrix metalloproteinase inducer (CD147) in coronary disease. International Journal of Cardiology, 166(3), 716-721. [More Information]
- Edelman, J., Fung, Y., Pennings, G., Reddel, C., Bannon, P., Bayfield, M., Kritharides, L., Fraser, J., Vallely, M. (2013). Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology. Shock, 39(2), 149-154. [More Information]
2012
- Al-Tamimi, M., Tan, C., Qiao, J., Pennings, G., Javadzadegan, A., Yong, A., Arthur, J., Davis, A., Jing, J., Mu, F., Ward, C., Kritharides, L., et al (2012). Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood, 119(18), 4311-4320. [More Information]
2011
- Yong, A., Pennings, G., Chang, M., Hamzah, A., Chung, T., Qi, M., Brieger, D., Behnia, M., Krilis, S., Ng, M., Lowe, H., Kritharides, L. (2011). Intracoronary Shear-Related Up-Regulation of Platelet P-Selectin and Platelet-Monocyte Aggregation Despite the Use of Aspirin and Clopidogrel. Blood, 117(1), 11-20. [More Information]
2006
- Varcoe, R., Mikhail, M., Guiffre, A., Pennings, G., Vicaretti, M., Hawthorne, W., Fletcher, J., Medbury, H. (2006). The role of the fibrocyte in intimal hyperplasia. Journal of Thrombosis and Haemostasis, 4(5), 1125-1133. [More Information]
Selected Grants
2024
- How do platelet blood cells change with age in people with heart disease?, Kritharides L, Gnanenthiran S, Chen V, Pennings G, National Heart Foundation of Australia/Vanguard Grant