People_

Professor Hong Zhou

Senior Principal Research Fellow
School of Medical Sciences
ANZAC Research Institute

Phone

02 97679164

Fax

02 97679101

Email

h.zhou@sydney.edu.au

Resume

Curriculum vitae

Biographical details

Professor Hong Zhou received her Ph.D from the University of Melbourne. She has considerable expertise in the cell and molecular biology of musculoskeletal tissues, glucocorticoid signalling, systemic fuel metabolism, and animal models of bone and joint pathology. She has extensive skills and experience in the use and analysis of animal models of normal and abnormal bone metabolism, skeletal development, bone and cartilage biology, autoimmune arthritis, surgically induced osteoarthritis, fracture healing and cancer, including genetically modified animal models. Since 2004, she worked continuously and successfully on questions of glucocorticoid and other steroids action in bone and her research was supported by 10NHMRC project and 2 Idea grants (CIA on 6 and CIB on 5, CIC on 1).Over the course of her career, she has published more then 130 scientific reports, many of which appeared in top-ranking journals such as J Clin Invest,J Exp Med, PNAS,Development,Arthritis Rheum,JBMR, Diabetes, Cancer Res,JBC, Bone Research and JBMRwith7,712citations.Her current h-index is 53(Scopus March 2024). She has been the laboratory head since 2008 andhas supervised and supervising 10 PhD students, 3 international exchanging PhD students from China sponsored by CSC scholarship, 1 MPhil student, 1 Honours student, 16 doctoral students from Humboldt University Berlin, Germany (an ongoing collaborative research program), and 12 Summer Research Scholarship students.

Research interests

Glucocorticoid action on bone and joints, bone regulated systemic metabolism, osteoarthritis.

Current projects

Effects of Exogenous Glucocorticoids on Bone, Fat and Energy Metabolism

S Gasparini, H Henneicke, C Jørgensen, M Swarbrick, H Bräuner-Osborne, H Zhou, MJ Seibel

Interaction of Exogenous Glucocorticoids and Sex Steroids in Metabolic Dysfunction

S Gasparini, H Henneicke,S Kim, D Handelsman,H Zhou, MJ Seibel

Endogenous Glucocorticoids and Ageing

H Henneicke, S Kim, M Swarbrick, P Lee, M Cooper, MJ Seibel, H Zhou

Endogenous Glucocorticoids and Diet-induced Bone, Fat and Metabolic Dysregulation

S Kim, H Henneicke, M Swarbrick, MJ Seibel, H Zhou

Endogenous Glucocorticoids in Immune Arthritis

J Tu, M Cooper, C Little, F Buttgereit, MJ Seibel, H Zhou

Preventing the Spread of Malignant Tumours to Bone

Y Zheng, C Fong-Yee, H Zhou, MJ Seibel

The role of the Vitamin D receptor in malignant bone disease

Y Zheng, K Horas, C Fong-Yee, H Zhou, MJ Seibel

Themes

Obesity, Diabetes and Cardiovascular Disease, Cancer, Healthy Ageing

Keywords

Arthritis, Cancer, Osteoporosis, Osteoarthritis

Approaches

Animal Models, Cellular Signalling

International links

China	(The First Hospital Affiliated to Nanjing Medical University) collabrate with Professor Guoxian Ding to investigate the effects of glucocorticoid on body fat accumulation via suppressing the browning of white adipose tissue
Denmark	(Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen) NHMRC project grant on role of osteocalcin in fuel metabolism
Germany	(Humboldt University Berlin,) collaborate with Prof. Frank Buttgereit-Role of glucocorticoids in autoimmune arthritis
Germany	(Institute of General Zoology and Endocrinology University of Ulm, Ulm, ) the role of glucocorticoid in autoimmune arthritis using glucocorticoid receptor conditional knock out mice
United Kingdom	(University of Birmingham) Collaborate with Prof Paul Stewart and Dr Mark Cooper - Role of 11ß-HSD1 in inflammatory arthritis
United States	(University of Rochester, NY.) Co-investigator Prof. Di Chen-HNMRC Project Grant on How Osteoblasts Control Mesenchymal Progenitors.

Publications

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Book Chapters

Zheng, Y., Seibel, M., Zhou, H. (2011). Methods in Bone Biology: Cancer and Bone. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 83-91). London: Springer. [More Information]
Dunstan, C., Blair, J., Zhou, H., Seibel, M. (2007). Bone, Mineral, Connective Tissue Metabolism. In Taylor J; Triggle D (vol ed Michael Williams) (Eds.), Comprehensive Medicinal Chemistry II, (pp. 495-520). Oxford, United Kingdom: Elsevier.

Journals

Macfarlane, E., Zhou, H., Seibel, M. (2024). The glucocorticoid receptor in skeletal health and disease: insights from targeted knockout mice. Journal of Endocrinology, 261(2), e230399. [More Information]
Macfarlane, E., Cavanagh, L., Fong-Yee, C., Tuckermann, J., Chen, D., Little, C., Seibel, M., Zhou, H. (2023). Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis. Osteoarthritis and Cartilage, 31(9), 1189-1201. [More Information]
Zhou, H., Seibel, M. (2023). Glucocorticoid action in osteoblasts and systemic energy metabolism. Current Opinion in Endocrine and Metabolic Research, 28. [More Information]
Yuan, J., Gao, Y., Liu, D., Pang Tai, A., Zhou, H., Papadimitriou, J., Zhang, C., Zheng, M., Gao, J. (2023). PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes. Journal of Orthopaedic Translation, 38, 229-240. [More Information]
Swarbrick, M., Zhou, H., Seibel, M. (2021). Local and systemic effects of glucocorticoids on metabolism: New lessons from animal models. European Journal of Endocrinology, 185(5), R113-R129. [More Information]
Kim, S., Henneicke, H., Cavanagh, L., Macfarlane, E., Thai, L., Foong, D., Gasparini, S., Fong-Yee, C., Swarbrick, M., Seibel, M., Zhou, H. (2021). Osteoblastic glucocorticoid signaling exacerbates high-fat-diet- induced bone loss and obesity. Bone Research, 9(1), 40. [More Information]
Macfarlane, E., Seibel, M., Zhou, H. (2020). Arthritis and the role of endogenous glucocorticoids. Bone Research, 8(1), 33. [More Information]
Chen, Y., Xin, H., Peng, H., Shi, Q., Li, M., Yu, J., Tian, Y., Han, X., Chen, X., Zheng, Y., Zhou, H., et al (2020). Hypomethylation-Linked Activation of PLCE1 Impedes Autophagy and Promotes Tumorigenesis through MDM2-Mediated Ubiquitination and Destabilization of p53. Cancer Research, 80(11), 2175-2189. [More Information]
Henneicke, H., Kim, S., Swarbrick, M., Li, J., Gasparini, S., Thai, J., Foong, D., Cavanagh, L., Fong-Yee, C., Karsten, E., Lin, R., Cooper, M., Zhou, H., Seibel, M. (2020). Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice. Molecular Metabolism, 42, 101098. [More Information]
Gasparini, S., Swarbrick, M., Kim, S., Thai, L., Henneicke, H., Cavanagh, L., Tu, J., Weber, M., Zhou, H., Seibel, M. (2019). Androgens sensitise mice to glucocorticoid-induced insulin resistance and fat accumulation. Diabetologia, 62(8), 1463-1477. [More Information]
Su, N., Yang, J., Xie, Y., Du, X., Chen, H., Zhou, H., Chen, L. (2019). Bone function, dysfunction and its role in diseases including critical illness. International Journal of Biological Sciences, 15(4), 776-787. [More Information]
Tu, J., Zhang, P., Ji, Z., Henneicke, H., Li, J., Kim, S., Swarbrick, M., Wu, Y., Little, C., Seibel, M., Zhou, H. (2019). Disruption of glucocorticoid signalling in osteoblasts attenuates age-related surgically induced osteoarthritis. Osteoarthritis and Cartilage, 27(10), 1518-1525. [More Information]
Chen, Y., Wang, D., Peng, H., Chen, X., Han, X., Yu, J., Wang, W., Liang, L., Liu, Z., Zheng, Y., Zhou, H., et al (2019). Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLC epsilon-NF-B signaling pathway and VEGF-C/ Bcl-2 expression. Molecular Cancer, 18(1), 1-19. [More Information]
Jorgensen, C., Zhou, H., Seibel, M., Brauner-Osbornune, H. (2019). Label-free dynamic mass redistribution analysis of endogenous adrenergic receptor signaling in primary preadipocytes and differentiated adipocytes. Journal of Pharmacological and Toxicological Methods, 97, 59-66. [More Information]
Horas, K., Zheng, Y., Fong-Yee, C., Macfarlane, E., Manibo, J., Chen, Y., Qiao, J., Gao, M., Haydar, N., McDonald, M., Zhou, H., Seibel, M., et al (2019). Loss of the Vitamin D Receptor in Human Breast Cancer Cells Promotes Epithelial to Mesenchymal Cell Transition and Skeletal Colonization. Journal of Bone and Mineral Research, 34(9), 1721-1732. [More Information]
Jorgensen, C., Gasparini, S., Tu, J., Zhou, H., Seibel, M., Brauner-Osborne, H. (2019). Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice. Scientific Reports, 9(1), 1-8. [More Information]
Yang, D., Anderson, P., Wijenayaka, A., Barratt, K., Triliana, R., Stapledon, C., Zhou, H., Findlay, D., Morris, H., Atkins, G. (2018). Both ligand and VDR expression levels critically determine the effect of 1(alpha), 25-dihydroxyvitamin-D3on osteoblast differentiation. Journal of Steroid Biochemistry and Molecular Biology, 177, 83-90. [More Information]
Kim, S., Foong, D., Cooper, M., Seibel, M., Zhou, H. (2018). Comparison of blood sampling methods for plasma corticosterone measurements in mice associated with minimal stress-related artefacts. Steroids, 135, 69-72. [More Information]
Tu, J., Stoner, S., Fromm, P., Wang, T., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2018). Endogenous glucocorticoid signaling in chondrocytes attenuates joint inflammation and damage. The FASEB Journal, 32(1), 478-487. [More Information]
Hardy, R., Zhou, H., Seibel, M., Cooper, M. (2018). Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy. Endocrine Reviews, 39(5), 519-548. [More Information]
Lv, Y., Yu, J., Sheng, Y., Huang, M., Kong, X., Di, W., Liu, J., Zhou, H., Liang, H., Ding, G. (2018). Glucocorticoids suppress the browning of adipose tissue via miR-19b in male mice. Endocrinology, 159(1), 310-322. [More Information]
Yu, J., Lv, Y., Di, W., Liu, J., Kong, X., Sheng, Y., Huang, M., Lv, S., Qi, H., Gao, M., Kim, S., Zhou, H., et al (2018). MiR-27b-3p Regulation in Browning of Human Visceral Adipose Related to Central Obesity. Obesity, 26(2), 387-396. [More Information]
Sattler, J., Tu, J., Stoner, S., Li, J., Buttgereit, F., Seibel, M., Zhou, H., Cooper, M. (2018). Role of 11[Beta]-HSD type 1 in abnormal HPA axis activity during immune-mediated arthritis. Endocrine Connections, 7(2), 385-394. [More Information]
Zhou, H., Seibel, M. (2017). Bone: Osteoblasts and global energy metabolism - beyond osteocalcin. Nature Reviews Rheumatology, 13(5), 261-262. [More Information]
Henneicke, H., Li, J., Kim, S., Gasparini, S., Seibel, M., Zhou, H. (2017). Chronic mild stress causes bone loss via an osteoblast-specific glucocorticoid-dependent mechanism. Endocrinology, 158(6), 1939-1950. [More Information]
Zheng, Y., Trivedi, T., Lin, R., Fong-Yee, C., Nolte, R., Manibo, J., Chen, Y., Hossain, M., Horas, K., Dunstan, C., Zhou, H., Seibel, M. (2017). Loss of the Vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/(Beta)-catenin signaling. Bone Research, 5, 1-12. [More Information]
Cui, X., Peng, H., Li, R., Mu, J., Yang, L., Li, N., Liu, C., Hu, J., Li, S., Zhou, H., et al (2017). MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma. Oncotarget, 8(54), 92454-92469. [More Information]
Trivedi, T., Zheng, Y., Fournier, P., Murthy, S., John, S., Schillo, S., Dunstan, C., Mohammad, K., Zhou, H., Seibel, M., et al (2017). The vitamin D receptor is involved in the regulation of human breast cancer cell growth via a ligand-independent function in cytoplasm. Oncotarget, 8(16), 26687-26701. [More Information]
Gasparini, S., Weber, M., Henneicke, H., Kim, S., Zhou, H., Seibel, M. (2016). Continuous corticosterone delivery via the drinking water or pellet implantation: A comparative study in mice. Steroids, 116, 76-82. [More Information]
Cooper, M., Seibel, M., Zhou, H. (2016). Glucocorticoids, bone and energy metabolism. Bone, 82, 64-68. [More Information]
Tu, J., Zhang, Y., Kim, S., Wiebe, E., Spies, C., Buttgereit, F., Cooper, M., Seibel, M., Zhou, H. (2016). Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts Attenuates Joint Inflammation in Collagen Antibody-Induced Arthritis. American Journal of Pathology, 186(5), 1293-1301. [More Information]
Henneicke, H., Gasparini, S., Zhou, H., Hofbauer, L., Seibel, M. (2016). Zelluläre Mechanismen der Gluko-kortikoid-induzierten Osteoporose und therapeutische Ansatzpunkte. Osteologie: interdisziplinaere Zeitschrift fur Knochen und Gelenke, 25(4), 247-252. [More Information]
Horas, K., Zheng, Y., Zhou, H., Seibel, M. (2015). Animal Models for Breast Cancer Metastasis to Bone: Opportunities and Limitations. Cancer Investigation, 33(9), 459-468. [More Information]
Zheng, L., Cao, H., Chen, S., Tang, T., Fu, W., Huang, L., Chow, D., Wang, Y., Griffith, J., He, W., Zhou, H., et al (2015). Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid-Associated Osteonecrosis in Rabbits. Journal of Bone and Mineral Research, 30(11), 2044-2057. [More Information]
Wang, T., Li, J., Jin, Z., Wu, F., Li, Y., Wang, X., Zhou, H., Zhou, Q. (2015). Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis. Korean Journal of Physiology and Pharmacology, 19(2), 83-88. [More Information]
Kong, X., Yu, J., Bi, J., Qi, H., Di, W., Wu, L., Wang, L., Zha, J., Lv, S., Zhang, F., Zhou, H., et al (2015). Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue. Diabetes, 64(2), 393-404. [More Information]
Bermeo, S., Vidal, C., Zhou, H., Duque, G. (2015). Lamin A/C Acts as an Essential Factor in Mesenchymal Stem Cell Differentiation through the Regulation of the Dynamics of the Wnt/B-Catenin Pathway. Journal Of Cellular Biochemistry, 116(10), 2344-2353. [More Information]
Ji, Z., Dang, X., Wang, K., Zhou, H. (2015). Micro-CT analysis on subchondral-bone microstructure of tibia in a mouse model of osteoarthritis. Journal of Xi'an Jiaotong University (Medical Sciences), 36(5), 623-627 and 654. [More Information]
Cui, X., Li, S., Li, T., Peng, H., Jin, T., Zhang, S., Liu, C., Yang, L., Zhou, H., Zheng, Y., et al (2015). Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget, 7(2), 1777-1795. [More Information]
Spies, C., Wiebe, E., Tu, J., Li, A., Gaber, T., Huscher, D., Seibel, M., Zhou, H., Buttgereit, F. (2014). Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling. BMC Musculoskeletal Disorders, 15, 1-11. [More Information]
Gao, Y., Walters, K., Desai, R., Zhou, H., Handelsman, D., Simanainen, U. (2014). Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERÎ± expression, and Wnt/Î²-catenin signaling in female mice. Endocrinology, 155(12), 4951-4963. [More Information]
Zheng, Y., Chow, S., Boernert, K., Basel, D., Mikuscheva, A., Kim, S., Fong-Yee, C., Trivedi, T., Buttgereit, F., Sutherland, R., Dunstan, C., Zhou, H., Seibel, M. (2014). Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways. Journal of Bone and Mineral Research, 29(9), 1938-1949. [More Information]
Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information]
Zhao, B., Choi, J., Jaehne, M., Gao, Y., Desai, R., Tuckermann, J., Zhou, H., Handelsman, D., Simanainen, U. (2014). Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. The Prostate, 74(10), 1068-1078. [More Information]
Henneicke, H., Gasparini, S., Brennan-Speranza, T., Zhou, H., Seibel, M. (2014). Glucocorticoids and bone: local effects and systemic implications. Trends in Endocrinology and Metabolism, 25(4), 197-211. [More Information]
Zheng, Y., Basel, D., Chow, S., Fong-Yee, C., Kim, S., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2014). Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone. Clinical and Experimental Metastasis, 31(8), 921-933. [More Information]
Hardy, R., Hulso, C., Liu, Y., Gasparini, S., Fong-Yee, C., Tu, J., Stoner, S., Stewart, P., Raza, K., Cooper, M., Seibel, M., Zhou, H. (2013). Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Research and Therapy, 15(1), 1-14. [More Information]
Li, A., Hardy, R., Stoner, S., Tuckermann, J., Seibel, M., Zhou, H. (2013). Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PloS One, 8(5), 1-11. [More Information]
Zhou, H., Cooper, M., Seibel, M. (2013). Endogenous Glucocorticoids and Bone. Bone Research, 1, 107-119. [More Information]
Seibel, M., Cooper, M., Zhou, H. (2013). Glucocorticoid-induced osteoporosis: Mechanisms, management, and future perspectives. The Lancet Diabetes and Endocrinology, 1(1), 59-70. [More Information]
Zheng, Y., Zhou, H., Dunstan, C., Sutherland, R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology, 2(1), 47-57. [More Information]
Georgiou, K., King, T., Scherer, M., Zhou, H., Foster, B., Xian, C. (2012). Attenuated Wnt/beta-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone, 50(6), 1223-1233. [More Information]
Brennan-Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
Cooper, M., Zhou, H., Seibel, M. (2012). Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets? Journal of Bone and Mineral Research, 27(11), 2238-2241. [More Information]
Henneicke, H., Herrmann, M., Kalak, R., Brennan-Speranza, T., Bertollo, N., Day, R., Huscher, D., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone, 49(4), 733-742. [More Information]
Buttgereit, F., Burmester, G., Straub, R., Seibel, M., Zhou, H. (2011). Exogenous and endogenous glucocorticoids in rheumatic diseases. Arthritis & Rheumatology, 63(1), 1-9. [More Information]
Allan, C., Kalak, R., Dunstan, C., McTavish, K., Zhou, H., Handelsman, D., Seibel, M. (2010). Follicle-stimulating hormone increases bone mass in female mice. Proceedings of the National Academy of Sciences of the United States of America, 107(52), 22629-22634. [More Information]
Liu, P., Kalak, R., Lue, Y., Jia, Y., Erkkila, K., Zhou, H., Seibel, M., Wang, C., Swerdloff, R., Dunstan, C. (2010). Genetic and Hormonal Control of Bone Volume, Architecture, and Remodeling in XXY Mice. Journal of Bone and Mineral Research, 25(10), 2148-2154. [More Information]
Simanainen, U., Lampinen, A., Henneicke, H., Brennan-Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
Weber, A., Li, G., Kalak, R., Street, J., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2010). Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing. Steroids, 75(3), 282-286. [More Information]
Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan, C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The Prostate, 71(9), 1012-1021. [More Information]
Mak, W., Shao, X., Dunstan, C., Seibel, M., Zhou, H. (2009). Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcified Tissue International, 85(6), 538-545. [More Information]
Kalak, R., Zhou, H., Street, J., Day, R., Modzelewski, J., Spies, C., Liu, P., Li, G., Dunstan, C., Seibel, M. (2009). Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone, 45(1), 61-67. [More Information]
Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M. (2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice. Development, 136(3), 427-436. [More Information]
Herrmann, M., Henneicke, H., Street, J., Modzelewski, J., Kalak, R., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2009). The challenge of continuous exogenous glucocorticoid administration in mice. Steroids, 74(2), 245-249. [More Information]
Buttgereit, F., Zhou, H., Kalak, R., Gaber, T., Spies, C., Huscher, D., Straub, R., Modzelewski, J., Dunstan, C., Seibel, M. (2009). Transgenic Disruption of Glucocorticoid Signaling in Mature Osteoblasts and Osteocytes Attenuates K/BxN Mouse Serum-Induced Arthritis In Vivo. Arthritis Care and Research, 60(7), 1998-2007. [More Information]
Buttgereit, F., Zhou, H., Seibel, M. (2008). Arthritis and endogenous glucocorticoids: the emerging role of the 11beta-HSD enzymes. Annals of the Rheumatic Diseases, 67(9), 1201-1203. [More Information]
Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
Zheng, Y., Zhou, H., Fong-Yee, C., Modzelewski, J., Seibel, M., Dunstan, C. (2008). Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental Metastasis, 25(5), 559-567. [More Information]
Zhou, H., Mak, W., Zheng, Y., Dunstan, C., Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of Biological Chemistry, 283(4), 1936-1945. [More Information]
Kartsogiannis, V., Sims, N., Quinn, J., Ly, C., Cipetic, M., Poulton, I., Walker, E., Saleh, H., Zhou, H., et al (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. Journal of Biological Chemistry, 283(45), 30850-30860. [More Information]
Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R., Blair, J., Seibel, M., Dunstan, C. (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research, 67(19), 9542-9548. [More Information]
Blair, J., Zhou, H., Seibel, M., Dunstan, C. (2006). Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nature Clinical Practice Oncology, 3(1), 41-49. [More Information]
Seibel, M., Dunstan, C., Zhou, H., Allan, C., Handelsman, D. (2006). Sex steroids, not FSH, influence bone mass. Cell, 127(6), 1079-1079. [More Information]
Dunstan, C., Zhou, H., Seibel, M. (2004). Fibroblast Growth Factor 23: A Phospatonin Regulating Phosphate Homeostasis? Endocrinology, 145(7), 3084-3086. [More Information]

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Reference Works

Zhou, H., Chen, D., Dunstan, C., Seibel, M. (2009). Bone Metabolism. In Stefan Offermanns, Walter Rosenthal (Eds.), Bone Metabolism. (Vol. 1, pp. 276-282). USA: Springer.

By Year

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2024

Macfarlane, E., Zhou, H., Seibel, M. (2024). The glucocorticoid receptor in skeletal health and disease: insights from targeted knockout mice. Journal of Endocrinology, 261(2), e230399. [More Information]

2023

Macfarlane, E., Cavanagh, L., Fong-Yee, C., Tuckermann, J., Chen, D., Little, C., Seibel, M., Zhou, H. (2023). Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis. Osteoarthritis and Cartilage, 31(9), 1189-1201. [More Information]
Zhou, H., Seibel, M. (2023). Glucocorticoid action in osteoblasts and systemic energy metabolism. Current Opinion in Endocrine and Metabolic Research, 28. [More Information]
Yuan, J., Gao, Y., Liu, D., Pang Tai, A., Zhou, H., Papadimitriou, J., Zhang, C., Zheng, M., Gao, J. (2023). PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes. Journal of Orthopaedic Translation, 38, 229-240. [More Information]

2021

Swarbrick, M., Zhou, H., Seibel, M. (2021). Local and systemic effects of glucocorticoids on metabolism: New lessons from animal models. European Journal of Endocrinology, 185(5), R113-R129. [More Information]
Kim, S., Henneicke, H., Cavanagh, L., Macfarlane, E., Thai, L., Foong, D., Gasparini, S., Fong-Yee, C., Swarbrick, M., Seibel, M., Zhou, H. (2021). Osteoblastic glucocorticoid signaling exacerbates high-fat-diet- induced bone loss and obesity. Bone Research, 9(1), 40. [More Information]

2020

Macfarlane, E., Seibel, M., Zhou, H. (2020). Arthritis and the role of endogenous glucocorticoids. Bone Research, 8(1), 33. [More Information]
Chen, Y., Xin, H., Peng, H., Shi, Q., Li, M., Yu, J., Tian, Y., Han, X., Chen, X., Zheng, Y., Zhou, H., et al (2020). Hypomethylation-Linked Activation of PLCE1 Impedes Autophagy and Promotes Tumorigenesis through MDM2-Mediated Ubiquitination and Destabilization of p53. Cancer Research, 80(11), 2175-2189. [More Information]
Henneicke, H., Kim, S., Swarbrick, M., Li, J., Gasparini, S., Thai, J., Foong, D., Cavanagh, L., Fong-Yee, C., Karsten, E., Lin, R., Cooper, M., Zhou, H., Seibel, M. (2020). Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice. Molecular Metabolism, 42, 101098. [More Information]

2019

Gasparini, S., Swarbrick, M., Kim, S., Thai, L., Henneicke, H., Cavanagh, L., Tu, J., Weber, M., Zhou, H., Seibel, M. (2019). Androgens sensitise mice to glucocorticoid-induced insulin resistance and fat accumulation. Diabetologia, 62(8), 1463-1477. [More Information]
Su, N., Yang, J., Xie, Y., Du, X., Chen, H., Zhou, H., Chen, L. (2019). Bone function, dysfunction and its role in diseases including critical illness. International Journal of Biological Sciences, 15(4), 776-787. [More Information]
Tu, J., Zhang, P., Ji, Z., Henneicke, H., Li, J., Kim, S., Swarbrick, M., Wu, Y., Little, C., Seibel, M., Zhou, H. (2019). Disruption of glucocorticoid signalling in osteoblasts attenuates age-related surgically induced osteoarthritis. Osteoarthritis and Cartilage, 27(10), 1518-1525. [More Information]
Chen, Y., Wang, D., Peng, H., Chen, X., Han, X., Yu, J., Wang, W., Liang, L., Liu, Z., Zheng, Y., Zhou, H., et al (2019). Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLC epsilon-NF-B signaling pathway and VEGF-C/ Bcl-2 expression. Molecular Cancer, 18(1), 1-19. [More Information]
Jorgensen, C., Zhou, H., Seibel, M., Brauner-Osbornune, H. (2019). Label-free dynamic mass redistribution analysis of endogenous adrenergic receptor signaling in primary preadipocytes and differentiated adipocytes. Journal of Pharmacological and Toxicological Methods, 97, 59-66. [More Information]
Horas, K., Zheng, Y., Fong-Yee, C., Macfarlane, E., Manibo, J., Chen, Y., Qiao, J., Gao, M., Haydar, N., McDonald, M., Zhou, H., Seibel, M., et al (2019). Loss of the Vitamin D Receptor in Human Breast Cancer Cells Promotes Epithelial to Mesenchymal Cell Transition and Skeletal Colonization. Journal of Bone and Mineral Research, 34(9), 1721-1732. [More Information]
Jorgensen, C., Gasparini, S., Tu, J., Zhou, H., Seibel, M., Brauner-Osborne, H. (2019). Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice. Scientific Reports, 9(1), 1-8. [More Information]

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2018

Yang, D., Anderson, P., Wijenayaka, A., Barratt, K., Triliana, R., Stapledon, C., Zhou, H., Findlay, D., Morris, H., Atkins, G. (2018). Both ligand and VDR expression levels critically determine the effect of 1(alpha), 25-dihydroxyvitamin-D3on osteoblast differentiation. Journal of Steroid Biochemistry and Molecular Biology, 177, 83-90. [More Information]
Kim, S., Foong, D., Cooper, M., Seibel, M., Zhou, H. (2018). Comparison of blood sampling methods for plasma corticosterone measurements in mice associated with minimal stress-related artefacts. Steroids, 135, 69-72. [More Information]
Tu, J., Stoner, S., Fromm, P., Wang, T., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2018). Endogenous glucocorticoid signaling in chondrocytes attenuates joint inflammation and damage. The FASEB Journal, 32(1), 478-487. [More Information]
Hardy, R., Zhou, H., Seibel, M., Cooper, M. (2018). Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy. Endocrine Reviews, 39(5), 519-548. [More Information]
Lv, Y., Yu, J., Sheng, Y., Huang, M., Kong, X., Di, W., Liu, J., Zhou, H., Liang, H., Ding, G. (2018). Glucocorticoids suppress the browning of adipose tissue via miR-19b in male mice. Endocrinology, 159(1), 310-322. [More Information]
Yu, J., Lv, Y., Di, W., Liu, J., Kong, X., Sheng, Y., Huang, M., Lv, S., Qi, H., Gao, M., Kim, S., Zhou, H., et al (2018). MiR-27b-3p Regulation in Browning of Human Visceral Adipose Related to Central Obesity. Obesity, 26(2), 387-396. [More Information]
Sattler, J., Tu, J., Stoner, S., Li, J., Buttgereit, F., Seibel, M., Zhou, H., Cooper, M. (2018). Role of 11[Beta]-HSD type 1 in abnormal HPA axis activity during immune-mediated arthritis. Endocrine Connections, 7(2), 385-394. [More Information]

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2017

Zhou, H., Seibel, M. (2017). Bone: Osteoblasts and global energy metabolism - beyond osteocalcin. Nature Reviews Rheumatology, 13(5), 261-262. [More Information]
Henneicke, H., Li, J., Kim, S., Gasparini, S., Seibel, M., Zhou, H. (2017). Chronic mild stress causes bone loss via an osteoblast-specific glucocorticoid-dependent mechanism. Endocrinology, 158(6), 1939-1950. [More Information]
Zheng, Y., Trivedi, T., Lin, R., Fong-Yee, C., Nolte, R., Manibo, J., Chen, Y., Hossain, M., Horas, K., Dunstan, C., Zhou, H., Seibel, M. (2017). Loss of the Vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/(Beta)-catenin signaling. Bone Research, 5, 1-12. [More Information]
Cui, X., Peng, H., Li, R., Mu, J., Yang, L., Li, N., Liu, C., Hu, J., Li, S., Zhou, H., et al (2017). MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma. Oncotarget, 8(54), 92454-92469. [More Information]
Trivedi, T., Zheng, Y., Fournier, P., Murthy, S., John, S., Schillo, S., Dunstan, C., Mohammad, K., Zhou, H., Seibel, M., et al (2017). The vitamin D receptor is involved in the regulation of human breast cancer cell growth via a ligand-independent function in cytoplasm. Oncotarget, 8(16), 26687-26701. [More Information]

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2016

Gasparini, S., Weber, M., Henneicke, H., Kim, S., Zhou, H., Seibel, M. (2016). Continuous corticosterone delivery via the drinking water or pellet implantation: A comparative study in mice. Steroids, 116, 76-82. [More Information]
Cooper, M., Seibel, M., Zhou, H. (2016). Glucocorticoids, bone and energy metabolism. Bone, 82, 64-68. [More Information]
Tu, J., Zhang, Y., Kim, S., Wiebe, E., Spies, C., Buttgereit, F., Cooper, M., Seibel, M., Zhou, H. (2016). Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts Attenuates Joint Inflammation in Collagen Antibody-Induced Arthritis. American Journal of Pathology, 186(5), 1293-1301. [More Information]
Henneicke, H., Gasparini, S., Zhou, H., Hofbauer, L., Seibel, M. (2016). Zelluläre Mechanismen der Gluko-kortikoid-induzierten Osteoporose und therapeutische Ansatzpunkte. Osteologie: interdisziplinaere Zeitschrift fur Knochen und Gelenke, 25(4), 247-252. [More Information]

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2015

Horas, K., Zheng, Y., Zhou, H., Seibel, M. (2015). Animal Models for Breast Cancer Metastasis to Bone: Opportunities and Limitations. Cancer Investigation, 33(9), 459-468. [More Information]
Zheng, L., Cao, H., Chen, S., Tang, T., Fu, W., Huang, L., Chow, D., Wang, Y., Griffith, J., He, W., Zhou, H., et al (2015). Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid-Associated Osteonecrosis in Rabbits. Journal of Bone and Mineral Research, 30(11), 2044-2057. [More Information]
Wang, T., Li, J., Jin, Z., Wu, F., Li, Y., Wang, X., Zhou, H., Zhou, Q. (2015). Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis. Korean Journal of Physiology and Pharmacology, 19(2), 83-88. [More Information]
Kong, X., Yu, J., Bi, J., Qi, H., Di, W., Wu, L., Wang, L., Zha, J., Lv, S., Zhang, F., Zhou, H., et al (2015). Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue. Diabetes, 64(2), 393-404. [More Information]
Bermeo, S., Vidal, C., Zhou, H., Duque, G. (2015). Lamin A/C Acts as an Essential Factor in Mesenchymal Stem Cell Differentiation through the Regulation of the Dynamics of the Wnt/B-Catenin Pathway. Journal Of Cellular Biochemistry, 116(10), 2344-2353. [More Information]
Ji, Z., Dang, X., Wang, K., Zhou, H. (2015). Micro-CT analysis on subchondral-bone microstructure of tibia in a mouse model of osteoarthritis. Journal of Xi'an Jiaotong University (Medical Sciences), 36(5), 623-627 and 654. [More Information]
Cui, X., Li, S., Li, T., Peng, H., Jin, T., Zhang, S., Liu, C., Yang, L., Zhou, H., Zheng, Y., et al (2015). Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget, 7(2), 1777-1795. [More Information]

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2014

Spies, C., Wiebe, E., Tu, J., Li, A., Gaber, T., Huscher, D., Seibel, M., Zhou, H., Buttgereit, F. (2014). Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling. BMC Musculoskeletal Disorders, 15, 1-11. [More Information]
Gao, Y., Walters, K., Desai, R., Zhou, H., Handelsman, D., Simanainen, U. (2014). Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERÎ± expression, and Wnt/Î²-catenin signaling in female mice. Endocrinology, 155(12), 4951-4963. [More Information]
Zheng, Y., Chow, S., Boernert, K., Basel, D., Mikuscheva, A., Kim, S., Fong-Yee, C., Trivedi, T., Buttgereit, F., Sutherland, R., Dunstan, C., Zhou, H., Seibel, M. (2014). Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways. Journal of Bone and Mineral Research, 29(9), 1938-1949. [More Information]
Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information]
Zhao, B., Choi, J., Jaehne, M., Gao, Y., Desai, R., Tuckermann, J., Zhou, H., Handelsman, D., Simanainen, U. (2014). Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. The Prostate, 74(10), 1068-1078. [More Information]
Henneicke, H., Gasparini, S., Brennan-Speranza, T., Zhou, H., Seibel, M. (2014). Glucocorticoids and bone: local effects and systemic implications. Trends in Endocrinology and Metabolism, 25(4), 197-211. [More Information]
Zheng, Y., Basel, D., Chow, S., Fong-Yee, C., Kim, S., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2014). Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone. Clinical and Experimental Metastasis, 31(8), 921-933. [More Information]

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2013

Hardy, R., Hulso, C., Liu, Y., Gasparini, S., Fong-Yee, C., Tu, J., Stoner, S., Stewart, P., Raza, K., Cooper, M., Seibel, M., Zhou, H. (2013). Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Research and Therapy, 15(1), 1-14. [More Information]
Li, A., Hardy, R., Stoner, S., Tuckermann, J., Seibel, M., Zhou, H. (2013). Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PloS One, 8(5), 1-11. [More Information]
Zhou, H., Cooper, M., Seibel, M. (2013). Endogenous Glucocorticoids and Bone. Bone Research, 1, 107-119. [More Information]
Seibel, M., Cooper, M., Zhou, H. (2013). Glucocorticoid-induced osteoporosis: Mechanisms, management, and future perspectives. The Lancet Diabetes and Endocrinology, 1(1), 59-70. [More Information]
Zheng, Y., Zhou, H., Dunstan, C., Sutherland, R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology, 2(1), 47-57. [More Information]

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2012

Georgiou, K., King, T., Scherer, M., Zhou, H., Foster, B., Xian, C. (2012). Attenuated Wnt/beta-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone, 50(6), 1223-1233. [More Information]
Brennan-Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
Cooper, M., Zhou, H., Seibel, M. (2012). Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets? Journal of Bone and Mineral Research, 27(11), 2238-2241. [More Information]

2011

Henneicke, H., Herrmann, M., Kalak, R., Brennan-Speranza, T., Bertollo, N., Day, R., Huscher, D., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone, 49(4), 733-742. [More Information]
Buttgereit, F., Burmester, G., Straub, R., Seibel, M., Zhou, H. (2011). Exogenous and endogenous glucocorticoids in rheumatic diseases. Arthritis & Rheumatology, 63(1), 1-9. [More Information]
Zheng, Y., Seibel, M., Zhou, H. (2011). Methods in Bone Biology: Cancer and Bone. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 83-91). London: Springer. [More Information]

2010

Allan, C., Kalak, R., Dunstan, C., McTavish, K., Zhou, H., Handelsman, D., Seibel, M. (2010). Follicle-stimulating hormone increases bone mass in female mice. Proceedings of the National Academy of Sciences of the United States of America, 107(52), 22629-22634. [More Information]
Liu, P., Kalak, R., Lue, Y., Jia, Y., Erkkila, K., Zhou, H., Seibel, M., Wang, C., Swerdloff, R., Dunstan, C. (2010). Genetic and Hormonal Control of Bone Volume, Architecture, and Remodeling in XXY Mice. Journal of Bone and Mineral Research, 25(10), 2148-2154. [More Information]
Simanainen, U., Lampinen, A., Henneicke, H., Brennan-Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
Weber, A., Li, G., Kalak, R., Street, J., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2010). Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing. Steroids, 75(3), 282-286. [More Information]
Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan, C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The Prostate, 71(9), 1012-1021. [More Information]

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2009

Mak, W., Shao, X., Dunstan, C., Seibel, M., Zhou, H. (2009). Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcified Tissue International, 85(6), 538-545. [More Information]
Zhou, H., Chen, D., Dunstan, C., Seibel, M. (2009). Bone Metabolism. In Stefan Offermanns, Walter Rosenthal (Eds.), Bone Metabolism. (Vol. 1, pp. 276-282). USA: Springer.
Kalak, R., Zhou, H., Street, J., Day, R., Modzelewski, J., Spies, C., Liu, P., Li, G., Dunstan, C., Seibel, M. (2009). Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone, 45(1), 61-67. [More Information]
Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M. (2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice. Development, 136(3), 427-436. [More Information]
Herrmann, M., Henneicke, H., Street, J., Modzelewski, J., Kalak, R., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2009). The challenge of continuous exogenous glucocorticoid administration in mice. Steroids, 74(2), 245-249. [More Information]
Buttgereit, F., Zhou, H., Kalak, R., Gaber, T., Spies, C., Huscher, D., Straub, R., Modzelewski, J., Dunstan, C., Seibel, M. (2009). Transgenic Disruption of Glucocorticoid Signaling in Mature Osteoblasts and Osteocytes Attenuates K/BxN Mouse Serum-Induced Arthritis In Vivo. Arthritis Care and Research, 60(7), 1998-2007. [More Information]

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2008

Buttgereit, F., Zhou, H., Seibel, M. (2008). Arthritis and endogenous glucocorticoids: the emerging role of the 11beta-HSD enzymes. Annals of the Rheumatic Diseases, 67(9), 1201-1203. [More Information]
Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
Zheng, Y., Zhou, H., Fong-Yee, C., Modzelewski, J., Seibel, M., Dunstan, C. (2008). Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental Metastasis, 25(5), 559-567. [More Information]
Zhou, H., Mak, W., Zheng, Y., Dunstan, C., Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of Biological Chemistry, 283(4), 1936-1945. [More Information]
Kartsogiannis, V., Sims, N., Quinn, J., Ly, C., Cipetic, M., Poulton, I., Walker, E., Saleh, H., Zhou, H., et al (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. Journal of Biological Chemistry, 283(45), 30850-30860. [More Information]

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2007

Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R., Blair, J., Seibel, M., Dunstan, C. (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research, 67(19), 9542-9548. [More Information]
Dunstan, C., Blair, J., Zhou, H., Seibel, M. (2007). Bone, Mineral, Connective Tissue Metabolism. In Taylor J; Triggle D (vol ed Michael Williams) (Eds.), Comprehensive Medicinal Chemistry II, (pp. 495-520). Oxford, United Kingdom: Elsevier.

2006

Blair, J., Zhou, H., Seibel, M., Dunstan, C. (2006). Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nature Clinical Practice Oncology, 3(1), 41-49. [More Information]
Seibel, M., Dunstan, C., Zhou, H., Allan, C., Handelsman, D. (2006). Sex steroids, not FSH, influence bone mass. Cell, 127(6), 1079-1079. [More Information]

2004

Dunstan, C., Zhou, H., Seibel, M. (2004). Fibroblast Growth Factor 23: A Phospatonin Regulating Phosphate Homeostasis? Endocrinology, 145(7), 3084-3086. [More Information]

Selected Grants

2023

Glucocorticoid rhythmicity and its critical role in bone loss and osteoarthritis during chronic disruption of circadian rhythm, Zhou H, Macfarlane E, Meng Q, National Health and Medical Research Council (NHMRC)/Ideas Grant

2013

EVOS FL Auto cell imaging system, Allan C, Clark G, Cogger V, Cooper M, Fromm P, Handelsman D, Hart D, Jessup W, Kennerson M, Kockx M, Kritharides L, Le Couteur D, McLachlan A, McMahon A, Nicholson G, Seibel M, Silveira P, Simanainen U, Verma N, Walters K, Zheng Y, Zhou H, National Health and Medical Research Council (NHMRC)/Equipment Grant

2012

The Role of Osteoblastic Glucocorticoid in Ageing, Zhou H, DVC Research/Bridging Support Grant
IVIS Lumina II in vivo Imaging System, Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Brennan-Speranza T, Zheng Y, DVC Research/Equipment Grant
Automacs Pro Seperator, Hart D, Handelsman D, Le Couteur D, Nicholson G, Kritharides L, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, Simanainen U, Zheng Y, Seibel M, DVC Research/Equipment Grant
Novel Cytoplasmic Functions of the Vitamin D Receptor in Bone Metastases, Seibel M, Zheng Y, Croucher P, Zhou H, Guise T, Dunstan C, Cancer Council NSW/Research Project Grants

2010

The role of endogenous glucocorticoids in Inflammatory arthritis, Seibel M, Zhou H, Rebecca L Cooper Medical Research Foundation/Equipment Grant
MOLECULAR IMAGER CHEMIDoc XRS SYSTEM & MINI P ROTEAN GEL/TRANSBLOT Cell SYSTEM (BIO-RAD. AUSTRALIA, Allan C, Handelsman D, Zhou H, Seibel M, Kennerson M, Nicholson G, Blair I, Le Couteur D, McMahon A, Hart D, Clark G, Simanainen U, National Health and Medical Research Council (NHMRC)/Equipment Grant

2009

The role of endogenous glucocorticoids in Autoimmune Arthritis, Cooper M, Zhou H, Seibel M, Stewart P, Buttgereit F, Cooper M, National Health and Medical Research Council (NHMRC)/Project Grants
The Role of the Osteoblast in Mediating Glucocorticoid-induced Metabolic Dysfunction, Seibel M, Zhou H, Gundberg C, Dunstan C, National Health and Medical Research Council (NHMRC)/Project Grants
The Lunar PIXImus II DEXA Scanner, Zhou H, Seibel M, Handelsman D, Le Couteur D, Nicholson G, Clarke S, Robertson G, van Zandwijk N, Freedman B, Kennerson M, Allan C, Walters K, Cogger V, Blair I, Reid G, Simanainen U, National Health and Medical Research Council (NHMRC)/Equipment Grant
Role of Lamin A/C in Osteoblastogenesis and Age-related Bone Loss, Duque G, Zhou H, Drissi H, Li W, National Health and Medical Research Council (NHMRC)/Project Grants

2008

A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation, Archer M, Cairney J, Darendeliler M, Einav I, Hand S, Jones A, Li Q, Masters A, Munroe P, Murphy C, Ramzan I, Richardson D, Ringer S, Seibel M, Swain M, Traini D, Wang X, Young P, Zhang Y, Zhou H, Milthorpe B, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
Osteoblast Control of Mesenchymal Progenitor Cell Differentiation: The Role of Glucocorticoids and Wnt Signalling, Chen D, Zhou H, Seibel M, Chen D, Dunstan C, National Health and Medical Research Council (NHMRC)/Project Grants
Stereomicroscope-Imaging Workstation, Allan C, Seibel M, Handelsman D, Le Couteur D, Kennerson M, Robertson G, Walters K, Cogger V, Nicholson G, Zhou H, Blair I, Simanainen U, McMahon A, National Health and Medical Research Council (NHMRC)/Equipment Grant

2007

How Osteoblasts control Mesenchymal Progenitors: A Novel Concept of Interaction between Mature and I, Zhou H, University of Sydney/Bridging Support

2006

Leica CM3050 S cryostat, Allan C, Blair J, Dunstan C, Handelsman D, Kennerson M, Lowe H, Nicholson G, Seibel M, Witting P, Zhou H, University of Sydney/Major Equipment Grant

2005

Cell culture quarantine and storage facility plus assessories, Dunstan C, Witting P, Myers S, Handelsman D, Seibel M, Nicholson G, Zhou H, Kennerson M, Allan C, Freedman B, Le Couteur D, Muller M, National Health and Medical Research Council (NHMRC)/Equipment Grant
Glucocorticoid effects on bone: the role of the osteoblast, Seibel M, Zhou H, Dunstan C, Krozowski Z, National Health and Medical Research Council (NHMRC)/Project Grants

2004

Bone resorption in breast cancer metastasis, Blair J, Dunstan C, Seibel M, Zhou H, National Health and Medical Research Council (NHMRC)/Project Grants

Faculty of Medicine and Health

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Professor Hong Zhou

Publications

By Type

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Selected Grants

2023

2013

2012

2010

2009

2008

2007

2006

2005

2004