Professor Harry Iland
People_

Professor Harry Iland

Clinical Professor
Sydney Medical School
Central Clinical School
Faculty of Medicine and Health
Phone
+61 2 9515 7451
Fax
+61 2 9515 6698
Professor Harry Iland

His main interests have encompassed molecular abnormalities in haematological malignancies, and he established one of the earliest molecular diagnostic laboratories for haematological malignancy in Australia. In the last few years he has been responsible for the Australasian Leukaemia and Lymphoma Group's clinical trial program in acute promyelocytic leukaemia (APL), and has combined this with an active laboratory program in the molecular analysis of APL cells. His laboratory has also established molecular assays relevant for patients with idiopathic hypereosinophilic syndrome / chronic eosinophilic leukaemia.

Cancer

Selected publications

Publications

Edited Books

  • Iland, H., Hertzberg, M., Marlton, P. (2005). Myeloid Leukemia: Methods and Protocols. Humana Press.

Book Chapters

  • Iland, H. (2000). Detection of minimal residual disease in hematologic malignancies by molecular technology. In Kerry Atkinson (Eds.), Clinical Bone Marrow and Blood Stem Cell Transplantation, (pp. 1659-1675). New York, USA: Cambridge University Press.

Journals

  • Iland, H., Reynolds, J., McMullin, M., Martin, A., Tan, P., Taussig, D., Wong, A., Taper, J., Fraga, C., Kelly, R., et al (2023). Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation. Blood Advances, 7(11), 2580-2585. [More Information]
  • Loo, S., Bilmon, I., Taper, J., Cull, G., Tiley, C., Verner, E., Hahn, U., Hiwase, D., Iland, H., Murphy, N., Murray, M., et al (2023). Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML: a randomized, placebo-controlled study by the ALLG. Blood, 142(23), 1960-1971. [More Information]
  • Enjeti, A., Agarwal, R., Blombery, P., Chee, L., Chua, C., Grigg, A., Hamad, N., Iland, H., Lane, S., Perkins, A., et al (2022). Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement. Pathology, 54(4), 389-398. [More Information]

2023

  • Iland, H., Reynolds, J., McMullin, M., Martin, A., Tan, P., Taussig, D., Wong, A., Taper, J., Fraga, C., Kelly, R., et al (2023). Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation. Blood Advances, 7(11), 2580-2585. [More Information]
  • Loo, S., Bilmon, I., Taper, J., Cull, G., Tiley, C., Verner, E., Hahn, U., Hiwase, D., Iland, H., Murphy, N., Murray, M., et al (2023). Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML: a randomized, placebo-controlled study by the ALLG. Blood, 142(23), 1960-1971. [More Information]

2022

  • Enjeti, A., Agarwal, R., Blombery, P., Chee, L., Chua, C., Grigg, A., Hamad, N., Iland, H., Lane, S., Perkins, A., et al (2022). Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement. Pathology, 54(4), 389-398. [More Information]

2021

  • Corboy, G., Othman, J., Lee, L., Wei, A., Ivey, A., Blombery, P., Agarwal, R., Fong, C., Brown, A., Scott, H., Iland, H., et al (2021). Laboratory quality assessment of candidate gene panel testing for acute myeloid leukaemia: a joint ALLG / RCPAQAP initiative. Pathology, 53(4), 487-492. [More Information]

2019

  • Abadir, E., Gasiorowski, R., Lai, K., Kupresanin, F., Romano, A., Silveira, P., Lo, T., Fromm, P., Kennerson, M., Iland, H., Ho, P., Hart, D., Clark, G., et al (2019). CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation. Molecular Oncology, 13(10), 2107-2120. [More Information]
  • Iland, H. (2019). Curative strategies in APL. Seminars in Hematology, 56(2), 131-138. [More Information]
  • Sanz, M., Fenaux, P., Tallman, M., Estey, E., Lowenberg, B., Naoe, T., Lengfelder, E., Dohner, H., Burnett, A., Chen, S., Iland, H., et al (2019). Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet. Blood, 133(15), 1630-1643. [More Information]

2018

  • Hsu, J., Bryant, C., Papadimitrious, M., Kong, B., Gasiorowski, R., Orellana, D., McGuire, H., Fazekas de St Groth, B., Joshua, D., Ho, P., Iland, H., Gibson, J., Clark, G., Fromm, P., Hart, D., et al (2018). A blood dendritic cell vaccine for acute myeloid leukemia expands anti-tumor T cell responses at remission. OncoImmunology, 7(4), e1419114-1-e1419114-11. [More Information]

2017

  • Mantha, S., Goldman, D., Devlin, S., Lee, J., Zannino, D., Collins, M., Douer, D., Iland, H., Litzow, M., Stein, E., et al (2017). Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era. Blood, 129(13), 1763-1767. [More Information]
  • McCulloch, D., Brown, C., Iland, H. (2017). Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives. OncoTargets and Therapy, 10, 1585-1601. [More Information]
  • Kommers, I., Bartley, P., Budgen, B., Latham, S., Beligaswatte, A., Supple, S., Catalano, A., Iland, H., Morley, A., Ross, D. (2017). Sensitive monitoring of acute promyelocytic leukemia by PML-RARA DNA Q-PCR. Leukemia and Lymphoma, 58(7), 1767-1769. [More Information]

2016

  • Mohamed, M., Iland, H., Sharma, S., Supple, S. (2016). Atypical presentation of therapy-related acute promyelocytic leukaemia with marrow fibrosis. Pathology, 48(3), 286-288. [More Information]

2015

  • He, S., Busfield, S., Ritchie, D., Hertzberg, M., Durrant, S., Lewis, I., Marlton, P., McLachlan, A., Kerridge, I., Bradstock, K., Iland, H., et al (2015). A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia. Leukemia & Lymphoma, 56(5), 1406-1415. [More Information]
  • Iland, H., Collins, M., Bradstock, K., Supple, S., Catalano, A., Hertzberg, M., Browett, P., Grigg, A., Firkin, F., Campbell, L., et al (2015). Use of arsenic trioxide in remission induction and consolidation therapy for acute promyelocytic leukaemia in the Australasian Leukaemia and Lymphoma Group (ALLG) APML4 study: a non-randomised phase 2 trial. The Lancet Haematology, 2(9), e357-e366. [More Information]

2014

  • Hocking, J., Schwarer, A., Gasiorowski, R., Patil, S., Avery, S., Gibson, J., Iland, H., Ho, P., Joshua, D., Muirhead, J., et al (2014). Excellent outcomes for adolescents and adults with acute lymphoblastic leukemia and lymphoma without allogeneic stem cell transplant: the FRALLE-93 pediatric protocol. Leukemia & Lymphoma, 55(12), 2801-2807. [More Information]
  • Iland, H., Wei, A., Seymour, J. (2014). Have all-trans retinoic acid and arsenic trioxide replaced all-trans retinoic acid and anthracyclines in APL as standard of care. Best Practice & Research: Clinical Haematology, 27(1), 39-52. [More Information]
  • Iland, H., Seymour, J., Wei, A. (2014). Optimal approach for high-risk acute promyelocytic leukemia. Current Opinion In Hematology, 21(4), 102-113. [More Information]

2013

  • Firkin, F., Iland, H. (2013). Arsenic: an old enemy now turned friend. Leukemia & Lymphoma, 54(9), 1864-1866. [More Information]
  • Khoo, T., Catalano, A., Supple, S., Chong, L., Yeoh, S., Yeung, S., Iland, H. (2013). Hyperpigmentation of the hard palate associated with imatinib therapy for chronic myeloid leukemia with a genetic variation in the proto-oncogene c-KIT. Leukemia and Lymphoma, 54(1), 186-188. [More Information]
  • Gibson, J., Iland, H., Larsen, S., Brown, C., Joshua, D. (2013). Leukaemias into the 21st century - part 2: the chronic leukaemias. Internal Medicine Journal, 43(5), 484-494. [More Information]

2012

  • Iland, H., Bradstock, K., Supple, S., Catalano, A., Collins, M., Hertzberg, M., Browett, P., Grigg, A., Firkin, F., Hugman, A., et al (2012). All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4). Blood, 120(8), 1570-1580. [More Information]
  • Brown, C., Larsen, S., Iland, H., Joshua, D., Gibson, J. (2012). Leukaemias into the 21st century: part 1: the acute leukaemias. Internal Medicine Journal, 42(11), 1179-1186. [More Information]
  • Ling, S., Lau, K., Al-Shabeeb, A., Nikolic, A., Catalano, A., Iland, H., Horvath, N., Ho, P., Harrison, S., Fleming, S., Joshua, D., Allen, J. (2012). Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1. Haematologica, 97(1), 64-72. [More Information]

2009

  • de Zwaan, S., Iland, H., Damian, D. (2009). Treatment of refractory pyoderma gangrenosum with intravenous immunoglobulin. Australasian Journal of Dermatology, 50(1), 56-59. [More Information]

2007

  • Losco, P., Brown, R., Iland, H., Uhr, E., Lee, L., Joshua, D. (2007). An evaluation of the technical performance and clinical applications of the Beckman Coulter Access Erythropoietin immunoassay. Australian Journal of Medical Science, 28(4), 139-144.
  • Young, G., Iland, H. (2007). Clinical perspectives in lymphoma. Internal Medicine Journal, 37(7), 478-484. [More Information]
  • Sanders, J., Crawford, B., Gibson, J., Ho, P., Iland, H., Joshua, D. (2007). Is there a case for the early use of bisphosphonates in smouldering myeloma and MGUS? (Bisphosphonates in SMM & MGUS). International Journal of Laboratory Hematology, 29(5), 395-397. [More Information]

2006

  • Ling, S., Joshua, D., Gibson, J., Young, G., Iland, H., Watson, G., Ho, P. (2006). Transformation and Progression of Waldenström's Macroglobulinemia Following Cladribine Therapy in Two Cases: Natural Evolution or Iatrogenic Causation? American Journal Of Hematology, 81(2), 110-114. [More Information]

2005

  • Catalano, A., Iland, H. (2005). Molecular biology of lymphoma in the microarray era. Pathology, 37(6), 508-522. [More Information]
  • Iland, H., Hertzberg, M., Marlton, P. (2005). Myeloid Leukemia: Methods and Protocols. Humana Press.

2002

  • Applegate, T., Iland, H., Mokany, E., Todd, A. (2002). Diagnosis and molecular monitoring of acute promyelocytic leukemia using DzyNA reverse transcription-PCR to quantify PML/RAR alpha fusion transcripts. Clinical Chemistry, 48(8), 1338-1343. [More Information]
  • Stevenson, W., Vincent, P., Iland, H. (2002). Disseminated granulocytic sarcoma treated with allogeneic peripheral blood stem-cell transplantation. Leukemia and Lymphoma, 43(11), 2221-2224. [More Information]
  • Applegate, T., Iland, H., Mokany, E., Todd, A. (2002). Molecular monitoring of acute promyelocytic leukemia by DzyNA reverse transcription-PCR. Clinical Chemistry, 48(10), 1858-1860.

2001

  • Iland, H., Barnett, M., Pollard, J., Supple, S. (2001). A spontaneous novel XK gene mutation in a patient with McLeod syndrome. British Journal of Haematology, 115, 369-372.

2000

  • Iland, H. (2000). Detection of minimal residual disease in hematologic malignancies by molecular technology. In Kerry Atkinson (Eds.), Clinical Bone Marrow and Blood Stem Cell Transplantation, (pp. 1659-1675). New York, USA: Cambridge University Press.

Selected Grants

2008

  • A new Laser Microdissection Microscope with a unique pressure catapulting technique allows isolation of pure samples for subsequent downstream molecular analyses, Halliday G, Morris B, Mason R, Murphy C, Bishop A, Leamey C, Joshua D, Lee C, Iland H, Pamphlett R, Richardson D, King N, Hunt N, Arnold J, Morris M, Protti D, National Health and Medical Research Council (NHMRC)/Equipment Grant

2006

  • PHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer research, Assinder S, Bishop A, Conigrave A, Cook D, Dong Q, Grau G, Halliday G, Ho P, Hunt N, Iland H, Joshua D, King N, Lee C, Lovejoy D, Mason R, Murphy C, Reichardt J, Richardson D, Sharland A, Cancer Institute NSW/Infrastructure Grant