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Associate Professor Ingrid Gelissen
MAgSci (Nutrition); PhD
Associate Professor in Pharmaceutical Sciences
Research Education Academic Director, Sydney/Camperdown (Pharmacy/Concord)
Research Education Academic Director, Sydney/Camperdown (Pharmacy/Concord)
Phone
+61 2 86270357
Dr Gelissen initially completed a Masters in Nutrition at Wageningen University, the Netherlands. After working as a research associate for several years overseas and in Sydney, she completed her PhD degree at the Heart Research Institute, the University of Sydney, supported by an NH&MRC scholarship. Since graduating in 2000, she has completed post-doctoral positions at UT Southwestern in Dallas, Texas and the Centre for Vascular Research at the University of New South Wales in Sydney where she was awarded a prestigious Vice-Chancellors Post-doctoral Fellowship. She joined the School of Pharmacy as a Lecturer in 2010, was promoted to Senior Lecturer in 2014 and became an Associate Professor in 2020. In 2017, she was awarded a University of Sydney Thompson Fellowship to foster her research into the role of ABC transporter proteins in the setting of Alzheimers disease.
• The role of ABC-transporters in the export of amyloid-beta peptides from the brain.
Alzheimer’s disease (AD) is the most common form of dementia and is a large growing burden on our health system. A critical factor is the accumulation of amyloid-beta (Ab) peptides in the brain, which are toxic to neurons and impair synaptic function. The mechanism of export of Ab peptides from neurons and removal via efflux across the blood brain barrier (BBB) endothelium has been poorly elucidated. Several members of the ABC transporter family have been implicated in this process, including ABCB1 (better known as P-glycoprotein) and lipid transporters such as ABCG1 and ABCG4. The Gelissen lab has been interested in the regulation of ABC transporters in the brain and new mechanisms that may be exploited to enhance the export of Ab peptides from brain cells.
• Exploring the role of pharmacists in nutrition education.
Pharmacists are on the frontline in terms of health promotion and can play a valuable role in education their patients on aspects of disease prevention. Healthy diets and weight management provide the cornerstone for the prevention of non-communicable diseases such as cadiovascular disease and Type 2 diabetes. Together with collaborator, Dr Joanna Harnett, A/Prof Gelissen has an interest in exploring how pharmacists can promote healthy nutrition in addition to medication management for non-communicable diseases.
Teaching:
- Pharmacokinetics/pharmacogenomics
- Cardiovascular medicines
- Nutrition for pharmacy practice
- Cystic Fibrosis
Current HDR students:
1) Samar Elsayed: Nutrition in Pharmacy Practice
Selected publications
Cholesterol Homeostasis: Methods and Protocols
(Springer, 2017)
Publications
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Edited Books
- Gelissen, I., Brown, A. (2017). Cholesterol Homeostasis: Methods and Protocols. New York: Springer. [More Information]
Book Chapters
- Yang, A., Gelissen, I. (2017). ABC-transporter mediated sterol export from cells using radiolabeled sterols. In Ingrid C. Gelissen and Andrew J. Brown (Eds.), Cholesterol Homeostasis: Methods and Protocols, (pp. 275-285). New York: Springer. [More Information]
- Gelissen, I., Brown, A. (2017). An overview of cholesterol homeostasis. In Ingrid C. Gelissen and Andrew J. Brown (Eds.), Cholesterol Homeostasis: Methods and Protocols, (pp. 1-6). New York: Springer. [More Information]
- Luu, W., Gelissen, I., Brown, A. (2017). Manipulating cholesterol status within cells. In Ingrid C. Gelissen and Andrew J. Brown (Eds.), Cholesterol Homeostasis: Methods and Protocols, (pp. 41-52). New York: Springer. [More Information]
Journals
- Carter, C., Harnett, J., Krass, I., Gelissen, I. (2022). A review of primary healthcare practitioners' views about nutrition: implications for medical education. International Journal of Medical Education, 13, 124-137. [More Information]
- Carter, C., Harnett, J., Krass, I., Gelissen, I. (2022). Attitudes, behaviours, and self-reported confidence of Australian pharmacy students and interns towards nutritional counselling. Currents in Pharmacy Teaching and Learning, 14(11), 1411-1419. [More Information]
- Chai, A., Callaghan, R., Gelissen, I. (2022). Regulation of P-Glycoprotein in the Brain. International Journal of Molecular Sciences, 23(23). [More Information]
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Conferences
- Aslani, P., Tiao, D., Gelissen, I., Moles, R. (2011). A retrospective study on statin use in children and adolescents. Australasian Pharmaceutical Science Association (2011), Unkown: University Of South Australia.
- Tiao, D., Aslani, P., Gelissen, I., Moles, R. (2011). The use of statins in children with cholesterol disorders. Medicines Management 2011, the 37th Society of Hospital Pharmacists of Australia (SHPA) National Conference.
Expand all
2022
- Carter, C., Harnett, J., Krass, I., Gelissen, I. (2022). A review of primary healthcare practitioners' views about nutrition: implications for medical education. International Journal of Medical Education, 13, 124-137. [More Information]
- Carter, C., Harnett, J., Krass, I., Gelissen, I. (2022). Attitudes, behaviours, and self-reported confidence of Australian pharmacy students and interns towards nutritional counselling. Currents in Pharmacy Teaching and Learning, 14(11), 1411-1419. [More Information]
- Chai, A., Callaghan, R., Gelissen, I. (2022). Regulation of P-Glycoprotein in the Brain. International Journal of Molecular Sciences, 23(23). [More Information]
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2021
- Chai, A., Lam, H., Kockx, M., Gelissen, I. (2021). Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-beta. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866 (9), 158980. [More Information]
- Chong, R., Gelissen, I., Chaar, B., Penm, J., Cheung, J., Harnett, J. (2021). Do medicines commonly used by older adults impact their nutrient status? Exploratory Research in Clinical and Social Pharmacy, 3. [More Information]
- Kerr, I., Hutchison, E., Gerard, L., Aleidi, S., Gelissen, I. (2021). Mammalian ABCG-transporters, sterols and lipids: To bind perchance to transport? Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866 (3), 158860. [More Information]
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2020
- Callaghan, R., Gelissen, I., George, A., Hartz, A. (2020). Mamma Mia, P-glycoprotein binds again. FEBS Letters, 594(23), 4076-4084. [More Information]
- Chai, A., Leung, G., Callaghan, R., Gelissen, I. (2020). P-glycoprotein: A role in the export of amyloid-β in Alzheimer's disease? The FEBS Journal, 287(4), 612-625. [More Information]
- He, P., Gelissen, I., Ammit, A. (2020). Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and - independent signaling pathways with relevance to inflammatory lung disease. Respiratory Research, 21(1), 250. [More Information]
2019
- Alrosan, A., Aleidi, S., Yang, A., Brown, A., Gelissen, I. (2019). The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4. International Journal of Molecular Sciences, 20(11), 1-14. [More Information]
- He, P., Smith, A., Gelissen, I., Ammit, A. (2019). The effect of statins and the synthetic LXR agonist T0901317 on expression of ABCA1 transporter protein in human lung epithelial cell lines in vitro. Pharmacological Reports, 71(6), 1219-1226. [More Information]
2018
- Brown, A., Gelissen, I. (2018). Cholesterol and desmosterol dancing to the beat of a different drug. Journal of Internal Medicine, 283(1), 102-105. [More Information]
- Aleidi, S., Yang, A., Sharpe, L., Rao, G., Cochran, B., Rye, K., Kockx, M., Brown, A., Gelissen, I. (2018). The E3 ubiquitin ligase, HECTD1, is involved in ABCA1-mediated cholesterol export from macrophages. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (4), 359-368. [More Information]
2017
- Yang, A., Gelissen, I. (2017). ABC-transporter mediated sterol export from cells using radiolabeled sterols. In Ingrid C. Gelissen and Andrew J. Brown (Eds.), Cholesterol Homeostasis: Methods and Protocols, (pp. 275-285). New York: Springer. [More Information]
- Gelissen, I., Brown, A. (2017). An overview of cholesterol homeostasis. In Ingrid C. Gelissen and Andrew J. Brown (Eds.), Cholesterol Homeostasis: Methods and Protocols, (pp. 1-6). New York: Springer. [More Information]
- Gelissen, I., Brown, A. (2017). Cholesterol Homeostasis: Methods and Protocols. New York: Springer. [More Information]
show 3 more
2016
- Rumzhum, N., Patel, B., Prabhala, P., Gelissen, I., Oliver, B., Ammit, A. (2016). IL-17A increases TNF-(alpha)-induced COX-2 protein stability and augments PGE2 secretion from airway smooth muscle cells: impact on (beta)2 -adrenergic receptor desensitization. Allergy, 71(3), 387-396. [More Information]
- Luu, W., Sharpe, L., Capell-Hattam, I., Gelissen, I., Brown, A. (2016). Oxysterols: Old Tale, New Twists. Annual Review of Pharmacology and Toxicology, 56, 447-467. [More Information]
- Rahman, M., Prunte, L., Lebender, L., Patel, B., Gelissen, I., Hansbro, P., Morris, J., Clark, A., Verrills, N., Ammit, A. (2016). The phosphorylated form of FTY720 activates PP2A, represses inflammation and is devoid of S1P agonism in A549 lung epithelial cells. Scientific Reports, 6, 1-8. [More Information]
2015
- Sharpe, L., Rao, G., Jones, P., Glancey, E., Aleidi, S., George, A., Brown, A., Gelissen, I. (2015). Cholesterol sensing by the ABCG1 lipid transporter: Requirement of a CRAC motif in the final transmembrane domain. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1851 (7), 956-964. [More Information]
- Aleidi, S., Howe, V., Sharpe, L., Yang, A., Rao, G., Brown, A., Gelissen, I. (2015). The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters. Journal of Biological Chemistry, 290(40), 24604-24613. [More Information]
2014
- Olivier, M., Bott, R., Frisdal, E., Nowicki, M., Plengpanich, W., Desmarchelier, C., Roi, S., Quinn, C., Gelissen, I., Jessup, W., et al (2014). ABCG1 is involved in vitamin e efflux. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1841 (12), 1741-1751. [More Information]
- Hsieh, V., Kim, M., Gelissen, I., Brown, A., Sandoval, C., Hallab, J., Kockx, M., Traini, M., Jessup, W., Kritharides, L. (2014). Cellular Cholesterol Regulates Ubiquitination and Degradation of the Cholesterol Export Proteins ABCA1 and ABCG1. Journal of Biological Chemistry, 289(11), 7524-7536. [More Information]
- Gelissen, I., Nguyen, H., Tiao, D., Ayoub, R., Aslani, P., Moles, R. (2014). Statin Use in Australian Children: A Retrospective Audit of Four Pediatric Hospitals. Pediatric Drugs, 16(5), 417-423. [More Information]
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2013
- Burns, V., Sharpe, L., Gelissen, I., Brown, A. (2013). Species variation in ABCG1 isoform expression: Implications for the use of animal models in elucidating ABCG1 function. Atherosclerosis, 226(2), 408-411. [More Information]
- Luu, W., Sharpe, L., Gelissen, I., Brown, A. (2013). The Role of Signalling in Cellular Cholesterol Homeostasis. IUBMB Life, 65(8), 675-684. [More Information]
2012
- Gelissen, I., Brown, A. (2012). Predicting response to statins by pharmacogenetic testing. Pharmacogenomics, 13(11), 1223-1225. [More Information]
- Gelissen, I., Sharpe, L., Sandoval, C., Rao, G., Kockx, M., Kritharides, L., Jessup, W., Brown, A. (2012). Protein kinase A modulates the activity of a major human isoform of ABCG1. Journal of Lipid Research, 53(10), 2133-2140. [More Information]
2011
- Aslani, P., Tiao, D., Gelissen, I., Moles, R. (2011). A retrospective study on statin use in children and adolescents. Australasian Pharmaceutical Science Association (2011), Unkown: University Of South Australia.
- Gelissen, I., Brown, A. (2011). Drug targets beyond HMG-CoA reductase: Why venture beyond the statins? Frontiers in Biology, 6(3), 197-205. [More Information]
- Kerr, I., Haider, A., Gelissen, I. (2011). The ABCG family of membrane-associated transporters: you don't have to be big to be mighty. British Journal of Pharmacology, 164(7), 1767-1779. [More Information]
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2009
- Calabresi, L., Favari, E., Moleri, E., Adorni, M., Pedrelli, M., Costa, S., Jessup, W., Gelissen, I., Kovanen, P., Bernini, F., et al (2009). Functional LCAT is not required for macrophage cholesterol efflux to human serum. Atherosclerosis, 204(1), 141-146. [More Information]
2008
- Out, R., Jessup, W., Le Goff, W., Hoekstra, M., Gelissen, I., Zhao, Y., Kritharides, L., Chimini, G., Kuiper, J., Chapman, M., et al (2008). Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporter A1 and G1. Circulation Research, 102(1), 113-120. [More Information]
- Wong, J., Quinn, C., Gelissen, I., Jessup, W., Brown, A. (2008). The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation. Atherosclerosis, 196(1), 180-189. [More Information]
2007
- Wong, J., Quinn, C., Gelissen, I., Brown, A. (2007). Endogenous 24(S),25-Epoxycholesterol Fine-tunes Acute Control of Cellular Cholesterol Homeostasis. Journal of Biological Chemistry, 283, 700-707.
- Kim, W., Rahmanto, A., Kamili, A., Rye, K., Guillemin, G., Gelissen, I., Jessup, W., Hill, A., Garner, B. (2007). Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid- Peptide Generation. Journal of Biological Chemistry, 282, 2851-2861.
2005
- Glaros, E., Kim, W., Quinn, C., Wong, J., Gelissen, I., Jessup, W., Garner, B. (2005). Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. Journal of Biological Chemistry, 280, 24515-24523.
Selected Grants
2016
- Interaction of ABC transporters and amyloid-beta peptides in brain cells, Gelissen I, DVC Research/Thompson Fellowships
2011
- The use of Statins in Children - an audit of prescribing data from Australian Children's Hospitals, Moles R, Gelissen I, Aslani P, Society of Hospital Pharmacists of Australia/Research and Development Grants Program
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