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Dr Jaimie Polson

Lecturer, Physiology, School of Medical SciencesBosch Institute

Phone

+61 2 9351 4559

Email

jaimie.polson@sydney.edu.au

Hypertension (high blood pressure) is arguably the most important preventable risk factor for the development of early cardiovacular disease (according to organisations such as the National Heart Foundation of Australia, American Heart Association, World Heart Federation), and is reported to account directly for over 7.5 million death, worldwide, each year. My laboratory's interests are in determine the role that the brain plays in controlling blood pressure and does it play a role in the pathogenesis of hypertension?

What is the brain's role in blood pressure control? On possibility is in homeostatic regulation. The baroreceptor reflex plays a ruca role in refulating blood pressure. What happens to blood pressure in the olng term in the baroreceptors are faulty? Alternatively, how does psychological stressimpact on the risk of hypertension?

There is also increasing interest in the role that an adverse fetal environment may play in hypertension risk in the offspring in later life. For example, a poor diet during pregnancy can have devastating effects on offspring health. There is considerable evidence that very low calorie diets or diets low in protein lead to increased cardiovascular risk in the offspring. Morerecntly, high sugar and/or high fat diets during pregnancy have also been shown to increase risk of cardiovascular disease. Alternatively, taking medications or drugs during pregnancy has obvious risks, such as birth defects. But what about more subtle, or longer term consequences? How do you balance the health of the mother with the health of the baby?

One common factor seems to be exaggerated cardiovascular responses to stress.

I am also interested in the neural mechanisms underlying the cardiovascular (and respiratory) responses to exercise, which are poorly understood at present. In particular, the role of the hypothalamus in mediating these responses is known, but the details are vague.

We use a combination of physiological and anatomical techniques, in humans and rodents, to investigate these questions.

Themes

Obesity, Diabetes and Cardiovascular Disease, Neurosciences and Mental Health

Keywords

Autonomic nervous system, Cardiovascular diseases, Hypertension, Neurosciences, Physiology

Publications

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Journals

Dissanayake, H., McMullan, R., Kong, Y., Caterson, I., Celermajer, D., Phang, M., Raynes-Greenow, C., Polson, J., Gordon, A., Skilton, M. (2021). Cardiac and vascular health in late preterm infants (In Press). Journal of Developmental Origins of Health and Disease, 13(1), 128-134. [More Information]
Davis, E., Wald, H., Suarez, A., Zubcevic, J., Liu, C., Cortella, A., Kamitakahara, A., Polson, J., Arnold, M., Grill, H., et al (2020). Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve. Current Biology, 30(22), 4510-4518. [More Information]
Dissanayake, H., Anderson, L., McMullan, R., Caterson, I., Hyett, J., Phang, M., Raynes-Greenow, C., Polson, J., Skilton, M., Gordon, A. (2020). Influence of maternal and placental factors on newborn body composition. Journal of Paediatrics and Child Health, 56(2), 224-230. [More Information]
Dissanayake, H., Skilton, M., Polson, J. (2019). Autonomic dysfunction in programmed hypertension. Journal of Human Hypertension, 33(4), 267-276. [More Information]
Dissanayake, H., McMullan, R., Kong, Y., Caterson, I., Celermajer, D., Phang, M., Raynes-Greenow, C., Polson, J., Gordon, A., Skilton, M. (2018). Body Fatness and Cardiovascular Health in Newborn Infants. Journal of Clinical Medicine, 7(9), 1-12. [More Information]
Prestipino, L., Polson, J., Brolin, E., Ritchie, H. (2018). Long-term programming effects on blood pressure following gestational exposure to the IKr blocker Dofetilide. Physiological Reports, 6(5), 1-15. [More Information]
Dissanayake, H., McMullan, R., Gordon, A., Caterson, I., Celermajer, D., Phang, M., Raynes-Greenow, C., Skilton, M., Polson, J. (2018). Noninvasive assessment of autonomic function in human neonates born at the extremes of fetal growth spectrum. Physiological Reports, 6(8), e13682. [More Information]
Ritchie, H., Oakes, D., Kennedy, D., Polson, J. (2017). Early Gestational Hypoxia and Adverse Developmental Outcomes. Birth Defects Research, 109(17), 1358-1376. [More Information]
McKenzie, K., Dissanayake, H., McMullan, R., Caterson, I., Celermajer, D., Gordon, A., Hyett, J., Meroni, A., Phang, M., Raynes-Greenow, C., Polson, J., Skilton, M. (2017). Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk? Nutrients, 9(12), 1-12. [More Information]
Furlong, T., McDowall, L., Horiuchi, J., Polson, J., Dampney, R. (2014). The effect of air puff stress on c-Fos expression in rat hypothalamus and brainstem: central circuitry mediating sympathoexcitation and baroreflex resetting. European Journal of Neuroscience, 39(9), 1429-1438. [More Information]
Iigaya, K., Horiuchi, J., McDowall, L., Lam, A., Sediqi, Y., Polson, J., Carrive, P., Dampney, R. (2012). Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 303(10), R1011-R1022. [More Information]
Kenny, D., Polson, J., Martin, R., Paton, J., Wolf, A. (2011). Hypertension and coarctation of the aorta: an inevitable consequence of developmental pathophysiology. Hypertension Research, 34(5), 543-547. [More Information]
Kenny, D., Polson, J., Martin, R., Caputo, M., Wilson, D., Cockroft, J., Paton, J., Wolf, A. (2011). Relationship of aortic pulse wave velocity and baroreceptor reflex sensitivity to blood pressure control in patients with repaired coarctation of the aorta. American Heart Journal, 162(2), 398-404. [More Information]
Kenny, D., Polson, J., Martin, R., Wilson, D., Caputo, M., Cockcroft, J., Paton, J., Wolf, A. (2010). Surgical Approach for Aortic Coarctation Influences Arterial Compliance and Blood Pressure Control. Annals of Thoracic Surgery, 90(2), 600-604. [More Information]
Kenny, D., Polson, J., Martin, R., Paton, J., Wolf, A. (2009). Normalization of Autonomic Function in Children With Coarctation of the Aorta After Surgical Correction in Infancy. Hypertension, 54(3), e21-e22. [More Information]
Sun, C., Zubcevic, J., Polson, J., Potts, J., Diez-Freire, C., Zhang, Q., Paton, J., Raizada, M. (2009). Shift to an involvement of phosphatidylinositol 3-kinase in angiotensin ii actions on nucleus tractus solitarii neurons of the spontaneously hypertensive rat. Circulation Research, 105(12), 1248-1255. [More Information]
Waki, H., Shimizu, T., Yamasaki, M., Katahira, K., Katsuda, S., Polson, J., Maeda, M. (2008). Ramp rate of blood pressure changes does not affect aortic afferent sensitivity in anesthetized rats. Neuroscience Letters, 448(1), 37-40. [More Information]
Paton, J., Wang, S., Polson, J., Kasparov, S. (2008). Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension. Journal of Molecular Medicine, 86(6), 705-710. [More Information]
Polson, J., Dampney, R., Boscan, P., Pickering, A., Paton, J. (2007). Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 293(5), R1954-R1960. [More Information]
Waki, H., Katahira, K., Polson, J., Kasparov, S., Murphy, D., Paton, J. (2006). Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats. Experimental Physiology, 91(1), 201-213. [More Information]
Waki, H., Katahira, K., Polson, J., Kasparov, S., Murphy, D., Paton, J. (2006). Erratum: Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats (Experimental Physiology (2006) 91 (201-213)). Experimental Physiology, 91(2), 482-482. [More Information]
Polson, J., McCallion, N., Waki, H., Thorne, G., Tooley, M., Paton, J., Wolf, A. (2006). Evidence for Cardiovascular Autonomic Dysfunction in Neonates With Coarctation of the Aorta. Circulation, 113(24), 2844-2850. [More Information]
Marsh, A., Fontes, M., Killinger, S., Pawlak, D., Polson, J., Dampney, R. (2003). Cardiovascular responses evoked by Leptin acting on neurons in the ventromedial and dorsomedial hypothalamus. Hypertension, 42(4), 488-493. [More Information]
Dampney, R., Polson, J., Potts, P., Hirooka, Y., Horiuchi, J. (2003). Functional organization of brain pathways subserving the baroreceptor reflex: studies in conscious animals using the immediate early gene expression. Cellular and Molecular Neurobiology, 23(4/5), 597-616. [More Information]
Dampney, R., Horiuchi, J., Tagawa, T., Fontes, M., Potts, P., Polson, J. (2003). Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone. Acta Physiologica, 177(3), 209-218. [More Information]
Dampney, R., Coleman, M., Fontes, M., Hirooka, Y., Horiuchi, J., Li, Y., Polson, J., Potts, P., Tagawa, T. (2002). Central mechanisms underlying short and long term regulation of the cardiovascular system. Clinical and Experimental Pharmacology and Physiology, 29(4), 261-268. [More Information]
Polson, J., Mrljak, S., Potts, P., Dampney, R. (2002). Fos expression in spinally projecting neurons after hypotension in the conscious rabbit. Autonomic Neuroscience: Basic and Clinical, 100(1-2), 10-20. [More Information]
Fontes, M., Tagawa, T., Polson, J., Dampney, R., Cavanagh, S. (2001). Descending pathways mediating cardiovascular response from dorsomedial hypothalamic nucleus. American Journal of Physiology - Heart and Circulatory Physiology, 280(6), H2891-H2901.

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By Year

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2021

Dissanayake, H., McMullan, R., Kong, Y., Caterson, I., Celermajer, D., Phang, M., Raynes-Greenow, C., Polson, J., Gordon, A., Skilton, M. (2021). Cardiac and vascular health in late preterm infants (In Press). Journal of Developmental Origins of Health and Disease, 13(1), 128-134. [More Information]

2020

Davis, E., Wald, H., Suarez, A., Zubcevic, J., Liu, C., Cortella, A., Kamitakahara, A., Polson, J., Arnold, M., Grill, H., et al (2020). Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve. Current Biology, 30(22), 4510-4518. [More Information]
Dissanayake, H., Anderson, L., McMullan, R., Caterson, I., Hyett, J., Phang, M., Raynes-Greenow, C., Polson, J., Skilton, M., Gordon, A. (2020). Influence of maternal and placental factors on newborn body composition. Journal of Paediatrics and Child Health, 56(2), 224-230. [More Information]

2019

Dissanayake, H., Skilton, M., Polson, J. (2019). Autonomic dysfunction in programmed hypertension. Journal of Human Hypertension, 33(4), 267-276. [More Information]

2018

Dissanayake, H., McMullan, R., Kong, Y., Caterson, I., Celermajer, D., Phang, M., Raynes-Greenow, C., Polson, J., Gordon, A., Skilton, M. (2018). Body Fatness and Cardiovascular Health in Newborn Infants. Journal of Clinical Medicine, 7(9), 1-12. [More Information]
Prestipino, L., Polson, J., Brolin, E., Ritchie, H. (2018). Long-term programming effects on blood pressure following gestational exposure to the IKr blocker Dofetilide. Physiological Reports, 6(5), 1-15. [More Information]
Dissanayake, H., McMullan, R., Gordon, A., Caterson, I., Celermajer, D., Phang, M., Raynes-Greenow, C., Skilton, M., Polson, J. (2018). Noninvasive assessment of autonomic function in human neonates born at the extremes of fetal growth spectrum. Physiological Reports, 6(8), e13682. [More Information]

2017

Ritchie, H., Oakes, D., Kennedy, D., Polson, J. (2017). Early Gestational Hypoxia and Adverse Developmental Outcomes. Birth Defects Research, 109(17), 1358-1376. [More Information]
McKenzie, K., Dissanayake, H., McMullan, R., Caterson, I., Celermajer, D., Gordon, A., Hyett, J., Meroni, A., Phang, M., Raynes-Greenow, C., Polson, J., Skilton, M. (2017). Quantity and Quality of Carbohydrate Intake during Pregnancy, Newborn Body Fatness and Cardiac Autonomic Control: Conferred Cardiovascular Risk? Nutrients, 9(12), 1-12. [More Information]

2014

Furlong, T., McDowall, L., Horiuchi, J., Polson, J., Dampney, R. (2014). The effect of air puff stress on c-Fos expression in rat hypothalamus and brainstem: central circuitry mediating sympathoexcitation and baroreflex resetting. European Journal of Neuroscience, 39(9), 1429-1438. [More Information]

2012

Iigaya, K., Horiuchi, J., McDowall, L., Lam, A., Sediqi, Y., Polson, J., Carrive, P., Dampney, R. (2012). Blockade of orexin receptors with Almorexant reduces cardiorespiratory responses evoked from the hypothalamus but not baro- or chemoreceptor reflex responses. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 303(10), R1011-R1022. [More Information]

2011

Kenny, D., Polson, J., Martin, R., Paton, J., Wolf, A. (2011). Hypertension and coarctation of the aorta: an inevitable consequence of developmental pathophysiology. Hypertension Research, 34(5), 543-547. [More Information]
Kenny, D., Polson, J., Martin, R., Caputo, M., Wilson, D., Cockroft, J., Paton, J., Wolf, A. (2011). Relationship of aortic pulse wave velocity and baroreceptor reflex sensitivity to blood pressure control in patients with repaired coarctation of the aorta. American Heart Journal, 162(2), 398-404. [More Information]

2010

Kenny, D., Polson, J., Martin, R., Wilson, D., Caputo, M., Cockcroft, J., Paton, J., Wolf, A. (2010). Surgical Approach for Aortic Coarctation Influences Arterial Compliance and Blood Pressure Control. Annals of Thoracic Surgery, 90(2), 600-604. [More Information]

2009

Kenny, D., Polson, J., Martin, R., Paton, J., Wolf, A. (2009). Normalization of Autonomic Function in Children With Coarctation of the Aorta After Surgical Correction in Infancy. Hypertension, 54(3), e21-e22. [More Information]
Sun, C., Zubcevic, J., Polson, J., Potts, J., Diez-Freire, C., Zhang, Q., Paton, J., Raizada, M. (2009). Shift to an involvement of phosphatidylinositol 3-kinase in angiotensin ii actions on nucleus tractus solitarii neurons of the spontaneously hypertensive rat. Circulation Research, 105(12), 1248-1255. [More Information]

2008

Waki, H., Shimizu, T., Yamasaki, M., Katahira, K., Katsuda, S., Polson, J., Maeda, M. (2008). Ramp rate of blood pressure changes does not affect aortic afferent sensitivity in anesthetized rats. Neuroscience Letters, 448(1), 37-40. [More Information]
Paton, J., Wang, S., Polson, J., Kasparov, S. (2008). Signalling across the blood brain barrier by angiotensin II: novel implications for neurogenic hypertension. Journal of Molecular Medicine, 86(6), 705-710. [More Information]

2007

Polson, J., Dampney, R., Boscan, P., Pickering, A., Paton, J. (2007). Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 293(5), R1954-R1960. [More Information]

2006

Waki, H., Katahira, K., Polson, J., Kasparov, S., Murphy, D., Paton, J. (2006). Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats. Experimental Physiology, 91(1), 201-213. [More Information]
Waki, H., Katahira, K., Polson, J., Kasparov, S., Murphy, D., Paton, J. (2006). Erratum: Automation of analysis of cardiovascular autonomic function from chronic measurements of arterial pressure in conscious rats (Experimental Physiology (2006) 91 (201-213)). Experimental Physiology, 91(2), 482-482. [More Information]
Polson, J., McCallion, N., Waki, H., Thorne, G., Tooley, M., Paton, J., Wolf, A. (2006). Evidence for Cardiovascular Autonomic Dysfunction in Neonates With Coarctation of the Aorta. Circulation, 113(24), 2844-2850. [More Information]

2003

Marsh, A., Fontes, M., Killinger, S., Pawlak, D., Polson, J., Dampney, R. (2003). Cardiovascular responses evoked by Leptin acting on neurons in the ventromedial and dorsomedial hypothalamus. Hypertension, 42(4), 488-493. [More Information]
Dampney, R., Polson, J., Potts, P., Hirooka, Y., Horiuchi, J. (2003). Functional organization of brain pathways subserving the baroreceptor reflex: studies in conscious animals using the immediate early gene expression. Cellular and Molecular Neurobiology, 23(4/5), 597-616. [More Information]
Dampney, R., Horiuchi, J., Tagawa, T., Fontes, M., Potts, P., Polson, J. (2003). Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone. Acta Physiologica, 177(3), 209-218. [More Information]

2002

Dampney, R., Coleman, M., Fontes, M., Hirooka, Y., Horiuchi, J., Li, Y., Polson, J., Potts, P., Tagawa, T. (2002). Central mechanisms underlying short and long term regulation of the cardiovascular system. Clinical and Experimental Pharmacology and Physiology, 29(4), 261-268. [More Information]
Polson, J., Mrljak, S., Potts, P., Dampney, R. (2002). Fos expression in spinally projecting neurons after hypotension in the conscious rabbit. Autonomic Neuroscience: Basic and Clinical, 100(1-2), 10-20. [More Information]

2001

Fontes, M., Tagawa, T., Polson, J., Dampney, R., Cavanagh, S. (2001). Descending pathways mediating cardiovascular response from dorsomedial hypothalamic nucleus. American Journal of Physiology - Heart and Circulatory Physiology, 280(6), H2891-H2901.

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Dr Jaimie Polson

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