People_

Professor Jennifer Gamble

Wenkart Chair of Endothelium
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine &
Cell Biology

Phone

+61 2 9565 6225

Email

jennifer.gamble@sydney.edu.au

Details

Member of the Brain and Mind Centre

Biographical details

Professor Jennifer Gambleholds the inaugural, Wenkart Chair of the Endothelium, at the Centenary Institute and the University of Sydney.

Research interests

Professor Jennifer Gamble is an internationally recognized research leader in the field of endothelial cell function.

Her interests lie in understanding endothelial cell function particularly in the area of inflammation, and how dysfunction can influence disease. Her initial publication in this area established the endothelium as a dynamic organ, central to the control of inflammatory processes.

She is a Editor for Aging Cell and Senior Editor for Vascular Biology Journal.

She was a founding member of the Australian Vascular Biology Society.

She was recently Co-Chair of the World Congress on Inflammation, Sydney 2019

Current projects

The projects available for PhD, Masters and Honours students are:

the role of the aged vasculature in the initiation and development of disease

It has been said ' you are only as old as your blood vessels' . It is now appreciated that age is the greatest risk factor for disease. Thus the projests are focussed on understanding the impact of age on endothelial cell function and hence on disease. Our disease focus are:

Alzheimer's Disease,since one of the early changes in the brain of AD is the disruption of the blood brain barrier and in particular in the loss of the endothelial cell barrier integrity. This project will help us understand the consequences of the ageing process to the inflammatory response that is occuring in the brain. It will expose novel drug targets in the treatment of Alzheimer's Disease.

Calcific aortic valve disease (CAVD).

CAVD is the most common valvular heart disease in developed countries and the incidence of the disease increases with age.At present there are no drug therapies available for this disease and we have a limited understanding of the underlying molecular and cellular mechanisms of calcification that may help in the development of therapeutics. This project will investigate the role of the aged endothelium in CAVD.

Technologies.

Tissue culture assays, molecular and cellualr biology, high resolution imaging, animal models of disease, single cell RNAsequencing.

Themes

Obesity, Diabetes and Cardiovascular Disease, Neurosciences and Mental Health, Healthy Ageing

Keywords

Ageing, Alzheimer's disease, Cardiovascular diseases, Inflammation, Neurosciences

Approaches

Aged, Cellular Signalling, Cellular/Molecular

PhD and master's project opportunities

Understanding ageing of the endothelium

Diseases of the Aorta

MicroRNAs in disease

Understanding the role of novel genes in disease

Ageing Blood Vessels

Alzheimer’s Disease and Blood Vessels

Publications

By Type

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Book Chapters

Lichtenstein, I., Zomaya, A., Gamble, J., Vadas, M. (2011). Approaches to construction and analysis of microrna-mediated networks. In Mourad Elloumi, Albert Zomaya (Eds.), Algorithms in Computational Molecular Biology: Techniques, Approaches and Applications, (pp. 979-1006). Hoboken, New Jersey, USA: Wiley. [More Information]

Journals

Liu, X., Huang, Y., Liu, D., Jiang, Y., Zhao, M., Chung, L., Han, X., Zhao, Y., Chen, J., Coleman, P., Ting, K., Tran, C., Su, Y., Don, A., Vadas, M., Gorrell, M., Murray, M., Kavurma, M., McCaughan, G., Gamble, J., Qi, Y., et al (2024). Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Journal of Translational Medicine, 22(1), 43. [More Information]
Chen, J., Liu, K., Vadas, M., Gamble, J., McCaughan, G. (2024). The Role of the MiR-181 Family in Hepatocellular Carcinoma. Cells, 13(15). [More Information]
Coleman, P., Ting, K., Qi, J., Vadas, M., Gamble, J. (2023). Endothelial cell senescence — understanding aging and disease. Current Opinion in Physiology, 35, 100702. [More Information]
Liu, K., Chen, J., Zhao, Y., Boland, J., Ting, K., Lockwood, G., McKenzie, C., Kench, J., Vadas, M., Gamble, J., McCaughan, G. (2023). Novel miRNA-based drug CD5-2 reduces liver tumor growth in diethylnitrosamine-treated mice by normalizing tumor vasculature and altering immune infiltrate. Frontiers in Immunology, 14, 1245708. [More Information]
Vestweber, D., Claesson-Welsh, L., McDonald, D., Williams, T., Schwartz, M., Scallan, J., Gavins, F., van Buul, J., Gamble, J., Vadas, M., et al (2023). Report from the 2023 workshop on endothelial permeability, edema and inflammation. Nature Cardiovascular Research, 2(12), 1120-1124. [More Information]
Ting, K., Loo, L., Neely, G., Yang, P., Götz, J., Vadas, M., Gamble, J., Coleman, P., Kim, H., Zhao, Y., Johnstone, D., et al (2023). Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models. GeroScience, 45(6), 3307-3331. [More Information]
Liu, K., Dennis, C., Prince, D., Marsh-Wakefield, F., Santhakumar, C., Gamble, J., Strasser, S., McCaughan, G. (2023). Vessels that encapsulate tumour clusters vascular pattern in hepatocellular carcinoma. JHEP Reports, 5(8), 100792. [More Information]
Chen, J., Zhao, Y., Zhang, F., Li, J., Boland, J., Cheng, N., Liu, K., Tiffen, J., Bertolino, P., Bowen, D., Lisowski, L., Alexander, I., Vadas, M., Gamble, J., McCaughan, G., et al (2022). Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7. Cellular and Molecular Life Sciences, 79(8). [More Information]
Li, J., Zheng, M., Shimoni, O., Banks, W., Bush, A., Gamble, J., Shi, B. (2021). Development of Novel Therapeutics Targeting the Blood-Brain Barrier: From Barrier to Carrier. Advanced Science, 8(16), 2101090-1-2101090-27. [More Information]
Wong, W., Joglekar, M., Saini, V., Jiang, G., Dong, C., Chaitarvornkit, A., Maciag, G., Gerace, D., Farr, R., Satoor, S., Sahu, S., Sharangdhar, T., Ahmed, A., Chew, Y., Liuwantara, D., Hunter, J., Januszewski, A., Gamble, J., O'Connell, P., Hawthorne, W., et al (2021). Machine learning workflows identify a microRNA signature of insulin transcription in human tissues. iScience, 24(4), 102379. [More Information]
Ting, K., Coleman, P., Zhao, Y., Vadas, M., Gamble, J. (2021). The aging endothelium. Vascular Biology, 3(1), R35-R47. [More Information]
Zhao, Y., Ting, K., Coleman, P., Qi, J., Chen, J., Vadas, M., Gamble, J. (2021). The tumour vasculature as a target to modulate leucocyte trafficking. Cancers, 13(7), 1724. [More Information]
Zhao, Y., Li, J., Ting, K., Chen, J., Coleman, P., Liu, K., Wan, L., Moller, T., Vadas, M., Gamble, J. (2021). The VE-Cadherin/beta-catenin signalling axis regulates immune cell infiltration into tumours. Cancer Letters, 496, 1-15. [More Information]
Johansen, M., Irving, A., Montagutelli, X., Tate, M., Rudloff, I., Nold, M., Hansbro, N., Kim, R., Donovan, C., Liu, G., McCaughan, G., Gorrell, M., Cole, A., Moreno, C., Le Couteur, D., Hesselson, D., Triccas, J., Neely, G., Gamble, J., Simpson, S., et al (2020). Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology, 13(6), 877-891. [More Information]
Aji, G., Huang, Y., Ng, M., Wang, W., Lan, T., Li, M., Li, Y., Chen, Q., Li, R., Yan, S., Tran, C., Burchfield, J., Couttas, T., Chen, J., Chung, L., Liu, D., Wadham, C., Hogg, P., Vadas, M., Gamble, J., Don, A., Qi, J., et al (2020). Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2. Proceedings of the National Academy of Sciences of the United States of America, 117(39), 24434-24442. [More Information]
Li, J., Zhao, Y., Choi, J., Ting, K., Coleman, P., Chen, J., Cogger, V., Wan, L., Shi, Z., Moller, T., Zheng, X., Vadas, M., Gamble, J. (2020). Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice. PLoS Biology, 18(6), e3000734. [More Information]
Coleman, P., Lay, A., Ting, K., Zhao, Y., Li, J., Jarrah, R., Vadas, M., Gamble, J. (2020). YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment. Cell Communication and Signaling, 18(1), 18. [More Information]
Lay, A., Coleman, P., Formaz-Preston, A., Ting, K., Roediger, B., Weninger, W., Schwartz, M., Vadas, M., Gamble, J. (2019). ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis. Journal of the American Heart Association, 8(2), 1-15. [More Information]
Li, J., Zhao, Y., Coleman, P., Chen, J., Ting, K., Choi, J., Zheng, X., Vadas, M., Gamble, J. (2019). Low fluid shear stress conditions contribute to activation of cerebral cavernous malformation signalling pathways. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1865 (11), 1-13. [More Information]
Ting, K., Zhao, Y., Shen, W., Coleman, P., Yam, M., Chan-Ling, T., Li, J., Moller, T., Gillies, M., Vadas, M., Gamble, J. (2019). Therapeutic regulation of VE-cadherin with a novel oligonucleotide drug for diabetic eye complications using retinopathy mouse models. Diabetologia, 62(2), 322-334. [More Information]
Liu, R., Lo, L., Lay, A., Zhao, Y., Ting, K., Robertson, E., Sherrah, A., Jarrah, S., Li, H., Zhou, Z., Hambly, B., Jeremy, R., Bannon, P., Vadas, M., Gamble, J., et al (2017). ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Pro-Inflammatory Smooth Muscle Cell Phenotype. Circulation Research, 121(5), 512-524. [More Information]
McRobb, L., McKay, M., Gamble, J., Grace, M., Moutrie, V., Santos, E., Lee, V., Zhao, Z., Molloy, M., Stoodley, M. (2017). Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. Aging, 9(4), 1248-1268. [More Information]
Liu, K., Zhang, X., Xu, W., Chen, J., Yu, J., Gamble, J., McCaughan, G. (2017). Targeting the vasculature in hepatocellular carcinoma treatment: Starving versus normalizing blood supply. Clinical and Translational Gastroenterology, 8(6), 1-11. [More Information]
Zhao, Y., Ting, K., Li, J., Cogger, V., Chen, J., Johansson-Percival, A., Ngiow, S., Holst, J., Grau, G., Goel, S., McCaughan, G., Vadas, M., Gamble, J., et al (2017). Targeting vascular endothelial-cadherin in tumor-associated blood vessels promotes T-cell-mediated immunotherapy. Cancer Research, 77(16), 4434-4447. [More Information]
Lovelace, M., Powter, E., Coleman, P., Zhao, Y., Parker, A., Chang, G., Lay, A., Hunter, J., McGrath, A., Jormakka, M., Bertolino, P., McCaughan, G., Vadas, M., Gamble, J., et al (2017). The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells. Molecular Biology of the Cell, 28(8), 1066-1078. [More Information]
Chen, J., Wang, W., Qi, J., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARÃŽÂ³. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
Zhang, X., Gee, H., Rose, B., Lee, C., Clark, J., Elliott, M., Gamble, J., Cairns, M., Harris, A., Khoury, S., et al (2016). Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers. BMC Cancer, 16(1), 1-11. [More Information]
Li, J., Zhao, Y., Lu, Y., Ritchie, W., Grau, G., Vadas, M., Gamble, J. (2016). The Poly-cistronic miR-23-27-24 complexes target endothelial cell junctions: differential functional and molecular effects of miR-23a and miR-23b. Molecular Therapy - Nucleic Acids, 5(8), 1-12. [More Information]
Powter, E., Coleman, P., Tran, M., Lay, A., Bertolino, P., Parton, R., Vadas, M., Gamble, J. (2015). Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. Aging Cell, 14(1), 102-111. [More Information]
Brockhausen, J., Tay, S., Grzelak, C., Bertolino, P., Bowen, D., d'Avigdor, W., Teoh, N., Pok, S., Shackel, N., Gamble, J., Vadas, M., et al (2015). miR-181a mediates TGF-Î²-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer. Liver International, 35(1), 240-253. [More Information]
Sukocheva, O., Wadham, C., Gamble, J., Xia, P. (2015). Sphingosine-1-phosphate receptor 1 transmits estrogens' effects in endothelial cells. Steroids, 104, 237-245. [More Information]
Tay, S., Wong, Y., McDonald, D., Wood, N., Roediger, B., Sierro, F., McGuffog, C., Alexander, I., Bishop, A., Gamble, J., Weninger, W., McCaughan, G., Bertolino, P., Bowen, D. (2014). Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2540-E2549. [More Information]
Chang, G., Lay, A., Ting, K., Zhao, Y., Coleman, P., Powter, E., Formaz-Preston, A., Jolly, C., Bower, N., Hogan, B., Rinkwitz, S., Becker, T., Vadas, M., Gamble, J. (2014). ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. Small GTPases, 5(3), 1-15. [More Information]
Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]
Tay, S., Wong, Y., Roediger, B., Sierro, F., Lu, B., McDonald, D., McGuffog, C., Meyer, N., Alexander, I., Parish, I., Weninger, W., Bishop, A., Gamble, J., McCaughan, G., Bertolino, P., Bowen, D., et al (2014). Intrahepatic activation of naive CD4+T cells by liver-resident phagocytic cells. Journal of Immunology, 193(5), 2087-2095. [More Information]
Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
Lichtenstein, I., Charleston, M., Caetano, T., Gamble, J., Vadas, M. (2013). Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies. BMC Bioinformatics, 14, 1-22. [More Information]
Coleman, P., Chang, G., Hutas Attila, G., Grimshaw, M., Vadas, M., Gamble, J. (2013). Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging, 5(12), 913-924. [More Information]
Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]
Thickett, S., Moses, J., Gamble, J., Neto, C. (2012). Micropatterned substrates made by polymer bilayer dewetting and collagen nanoscale assembly support endothelial cell adhesion. Soft Matter, 8(39), 9996-10007. [More Information]
Nguyen, L., Jolly, L., Shoubridge, C., Chan, W., Huang, L., Laumonnier, F., Raynaud, M., Hackett, A., Field, M., Rodriguez, J., Gamble, J., et al (2012). Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Molecular Psychiatry, 17(11), 1103-1115. [More Information]
Gamble, J., Vadas, M., McCaughan, G. (2011). Sinusoidal endothelium is essential for liver regeneration. Hepatology, 54(2), 731-733. [More Information]
Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., Khew-Goodall, Y. (2010). A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration. Journal of Immunology, 185(5), 3057-3063. [More Information]
Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., Beck, K., Stocker, R., Vadas, M., Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. [More Information]
Zhang, X., Cairns, M., Rose, B., O'Brien, C., Shannon, K., Clark, J., Gamble, J., Tran, N. (2009). Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland. International Journal of Cancer, 124, 2855-2863. [More Information]
Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 424-441. [More Information]
Wu, B., Midwinter, R., Cassano, C., Beck, K., Wang, Y., Changsirivathanathamrong, D., Gamble, J., Stocker, R. (2009). Heme Oxygenase-1 Increases Endothelial Progenitor Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(10), 1537-1542. [More Information]
Gamble, J., Vadas, M. (2009). Insights into defibrotide as therapy for veno-occlusive disease. Hepatology, 49(2), 689-690. [More Information]
Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., Imhof, B., Vadas, M., Gamble, J. (2009). JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of beta 3 Integrins. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(8), 1200-1206. [More Information]
Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., Pitson, S., Lopez, A., Coates, P., Proia, R., Vadas, M., Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. [More Information]
Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., Bonder, C. (2009). Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. American Journal of Pathology, 175(5), 2217-2225. [More Information]
Limaye, V., Vadas, M., Pitson, S., Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 411-423. [More Information]
Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., Xia, P., Proia, R., Vadas, M., Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497. [More Information]
Vadas, M., Xia, P., McCaughan, G., Gamble, J. (2008). The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction? Biochimica et Biophysica Acta, 1781 (9), 442-447. [More Information]
Young, N., Hahn, C., Poh, A., Dong, C., Wilhelm, D., Olsson, J., Muscat, G., Parsons, P., Gamble, J., Koopman, P. (2006). Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. Journal of the National Cancer Institute, 98(15), 1060-1067. [More Information]
Cook-Johnson, R., Demasi, M., Cleland, L., Gamble, J., Saint, D., James, M. (2006). Endothelial cell COX-2 expression and activity in hypoxia. Biochimica et Biophysica Acta, 1761 (12), 1443-1449. [More Information]
Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. [More Information]
Wang, L., Xing, X., Holmes, A., Wadham, C., Gamble, J., Vadas, M., Xia, P. (2005). Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells. Circulation Research, 97, 891-899. [More Information]
Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., Yu, S., Kremmidiotis, G., Gardner, A., Solomon, P., Vadas, M., Gamble, J., et al (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(-), 57-69. [More Information]
Zannettino, A., Holding, C., Diamond, P., Atkins, G., Kostakis, P., Farrugia, A., Gamble, J., To, L., Findlay, D., Haynes, D. (2005). Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. Journal of Cellular Physiology, 204(2), 714-723. [More Information]
Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. [More Information]
Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., Kremmidiotis, G., Vadas, M., Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 101(33), 12212-12217. [More Information]
Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., Chatterjee, K., Vadas, M., Xia, P. (2004). PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase. Circulation Research, 94(11), 1515-1522. [More Information]
Li, X., Hahn, C., Parsons, M., Drew, J., Vadas, M., Gamble, J. (2004). Role of protein kinase CÎ¶ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood, 104(6), 1716-1724. [More Information]
Stein, B., Gamble, J., Pitson, S., Vadas, M., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. Journal of Immunology, 171(11), 6097-6104. [More Information]
Carr, J., Hocking, H., Bunting, K., Wright, P., Davidson, A., Gamble, J., Burrell, C., Li, P. (2003). Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers. Journal of Medical Virology, 69(4), 521-528. [More Information]
Wadham, C., Gamble, J., Vadas, M., Khew-Goodall, Y. (2003). The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates Î²-catenin. Molecular Biology of the Cell, 14(6), 2520-2529. [More Information]

show 64 more

Patents

Gamble, J., Vadas, M. (2020). Targeting microRNA as a Method of Regulating Angiogenesis. Patent No. 2010256284.
Gamble, J., Vadas, M. (2019). Modulation of RNA activity and vascular permeability. Patent No. 2013327393, 2904102, 6430945, 9879255, ZL201380061417.2. , China, France, Germany, Italy, Switzerland, United Kingdom.

By Year

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2024

Liu, X., Huang, Y., Liu, D., Jiang, Y., Zhao, M., Chung, L., Han, X., Zhao, Y., Chen, J., Coleman, P., Ting, K., Tran, C., Su, Y., Don, A., Vadas, M., Gorrell, M., Murray, M., Kavurma, M., McCaughan, G., Gamble, J., Qi, Y., et al (2024). Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Journal of Translational Medicine, 22(1), 43. [More Information]
Chen, J., Liu, K., Vadas, M., Gamble, J., McCaughan, G. (2024). The Role of the MiR-181 Family in Hepatocellular Carcinoma. Cells, 13(15). [More Information]

2023

Coleman, P., Ting, K., Qi, J., Vadas, M., Gamble, J. (2023). Endothelial cell senescence — understanding aging and disease. Current Opinion in Physiology, 35, 100702. [More Information]
Liu, K., Chen, J., Zhao, Y., Boland, J., Ting, K., Lockwood, G., McKenzie, C., Kench, J., Vadas, M., Gamble, J., McCaughan, G. (2023). Novel miRNA-based drug CD5-2 reduces liver tumor growth in diethylnitrosamine-treated mice by normalizing tumor vasculature and altering immune infiltrate. Frontiers in Immunology, 14, 1245708. [More Information]
Vestweber, D., Claesson-Welsh, L., McDonald, D., Williams, T., Schwartz, M., Scallan, J., Gavins, F., van Buul, J., Gamble, J., Vadas, M., et al (2023). Report from the 2023 workshop on endothelial permeability, edema and inflammation. Nature Cardiovascular Research, 2(12), 1120-1124. [More Information]
Ting, K., Loo, L., Neely, G., Yang, P., Götz, J., Vadas, M., Gamble, J., Coleman, P., Kim, H., Zhao, Y., Johnstone, D., et al (2023). Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models. GeroScience, 45(6), 3307-3331. [More Information]
Liu, K., Dennis, C., Prince, D., Marsh-Wakefield, F., Santhakumar, C., Gamble, J., Strasser, S., McCaughan, G. (2023). Vessels that encapsulate tumour clusters vascular pattern in hepatocellular carcinoma. JHEP Reports, 5(8), 100792. [More Information]

show 2 more

2022

Chen, J., Zhao, Y., Zhang, F., Li, J., Boland, J., Cheng, N., Liu, K., Tiffen, J., Bertolino, P., Bowen, D., Lisowski, L., Alexander, I., Vadas, M., Gamble, J., McCaughan, G., et al (2022). Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7. Cellular and Molecular Life Sciences, 79(8). [More Information]

2021

Li, J., Zheng, M., Shimoni, O., Banks, W., Bush, A., Gamble, J., Shi, B. (2021). Development of Novel Therapeutics Targeting the Blood-Brain Barrier: From Barrier to Carrier. Advanced Science, 8(16), 2101090-1-2101090-27. [More Information]
Wong, W., Joglekar, M., Saini, V., Jiang, G., Dong, C., Chaitarvornkit, A., Maciag, G., Gerace, D., Farr, R., Satoor, S., Sahu, S., Sharangdhar, T., Ahmed, A., Chew, Y., Liuwantara, D., Hunter, J., Januszewski, A., Gamble, J., O'Connell, P., Hawthorne, W., et al (2021). Machine learning workflows identify a microRNA signature of insulin transcription in human tissues. iScience, 24(4), 102379. [More Information]
Ting, K., Coleman, P., Zhao, Y., Vadas, M., Gamble, J. (2021). The aging endothelium. Vascular Biology, 3(1), R35-R47. [More Information]
Zhao, Y., Ting, K., Coleman, P., Qi, J., Chen, J., Vadas, M., Gamble, J. (2021). The tumour vasculature as a target to modulate leucocyte trafficking. Cancers, 13(7), 1724. [More Information]
Zhao, Y., Li, J., Ting, K., Chen, J., Coleman, P., Liu, K., Wan, L., Moller, T., Vadas, M., Gamble, J. (2021). The VE-Cadherin/beta-catenin signalling axis regulates immune cell infiltration into tumours. Cancer Letters, 496, 1-15. [More Information]

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2020

Johansen, M., Irving, A., Montagutelli, X., Tate, M., Rudloff, I., Nold, M., Hansbro, N., Kim, R., Donovan, C., Liu, G., McCaughan, G., Gorrell, M., Cole, A., Moreno, C., Le Couteur, D., Hesselson, D., Triccas, J., Neely, G., Gamble, J., Simpson, S., et al (2020). Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology, 13(6), 877-891. [More Information]
Aji, G., Huang, Y., Ng, M., Wang, W., Lan, T., Li, M., Li, Y., Chen, Q., Li, R., Yan, S., Tran, C., Burchfield, J., Couttas, T., Chen, J., Chung, L., Liu, D., Wadham, C., Hogg, P., Vadas, M., Gamble, J., Don, A., Qi, J., et al (2020). Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2. Proceedings of the National Academy of Sciences of the United States of America, 117(39), 24434-24442. [More Information]
Li, J., Zhao, Y., Choi, J., Ting, K., Coleman, P., Chen, J., Cogger, V., Wan, L., Shi, Z., Moller, T., Zheng, X., Vadas, M., Gamble, J. (2020). Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice. PLoS Biology, 18(6), e3000734. [More Information]
Gamble, J., Vadas, M. (2020). Targeting microRNA as a Method of Regulating Angiogenesis. Patent No. 2010256284.
Coleman, P., Lay, A., Ting, K., Zhao, Y., Li, J., Jarrah, R., Vadas, M., Gamble, J. (2020). YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment. Cell Communication and Signaling, 18(1), 18. [More Information]

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2019

Lay, A., Coleman, P., Formaz-Preston, A., Ting, K., Roediger, B., Weninger, W., Schwartz, M., Vadas, M., Gamble, J. (2019). ARHGAP18: A Flow-Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis. Journal of the American Heart Association, 8(2), 1-15. [More Information]
Li, J., Zhao, Y., Coleman, P., Chen, J., Ting, K., Choi, J., Zheng, X., Vadas, M., Gamble, J. (2019). Low fluid shear stress conditions contribute to activation of cerebral cavernous malformation signalling pathways. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1865 (11), 1-13. [More Information]
Gamble, J., Vadas, M. (2019). Modulation of RNA activity and vascular permeability. Patent No. 2013327393, 2904102, 6430945, 9879255, ZL201380061417.2. , China, France, Germany, Italy, Switzerland, United Kingdom.
Ting, K., Zhao, Y., Shen, W., Coleman, P., Yam, M., Chan-Ling, T., Li, J., Moller, T., Gillies, M., Vadas, M., Gamble, J. (2019). Therapeutic regulation of VE-cadherin with a novel oligonucleotide drug for diabetic eye complications using retinopathy mouse models. Diabetologia, 62(2), 322-334. [More Information]

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2017

Liu, R., Lo, L., Lay, A., Zhao, Y., Ting, K., Robertson, E., Sherrah, A., Jarrah, S., Li, H., Zhou, Z., Hambly, B., Jeremy, R., Bannon, P., Vadas, M., Gamble, J., et al (2017). ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Pro-Inflammatory Smooth Muscle Cell Phenotype. Circulation Research, 121(5), 512-524. [More Information]
McRobb, L., McKay, M., Gamble, J., Grace, M., Moutrie, V., Santos, E., Lee, V., Zhao, Z., Molloy, M., Stoodley, M. (2017). Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. Aging, 9(4), 1248-1268. [More Information]
Liu, K., Zhang, X., Xu, W., Chen, J., Yu, J., Gamble, J., McCaughan, G. (2017). Targeting the vasculature in hepatocellular carcinoma treatment: Starving versus normalizing blood supply. Clinical and Translational Gastroenterology, 8(6), 1-11. [More Information]
Zhao, Y., Ting, K., Li, J., Cogger, V., Chen, J., Johansson-Percival, A., Ngiow, S., Holst, J., Grau, G., Goel, S., McCaughan, G., Vadas, M., Gamble, J., et al (2017). Targeting vascular endothelial-cadherin in tumor-associated blood vessels promotes T-cell-mediated immunotherapy. Cancer Research, 77(16), 4434-4447. [More Information]
Lovelace, M., Powter, E., Coleman, P., Zhao, Y., Parker, A., Chang, G., Lay, A., Hunter, J., McGrath, A., Jormakka, M., Bertolino, P., McCaughan, G., Vadas, M., Gamble, J., et al (2017). The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells. Molecular Biology of the Cell, 28(8), 1066-1078. [More Information]

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2016

Chen, J., Wang, W., Qi, J., Kaczorowski, D., McCaughan, G., Gamble, J., Don, A., Gao, X., Vadas, M., Xia, P. (2016). Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARÃŽÂ³. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1861 (2), 138-147. [More Information]
Zhang, X., Gee, H., Rose, B., Lee, C., Clark, J., Elliott, M., Gamble, J., Cairns, M., Harris, A., Khoury, S., et al (2016). Regulation of the tumour suppressor PDCD4 by miR-499 and miR-21 in oropharyngeal cancers. BMC Cancer, 16(1), 1-11. [More Information]
Li, J., Zhao, Y., Lu, Y., Ritchie, W., Grau, G., Vadas, M., Gamble, J. (2016). The Poly-cistronic miR-23-27-24 complexes target endothelial cell junctions: differential functional and molecular effects of miR-23a and miR-23b. Molecular Therapy - Nucleic Acids, 5(8), 1-12. [More Information]

2015

Powter, E., Coleman, P., Tran, M., Lay, A., Bertolino, P., Parton, R., Vadas, M., Gamble, J. (2015). Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. Aging Cell, 14(1), 102-111. [More Information]
Brockhausen, J., Tay, S., Grzelak, C., Bertolino, P., Bowen, D., d'Avigdor, W., Teoh, N., Pok, S., Shackel, N., Gamble, J., Vadas, M., et al (2015). miR-181a mediates TGF-Î²-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer. Liver International, 35(1), 240-253. [More Information]
Sukocheva, O., Wadham, C., Gamble, J., Xia, P. (2015). Sphingosine-1-phosphate receptor 1 transmits estrogens' effects in endothelial cells. Steroids, 104, 237-245. [More Information]

2014

Tay, S., Wong, Y., McDonald, D., Wood, N., Roediger, B., Sierro, F., McGuffog, C., Alexander, I., Bishop, A., Gamble, J., Weninger, W., McCaughan, G., Bertolino, P., Bowen, D. (2014). Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2540-E2549. [More Information]
Chang, G., Lay, A., Ting, K., Zhao, Y., Coleman, P., Powter, E., Formaz-Preston, A., Jolly, C., Bower, N., Hogan, B., Rinkwitz, S., Becker, T., Vadas, M., Gamble, J. (2014). ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions. Small GTPases, 5(3), 1-15. [More Information]
Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]
Tay, S., Wong, Y., Roediger, B., Sierro, F., Lu, B., McDonald, D., McGuffog, C., Meyer, N., Alexander, I., Parish, I., Weninger, W., Bishop, A., Gamble, J., McCaughan, G., Bertolino, P., Bowen, D., et al (2014). Intrahepatic activation of naive CD4+T cells by liver-resident phagocytic cells. Journal of Immunology, 193(5), 2087-2095. [More Information]
Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]

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2013

Lichtenstein, I., Charleston, M., Caetano, T., Gamble, J., Vadas, M. (2013). Active subnetwork recovery with a mechanism-dependent scoring function; with application to angiogenesis and organogenesis studies. BMC Bioinformatics, 14, 1-22. [More Information]
Coleman, P., Chang, G., Hutas Attila, G., Grimshaw, M., Vadas, M., Gamble, J. (2013). Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells. Aging, 5(12), 913-924. [More Information]
Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]

2012

Thickett, S., Moses, J., Gamble, J., Neto, C. (2012). Micropatterned substrates made by polymer bilayer dewetting and collagen nanoscale assembly support endothelial cell adhesion. Soft Matter, 8(39), 9996-10007. [More Information]
Nguyen, L., Jolly, L., Shoubridge, C., Chan, W., Huang, L., Laumonnier, F., Raynaud, M., Hackett, A., Field, M., Rodriguez, J., Gamble, J., et al (2012). Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability. Molecular Psychiatry, 17(11), 1103-1115. [More Information]

2011

Lichtenstein, I., Zomaya, A., Gamble, J., Vadas, M. (2011). Approaches to construction and analysis of microrna-mediated networks. In Mourad Elloumi, Albert Zomaya (Eds.), Algorithms in Computational Molecular Biology: Techniques, Approaches and Applications, (pp. 979-1006). Hoboken, New Jersey, USA: Wiley. [More Information]
Gamble, J., Vadas, M., McCaughan, G. (2011). Sinusoidal endothelium is essential for liver regeneration. Hepatology, 54(2), 731-733. [More Information]

2010

Williams, S., Milne, I., Bagley, C., Gamble, J., Vadas, M., Pitson, S., Khew-Goodall, Y. (2010). A Proinflammatory Role for Proteolytically Cleaved Annexin A1 in Neutrophil Transendothelial Migration. Journal of Immunology, 185(5), 3057-3063. [More Information]
Coleman, P., Hahn, C., Grimshaw, M., Lu, Y., Li, X., Brautigan, P., Beck, K., Stocker, R., Vadas, M., Gamble, J. (2010). Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood, 116(19), 4016-4024. [More Information]

2009

Zhang, X., Cairns, M., Rose, B., O'Brien, C., Shannon, K., Clark, J., Gamble, J., Tran, N. (2009). Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland. International Journal of Cancer, 124, 2855-2863. [More Information]
Limaye, V., Xia, P., Hahn, C., Smith, M., Vadas, M., Pitson, S., Gamble, J. (2009). Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 424-441. [More Information]
Wu, B., Midwinter, R., Cassano, C., Beck, K., Wang, Y., Changsirivathanathamrong, D., Gamble, J., Stocker, R. (2009). Heme Oxygenase-1 Increases Endothelial Progenitor Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(10), 1537-1542. [More Information]
Gamble, J., Vadas, M. (2009). Insights into defibrotide as therapy for veno-occlusive disease. Hepatology, 49(2), 689-690. [More Information]
Li, X., Stankovic, M., Lee, B., Aurrand-Lions, M., Hahn, C., Lu, Y., Imhof, B., Vadas, M., Gamble, J. (2009). JAM-C Induces Endothelial Cell Permeability Through Its Association and Regulation of beta 3 Integrins. Arteriosclerosis, Thrombosis, and Vascular Biology, 29(8), 1200-1206. [More Information]
Bonder, C., Sun, W., Matthews, T., Cassano, C., Li, X., Ramshaw, H., Pitson, S., Lopez, A., Coates, P., Proia, R., Vadas, M., Gamble, J. (2009). Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation. Blood, 113(9), 2108-2117. [More Information]
Gamble, J., Sun, W., Li, X., Hahn, C., Pitson, S., Vadas, M., Bonder, C. (2009). Sphingosine kinase-1 associates with integrin {alpha}V{beta}3 to mediate endothelial cell survival. American Journal of Pathology, 175(5), 2217-2225. [More Information]
Limaye, V., Vadas, M., Pitson, S., Gamble, J. (2009). The effects of markedly raised intracellular sphingosine kinase-1 activity in endothelial cells. Cellular and Molecular Biology Letters, 14(3), 411-423. [More Information]

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2008

Li, X., Stankovic, M., Bonder, C., Hahn, C., Parsons, M., Pitson, S., Xia, P., Proia, R., Vadas, M., Gamble, J. (2008). Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. Blood, 111(7), 3489-3497. [More Information]
Vadas, M., Xia, P., McCaughan, G., Gamble, J. (2008). The role of sphingosine kinase 1 in cancer: Oncogene or non-oncogene addiction? Biochimica et Biophysica Acta, 1781 (9), 442-447. [More Information]

2006

Young, N., Hahn, C., Poh, A., Dong, C., Wilhelm, D., Olsson, J., Muscat, G., Parsons, P., Gamble, J., Koopman, P. (2006). Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development. Journal of the National Cancer Institute, 98(15), 1060-1067. [More Information]
Cook-Johnson, R., Demasi, M., Cleland, L., Gamble, J., Saint, D., James, M. (2006). Endothelial cell COX-2 expression and activity in hypoxia. Biochimica et Biophysica Acta, 1761 (12), 1443-1449. [More Information]
Gamble, J., Xia, P., Hahn, C., Drew, J., Drogemuller, C., Brown, D., Vadas, M. (2006). Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects. International Journal of Cancer, 118(10), 2412-2420. [More Information]

2005

Wang, L., Xing, X., Holmes, A., Wadham, C., Gamble, J., Vadas, M., Xia, P. (2005). Activation of the Sphingosine Kinase-Signaling Pathway by High Glucose Mediates the Proinflammatory Phenotype of Endothelial Cells. Circulation Research, 97, 891-899. [More Information]
Hahn, C., Su, Z., Drogemuller, C., Tsykin, A., Waterman, S., Brautigan, P., Yu, S., Kremmidiotis, G., Gardner, A., Solomon, P., Vadas, M., Gamble, J., et al (2005). Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis. Physiological Genomics, 22(-), 57-69. [More Information]
Zannettino, A., Holding, C., Diamond, P., Atkins, G., Kostakis, P., Farrugia, A., Gamble, J., To, L., Findlay, D., Haynes, D. (2005). Osteoprotegerin (OPG) is localized to the Weibel-Palade bodies of human vascular endothelial cells and is physically associated with von Willebrand factor. Journal of Cellular Physiology, 204(2), 714-723. [More Information]
Limaye, V., Li, X., Hahn, C., Xia, P., Berndt, M., Vadas, M., Gamble, J. (2005). Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members. Blood, 105(8), 3169-3177. [More Information]

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2004

Su, Z., Hahn, C., Goodall, G., Reck, N., Leske, A., Davy, A., Kremmidiotis, G., Vadas, M., Gamble, J. (2004). A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, 101(33), 12212-12217. [More Information]
Verrier, E., Wang, L., Wadham, C., Albanese, N., Hahn, C., Gamble, J., Chatterjee, K., Vadas, M., Xia, P. (2004). PPARgamma Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase. Circulation Research, 94(11), 1515-1522. [More Information]
Li, X., Hahn, C., Parsons, M., Drew, J., Vadas, M., Gamble, J. (2004). Role of protein kinase CÎ¶ in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1. Blood, 104(6), 1716-1724. [More Information]

2003

Stein, B., Gamble, J., Pitson, S., Vadas, M., Khew-Goodall, Y. (2003). Activation of Endothelial Extracellular Signal-Regulated Kinase Is Essential for Neutrophil Transmigration: Potential Involvement of a Soluble Neutrophil Factor in Endothelial Activation. Journal of Immunology, 171(11), 6097-6104. [More Information]
Carr, J., Hocking, H., Bunting, K., Wright, P., Davidson, A., Gamble, J., Burrell, C., Li, P. (2003). Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers. Journal of Medical Virology, 69(4), 521-528. [More Information]
Wadham, C., Gamble, J., Vadas, M., Khew-Goodall, Y. (2003). The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates Î²-catenin. Molecular Biology of the Cell, 14(6), 2520-2529. [More Information]

Selected Grants

2024

The Ageing Endothelium, Gamble J, NSW Health/Senior Researcher Grant

2021

New Strategies for Early Treatment of Alzheimers Disease, Gamble J, Ting K, Philip Bushell Foundation/Research Grant

2019

Endothelial Cell Senescence and Alzheimers Disease, Gamble J, Ting K, National Health and Medical Research Council (NHMRC)/Ideas Grant
Economic and versatile single-cell preparation system for shared use, in the Multi-Disciplinary Sydney Cytometry Facility. From Cancer to COVID-19., Gamble J, Wilmott J, Long G, National Health and Medical Research Council (NHMRC)/Equipment Grant
Therapeutic ultrasound for the treatment of brain disorders, Gamble J, Department of Health and Aged Care (Federal)/MRFF - Frontier Health and Medical Research Program, Stage One
Manipulation of the Ageing Endothelium, Gamble J, NSW Health/Cardiovascular Disease Senior Scientist Grants

2018

Real-time image-guided Optical Coherence Tomography 2 (OCT2), Gamble J, Johnstone D, Gillies M, National Health and Medical Research Council (NHMRC)/Equipment Grant

2017

Modulation of endothelial junctions as selective immunotherapy, Gamble J, Weninger W, National Health and Medical Research Council (NHMRC)/Project Grants

2016

Sensitizing tumours to immunotherapy: Development of an RNA-based therapeutic for pancreatic adenocarcinoma that targets the immunosuppressive tumour microenvironment, Gamble J, Vadas M, Biankin A, Begley C, National Health and Medical Research Council (NHMRC)/Development Grants
"Beyond the tape measure" - measuring the impact of abnormal flow dynamics on dilation of the ascending aorta, Grieve S, Bannon P, Bannon P, Jeremy R, Gamble J, Gamble J, Hambly B, Fletcher D, Liu R, National Health and Medical Research Council (NHMRC)/Project Grants

2015

A new therapy for pancreatic cancer that improves tumour microenvironment and immune cell penetration, Gamble J, Vadas M, PanKind Australian Pancreatic Cancer Foundation Ltd/Research support
Role of sphingolipid signalling in hepatic insulin resistance and its application in prediction of risk for type 2 diabetes and prediabetes, Vadas M, Gamble J, McCaughan G, Xia P, Gao X, Lin H, Xia M, National Health and Medical Research Council (NHMRC)/National Natural Science Foundation of China (NSFC)
Novel therapy approaches for diabetes and its liver and heart complications, Gorrell M, Keane F, Tu T, Shackel N, Bowen D, Bertolino P, Seth D, Chen J, Cook A, Liu R, Zheng X, Gamble J, McCaughan G, Rebecca L Cooper Medical Research Foundation/Research Support

2014

To support research Endothelium Vascular Biology Program , Gamble J, Sydney Medical School/Wenkart Accelerator Fund

2013

The immunomodulatory and angiogenic role of bone marrow-derived endothelial progenitor cells in chronic liver disease, Seth D, Haber P, McCaughan G, Gamble J, Duly A, Sarin S, Kaur S, Trehanpati N, Department of Industry, Science and Resources/Australia-India Strategic Research Fund (AISRF)
Normalisation of tumour angiogenic vessels by a novel miRNA inhibitor, Gamble J, Vadas M, University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding

2012

Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning, Gamble J, Feng C, McCaughan G, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M, National Health and Medical Research Council (NHMRC)/Equipment Grant

2011

miRNAs and Cardiovascular Disease, Gamble J, Vadas M, National Heart Foundation of Australia/Grants-in-Aid

2010

Senescence and Cardiovascular Disease, Gamble J, Vadas M, National Heart Foundation of Australia/Grants-in-Aid
Automated storage, retrieval, and UV imaging system, Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W, National Health and Medical Research Council (NHMRC)/Equipment Grant
High speed 3D live cell imaging of cancer genesis, growth, metastasis and death., Weninger W, Vadas M, Richardson D, Fazekas de St Groth B, Gamble J, McCaughan G, Rasko J, Shackel N, Haass N, Cancer Institute NSW/Equipment Grant

2009

Next-generation high-speed flow cytometric cell sorter, Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons J, Sword G, National Health and Medical Research Council (NHMRC)/Equipment Grant
New Surfaces for the Control of Endothelial Cell Function: Application in the Design of Biocompatible Stents, Neto C, Gamble J, Australian Research Council (ARC)/Discovery Projects (DP)
Inflammation, Angiogenesis and Cancer, Vadas M, McCaughan G, Gamble J, Bertolino P, Xia P, National Health and Medical Research Council (NHMRC)/Program Grants

2008

Inverted Multiphoton Intravital Microscope, Gorrell M, Weninger W, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N, National Health and Medical Research Council (NHMRC)/Equipment Grant
Multi-photon microscope for intravital imaging, Weninger W, Vadas M, Hogg P, Norris M, Fazekas de St Groth B, Haass N, Clarke S, Halliday G, Rasko J, Holst J, McCaughan G, Allen J, Gamble J, Dong Q, Byrne S, Richardson D, Cancer Institute NSW/Equipment Grant
How Age Influences Blood Vessel Function, Gamble J, Vadas M, National Heart Foundation of Australia/Grants-in-Aid
Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility, King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D, National Health and Medical Research Council (NHMRC)/Equipment Grant
Development of Inhibitors of PKCzeta for Targeting Vascular Leak, Gamble J, Parker M, Vadas M, Parker M, National Health and Medical Research Council (NHMRC)/Career Development Awards

2007

Sphingosine Kinase as a Key Regulator of Endothelial Permeability, Gamble J, National Heart Foundation of Australia/Grants-in-Aid FPRx139 SCHx351

Faculty of Medicine and Health

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Professor Jennifer Gamble

Publications

By Type

By Year

Selected Grants

2024

2021

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007