People_

Dr Jonathan Teo

Research Focused Academic
Sydney School of Medical Sciences
Faculty of Medicine and Health

Email

jonathan.teo@sydney.edu.au

Details

Member of The Centre for Drug Discovery Innovation

Member of the Charles Perkins Centre

Publications

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Journals

Al Halawani, A., Teo, J., Weiss, A., Yeo, G. (2024). The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging. Advanced Science, 11(39). [More Information]
Marian, O., Teo, J., Lee, J., Song, H., Kwok, J., Landin-Romero, R., Halliday, G., Don, A. (2023). Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations. Acta Neuropathologica Communications, 11(1), 52. [More Information]
Teo, J., Marian, O., Spiteri, A., Nicholson, M., Song, H., Khor, J., McEwen, H., Ge, A., Sen, M., Piccio, L., King, N., Don, A., et al (2023). Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. GLIA, 71(4), 1120-1141. [More Information]
Lee, J., Harney, D., Teo, J., Kwok, J., Sutherland, G., Larance, M., Don, A. (2023). The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus. Molecular Neurodegeneration, 18(1). [More Information]
Liu, X., Chung, L., Liu, D., Chen, J., Huang, Y., Teo, J., Han, X., Zhao, Y., Guan, F., Tran, C., Lee, J., Couttas, T., McCaughan, G., Gorrell, M., Don, A., Qi, Y., et al (2022). Ablation of sphingosine kinase 2 suppresses fatty liver- associated hepatocellular carcinoma via downregulation of ceramide transfer protein. Oncogenesis, 11(1), 1-12. [More Information]
Goodman, E., Mitchell, C., Teo, J., Gladding, J., Abbott, K., Rafiei, N., Zhang, L., Herzog, H., Begg, D. (2022). The effect of insulin receptor deletion in neuropeptide Y neurons on hippocampal dependent cognitive function in aging mice. Journal of Integrative Neuroscience, 21(1). [More Information]
Song, H., McEwen, H., Duncan, T., Lee, J., Teo, J., Don, A. (2021). Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication. GLIA, 69(12), 2863-2881. [More Information]
Couttas, T., Rustam, Y., Song, H., Qi, Y., Teo, J., Chen, J., Reid, G., Don, A. (2020). A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids. Metabolites, 10(6), 1-19. [More Information]
Tran, C., Heng, B., Teo, J., Humphrey, S., Qi, Y., Couttas, T., Stefen, H., Brettle, M., Fath, T., Guillemin, G., Don, A. (2020). Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes. Journal of Neurochemistry, 153(2), 173-188. [More Information]
Lei, M., Teo, J., Song, H., McEwen, H., Lee, J., Couttas, T., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., Don, A., et al (2019). Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease. Journal of Neuroscience, 39(48), 9645-9659. [More Information]
Turner, N., Lim, X., Toop, H., Osborne, B., Brandon, A., Taylor, E., Fiveash, C., Govindaraju, H., Teo, J., McEwen, H., Couttas, T., Cooney, G., Don, A., et al (2018). A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, 9(1). [More Information]
Teo, J., Morris, M., Jones, N. (2017). Hypoxic postconditioning improves behavioural deficits at 6 weeks following hypoxic-ischemic brain injury in neonatal rats. Behavioural Brain Research, 333, 27-34. [More Information]
Loh, K., Zhang, L., Brandon, A., Wang, K., Begg, D., Qi, Y., Fu, M., Kulkarni, R., Cooney, G., Teo, J., Neely, G., et al (2017). Insulin controls food intake and energy balance via NPY neurons. Molecular Metabolism, 6(6), 574-584. [More Information]
Teo, J., Morris, M., Jones, N. (2017). Maternal obesity increases inflammation and exacerbates damage following neonatal hypoxic-ischaemic brain injury in rats. Brain, Behavior, and Immunity, 63, 186-196. [More Information]
Teo, J., Morris, M., Jones, N. (2015). Hypoxic postconditioning reduces microglial activation, astrocyte and caspase activity, and inflammatory markers after hypoxia-ischemia in the neonatal rat brain. Pediatric Research: international journal of human developmental biology, 77(6), 757-764. [More Information]
Boyer, C., Teo, J., Phillips, P., Erlich, R., Sagnella, S., Sharbeen, G., Dwarte, T., Duong, H., Goldstein, D., Davis, T., et al (2013). Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers. Molecular Pharmaceutics, 10(6), 2435-2444. [More Information]

show 13 more

By Year

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2024

Al Halawani, A., Teo, J., Weiss, A., Yeo, G. (2024). The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging. Advanced Science, 11(39). [More Information]

2023

Marian, O., Teo, J., Lee, J., Song, H., Kwok, J., Landin-Romero, R., Halliday, G., Don, A. (2023). Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations. Acta Neuropathologica Communications, 11(1), 52. [More Information]
Teo, J., Marian, O., Spiteri, A., Nicholson, M., Song, H., Khor, J., McEwen, H., Ge, A., Sen, M., Piccio, L., King, N., Don, A., et al (2023). Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. GLIA, 71(4), 1120-1141. [More Information]
Lee, J., Harney, D., Teo, J., Kwok, J., Sutherland, G., Larance, M., Don, A. (2023). The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus. Molecular Neurodegeneration, 18(1). [More Information]

2022

Liu, X., Chung, L., Liu, D., Chen, J., Huang, Y., Teo, J., Han, X., Zhao, Y., Guan, F., Tran, C., Lee, J., Couttas, T., McCaughan, G., Gorrell, M., Don, A., Qi, Y., et al (2022). Ablation of sphingosine kinase 2 suppresses fatty liver- associated hepatocellular carcinoma via downregulation of ceramide transfer protein. Oncogenesis, 11(1), 1-12. [More Information]
Goodman, E., Mitchell, C., Teo, J., Gladding, J., Abbott, K., Rafiei, N., Zhang, L., Herzog, H., Begg, D. (2022). The effect of insulin receptor deletion in neuropeptide Y neurons on hippocampal dependent cognitive function in aging mice. Journal of Integrative Neuroscience, 21(1). [More Information]

2021

Song, H., McEwen, H., Duncan, T., Lee, J., Teo, J., Don, A. (2021). Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication. GLIA, 69(12), 2863-2881. [More Information]

2020

Couttas, T., Rustam, Y., Song, H., Qi, Y., Teo, J., Chen, J., Reid, G., Don, A. (2020). A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids. Metabolites, 10(6), 1-19. [More Information]
Tran, C., Heng, B., Teo, J., Humphrey, S., Qi, Y., Couttas, T., Stefen, H., Brettle, M., Fath, T., Guillemin, G., Don, A. (2020). Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes. Journal of Neurochemistry, 153(2), 173-188. [More Information]

2019

Lei, M., Teo, J., Song, H., McEwen, H., Lee, J., Couttas, T., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., Don, A., et al (2019). Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease. Journal of Neuroscience, 39(48), 9645-9659. [More Information]

2018

Turner, N., Lim, X., Toop, H., Osborne, B., Brandon, A., Taylor, E., Fiveash, C., Govindaraju, H., Teo, J., McEwen, H., Couttas, T., Cooney, G., Don, A., et al (2018). A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nature Communications, 9(1). [More Information]

2017

Teo, J., Morris, M., Jones, N. (2017). Hypoxic postconditioning improves behavioural deficits at 6 weeks following hypoxic-ischemic brain injury in neonatal rats. Behavioural Brain Research, 333, 27-34. [More Information]
Loh, K., Zhang, L., Brandon, A., Wang, K., Begg, D., Qi, Y., Fu, M., Kulkarni, R., Cooney, G., Teo, J., Neely, G., et al (2017). Insulin controls food intake and energy balance via NPY neurons. Molecular Metabolism, 6(6), 574-584. [More Information]
Teo, J., Morris, M., Jones, N. (2017). Maternal obesity increases inflammation and exacerbates damage following neonatal hypoxic-ischaemic brain injury in rats. Brain, Behavior, and Immunity, 63, 186-196. [More Information]

2015

Teo, J., Morris, M., Jones, N. (2015). Hypoxic postconditioning reduces microglial activation, astrocyte and caspase activity, and inflammatory markers after hypoxia-ischemia in the neonatal rat brain. Pediatric Research: international journal of human developmental biology, 77(6), 757-764. [More Information]

2013

Boyer, C., Teo, J., Phillips, P., Erlich, R., Sagnella, S., Sharbeen, G., Dwarte, T., Duong, H., Goldstein, D., Davis, T., et al (2013). Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers. Molecular Pharmaceutics, 10(6), 2435-2444. [More Information]

Selected Grants

2018