Mr Jose Perdomo
Sydney Medical School
Central Clinical School
Faculty of Medicine and Health
Dr Perdomo earned his PhD from the School of Molecular and Microbial Biosciences at the University of Sydney. He was subsequently awarded a Vice-Chancellor’s Fellowship, which led him to the Centre for Vascular Research at the University of New South Wales to explore gene regulation in cardiac and blood cells.
Dr Perdomo’s research focuses on endothelial damage caused by immune diseases and its impact on vascular health, with an emphasis on preventing thrombosis. He is developing targeted inhibitors to prevent formation of tissue damaging immune complexes. Techniques used include flow cytometry, microfluidics, confocal and intravital microscopy and platelet function assays.
See key recent papers and reviews:
- https://www.nature.com/articles/s41467-019-09160-7
- https://www.nature.com/articles/s41467-022-32946-1
- https://www.mdpi.com/2079-7737/12/10/1332
- https://doi.org/10.1182/bloodadvances.2024013883
Patents:
The role of endothelial cells in thrombosis and inflammation
Publications
Journals
- Leung, H., Perdomo, J., Ahmadi, Z., Chong, B. (2023). Determination of Antibody Activity by Platelet Aggregation. Bio-protocol, 13(17). [More Information]
- Perdomo, J., Leung, H. (2023). Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis. Biology, 12(10). [More Information]
- Zheng, S., Ahmadi, Z., Leung, H., Wong, R., Yan, F., Perdomo, J., Chong, B. (2022). Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia. Haematologica, 107(9), 2195-2205. [More Information]
2023
- Leung, H., Perdomo, J., Ahmadi, Z., Chong, B. (2023). Determination of Antibody Activity by Platelet Aggregation. Bio-protocol, 13(17). [More Information]
- Perdomo, J., Leung, H. (2023). Immune Thrombosis: Exploring the Significance of Immune Complexes and NETosis. Biology, 12(10). [More Information]
2022
- Zheng, S., Ahmadi, Z., Leung, H., Wong, R., Yan, F., Perdomo, J., Chong, B. (2022). Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia. Haematologica, 107(9), 2195-2205. [More Information]
- Chilingaryan, Z., Deshmukh, T., Leung, H., Perdomo, J., Emerson, P., Kurup, R., Chong, B., Chong, J. (2022). Erythrocyte interaction with neutrophil extracellular traps in coronary artery thrombosis following myocardial infarction. Pathology, 54(1), 87-94. [More Information]
- Leung, H., Perdomo, J., Ahmadi, Z., Zheng, S., Rashid, F., Enjeti, A., Ting, S., Chong, J., Chong, B. (2022). NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia. Nature Communications, 13(1). [More Information]
2021
- Zheng, S., Perdomo, J., Ahmadi, Z., Chong, B. (2021). Indirect detection of anti-platelet antibodies in immune thrombocytopenia. Pathology, 53(6), 759-762. [More Information]
- Leung, H., Perdomo, J., Ahmadi, Z., Yan, F., McKenzie, S., Chong, B. (2021). Inhibition of NADPH oxidase blocks NETosis and reduces thrombosis in heparin-induced thrombocytopenia. Blood Advances, 5(23), 5439-5451. [More Information]
- Rashid, F., Clayton, Z., Ogawa, M., Perdomo, J., Hume, R., Kizana, E., Chong, J. (2021). Platelet derived growth factor-A (Pdgf-a) gene transfer modulates scar composition and improves left ventricular function after myocardial infarction. International Journal of Cardiology, 341, 24-30. [More Information]
2020
- Zheng, S., Perdomo, J., Leung, H., Yan, F., Chong, B. (2020). Acquired Glanzmann thrombasthenia associated with platelet desialylation. Journal of Thrombosis and Haemostasis, 18(3), 714-721. [More Information]
2019
- Ahmadi, Z., Perdomo, J., Wong, R., Chong, B. (2019). Drug-induced immune thrombocytopenia: Mapping of the drug binding site to the membrane-proximal region of platelet GPIX. Platelets, 30(2), 251-255. [More Information]
- Perdomo, J., Leung, H., Ahmadi, Z., Yan, F., Chong, J., Passam, F., Chong, B. (2019). Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia. Nature Communications, 10(1), 1-14. [More Information]
2017
- Perdomo, J., Yan, F., Leung, H., Chong, B. (2017). Megakaryocyte differentiation and platelet formation from human cord blood-derived CD34+ cells. Journal of Visualized Experiments, 2017 (130). [More Information]
2016
- Perdomo, J. (2016). Role of romiplostim in splenectomized and nonsplenectomized patients with immune thrombocytopenia. ImmunoTargets and Therapy, 5, 1-7. [More Information]
2015
- Iraqi, M., Perdomo, J., Yan, F., Young-Ill Choi, P., Chong, B. (2015). Immune thrombocytopenia: Antiplatelet autoantibodies inhibit proplatelet formation by megakaryocytes and impair platelet production in vitro. Haematologica, 100(5), 623-632. [More Information]
2014
- Carter, D., Buckle, A., Tanaka, K., Perdomo, J., Chong, B. (2014). Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes. PloS One, 9(4). [More Information]
2013
- Perdomo, J., Yan, F., Chong, B. (2013). A megakaryocyte with no platelets: Anti-platelet antibodies, apoptosis, and platelet production. Platelets, 24(2), 98-106. [More Information]
- Chong, B., Young-Ill Choi, P., Khachigian, L., Perdomo, J. (2013). Drug-induced immune thrombocytopenia. Hematology-Oncology Clinics of North America, 27(3), 521-540. [More Information]
2012
- Funnell, A., Norton, L., Mak, K., Burdach, J., Artuz, C., Twine, N., Wilkins, M., Power, C., Hung, T., Perdomo, J., Bell-Anderson, K., Fraser, S., et al (2012). The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo. Molecular and Cellular Biology, 32(16), 3281-3292. [More Information]
2011
- Perdomo, J., Yan, F., Ahmadi, Z., Jiang, X., Stocker, R., Chong, B. (2011). Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro. Blood, 117(22), 5975-5986. [More Information]
2006
- Quinlan (nee Edwards), K., Verger, A., Kwok, A., Lee, S., Perdomo, J., Nardini, M., Bolognesi, M., Crossley, P. (2006). Role of the C-Terminal Binding Protein PXDLS Motif Binding Cleft in Protein Interactions and Transcriptional Repression. Molecular and Cellular Biology, 26(21), 8202-8213. [More Information]
2005
- Perdomo, J., Verger, A., Turner, J., Crossley, P. (2005). Role for SUMO modification in facilitating transcriptional repression by BKLF. Molecular and Cellular Biology, 25(4), 1549-1559. [More Information]
2004
- Westman, B., Perdomo, J., Matthews, J., Crossley, P., Mackay, J. (2004). Structural Studies On A Protein-Binding Zinc-Finger Domain Of Eos Reveal Both Similarities And Differences To Classical Zinc Fingers. Biochemistry, 43(42), 13318-13327.
2003
- Verger, A., Perdomo, J., Crossley, P. (2003). Modification with SUMO: A role in transcriptional regulation. EMBO Reports, 4(2), 137-142. [More Information]
- Westman, B., Perdomo, J., Sunde, M., Crossley, P., Mackay, J. (2003). The C-terminal domain fo Eos forms a high order complex in solution. Journal of Biological Chemistry, 278(43), 42419-42426. [More Information]
2002
- Perdomo, J., Crossley, P. (2002). The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. FEBS Journal, 269(23), 5885-5892. [More Information]
In the media
AstraZeneca blood clotting: what is this rare syndrome and how is it caused? (https://www.theguardian.com/world/2021/apr/13/astrazeneca-blood-clotting-what-is-this-rare-syndrome-and-how-is-it-caused)
What we know so far about blood clots linked to AstraZeneca vaccine
Astrazeneca vaccine why are under 50s more at risk of blood, 7News, April 2021 https://7news.com.au/lifestyle/health-wellbeing/astrazeneca-vaccine-why-are-under-50s-more-at-risk-of-blood-clot-than-over-50s-c-2545702
Explainer: How come some AstraZeneca vaccine recipients develop blood clots (https://www.canberratimes.com.au/story/7209339/how-come-some-astrazeneca-vaccine-recipients-develop-blood-clots/)
How might the AstraZeneca COVID-19 vaccine cause blood clots? We ask the experts (https://www.abc.net.au/news/health/2021-04-22/covid-19-astrazeneca-vaccine-how-might-it-case-blood-clots/100079276)