People_

Dr Kaitao Lai

Computational Biologist, Honorary Lecturer, Transplant Genomics Group, Centre for Transplant and Renal Research, Westmead Institute for Medical Research

Websites

Google Scholar

ORCID

Biographical details

Dr Kaitao Lai has extensive experience in computational biology and bioinformatics from multiple disciplines. He is a post-doctoral researcher with the Transplant Genomics Group, Centre for Transplant and Renal Research at Westmead Institute for Medical Research, Faculty of Medicine and Health, University of Sydney.

Research interests

Bioinformatics, Structural variation, Genetic variation, Metagenomics, Machine learning

Current projects

Project: Advancing Kidney Transplant Outcomes through Precision Medicine: A Genomics Approach

This groundbreaking research project, led by Westmead Institute for Medical Research (WIMR) under the direction of Professor Philip O’Connell and supported by a $2.474 million grant from the Medical Research Future Fund (MRFF) Genomics Health Futures Mission, aims to revolutionize kidney transplantation outcomes. By developing and validating a genetic risk score for kidney transplantation, the project seeks to identify patients at risk of acute rejection and long-term graft loss at the time of transplantation. Leveraging large multi-ethnic databases to understand the impact of genetic variation on transplant survival, this initiative embodies the precision medicine approach. It focuses on tailoring treatment strategies to individual genetic profiles to enhance the success rates of transplants, address the critical challenge of improving long-term graft survival, and significantly impact patient care globally.

Awards and honours

AGTA2019 (Melbourne) Travel Awards by Australian Genomic Technologies Association Annual Conference 2019, Oct 2019

H&B Award 2017 for Outstanding Collaboration by Health & Biosecurity Unit, CSIRO, Dec 2017

AGTA2017 (Hobart) Travel Awards by Australian Genomic Technologies Association Annual Conference 2017, Nov 2017

Grains Research & Development Corporation (GRDC) Travel Awards for the Plant and Animal Genome (PAG) XXI conference, Sep 2012

The 2012 School of Agriculture and Food Science (SAFS) RHD Travel Awards for the Plant and Animal Genome (PAG) XXI conference, Sep 2012

Australian Postgraduate Award Industry (APAI) scholarship by Australian Research Council (ARC), Jul 2010-Jun 2013

Themes

Cancer

Keywords

Bioinformatics, Cancer, Genetic diseases, Mutation

Approaches

Genetics

Publications

By Type

Expand all

Book Chapters

Lai, K., Twine, N., O'Brien, A., Guo, Y., Bauer, D. (2019). Artificial Intelligence and Machine Learning in Bioinformatics. In S. Raganathan, M. Gribskov, K. Nakai. C. Schonbach (Eds.), Encyclopedia of Bioinformatics and Computational Biology, (pp. 272-286). United States of America: Elsevier. [More Information]
Lai, K. (2016). WheatGenome. info: A Resource for Wheat Genomics Resource. In David Edwards (Eds.), Plan Bioinformatics - Methods and Protocols (Second Edition), (pp. 203-213). New york: Humana Press. [More Information]
Lai, K., Lorenc, M., Edwards, D. (2015). Molecular Marker Databases. In Jacqueline Batley (Eds.), Plant Genotyping: Methods and Protocols, (pp. 49-62). New York: Springer. [More Information]

Journals

Cutrupi, A., Narayanan, R., Perez-Siles, G., Grosz, B., Lai, K., Boyling, A., Ellis, M., Lin, R., Neumann, B., Mao, D., Nicholson, G., Vucic, S., Kennerson, M., et al (2023). Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. Brain, 146(3), 880-897. [More Information]
Huo, Y., Yang, D., Lai, K., Tu, J., Zhu, Y., Ding, W., Yang, S. (2022). Antioxidant Effects of Resveratrol in Intervertebral Disk. Journal of Investigative Surgery, 35(5), 1135-1144. [More Information]
Li, W., Lai, K., Chopra, N., Zheng, Z., Das, A., Diwan, A. (2022). Gut-disc axis: A cause of intervertebral disc degeneration and low back pain? European Spine Journal, 31(4), 917-925. [More Information]
Tu, J., Li, W., Yang, S., Yang, P., Yan, Q., Wang, S., Lai, K., Bai, X., Wu, C., Ding, W., et al (2022). Single-Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression. Advanced Science, 9(3), 2103631. [More Information]
Tavana, N., Ting, T., Lai, K., Kennerson, M., Thilakavathy, K. (2022). Whole exome sequencing identifies two novel variants in PHEX and DMP1 in Malaysian children with hypophosphatemic rickets. The Italian Journal of Pediatrics (Print), 48(1). [More Information]
Gonzalez-Rajal, A., Marzec, K., McCloy, R., Nobis, M., Chin, V., Hastings, J., Lai, K., Kennerson, M., Hughes, W., Vaghjiani, V., Burgess, A., et al (2021). A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma. eLife, 10, 1-28. [More Information]
Johnson, T., Schelch, K., Lai, K., Marzec, K., Kennerson, M., Grusch, M., Reid, G., Burgess, A. (2020). YB-1 knockdown inhibits the proliferation of mesothelioma cells through multiple mechanisms. Cancers, 12(8), 1-21. [More Information]
Abadir, E., Gasiorowski, R., Lai, K., Kupresanin, F., Romano, A., Silveira, P., Lo, T., Fromm, P., Kennerson, M., Iland, H., Ho, P., Hart, D., Clark, G., et al (2019). CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation. Molecular Oncology, 13(10), 2107-2120. [More Information]
Jeffries, T., Rayu, S., Nielsen, U., Lai, K., Ijaz, A., Nazaries, L., Singh, B. (2018). Metagenomic Functional Potential Predicts Degradation Rates of a Model Organophosphorus Xenobiotic in Pesticide Contaminated Soils. Frontiers in Microbiology, 9(February), 147. [More Information]
Li, J., Lin, J., Pei, C., Lai, K., Jeffries, T., Tang, G. (2018). Variation of soil bacterial communities along a chronosequence of Eucalyptus plantation. PeerJ, 6, e5648. [More Information]
Trivedi, P., Delgado-Baquerizo, M., Jeffries, T., Trivedi, C., Anderson, I., Lai, K., McNee, M., Flower, K., Singh, B., Minkey, D., et al (2017). Soil aggregation and associated microbial communities modify the impact of agricultural management on carbon content. Environmental Microbiology, 19(8), 3070-3086. [More Information]
Montenegro, J., Golicz, A., Bayer, P., Hurgobin, B., Lee, H., Chan, C., Visendi, P., Lai, K., Dolezel, J., Batley, J., et al (2017). The pangenome of hexaploid bread wheat. Plant Journal, 90(5), 1007-1013. [More Information]
Lai, K., Lorenc, M., Lee, H., Berkman, P., Bayer, P., Visendi, P., Ruperao, P., Fitzgerald, T., Zander, M., Chan, C., et al (2015). Identification and characterization of more than 4 million intervarietal SNPs across the group 7 chromosomes of bread wheat. Plant Biotechnology Journal, 13(1), 97-104. [More Information]
Zander, M., Patel, D., Van de Wouw, A., Lai, K., Lorenc, M., Campbell, E., Hayward, A., Edwards, D., Raman, H., Batley, J. (2013). Identifying genetic diversity of avirulence genes in Leptosphaeria maculans using whole genome sequencing. Functional and Integrative Genomics, 13(3), 295-308. [More Information]
Lee, H., Lai, K., Lorenc, M., Imelfort, M., Duran, C., Edwards, D. (2012). Bioinformatics tools and databases for analysis of next-generation sequence data. Briefings in Functional Genomics, 11(1), 12-24. [More Information]
Lorenc, M., Hayashi, S., Stiller, J., Lee, H., Manoli, S., Ruperao, P., Visendi, P., Berkman, P., Lai, K., Batley, J., et al (2012). Discovery of Single Nucleotide Polymorphisms in Complex Genomes Using SGSautoSNP. Biology, 1(2), 370-382. [More Information]
Berkman, P., Lai, K., Lorenc, M., Edwards, D. (2012). Next-generation sequencing applications for wheat crop improvement. American Journal of Botany, 99(2), 365-371. [More Information]
Berkman, P., Skarshewski, A., Manoli, S., Lorenc, M., Stiller, J., Smits, L., Lai, K., Campbell, E., Kubalakova, M., Simkova, H., et al (2012). Sequencing wheat chromosome arm 7BS delimits the 7BS/4AL translocation and reveals homoeologous gene conservation. Theoretical and Applied Genetics, 124(3), 423-432. [More Information]
Lai, K., Berkman, P., Duran, C., Lorenc, M., Stiller, J., Manoli, S., Hayden, M., Forrest, K., Fleury, D., Baumann, U., et al (2012). Single nucleotide polymorphism discovery from wheat next-generation sequence data. Plant Biotechnology Journal, 10(6), 743-749. [More Information]
Lai, K., Berkman, P., Lorenc, M., Duran, C., Smits, L., Manoli, S., Stiller, J., Edwards, D. (2012). WheatGenomeinfo: an integrated database and portal for wheat genome information. Plant and Cell Physiology, 53(2), 1-7. [More Information]
Berkman, P., Skarshewski, A., Lorenc, M., Lai, K., Duran, C., Ling, E., Stiller, J., Smits, L., Imelfort, M., Manoli, S., et al (2011). Sequencing and assembly of low copy and genic regions of isolated Triticum aestivum chromosome arm 7DS. Plant Biotechnology Journal, 9(7), 768-775. [More Information]

show 18 more

By Year

Expand all

2023

Cutrupi, A., Narayanan, R., Perez-Siles, G., Grosz, B., Lai, K., Boyling, A., Ellis, M., Lin, R., Neumann, B., Mao, D., Nicholson, G., Vucic, S., Kennerson, M., et al (2023). Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. Brain, 146(3), 880-897. [More Information]

2022

Huo, Y., Yang, D., Lai, K., Tu, J., Zhu, Y., Ding, W., Yang, S. (2022). Antioxidant Effects of Resveratrol in Intervertebral Disk. Journal of Investigative Surgery, 35(5), 1135-1144. [More Information]
Li, W., Lai, K., Chopra, N., Zheng, Z., Das, A., Diwan, A. (2022). Gut-disc axis: A cause of intervertebral disc degeneration and low back pain? European Spine Journal, 31(4), 917-925. [More Information]
Tu, J., Li, W., Yang, S., Yang, P., Yan, Q., Wang, S., Lai, K., Bai, X., Wu, C., Ding, W., et al (2022). Single-Cell Transcriptome Profiling Reveals Multicellular Ecosystem of Nucleus Pulposus during Degeneration Progression. Advanced Science, 9(3), 2103631. [More Information]
Tavana, N., Ting, T., Lai, K., Kennerson, M., Thilakavathy, K. (2022). Whole exome sequencing identifies two novel variants in PHEX and DMP1 in Malaysian children with hypophosphatemic rickets. The Italian Journal of Pediatrics (Print), 48(1). [More Information]

show 1 more

2021

Gonzalez-Rajal, A., Marzec, K., McCloy, R., Nobis, M., Chin, V., Hastings, J., Lai, K., Kennerson, M., Hughes, W., Vaghjiani, V., Burgess, A., et al (2021). A non-genetic, cell cycle dependent mechanism of platinum resistance in lung adenocarcinoma. eLife, 10, 1-28. [More Information]

2020

Johnson, T., Schelch, K., Lai, K., Marzec, K., Kennerson, M., Grusch, M., Reid, G., Burgess, A. (2020). YB-1 knockdown inhibits the proliferation of mesothelioma cells through multiple mechanisms. Cancers, 12(8), 1-21. [More Information]

2019

Lai, K., Twine, N., O'Brien, A., Guo, Y., Bauer, D. (2019). Artificial Intelligence and Machine Learning in Bioinformatics. In S. Raganathan, M. Gribskov, K. Nakai. C. Schonbach (Eds.), Encyclopedia of Bioinformatics and Computational Biology, (pp. 272-286). United States of America: Elsevier. [More Information]
Abadir, E., Gasiorowski, R., Lai, K., Kupresanin, F., Romano, A., Silveira, P., Lo, T., Fromm, P., Kennerson, M., Iland, H., Ho, P., Hart, D., Clark, G., et al (2019). CD300f epitopes are specific targets for acute myeloid leukemia with monocytic differentiation. Molecular Oncology, 13(10), 2107-2120. [More Information]

2018

Jeffries, T., Rayu, S., Nielsen, U., Lai, K., Ijaz, A., Nazaries, L., Singh, B. (2018). Metagenomic Functional Potential Predicts Degradation Rates of a Model Organophosphorus Xenobiotic in Pesticide Contaminated Soils. Frontiers in Microbiology, 9(February), 147. [More Information]
Li, J., Lin, J., Pei, C., Lai, K., Jeffries, T., Tang, G. (2018). Variation of soil bacterial communities along a chronosequence of Eucalyptus plantation. PeerJ, 6, e5648. [More Information]

2017

Trivedi, P., Delgado-Baquerizo, M., Jeffries, T., Trivedi, C., Anderson, I., Lai, K., McNee, M., Flower, K., Singh, B., Minkey, D., et al (2017). Soil aggregation and associated microbial communities modify the impact of agricultural management on carbon content. Environmental Microbiology, 19(8), 3070-3086. [More Information]
Montenegro, J., Golicz, A., Bayer, P., Hurgobin, B., Lee, H., Chan, C., Visendi, P., Lai, K., Dolezel, J., Batley, J., et al (2017). The pangenome of hexaploid bread wheat. Plant Journal, 90(5), 1007-1013. [More Information]

2016

Lai, K. (2016). WheatGenome. info: A Resource for Wheat Genomics Resource. In David Edwards (Eds.), Plan Bioinformatics - Methods and Protocols (Second Edition), (pp. 203-213). New york: Humana Press. [More Information]

2015

Lai, K., Lorenc, M., Lee, H., Berkman, P., Bayer, P., Visendi, P., Ruperao, P., Fitzgerald, T., Zander, M., Chan, C., et al (2015). Identification and characterization of more than 4 million intervarietal SNPs across the group 7 chromosomes of bread wheat. Plant Biotechnology Journal, 13(1), 97-104. [More Information]
Lai, K., Lorenc, M., Edwards, D. (2015). Molecular Marker Databases. In Jacqueline Batley (Eds.), Plant Genotyping: Methods and Protocols, (pp. 49-62). New York: Springer. [More Information]

2013

Zander, M., Patel, D., Van de Wouw, A., Lai, K., Lorenc, M., Campbell, E., Hayward, A., Edwards, D., Raman, H., Batley, J. (2013). Identifying genetic diversity of avirulence genes in Leptosphaeria maculans using whole genome sequencing. Functional and Integrative Genomics, 13(3), 295-308. [More Information]

2012

Lee, H., Lai, K., Lorenc, M., Imelfort, M., Duran, C., Edwards, D. (2012). Bioinformatics tools and databases for analysis of next-generation sequence data. Briefings in Functional Genomics, 11(1), 12-24. [More Information]
Lorenc, M., Hayashi, S., Stiller, J., Lee, H., Manoli, S., Ruperao, P., Visendi, P., Berkman, P., Lai, K., Batley, J., et al (2012). Discovery of Single Nucleotide Polymorphisms in Complex Genomes Using SGSautoSNP. Biology, 1(2), 370-382. [More Information]
Berkman, P., Lai, K., Lorenc, M., Edwards, D. (2012). Next-generation sequencing applications for wheat crop improvement. American Journal of Botany, 99(2), 365-371. [More Information]
Berkman, P., Skarshewski, A., Manoli, S., Lorenc, M., Stiller, J., Smits, L., Lai, K., Campbell, E., Kubalakova, M., Simkova, H., et al (2012). Sequencing wheat chromosome arm 7BS delimits the 7BS/4AL translocation and reveals homoeologous gene conservation. Theoretical and Applied Genetics, 124(3), 423-432. [More Information]
Lai, K., Berkman, P., Duran, C., Lorenc, M., Stiller, J., Manoli, S., Hayden, M., Forrest, K., Fleury, D., Baumann, U., et al (2012). Single nucleotide polymorphism discovery from wheat next-generation sequence data. Plant Biotechnology Journal, 10(6), 743-749. [More Information]
Lai, K., Berkman, P., Lorenc, M., Duran, C., Smits, L., Manoli, S., Stiller, J., Edwards, D. (2012). WheatGenomeinfo: an integrated database and portal for wheat genome information. Plant and Cell Physiology, 53(2), 1-7. [More Information]

show 3 more

2011

Berkman, P., Skarshewski, A., Lorenc, M., Lai, K., Duran, C., Ling, E., Stiller, J., Smits, L., Imelfort, M., Manoli, S., et al (2011). Sequencing and assembly of low copy and genic regions of isolated Triticum aestivum chromosome arm 7DS. Plant Biotechnology Journal, 9(7), 768-775. [More Information]

Page not found

Dr Kaitao Lai

Publications

By Type

By Year