People_

Dr Kavitha Kothur

NHMRC Senior Research Fellow
Children's Hospital at Westmead
Faculty of Medicine and Health

Phone

98452657

Email

kavitha.kothur@sydney.edu.au

Details

Member of the Brain and Mind Centre

Research interests

Dr Kothur is a paediatric neurologist. She completed a PhD in the development of cerebrospinal fluid biomarkers in paediatric neurological disorders. Her research is focussed on genetic testing in refractory epilepsy, functional genomics, improving seizure, social and cognitive outcomes following epilepsy surgery and understanding role of inflammation in epilepsy. She aims to translate reteach into the practice of personalised medicine of epilepsy.

She has key collaborations with A/Prof Bruce Bennett (Molecular genetics laboratory), Sarah McIntyre (CPAlliance), Dr Deepak Gill (Epilepsy), Prof Sunny Lah (Psychosocial outcome), Prof Patrick Kwan (Genomics), and Prof Mary Collins (GABAR functional genomics).

Current projects

Epilepsy in Cerebral Palsy: defining prevalence and risk factors, quality of life, and subgroups of genetic and surgically remediable epilepsy

Clinical utility and cost-effectiveness of genome sequencing for refractory epilepsy in children and adults: a multicentre randomised controlled trial

Associations

Kids Neuroscience Centre, The Sydeny Children's Hospital Network

Keywords

Child health, Epilepsy, Genetics, Neurosciences, Biological markers

Clinical speciality

Neurology

Publications

By Type

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Journals

Ng, V., Hart, F., Kothur, K., Buckley, M., Harb, C., Gill, D. (2024). Epilepsy with eyelid myoclonia with atonic seizures and generalized paroxysmal fast activity: A novel electroclinical phenotype associated with SETD1B pathogenic variant. Epileptic Disorders, 26(2), 250-253. [More Information]
Musto, E., Delaby, D., Ceulemans, B., Weckhuysen, S., Sparber, P., Bouman, A., Ardern-Holmes, S., Troedson, C., Battaglia, D., Goel, H., Liao, V., Collins, M., Ahring, J., Kothur, K., Bennetts, B., et al (2024). GABRA1-Related Disorders: From Genetic to Functional Pathways. Annals of Neurology, 95(1), 27-41. [More Information]
Dale, R., Thomas, T., Patel, S., Han, V., Kothur, K., Troedson, C., Gupta, S., Gill, D., Subramanian, G., Andrews, P., Menezes, M., Ardern-Holmes, S., Mohammad, S., Bandodkar, S., Yan, J., et al (2023). CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. Annals of Clinical and Translational Neurology, 10(8), 1417-1432. [More Information]
Yan, J., Kothur, K., Mohammad, S., Chung, J., Patel, S., Jones, H., Keating, B., Han, V., Webster, R., Ardern-Holmes, S., Antony, J., Menezes, M., Tantsis, E., Gill, D., Gupta, S., Troedson, C., Bandodkar, S., Dale, R., et al (2023). CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. EBioMedicine, 91. [More Information]
Chan, D., Rudinger-Thirion, J., Frugier, M., Riley, L., Ho, G., Kothur, K., Mohammad, S. (2022). A case of QARS1 associated epileptic encephalopathy and review of epilepsy in aminoacyl-tRNA synthetase disorders. Brain and Development, 44(2), 142-147. [More Information]
Jones, H., Stoll, M., Ho, G., O'Neill, D., Han, V., Paget, S., Stewart, K., Lewis, J., Kothur, K., Troedson, C., Dale, R., Mohammad, S., et al (2022). Autosomal dominant ADAR c.3019G>A (p.(G1007R)) variant is an important mimic of hereditary spastic paraplegia and cerebral palsy. Brain and Development, 44(2), 153-160. [More Information]
Yan, J., Kothur, K., Innes, E., Han, V., Jones, H., Patel, S., Tsang, E., Webster, R., Gupta, S., Troedson, C., Menezes, M., Antony, J., Ardern-Holmes, S., Tantsis, E., Mohammad, S., Gill, D., Bandodkar, S., Dale, R., et al (2022). Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. EBioMedicine, 84. [More Information]
Ka, A., Taher, A., D'Souza, S., Barnes, E., Gupta, S., Troedson, C., Wade, F., Teo, O., Dale, R., Wong, C., Kothur, K., Gill, D., et al (2022). Predictors of longitudinal seizure outcomes after epilepsy surgery in childhood. Epilepsy & Behavior Reports, 19. [More Information]
Nevin, S., Wakefield, C., Barlow-Stewart, K., McGill, B., Bye, A., Palmer, E., Dale, R., Gill, D., Kothur, K., Boggs, K., et al (2022). Psychosocial impact of genetic testing on parents of children with developmental and epileptic encephalopathy. Developmental Medicine and Child Neurology, 64(1), 95-104. [More Information]
Han, V., Kozlowska, K., Kothur, K., Lorentzos, M., Wong, W., Mohammad, S., Savage, B., Chudleigh, C., Dale, R. (2022). Rapid onset functional tic-like behaviours in children and adolescents during COVID-19: Clinical features, assessment and biopsychosocial treatment approach. Journal of Paediatrics and Child Health, 58(7), 1181-1187. [More Information]
Wienholt, L., Kane, A., Adelstein, S., Richardson, A., Kothur, K., Brilot-Turville, F., Dale, R. (2021). Cerebrospinal fluid free light chain quantitation is a specific biomarker for inflammatory neurological disorders in a paediatric patient cohort. Pathology, 53(6), 753-758. [More Information]
Pham, D., Pitman, M., Kumar, R., Jolly, L., Schulz, R., Gardner, A., de Nys, R., Heron, S., Corbett, M., Kothur, K., Gill, D., et al (2021). Integrated in silico and experimental assessment of disease relevance of PCDH19 missense variants. Human Mutation, 42(8), 1030-1041. [More Information]
Jones, H., Han, V., Patel, S., Gloss, B., Soler, N., Ho, A., Sharma, S., Kothur, K., Nosadini, M., Wienholt, L., Barnes, E., Lim, J., Alshammery, S., Nielsen, T., Hofer, M., Nassar, N., Gold, W., Brilot-Turville, F., Mohammad, S., Dale, R., et al (2021). Maternal autoimmunity and inflammation are associated with childhood tics and obsessive-compulsive disorder: Transcriptomic data show common enriched innate immune pathways. Brain, Behavior, and Immunity, 94, 308-317. [More Information]
Azevedo, S., Kothur, K., Gupta, S., Webster, R., Dale, R., Wade, F., Gill, D., Lah, S. (2020). Deficits in all aspects of social competence identified in children who have undergone epilepsy surgery. Epilepsy and Behavior, 112, 107388. [More Information]
Waak, M., Malone, S., Sinclair, K., Phillips, G., Bandodkar, S., Wienholt, L., Robertson, T., Whitehead, B., Trnka, P., Kothur, K., Dale, R. (2019). Acute Hemorrhagic Leukoencephalopathy: Pathological Features and Cerebrospinal Fluid Cytokine Profiles. Pediatric Neurology, 100, 92-96. [More Information]
Kothur, K., Troedson, C., Webster, R., Bandodkar, S., Chu, S., Wienholt, L., Pope, A., Mackay, M., Dale, R. (2019). Elevation of cerebrospinal fluid cytokine/chemokines involved in innate, T cell, and granulocyte inflammation in pediatric focal cerebral arteriopathy. International Journal of Stroke, 14(2), 154-158. [More Information]
Kothur, K., Bandodkar, S., Wienholt, L., Chu, S., Pope, A., Gill, D., Dale, R. (2019). Etiology is the key determinant of neuroinflammation in epilepsy: Elevation of cerebrospinal fluid cytokines and chemokines in febrile infection-related epilepsy syndrome and febrile status epilepticus. Epilepsia, 60(8), 1678-1688. [More Information]
Jones, H., Ho, A., Sharma, S., Mohammad, S., Kothur, K., Patel, S., Brilot-Turville, F., Guastella, A., Dale, R., Hofer, M. (2019). Maternal thyroid autoimmunity associated with acute-onset neuropsychiatric disorders and global regression in offspring. Developmental Medicine and Child Neurology, 61(8), 984-988. [More Information]
Kothur, K., Bandodkar, S., Chu, S., Wienholt, L., Johnson, A., Barclay, P., Brogan, P., Rice, G., Crow, Y., Dale, R. (2018). An open-label trial of JAK 1/2 blockade in progressive IFIH1-associated neuroinflammation. Neurology, 90(6), 289-291. [More Information]
Kothur, K., Holman, K., Farnsworth, E., Ho, G., Lorentzos, M., Troedson, C., Gupta, S., Webster, R., Procopis, P., Menezes, M., Ardern-Holmes, S., Dale, R., Gill, D., Bennetts, B., et al (2018). Diagnostic yield of targeted massively parallel sequencing in children with epileptic encephalopathy. Seizure: European Journal of Epilepsy, 59, 132-140. [More Information]
Kothur, K., Gill, D., Wong, M., Mohammad, S., Bandodkar, S., Arbunckle, S., Wienholt, L., Dale, R. (2017). Cerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae. Developmental Medicine and Child Neurology, 59(8), 806-814. [More Information]
Nosadini, M., Mohammad, S., Corazza, F., Ruga, E., Kothur, K., Perilongo, G., Frigo, A., Toldo, I., Dale, R., Sartori, S. (2017). Herpes simplex virus-induced anti-N-methyl-D-aspartate receptor encephalitis: a systematic literature review with analysis of 43 cases. Developmental Medicine and Child Neurology, 59(8), 796-805. [More Information]
Kothur, K., Wienholt, L., Tantsis, E., Earl, J., Bandodkar, S., Prelog, K., Tea, F., Ramanathan, S., Brilot-Turville, F., Dale, R. (2016). B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination. PloS One, 11(2), 1-16. [More Information]
Kothur, K., Wienholt, L., Brilot, F., Dale, R. (2016). CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review. Cytokine, 77, 227-237. [More Information]
Kothur, K., Wienholt, L., Mohammad, S., Tantsis, E., Pillai, S., Britton, P., Jones, C., Angiti, R., Barnes, E., Schlub, T., Brilot-Turville, F., Dale, R., et al (2016). Utility of CSF Cytokine/Chemokines as Markers of Active Intrathecal Inflammation: Comparison of Demyelinating, Anti-NMDAR and Enteroviral Encephalitis. PloS One, 11(8), 1-19. [More Information]
Chudleigh, C., Kozlowska, K., Kothur, K., Davies, F., Baxter, H., Landini, A., Hazell, P., Baslet, G. (2013). Managing Non-epileptic Seizures and Psychogenic Dystonia in an Adolescent Girl with Preterm Brain Injury. Harvard Review of Psychiatry, 21(3), 163-174. [More Information]
Kothur, K., Kaul, S., Rammurthi, S., Srinivasarao Bandar, V., Suryaprabha, S., Rukmini Mrudula, K. (2012). Use of thrombolytic therapy in cerebral venous sinus thrombosis with ulcerative colitis. Annals of Indian Academy of Neurology, 15(1), 35-38. [More Information]

show 24 more

By Year

Expand all

2024

Ng, V., Hart, F., Kothur, K., Buckley, M., Harb, C., Gill, D. (2024). Epilepsy with eyelid myoclonia with atonic seizures and generalized paroxysmal fast activity: A novel electroclinical phenotype associated with SETD1B pathogenic variant. Epileptic Disorders, 26(2), 250-253. [More Information]
Musto, E., Delaby, D., Ceulemans, B., Weckhuysen, S., Sparber, P., Bouman, A., Ardern-Holmes, S., Troedson, C., Battaglia, D., Goel, H., Liao, V., Collins, M., Ahring, J., Kothur, K., Bennetts, B., et al (2024). GABRA1-Related Disorders: From Genetic to Functional Pathways. Annals of Neurology, 95(1), 27-41. [More Information]

2023

Dale, R., Thomas, T., Patel, S., Han, V., Kothur, K., Troedson, C., Gupta, S., Gill, D., Subramanian, G., Andrews, P., Menezes, M., Ardern-Holmes, S., Mohammad, S., Bandodkar, S., Yan, J., et al (2023). CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. Annals of Clinical and Translational Neurology, 10(8), 1417-1432. [More Information]
Yan, J., Kothur, K., Mohammad, S., Chung, J., Patel, S., Jones, H., Keating, B., Han, V., Webster, R., Ardern-Holmes, S., Antony, J., Menezes, M., Tantsis, E., Gill, D., Gupta, S., Troedson, C., Bandodkar, S., Dale, R., et al (2023). CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. EBioMedicine, 91. [More Information]

2022

Chan, D., Rudinger-Thirion, J., Frugier, M., Riley, L., Ho, G., Kothur, K., Mohammad, S. (2022). A case of QARS1 associated epileptic encephalopathy and review of epilepsy in aminoacyl-tRNA synthetase disorders. Brain and Development, 44(2), 142-147. [More Information]
Jones, H., Stoll, M., Ho, G., O'Neill, D., Han, V., Paget, S., Stewart, K., Lewis, J., Kothur, K., Troedson, C., Dale, R., Mohammad, S., et al (2022). Autosomal dominant ADAR c.3019G>A (p.(G1007R)) variant is an important mimic of hereditary spastic paraplegia and cerebral palsy. Brain and Development, 44(2), 153-160. [More Information]
Yan, J., Kothur, K., Innes, E., Han, V., Jones, H., Patel, S., Tsang, E., Webster, R., Gupta, S., Troedson, C., Menezes, M., Antony, J., Ardern-Holmes, S., Tantsis, E., Mohammad, S., Gill, D., Bandodkar, S., Dale, R., et al (2022). Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. EBioMedicine, 84. [More Information]
Ka, A., Taher, A., D'Souza, S., Barnes, E., Gupta, S., Troedson, C., Wade, F., Teo, O., Dale, R., Wong, C., Kothur, K., Gill, D., et al (2022). Predictors of longitudinal seizure outcomes after epilepsy surgery in childhood. Epilepsy & Behavior Reports, 19. [More Information]
Nevin, S., Wakefield, C., Barlow-Stewart, K., McGill, B., Bye, A., Palmer, E., Dale, R., Gill, D., Kothur, K., Boggs, K., et al (2022). Psychosocial impact of genetic testing on parents of children with developmental and epileptic encephalopathy. Developmental Medicine and Child Neurology, 64(1), 95-104. [More Information]
Han, V., Kozlowska, K., Kothur, K., Lorentzos, M., Wong, W., Mohammad, S., Savage, B., Chudleigh, C., Dale, R. (2022). Rapid onset functional tic-like behaviours in children and adolescents during COVID-19: Clinical features, assessment and biopsychosocial treatment approach. Journal of Paediatrics and Child Health, 58(7), 1181-1187. [More Information]

show 3 more

2021

Wienholt, L., Kane, A., Adelstein, S., Richardson, A., Kothur, K., Brilot-Turville, F., Dale, R. (2021). Cerebrospinal fluid free light chain quantitation is a specific biomarker for inflammatory neurological disorders in a paediatric patient cohort. Pathology, 53(6), 753-758. [More Information]
Pham, D., Pitman, M., Kumar, R., Jolly, L., Schulz, R., Gardner, A., de Nys, R., Heron, S., Corbett, M., Kothur, K., Gill, D., et al (2021). Integrated in silico and experimental assessment of disease relevance of PCDH19 missense variants. Human Mutation, 42(8), 1030-1041. [More Information]
Jones, H., Han, V., Patel, S., Gloss, B., Soler, N., Ho, A., Sharma, S., Kothur, K., Nosadini, M., Wienholt, L., Barnes, E., Lim, J., Alshammery, S., Nielsen, T., Hofer, M., Nassar, N., Gold, W., Brilot-Turville, F., Mohammad, S., Dale, R., et al (2021). Maternal autoimmunity and inflammation are associated with childhood tics and obsessive-compulsive disorder: Transcriptomic data show common enriched innate immune pathways. Brain, Behavior, and Immunity, 94, 308-317. [More Information]

2020

Azevedo, S., Kothur, K., Gupta, S., Webster, R., Dale, R., Wade, F., Gill, D., Lah, S. (2020). Deficits in all aspects of social competence identified in children who have undergone epilepsy surgery. Epilepsy and Behavior, 112, 107388. [More Information]

2019

Waak, M., Malone, S., Sinclair, K., Phillips, G., Bandodkar, S., Wienholt, L., Robertson, T., Whitehead, B., Trnka, P., Kothur, K., Dale, R. (2019). Acute Hemorrhagic Leukoencephalopathy: Pathological Features and Cerebrospinal Fluid Cytokine Profiles. Pediatric Neurology, 100, 92-96. [More Information]
Kothur, K., Troedson, C., Webster, R., Bandodkar, S., Chu, S., Wienholt, L., Pope, A., Mackay, M., Dale, R. (2019). Elevation of cerebrospinal fluid cytokine/chemokines involved in innate, T cell, and granulocyte inflammation in pediatric focal cerebral arteriopathy. International Journal of Stroke, 14(2), 154-158. [More Information]
Kothur, K., Bandodkar, S., Wienholt, L., Chu, S., Pope, A., Gill, D., Dale, R. (2019). Etiology is the key determinant of neuroinflammation in epilepsy: Elevation of cerebrospinal fluid cytokines and chemokines in febrile infection-related epilepsy syndrome and febrile status epilepticus. Epilepsia, 60(8), 1678-1688. [More Information]
Jones, H., Ho, A., Sharma, S., Mohammad, S., Kothur, K., Patel, S., Brilot-Turville, F., Guastella, A., Dale, R., Hofer, M. (2019). Maternal thyroid autoimmunity associated with acute-onset neuropsychiatric disorders and global regression in offspring. Developmental Medicine and Child Neurology, 61(8), 984-988. [More Information]

show 1 more

2018

Kothur, K., Bandodkar, S., Chu, S., Wienholt, L., Johnson, A., Barclay, P., Brogan, P., Rice, G., Crow, Y., Dale, R. (2018). An open-label trial of JAK 1/2 blockade in progressive IFIH1-associated neuroinflammation. Neurology, 90(6), 289-291. [More Information]
Kothur, K., Holman, K., Farnsworth, E., Ho, G., Lorentzos, M., Troedson, C., Gupta, S., Webster, R., Procopis, P., Menezes, M., Ardern-Holmes, S., Dale, R., Gill, D., Bennetts, B., et al (2018). Diagnostic yield of targeted massively parallel sequencing in children with epileptic encephalopathy. Seizure: European Journal of Epilepsy, 59, 132-140. [More Information]

2017

Kothur, K., Gill, D., Wong, M., Mohammad, S., Bandodkar, S., Arbunckle, S., Wienholt, L., Dale, R. (2017). Cerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae. Developmental Medicine and Child Neurology, 59(8), 806-814. [More Information]
Nosadini, M., Mohammad, S., Corazza, F., Ruga, E., Kothur, K., Perilongo, G., Frigo, A., Toldo, I., Dale, R., Sartori, S. (2017). Herpes simplex virus-induced anti-N-methyl-D-aspartate receptor encephalitis: a systematic literature review with analysis of 43 cases. Developmental Medicine and Child Neurology, 59(8), 796-805. [More Information]

2016

Kothur, K., Wienholt, L., Tantsis, E., Earl, J., Bandodkar, S., Prelog, K., Tea, F., Ramanathan, S., Brilot-Turville, F., Dale, R. (2016). B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination. PloS One, 11(2), 1-16. [More Information]
Kothur, K., Wienholt, L., Brilot, F., Dale, R. (2016). CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review. Cytokine, 77, 227-237. [More Information]
Kothur, K., Wienholt, L., Mohammad, S., Tantsis, E., Pillai, S., Britton, P., Jones, C., Angiti, R., Barnes, E., Schlub, T., Brilot-Turville, F., Dale, R., et al (2016). Utility of CSF Cytokine/Chemokines as Markers of Active Intrathecal Inflammation: Comparison of Demyelinating, Anti-NMDAR and Enteroviral Encephalitis. PloS One, 11(8), 1-19. [More Information]

2013

Chudleigh, C., Kozlowska, K., Kothur, K., Davies, F., Baxter, H., Landini, A., Hazell, P., Baslet, G. (2013). Managing Non-epileptic Seizures and Psychogenic Dystonia in an Adolescent Girl with Preterm Brain Injury. Harvard Review of Psychiatry, 21(3), 163-174. [More Information]

2012

Kothur, K., Kaul, S., Rammurthi, S., Srinivasarao Bandar, V., Suryaprabha, S., Rukmini Mrudula, K. (2012). Use of thrombolytic therapy in cerebral venous sinus thrombosis with ulcerative colitis. Annals of Indian Academy of Neurology, 15(1), 35-38. [More Information]

Selected Grants

2022

Biomarker discovery informs precision medicine in childhood epilepsy, Kothur K, National Health and Medical Research Council (NHMRC)/Investigator Grant

Faculty of Medicine and Health

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