People_

Dr Kerrie Sandgren

Research Focused Academic
Faculty of Medicine and Health, Westmead Clinical School, University of Sydney
The Westmead Institute for Medical Research

Phone

+61 2 86273919

Email

kerrie.sandgren@sydney.edu.au

Websites

Honours in Medical Sciences at Westmead

Member of: Sydney Infectious Diseases Institute (Sydney ID)

Biographical details

Kerrie is an experienced immunologist who spent 4 years at the Karolinska Institute in Sweden and at the Vaccine Research Center, National Institutes of Health in the USA studying what dendritic cells do when they encounter viral and vaccine components. She now continues her work at the Centre for Virus Research at the Westmead Institute with a small group, focusing on the innate immune response to vaccine components in human lymph nodes.

Research interests

Kerrie is interested in how the immune activating component of some vaccines, called adjuvants, prompt the immune system to behave in such specific ways and how we can harness this information to improve vaccines for older people, giving them better protection against diseases such as influenza and COVID-19.

She is also interested in how our immune system functions in the skin - from the perspective of vaccination and also viral infection. Of particular interest is the interplay between herpes simplex virus infection and the early innate immune response to the virus, that occurs in the skin.

Themes

Infection and Immunological Conditions

Keywords

HIV/AIDS, Vaccines and vaccinology, Dendritic cells, Innate Immunity, Adjuvants

Approaches

Immunology

Current research students

Project title	Research student
Investigating neuroimmune interactions in chronic neuropathic pain conditions using high-parameter cytometry technologies.	Jackson KARRASCH
DECIPHER MECHANISMS OF ACTION OF ADJUVANT SYSTEM AS01 AND RELATED ADJUVANTS IN HUMAN LYMPH NODES FROM OLD AND YOUNG DONORS	Sifan ZHANG

Publications

By Type

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Journals

Warner Van Dijk, F., Tong, O., Oneil, T., Bertram, K., Hu, K., Baharlou, H., Vine, E., Jenns, K., Gosselink, M., Toh, J., Harman, A., Nasr, N., et al (2024). Characterising plasmacytoid and myeloid AXL+ SIGLEC6+ dendritic cell functions and their interactions with HIV. PLoS Pathogens, 20(6), e1012351. [More Information]
Rana, H., Truong (Osborne), N., Johnon, B., Baharlou, H., Herbert, J., Kandasamy, S., Goddard, R., Cohen, R., Wines, M., Nasr, N., Harman, A., Bertram, K., Sandgren, K., Cunningham, A. (2024). Herpes simplex virus spreads rapidly in human foreskin, partly driven by chemokine-induced redistribution of Nectin-1 on keratinocytes. PLoS Pathogens, 20(6 June), e1012267. [More Information]
Cunningham, A., Sandgren, K., Truong (Osborne), N. (2023). Advances in understanding the mechanism of action of adult vaccines. Journal of Clinical Investigation, 133(23). [More Information]
Duette, G., Lee, E., Gomes, G., Tungatt, K., Doyle, C., Stylianou, V., Lee, A., Maddocks, S., Taylor, J., Khanna, R., Sandgren, K., Cunningham, A., Palmer, S., et al (2023). Highly Networked SARS-CoV-2 Peptides Elicit T Cell Responses with Enhanced Specificity. ImmunoHorizons, 7(6), 508-527. [More Information]
Baharlou, H., Canete, N., Vine, E., Hu, K., Yuan, D., Sandgren, K., Bertram, K., Nasr, N., Rhodes, J., Gosselink, M., Patrick, E., Byrne, S., Cunningham, A., Harman, A., et al (2022). An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission. Cell Reports, 40(12), 111385-1-111385-27. [More Information]
Shen, Y., Freeman, J., Holland, J., Solterbeck, A., Naidu, K., Soosapilla, A., Downe, P., Tang, C., Kerridge, I., Wallman, L., Martins Costa Gomes, G., Sandgren, K., Cunningham, A., et al (2022). COVID-19 vaccine failure in chronic lymphocytic leukaemia and monoclonal B-lymphocytosis; humoural and cellular immunity. British Journal of Haematology, 197(1), 41-51. [More Information]
Shen, Y., Freeman, J., Holland, J., Naidu, K., Solterbeck, A., Van Bilsen, N., Downe, P., Kerridge, I., Wallman, L., Akerman, A., Martins Costa Gomes, G., Doyle, C., Sandgren, K., Cunningham, A., et al (2022). Multiple COVID-19 vaccine doses in CLL and MBL improve immune responses with progressive and high seroconversion. Blood, 140(25), 2709-2721. [More Information]
Arnous, R., Arshad, S., Sandgren, K., Cunningham, A., Carnt, N., White, A. (2022). Tissue resident memory T cells inhabit the deep human conjunctiva. Scientific Reports, 12(1), 6077. [More Information]
Baharlou, H., Canete, N., Bertram, K., Sandgren, K., Cunningham, A., Harman, A., Patrick, E. (2021). AFid: a tool for automated identification and exclusion of autofluorescent objects from microscopy images. Bioinformatics, 37(4), 559-567. [More Information]
Bertram, K., Truong (Osborne), N., Smith, J., Kim, M., Sandgren, K., Feng, K., Herbert, J., Rana, H., Danastas, K., Miranda Saksena, M., Rhodes, J., Cohen, R., Harman, A., Cunningham, A., et al (2021). Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways. PLoS Pathogens, 17(4), e1009536. [More Information]
Lee, E., Sandgren, K., Duette, G., Stylianou, V., Khanna, R., Eden, J., Blyth, E., Gottlieb, D., Cunningham, A., Palmera, S. (2021). Identification of SARS-CoV-2 nucleocapsid and spike T-cell epitopes for assessing T-cell immunity. Journal of Virology, 95(6), 2002. [More Information]
Sandgren, K., Truong, N., Smith, J., Bertram, K., Cunningham, A. (2020). Vaccines for Herpes Simplex: Recent Progress Driven by Viral and Adjuvant Immunology. Methods in Molecular Biology, 2060, 31-56. [More Information]
Truong (Osborne), N., Smith, J., Sandgren, K., Cunningham, A. (2019). Mechanisms of immune control of mucosal HSV infection: A guide to rational vaccine design. Frontiers in Immunology, 10, 1-17. [More Information]
Botting, R., Bertram, K., Baharlou, H., Sandgren, K., Fletcher, J., Rhodes, J., Rana, H., Plasto, T., Wang, X., Lim, J., Cunningham, A., Harman, A., et al (2017). Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. Journal of Leukocyte Biology, 101(6), 1393-1403. [More Information]
Liang, F., Lindgren, G., Sandgren, K., Thompson, E., Francica, J., Seubert, A., Gregorio, E., Barnett, S., O'hagan, D., Sullivan, N., et al (2017). Vaccine priming is restricted to draining lymph nodes & controlled by adjuvant-mediated antigen uptake. Science Translational Medicine, 9(393). [More Information]
Sandgren, K., Bertram, K., Cunningham, A. (2016). Understanding natural herpes simplex virus immunity to inform next-generation vaccine design. Clinical & Translational Immunology, 5, 1-8. [More Information]
Salvador, A., Sandgren, K., Liang, F., Thompson, E., Koup, R., Pedraz, J., Hernandez, R., Loré, K., Igartua, M. (2015). Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses. International Journal of Pharmaceutics, 496(2), 371-381. [More Information]
Thompson, E., Liang, F., Lindgren, G., Sandgren, K., Quinn, K., Darrah, P., Koup, R., Seder, R., Kedl, R., Loré, K. (2015). Human anti-CD40 antibody and poly IC:LC adjuvant combination induces potent T cell responses in the lung of nonhuman primates. Journal of Immunology, 195(3), 1015-1024. [More Information]
Baharom, F., Thomas, S., Bieder, A., Hellmér, M., Volz, J., Sandgren, K., McInerney, G., Karlsson Hedestam, G., Mellman, I., Smed-Sörensen, A. (2015). Protection of Human myeloid dendritic cell subsets against influenza a virus infection is differentially regulated upon TLR stimulation. Journal of Immunology, 194(9), 4422-4430. [More Information]
Kim, M., Truong (Osborne), N., James, V., Bosnjak, L., Sandgren, K., Harman, A., Nasr, N., Bertram, K., Olbourne, N., Sawleshwarkar, S., Cunningham, A., et al (2015). Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. PLoS Pathogens, 11(4), 1-19. [More Information]
Liang, F., Bond, E., Sandgren, K., Smed-Sörensen, A., Rangaka, M., Lange, C., Koup, R., McComsey, G., Lederman, M., Wilkinson, R., et al (2013). Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration. AIDS, 27(7), 1071-1080. [More Information]
Sandgren, K., Smed-Sörensen, A., Forsell, M., Soldemo, M., Adams, W., Liang, F., Perbeck, L., Koup, R., Wyatt, R., Karlsson Hedestam, G., et al (2013). Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation. Journal of Immunology, 191(1), 60-69. [More Information]
Harman, A., Bye, C., Nasr, N., Sandgren, K., Kim, M., Mercier, S., Botting, R., Lewin, S., Cunningham, A., Cameron, P. (2013). Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells. Journal of Immunology, 190(1), 66-79. [More Information]
Mercier, S., Donaghy, H., Botting, R., Turville, S., Harman, A., Nasr, N., Ji, H., Kusebauch, U., Mendoza, L., Shteynberg, D., Cunningham, A., et al (2013). The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes. PLoS Pathogens, 9(10), 1-18. [More Information]
Harman, A., Kim, M., Nasr, N., Sandgren, K., Cameron, P. (2013). Tissue dendritic cells as portals for HIV entry. Reviews in Medical Virology, 23(5), 319-333. [More Information]

show 22 more

By Year

Expand all

2024

Warner Van Dijk, F., Tong, O., Oneil, T., Bertram, K., Hu, K., Baharlou, H., Vine, E., Jenns, K., Gosselink, M., Toh, J., Harman, A., Nasr, N., et al (2024). Characterising plasmacytoid and myeloid AXL+ SIGLEC6+ dendritic cell functions and their interactions with HIV. PLoS Pathogens, 20(6), e1012351. [More Information]
Rana, H., Truong (Osborne), N., Johnon, B., Baharlou, H., Herbert, J., Kandasamy, S., Goddard, R., Cohen, R., Wines, M., Nasr, N., Harman, A., Bertram, K., Sandgren, K., Cunningham, A. (2024). Herpes simplex virus spreads rapidly in human foreskin, partly driven by chemokine-induced redistribution of Nectin-1 on keratinocytes. PLoS Pathogens, 20(6 June), e1012267. [More Information]

2023

Cunningham, A., Sandgren, K., Truong (Osborne), N. (2023). Advances in understanding the mechanism of action of adult vaccines. Journal of Clinical Investigation, 133(23). [More Information]
Duette, G., Lee, E., Gomes, G., Tungatt, K., Doyle, C., Stylianou, V., Lee, A., Maddocks, S., Taylor, J., Khanna, R., Sandgren, K., Cunningham, A., Palmer, S., et al (2023). Highly Networked SARS-CoV-2 Peptides Elicit T Cell Responses with Enhanced Specificity. ImmunoHorizons, 7(6), 508-527. [More Information]

2022

Baharlou, H., Canete, N., Vine, E., Hu, K., Yuan, D., Sandgren, K., Bertram, K., Nasr, N., Rhodes, J., Gosselink, M., Patrick, E., Byrne, S., Cunningham, A., Harman, A., et al (2022). An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission. Cell Reports, 40(12), 111385-1-111385-27. [More Information]
Shen, Y., Freeman, J., Holland, J., Solterbeck, A., Naidu, K., Soosapilla, A., Downe, P., Tang, C., Kerridge, I., Wallman, L., Martins Costa Gomes, G., Sandgren, K., Cunningham, A., et al (2022). COVID-19 vaccine failure in chronic lymphocytic leukaemia and monoclonal B-lymphocytosis; humoural and cellular immunity. British Journal of Haematology, 197(1), 41-51. [More Information]
Shen, Y., Freeman, J., Holland, J., Naidu, K., Solterbeck, A., Van Bilsen, N., Downe, P., Kerridge, I., Wallman, L., Akerman, A., Martins Costa Gomes, G., Doyle, C., Sandgren, K., Cunningham, A., et al (2022). Multiple COVID-19 vaccine doses in CLL and MBL improve immune responses with progressive and high seroconversion. Blood, 140(25), 2709-2721. [More Information]
Arnous, R., Arshad, S., Sandgren, K., Cunningham, A., Carnt, N., White, A. (2022). Tissue resident memory T cells inhabit the deep human conjunctiva. Scientific Reports, 12(1), 6077. [More Information]

show 1 more

2021

Baharlou, H., Canete, N., Bertram, K., Sandgren, K., Cunningham, A., Harman, A., Patrick, E. (2021). AFid: a tool for automated identification and exclusion of autofluorescent objects from microscopy images. Bioinformatics, 37(4), 559-567. [More Information]
Bertram, K., Truong (Osborne), N., Smith, J., Kim, M., Sandgren, K., Feng, K., Herbert, J., Rana, H., Danastas, K., Miranda Saksena, M., Rhodes, J., Cohen, R., Harman, A., Cunningham, A., et al (2021). Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways. PLoS Pathogens, 17(4), e1009536. [More Information]
Lee, E., Sandgren, K., Duette, G., Stylianou, V., Khanna, R., Eden, J., Blyth, E., Gottlieb, D., Cunningham, A., Palmera, S. (2021). Identification of SARS-CoV-2 nucleocapsid and spike T-cell epitopes for assessing T-cell immunity. Journal of Virology, 95(6), 2002. [More Information]

2020

Sandgren, K., Truong, N., Smith, J., Bertram, K., Cunningham, A. (2020). Vaccines for Herpes Simplex: Recent Progress Driven by Viral and Adjuvant Immunology. Methods in Molecular Biology, 2060, 31-56. [More Information]

2019

Truong (Osborne), N., Smith, J., Sandgren, K., Cunningham, A. (2019). Mechanisms of immune control of mucosal HSV infection: A guide to rational vaccine design. Frontiers in Immunology, 10, 1-17. [More Information]

2017

Botting, R., Bertram, K., Baharlou, H., Sandgren, K., Fletcher, J., Rhodes, J., Rana, H., Plasto, T., Wang, X., Lim, J., Cunningham, A., Harman, A., et al (2017). Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. Journal of Leukocyte Biology, 101(6), 1393-1403. [More Information]
Liang, F., Lindgren, G., Sandgren, K., Thompson, E., Francica, J., Seubert, A., Gregorio, E., Barnett, S., O'hagan, D., Sullivan, N., et al (2017). Vaccine priming is restricted to draining lymph nodes & controlled by adjuvant-mediated antigen uptake. Science Translational Medicine, 9(393). [More Information]

2016

Sandgren, K., Bertram, K., Cunningham, A. (2016). Understanding natural herpes simplex virus immunity to inform next-generation vaccine design. Clinical & Translational Immunology, 5, 1-8. [More Information]

2015

Salvador, A., Sandgren, K., Liang, F., Thompson, E., Koup, R., Pedraz, J., Hernandez, R., Loré, K., Igartua, M. (2015). Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses. International Journal of Pharmaceutics, 496(2), 371-381. [More Information]
Thompson, E., Liang, F., Lindgren, G., Sandgren, K., Quinn, K., Darrah, P., Koup, R., Seder, R., Kedl, R., Loré, K. (2015). Human anti-CD40 antibody and poly IC:LC adjuvant combination induces potent T cell responses in the lung of nonhuman primates. Journal of Immunology, 195(3), 1015-1024. [More Information]
Baharom, F., Thomas, S., Bieder, A., Hellmér, M., Volz, J., Sandgren, K., McInerney, G., Karlsson Hedestam, G., Mellman, I., Smed-Sörensen, A. (2015). Protection of Human myeloid dendritic cell subsets against influenza a virus infection is differentially regulated upon TLR stimulation. Journal of Immunology, 194(9), 4422-4430. [More Information]
Kim, M., Truong (Osborne), N., James, V., Bosnjak, L., Sandgren, K., Harman, A., Nasr, N., Bertram, K., Olbourne, N., Sawleshwarkar, S., Cunningham, A., et al (2015). Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. PLoS Pathogens, 11(4), 1-19. [More Information]

show 1 more

2013

Liang, F., Bond, E., Sandgren, K., Smed-Sörensen, A., Rangaka, M., Lange, C., Koup, R., McComsey, G., Lederman, M., Wilkinson, R., et al (2013). Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration. AIDS, 27(7), 1071-1080. [More Information]
Sandgren, K., Smed-Sörensen, A., Forsell, M., Soldemo, M., Adams, W., Liang, F., Perbeck, L., Koup, R., Wyatt, R., Karlsson Hedestam, G., et al (2013). Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation. Journal of Immunology, 191(1), 60-69. [More Information]
Harman, A., Bye, C., Nasr, N., Sandgren, K., Kim, M., Mercier, S., Botting, R., Lewin, S., Cunningham, A., Cameron, P. (2013). Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells. Journal of Immunology, 190(1), 66-79. [More Information]
Mercier, S., Donaghy, H., Botting, R., Turville, S., Harman, A., Nasr, N., Ji, H., Kusebauch, U., Mendoza, L., Shteynberg, D., Cunningham, A., et al (2013). The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes. PLoS Pathogens, 9(10), 1-18. [More Information]
Harman, A., Kim, M., Nasr, N., Sandgren, K., Cameron, P. (2013). Tissue dendritic cells as portals for HIV entry. Reviews in Medical Virology, 23(5), 319-333. [More Information]

show 2 more

Selected Grants

2018

Defining pathways of epithelial spread of Herpes simplex virus after genital infection, Cunningham A, Harman A, Sandgren K, National Health and Medical Research Council (NHMRC)/Project Grants

2015

Defining the Interaction of HIV with the Interferon System in Initial Mucosal Infection, Nasr N, Cunningham A, Palmer S, Harman A, Diefenbach R, Sandgren K, National Health and Medical Research Council (NHMRC)/Project Grants