People_

Professor Kim Chan

BPharm (Medal) NDMC Taipei PhD DSc Syd

Professor

Phone

+61 2 9351 3054

Fax

+61 2 9351 4391

kim.chan@sydney.edu.au

Details

Member of The University of Sydney Nano Institute

Biographical details

Hak-Kim Chan, Professor in Pharmaceutics is leading the Advanced Drug Delivery Group at the Sydney Pharmacy School. He graduated from the National Defense Medical Center (BPharm, University Medal 1983), University of Sydney (PhD 1988 and DSc 2009), was a postdoc at the University of Minnesota in 1988-89 and a scientist at Genentech Inc in 1992–95.

Research interests

Professor Chan is a world leader in respiratory drug delivery. He is globally ranked number 1 in the field of Pulmonary Drug Delivery and Inhalation Aerosols (by total number of publications and citations in the last 5 years, data from SciVal), with significant impacts in powder formulations. Over two decades since joining the University of Sydney, he has developed a leading research program on aerosol drug delivery, ranging fromin vitro production methods and characterisation of inhalation aerosols, computational modelling for powder aerosols and inhaler design to in vivo imaging study of aerosol deposition in the lungs and clinical applications. He played a pivotal role in the development of Aridol™ (inhaled mannitol for diagnosis of asthma), which was approved by the FDA in the United States, 14 European Union countries, Singapore, Malaysia, South Korea, Australia and New Zealand. The inhaled mannitol aerosol provides an important disease management tool to millions of asthma sufferers, and is particularly valuable as an objective assessment test for the early detection of asthma in young children. The second product (Bronchitol™) for mucus clearance in cystic fibrosis was also approved and marketed in Europe, Russia, Australia and the United States. This work is listed on the NHMRC website as one of the successful case studies showing its impact on raising individual and public health standard in Australia (https://www.nhmrc.gov.au/about-us/resources/impact-case-studies/aridolr-and-bronchitolr).

He has over 480 publications, including 330 original scientific papers, 92 invited review articles and book chapters, 61 referred extended conference abstracts, and one book: Advances in Pulmonary Drug Delivery, edited by Philip Kwok andHak-Kim Chan, CRC Press, Boca Raton, 2017. He has >17,580 citations and an h-index of 73 (via Google Scholar); and >13,210 citations and an h-index of 63 (via Scopus). Since 2014, he has expanded his expertise to formulation and delivery of inhaled bacteriophages as liquid and powder aerosols. He is listed as the most active author in this area with 15 scholarly outputs and 217 citations (via SciVal). Inhaled formulations offer a safe and efficient strategy to 1) combat multiple drug-resistant superbugs in respiratory infection; 2) reduce systematic toxicity due to local delivery to the lungs. He has 10 patents granted (as the first inventor in 7 patents).

Associations

Professor Chan is an Executive Editor ofAdvanced Drug Delivery Reviews (impact factor 13.3; 5 year impact factor is 15.6)and on the editorial advisory boards of various pharmaceutical journals, includingInternational Journal of Pharmaceutics andCurrent Clinical Pharmacology. He is a Fellow of the American Association of Pharmaceutical Scientists (AAPS), and Fellow of Royal Australian Chemical Institute (RACI). He was appointed to the Subcommittee on Pharmaceutical Aerosol Standards for the Australian Therapeutic Goods Administration in 1996–97, and served as a member (2007–08) on thein vitro – in vivocorrelation subgroup of the International Pharmaceutical Aerosol Consortium on Regulation and Science in Washington DC. He also served as Chair of the NSW Pharmaceutical Science Group of the RACI, and Vice President of the Asian Federation for Pharmaceutical Sciences.

Themes

Respiratory Disease

Keywords

Asthma, Chronic obstructive pulmonary disease, Cystic fibrosis, Influenza, Tuberculosis

Approaches

Chemistry, Treatment/Intervention

Clinical speciality

Respiratory

PhD and master's project opportunities

Eradicating superbugs by inhaled bacteriophages and nanomedicines

Production of nano-composite particles for inhalational delivery of combination drugs

Formulation and delivery of therapeutic phages to combat infections caused by multidrug-resistant bacteria

Current research students

Project title	Research student
Targeting pulmonary bacterial and fungal infections with inhalable repurposed drugs	Pancy KWONG
Pulmonary delivery of probiotic formulations in respiratory infections	Grace YAU

Publications

By Type

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Books

Kwok, P., Chan, H. (2016). Advances in Pulmonary Drug Delivery. Boca Raton: CRC Press. [More Information]

Book Chapters

Kwok, P., Chan, H. (2019). Solid State Testing of Inhaled Formulations. In Anthony J. Hickey, Sandro R.P. da Rocha (Eds.), Pharmaceutical Inhalation Aerosol Technology, (pp. 523-540). Boca Raton: CRC Press. [More Information]
Tong, Z., Yang, R., Chan, H., Yu, A. (2017). Multiphase Flows in Pharmaceutical Applications. In Guan Heng Yeoh, J. B. Joshi (Eds.), Handbook of Multiphase Flow Science and Technology, (pp. 1-24). Singapore: Springer. [More Information]
Zhou, Q., Qu, L., Chan, H. (2016). Pulmonary Delivery of Antibiotics for Respiratory Infections. In Philip Chi Lip Kwok, Hak-Kim Chan (Eds.), Advances in Pulmonary Drug Delivery, (pp. 131-150). Boca Raton: CRC Press. [More Information]
Wong, J., Ricci, M., Chan, H. (2016). Spray Drying Strategies to Stop Tuberculosis. In Anthony J. Hickey, Amit Misra, P. Bernard Fourie (Eds.), Drug Delivery Systems for Tuberculosis Prevention and Treatment, (pp. 161-196). New Jersey: John Wiley & Sons. [More Information]
Wang, S., Chen, M., Zhou, Q., Chan, H. (2015). Novel Formulations and Drug Delivery Systems for Phytotherapies. In Not known (Eds.), Phytotherapies: Efficacy, Safety, and Regulation, (pp. 89-100). TBC. [More Information]
Wong, J., Chan, H., Chrzanowski, W. (2014). Silk for pharmaceutical and cosmeceutical applications. In S.C Kundu (Eds.), Silk Biomaterials for Tissue Engineering and Regenerative Medicine, (pp. 519-545). Cambridge: Woodhead Publishing Limited. [More Information]
Chan, H., Kwok, P. (2013). Novel particle production technologies for inhalation products. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 47-62). Chichester, UK: John Wiley & Sons. [More Information]
Kwok, P., Salama, R., Chan, H. (2013). Proteins, peptides, and controlled-release formulations for inhalation. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 121-144). Chichester, UK: John Wiley & Sons. [More Information]
Kwok, P., Chan, H. (2011). Pulmonary Delivery of Peptides and Proteins. In Chris Van der Walle (Eds.), Peptide and Protein Delivery, (pp. 23-46). London, UK: Academic Press. [More Information]
Coates, M., Tang, P., Chan, H., Fletcher, D., Raper, J. (2009). Characterization of pharmaceutical aerosols and dry powder inhalers for pulmonary drug delivery. In Sigmund W, El-Shall H, Shah D, Moudgil B (Eds.), Particulate Systems in Nano and Biotechnologies, (pp. 193-222). Boca Raton, USA: CRC Press. [More Information]
Chan, H. (2008). Formulation challenges: protein powders for inhalation. In MJ Rathbone, J Hadgraft, MS Roberts, ME Lane (Eds.), Modified Release Drug Delivery Technology, (pp. 623-636). NY, New York: Informa Healthcare. [More Information]
Kwok, P., Chan, H. (2007). Electrostatic Charge in Pharmaceutical Systems. In James Swarbrick and James C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology, (pp. 1535-1547). New York, USA: Marcel Dekker.
Tang, P., Chan, H., Raper, J. (2004). Fractal Geometry In Pharmaceutical And Biological Applications - A Review. In James Swarbrick (Eds.), Encyclopaedia of Pharmaceutical Technology, (pp. 1779-1806). New York (on-line): Informa Healthcare.
Chan, H. (2003). Formulation challenges: Protein powders for inhalation. In Rathbone, Hadgraft, Roberts (Eds.), Modified-Release Drug Delivery Technology, Vol. 126, (pp. 879-890). United States: Marcel Dekker.

show 11 more

Journals

Milton-McGurk, L., Kourmatzis, A., Chan, H., Cheng, S., Masri, A., Farina, D. (2024). A new LED-based extinction tomography method for measurement of aerosol surface area. Journal of Aerosol Science, 181, 106432. [More Information]
Ma, Z., Milton-McGurk, L., Tang, P., Chan, H., Farina, D., Cheng, S., Kourmatzis, A. (2024). An experimental study of the effect of individual upper airway anatomical features on the deposition of dry powder inhaler formulations. Journal of Aerosol Science, 177, 106320. [More Information]
Zhu, Q., Gou, D., Chan, H., Yang, R. (2024). CFD-DEM investigation of the dispersion of elongated particles in the Turbuhaler® aerosol device. Powder Technology, 437, 119565. [More Information]
Kumar, A., Kourmatzis, A., Chan, H., Cheng, S., Singh, G. (2024). Effect of transient inhalation on powder evacuation and dispersion in a typical dual air inlet dry powder inhaler. Journal of Aerosol Science, 175, 106287. [More Information]
Gou, D., Zhu, Q., Chan, H., Kourmatzis, A., Cheng, S., Yang, R. (2024). Effects of the deformation and size of the upper airway on the deposition of aerosols. International Journal of Pharmaceutics, 657, 124165. [More Information]
Tai, W., Yau, G., Arnold, J., Chan, H., Kwok, P. (2024). High-loading cannabidiol powders for inhalation. International Journal of Pharmaceutics, 660, 124370. [More Information]
Zhang, J., Khanal, D., Chan, H., Banaszak Holl, M. (2024). Nanoscale colocalized thermal and chemical mapping of pharmaceutical powder aerosols. International Journal of Pharmaceutics, 656, 124116. [More Information]
Au-Doung, P., Li, A., Leung, S., Chan, J., Kui, O., Ho, M., Cheung, Y., Lam, J., Chan, H., Brannan, J., et al (2024). Objective monitoring tools for improved management of childhood asthma. Respiratory Research, 25(1), 194. [More Information]
Byun, A., Vitetta, L., Chan, H., Kwok, P. (2024). Respiratory Delivery of Lacticaseibacillus rhamnosus GG by Vibrating-Mesh and Jet Nebulisation. Pharmaceutics, 16(10), 1326. [More Information]
Tai, W., Arnold, J., Chan, H., Kwok, P. (2024). Spray freeze dried cannabidiol with dipalmitoylphosphatidylcholine (DPPC) for inhalation and solubility enhancement. International Journal of Pharmaceutics, 659, 124235. [More Information]
Wang, Y., Khanal, D., Alreja, A., Yang, H., Chang, R., Tai, W., Li, M., Nelson, D., Britton, W., Chan, H. (2023). Bacteriophage endolysin powders for inhaled delivery against pulmonary infections. International Journal of Pharmaceutics, 635. [More Information]
Yau, G., Tai, W., Arnold, J., Chan, H., Kwok, P. (2023). Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration. Pharmaceutical Research. [More Information]
Zhu, Q., Kakhi, M., Jayasundara, C., Walenga, R., Behara, S., Chan, H., Yang, R. (2023). CFD-DEM investigation of the effects of aperture size for a capsule-based dry powder inhaler. International Journal of Pharmaceutics, 647, 123556. [More Information]
Zhu, Q., Gou, D., Chan, H., Kourmatzis, A., Yang, R. (2023). Effects of the mouthpiece and chamber of Turbuhaler® on the aerosolization of API-only powder formulations. International Journal of Pharmaceutics, 637. [More Information]
Shen, Z., Dong, J., Milton-McGurk, L., Cai, X., Gholizadeh, H., Chan, H., Lee, A., Kourmatzis, A., Cheng, S. (2023). Numerical analysis of airflow and particle deposition in multi-fidelity designs of nasal replicas following nasal administration. Computer Methods and Programs in Biomedicine, 241, 107778. [More Information]
Khanal, D., Kim, J., Zhang, J., Ke, W., Holl, M., Chan, H. (2023). Optical photothermal infrared spectroscopy for nanochemical analysis of pharmaceutical dry powder aerosols. International Journal of Pharmaceutics, 632. [More Information]
Nang, S., Lin, Y., Petrovic Fabijan, A., Chang, R., Rao, G., Iredell, J., Chan, H., Li, J. (2023). Pharmacokinetics/pharmacodynamics of phage therapy: a major hurdle to clinical translation. Clinical Microbiology and Infection. [More Information]
Azeem, A., Singh, G., Li, L., Chan, H., Yang, R., Cheng, S., Kourmatzis, A. (2023). Quantifying Agglomerate-to-Wall Impaction in Dry Powder Inhalers. Pharmaceutical Research, 40(1), 307-319. [More Information]
Flint, R., Laucirica, D., Chan, H., Chang, B., Stick, S., Kicic, A. (2023). Stability Considerations for Bacteriophages in Liquid Formulations Designed for Nebulization. Cells, 12(16). [More Information]
Tang, P., Kakhi, M., Albariqi, A., Ravindra Babu Behara, S., Walenga, R., Yang, R., Chan, H. (2023). The role of capsule aperture size on the dispersion of carrier-based formulation at different air flowrates. International Journal of Pharmaceutics, 642. [More Information]
Cai, X., Dong, J., Milton-McGurk, L., Lee, A., Shen, Z., Chan, H., Kourmatzis, A., Cheng, S. (2023). Understanding the effects of inhaler resistance on particle deposition behaviour – A computational modelling study. Computers in Biology and Medicine, 167, 107673. [More Information]
Chang, R., Li, M., Chow, M., Ke, W., Tai, W., Chan, H. (2022). A dual action of D-amino acids on anti-biofilm activity and moisture-protection of inhalable ciprofloxacin powders. European Journal of Pharmaceutics and Biopharmaceutics, 173, 132-140. [More Information]
Chang, R., Chan, H. (2022). Advancements in Particle Engineering for Inhalation Delivery of Small Molecules and Biotherapeutics. Pharmaceutical Research, 39(12), 3047-3061. [More Information]
Wang, Y., Chang, R., Britton, W., Chan, H. (2022). Advances in the development of antimicrobial peptides and proteins for inhaled therapy. Advanced Drug Delivery Reviews, 180, 114066. [More Information]
Han, M., Nang, S., Lin, Y., Zhu, Y., Yu, H., Wickremasinghe, H., Barlow, C., Creek, D., Crawford, S., Rao, G., Chan, H., et al (2022). Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination. Computational and Structural Biotechnology Journal, 20, 485-495. [More Information]
Burchell, C., Kourmatzis, A., Zhao, Y., Raco, J., Mekonnen, T., Chan, H., Cheng, S. (2022). Effects of respiratory rate on the fluid mechanics of a reconstructed upper airway. Medical Engineering and Physics, 100, 103746. [More Information]
Leung, S., Chan, H. (2022). Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies. Advanced Drug Delivery Reviews, 191, 114594. [More Information]
Ke, W., Chang, R., Chan, H. (2022). Engineering the right formulation for enhanced drug delivery. Advanced Drug Delivery Reviews, 191. [More Information]
Singh, G., Tang, P., Cheng, S., Chan, H., Kourmatzis, A. (2022). From laminar to turbulent flow in a dry powder inhaler: The effect of simple design modifications. International Journal of Pharmaceutics, 616, 121556. [More Information]
Chan, H., Chang, R. (2022). Inhaled Delivery of Anti-Pseudomonal Phages to Tackle Respiratory Infections Caused by Superbugs. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 35(2), 73-82. [More Information]
Chang, R., Nang, S., Chan, H., Li, J. (2022). Novel antimicrobial agents for combating antibiotic-resistant bacteria. Advanced Drug Delivery Reviews, 187. [More Information]
Zhu, Q., Gou, D., Li, L., Chan, H., Yang, R. (2022). Numerical investigation of powder dispersion mechanisms in Turbuhaler and the contact electrification effect. Advanced Powder Technology, 33(11). [More Information]
Liu, C., Hong, Q., Chang, R., Kwok, P., Chan, H. (2022). Phage-Antibiotic Therapy as a Promising Strategy to Combat Multidrug-Resistant Infections and to Enhance Antimicrobial Efficiency. Antibiotics, 11(5), 570. [More Information]
Bian, X., Qu, X., Zhang, J., Nang, S., Bergen, P., Tony. Zhou, Q., Chan, H., Feng, M., Li, J. (2022). Pharmacokinetics and pharmacodynamics of peptide antibiotics. Advanced Drug Delivery Reviews, 183, 114171. [More Information]
Albariqi, A., Wang, Y., Chang, R., Quan, D., Wang, X., Kalfas, S., Drago, J., Britton, W., Chan, H. (2022). Pharmacokinetics and safety of inhaled ivermectin in mice as a potential COVID-19 treatment. International Journal of Pharmaceutics, 619, 121688. [More Information]
Li, M., Azad, M., Ahmed, M., Zhu, Y., Song, J., Zhou, F., Chan, H., Velkov, T., Zhou, Q., Li, J. (2022). Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells. Antibiotics, 11(3), 307. [More Information]
Cai, X., Ma, B., Kourmatzis, A., Salehi, F., Lee, A., Farina, D., Chan, H., Cheng, S. (2022). Potential effects of inhaler mouthpiece size on particle deposition in the human upper airway. Aerosol Science and Technology, 56(9), 802-818. [More Information]
Albariqi, A., Ke, W., Khanal, D., Kalfas, S., Tang, P., Britton, W., Drago, J., Chan, H. (2022). Preparation and Characterization of Inhalable Ivermectin Powders as a Potential COVID-19 Therapy. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 35(5), 239-251. [More Information]
Khanal, D., Ke, W., Chan, H. (2022). Raman spectroscopic evaluation of crystallinity, chemical composition and stability of pharmaceutical powder aerosols. International Journal of Pharmaceutics, 611, 121341. [More Information]
Ma, Z., Kourmatzis, A., Milton-McGurk, L., Chan, H., Farina, D., Cheng, S. (2022). Simulating the effect of individual upper airway anatomical features on drug deposition. International Journal of Pharmaceutics, 628. [More Information]
Chang, R., Chow, M., Wang, Y., Liu, C., Hong, Q., Morales, S., McLachlan, A., Kutter, E., Li, J., Chan, H. (2022). The effects of different doses of inhaled bacteriophage therapy for Pseudomonas aeruginosa pulmonary infections in mice. Clinical Microbiology and Infection, 28(7), 983-989. [More Information]
Chang, R., Okamoto, Y., Morales, S., Kutter, E., Chan, H. (2022). Topical liquid formulation of bacteriophages for metered-dose spray delivery. European Journal of Pharmaceutics and Biopharmaceutics, 177, 1-8. [More Information]
Yaqoubi, S., Chan, H., Nokhodchi, A., Dastmalchi, S., Alizadeh, A., Barzegar-Jalali, M., Adibkia, K., Hamishehkar, H. (2021). A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols. International Journal of Pharmaceutics, 602, 120568. [More Information]
Ke, W., Chang, R., Kwok, P., Tang, P., Chen, L., Chen, D., Chan, H. (2021). Administration of dry powders during respiratory supports. Annals of Translational Medicine, 9(7), 596. [More Information]
Kim, H., Chang, R., Morales, S., Chan, H. (2021). Bacteriophage-delivering hydrogels: Current progress in combating antibiotic resistant bacterial infection. Antibiotics, 10(2), 130-1-130-17. [More Information]
Ke, W., Kwok, P., Khanal, D., Chang, R., Chan, H. (2021). Co-spray dried hydrophobic drug formulations with crystalline lactose for inhalation aerosol delivery. International Journal of Pharmaceutics, 602, 120608-1-120608-10. [More Information]
Khoubnasabjafari, M., Fathi-Azarbayjani, A., Rahimpour, E., Jouyban-Gharamaleki, V., Kim, H., Alffenaar, J., Chan, H., Jouyban, A. (2021). Concentration profile of tobramycin in exhaled breath condensate after inhalation of a single dose: A pilot study. Journal of Drug Delivery Science and Technology, 62, 102394. [More Information]
Chang, R., Chow, M., Khanal, D., Chen, D., Chan, H. (2021). Dry powder pharmaceutical biologics for inhalation therapy. Advanced Drug Delivery Reviews, 172, 64-79. [More Information]
Singh, G., Lowe, A., Azeem, A., Cheng, S., Chan, H., Walenga, R., Kourmatzis, A. (2021). Effect of inflow conditioning for dry powder inhalers. International Journal of Pharmaceutics, 608, 121085-1-121085-15. [More Information]
Khanal, D., Chang, R., Hick, C., Morales, S., Chan, H. (2021). Enteric-coated bacteriophage tablets for oral administration against gastrointestinal infections. International Journal of Pharmaceutics, 609, 121206. [More Information]
Singh, G., Kourmatzis, A., Lowe, A., Masri, A., Chan, H., Cheng, S. (2021). Extending the range of back-lit imaging in two-phase flows using an interrogation-window based method. Measurement, 176, 109155. [More Information]
Elserfy, K., Kourmatzis, A., Singh, G., Chan, H., Cheng, S. (2021). Fluidization of lactose carrier powders through normally directed airflow: The effect of recirculation and particle size. Advanced Powder Technology, 32(9), 3297-3313. [More Information]
Lowe, A., Singh, G., Chan, H., Masri, A., Cheng, S., Kourmatzis, A. (2021). Fragmentation dynamics of single agglomerate-to-wall impaction. Powder Technology, 378, 561-575. [More Information]
Kwok, P., Li, D., Tang, P., Fincher, L., Browne, E., Finlay, W., Chan, H. (2021). Generation and characterization of electrostatically charged radiolabelled aerosols for lung scintigraphy. Aerosol Science and Technology, 55(6), 640-652. [More Information]
Chang, R., Okamoto, Y., Morales, S., Kutter, E., Chan, H. (2021). Hydrogel formulations containing non-ionic polymers for topical delivery of bacteriophages. International Journal of Pharmaceutics, 605, 120850-1-120850-7. [More Information]
Chow, M., Tai, W., Chang, R., Chan, H., Kwok, P. (2021). In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols. Advanced Drug Delivery Reviews, 177, 113952-1-113952-10. [More Information]
Albariqi, A., Chang, R., Tai, W., Ke, W., Chow, M., Tang, P., Kwok, P., Chan, H. (2021). Inhalable Hydroxychloroquine Powders for Potential Treatment of COVID-19. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 34(1), 20-31. [More Information]
Chow, M., Chang, R., Chan, H. (2021). Inhalation delivery technology for genome-editing of respiratory diseases. Advanced Drug Delivery Reviews, 168, 217-228. [More Information]
Chang, R., Chan, H. (2021). Lipid nanoparticles for the inhalation of mRNA. Nature Biomedical Engineering, 5(9), 949-950. [More Information]
Elserfy, K., Cheng, S., Chan, H., Kourmatzis, A. (2021). Local dynamics of pharmaceutical powder fluidization using high speed long distance microscopy and particle image velocimetry. Experimental Thermal and Fluid Science, 124, 110367. [More Information]
Khatib, I., Chow, M., Ruan, J., Cipolla, D., Chan, H. (2021). Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design. International Journal of Pharmaceutics, 597, 120277. [More Information]
Tai, W., Chow, M., Chang, R., Tang, P., Chan, H., Kwok, P. (2021). Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19. Pharmaceutics, 13(8), 1260. [More Information]
Li, M., Chang, R., Lin, Y., Morales, S., Kutter, E., Chan, H. (2021). Phage cocktail powder for Pseudomonas aeruginosa respiratory infections. International Journal of Pharmaceutics, 596, 120200. [More Information]
Iszatt, J., Larcombe, A., Chan, H., Stick, S., Garratt, L., Kicic, A. (2021). Phage therapy for multi-drug resistant respiratory tract infections. Viruses, 13(9), 1809. [More Information]
Chow, M., Chang, R., Li, M., Wang, Y., Lin, Y., Morales, S., McLachlan, A., Kutter, E., Li, J., Chan, H. (2021). Pharmacokinetics and time-kill study of inhaled antipseudomonal bacteriophage therapy in mice. Antimicrobial Agents and Chemotherapy, 65(1), e01470-20-1-e01470-20-12. [More Information]
Ahmed, M., Azad, M., Li, M., Creek, D., Han, M., Zhou, F., Chan, H., Zhou, Q., Velkov, T., Li, J. (2021). Polymyxins induced metabolic perturbations in human lung epithelial cells. Antimicrobial Agents and Chemotherapy, 65(9), e00835-21-1-e00835-21-13. [More Information]
Khatib, I., Ke, W., Cipolla, D., Chan, H. (2021). Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin nanocrystal-containing liposomes. International Journal of Pharmaceutics, 605, 120809-1-120809-12. [More Information]
Lin, Y., Quan, D., Chang, R., Chow, M., Wang, Y., Li, M., Morales, S., Britton, W., Kutter, E., Li, J., Chan, H. (2021). Synergistic activity of phage PEV20-ciprofloxacin combination powder formulation—A proof-of-principle study in a P. aeruginosa lung infection model. European Journal of Pharmaceutics and Biopharmaceutics, 158, 166-171. [More Information]
Khanal, D., Zhang, J., Ke, W., Banaszak Holl, M., Chan, H. (2020). Bulk to Nanometer-Scale Infrared Spectroscopy of Pharmaceutical Dry Powder Aerosols. Analytical Chemistry, 92(12), 8323-8332. [More Information]
Wang, Y., Khanal, D., Chang, R., Shang, X., Yang, H., Britton, W., Nelson, D., Chan, H. (2020). Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae? International Journal of Pharmaceutics, 591, 1-8. [More Information]
Chang, R., Kwok, P., Ghassabian, S., Brannan, J., Koskela, H., Chan, H. (2020). Cough as an adverse effect on inhalation pharmaceutical products. British Journal of Pharmacology, 177(18), 4096-4112. [More Information]
Elserfy, K., Kourmatzis, A., Chan, H., Walenga, R., Cheng, S. (2020). Effect of an upstream grid on the fluidization of pharmaceutical carrier powders. International Journal of Pharmaceutics, 578, 1-10. [More Information]
Khatib, I., Tang, P., Ruan, J., Cipolla, D., Dayton, F., Blanchard, J., Chan, H. (2020). Formation of ciprofloxacin nanocrystals within liposomes by spray drying for controlled release via inhalation. International Journal of Pharmaceutics, 578, 119045. [More Information]
Marqus, S., Lee, L., Istivan, T., Kyung Chang, R., Dekiwadia, C., Chan, H., Yeo, L. (2020). High frequency acoustic nebulization for pulmonary delivery of antibiotic alternatives against Staphylococcus aureus. European Journal of Pharmaceutics and Biopharmaceutics, 151, 181-188. [More Information]
Newman, S., Chan, H. (2020). In vitro-in vivo correlations (IVIVCs) of deposition for drugs given by oral inhalation. Advanced Drug Delivery Reviews, 167, 135-147. [More Information]
Kwok, P., McDonnell, A., Tang, P., Knight, C., McKay, E., Butler, S., Sivarajah, A., Quinn, R., Fincher, L., Browne, E., Chan, H., et al (2020). In vivo deposition study of a new generation nebuliser utilising hybrid resonant acoustic (HYDRA) technology. International Journal of Pharmaceutics, 580, 119196. [More Information]
Chang, R., Kwok, P., Khanal, D., Morales, S., Kutter, E., Li, J., Chan, H. (2020). Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization. Bioengineering & Translational Medicine, 5(2), 1-10. [More Information]
Samini, L., Khoubnasabjafari, M., Alimorad, M., Jouyban-Gharamaleki, V., Chan, H., Jouyban, A. (2020). Microextraction and chromatographic analysis of budesonide epimers in exhaled breath condensate. Current Analytical Chemistry, 16(8), 1032-1040. [More Information]
Khanal, D., Khatib, I., Ruan, J., Cipolla, D., Drayton, F., Blanchard, J., Chan, H., Chrzanowski, W. (2020). Nanoscale Probing of Liposome Encapsulating Drug Nanocrystal Using Atomic Force Microscopy-Infrared Spectroscopy. Analytical Chemistry, 92(14), 9922-9931. [More Information]
Yu, S., Yuan, H., Chai, G., Peng, K., Zou, P., Li, X., Li, J., Zhou, F., Chan, H., Zhou, Q. (2020). Optimization of inhalable liposomal powder formulations and evaluation of their in vitro drug delivery behavior in Calu-3 human lung epithelial cells. International Journal of Pharmaceutics, 586, 119570. [More Information]
Chang, R., Chen, L., Chen, D., Chan, H. (2020). Overcoming challenges for development of amorphous powders for inhalation. Expert Opinion on Drug Delivery, 17(11), 1583-1595. [More Information]
Lin, Y., Chang, R., Rao, G., Jermain, B., Han, M., Zhao, J., Chen, K., Wang, J., Barr, J., Schooley, R., Chan, H., et al (2020). Pharmacokinetics/pharmacodynamics of antipseudomonal bacteriophage therapy in rats: a proof-of-concept study. Clinical Microbiology and Infection, 26(9), 1229-1235. [More Information]
Sato, H., Kaneko, Y., Yamada, K., Ristroph, K., Lu, H., Seto, Y., Chan, H., Prud'homme, R., Onoue, S. (2020). Polymeric Nanocarriers With Mucus-Diffusive and Mucus-Adhesive Properties to Control Pharmacokinetic Behavior of Orally Dosed Cyclosporine A. Journal of Pharmaceutical Sciences, 109(2), 1079-1085. [More Information]
Ma, B., Kourmatzis, A., Zhao, Y., Yang, R., Chan, H., Salehi, F., Cheng, S. (2020). Potential effects of lingual fats on airway flow dynamics and particle deposition. Aerosol Science and Technology, 54(3), 321-331. [More Information]
Chow, M., Kwok, P., Yang, R., Chan, H. (2020). Predicting the composition and size distribution of dry particles for aerosols and sprays of suspension: A Monte Carlo approach. International Journal of Pharmaceutics, 582, 119311. [More Information]
Ke, W., Chang, R., Kwok, P., Chen, D., Chan, H. (2020). Spray drying lactose from organic solvent suspensions for aerosol delivery to the lungs. International Journal of Pharmaceutics, 591, 119984. [More Information]
Lin, Y., Chang, R., Britton, W., Morales, S., Kutter, E., Li, J., Chan, H. (2020). Storage stability of phage-ciprofloxacin combination powders against Pseudomonas aeruginosa respiratory infections. International Journal of Pharmaceutics, 591, 119952. [More Information]
Shetty, N., Zhang, Y., Park, H., Zemlyanov, D., Shah, D., He, A., Ahn, P., Mutukuri, T., Chan, H., Zhou, Q. (2020). Surface Composition and Aerosolization Stability of an Inhalable Combinational Powder Formulation Spray Dried Using a Three-Fluid Nozzle. Pharmaceutical Research, 37(11), 219. [More Information]
Zhao, Y., Raco, J., Kourmatzis, A., Diasinos, S., Chan, H., Yang, R., Cheng, S. (2020). The effects of upper airway tissue motion on airflow dynamics. Journal of Biomechanics, 99, 109506. [More Information]
Chang, R., Morales, S., Okamoto, Y., Chan, H. (2020). Topical application of bacteriophages for treatment of wound infections. Translational Research: the journal of laboratory and clinical medicine, 220, 153-166. [More Information]
Lin, Y., Aye, S., Rao, G., Zhou, Q., Chan, H., Li, J. (2020). Treatment of infections caused by Gram-negative pathogens: current status on the pharmacokinetics/pharmacodynamics of parenteral and inhaled polymyxins in patients. International Journal of Antimicrobial Agents, 56(6), 106199. [More Information]
An Le, N., Deng, H., Devendran, C., Akhtar, N., Ma, X., Pouton, C., Chan, H., Neild, A., Alan, T. (2020). Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis. Lab on a Chip, 20(3), 582-591. [More Information]
Khoubnasabjafari, M., Rahimpour, E., Samini, M., Jouyban-Gharamaleki, V., Chen, L., Chen, D., Chan, H., Jouyban, A. (2019). A new hypothesis to investigate bioequivalence of pharmaceutical inhalation products. DARU Journal of Pharmaceutical Sciences, 27(1), 517-524. [More Information]
Wallin, M., Tang, P., Chang, R., Yang, M., Finlay, W., Chan, H. (2019). Aerosol drug delivery to the lungs during nasal high flow therapy: an in vitro study. BMC Pulmonary Medicine, 19(1), 1-11. [More Information]
Abdelghany, S., Parumasivam, T., Pang, A., Roediger, B., Tang, P., Jahn, K., Britton, W., Chan, H. (2019). Alginate modified-PLGA nanoparticles entrapping amikacin and moxifloxacin as a novel host-directed therapy for multidrug-resistant tuberculosis. Journal of Drug Delivery Science and Technology, 52, 642-651. [More Information]
Lu, W., Rades, T., Rantanen, J., Chan, H., Yang, M. (2019). Amino acids as stabilizers for spray-dried simvastatin powder for inhalation. International Journal of Pharmaceutics, 572, 1-12. [More Information]
Chang, R., Das, T., Manos, J., Kutter, E., Morales, S., Chan, H. (2019). Bacteriophage PEV20 and Ciprofloxacin Combination Treatment Enhances Removal of Pseudomonas aeruginosa Biofilm Isolated from Cystic Fibrosis and Wound Patients. The AAPS Journal, 21(3), 1-8. [More Information]
Kim, Y., Tong, Z., Chan, H., Yang, R. (2019). CFD modelling of air and particle flows in different airway models. Journal of Aerosol Science, 134, 14-28. [More Information]
Khatib, I., Khanal, D., Ruan, J., Cipolla, D., Dayton, F., Blanchard, J., Chan, H. (2019). Ciprofloxacin nanocrystals liposomal powders for controlled drug release via inhalation. International Journal of Pharmaceutics, 566, 641-651. [More Information]
Cheng, S., Kourmatzis, A., Mekonnen, T., Gholizadeh, H., Raco, J., Chen, L., Tang, P., Chan, H. (2019). Does upper airway deformation affect drug deposition? International Journal of Pharmaceutics, 572, 2-8. [More Information]
Mahmoudi, S., Elserfy, K., Cheng, S., Chan, H., Hebbink, G., Kourmatzis, A. (2019). Fluidisation characteristics of lactose powders in simple turbulent channel flows. Experimental Thermal and Fluid Science, 103, 201-213. [More Information]
Khanal, D., Chang, R., Morales, S., Chan, H., Chrzanowski, W. (2019). High Resolution Nanoscale Probing of Bacteriophages in an Inhalable Dry Powder Formulation for Pulmonary Infections. Analytical Chemistry, 91(20), 12760-12767. [More Information]
Chow, M., Qiu, Y., Liao, Q., Kwok, P., Chow, S., Chan, H., Lam, J. (2019). High siRNA loading powder for inhalation prepared by co-spray drying with human serum albumin. International Journal of Pharmaceutics, 572, 1-11. [More Information]
Lin, Y., Chang, R., Britton, W., Morales, S., Cutter, E., Li, J., Chan, H. (2019). Inhalable combination powder formulations of phage and ciprofloxacin for P. aeruginosa respiratory infections. European Journal of Pharmaceutics and Biopharmaceutics, 142, 543-552. [More Information]
Ahmed, M., Velkov, T., Zhou, Q., Fulcher, A., Callaghan, J., Zhou, F., Chan, H., Azad, M., Li, J. (2019). Intracellular localization of polymyxins in human alveolar epithelial cells. Journal of Antimicrobial Chemotherapy, 74(1), 48-57. [More Information]
Leung, S., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Carter, E., Britton, W., Kutter, E., Chan, H. (2019). Jet nebulization of bacteriophages with different tail morphologies - Structural effects. International Journal of Pharmaceutics, 554, 322-326. [More Information]
Liao, Q., Yip, L., Chow, M., Chow, S., Chan, H., Kwok, P., Lam, J. (2019). Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition. International Journal of Pharmaceutics, 560, 144-154. [More Information]
Ashish Kumar, T., Choong, H., Kwang, Y., Chan, H., Manos, J., Kwok, P., Duong, H. (2019). Spray-Dried Particles of Nitric Oxide-Modified Glutathione for the Treatment of Chronic Lung Infection. Molecular Pharmaceutics, 16(4), 1723-1731. [More Information]
Chang, R., Wallin, M., Kutter, E., Morales, S., Britton, W., Li, J., Chan, H. (2019). Storage stability of inhalable phage powders containing lactose at ambient conditions. International Journal of Pharmaceutics, 560, 11-18. [More Information]
Kwok, P., Chan, H., Wallin, M., Dolovich, M. (2019). Studies of Radioaerosol Deposition in the Respiratory Tract. Seminars in Nuclear Medicine, 49(1), 62-70. [More Information]
Mangal, S., Xu, R., Park, H., Zemlyanov, D., Shetty, N., Lin, Y., Morton, D., Chan, H., Li, J., Zhou, Q. (2019). Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation. Pharmaceutical Research, 36(1), 1-15. [More Information]
Dhanani, J., Cohen, J., Parker, S., Chan, H., Tang, P., Ahern, B., Khan, A., Bhatt, M., Goodman, S., Diab, S., et al (2018). A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models. Intensive Care Medicine Experimental, 6(1), 1-19. [More Information]
Le, N., Phan, H., Yu, J., Chan, H., Neild, A., Alan, T. (2018). Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers. International Journal of Nanomedicine, 13, 1353-1359. [More Information]
Reczynska, K., Tharkar, P., Kim, S., Wang, Y., Pamula, E., Chan, H., Chrzanowski, W. (2018). Animal Models of Smoke Inhalation Injury and Related Acute and Chronic Lung Diseases. Advanced Drug Delivery Reviews, 123, 107-134. [More Information]
Dhanani, J., Tang, P., Wallis, S., Parker, S., Pandey, P., Fraser, J., Cohen, J., Barnett, A., Roberts, J., Chan, H. (2018). Characterisation of 40mg/ml and 100mg/ml tobramycin formulations for aerosol therapy with adult mechanical ventilation. Pulmonary Pharmacology & Therapeutics, 50, 93-99. [More Information]
Wallin, M., Turner, P., Katsifis, A., Yang, M., Chan, H. (2018). Crystal structure of aqua(2-{[2-({2-[bis(carboxylato-kappa O-methyl)amino-kappa N]ethyl}(carboxylato-kappa O-methyl) amino-kappa N)ethyl](carboxymethyl)azanium-yl}acetato)gallium(III) trihydrate. Acta Crystallographica Section E, E74, 1054-1057. [More Information]
Leung, S., Parumasivam, T., Nguyen, A., Gegenbach, T., Carter, E., Carrigy, N., Wang, H., Vehring, R., Finlay, W., Morales, S., Britton, W., Chan, H., et al (2018). Effect of storage temperature on the stability of spray dried bacteriophage powders. European Journal of Pharmaceutics and Biopharmaceutics, 127, 213-222. [More Information]
Lin, Y., Zhou, Q., Han, M., Chen, K., Onufrak, N., Wang, J., Turnidge, J., Howden, B., Forrest, A., Chan, H., et al (2018). Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy, 62(2), 1-9. [More Information]
Lee, S., Heng, D., Xavier, V., Chan, K., Ng, W., Zhao, Y., Chan, H., Tan, R. (2018). Inhaled non-steroidal polyphenolic alternatives for anti-inflammatory combination therapy. Powder Technology, 339, 244-255. [More Information]
Lin, Y., Zhou, Q., Han, M., Onufrak, N., Chen, K., Wang, J., Forrest, A., Chan, H., Li, J. (2018). Mechanism-based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy, 62(3), 1-14. [More Information]
Leung, S., Morales, S., Britton, W., Kutter, E., Chan, H. (2018). Microfluidic-assisted bacteriophage encapsulation into liposomes. International Journal of Pharmaceutics, 545(1-Feb), 176-182. [More Information]
Astudillo, A., Leung, S., Kutter, E., Morales, S., Chan, H. (2018). Nebulization effects on structural stability of bacteriophage PEV 44. European Journal of Pharmaceutics and Biopharmaceutics, 125, 124-130. [More Information]
Ye, T., Sun, S., Sugianto, T., Tang, P., Parumasivam, T., Chang, R., Astudillo, A., Wang, S., Chan, H. (2018). Novel combination proliposomes containing tobramycin and clarithromycin effective against Pseudomonas aeruginosa biofilms. International Journal of Pharmaceutics, 552(1-Feb), 130-138. [More Information]
Dong, J., Shang, Y., Inthavong, K., Chan, H., Tu, J. (2018). Numerical Comparison of Nasal Aerosol Administration Systems for Efficient Nose-to-Brain Drug Delivery. Pharmaceutical Research, 35(5), 1-12. [More Information]
Dong, J., Shang, Y., Inthavong, K., Chan, H., Tu, J. (2018). Partitioning of dispersed nanoparticles in a realistic nasal passage for targeted drug delivery. International Journal of Pharmaceutics, 543, 83-95. [More Information]
Chang, R., Wallin, M., Lin, Y., Leung, S., Wang, H., Morales, S., Chan, H. (2018). Phage therapy for respiratory infections. Advanced Drug Delivery Reviews, 133, 76-86. [More Information]
Ashhurst, A., Parumasivam, T., Chan, J., Lin, L., Florido, M., West, N., Chan, H., Britton, W. (2018). PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection. PloS One, 13(3). [More Information]
Chang, R., Chen, K., Wang, J., Wallin, M., Britton, W., Morales, S., Kutter, E., Li, J., Chan, H. (2018). Proof-of-Principle Study in a Murine Lung Infection Model of Antipseudomonal Activity of Phage PEV20 in a Dry-Powder Formulation. Antimicrobial Agents and Chemotherapy, 62(2), 1-8. [More Information]
Yu, J., Romeo, M., Cavallaro, A., Chan, H. (2018). Protective effect of sodium stearate on the moisture-induced deterioration of hygroscopic spray-dried powders. International Journal of Pharmaceutics, 541(1-2), 11-18. [More Information]
Wallin, M., Takami, T., Chen, L., Yang, M., Chan, H. (2018). Pulmonary drug delivery to older people. Advanced Drug Delivery Reviews, 135, 50-61. [More Information]
Anderson, S., Daviskas, E., Brannan, J., Chan, H. (2018). Repurposing excipients as active inhalation agents: The mannitol story. Advanced Drug Delivery Reviews, 133, 45-56. [More Information]
Lin, Y., Chang, R., Britton, W., Morales, S., Kutter, E., Chan, H. (2018). Synergy of nebulized phage PEV20 and ciprofloxacin combination against Pseudomonas aeruginosa. International Journal of Pharmaceutics, 551, 158-165. [More Information]
Lu, X., Chan, T., Zhu, L., Bao, X., Velkov, T., Zhou, Q., Li, J., Chan, H., Zhou, F. (2018). The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models. European Journal of Pharmaceutical Sciences, 115, 132-143. [More Information]
Liang, W., Chow, M., Chow, S., Chan, H., Kwok, P., Lam, J. (2018). Using Two-Fluid Nozzle for Spray Freeze Drying to Produce Porous Powder Formulation of Naked siRNA for Inhalation. International Journal of Pharmaceutics, 552(1-2), 67-75. [More Information]
Feng, B., Tang, P., Leung, S., Dhanani, J., Chan, H. (2017). A Novel In-Line Delivery System to Administer Dry Powder Mannitol to Mechanically Ventilated Patients. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30(2), 100-107. [More Information]
Lin, Y., Zhou, Q., Onufrak, N., Wirth, V., Chen, K., Wang, J., Forrest, A., Chan, H., Li, J. (2017). Aerosolized polymyxin B for treatment of respiratory tract infections: Determination of pharmacokinetic-pharmacodynamic indices for aerosolized polymyxin B against Pseudomonas aeruginosa in a mouse lung infection model. Antimicrobial Agents and Chemotherapy, 61(8), 1-15. [More Information]
Kourmatzis, A., Cheng, S., Chan, H. (2017). Airway geometry, airway flow, and particle measurement methods: implications on pulmonary drug delivery. Expert Opinion on Drug Delivery, 15(3), 271-282. [More Information]
Carrigy, N., Chang, R., Leung, S., Harrison, M., Petrova, Z., Pope, W., Hatfull, G., Britton, W., Chan, H., Sauvageau, D., et al (2017). Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler. Pharmaceutical Research, 34(10), 2084-2096. [More Information]
Zhang, Y., Feng, J., McManus, S., Lu, H., Ristroph, K., Cho, E., Dobrijevic, E., Chan, H., Prud'homme, R. (2017). Design and Solidification of Fast-Releasing Clofazimine Nanoparticles for Treatment of Cryptosporidiosis. Molecular Pharmaceutics, 14(10), 3480-3488. [More Information]
Yu, J., Wong, J., Ukkonen, A., Kannosto, J., Chan, H. (2017). Effect of Relative Humidity on Bipolar Electrostatic Charge Profiles of dry Powder Aerosols. Pharmaceutical Research, 34(8), 1707-1715. [More Information]
Leung, S., Chiow, A., Kwok, P., Ukkonen, A., Chan, H. (2017). Effect of Spacers on the Bipolar Electrostatic Charge Properties of Metered Dose Inhaler Aerosols—A Case Study With Tilade. Journal of Pharmaceutical Sciences, 106(6), 1553-1559. [More Information]
Leung, S., Parumasivam, T., Gao, G., Carter, E., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Britton, W., Kutter, E., Chan, H. (2017). Effects of storage conditions on the stability of spray dried, inhalable bacteriophage powders. International Journal of Pharmaceutics, 521(1-2), 141-149. [More Information]
Yang, M., Ruzycki, C., Verschuer, J., Katsifis, A., Eberl, S., Wong, K., Golshahi, L., Brannan, J., Finlay, W., Chan, H. (2017). Examining the ability of empirical correlations to predict subject specific in vivo extrathoracic aerosol deposition during tidal breathing. Aerosol Science and Technology, 51(3), 363-376. [More Information]
Ruzycki, C., Yang, M., Chan, H., Finlay, W. (2017). Improved prediction of intersubject variability in extrathoracic aerosol deposition using algebraic correlations. Aerosol Science and Technology, 51(6), 667-673. [More Information]
Ye, T., Yu, J., Luo, Q., Wang, S., Chan, H. (2017). Inhalable clarithromycin liposomal dry powders using ultrasonic spray freeze drying. Powder Technology, 305, 63-70. [More Information]
Parumasivam, T., Ashhurst, A., Nagalingam, G., Britton, W., Chan, H. (2017). Inhalation of Respirable Crystalline Rifapentine Particles Induces Pulmonary Inflammation. Molecular Pharmaceutics, 14(1), 328-335. [More Information]
Chow, M., Qiu, Y., Lo, F., Lin, H., Chan, H., Kwok, P., Lam, J. (2017). Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer. International Journal of Pharmaceutics, 530(1-2), 40-52. [More Information]
Jahedi, L., Downie, S., Saini, B., Chan, H., Bosnic-Anticevich, S. (2017). Inhaler Technique in Asthma: How Does It Relate to Patients' Preferences and Attitudes Toward Their Inhalers? Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30(1), 42-52. [More Information]
Li, L., Leung, S., Gengenbach, T., Yu, J., Gao, G., Tang, P., Zhou, Q., Chan, H. (2017). Investigation of L-leucine in reducing the moisture-induced deterioration of spray-dried salbutamol sulfate power for inhalation. International Journal of Pharmaceutics, 530(1-2), 30-39. [More Information]
Reslan, M., Demir, Y., Trout, B., Chan, H., Kayser, V. (2017). Lack of a synergistic effect of arginine–glutamic acid on the physical stability of spray-dried bovine serum albumin. Pharmaceutical Development and Technology, 22(6), 785-791. [More Information]
Yang, M., Chan, H. (2017). Monitoring the Inhalation Flow Rate of Nebulized Aerosols Using an Ultrasonic Flow Meter: In Vitro Assessment. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30(3), 173-181. [More Information]
Suzuki, H., Hamao, S., Seto, Y., Sato, H., Wong, J., Prud'homme, R., Chan, H., Onoue, S. (2017). New nano-matrix oral formulation of nanoprecipitated cyclosporine A prepared with multi-inlet vortex mixer. International Journal of Pharmaceutics, 516(1-2), 116-119. [More Information]
Saboti, D., Maver, U., Chan, H., Planinsek, O. (2017). Novel Budesonide Particles for Dry Powder Inhalation Prepared Using a Microfluidic Reactor Coupled With Ultrasonic Spray Freeze Drying. Journal of Pharmaceutical Sciences, 106(7), 1881-1888. [More Information]
Lin, Y., Zhou, Q., Cheah, S., Zhao, J., Chen, K., Wang, J., Chan, H., Li, J. (2017). Pharmacokinetics/pharmacodynamics of pulmonary delivery of colistin against Pseudomonas aeruginosa in a mouse lung infection model. Antimicrobial Agents and Chemotherapy, 61(3). [More Information]
Leung, S., Wong, J., Guerra, H., Samnick, K., Prud’homme, R., Chan, H. (2017). Porous mannitol carrier for pulmonary delivery of cyclosporine A nanoparticles. The AAPS Journal, 19(2), 578-586. [More Information]
Ahmed, M., Velkov, T., Lin, Y., Yun, B., Nowell, C., Zhou, F., Zhou, Q., Chan, H., Azad, M., Li, J. (2017). Potential Toxicity of Polymyxins in Human Lung Epithelial Cells. Antimicrobial Agents and Chemotherapy, 61(6), 1-12. [More Information]
Okuda, T., Tang, P., Yu, J., Finlay, W., Chan, H. (2017). Powder aerosol delivery through nasal high-flow system: In vitro feasibility and influence of process conditions. International Journal of Pharmaceutics, 533(1), 187-197. [More Information]
Chang, R., Wong, J., Mathai, A., Morales, S., Kutter, E., Britton, W., Li, J., Chan, H. (2017). Production of highly stable spray dried phage formulations for treatment of Pseudomonas aeruginosa lung infection. European Journal of Pharmaceutics and Biopharmaceutics, 121, 1-13. [More Information]
Yu, J., Chan, H., Gengenbach, T., Denman, J. (2017). Protection of hydrophobic amino acids against moisture-induced deterioration in the aerosolization performance of highly hygroscopic spray-dried powders. European Journal of Pharmaceutics and Biopharmaceutics, 119, 224-234. [More Information]
Lin, Y., Zhou, Q., Hu, Y., Onufrak, N., Sun, S., Wang, J., Forrest, A., Chan, H., Li, J. (2017). Pulmonary Pharmacokinetics of colistin following administration of dry powder aerosols in rats. Antimicrobial Agents and Chemotherapy, 61(11), 1-12. [More Information]
Parumasivam, T., Leung, S., Tang, P., Mauro, C., Britton, W., Chan, H. (2017). The Delivery of High-Dose Dry Powder Antibiotics by a Low-Cost Generic Inhaler. The AAPS Journal, 19(1), 191-202. [More Information]
Lu, X., Chen, L., Wu, C., Chan, H., Freeman, T. (2017). The effects of relative humidity on the flowability and dispersion performance of lactose mixtures. Materials, 10(6), 1-9. [More Information]
Leung, S., Parumasivam, T., Tang, P., Chan, H. (2016). A Proof-of-Principle Setup for Delivery of Relenza (Zanamivir) Inhalation Powder to Intubated Patients. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(1), 30-35. [More Information]
Chen, L., Okuda, T., Lu, X., Chan, H. (2016). Amorphous powders for inhalation drug delivery. Advanced Drug Delivery Reviews, 100, 102-115. [More Information]
Leung, S., Chiow, A., Ukkonen, A., Chan, H. (2016). Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs). Pharmaceutical Research, 33(2), 283-291. [More Information]
Kim, S., Burgess, J., Wang, Y., Kable, E., Weiss, D., Chan, H., Chrzanowski, W. (2016). Atomized Human Amniotic Mesenchymal Stromal Cells for Direct Delivery to the Airway for Treatment of Lung Injury. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(6), 514-524. [More Information]
Sato, H., Suzuki, H., Yakushiji, K., Wong, J., Seto, Y., Prud'homme, R., Chan, H., Onoue, S. (2016). Biopharmaceutical Evaluation of Novel Cyclosporine A Nano-matrix Particles for Inhalation. Pharmaceutical Research, 33(9), 2107-2116. [More Information]
Wong, J., Kwok, P., Niemela, V., Heng, D., Crapper, J., Chan, H. (2016). Bipolar electrostatic charge and mass distributions of powder aerosols - Effects of inhaler design and inhaler material. Journal of Aerosol Science, 95, 104-117. [More Information]
Tong, Z., Zhong, W., Yu, A., Chan, H., Yang, R. (2016). CFD-DEM investigation of the effect of agglomerate-agglomerate collision on dry powder aerosolisation. Journal of Aerosol Science, 92, 109-121. [More Information]
Ung, K., Rao, N., Weers, J., Huang, D., Chan, H. (2016). Design of spray dried insulin microparticles to bypass deposition in the extrathoracic region and maximize total lung dose. International Journal of Pharmaceutics, 511(2), 1070-1079. [More Information]
Seto, Y., Suzuki, G., Leung, S., Chan, H., Onoue, S. (2016). Development of an Improved Inhalable Powder Formulation of Pirfenidone by Spray-Drying: In Vitro Characterization and Pharmacokinetic Profiling. Pharmaceutical Research, 33(6), 1447-1455. [More Information]
Parumasivam, T., Chang, R., Abdelghany, S., Ye, T., Britton, W., Chan, H. (2016). Dry powder inhalable formulations for anti-tubercular therapy. Advanced Drug Delivery Reviews, 102, 83-101. [More Information]
Ung, K., Chan, H. (2016). Effects of ramp-up of inspired airflow on in vitro aerosol dose delivery performance for certain dry powder inhalers. European Journal of Pharmaceutical Sciences, 84, 46-54. [More Information]
Wang, W., Zhou, Q., Sun, S., Denman, J., Gengenbach, T., Barraud, N., Rice, S., Li, J., Yang, M., Chan, H. (2016). Effects of Surface Composition on the Aerosolisation and Dissolution of Inhaled Antibiotic Combination Powders Consisting of Colistin and Rifampicin. The AAPS Journal, 18(2), 372-384. [More Information]
Cipolla, D., Wu, H., Salentinig, S., Boyd, B., Rades, T., Vanhecke, D., Fink-Petri, A., Rothin-Rutishauser, B., Eastman, S., Redelmeier, T., Chan, H., et al (2016). Formation of drug nanocrystals under nanoconfinement afforded by liposomes. RSC Advances, 6(8), 6223-6233. [More Information]
Dhanani, J., Fraser, J., Chan, H., Rello, J., Cohen, J., Roberts, J. (2016). Fundamentals of aerosol therapy in critical care. Critical Care, 20(1), 1-16. [More Information]
Zhou, Q., Loh, Z., Yu, J., Sun, S., Gengenbach, T., Denman, J., Li, J., Chan, H. (2016). How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder? The AAPS Journal, 18(5), 1213-1224. [More Information]
Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, H., Li, J., Zhou, F. (2016). Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins. Journal of Antimicrobial Chemotherapy, 71(2), 403-412. [More Information]
Parumasivam, T., Chan, J., Pang, A., Quan, D., Triccas, J., Britton, W., Chan, H. (2016). In Vitro Evaluation of Inhalable Verapamil-Rifapentine Particles for Tuberculosis Therapy. Molecular Pharmaceutics, 13(3), 979-989. [More Information]
Parumasivam, T., Chan, J., Pang, A., Quan, D., Triccas, J., Britton, W., Chan, H. (2016). In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment. European Journal of Pharmaceutics and Biopharmaceutics, 107, 205-214. [More Information]
Sugianto, T., Chan, H. (2016). Inhaled antibiotics in the treatment of non-cystic fibrosis bronchiectasis: Clinical and drug delivery perspectives. Expert Opinion on Drug Delivery, 13(1), 7-22. [More Information]
Li, L., Sun, S., Parumasivam, T., Denman, J., Gengenbach, T., Tang, P., Mao, S., Chan, H. (2016). L-Leucine as an excipient against moisture on in vitro aerosolization performances of highly hygroscopic spray-dried powders. European Journal of Pharmaceutics and Biopharmaceutics, 102, 132-141. [More Information]
Leung, S., Parumasivam, T., Gao, G., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Britton, W., Kutter, E., Chan, H. (2016). Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections. Pharmaceutical Research, 33(6), 1486-1496. [More Information]
Jin, L., Zhou, Q., Chan, H., Larson, I., Pennington, M., Morales, R., Boyd, B., Norton, R., Nicolazzo, J. (2016). Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases. Journal of Pharmaceutical Sciences, 105(2), 650-656. [More Information]
Leung, S., Parumasivam, T., Tang, P., Chan, H. (2016). Response to Letter to the Editor: Pulmonary Delivery of Dry Powders During Invasive Mechanical Ventilation: Innovations Are Required. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(2), 217-217. [More Information]
Parumasivam, T., Leung, S., Quan, D., Triccas, J., Britton, W., Chan, H. (2016). Rifapentine-loaded PLGA microparticles for tuberculosis inhaled therapy: Preparation and in vitro aerosol characterization. European Journal of Pharmaceutical Sciences, 88, 1-11. [More Information]
Yang, M., Verschuer, J., Shi, Y., Song, Y., Katsifis, A., Eberl, S., Wong, K., Brannan, J., Cai, W., Finlay, W., Chan, H. (2016). The effect of device resistance and inhalation flow rate on the lung deposition of orally inhaled mannitol dry powder. International Journal of Pharmaceutics, 513(1-2), 294-301. [More Information]
Cipolla, D., Wu, H., Eastman, S., Redelmeier, T., Gonda, I., Chan, H. (2016). Tuning Ciprofloxacin Release Profiles from Liposomally Encapsulated Nanocrystalline Drug. Pharmaceutical Research, 33(11), 2748-2762. [More Information]
Leung, C., Tong, Z., Zhou, Q., Chan, J., Tang, P., Sun, S., Yang, R., Chan, H. (2016). Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-Based DPI Formulations. Part 1: Grid Structure. The AAPS Journal, 18(5), 1159-1167. [More Information]
Lee, S., Teo, J., Heng, D., Zhao, Y., Ng, W., Chan, H., Tan, L., Tan, R. (2015). A novel inhaled multi-pronged attack against respiratory bacteria. European Journal of Pharmaceutical Sciences, 70, 37-44. [More Information]
D'Sa, D., Chan, H. (2015). A Review of Methods for Evaluating Particle Stability in Suspension Based Pressurized Metered Dose Inhalers. Current Pharmaceutical Design, 21(27), 3955-3965. [More Information]
Cipolla, D., Wu, H., Gonda, I., Chan, H. (2015). Aerosol performance and stability of liposomes containing ciprofloxacin nanocrystals. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28(6), 411-422. [More Information]
Tang, P., Leung, S., Hor, E., Ruzycki, C., Carrigy, N., Finlay, W., Brannan, J., Devadason, S., Anderson, S., Sly, P., Samnick, K., Chan, H. (2015). An Apparatus to Deliver Mannitol Powder for Bronchial Provocation in Children Under Six Years Old. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28(6), 452-461. [More Information]
Flynn, S., Tong, Z., Yang, R., Kamiya, H., Yu, A., Chan, H. (2015). Computational fluid dynamics (CFD) investigation of the gas-solid flow and performance of Andersen cascade impactor. Powder Technology, 285, 128-137. [More Information]
Leung, S., Tang, P., Zhou, Q., Tong, Z., Leung, C., Decharaksa, J., Yang, R., Chan, H. (2015). De-agglomeration Effect of the US Pharmacopeia and Alberta Throats on Carrier-Based Powders in Commercial Inhalation Products. The AAPS Journal, 17(6), 1407-1416. [More Information]
Tong, Z., Yu, A., Chan, H., Yang, R. (2015). Discrete Modelling of Powder Dispersion in Dry Powder Inhalers - A Brief Review. Current Pharmaceutical Design, 21(27), 3966-3973. [More Information]
Chan, H., Zhou, Q. (2015). Editorial - Emerging Formulation Design and Drug Delivery Systems for Inhaled Therapy. Current Pharmaceutical Design, 21(27), 3852-3853. [More Information]
Wong, J., Kwok, P., Chan, H. (2015). Electrostatics in pharmaceutical solids. Chemical Engineering Science, 125, 225-237. [More Information]
Kim, S., Naskar, D., Kundu, S., Bishop, D., Doble, P., Boddy, A., Chan, H., Wall, I., Chrzanowski, W. (2015). Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer. Scientific Reports, 5, 1-13. [More Information]
Liang, W., Chow, M., Lau, P., Zhou, Q., Kwok, P., Leung, G., Mason, A., Chan, H., Poon, L., Lam, J. (2015). Inhalable Dry Powder Formulations of siRNA and pH-Responsive Peptides with Antiviral Activity Against H1N1 Influenza Virus. Molecular Pharmaceutics, 12(3), 910-921. [More Information]
Velkov, T., Rahim, N., Zhou, Q., Chan, H., Li, J. (2015). Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead. Advanced Drug Delivery Reviews, 85, 65-82. [More Information]
Chan, H., Li, J. (2015). Inhaled antimicrobial chemotherapy for respiratory tract infections: successes, challenges and the road ahead. Advanced Drug Delivery Reviews, 85, v-vii. [More Information]
Zhou, Q., Leung, S., Tang, P., Parumasivam, T., Loh, Z., Chan, H. (2015). Inhaled formulations and pulmonary drug delivery systems for respiratory infections. Advanced Drug Delivery Reviews, 85, 83-89. [More Information]
D'Sa, D., Lechuga-Ballesteros, D., Chan, H. (2015). Isothermal Microcalorimetry of Pressurized Systems II: Effect of Excipient and Water Ingress on Formulation Stability of Amorphous Glycopyrrolate. Pharmaceutical Research, 32(2), 714-722. [More Information]
Wong, J., Lin, Y., Kwok, P., Niemela, V., Crapper, J., Chan, H. (2015). Measuring Bipolar Charge and Mass Distributions of Powder Aerosols by a Novel Tool (BOLAR). Molecular Pharmaceutics, 12(9), 3433-3440. [More Information]
Young, P., Salama, R., Zhu, B., Phillips, G., Crapper, J., Chan, H., Traini, D. (2015). Multi-breath dry powder inhaler for delivery of cohesive powders in the treatment of bronchiectasis. Drug Development and Industrial Pharmacy, 41(5), 859-865. [More Information]
Tong, Z., Kamiya, H., Yu, A., Chan, H., Yang, R. (2015). Multi-Scale Modelling of Powder Dispersion in a Carrier-Based Inhalation System. Pharmaceutical Research, 32(6), 2086-2096. [More Information]
Chan, J., Tyne, A., Pang, A., McLachlan, A., Perera, V., Chan, J., Britton, W., Chan, H., Duke, C., Young, P., Traini, D. (2015). Murine pharmacokinetics of rifapentine delivered as an inhalable dry powder. International Journal of Antimicrobial Agents, 45(3), 319-323. [More Information]
Zhou, Q., Sun, S., Chan, J., Wang, P., Barraud, N., Rice, S., Wang, J., Li, J., Chan, H. (2015). Novel Inhaled Combination Powder Containing Amorphous Colistin and Crystalline Rifapentine with Enhanced Antimicrobial Activities against Planktonic Cells and Biofilm of Pseudomonas aeruginosa for Respiratory Infections. Molecular Pharmaceutics, 12(8), 2594-2603. [More Information]
Lin, Y., Wong, J., Qu, L., Chan, H., Zhou, Q. (2015). Powder Production and Particle Engineering for Dry Powder Inhaler Formulations. Current Pharmaceutical Design, 21(27), 3902-3916. [More Information]
Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2015). The Effect of Active Pharmaceutical Ingredients on Aerosol Electrostatic Charges from Pressurized Metered Dose Inhalers. Pharmaceutical Research, 32, 2928-2936. [More Information]
Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2015). The effect of actuator nozzle designs on the electrostatic charge generated in pressurised metered dose inhaler aerosols. Pharmaceutical Research, 32(4), 1237-1248. [More Information]
Kim, S., Wong, A., Neel, E., Chrzanowski, W., Chan, H. (2015). The future perspectives of natural materials for pulmonary drug delivery and lung tissue engineering. Expert Opinion on Drug Delivery, 12(6), 869-887. [More Information]
Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
Chan, J., Wong, J., Zhou, Q., Leung, S., Chan, H. (2014). Advances in Device and Formulation Technologies for Pulmonary Drug Delivery. AAPS PharmSciTech, 15(4), 882-897. [More Information]
Cipolla, D., Wu, H., Gonda, I., Chan, H. (2014). Aerosol Performance and Long-Term Stability of Surfactant-Associated Liposomal Ciprofloxacin Formulations with Modified Encapsulation and Release Properties. AAPS PharmSciTech, 15(5), 1218-1227. [More Information]
Chan, J., Wong, J., Chan, H., Traini, D. (2014). An overview of biosimilars. Journal and Proceedings of the Royal Society of New South Wales, 147(451 and 452), 77-83.
D'Sa, D., Chan, H., Chrzanowski, W. (2014). Attachment of micro- and nano-particles on tipless cantilevers for colloidal probe microscopy. Journal of Colloid and Interface Science, 426, 190-198. [More Information]
Kwok, P., Chan, H. (2014). Delivery of inhalation drugs to children for asthma and other respiratory diseases. Advanced Drug Delivery Reviews, 73, 83-88. [More Information]
Cipolla, D., Wu, H., Eastman, S., Redelmeier, T., Gonda, I., Chan, H. (2014). Development and Characterization of an In Vitro Release Assay for Liposomal Ciprofloxacin for Inhalation. Journal of Pharmaceutical Sciences, 103(1), 314-327. [More Information]
Wong, J., Kwok, P., Noakes, T., Fathi, A., Dehghani, F., Chan, H. (2014). Effect of crystallinity on electrostatic charging in dry powder inhaler formulations. Pharmaceutical Research, 31(7), 1656-1664. [More Information]
Zhou, Q., Tang, P., Leung, S., Chan, J., Chan, H. (2014). Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced Drug Delivery Reviews, 75, 3-17. [More Information]
Liang, W., Kwok, P., Chow, M., Tang, P., Mason, A., Chan, H., Lam, J. (2014). Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 64-73. [More Information]
Ung, K., Rao, N., Weers, J., Clark, A., Chan, H. (2014). In vitro assessment of dose delivery performance of dry powders for inhalation. Aerosol Science and Technology, 48(10), 1099-1110. [More Information]
D'Sa, D., Lechuga-Ballesteros, D., Chan, H. (2014). Isothermal Microcalorimetry of Pressurized Systems I: A Rapid Method to Evaluate Pressurized Metered Dose Inhaler Formulations. Pharmaceutical Research, 31(10), 2716-2723. [More Information]
Cipolla, D., Wu, H., Gonda, I., Eastman, S., Redelmeier, T., Chan, H. (2014). Modifying the release properties of liposomes toward personalized medicine. Journal of Pharmaceutical Sciences, 103(6), 1851-1862. [More Information]
Onoue, S., Yamada, S., Chan, H. (2014). Nanodrugs: pharmacokinetics and safety. International Journal of Nanomedicine, 9(1), 1025-1037. [More Information]
Kwok, P., Chan, H. (2014). Nanotechnology Versus other Techniques in Improving Drug Dissolution. Current Pharmaceutical Design, 20(3), 474-482. [More Information]
Wong, J., D'Sa, D., Foley, M., Chan, J., Chan, H. (2014). NanoXCT: A Novel Technique to Probe the Internal Architecture of Pharmaceutical Particles. Pharmaceutical Research, 31(11), 3085-3094. [More Information]
Young, P., Crapper, J., Gary, P., Sharma, K., Chan, H., Traini, D. (2014). Overcoming Dose Limitations Using the Orbital® Multi-Breath Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2), 138-147. [More Information]
Dexter, D., Chan, H., Chrzanowski, W. (2014). Predicting Physical Stability in Pressurized Metered Dose Inhalers via Dwell and Instantaneous Force Colloidal Probe Microscopy. European Journal of Pharmaceutics and Biopharmaceutics, 88(1), 129-135. [More Information]
Yang, M., Chan, J., Chan, H. (2014). Pulmonary drug delivery by powder aerosols. Journal of Controlled Release, 193, 228-240. [More Information]
Dexter, D., Chan, H., Kim, H., Chrzanowski, W. (2014). Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy. Journal of Visualized Experiments, 89, 1-9. [More Information]
Lee, S., Teo, J., Heng, D., Zhao, Y., Ng, W., Chan, H., Tan, R. (2014). Steroid-decorated antibiotic microparticles for inhaled anti-infective therapy. Journal of Pharmaceutical Sciences, 103(4), 1115-1125. [More Information]
Zhou, Q., Gegenbach, T., Denman, J., Yu, H., Li, J., Chan, H. (2014). Synergistic Antibiotic Combination Powders of Colistin and Rifampicin Provide High Aerosolization Efficiency and Moisture Protection. The AAPS Journal, 16(1), 37-47. [More Information]
Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2014). The Influence of Actuator Materials and Nozzle Designs on Electrostatic Charge of Pressurised Metered Dose Inhaler (pMDI) Formulations. Pharmaceutical Research, 31(5), 1325-1337. [More Information]
Chan, J., Chan, H., Prestidge, C., Denman, J., Young, P., Traini, D. (2013). A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 285-292. [More Information]
D'Addio, S., Chan, J., Kwok, P., Benson, B., Prud'homme, R., Chan, H. (2013). Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying. Pharmaceutical Research, 30(11), 2891-2901. [More Information]
Tong, Z., Zheng, B., Yang, R., Yu, A., Chan, H. (2013). CFD-DEM investigation of the dispersion mechanisms in commercial dry powder inhalers. Powder Technology, 240, 19-24. [More Information]
Zhou, Q., Morton, D., Yu, H., Jacob, J., Wang, J., Li, J., Chan, H. (2013). Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro Evaluation. Journal of Pharmaceutical Sciences, 102(10), 3736-3747. [More Information]
Zhou, Q., Tong, Z., Tang, P., Citterio, M., Yang, R., Chan, H. (2013). Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler - A Case Study on Aerolizer® Foradile®. The AAPS Journal, 15(2), 511-522. [More Information]
Adi, S., Adi, H., Chan, H., Tong, Z., Yang, R., Yu, A. (2013). Effects of mechanical impaction on aerosol performance of particles with different surface roughness. Powder Technology, 236, 164-170. [More Information]
Wong, J., Chan, H., Kwok, P. (2013). Electrostatics in pharmaceutical aerosols for inhalation. Therapeutic Delivery, 4(8), 981-1002. [More Information]
Kwek, J., Heng, D., Lee, S., Ng, W., Chan, H., Adi, S., Heng, J., Tan, R. (2013). High speed imaging with electrostatic charge monitoring to track powder deagglomeration upon impact. Journal of Aerosol Science, 65, 77-87. [More Information]
Cipolla, D., Chan, H. (2013). Inhaled antibiotics to treat lung infection. Pharmaceutical Patent Analyst, 2(5), 647-663. [More Information]
Cipolla, D., Gonda, I., Chan, H. (2013). Liposomal formulations for inhalation. Therapeutic Delivery, 4(8), 1047-1072. [More Information]
Heng, D., Lee, S., Ng, W., Chan, H., Kwek, J., Tan, R. (2013). Novel alternatives to reduce powder retention in the dry powder inhaler during aerosolization. International Journal of Pharmaceutics, 452(1-2), 194-200. [More Information]
Kwok, P., Chan, H. (2013). Pulmonary drug delivery. Therapeutic Delivery, 4(8), 877-878. [More Information]
Guastella, A., Hickie, I., McGuinness, M., Otis, M., Woods, E., Disinger, H., Chan, H., Chen, T., Banati, R. (2013). Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology, 38(5), 612-625. [More Information]
Lee, S., Teo, J., Heng, D., Ng, W., Chan, H., Tan, R. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 275-284. [More Information]
Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug Development and Industrial Pharmacy, 39(11), 1625-1637. [More Information]
Syed Muhammad, S., Oubani, H., Abbas, A., Chan, H., Kwok, P., Dehghani, F. (2013). The production of dry powder by the sonocrystallisation for inhalation drug delivery. Powder Technology, 246, 337-344. [More Information]
Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]
Guastella, A., Alvares, G., Hickie, I., Chan, H., Chen, T., Banati, R. (2013). Unitary hormonal models, peripheral markers, and evaluation of response to drug: A response to Weisman and Feldman. Psychoneuroendocrinology, 38, 627-628. [More Information]
De Boer, A., Chan, H., Price, R. (2012). A critical view on lactose-based drug formulation and device studies for dry powder inhalation: Which are relevant and what interactions to expect? Advanced Drug Delivery Reviews, 64(3), 257-274. [More Information]
Heng, D., Lee, S., Kwek, J., Ng, W., Chan, H., Tan, R. (2012). Assessing the combinatorial influence of climate, formulation and device on powder aerosolization using the Taguchi experimental design. Powder Technology, 226, 253-260. [More Information]
D'Addio, S., Chan, J., Kwok, P., Prud'homme, R., Chan, H. (2012). Constant size, variable density aerosol particles by ultrasonic spray freeze drying. International Journal of Pharmaceutics, 427(2), 185-191. [More Information]
Chan, J., Traini, D., Chan, H., Young, P., Kwok, P. (2012). Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(5), 297-305. [More Information]
Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, H. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807. [More Information]
Lam, J., Liang, W., Chan, H. (2012). Pulmonary delivery of therapeutic siRNA. Advanced Drug Delivery Reviews, 64(1), 1-15. [More Information]
Fleming, J., Bailey, D., Chan, H., Conway, J., Kuehl, P., Laube, B., Newman, S. (2012). Standardization of Techniques for Using Single-Photon Emission Computed Tomography (SPECT) for Aerosol Deposition Assessment of Orally Inhaled Products. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(Supplement 1), S-29-S-51. [More Information]
Handayani, D., Meyer, B., Chen, J., Tang, P., Kwok, P., Chan, H., Huang, X. (2012). The comparison of the effect of oat and Shiitake mushroom powder to prevent body weight gain in rats fed high fat diet. Food and Nutrition Sciences, 3(7), 1009-1019. [More Information]
Syed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance. The Journal of Supercritical Fluids, 71, 92-101. [More Information]
Wong, W., Fletcher, D., Traini, D., Chan, H., Young, P. (2012). The use of computational approaches in inhaler development. Advanced Drug Delivery Reviews, 64(4), 312-322. [More Information]
Devadason, S., Chan, H., Haeussermann, S., Kietzig, C., Kuehl, P., Newman, S., Sommerer, K., Taylor, G. (2012). Validation of radiolabeling of drug formulations for aerosol deposition assessment of orally inhaled products. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(Supplement 1), S-6-S-9. [More Information]
Adi, S., Adi, H., Chan, H., Finlay, W., Tong, Z., Yang, R., Yu, A. (2011). Agglomerate strength and dispersion of pharmaceutical powders. Journal of Aerosol Science, 42(4), 285-294. [More Information]
Yamasaki, K., Kwok, P., Fukushige, K., Prud'homme, R., Chan, H. (2011). Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former. International Journal of Pharmaceutics, 420(1), 34-42. [More Information]
Zhang, J., Wu, L., Chan, H., Watanabe, W. (2011). Formation, characterization, and fate of inhaled drug nanoparticles. Advanced Drug Delivery Reviews, 63(6), 441-455. [More Information]
Rojanarat, W., Changsan, N., Tawithong, E., Pinsuwan, S., Chan, H., Srichana, T. (2011). Isoniazid proliposome powders for inhalation-preparation, characterization and cell culture studies. International Journal of Molecular Sciences, 12(7), 4414-4434. [More Information]
Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
Tang, P., Chan, H., Rajbhandari, D., Phipps, P. (2011). Method to Introduce Mannitol Powder to Intubated Patients to Improve Sputum Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24(1), 1-9. [More Information]
Lee, S., Heng, D., Ng, W., Chan, H., Tan, R. (2011). Nano Spray Drying: A Novel Method for Preparing Protein Nanoparticles for Protein Therapy. International Journal of Pharmaceutics, 403(1-2), 192-200. [More Information]
Tong, Z., Adi, S., Yang, R., Chan, H., Yu, A. (2011). Numerical investigation of the de-agglomeration mechanisms of fine powders on mechanical impaction. Journal of Aerosol Science, 42, 811-819. [More Information]
Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-Up in Dry Powder Inhalers: Evaluation and Modelling of Impaction Effects for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(7), 2744-2754. [More Information]
Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-up in Dry Powder Inhalers: Evaluation and Modelling of the Influence of Grid Structures for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(11), 4710-4721. [More Information]
Chan, H., Kwok, P. (2011). Production methods for nanodrug particles using the bottom-up approach. Advanced Drug Delivery Reviews, 63(6), 406-416. [More Information]
Syed Muhammad, S., Langrish, T., Tang, P., Adi, H., Chan, H., Kazarian, S., Dehghani, F. (2010). A novel method for the production of crystalline micronised particles. International Journal of Pharmaceutics, 388(1-2), 114-122. [More Information]
Kumon, M., Kwok, P., Adi, H., Heng, D., Chan, H. (2010). Can low-dose combination products for inhalation be formulated in single crystalline particles? European Journal of Pharmaceutical Sciences, 40(1), 16-24. [More Information]
Adi, H., Young, P., Chan, H., Agus, H., Traini, D. (2010). Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European Journal of Pharmaceutical Sciences, 40, 239-247. [More Information]
Adi, H., Young, P., Chan, H., Salama, R., Traini, D. (2010). Controlled release antibiotics for dry powder lung delivery. Drug Development and Industrial Pharmacy, 36(1), 119-126. [More Information]
Kwok, P., Trietsch, S., Kumon, M., Chan, H. (2010). Electrostatic Charge Characteristics of Jet Nebulized Aerosols. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(3), 149-159. [More Information]
Kwok, P., Tunsirikongkon, A., Glover, W., Chan, H. (2010). Formation of Protein Nano-Matrix Particles with Controlled Surface Architecture for Respiratory Drug Delivery. Pharmaceutical Research, 28(4), 788-796. [More Information]
Adi, S., Tong, Z., Chan, H., Yang, R., Yu, A. (2010). Impact angles as an alternative way to improve aerosolisation of powders for inhalation? European Journal of Pharmaceutical Sciences, 41(2), 320-327. [More Information]
Tong, Z., Yang, R., Chu, K., Yu, A., Adi, S., Chan, H. (2010). Numerical study of the effects of particle size and polydispersity on the agglomerate dispersion in a cyclonic flow. Chemical Engineering Journal, 164, 432-441. [More Information]
Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2010). Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems. Pharmaceutical Research, 27(7), 1367-1376. [More Information]
Cipolla, D., Chan, H., Schuster, J., Farina, D. (2010). Personalizing aerosol medicine: development of delivery systems tailored to the individual. Therapeutic Delivery, 1(5), 667-682. [More Information]
Wong, W., Crapper, J., Chan, H., Traini, D., Young, P. (2010). Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of Pharmaceutical and Biomedical Analysis, 51(4), 853-857. [More Information]
Weers, J., Bell, J., Chan, H., Cipolla, D., Dunbar, C., Hickey, A., Smith, I. (2010). Pulmonary Formulations: What Remains to be Done? Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(2), S5-S23. [More Information]
Hoe, S., Traini, D., Chan, H., Young, P. (2010). The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems. Pharmaceutical Research, 27(7), 1325-1336. [More Information]
Tang, P., Chan, H., Chiou, H., Ogawa, K., Jones, M., Adi, H., Buckton, G., Prud'homme, R., Raper, J. (2009). Characterisation and aerosolisation of mannitol particles produced via confined liquid impinging jets. International Journal of Pharmaceutics, 367, 51-57. [More Information]
Salama, R., Ladd, L., Chan, H., Traini, D., Young, P. (2009). Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. The AAPS Journal, 11(3), 465-468. [More Information]
Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
Kwok, P., Chan, H. (2009). Electrostatics of pharmaceutical inhalation aerosols. Journal of Pharmacy and Pharmacology, 61(12), 1587-1599. [More Information]
Hoe, S., Young, P., Chan, H., Traini, D. (2009). Introduction of the Electrical Next Generation Impactor (eNGI) and Investigation of its Capabilities for the Study of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 26(2), 431-437. [More Information]
Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
Hoe, S., Traini, D., Chan, H., Young, P. (2009). Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences, 38, 88-94. [More Information]
Tong, Z., Yang, R., Yu, A., Adi, S., Chan, H. (2009). Numerical modelling of the breakage of loose agglomerates of fine particles. Powder Technology, 196(2), 213-221. [More Information]
Changsan, N., Chan, H., Separovic, F., Srichana, T. (2009). Physicochemical Characterization and Stability of Rifampicin Liposome Dry Powder Formulations for Inhalation. Journal of Pharmaceutical Sciences, 98(2), 628-639. [More Information]
Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
Heng, D., Ogawa, K., Cutler, D., Chan, H., Raper, J., Ye, L., Yun, J. (2009). Pure drug nanoparticles in tablets: what are the dissolution limitations? Journal of Nanoparticle Research, 12(5), 1743-1754. [More Information]
Salama, R., Traini, D., Chan, H., Young, P. (2009). Recent Advances in Controlled Release Pulmonary Therapy. Current Drug Delivery, 6(4), 404-414. [More Information]
Hoe, S., Traini, D., Chan, H., Young, P. (2009). The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers. Pharmaceutical Research, 26(12), 2639-2646. [More Information]
Tang, P., Chan, H., Raper, J. (2009). Validation of computation method to predict aerodynamic diameter of particles with rough surface. Powder Technology, 192(1), 74-84. [More Information]
Chiou, H., Chan, H., Heng, D., Prud'homme, R., Raper, J. (2008). A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation. Journal of Aerosol Science, 39(6), 500-509. [More Information]
Yang, R., Yu, A., Choi, S., Coates, M., Chan, H. (2008). Agglomeration of fine particles subjected to centripetal compaction. Powder Technology, 184(1), 122-129. [More Information]
Young, P., Roberts, D., Chiou, H., Rae, W., Chan, H., Traini, D. (2008). Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science, 39, 82-93. [More Information]
Heng, D., Cutler, D., Chan, H., Yun, J., Raper, J. (2008). Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model. Langmuir, 24(14), 7538-7544. [More Information]
Kwok, P., Noakes, T., Chan, H. (2008). Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 39(3), 211-226. [More Information]
Glover, W., Chan, H., Eberl, S., Daviskas, E., Verschuer, J. (2008). Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers. International Journal of Pharmaceutics, 349(1/2), 314-322. [More Information]
Kwok, P., Chan, H. (2008). Effect of Relative Humidity on the Electrostatic Charge Properties of Dry Powder Inhaler Aerosols. Pharmaceutical Research, 25(2), 277-288. [More Information]
Chiou, H., Chan, H., Prud'homme, R., Raper, J. (2008). Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles. Drug Development and Industrial Pharmacy, 34(1), 59-64. [More Information]
Newman, S., Chan, H. (2008). In vitro/in vivo comparisons in pulmonary drug delivery. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 21(1), 77-84. [More Information]
Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information]
Salama, R., Hoe, S., Chan, H., Traini, D., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 486-495. [More Information]
Salama, R., Traini, D., Chan, H., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 145-152. [More Information]
Hu, T., Chiou, H., Chan, H., Chen, J., Yun, J. (2008). Preparation of inhalable salbutamol sulphate using reactive high gravity controlled precipitation. Journal of Pharmaceutical Sciences, 97(2), 944-949. [More Information]
Adi, S., Adi, H., Chan, H., Young, P., Traini, D., Yang, R., Yu, A. (2008). Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir, 24(19), 11307-11312. [More Information]
Tang, P., Fletcher, D., Chan, H., Raper, J. (2008). Simple and cost-effective powder disperser for aerosol particle size measurement. Powder Technology, 187(1), 27-36. [More Information]
Heng, D., Cutler, D., Chan, H., Yun, J., Raper, J. (2008). What is a suitable dissolution method for drug nanoparticles? Pharmaceutical Research, 25(7), 1696-1701. [More Information]
Chan, H. (2008). What is the role of particle morphology in pharmaceutical powder aerosols? Expert Opinion on Drug Delivery, 5(8), 909-914. [More Information]
Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2007). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, online(DOI 10.1002/jps.21239), 1-11. [More Information]
Chan, H., Young, P., Traini, D., Coates, M. (2007). Dry powder inhalers: challenges and goals for next generation therapies. Pharmaceutical Technology Europe, 19(4), 19-24.
Heng, D., Tang, P., Cairney, J., Chan, H., Cutler, D., Salama, R., Yun, J. (2007). Focused-ion-beam Milling: A Novel Approach to Probing the Interior of Particles Used for Inhalation Aerosols. Pharmaceutical Research, 24(9), 1608-1617. [More Information]
Mitchell, J., Newman, S., Chan, H. (2007). In Vitro and In Vivo Aspects of Cascade Impactor Tests and Inhaler Performance: A Review. AAPS PharmSciTech, 8(4), 110-E1-110-E12.
Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
Coates, M., Chan, H., Fletcher, D., Chiou, H. (2007). Influence of Mouthpiece Geometry on the Aerosol Delivery Performance of a Dry Powder Inhaler. Pharmaceutical Research, 24(8), 1450-1456. [More Information]
Chiou, H., Li, L., Hu, T., Chan, H., Chen, J., Yun, J. (2007). Production of salbutamol sulfate for inhalation by high-gravity controlled antisolvent precipitation. International Journal of Pharmaceutics, 331(1), 93-98. [More Information]
Young, P., Traini, D., Coates, M., Chan, H. (2007). Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, 394(2), 315-319. [More Information]
Jouyban, A., Soltanpour, S., Soltani, S., Chan, H., Acree, W. (2007). Solubility prediction of drugs in water-cosolvent mixtures using Abraham solvation parameters. Journal of Pharmacy and Pharmaceutical Sciences, 10(3), 263-277. [More Information]
Abbas, A., Srour, M., Tang, P., Chiou, H., Chan, H., Romagnoli, J. (2007). Sonocrystallization of sodium chloride particles for inhalation. Chemical Engineering Science, 62(9), 2445-2453. [More Information]
Adi, H., Traini, D., Chan, H., Young, P. (2007). The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Sciences, Published online DOI 10.1002/jps.21195(Print version 2008 VOL. 97, NO. 7), 2780-2788. [More Information]
Young, P., Chan, H., Chiou, H., Edge, S., Tee, H., Traini, D. (2007). The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of Pharmaceutical Sciences, 96(5), 1331-1341. [More Information]
Young, P., Chiou, H., Tee, H., Traini, D., Chan, H., Thielmann, F., Burnett, D. (2007). The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, 33(1), 91-97. [More Information]
Chan, H. (2006). Dry powder aerosol delivery systems: current and future research directions. Journal of Aerosol Medicine, 19(1), 21-27. [More Information]
Chan, H. (2006). Dry powder aerosol drug delivery-Opportunities for colloid and surface scientists. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 284-285, 50-55. [More Information]
Coates, M., Chan, H., Fletcher, D., Raper, J. (2006). Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. Journal of Pharmaceutical Sciences, 95(6), 1382-1392. [More Information]
Kwok, P., Collins, R., Chan, H. (2006). Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 37(12), 1671-1682. [More Information]
Glover, W., Chan, H., Eberl, S., Daviskas, E., Anderson, S. (2006). Lung Deposition of Mannitol Powder Aerosol in Healthy Subjects. Journal of Aerosol Medicine, 19(4), 522-532. [More Information]
Jouyban, A., Khoubnasabjafari, M., Chan, H., Acree, W. (2006). Mathematical representation of solubility of amino acids in binary aqueous-organic solvent mixtures at various temperatures using the Jouyban-Acree model. Die Pharmazie: an international journal of pharmaceutical sciences, 61(9), 789-792.
Tang, P., Chan, H., Tam, E., de Gruyter, N., Chan, J. (2006). Preparation of NaCl powder suitable for inhalation. Industrial and Engineering Chemistry Research, 45(12), 4188-4192. [More Information]
Jouyban, A., Chan, H., Chew, N., Khoubnasabjafari, M., Acree, W. (2006). Solubility Prediction of Paracetamol in Binary and Ternary Solvent Mixtures Using Jouyban-Acree Model. Chemical and Pharmaceutical Bulletin, 54(4), 428-431. [More Information]
Jouyban, G., Chew, N., Chan, H., Khoubnasabjafari, M., Acree, W. (2006). Solubility prediction of salicylic acid in water-ethanol-propylene glycol mixtures using the Jouyban-Acree model. Die Pharmazie: an international journal of pharmaceutical sciences, 61(4), 318-321. [More Information]
Eberl, S., Chan, H., Daviskas, E. (2006). SPECT Imaging for Radioaerosol Deposition and Clearance Studies. Journal of Aerosol Medicine, 19(1), 8-20. [More Information]
Issa, F., Kassiou, M., Chan, H., McLeod, M. (2006). Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition. Australian Journal of Chemistry, 59(1), 53-58. [More Information]
Chan, H., Chiou, H., Kwok, P. (2006). The 15th International Society of Aerosols in Medicine Congress. Perth, Australia, 14-18 March 2005. Expert Opinion on Drug Delivery, 3(1), 163-167. [More Information]
Jouyban, A., Chew, N., Chan, H., Sabour, M., Acree, W. (2005). A Unified Cosolvency Model for Calculating Solute Solubility in Mixed Solvents. Chemical and Pharmaceutical Bulletin, 53(6), 634-637. [More Information]
Koskela, H., Martens, R., Brannan, J., Anderson, S., Leuppi, J., Chan, H. (2005). Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. Respirology, 10, 442-448. [More Information]
Chew, N., Shekunov, B., Tong, H., Chow, A., Savage, C., Wu, J., Chan, H. (2005). Effect of amino acids on the dispersion of disodium cromoglycate powders. Journal of Pharmaceutical Sciences, 94(10), 2289-2300. [More Information]
Kwok, P., Glover, W., Chan, H. (2005). Electrostatic charge characteristics of aerosols produced from metered dose inhalers. Journal of Pharmaceutical Sciences, 94(12), 2789-2799. [More Information]
Chew, N., Tang, P., Chan, H., Raper, J. (2005). How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharmaceutical Research, 22(1), 148-152. [More Information]
Coates, M., Chan, H., Fletcher, D., Raper, J. (2005). Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research, 22(9), 1445-1453. [More Information]
Daviskas, E., Anderson, S., Gomes, K., Briffa, P., Cochrane, B., Chan, H., Young, I., Rubin, B. (2005). Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputum. Respirology, 10(1), 46-56. [More Information]
Jouyban, A., Soltani, S., Chan, H., Acree, W. (2005). Modeling acid dissociation constant of analytes in binary solvents at various temperatures using Jouyban-Acree model. Thermochimica acta, 428, 119-123. [More Information]
Jouyban, A., Khoubnasabjafari, M., Chan, H. (2005). Modeling the entrainer effects on solubility of solutes in supercritical carbon dioxide. Chemical and Pharmaceutical Bulletin, 53(3), 290-295. [More Information]
Leuppi, J., Tandjung, R., Anderson, S., Stolz, D., Brutsche, M., Bingisser, R., Perruchoud, A., Surber, C., Knoblauch, A., Andersson, M., Chan, H., et al (2005). Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept. Pulmonary Pharmacology and Therapeutics, 18(2), 83-88. [More Information]
Coates, M., Fletcher, D., Chan, H., Raper, J. (2005). The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research, 22(6), 923-932. [More Information]
Jouyban, A., Soltanpour, S., Chan, H. (2004). A Simple Relationship Between Dielectric Constant Of Mixed Solvents With Solvent Composition And Temperature. International Journal of Pharmaceutics, 269(2), 353-360. [More Information]
Koskela, H., Hyvarinen, L., Brannan, J., Chan, H., Anderson, S. (2004). Coughing During Mannitol Challenge Is Associated With Asthma. Chest, 125(6), 1985-1992. [More Information]
Coates, M., Fletcher, D., Chan, H., Raper, J. (2004). Effect Of Design On The Performance Of A Dry Powder Inhaler Using Computational Fluid Dynamics. Part 1: Grid Structure And Mouthpiece Length. Journal of Pharmaceutical Sciences, 93(11), 2863-2876. [More Information]
Chew, N., Reddel, H., Bosnic-Anticevich, S., Chan, H. (2004). Effect Of Mouthpiece Washing On Aerosol Performance Of Cfc-Free Ventolin. Journal of Asthma, 41(7), 721-727. [More Information]
Glover, W., Chan, H. (2004). Electrostatic Charge Characterization Of Pharmaceutical Aerosols Using Electrical Low-Pressure Impaction (Elpi). Journal of Aerosol Science, 35(6), 755-764. [More Information]
Chen, J., Zhou, M., Shao, L., Wang, Y., Yun, J., Chew, N., Chan, H. (2004). Feasibility Of Preparing Nanodrugs By High-Gravity Reactive Precipitation. International Journal of Pharmaceutics, 269(1), 267-274. [More Information]
Chan, H., Clark, A., Feeley, J., Kuo, M., Lehrman, S., Pikal-Cleland, K., Miller, D., Vehring, R., Lechuga-Ballesteros, D. (2004). Physical Stability Of Salmon Calcitonin Spray-Dried Powders For Inhalation. Journal of Pharmaceutical Sciences, 93(3), 792-804. [More Information]
Tang, P., Chan, H., Raper, J. (2004). Prediction Of Aerodynamic Diameter Of Particles With Rough Surfaces. Powder Technology, 147(1-3), 64-78. [More Information]
Jouyban, G., Chan, H., Romero, S., Khoubnasabjafari, M., Bustamante, P. (2004). Solubility prediction in water-ethanol mixtures based on the excess free energy approach using a minimum number of experimental data. Die Pharmazie: an international journal of pharmaceutical sciences, 59(2), 117-120.
Jouyban, A., Jabbaribar, F., Chan, H. (2003). An improved empirical model to calculate solute solubility in supercritical carbon dioxide. Die Pharmazie: an international journal of pharmaceutical sciences, 58(6), 396-398.
Jouyban, A., Chan, H., Khoubnasabjafari, M., Clark, B. (2003). Calculation of electrophoretic mobility in ternary solvent electrolyte systems. Journal of Pharmaceutical and Biomedical Analysis, 32(2), 203-208. [More Information]
Jouyban, A., Chan, H., Clark, B., Kenndler, E. (2003). Comparison of different algorithms to calculate electrophoretic mobility of analytes as a function of binary solvent composition. Electrophoresis, 24(10), 1596-1602. [More Information]
Bustami, R., Chan, H., Sweeney, T., Dehghani, F., Foster, N. (2003). Generation of Fine Powders of Recombinant Human Deoxyribonuclease Using the Aerosol Solvent Extraction System. Pharmaceutical Research, 20(12), 2028-2035. [More Information]
Koskela, H., Taivainen, A., Tukiainen, H., Chan, H. (2003). Inhalation Challenge with Bovine Dander Allergens: Who Needs It? Chest, 124(1), 383-391. [More Information]
Chan, H. (2003). Inhalation drug delivery devices and emerging technologies. Expert Opinion on Therapeutic Patents, 13(9), 1333-1343. [More Information]
Tang, P., Chew, N., Chan, H., Raper, J. (2003). Limitation of Determination of Surface Fractal Dimension Using N2 Adsorption Isotherms and Modified Frenkel-Halsey-Hill Theory. Langmuir, 19(7), 2632-2638. [More Information]
Holzer, K., Anderson, S., Chan, H., Douglass, J. (2003). Mannitol as a Challenge Test to Identify Exercise-induced Bronchoconstriction in Elite Athletes. American Journal of Respiratory and Critical Care Medicine, 167(4), 534-537. [More Information]
Jouyban, A., Grosse, S., Chan, H., Coleman, M., Clark, B. (2003). Mathematical representation of electrophoretic mobility of basic drugs in ternary solvent buffers in capillary zone electrophoresis. Journal of Chromatography A, 994(1-2), 191-198. [More Information]
Chan, H., Chew, N. (2003). Novel alternative methods for the delivery of drugs for the treatment of asthma. Advanced Drug Delivery Reviews, 55(7), 793-805. [More Information]
Jouyban, A., Khoubnasabjafari, M., Chan, H., Altria, K., Clark, B. (2003). Predicting Electrophoretic Mobility of Beta-blockers in a Water-Methanol Based Electrolyte System. Chromatographia, 57(3-4), 191-195. [More Information]
Koskela, H., Hyraerinen, L., Brannan, J., Chan, H., Anderson, S. (2003). Responsiveness to Three Bronchial Provocation Tests in Patients with Asthma. Chest, 124(6), 2171-2177. [More Information]
Koskela, H., Hyraerinen, L., Brannan, J., Chan, H., Anderson, S. (2003). Sensitivity and Validity of Three Bronchial Provocation Tests to Demonstrate the Effect of Inhaled Corticosteroids in Asthma. Chest, 124(4), 1341-1349. [More Information]
Jouyban, A., Romero, S., Chan, H., Clark, B., Bustamante, P. (2002). A cosolvency model to predict solubility of drugs at several temperatures from a limited number of solubility measurements. Chemical and Pharmaceutical Bulletin, 50(5), 594-599. [More Information]
Jouyban, A., Chan, H., Barzegar-Jalali, M., Acree, W. (2002). A model to represent solvent effects on the chemical stability of solutes in mixed solvent systems. International Journal of Pharmaceutics, 243(1-2), 167-172. [More Information]
Lam, Y., Bustami, R., Phan, T., Chan, H., Seoarivuc, F. (2002). A solid-state NMR study of protein mobility in lyophilized protein-sugar powders. Journal of Pharmaceutical Sciences, 91(4), 943-951. [More Information]
Goodall, S., Chew, N., Chan, H., Auriac, D., Waters, M. (2002). Aerosolization of protein solutions using thermal inkjet technology. Journal of Aerosol Medicine, 15(3), 351-357. [More Information]
Brennan, J., Koskela, H., Anderson, S., Chan, H. (2002). Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology, 7(1), 37-44. [More Information]
Jouyban, A., Grosse, S., Coleman, M., Chan, H., Kenndler, E., Clark, B. (2002). Calculation of electrophoretic mobility in mixed solvent buffers in capillary zone electrophoresis using a mixture response surface method. Analyst, 127(9), 1118-1192. [More Information]
Chan, H., Eberl, S., Daviskas, E., Constable, C., Young, I. (2002). Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study. Journal of Aerosol Medicine, 15(3), 307-311. [More Information]
Chew, N., Chan, H., Bagster, D., Mukharaiya, J. (2002). Characterization of pharmaceutical powder inhalers: estimation of energy input for powder dispersion and effect of capsule device configuration. Journal of Aerosol Science, 33(7), 999-1008. [More Information]
Chew, N., Chan, H. (2002). Effect of powder polydispersity on aerosol generation. Journal of Pharmacy and Pharmaceutical Sciences, 5(2), 162-168.
Daviskas, E., Anderson, S., Eberl, S., Chan, H., Young, I., Seale, J. (2002). Effects of terbutaline in combination with mannitol on mucociliary clearance. European Respiratory Journal, 20, 1423-1429. [More Information]
Jouyban, A., Chan, H., Clark, B., Acree, W. (2002). Mathematical representation of apparent dissociation constants in aqueous -organic solvent mixtures. International Journal of Pharmaceutics, 246(1-2), 135-142. [More Information]
Jouyban, A., Chan, H., Foster, N. (2002). Mathematical representation of solute solubility in supercritical carbon dioxide using empirical expressions. The Journal of Supercritical Fluids, 24(1), 19-35. [More Information]
Jouyban, A., Rehman, M., Shekunov, B., Chan, H., Clark, B., York, P. (2002). Solubility prediction in supercritical CO2 using minimum number of experiments. Journal of Pharmaceutical Sciences, 91(5), 1287-1295. [More Information]
Jouyban, G., Khoubnasabjafari, M., Chan, H., Clark, B., Acree, W. (2002). Solubility prediction of Anthracene in mixed solvents using a minimum number of experimental data. Chemical and Pharmaceutical Bulletin, 50(1), 21-25. [More Information]
Chew, N., Chan, H. (2002). The role of particle properties in pharmaceutical powder inhalation formulations. Journal of Aerosol Medicine, 15(3), 325-330. [More Information]
Anderson, S., Brannan, J., Chan, H. (2002). Use of aerosols for bronchila provocation testing in the laboratory: Where we have been and where we are going. Journal of Aerosol Medicine, 15(3), 313-324. [More Information]
Chan, H., Eberl, S., Daviskas, E., Constable, C., Young,, I. (2001). Aerosol deposition and clearance measurement: a novel technique using dynamic SPET. European Journal of Nuclear Medicine and Molecular Imaging, 28, 1365-1372.
Brannan, J., Chan, H., Seale, J., Anderson, S., Gomes,, K., King,, G. (2001). Fexofenadine decreases sensitivity to and Montelukast improves recovery from inhaled Mannitol. American Journal of Respiratory and Critical Care Medicine, 163(6), 1420-1425.
Chew, N., Chan, H. (2001). In vitro aerosol performance and dose uniformity between the Foradile aerolizer and the Oxis turbuhaler. Journal of Aerosol Medicine, 14(4), 495-501.
Chan, H., Hï¿½gman,, M., Lï¿½dvfksd=ttir,, D., Anderson, S., George, S., Hskansson,, L., MerilSinen, P., Hedenstrï¿½m,, H. (2001). Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects. Respiratory Physiology and Neurobiology, 124, 141-150. [More Information]
Leuppi, J., Salome, C., Brannan, J., Chan, H., Woolcock, A., Jenkins, C., Koskela, H., Anderson, S., Andersson, M. (2001). Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. European Respiratory Journal, 18, 444-450.
Jouyban, G., Chan, H., Clark, B., Kenndler, E. (2001). Mathematical representation of electrophoretic mobility in mixed aqueous-methanolic buffers in capillary zone electrophoresis. Journal of Separation Science, 13(8), 346-350. [More Information]
Chew, N., Chan, H. (2001). Pharmaceutical dry powder aerosol delivery. Kona, 19, 46-55. [More Information]
Leuppi, J., Salome, C., Xuan, W., Marks, G., Brannan, J., Chan, H., Woolcock, A., Jenkins, C., Anderson, S., Koskela,, H., et al (2001). Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. American Journal of Respiratory and Critical Care Medicine, 163(2), 406-412.
Jouyban, G., Dastmalchi, S., Chan, H., Hanaee, J., Javanmard, A., Barzegar-Jalali, M. (2001). Solubility prediction for Furosemide in water-cosolvent mixtures using the minimum number of experiments. Drug Development and Industrial Pharmacy, 27(6), 577-583.
Chan, H., Daviskas, E., Anderson, S., Eberl, S., Young,, I. (2001). The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis. Chest, 119(2), 414-421. [More Information]
Chew, N., Chan, H. (2001). Use of solid corrugated particles to enhance powder aerosol performance. Pharmaceutical Research, 18(11), 1570-1577. [More Information]

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Conferences

Kwok, P., Seungyeon, B., Ong, Y., Bhome, A., Tang, P., Chan, H. (2020). In vitro aerosol performance of originator and generic fixed dose combination metered dose inhalers. Respiratory Drug Delivery 2020, Digital: Respiratory Drug Delivery 2020.
Tai, W., Bhome, A., Tang, P., Chan, H., Kwok, P. (2020). In Vitro Aerosol Performance Of Originator And Indian Generic Fixed-dose Combination Dry Powder Inhalers. Respiratory Drug Delivery 2020, Digital: Respiratory Drug Delivery 2020.
Leung, S., Parumasivam, T., Gao, G., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Britton, W., Kutter, E., Chan, H. (2017). Production of inhalable bacteriophage dry powders. RDD Europe 2017 Respiratory Drug Delivery, Antibes, France: RDD Europe 2017 Respiratory Drug Delivery.
Le,, N., Yu, J., Phan,, H., Neild,, A., Chan, H., Alan,, T. (2016). Acoustic-enhanced 3D T junction for nanodrug crystallization. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, : Springer Verlag.
Chan, H., Tong, Z., Zhou, Q., Leung, C., Yu, A., Yang, R. (2016). Understanding the mechanics of powder dispersion in dry powder inhalers. RDD Asia 2016, Goa, India: Respiratory Drug Delivery Asia 2016.
Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Zhou, Q., Tong, Z., Tang, P., Yang, R., Chan, H. (2013). CFD analysis of the aerosolization of carrier-based dry powder inhaler formulations. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics. [More Information]
Wong, J., Kwok, P., Fathi, A., Dehghani, F., Chan, H. (2013). Crystallinity and electrostatic charge in inhalable salbutamol sulphate powder aerosols. Drug Delivery Australia, DDA 2013.
Wong, J., Kwok, P., Fathi, A., Dehghani, F., Chan, H. (2013). Effect of crystallinity on electrostatic charging in DPI formulations. 2013 Conference of Inhalation Asia, Hong Kong: Inhalation Asia.
Wong, J., Kwok, P., Fathi, A., Dehghani, F., Chan, H. (2013). Electrostatic properties of dry powder inhaler formulations: effect of crystallinity. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Liang, W., Kwok, P., Chow, M., Mason, A., Chan, H., Lam, J. (2013). Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Heng, D., Lee, S., Teo, J., Ng, W., Chan, H., Tan, R. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics. [More Information]
Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of glycerol on the formation and morphology of particles generated from budesonide solution-based pressurized metered dose inhalers. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Chen, Y., Traini, D., Fletcher, D., Chan, H., Lewis, D., Church, T., Young, P. (2013). The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Kwek, J., Heng, D., Lee, S., Ng, W., Chan, H., Heng, J., Tan, R. (2013). Visualizing powder de-agglomeration upon impact with simultaneous flowing charge behaviour. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics. [More Information]
Chan, J., Chan, H., Young, P., Traini, D. (2012). An Inhaled Triple Antibiotic Dry Powder Formulation for the Treatment of Tuberculosis. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
Faua'ad Sed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). Potential technique for the production of micronised lactose crystals by supercritical fluid conditioning. 10th International Symposium on Supercritical Fluids (ISSF) 2012, San Francisco, USA: Elsevier.
Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.
Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2010). Agglomerate Strength and Aerosol Performance of API-Only Powders. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2010). Does Impact Angle Affect Powder De-Agglomeration in a Model Throat? RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
Wong, W., Adi, H., Traini, D., Chan, H., Fletcher, D., Crapper, J., Young, P. (2010). Use of Rapid Prototyping and Computational Fluid Dynamics in the Design of DPI Devices. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
Syed Muhammad, S., Langrish, T., Chan, H., Tang, P., Dehghani, F. (2009). A new method for he production of crystalline microparticle. 9th International Symposium on Supercritical Fluids (ISSF) 2009, Arcachon, France.
Kwok, P., Glover, W., Chan, H. (2009). Aerosol Performance of Bovine Serum Albumin Nano-matrices for Inhalation. Asian Federation for Pharmaceutical Sciences (AFPS) 2009 Conference, Japan: Kumamoto University.
Hoe, S., Young, P., Chan, H., Traini, D. (2009). Application of the Electrical Next Generation Impactor (eNGI) for the Electrostatic Characterization of Commercial Dry Powder Inhaler Formulations. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
Wong, W., Traini, D., Chan, H., Crapper, J., Young, P. (2009). High Dose Respiratory Medicines: Pharmacopeia Methodologies for Determining Aerodynamic Mass Distributions. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
Heng, D., Ogawa, K., Cutler, D., Chan, H., Raper, J., Ye, L., Yun, J. (2009). Investigating the Unique Dissolution Behaviour of Nanoparticles. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Tang, P., Chan, H., Raper, J. (2009). Prediction of Aerodynamic Diameter of Particles with Corrugated Surface. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Kwok, P., Adi, H., Chan, H. (2009). Protein Nano-Matrices with Controlled Surface Roughness for Inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2009). The Importance of Agglomerate Strength on the Aerosol Performance of Pharmaceutical Dry Powders. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Hoe, S., Young, P., Chan, H., Traini, D. (2008). Electrical Next Generation Impactor (eNGI): A New Method for Aerosol Electrostatics. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Salama, R., Ladd, L., Traini, D., Chan, H., Young, P. (2008). Formulation, Characterization and In Vitro - In Vivo Evaluation of Spray Dried Pulmonary Microparticles in an Ovine Animal Model. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Kwok, P., Chan, H. (2008). Solid Forms and Electrostatic Properties of Salbutamol Sulfate. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Adi, S., Adi, H., Chan, H., Young, P., Traini, D. (2008). Use of Scanning White Light Interferometry to Evaluate the Surface Roughness and Aerosol Performance of Spherical Micron-Sized Drug Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Adi, H., Young, P., Chan, H., Traini, D., Stewart, P. (2007). Cospray dried antibiotics for dry powder inhalation delivery. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing. [More Information]
Chiou, H., Glover, W., Jun, H., Chan, H., Yun, J. (2007). Metered Dose Inhaler Performance Of High-Gravity Controlled Precipitated Salbutamol Sulfate. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
Chan, H. (2007). The Role Of Particle Morphology In Powder Inhalers. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
Kwok, P., Chan, H. (2006). Electrostatic charges of metered dose inhaler aerosols sampled from plastic spacers. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
Coates, M., Chan, H., Fletcher, D. (2006). Influence of mouthpiece geometry on the performance of a dry powder inhaler. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Young, P., Salama, R., Chan, H., Traini, D. (2006). Preparation and characterisation of controlled release microparticles for inhalation. Australasian Pharmaceutical Science Association (APSA).
Chiou, H., Li, L., Chan, H., Hu, T., Chen, R., Yun, J. (2006). Production of salbutamol sulfate powders using high gravity controlled precipitation. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Li, L., Chiou, H., Heng, D., Chan, H., Prud'homme, R., Raper, J. (2006). Studies on nano-pharmaceuticals formulated using confined impinging jets for pulmonary drug delivery. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Traini, D., Tee, H., Chiou, H., Chan, H., Young, P. (2006). The Effect of Mechanically Processed Pharmaceutical Carries for Dry Powder Inhalation on Drug Aerosolisation Performance. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Glover, W., Chan, H., Eberl, S., Daviskas, E., Verschuer, J. (2006). The Effect of Particle Size of A Powder Dry Aerosol On Lung Deposition. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Tang, P., Chan, H., Raper, J. (2006). Validation of Computation Method to Predict Aerodynamic Diameter of Particles with Rough Surface. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Tang, P., Chan, H., Schneider, C. (2002). Impact of timing valve on the invitro particle size distribution of the Bricanyl Turhuhalerï¿½. Pharmaceutical Science beyond the Genome: Harnessing the Potential, : British Medical Journal Publishing Group.
Chew, N., Bosnic-Anticevich, S., Reddel, H., Chan, H., Collis,, L. (2002). Salbutamol sulphate CFC-free metered dose inhalers: effects of washing the inhaler mouthpiece on aerosol performance and potential consequences. TSANZ Annual Scientific Meeting.
Chew, N., Chan, H., Bagster, D. (2001). Characterisation of dry powder inhalers: estimation of energy input and effect due to presence of capsule on powder dispersion. Annual Conference, : Ads & Adea.
Chew, N., Chan, H. (2001). Determinants for dispersion of powders as aerosols for inhalation. ANZSRS, : World Scientific Publishing.
Chew, N., Chan, H. (2001). Effect of the liquid properties on spray performances of thermo-liquid jet technology.
Chan, H., Chew, N., Goodall, S. (2001). Particle size estimation of therapeutic aerosols produced by thermal ink jet technology.

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Patents

Chan, H., Gonda, I., Shire, S., Weck, S. (2008). Improved DNase liquid solution. Patent No. CA-2184581-A1, JP-3009224-B2. , Canada.
Chan, H., Gonda, I., Shire, S., Weck, S. (2008). Improved DNase liquid solutions. Patent No. EP 0 748 377 B1.
Goodall, S., Waters, M., Mahler, S., Chan, H., Chew, N. (2006). Compositions for protein delivery via the pulmonary route. Patent No. EP 1 389 137 B1.
Chan, H., Gonda, I., Shire, S., Weck, S. (2006). DNase liquid solutions. Patent No. 7,018,825 B2.
Chan, H., Chiou, H., Chen, J., Hu, T., Yun, J. (2006). Inhalable Drug. Patent No. 2006096906. World.
Chan, H., Foster, N., Regtop, H., Dehghani, F., Bustami, R. (2006). Synthesis Of Small Particles. Patent No. 2002221320.
Chan, H., Clark, A., Gonda, I., Hsu, C., Mumenthaler, M., Shire, S. (2004). Pharmaceutically acceptable DNase formulation. Patent No. EP 0748225 B1.
Waters, M., Mahler, S., Chan, H., Goodall, S., Chew, N. (2003). Compositions for protein delivery via the pulmonary route. Patent No. US 2003/0064052 A1.
Chan, H., Gonda, I., Shire, S., Weck, S. (2002). Minimizing thermally induced aggregation of DNase in solution with calcium. Patent No. 6,383,788 B1.

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Reference Works

Chan, H. (2001). Radiolabelling of Pharmaceutical Aerosols and Gamma Scintigraphic Imaging for Lung Deposition. (Vol. 20, pp. 255-268).

By Year

Expand all

2024

Milton-McGurk, L., Kourmatzis, A., Chan, H., Cheng, S., Masri, A., Farina, D. (2024). A new LED-based extinction tomography method for measurement of aerosol surface area. Journal of Aerosol Science, 181, 106432. [More Information]
Ma, Z., Milton-McGurk, L., Tang, P., Chan, H., Farina, D., Cheng, S., Kourmatzis, A. (2024). An experimental study of the effect of individual upper airway anatomical features on the deposition of dry powder inhaler formulations. Journal of Aerosol Science, 177, 106320. [More Information]
Zhu, Q., Gou, D., Chan, H., Yang, R. (2024). CFD-DEM investigation of the dispersion of elongated particles in the Turbuhaler® aerosol device. Powder Technology, 437, 119565. [More Information]
Kumar, A., Kourmatzis, A., Chan, H., Cheng, S., Singh, G. (2024). Effect of transient inhalation on powder evacuation and dispersion in a typical dual air inlet dry powder inhaler. Journal of Aerosol Science, 175, 106287. [More Information]
Gou, D., Zhu, Q., Chan, H., Kourmatzis, A., Cheng, S., Yang, R. (2024). Effects of the deformation and size of the upper airway on the deposition of aerosols. International Journal of Pharmaceutics, 657, 124165. [More Information]
Tai, W., Yau, G., Arnold, J., Chan, H., Kwok, P. (2024). High-loading cannabidiol powders for inhalation. International Journal of Pharmaceutics, 660, 124370. [More Information]
Zhang, J., Khanal, D., Chan, H., Banaszak Holl, M. (2024). Nanoscale colocalized thermal and chemical mapping of pharmaceutical powder aerosols. International Journal of Pharmaceutics, 656, 124116. [More Information]
Au-Doung, P., Li, A., Leung, S., Chan, J., Kui, O., Ho, M., Cheung, Y., Lam, J., Chan, H., Brannan, J., et al (2024). Objective monitoring tools for improved management of childhood asthma. Respiratory Research, 25(1), 194. [More Information]
Byun, A., Vitetta, L., Chan, H., Kwok, P. (2024). Respiratory Delivery of Lacticaseibacillus rhamnosus GG by Vibrating-Mesh and Jet Nebulisation. Pharmaceutics, 16(10), 1326. [More Information]
Tai, W., Arnold, J., Chan, H., Kwok, P. (2024). Spray freeze dried cannabidiol with dipalmitoylphosphatidylcholine (DPPC) for inhalation and solubility enhancement. International Journal of Pharmaceutics, 659, 124235. [More Information]

show 7 more

2023

Wang, Y., Khanal, D., Alreja, A., Yang, H., Chang, R., Tai, W., Li, M., Nelson, D., Britton, W., Chan, H. (2023). Bacteriophage endolysin powders for inhaled delivery against pulmonary infections. International Journal of Pharmaceutics, 635. [More Information]
Yau, G., Tai, W., Arnold, J., Chan, H., Kwok, P. (2023). Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration. Pharmaceutical Research. [More Information]
Zhu, Q., Kakhi, M., Jayasundara, C., Walenga, R., Behara, S., Chan, H., Yang, R. (2023). CFD-DEM investigation of the effects of aperture size for a capsule-based dry powder inhaler. International Journal of Pharmaceutics, 647, 123556. [More Information]
Zhu, Q., Gou, D., Chan, H., Kourmatzis, A., Yang, R. (2023). Effects of the mouthpiece and chamber of Turbuhaler® on the aerosolization of API-only powder formulations. International Journal of Pharmaceutics, 637. [More Information]
Shen, Z., Dong, J., Milton-McGurk, L., Cai, X., Gholizadeh, H., Chan, H., Lee, A., Kourmatzis, A., Cheng, S. (2023). Numerical analysis of airflow and particle deposition in multi-fidelity designs of nasal replicas following nasal administration. Computer Methods and Programs in Biomedicine, 241, 107778. [More Information]
Khanal, D., Kim, J., Zhang, J., Ke, W., Holl, M., Chan, H. (2023). Optical photothermal infrared spectroscopy for nanochemical analysis of pharmaceutical dry powder aerosols. International Journal of Pharmaceutics, 632. [More Information]
Nang, S., Lin, Y., Petrovic Fabijan, A., Chang, R., Rao, G., Iredell, J., Chan, H., Li, J. (2023). Pharmacokinetics/pharmacodynamics of phage therapy: a major hurdle to clinical translation. Clinical Microbiology and Infection. [More Information]
Azeem, A., Singh, G., Li, L., Chan, H., Yang, R., Cheng, S., Kourmatzis, A. (2023). Quantifying Agglomerate-to-Wall Impaction in Dry Powder Inhalers. Pharmaceutical Research, 40(1), 307-319. [More Information]
Flint, R., Laucirica, D., Chan, H., Chang, B., Stick, S., Kicic, A. (2023). Stability Considerations for Bacteriophages in Liquid Formulations Designed for Nebulization. Cells, 12(16). [More Information]
Tang, P., Kakhi, M., Albariqi, A., Ravindra Babu Behara, S., Walenga, R., Yang, R., Chan, H. (2023). The role of capsule aperture size on the dispersion of carrier-based formulation at different air flowrates. International Journal of Pharmaceutics, 642. [More Information]
Cai, X., Dong, J., Milton-McGurk, L., Lee, A., Shen, Z., Chan, H., Kourmatzis, A., Cheng, S. (2023). Understanding the effects of inhaler resistance on particle deposition behaviour – A computational modelling study. Computers in Biology and Medicine, 167, 107673. [More Information]

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2022

Chang, R., Li, M., Chow, M., Ke, W., Tai, W., Chan, H. (2022). A dual action of D-amino acids on anti-biofilm activity and moisture-protection of inhalable ciprofloxacin powders. European Journal of Pharmaceutics and Biopharmaceutics, 173, 132-140. [More Information]
Chang, R., Chan, H. (2022). Advancements in Particle Engineering for Inhalation Delivery of Small Molecules and Biotherapeutics. Pharmaceutical Research, 39(12), 3047-3061. [More Information]
Wang, Y., Chang, R., Britton, W., Chan, H. (2022). Advances in the development of antimicrobial peptides and proteins for inhaled therapy. Advanced Drug Delivery Reviews, 180, 114066. [More Information]
Han, M., Nang, S., Lin, Y., Zhu, Y., Yu, H., Wickremasinghe, H., Barlow, C., Creek, D., Crawford, S., Rao, G., Chan, H., et al (2022). Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination. Computational and Structural Biotechnology Journal, 20, 485-495. [More Information]
Burchell, C., Kourmatzis, A., Zhao, Y., Raco, J., Mekonnen, T., Chan, H., Cheng, S. (2022). Effects of respiratory rate on the fluid mechanics of a reconstructed upper airway. Medical Engineering and Physics, 100, 103746. [More Information]
Leung, S., Chan, H. (2022). Emerging antibiotic alternatives: From antimicrobial peptides to bacteriophage therapies. Advanced Drug Delivery Reviews, 191, 114594. [More Information]
Ke, W., Chang, R., Chan, H. (2022). Engineering the right formulation for enhanced drug delivery. Advanced Drug Delivery Reviews, 191. [More Information]
Singh, G., Tang, P., Cheng, S., Chan, H., Kourmatzis, A. (2022). From laminar to turbulent flow in a dry powder inhaler: The effect of simple design modifications. International Journal of Pharmaceutics, 616, 121556. [More Information]
Chan, H., Chang, R. (2022). Inhaled Delivery of Anti-Pseudomonal Phages to Tackle Respiratory Infections Caused by Superbugs. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 35(2), 73-82. [More Information]
Chang, R., Nang, S., Chan, H., Li, J. (2022). Novel antimicrobial agents for combating antibiotic-resistant bacteria. Advanced Drug Delivery Reviews, 187. [More Information]
Zhu, Q., Gou, D., Li, L., Chan, H., Yang, R. (2022). Numerical investigation of powder dispersion mechanisms in Turbuhaler and the contact electrification effect. Advanced Powder Technology, 33(11). [More Information]
Liu, C., Hong, Q., Chang, R., Kwok, P., Chan, H. (2022). Phage-Antibiotic Therapy as a Promising Strategy to Combat Multidrug-Resistant Infections and to Enhance Antimicrobial Efficiency. Antibiotics, 11(5), 570. [More Information]
Bian, X., Qu, X., Zhang, J., Nang, S., Bergen, P., Tony. Zhou, Q., Chan, H., Feng, M., Li, J. (2022). Pharmacokinetics and pharmacodynamics of peptide antibiotics. Advanced Drug Delivery Reviews, 183, 114171. [More Information]
Albariqi, A., Wang, Y., Chang, R., Quan, D., Wang, X., Kalfas, S., Drago, J., Britton, W., Chan, H. (2022). Pharmacokinetics and safety of inhaled ivermectin in mice as a potential COVID-19 treatment. International Journal of Pharmaceutics, 619, 121688. [More Information]
Li, M., Azad, M., Ahmed, M., Zhu, Y., Song, J., Zhou, F., Chan, H., Velkov, T., Zhou, Q., Li, J. (2022). Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells. Antibiotics, 11(3), 307. [More Information]
Cai, X., Ma, B., Kourmatzis, A., Salehi, F., Lee, A., Farina, D., Chan, H., Cheng, S. (2022). Potential effects of inhaler mouthpiece size on particle deposition in the human upper airway. Aerosol Science and Technology, 56(9), 802-818. [More Information]
Albariqi, A., Ke, W., Khanal, D., Kalfas, S., Tang, P., Britton, W., Drago, J., Chan, H. (2022). Preparation and Characterization of Inhalable Ivermectin Powders as a Potential COVID-19 Therapy. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 35(5), 239-251. [More Information]
Khanal, D., Ke, W., Chan, H. (2022). Raman spectroscopic evaluation of crystallinity, chemical composition and stability of pharmaceutical powder aerosols. International Journal of Pharmaceutics, 611, 121341. [More Information]
Ma, Z., Kourmatzis, A., Milton-McGurk, L., Chan, H., Farina, D., Cheng, S. (2022). Simulating the effect of individual upper airway anatomical features on drug deposition. International Journal of Pharmaceutics, 628. [More Information]
Chang, R., Chow, M., Wang, Y., Liu, C., Hong, Q., Morales, S., McLachlan, A., Kutter, E., Li, J., Chan, H. (2022). The effects of different doses of inhaled bacteriophage therapy for Pseudomonas aeruginosa pulmonary infections in mice. Clinical Microbiology and Infection, 28(7), 983-989. [More Information]
Chang, R., Okamoto, Y., Morales, S., Kutter, E., Chan, H. (2022). Topical liquid formulation of bacteriophages for metered-dose spray delivery. European Journal of Pharmaceutics and Biopharmaceutics, 177, 1-8. [More Information]

show 18 more

2021

Yaqoubi, S., Chan, H., Nokhodchi, A., Dastmalchi, S., Alizadeh, A., Barzegar-Jalali, M., Adibkia, K., Hamishehkar, H. (2021). A quantitative approach to predicting lung deposition profiles of pharmaceutical powder aerosols. International Journal of Pharmaceutics, 602, 120568. [More Information]
Ke, W., Chang, R., Kwok, P., Tang, P., Chen, L., Chen, D., Chan, H. (2021). Administration of dry powders during respiratory supports. Annals of Translational Medicine, 9(7), 596. [More Information]
Kim, H., Chang, R., Morales, S., Chan, H. (2021). Bacteriophage-delivering hydrogels: Current progress in combating antibiotic resistant bacterial infection. Antibiotics, 10(2), 130-1-130-17. [More Information]
Ke, W., Kwok, P., Khanal, D., Chang, R., Chan, H. (2021). Co-spray dried hydrophobic drug formulations with crystalline lactose for inhalation aerosol delivery. International Journal of Pharmaceutics, 602, 120608-1-120608-10. [More Information]
Khoubnasabjafari, M., Fathi-Azarbayjani, A., Rahimpour, E., Jouyban-Gharamaleki, V., Kim, H., Alffenaar, J., Chan, H., Jouyban, A. (2021). Concentration profile of tobramycin in exhaled breath condensate after inhalation of a single dose: A pilot study. Journal of Drug Delivery Science and Technology, 62, 102394. [More Information]
Chang, R., Chow, M., Khanal, D., Chen, D., Chan, H. (2021). Dry powder pharmaceutical biologics for inhalation therapy. Advanced Drug Delivery Reviews, 172, 64-79. [More Information]
Singh, G., Lowe, A., Azeem, A., Cheng, S., Chan, H., Walenga, R., Kourmatzis, A. (2021). Effect of inflow conditioning for dry powder inhalers. International Journal of Pharmaceutics, 608, 121085-1-121085-15. [More Information]
Khanal, D., Chang, R., Hick, C., Morales, S., Chan, H. (2021). Enteric-coated bacteriophage tablets for oral administration against gastrointestinal infections. International Journal of Pharmaceutics, 609, 121206. [More Information]
Singh, G., Kourmatzis, A., Lowe, A., Masri, A., Chan, H., Cheng, S. (2021). Extending the range of back-lit imaging in two-phase flows using an interrogation-window based method. Measurement, 176, 109155. [More Information]
Elserfy, K., Kourmatzis, A., Singh, G., Chan, H., Cheng, S. (2021). Fluidization of lactose carrier powders through normally directed airflow: The effect of recirculation and particle size. Advanced Powder Technology, 32(9), 3297-3313. [More Information]
Lowe, A., Singh, G., Chan, H., Masri, A., Cheng, S., Kourmatzis, A. (2021). Fragmentation dynamics of single agglomerate-to-wall impaction. Powder Technology, 378, 561-575. [More Information]
Kwok, P., Li, D., Tang, P., Fincher, L., Browne, E., Finlay, W., Chan, H. (2021). Generation and characterization of electrostatically charged radiolabelled aerosols for lung scintigraphy. Aerosol Science and Technology, 55(6), 640-652. [More Information]
Chang, R., Okamoto, Y., Morales, S., Kutter, E., Chan, H. (2021). Hydrogel formulations containing non-ionic polymers for topical delivery of bacteriophages. International Journal of Pharmaceutics, 605, 120850-1-120850-7. [More Information]
Chow, M., Tai, W., Chang, R., Chan, H., Kwok, P. (2021). In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols. Advanced Drug Delivery Reviews, 177, 113952-1-113952-10. [More Information]
Albariqi, A., Chang, R., Tai, W., Ke, W., Chow, M., Tang, P., Kwok, P., Chan, H. (2021). Inhalable Hydroxychloroquine Powders for Potential Treatment of COVID-19. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 34(1), 20-31. [More Information]
Chow, M., Chang, R., Chan, H. (2021). Inhalation delivery technology for genome-editing of respiratory diseases. Advanced Drug Delivery Reviews, 168, 217-228. [More Information]
Chang, R., Chan, H. (2021). Lipid nanoparticles for the inhalation of mRNA. Nature Biomedical Engineering, 5(9), 949-950. [More Information]
Elserfy, K., Cheng, S., Chan, H., Kourmatzis, A. (2021). Local dynamics of pharmaceutical powder fluidization using high speed long distance microscopy and particle image velocimetry. Experimental Thermal and Fluid Science, 124, 110367. [More Information]
Khatib, I., Chow, M., Ruan, J., Cipolla, D., Chan, H. (2021). Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design. International Journal of Pharmaceutics, 597, 120277. [More Information]
Tai, W., Chow, M., Chang, R., Tang, P., Chan, H., Kwok, P. (2021). Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19. Pharmaceutics, 13(8), 1260. [More Information]
Li, M., Chang, R., Lin, Y., Morales, S., Kutter, E., Chan, H. (2021). Phage cocktail powder for Pseudomonas aeruginosa respiratory infections. International Journal of Pharmaceutics, 596, 120200. [More Information]
Iszatt, J., Larcombe, A., Chan, H., Stick, S., Garratt, L., Kicic, A. (2021). Phage therapy for multi-drug resistant respiratory tract infections. Viruses, 13(9), 1809. [More Information]
Chow, M., Chang, R., Li, M., Wang, Y., Lin, Y., Morales, S., McLachlan, A., Kutter, E., Li, J., Chan, H. (2021). Pharmacokinetics and time-kill study of inhaled antipseudomonal bacteriophage therapy in mice. Antimicrobial Agents and Chemotherapy, 65(1), e01470-20-1-e01470-20-12. [More Information]
Ahmed, M., Azad, M., Li, M., Creek, D., Han, M., Zhou, F., Chan, H., Zhou, Q., Velkov, T., Li, J. (2021). Polymyxins induced metabolic perturbations in human lung epithelial cells. Antimicrobial Agents and Chemotherapy, 65(9), e00835-21-1-e00835-21-13. [More Information]
Khatib, I., Ke, W., Cipolla, D., Chan, H. (2021). Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin nanocrystal-containing liposomes. International Journal of Pharmaceutics, 605, 120809-1-120809-12. [More Information]
Lin, Y., Quan, D., Chang, R., Chow, M., Wang, Y., Li, M., Morales, S., Britton, W., Kutter, E., Li, J., Chan, H. (2021). Synergistic activity of phage PEV20-ciprofloxacin combination powder formulation—A proof-of-principle study in a P. aeruginosa lung infection model. European Journal of Pharmaceutics and Biopharmaceutics, 158, 166-171. [More Information]

show 23 more

2020

Khanal, D., Zhang, J., Ke, W., Banaszak Holl, M., Chan, H. (2020). Bulk to Nanometer-Scale Infrared Spectroscopy of Pharmaceutical Dry Powder Aerosols. Analytical Chemistry, 92(12), 8323-8332. [More Information]
Wang, Y., Khanal, D., Chang, R., Shang, X., Yang, H., Britton, W., Nelson, D., Chan, H. (2020). Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae? International Journal of Pharmaceutics, 591, 1-8. [More Information]
Chang, R., Kwok, P., Ghassabian, S., Brannan, J., Koskela, H., Chan, H. (2020). Cough as an adverse effect on inhalation pharmaceutical products. British Journal of Pharmacology, 177(18), 4096-4112. [More Information]
Elserfy, K., Kourmatzis, A., Chan, H., Walenga, R., Cheng, S. (2020). Effect of an upstream grid on the fluidization of pharmaceutical carrier powders. International Journal of Pharmaceutics, 578, 1-10. [More Information]
Khatib, I., Tang, P., Ruan, J., Cipolla, D., Dayton, F., Blanchard, J., Chan, H. (2020). Formation of ciprofloxacin nanocrystals within liposomes by spray drying for controlled release via inhalation. International Journal of Pharmaceutics, 578, 119045. [More Information]
Marqus, S., Lee, L., Istivan, T., Kyung Chang, R., Dekiwadia, C., Chan, H., Yeo, L. (2020). High frequency acoustic nebulization for pulmonary delivery of antibiotic alternatives against Staphylococcus aureus. European Journal of Pharmaceutics and Biopharmaceutics, 151, 181-188. [More Information]
Kwok, P., Seungyeon, B., Ong, Y., Bhome, A., Tang, P., Chan, H. (2020). In vitro aerosol performance of originator and generic fixed dose combination metered dose inhalers. Respiratory Drug Delivery 2020, Digital: Respiratory Drug Delivery 2020.
Tai, W., Bhome, A., Tang, P., Chan, H., Kwok, P. (2020). In Vitro Aerosol Performance Of Originator And Indian Generic Fixed-dose Combination Dry Powder Inhalers. Respiratory Drug Delivery 2020, Digital: Respiratory Drug Delivery 2020.
Newman, S., Chan, H. (2020). In vitro-in vivo correlations (IVIVCs) of deposition for drugs given by oral inhalation. Advanced Drug Delivery Reviews, 167, 135-147. [More Information]
Kwok, P., McDonnell, A., Tang, P., Knight, C., McKay, E., Butler, S., Sivarajah, A., Quinn, R., Fincher, L., Browne, E., Chan, H., et al (2020). In vivo deposition study of a new generation nebuliser utilising hybrid resonant acoustic (HYDRA) technology. International Journal of Pharmaceutics, 580, 119196. [More Information]
Chang, R., Kwok, P., Khanal, D., Morales, S., Kutter, E., Li, J., Chan, H. (2020). Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization. Bioengineering & Translational Medicine, 5(2), 1-10. [More Information]
Samini, L., Khoubnasabjafari, M., Alimorad, M., Jouyban-Gharamaleki, V., Chan, H., Jouyban, A. (2020). Microextraction and chromatographic analysis of budesonide epimers in exhaled breath condensate. Current Analytical Chemistry, 16(8), 1032-1040. [More Information]
Khanal, D., Khatib, I., Ruan, J., Cipolla, D., Drayton, F., Blanchard, J., Chan, H., Chrzanowski, W. (2020). Nanoscale Probing of Liposome Encapsulating Drug Nanocrystal Using Atomic Force Microscopy-Infrared Spectroscopy. Analytical Chemistry, 92(14), 9922-9931. [More Information]
Yu, S., Yuan, H., Chai, G., Peng, K., Zou, P., Li, X., Li, J., Zhou, F., Chan, H., Zhou, Q. (2020). Optimization of inhalable liposomal powder formulations and evaluation of their in vitro drug delivery behavior in Calu-3 human lung epithelial cells. International Journal of Pharmaceutics, 586, 119570. [More Information]
Chang, R., Chen, L., Chen, D., Chan, H. (2020). Overcoming challenges for development of amorphous powders for inhalation. Expert Opinion on Drug Delivery, 17(11), 1583-1595. [More Information]
Lin, Y., Chang, R., Rao, G., Jermain, B., Han, M., Zhao, J., Chen, K., Wang, J., Barr, J., Schooley, R., Chan, H., et al (2020). Pharmacokinetics/pharmacodynamics of antipseudomonal bacteriophage therapy in rats: a proof-of-concept study. Clinical Microbiology and Infection, 26(9), 1229-1235. [More Information]
Sato, H., Kaneko, Y., Yamada, K., Ristroph, K., Lu, H., Seto, Y., Chan, H., Prud'homme, R., Onoue, S. (2020). Polymeric Nanocarriers With Mucus-Diffusive and Mucus-Adhesive Properties to Control Pharmacokinetic Behavior of Orally Dosed Cyclosporine A. Journal of Pharmaceutical Sciences, 109(2), 1079-1085. [More Information]
Ma, B., Kourmatzis, A., Zhao, Y., Yang, R., Chan, H., Salehi, F., Cheng, S. (2020). Potential effects of lingual fats on airway flow dynamics and particle deposition. Aerosol Science and Technology, 54(3), 321-331. [More Information]
Chow, M., Kwok, P., Yang, R., Chan, H. (2020). Predicting the composition and size distribution of dry particles for aerosols and sprays of suspension: A Monte Carlo approach. International Journal of Pharmaceutics, 582, 119311. [More Information]
Ke, W., Chang, R., Kwok, P., Chen, D., Chan, H. (2020). Spray drying lactose from organic solvent suspensions for aerosol delivery to the lungs. International Journal of Pharmaceutics, 591, 119984. [More Information]
Lin, Y., Chang, R., Britton, W., Morales, S., Kutter, E., Li, J., Chan, H. (2020). Storage stability of phage-ciprofloxacin combination powders against Pseudomonas aeruginosa respiratory infections. International Journal of Pharmaceutics, 591, 119952. [More Information]
Shetty, N., Zhang, Y., Park, H., Zemlyanov, D., Shah, D., He, A., Ahn, P., Mutukuri, T., Chan, H., Zhou, Q. (2020). Surface Composition and Aerosolization Stability of an Inhalable Combinational Powder Formulation Spray Dried Using a Three-Fluid Nozzle. Pharmaceutical Research, 37(11), 219. [More Information]
Zhao, Y., Raco, J., Kourmatzis, A., Diasinos, S., Chan, H., Yang, R., Cheng, S. (2020). The effects of upper airway tissue motion on airflow dynamics. Journal of Biomechanics, 99, 109506. [More Information]
Chang, R., Morales, S., Okamoto, Y., Chan, H. (2020). Topical application of bacteriophages for treatment of wound infections. Translational Research: the journal of laboratory and clinical medicine, 220, 153-166. [More Information]
Lin, Y., Aye, S., Rao, G., Zhou, Q., Chan, H., Li, J. (2020). Treatment of infections caused by Gram-negative pathogens: current status on the pharmacokinetics/pharmacodynamics of parenteral and inhaled polymyxins in patients. International Journal of Antimicrobial Agents, 56(6), 106199. [More Information]
An Le, N., Deng, H., Devendran, C., Akhtar, N., Ma, X., Pouton, C., Chan, H., Neild, A., Alan, T. (2020). Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis. Lab on a Chip, 20(3), 582-591. [More Information]

show 23 more

2019

Khoubnasabjafari, M., Rahimpour, E., Samini, M., Jouyban-Gharamaleki, V., Chen, L., Chen, D., Chan, H., Jouyban, A. (2019). A new hypothesis to investigate bioequivalence of pharmaceutical inhalation products. DARU Journal of Pharmaceutical Sciences, 27(1), 517-524. [More Information]
Wallin, M., Tang, P., Chang, R., Yang, M., Finlay, W., Chan, H. (2019). Aerosol drug delivery to the lungs during nasal high flow therapy: an in vitro study. BMC Pulmonary Medicine, 19(1), 1-11. [More Information]
Abdelghany, S., Parumasivam, T., Pang, A., Roediger, B., Tang, P., Jahn, K., Britton, W., Chan, H. (2019). Alginate modified-PLGA nanoparticles entrapping amikacin and moxifloxacin as a novel host-directed therapy for multidrug-resistant tuberculosis. Journal of Drug Delivery Science and Technology, 52, 642-651. [More Information]
Lu, W., Rades, T., Rantanen, J., Chan, H., Yang, M. (2019). Amino acids as stabilizers for spray-dried simvastatin powder for inhalation. International Journal of Pharmaceutics, 572, 1-12. [More Information]
Chang, R., Das, T., Manos, J., Kutter, E., Morales, S., Chan, H. (2019). Bacteriophage PEV20 and Ciprofloxacin Combination Treatment Enhances Removal of Pseudomonas aeruginosa Biofilm Isolated from Cystic Fibrosis and Wound Patients. The AAPS Journal, 21(3), 1-8. [More Information]
Kim, Y., Tong, Z., Chan, H., Yang, R. (2019). CFD modelling of air and particle flows in different airway models. Journal of Aerosol Science, 134, 14-28. [More Information]
Khatib, I., Khanal, D., Ruan, J., Cipolla, D., Dayton, F., Blanchard, J., Chan, H. (2019). Ciprofloxacin nanocrystals liposomal powders for controlled drug release via inhalation. International Journal of Pharmaceutics, 566, 641-651. [More Information]
Cheng, S., Kourmatzis, A., Mekonnen, T., Gholizadeh, H., Raco, J., Chen, L., Tang, P., Chan, H. (2019). Does upper airway deformation affect drug deposition? International Journal of Pharmaceutics, 572, 2-8. [More Information]
Mahmoudi, S., Elserfy, K., Cheng, S., Chan, H., Hebbink, G., Kourmatzis, A. (2019). Fluidisation characteristics of lactose powders in simple turbulent channel flows. Experimental Thermal and Fluid Science, 103, 201-213. [More Information]
Khanal, D., Chang, R., Morales, S., Chan, H., Chrzanowski, W. (2019). High Resolution Nanoscale Probing of Bacteriophages in an Inhalable Dry Powder Formulation for Pulmonary Infections. Analytical Chemistry, 91(20), 12760-12767. [More Information]
Chow, M., Qiu, Y., Liao, Q., Kwok, P., Chow, S., Chan, H., Lam, J. (2019). High siRNA loading powder for inhalation prepared by co-spray drying with human serum albumin. International Journal of Pharmaceutics, 572, 1-11. [More Information]
Lin, Y., Chang, R., Britton, W., Morales, S., Cutter, E., Li, J., Chan, H. (2019). Inhalable combination powder formulations of phage and ciprofloxacin for P. aeruginosa respiratory infections. European Journal of Pharmaceutics and Biopharmaceutics, 142, 543-552. [More Information]
Ahmed, M., Velkov, T., Zhou, Q., Fulcher, A., Callaghan, J., Zhou, F., Chan, H., Azad, M., Li, J. (2019). Intracellular localization of polymyxins in human alveolar epithelial cells. Journal of Antimicrobial Chemotherapy, 74(1), 48-57. [More Information]
Leung, S., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Carter, E., Britton, W., Kutter, E., Chan, H. (2019). Jet nebulization of bacteriophages with different tail morphologies - Structural effects. International Journal of Pharmaceutics, 554, 322-326. [More Information]
Liao, Q., Yip, L., Chow, M., Chow, S., Chan, H., Kwok, P., Lam, J. (2019). Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition. International Journal of Pharmaceutics, 560, 144-154. [More Information]
Kwok, P., Chan, H. (2019). Solid State Testing of Inhaled Formulations. In Anthony J. Hickey, Sandro R.P. da Rocha (Eds.), Pharmaceutical Inhalation Aerosol Technology, (pp. 523-540). Boca Raton: CRC Press. [More Information]
Ashish Kumar, T., Choong, H., Kwang, Y., Chan, H., Manos, J., Kwok, P., Duong, H. (2019). Spray-Dried Particles of Nitric Oxide-Modified Glutathione for the Treatment of Chronic Lung Infection. Molecular Pharmaceutics, 16(4), 1723-1731. [More Information]
Chang, R., Wallin, M., Kutter, E., Morales, S., Britton, W., Li, J., Chan, H. (2019). Storage stability of inhalable phage powders containing lactose at ambient conditions. International Journal of Pharmaceutics, 560, 11-18. [More Information]
Kwok, P., Chan, H., Wallin, M., Dolovich, M. (2019). Studies of Radioaerosol Deposition in the Respiratory Tract. Seminars in Nuclear Medicine, 49(1), 62-70. [More Information]
Mangal, S., Xu, R., Park, H., Zemlyanov, D., Shetty, N., Lin, Y., Morton, D., Chan, H., Li, J., Zhou, Q. (2019). Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation. Pharmaceutical Research, 36(1), 1-15. [More Information]

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2018

Dhanani, J., Cohen, J., Parker, S., Chan, H., Tang, P., Ahern, B., Khan, A., Bhatt, M., Goodman, S., Diab, S., et al (2018). A research pathway for the study of the delivery and disposition of nebulised antibiotics: an incremental approach from in vitro to large animal models. Intensive Care Medicine Experimental, 6(1), 1-19. [More Information]
Le, N., Phan, H., Yu, J., Chan, H., Neild, A., Alan, T. (2018). Acoustically enhanced microfluidic mixer to synthesize highly uniform nanodrugs without the addition of stabilizers. International Journal of Nanomedicine, 13, 1353-1359. [More Information]
Reczynska, K., Tharkar, P., Kim, S., Wang, Y., Pamula, E., Chan, H., Chrzanowski, W. (2018). Animal Models of Smoke Inhalation Injury and Related Acute and Chronic Lung Diseases. Advanced Drug Delivery Reviews, 123, 107-134. [More Information]
Dhanani, J., Tang, P., Wallis, S., Parker, S., Pandey, P., Fraser, J., Cohen, J., Barnett, A., Roberts, J., Chan, H. (2018). Characterisation of 40mg/ml and 100mg/ml tobramycin formulations for aerosol therapy with adult mechanical ventilation. Pulmonary Pharmacology & Therapeutics, 50, 93-99. [More Information]
Wallin, M., Turner, P., Katsifis, A., Yang, M., Chan, H. (2018). Crystal structure of aqua(2-{[2-({2-[bis(carboxylato-kappa O-methyl)amino-kappa N]ethyl}(carboxylato-kappa O-methyl) amino-kappa N)ethyl](carboxymethyl)azanium-yl}acetato)gallium(III) trihydrate. Acta Crystallographica Section E, E74, 1054-1057. [More Information]
Leung, S., Parumasivam, T., Nguyen, A., Gegenbach, T., Carter, E., Carrigy, N., Wang, H., Vehring, R., Finlay, W., Morales, S., Britton, W., Chan, H., et al (2018). Effect of storage temperature on the stability of spray dried bacteriophage powders. European Journal of Pharmaceutics and Biopharmaceutics, 127, 213-222. [More Information]
Lin, Y., Zhou, Q., Han, M., Chen, K., Onufrak, N., Wang, J., Turnidge, J., Howden, B., Forrest, A., Chan, H., et al (2018). Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy, 62(2), 1-9. [More Information]
Lee, S., Heng, D., Xavier, V., Chan, K., Ng, W., Zhao, Y., Chan, H., Tan, R. (2018). Inhaled non-steroidal polyphenolic alternatives for anti-inflammatory combination therapy. Powder Technology, 339, 244-255. [More Information]
Lin, Y., Zhou, Q., Han, M., Onufrak, N., Chen, K., Wang, J., Forrest, A., Chan, H., Li, J. (2018). Mechanism-based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model. Antimicrobial Agents and Chemotherapy, 62(3), 1-14. [More Information]
Leung, S., Morales, S., Britton, W., Kutter, E., Chan, H. (2018). Microfluidic-assisted bacteriophage encapsulation into liposomes. International Journal of Pharmaceutics, 545(1-Feb), 176-182. [More Information]
Astudillo, A., Leung, S., Kutter, E., Morales, S., Chan, H. (2018). Nebulization effects on structural stability of bacteriophage PEV 44. European Journal of Pharmaceutics and Biopharmaceutics, 125, 124-130. [More Information]
Ye, T., Sun, S., Sugianto, T., Tang, P., Parumasivam, T., Chang, R., Astudillo, A., Wang, S., Chan, H. (2018). Novel combination proliposomes containing tobramycin and clarithromycin effective against Pseudomonas aeruginosa biofilms. International Journal of Pharmaceutics, 552(1-Feb), 130-138. [More Information]
Dong, J., Shang, Y., Inthavong, K., Chan, H., Tu, J. (2018). Numerical Comparison of Nasal Aerosol Administration Systems for Efficient Nose-to-Brain Drug Delivery. Pharmaceutical Research, 35(5), 1-12. [More Information]
Dong, J., Shang, Y., Inthavong, K., Chan, H., Tu, J. (2018). Partitioning of dispersed nanoparticles in a realistic nasal passage for targeted drug delivery. International Journal of Pharmaceutics, 543, 83-95. [More Information]
Chang, R., Wallin, M., Lin, Y., Leung, S., Wang, H., Morales, S., Chan, H. (2018). Phage therapy for respiratory infections. Advanced Drug Delivery Reviews, 133, 76-86. [More Information]
Ashhurst, A., Parumasivam, T., Chan, J., Lin, L., Florido, M., West, N., Chan, H., Britton, W. (2018). PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection. PloS One, 13(3). [More Information]
Chang, R., Chen, K., Wang, J., Wallin, M., Britton, W., Morales, S., Kutter, E., Li, J., Chan, H. (2018). Proof-of-Principle Study in a Murine Lung Infection Model of Antipseudomonal Activity of Phage PEV20 in a Dry-Powder Formulation. Antimicrobial Agents and Chemotherapy, 62(2), 1-8. [More Information]
Yu, J., Romeo, M., Cavallaro, A., Chan, H. (2018). Protective effect of sodium stearate on the moisture-induced deterioration of hygroscopic spray-dried powders. International Journal of Pharmaceutics, 541(1-2), 11-18. [More Information]
Wallin, M., Takami, T., Chen, L., Yang, M., Chan, H. (2018). Pulmonary drug delivery to older people. Advanced Drug Delivery Reviews, 135, 50-61. [More Information]
Anderson, S., Daviskas, E., Brannan, J., Chan, H. (2018). Repurposing excipients as active inhalation agents: The mannitol story. Advanced Drug Delivery Reviews, 133, 45-56. [More Information]
Lin, Y., Chang, R., Britton, W., Morales, S., Kutter, E., Chan, H. (2018). Synergy of nebulized phage PEV20 and ciprofloxacin combination against Pseudomonas aeruginosa. International Journal of Pharmaceutics, 551, 158-165. [More Information]
Lu, X., Chan, T., Zhu, L., Bao, X., Velkov, T., Zhou, Q., Li, J., Chan, H., Zhou, F. (2018). The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models. European Journal of Pharmaceutical Sciences, 115, 132-143. [More Information]
Liang, W., Chow, M., Chow, S., Chan, H., Kwok, P., Lam, J. (2018). Using Two-Fluid Nozzle for Spray Freeze Drying to Produce Porous Powder Formulation of Naked siRNA for Inhalation. International Journal of Pharmaceutics, 552(1-2), 67-75. [More Information]

show 20 more

2017

Feng, B., Tang, P., Leung, S., Dhanani, J., Chan, H. (2017). A Novel In-Line Delivery System to Administer Dry Powder Mannitol to Mechanically Ventilated Patients. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30(2), 100-107. [More Information]
Lin, Y., Zhou, Q., Onufrak, N., Wirth, V., Chen, K., Wang, J., Forrest, A., Chan, H., Li, J. (2017). Aerosolized polymyxin B for treatment of respiratory tract infections: Determination of pharmacokinetic-pharmacodynamic indices for aerosolized polymyxin B against Pseudomonas aeruginosa in a mouse lung infection model. Antimicrobial Agents and Chemotherapy, 61(8), 1-15. [More Information]
Kourmatzis, A., Cheng, S., Chan, H. (2017). Airway geometry, airway flow, and particle measurement methods: implications on pulmonary drug delivery. Expert Opinion on Drug Delivery, 15(3), 271-282. [More Information]
Carrigy, N., Chang, R., Leung, S., Harrison, M., Petrova, Z., Pope, W., Hatfull, G., Britton, W., Chan, H., Sauvageau, D., et al (2017). Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler. Pharmaceutical Research, 34(10), 2084-2096. [More Information]
Zhang, Y., Feng, J., McManus, S., Lu, H., Ristroph, K., Cho, E., Dobrijevic, E., Chan, H., Prud'homme, R. (2017). Design and Solidification of Fast-Releasing Clofazimine Nanoparticles for Treatment of Cryptosporidiosis. Molecular Pharmaceutics, 14(10), 3480-3488. [More Information]
Yu, J., Wong, J., Ukkonen, A., Kannosto, J., Chan, H. (2017). Effect of Relative Humidity on Bipolar Electrostatic Charge Profiles of dry Powder Aerosols. Pharmaceutical Research, 34(8), 1707-1715. [More Information]
Leung, S., Chiow, A., Kwok, P., Ukkonen, A., Chan, H. (2017). Effect of Spacers on the Bipolar Electrostatic Charge Properties of Metered Dose Inhaler Aerosols—A Case Study With Tilade. Journal of Pharmaceutical Sciences, 106(6), 1553-1559. [More Information]
Leung, S., Parumasivam, T., Gao, G., Carter, E., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Britton, W., Kutter, E., Chan, H. (2017). Effects of storage conditions on the stability of spray dried, inhalable bacteriophage powders. International Journal of Pharmaceutics, 521(1-2), 141-149. [More Information]
Yang, M., Ruzycki, C., Verschuer, J., Katsifis, A., Eberl, S., Wong, K., Golshahi, L., Brannan, J., Finlay, W., Chan, H. (2017). Examining the ability of empirical correlations to predict subject specific in vivo extrathoracic aerosol deposition during tidal breathing. Aerosol Science and Technology, 51(3), 363-376. [More Information]
Ruzycki, C., Yang, M., Chan, H., Finlay, W. (2017). Improved prediction of intersubject variability in extrathoracic aerosol deposition using algebraic correlations. Aerosol Science and Technology, 51(6), 667-673. [More Information]
Ye, T., Yu, J., Luo, Q., Wang, S., Chan, H. (2017). Inhalable clarithromycin liposomal dry powders using ultrasonic spray freeze drying. Powder Technology, 305, 63-70. [More Information]
Parumasivam, T., Ashhurst, A., Nagalingam, G., Britton, W., Chan, H. (2017). Inhalation of Respirable Crystalline Rifapentine Particles Induces Pulmonary Inflammation. Molecular Pharmaceutics, 14(1), 328-335. [More Information]
Chow, M., Qiu, Y., Lo, F., Lin, H., Chan, H., Kwok, P., Lam, J. (2017). Inhaled powder formulation of naked siRNA using spray drying technology with L-leucine as dispersion enhancer. International Journal of Pharmaceutics, 530(1-2), 40-52. [More Information]
Jahedi, L., Downie, S., Saini, B., Chan, H., Bosnic-Anticevich, S. (2017). Inhaler Technique in Asthma: How Does It Relate to Patients' Preferences and Attitudes Toward Their Inhalers? Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30(1), 42-52. [More Information]
Li, L., Leung, S., Gengenbach, T., Yu, J., Gao, G., Tang, P., Zhou, Q., Chan, H. (2017). Investigation of L-leucine in reducing the moisture-induced deterioration of spray-dried salbutamol sulfate power for inhalation. International Journal of Pharmaceutics, 530(1-2), 30-39. [More Information]
Reslan, M., Demir, Y., Trout, B., Chan, H., Kayser, V. (2017). Lack of a synergistic effect of arginine–glutamic acid on the physical stability of spray-dried bovine serum albumin. Pharmaceutical Development and Technology, 22(6), 785-791. [More Information]
Yang, M., Chan, H. (2017). Monitoring the Inhalation Flow Rate of Nebulized Aerosols Using an Ultrasonic Flow Meter: In Vitro Assessment. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 30(3), 173-181. [More Information]
Tong, Z., Yang, R., Chan, H., Yu, A. (2017). Multiphase Flows in Pharmaceutical Applications. In Guan Heng Yeoh, J. B. Joshi (Eds.), Handbook of Multiphase Flow Science and Technology, (pp. 1-24). Singapore: Springer. [More Information]
Suzuki, H., Hamao, S., Seto, Y., Sato, H., Wong, J., Prud'homme, R., Chan, H., Onoue, S. (2017). New nano-matrix oral formulation of nanoprecipitated cyclosporine A prepared with multi-inlet vortex mixer. International Journal of Pharmaceutics, 516(1-2), 116-119. [More Information]
Saboti, D., Maver, U., Chan, H., Planinsek, O. (2017). Novel Budesonide Particles for Dry Powder Inhalation Prepared Using a Microfluidic Reactor Coupled With Ultrasonic Spray Freeze Drying. Journal of Pharmaceutical Sciences, 106(7), 1881-1888. [More Information]
Lin, Y., Zhou, Q., Cheah, S., Zhao, J., Chen, K., Wang, J., Chan, H., Li, J. (2017). Pharmacokinetics/pharmacodynamics of pulmonary delivery of colistin against Pseudomonas aeruginosa in a mouse lung infection model. Antimicrobial Agents and Chemotherapy, 61(3). [More Information]
Leung, S., Wong, J., Guerra, H., Samnick, K., Prud’homme, R., Chan, H. (2017). Porous mannitol carrier for pulmonary delivery of cyclosporine A nanoparticles. The AAPS Journal, 19(2), 578-586. [More Information]
Ahmed, M., Velkov, T., Lin, Y., Yun, B., Nowell, C., Zhou, F., Zhou, Q., Chan, H., Azad, M., Li, J. (2017). Potential Toxicity of Polymyxins in Human Lung Epithelial Cells. Antimicrobial Agents and Chemotherapy, 61(6), 1-12. [More Information]
Okuda, T., Tang, P., Yu, J., Finlay, W., Chan, H. (2017). Powder aerosol delivery through nasal high-flow system: In vitro feasibility and influence of process conditions. International Journal of Pharmaceutics, 533(1), 187-197. [More Information]
Chang, R., Wong, J., Mathai, A., Morales, S., Kutter, E., Britton, W., Li, J., Chan, H. (2017). Production of highly stable spray dried phage formulations for treatment of Pseudomonas aeruginosa lung infection. European Journal of Pharmaceutics and Biopharmaceutics, 121, 1-13. [More Information]
Leung, S., Parumasivam, T., Gao, G., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Britton, W., Kutter, E., Chan, H. (2017). Production of inhalable bacteriophage dry powders. RDD Europe 2017 Respiratory Drug Delivery, Antibes, France: RDD Europe 2017 Respiratory Drug Delivery.
Yu, J., Chan, H., Gengenbach, T., Denman, J. (2017). Protection of hydrophobic amino acids against moisture-induced deterioration in the aerosolization performance of highly hygroscopic spray-dried powders. European Journal of Pharmaceutics and Biopharmaceutics, 119, 224-234. [More Information]
Lin, Y., Zhou, Q., Hu, Y., Onufrak, N., Sun, S., Wang, J., Forrest, A., Chan, H., Li, J. (2017). Pulmonary Pharmacokinetics of colistin following administration of dry powder aerosols in rats. Antimicrobial Agents and Chemotherapy, 61(11), 1-12. [More Information]
Parumasivam, T., Leung, S., Tang, P., Mauro, C., Britton, W., Chan, H. (2017). The Delivery of High-Dose Dry Powder Antibiotics by a Low-Cost Generic Inhaler. The AAPS Journal, 19(1), 191-202. [More Information]
Lu, X., Chen, L., Wu, C., Chan, H., Freeman, T. (2017). The effects of relative humidity on the flowability and dispersion performance of lactose mixtures. Materials, 10(6), 1-9. [More Information]

show 27 more

2016

Leung, S., Parumasivam, T., Tang, P., Chan, H. (2016). A Proof-of-Principle Setup for Delivery of Relenza (Zanamivir) Inhalation Powder to Intubated Patients. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(1), 30-35. [More Information]
Le,, N., Yu, J., Phan,, H., Neild,, A., Chan, H., Alan,, T. (2016). Acoustic-enhanced 3D T junction for nanodrug crystallization. 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, : Springer Verlag.
Kwok, P., Chan, H. (2016). Advances in Pulmonary Drug Delivery. Boca Raton: CRC Press. [More Information]
Chen, L., Okuda, T., Lu, X., Chan, H. (2016). Amorphous powders for inhalation drug delivery. Advanced Drug Delivery Reviews, 100, 102-115. [More Information]
Leung, S., Chiow, A., Ukkonen, A., Chan, H. (2016). Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs). Pharmaceutical Research, 33(2), 283-291. [More Information]
Kim, S., Burgess, J., Wang, Y., Kable, E., Weiss, D., Chan, H., Chrzanowski, W. (2016). Atomized Human Amniotic Mesenchymal Stromal Cells for Direct Delivery to the Airway for Treatment of Lung Injury. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(6), 514-524. [More Information]
Sato, H., Suzuki, H., Yakushiji, K., Wong, J., Seto, Y., Prud'homme, R., Chan, H., Onoue, S. (2016). Biopharmaceutical Evaluation of Novel Cyclosporine A Nano-matrix Particles for Inhalation. Pharmaceutical Research, 33(9), 2107-2116. [More Information]
Wong, J., Kwok, P., Niemela, V., Heng, D., Crapper, J., Chan, H. (2016). Bipolar electrostatic charge and mass distributions of powder aerosols - Effects of inhaler design and inhaler material. Journal of Aerosol Science, 95, 104-117. [More Information]
Tong, Z., Zhong, W., Yu, A., Chan, H., Yang, R. (2016). CFD-DEM investigation of the effect of agglomerate-agglomerate collision on dry powder aerosolisation. Journal of Aerosol Science, 92, 109-121. [More Information]
Ung, K., Rao, N., Weers, J., Huang, D., Chan, H. (2016). Design of spray dried insulin microparticles to bypass deposition in the extrathoracic region and maximize total lung dose. International Journal of Pharmaceutics, 511(2), 1070-1079. [More Information]
Seto, Y., Suzuki, G., Leung, S., Chan, H., Onoue, S. (2016). Development of an Improved Inhalable Powder Formulation of Pirfenidone by Spray-Drying: In Vitro Characterization and Pharmacokinetic Profiling. Pharmaceutical Research, 33(6), 1447-1455. [More Information]
Parumasivam, T., Chang, R., Abdelghany, S., Ye, T., Britton, W., Chan, H. (2016). Dry powder inhalable formulations for anti-tubercular therapy. Advanced Drug Delivery Reviews, 102, 83-101. [More Information]
Ung, K., Chan, H. (2016). Effects of ramp-up of inspired airflow on in vitro aerosol dose delivery performance for certain dry powder inhalers. European Journal of Pharmaceutical Sciences, 84, 46-54. [More Information]
Wang, W., Zhou, Q., Sun, S., Denman, J., Gengenbach, T., Barraud, N., Rice, S., Li, J., Yang, M., Chan, H. (2016). Effects of Surface Composition on the Aerosolisation and Dissolution of Inhaled Antibiotic Combination Powders Consisting of Colistin and Rifampicin. The AAPS Journal, 18(2), 372-384. [More Information]
Cipolla, D., Wu, H., Salentinig, S., Boyd, B., Rades, T., Vanhecke, D., Fink-Petri, A., Rothin-Rutishauser, B., Eastman, S., Redelmeier, T., Chan, H., et al (2016). Formation of drug nanocrystals under nanoconfinement afforded by liposomes. RSC Advances, 6(8), 6223-6233. [More Information]
Dhanani, J., Fraser, J., Chan, H., Rello, J., Cohen, J., Roberts, J. (2016). Fundamentals of aerosol therapy in critical care. Critical Care, 20(1), 1-16. [More Information]
Zhou, Q., Loh, Z., Yu, J., Sun, S., Gengenbach, T., Denman, J., Li, J., Chan, H. (2016). How Much Surface Coating of Hydrophobic Azithromycin Is Sufficient to Prevent Moisture-Induced Decrease in Aerosolisation of Hygroscopic Amorphous Colistin Powder? The AAPS Journal, 18(5), 1213-1224. [More Information]
Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, H., Li, J., Zhou, F. (2016). Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins. Journal of Antimicrobial Chemotherapy, 71(2), 403-412. [More Information]
Parumasivam, T., Chan, J., Pang, A., Quan, D., Triccas, J., Britton, W., Chan, H. (2016). In Vitro Evaluation of Inhalable Verapamil-Rifapentine Particles for Tuberculosis Therapy. Molecular Pharmaceutics, 13(3), 979-989. [More Information]
Parumasivam, T., Chan, J., Pang, A., Quan, D., Triccas, J., Britton, W., Chan, H. (2016). In vitro evaluation of novel inhalable dry powders consisting of thioridazine and rifapentine for rapid tuberculosis treatment. European Journal of Pharmaceutics and Biopharmaceutics, 107, 205-214. [More Information]
Sugianto, T., Chan, H. (2016). Inhaled antibiotics in the treatment of non-cystic fibrosis bronchiectasis: Clinical and drug delivery perspectives. Expert Opinion on Drug Delivery, 13(1), 7-22. [More Information]
Li, L., Sun, S., Parumasivam, T., Denman, J., Gengenbach, T., Tang, P., Mao, S., Chan, H. (2016). L-Leucine as an excipient against moisture on in vitro aerosolization performances of highly hygroscopic spray-dried powders. European Journal of Pharmaceutics and Biopharmaceutics, 102, 132-141. [More Information]
Leung, S., Parumasivam, T., Gao, G., Carrigy, N., Vehring, R., Finlay, W., Morales, S., Britton, W., Kutter, E., Chan, H. (2016). Production of Inhalation Phage Powders Using Spray Freeze Drying and Spray Drying Techniques for Treatment of Respiratory Infections. Pharmaceutical Research, 33(6), 1486-1496. [More Information]
Zhou, Q., Qu, L., Chan, H. (2016). Pulmonary Delivery of Antibiotics for Respiratory Infections. In Philip Chi Lip Kwok, Hak-Kim Chan (Eds.), Advances in Pulmonary Drug Delivery, (pp. 131-150). Boca Raton: CRC Press. [More Information]
Jin, L., Zhou, Q., Chan, H., Larson, I., Pennington, M., Morales, R., Boyd, B., Norton, R., Nicolazzo, J. (2016). Pulmonary Delivery of the Kv1.3-Blocking Peptide HsTX1[R14A] for the Treatment of Autoimmune Diseases. Journal of Pharmaceutical Sciences, 105(2), 650-656. [More Information]
Leung, S., Parumasivam, T., Tang, P., Chan, H. (2016). Response to Letter to the Editor: Pulmonary Delivery of Dry Powders During Invasive Mechanical Ventilation: Innovations Are Required. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(2), 217-217. [More Information]
Parumasivam, T., Leung, S., Quan, D., Triccas, J., Britton, W., Chan, H. (2016). Rifapentine-loaded PLGA microparticles for tuberculosis inhaled therapy: Preparation and in vitro aerosol characterization. European Journal of Pharmaceutical Sciences, 88, 1-11. [More Information]
Wong, J., Ricci, M., Chan, H. (2016). Spray Drying Strategies to Stop Tuberculosis. In Anthony J. Hickey, Amit Misra, P. Bernard Fourie (Eds.), Drug Delivery Systems for Tuberculosis Prevention and Treatment, (pp. 161-196). New Jersey: John Wiley & Sons. [More Information]
Yang, M., Verschuer, J., Shi, Y., Song, Y., Katsifis, A., Eberl, S., Wong, K., Brannan, J., Cai, W., Finlay, W., Chan, H. (2016). The effect of device resistance and inhalation flow rate on the lung deposition of orally inhaled mannitol dry powder. International Journal of Pharmaceutics, 513(1-2), 294-301. [More Information]
Cipolla, D., Wu, H., Eastman, S., Redelmeier, T., Gonda, I., Chan, H. (2016). Tuning Ciprofloxacin Release Profiles from Liposomally Encapsulated Nanocrystalline Drug. Pharmaceutical Research, 33(11), 2748-2762. [More Information]
Leung, C., Tong, Z., Zhou, Q., Chan, J., Tang, P., Sun, S., Yang, R., Chan, H. (2016). Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-Based DPI Formulations. Part 1: Grid Structure. The AAPS Journal, 18(5), 1159-1167. [More Information]
Chan, H., Tong, Z., Zhou, Q., Leung, C., Yu, A., Yang, R. (2016). Understanding the mechanics of powder dispersion in dry powder inhalers. RDD Asia 2016, Goa, India: Respiratory Drug Delivery Asia 2016.

show 29 more

2015

Lee, S., Teo, J., Heng, D., Zhao, Y., Ng, W., Chan, H., Tan, L., Tan, R. (2015). A novel inhaled multi-pronged attack against respiratory bacteria. European Journal of Pharmaceutical Sciences, 70, 37-44. [More Information]
D'Sa, D., Chan, H. (2015). A Review of Methods for Evaluating Particle Stability in Suspension Based Pressurized Metered Dose Inhalers. Current Pharmaceutical Design, 21(27), 3955-3965. [More Information]
Cipolla, D., Wu, H., Gonda, I., Chan, H. (2015). Aerosol performance and stability of liposomes containing ciprofloxacin nanocrystals. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28(6), 411-422. [More Information]
Tang, P., Leung, S., Hor, E., Ruzycki, C., Carrigy, N., Finlay, W., Brannan, J., Devadason, S., Anderson, S., Sly, P., Samnick, K., Chan, H. (2015). An Apparatus to Deliver Mannitol Powder for Bronchial Provocation in Children Under Six Years Old. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28(6), 452-461. [More Information]
Flynn, S., Tong, Z., Yang, R., Kamiya, H., Yu, A., Chan, H. (2015). Computational fluid dynamics (CFD) investigation of the gas-solid flow and performance of Andersen cascade impactor. Powder Technology, 285, 128-137. [More Information]
Leung, S., Tang, P., Zhou, Q., Tong, Z., Leung, C., Decharaksa, J., Yang, R., Chan, H. (2015). De-agglomeration Effect of the US Pharmacopeia and Alberta Throats on Carrier-Based Powders in Commercial Inhalation Products. The AAPS Journal, 17(6), 1407-1416. [More Information]
Tong, Z., Yu, A., Chan, H., Yang, R. (2015). Discrete Modelling of Powder Dispersion in Dry Powder Inhalers - A Brief Review. Current Pharmaceutical Design, 21(27), 3966-3973. [More Information]
Chan, H., Zhou, Q. (2015). Editorial - Emerging Formulation Design and Drug Delivery Systems for Inhaled Therapy. Current Pharmaceutical Design, 21(27), 3852-3853. [More Information]
Wong, J., Kwok, P., Chan, H. (2015). Electrostatics in pharmaceutical solids. Chemical Engineering Science, 125, 225-237. [More Information]
Kim, S., Naskar, D., Kundu, S., Bishop, D., Doble, P., Boddy, A., Chan, H., Wall, I., Chrzanowski, W. (2015). Formulation of Biologically-Inspired Silk-Based Drug Carriers for Pulmonary Delivery Targeted for Lung Cancer. Scientific Reports, 5, 1-13. [More Information]
Liang, W., Chow, M., Lau, P., Zhou, Q., Kwok, P., Leung, G., Mason, A., Chan, H., Poon, L., Lam, J. (2015). Inhalable Dry Powder Formulations of siRNA and pH-Responsive Peptides with Antiviral Activity Against H1N1 Influenza Virus. Molecular Pharmaceutics, 12(3), 910-921. [More Information]
Velkov, T., Rahim, N., Zhou, Q., Chan, H., Li, J. (2015). Inhaled anti-infective chemotherapy for respiratory tract infections: Successes, challenges and the road ahead. Advanced Drug Delivery Reviews, 85, 65-82. [More Information]
Chan, H., Li, J. (2015). Inhaled antimicrobial chemotherapy for respiratory tract infections: successes, challenges and the road ahead. Advanced Drug Delivery Reviews, 85, v-vii. [More Information]
Zhou, Q., Leung, S., Tang, P., Parumasivam, T., Loh, Z., Chan, H. (2015). Inhaled formulations and pulmonary drug delivery systems for respiratory infections. Advanced Drug Delivery Reviews, 85, 83-89. [More Information]
D'Sa, D., Lechuga-Ballesteros, D., Chan, H. (2015). Isothermal Microcalorimetry of Pressurized Systems II: Effect of Excipient and Water Ingress on Formulation Stability of Amorphous Glycopyrrolate. Pharmaceutical Research, 32(2), 714-722. [More Information]
Wong, J., Lin, Y., Kwok, P., Niemela, V., Crapper, J., Chan, H. (2015). Measuring Bipolar Charge and Mass Distributions of Powder Aerosols by a Novel Tool (BOLAR). Molecular Pharmaceutics, 12(9), 3433-3440. [More Information]
Young, P., Salama, R., Zhu, B., Phillips, G., Crapper, J., Chan, H., Traini, D. (2015). Multi-breath dry powder inhaler for delivery of cohesive powders in the treatment of bronchiectasis. Drug Development and Industrial Pharmacy, 41(5), 859-865. [More Information]
Tong, Z., Kamiya, H., Yu, A., Chan, H., Yang, R. (2015). Multi-Scale Modelling of Powder Dispersion in a Carrier-Based Inhalation System. Pharmaceutical Research, 32(6), 2086-2096. [More Information]
Chan, J., Tyne, A., Pang, A., McLachlan, A., Perera, V., Chan, J., Britton, W., Chan, H., Duke, C., Young, P., Traini, D. (2015). Murine pharmacokinetics of rifapentine delivered as an inhalable dry powder. International Journal of Antimicrobial Agents, 45(3), 319-323. [More Information]
Wang, S., Chen, M., Zhou, Q., Chan, H. (2015). Novel Formulations and Drug Delivery Systems for Phytotherapies. In Not known (Eds.), Phytotherapies: Efficacy, Safety, and Regulation, (pp. 89-100). TBC. [More Information]
Zhou, Q., Sun, S., Chan, J., Wang, P., Barraud, N., Rice, S., Wang, J., Li, J., Chan, H. (2015). Novel Inhaled Combination Powder Containing Amorphous Colistin and Crystalline Rifapentine with Enhanced Antimicrobial Activities against Planktonic Cells and Biofilm of Pseudomonas aeruginosa for Respiratory Infections. Molecular Pharmaceutics, 12(8), 2594-2603. [More Information]
Lin, Y., Wong, J., Qu, L., Chan, H., Zhou, Q. (2015). Powder Production and Particle Engineering for Dry Powder Inhaler Formulations. Current Pharmaceutical Design, 21(27), 3902-3916. [More Information]
Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2015). The Effect of Active Pharmaceutical Ingredients on Aerosol Electrostatic Charges from Pressurized Metered Dose Inhalers. Pharmaceutical Research, 32, 2928-2936. [More Information]
Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2015). The effect of actuator nozzle designs on the electrostatic charge generated in pressurised metered dose inhaler aerosols. Pharmaceutical Research, 32(4), 1237-1248. [More Information]
Kim, S., Wong, A., Neel, E., Chrzanowski, W., Chan, H. (2015). The future perspectives of natural materials for pulmonary drug delivery and lung tissue engineering. Expert Opinion on Drug Delivery, 12(6), 869-887. [More Information]

show 22 more

2014

Chan, J., Duke, C., Ong, H., Chan, J., Tyne, A., Chan, H., Britton, W., Young, P., Traini, D. (2014). A Novel Inhalable Form of Rifapentine. Journal of Pharmaceutical Sciences, 103(5), 1141-1421. [More Information]
Chan, J., Tyne, A., Pang, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2014). A Rifapentine-Containing Inhaled Triple Antibiotic Formulation for Rapid Treatment of Tubercular Infection. Pharmaceutical Research, 31(5), 1239-1253. [More Information]
Chan, J., Wong, J., Zhou, Q., Leung, S., Chan, H. (2014). Advances in Device and Formulation Technologies for Pulmonary Drug Delivery. AAPS PharmSciTech, 15(4), 882-897. [More Information]
Cipolla, D., Wu, H., Gonda, I., Chan, H. (2014). Aerosol Performance and Long-Term Stability of Surfactant-Associated Liposomal Ciprofloxacin Formulations with Modified Encapsulation and Release Properties. AAPS PharmSciTech, 15(5), 1218-1227. [More Information]
Chan, J., Wong, J., Chan, H., Traini, D. (2014). An overview of biosimilars. Journal and Proceedings of the Royal Society of New South Wales, 147(451 and 452), 77-83.
D'Sa, D., Chan, H., Chrzanowski, W. (2014). Attachment of micro- and nano-particles on tipless cantilevers for colloidal probe microscopy. Journal of Colloid and Interface Science, 426, 190-198. [More Information]
Kwok, P., Chan, H. (2014). Delivery of inhalation drugs to children for asthma and other respiratory diseases. Advanced Drug Delivery Reviews, 73, 83-88. [More Information]
Cipolla, D., Wu, H., Eastman, S., Redelmeier, T., Gonda, I., Chan, H. (2014). Development and Characterization of an In Vitro Release Assay for Liposomal Ciprofloxacin for Inhalation. Journal of Pharmaceutical Sciences, 103(1), 314-327. [More Information]
Wong, J., Kwok, P., Noakes, T., Fathi, A., Dehghani, F., Chan, H. (2014). Effect of crystallinity on electrostatic charging in dry powder inhaler formulations. Pharmaceutical Research, 31(7), 1656-1664. [More Information]
Zhou, Q., Tang, P., Leung, S., Chan, J., Chan, H. (2014). Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced Drug Delivery Reviews, 75, 3-17. [More Information]
Liang, W., Kwok, P., Chow, M., Tang, P., Mason, A., Chan, H., Lam, J. (2014). Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 64-73. [More Information]
Ung, K., Rao, N., Weers, J., Clark, A., Chan, H. (2014). In vitro assessment of dose delivery performance of dry powders for inhalation. Aerosol Science and Technology, 48(10), 1099-1110. [More Information]
D'Sa, D., Lechuga-Ballesteros, D., Chan, H. (2014). Isothermal Microcalorimetry of Pressurized Systems I: A Rapid Method to Evaluate Pressurized Metered Dose Inhaler Formulations. Pharmaceutical Research, 31(10), 2716-2723. [More Information]
Cipolla, D., Wu, H., Gonda, I., Eastman, S., Redelmeier, T., Chan, H. (2014). Modifying the release properties of liposomes toward personalized medicine. Journal of Pharmaceutical Sciences, 103(6), 1851-1862. [More Information]
Onoue, S., Yamada, S., Chan, H. (2014). Nanodrugs: pharmacokinetics and safety. International Journal of Nanomedicine, 9(1), 1025-1037. [More Information]
Kwok, P., Chan, H. (2014). Nanotechnology Versus other Techniques in Improving Drug Dissolution. Current Pharmaceutical Design, 20(3), 474-482. [More Information]
Wong, J., D'Sa, D., Foley, M., Chan, J., Chan, H. (2014). NanoXCT: A Novel Technique to Probe the Internal Architecture of Pharmaceutical Particles. Pharmaceutical Research, 31(11), 3085-3094. [More Information]
Young, P., Crapper, J., Gary, P., Sharma, K., Chan, H., Traini, D. (2014). Overcoming Dose Limitations Using the Orbital® Multi-Breath Dry Powder Inhaler. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27(2), 138-147. [More Information]
Dexter, D., Chan, H., Chrzanowski, W. (2014). Predicting Physical Stability in Pressurized Metered Dose Inhalers via Dwell and Instantaneous Force Colloidal Probe Microscopy. European Journal of Pharmaceutics and Biopharmaceutics, 88(1), 129-135. [More Information]
Yang, M., Chan, J., Chan, H. (2014). Pulmonary drug delivery by powder aerosols. Journal of Controlled Release, 193, 228-240. [More Information]
Dexter, D., Chan, H., Kim, H., Chrzanowski, W. (2014). Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy. Journal of Visualized Experiments, 89, 1-9. [More Information]
Wong, J., Chan, H., Chrzanowski, W. (2014). Silk for pharmaceutical and cosmeceutical applications. In S.C Kundu (Eds.), Silk Biomaterials for Tissue Engineering and Regenerative Medicine, (pp. 519-545). Cambridge: Woodhead Publishing Limited. [More Information]
Lee, S., Teo, J., Heng, D., Zhao, Y., Ng, W., Chan, H., Tan, R. (2014). Steroid-decorated antibiotic microparticles for inhaled anti-infective therapy. Journal of Pharmaceutical Sciences, 103(4), 1115-1125. [More Information]
Zhou, Q., Gegenbach, T., Denman, J., Yu, H., Li, J., Chan, H. (2014). Synergistic Antibiotic Combination Powders of Colistin and Rifampicin Provide High Aerosolization Efficiency and Moisture Protection. The AAPS Journal, 16(1), 37-47. [More Information]
Chen, Y., Young, P., Fletcher, D., Chan, H., Long, E., Lewis, D., Church, T., Traini, D. (2014). The Influence of Actuator Materials and Nozzle Designs on Electrostatic Charge of Pressurised Metered Dose Inhaler (pMDI) Formulations. Pharmaceutical Research, 31(5), 1325-1337. [More Information]

show 22 more

2013

Chan, J., Chan, H., Prestidge, C., Denman, J., Young, P., Traini, D. (2013). A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 285-292. [More Information]
Chan, J., Tyne, A., Chan, H., Young, P., Britton, W., Duke, C., Traini, D. (2013). A novel inhaled antibiotic powder to shorten treatment time for latent tuberculosis. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
D'Addio, S., Chan, J., Kwok, P., Benson, B., Prud'homme, R., Chan, H. (2013). Aerosol Delivery of Nanoparticles in Uniform Mannitol Carriers Formulated by Ultrasonic Spray Freeze Drying. Pharmaceutical Research, 30(11), 2891-2901. [More Information]
Zhou, Q., Tong, Z., Tang, P., Yang, R., Chan, H. (2013). CFD analysis of the aerosolization of carrier-based dry powder inhaler formulations. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics. [More Information]
Tong, Z., Zheng, B., Yang, R., Yu, A., Chan, H. (2013). CFD-DEM investigation of the dispersion mechanisms in commercial dry powder inhalers. Powder Technology, 240, 19-24. [More Information]
Zhou, Q., Morton, D., Yu, H., Jacob, J., Wang, J., Li, J., Chan, H. (2013). Colistin Powders with High Aerosolisation Efficiency for Respiratory Infection: Preparation and In Vitro Evaluation. Journal of Pharmaceutical Sciences, 102(10), 3736-3747. [More Information]
Wong, J., Kwok, P., Fathi, A., Dehghani, F., Chan, H. (2013). Crystallinity and electrostatic charge in inhalable salbutamol sulphate powder aerosols. Drug Delivery Australia, DDA 2013.
Wong, J., Kwok, P., Fathi, A., Dehghani, F., Chan, H. (2013). Effect of crystallinity on electrostatic charging in DPI formulations. 2013 Conference of Inhalation Asia, Hong Kong: Inhalation Asia.
Zhou, Q., Tong, Z., Tang, P., Citterio, M., Yang, R., Chan, H. (2013). Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler - A Case Study on Aerolizer® Foradile®. The AAPS Journal, 15(2), 511-522. [More Information]
Adi, S., Adi, H., Chan, H., Tong, Z., Yang, R., Yu, A. (2013). Effects of mechanical impaction on aerosol performance of particles with different surface roughness. Powder Technology, 236, 164-170. [More Information]
Wong, J., Kwok, P., Fathi, A., Dehghani, F., Chan, H. (2013). Electrostatic properties of dry powder inhaler formulations: effect of crystallinity. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Wong, J., Chan, H., Kwok, P. (2013). Electrostatics in pharmaceutical aerosols for inhalation. Therapeutic Delivery, 4(8), 981-1002. [More Information]
Kwek, J., Heng, D., Lee, S., Ng, W., Chan, H., Adi, S., Heng, J., Tan, R. (2013). High speed imaging with electrostatic charge monitoring to track powder deagglomeration upon impact. Journal of Aerosol Science, 65, 77-87. [More Information]
Cipolla, D., Chan, H. (2013). Inhaled antibiotics to treat lung infection. Pharmaceutical Patent Analyst, 2(5), 647-663. [More Information]
Cipolla, D., Gonda, I., Chan, H. (2013). Liposomal formulations for inhalation. Therapeutic Delivery, 4(8), 1047-1072. [More Information]
Heng, D., Lee, S., Ng, W., Chan, H., Kwek, J., Tan, R. (2013). Novel alternatives to reduce powder retention in the dry powder inhaler during aerosolization. International Journal of Pharmaceutics, 452(1-2), 194-200. [More Information]
Chan, H., Kwok, P. (2013). Novel particle production technologies for inhalation products. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 47-62). Chichester, UK: John Wiley & Sons. [More Information]
Kwok, P., Salama, R., Chan, H. (2013). Proteins, peptides, and controlled-release formulations for inhalation. In Paolo Colombo, Daniela Traini, Francesca Buttini (Eds.), Inhalation Drug Delivery: Techniques and Products, (pp. 121-144). Chichester, UK: John Wiley & Sons. [More Information]
Kwok, P., Chan, H. (2013). Pulmonary drug delivery. Therapeutic Delivery, 4(8), 877-878. [More Information]
Guastella, A., Hickie, I., McGuinness, M., Otis, M., Woods, E., Disinger, H., Chan, H., Chen, T., Banati, R. (2013). Recommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research. Psychoneuroendocrinology, 38(5), 612-625. [More Information]
Liang, W., Kwok, P., Chow, M., Mason, A., Chan, H., Lam, J. (2013). Spray and spray freeze dried powders containing pH responsive peptides and mannitol as DNA carriers for pulmonary delivery. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Heng, D., Lee, S., Teo, J., Ng, W., Chan, H., Tan, R. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics. [More Information]
Lee, S., Teo, J., Heng, D., Ng, W., Chan, H., Tan, R. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy: Formulation, characterization and in vitro evaluation. European Journal of Pharmaceutics and Biopharmaceutics, 83(2), 275-284. [More Information]
Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of ethanol on the formation and physico-chemical properties of particles generated from budesonide solution-based pressurized metered-dose inhalers. Drug Development and Industrial Pharmacy, 39(11), 1625-1637. [More Information]
Zhu, B., Traini, D., Chan, H., Young, P. (2013). The effect of glycerol on the formation and morphology of particles generated from budesonide solution-based pressurized metered dose inhalers. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Chen, Y., Traini, D., Fletcher, D., Chan, H., Lewis, D., Church, T., Young, P. (2013). The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. RDD Europe 2013 Respiratory Drug Delivery, Richmond, VA: Virginia Commonwealth University.
Syed Muhammad, S., Oubani, H., Abbas, A., Chan, H., Kwok, P., Dehghani, F. (2013). The production of dry powder by the sonocrystallisation for inhalation drug delivery. Powder Technology, 246, 337-344. [More Information]
Tyne, A., Chan, J., Shanahan, E., Atmosukarto, I., Chan, H., Britton, W., West, N. (2013). TLR2-targeted secreted proteins from Mycobacterium tuberculosis are protective as powdered pulmonary vaccines. Vaccine, 31(40), 4322-4329. [More Information]
Guastella, A., Alvares, G., Hickie, I., Chan, H., Chen, T., Banati, R. (2013). Unitary hormonal models, peripheral markers, and evaluation of response to drug: A response to Weisman and Feldman. Psychoneuroendocrinology, 38, 627-628. [More Information]
Kwek, J., Heng, D., Lee, S., Ng, W., Chan, H., Heng, J., Tan, R. (2013). Visualizing powder de-agglomeration upon impact with simultaneous flowing charge behaviour. 7th International Conference on Micromechanics of Granular Media: Powders and Grains 2013, Melville, New York, USA: American Institute of Physics. [More Information]

show 27 more

2012

De Boer, A., Chan, H., Price, R. (2012). A critical view on lactose-based drug formulation and device studies for dry powder inhalation: Which are relevant and what interactions to expect? Advanced Drug Delivery Reviews, 64(3), 257-274. [More Information]
Chan, J., Chan, H., Young, P., Traini, D. (2012). An Inhaled Triple Antibiotic Dry Powder Formulation for the Treatment of Tuberculosis. Respiratory Drug Delivery (RDD 2012 Arizona), Richmond: Virginia Commonwealth University.
Heng, D., Lee, S., Kwek, J., Ng, W., Chan, H., Tan, R. (2012). Assessing the combinatorial influence of climate, formulation and device on powder aerosolization using the Taguchi experimental design. Powder Technology, 226, 253-260. [More Information]
D'Addio, S., Chan, J., Kwok, P., Prud'homme, R., Chan, H. (2012). Constant size, variable density aerosol particles by ultrasonic spray freeze drying. International Journal of Pharmaceutics, 427(2), 185-191. [More Information]
Chan, J., Traini, D., Chan, H., Young, P., Kwok, P. (2012). Delivery of High Solubility Polyols by Vibrating Mesh Nebulizer to Enhance Mucociliary Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(5), 297-305. [More Information]
Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, H. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807. [More Information]
Faua'ad Sed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). Potential technique for the production of micronised lactose crystals by supercritical fluid conditioning. 10th International Symposium on Supercritical Fluids (ISSF) 2012, San Francisco, USA: Elsevier.
Lam, J., Liang, W., Chan, H. (2012). Pulmonary delivery of therapeutic siRNA. Advanced Drug Delivery Reviews, 64(1), 1-15. [More Information]
Fleming, J., Bailey, D., Chan, H., Conway, J., Kuehl, P., Laube, B., Newman, S. (2012). Standardization of Techniques for Using Single-Photon Emission Computed Tomography (SPECT) for Aerosol Deposition Assessment of Orally Inhaled Products. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(Supplement 1), S-29-S-51. [More Information]
Handayani, D., Meyer, B., Chen, J., Tang, P., Kwok, P., Chan, H., Huang, X. (2012). The comparison of the effect of oat and Shiitake mushroom powder to prevent body weight gain in rats fed high fat diet. Food and Nutrition Sciences, 3(7), 1009-1019. [More Information]
Syed Muhammad, S., Tang, P., Chan, H., Dehghani, F. (2012). The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance. The Journal of Supercritical Fluids, 71, 92-101. [More Information]
Wong, W., Fletcher, D., Traini, D., Chan, H., Young, P. (2012). The use of computational approaches in inhaler development. Advanced Drug Delivery Reviews, 64(4), 312-322. [More Information]
Devadason, S., Chan, H., Haeussermann, S., Kietzig, C., Kuehl, P., Newman, S., Sommerer, K., Taylor, G. (2012). Validation of radiolabeling of drug formulations for aerosol deposition assessment of orally inhaled products. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 25(Supplement 1), S-6-S-9. [More Information]

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2011

Adi, S., Adi, H., Chan, H., Finlay, W., Tong, Z., Yang, R., Yu, A. (2011). Agglomerate strength and dispersion of pharmaceutical powders. Journal of Aerosol Science, 42(4), 285-294. [More Information]
Yamasaki, K., Kwok, P., Fukushige, K., Prud'homme, R., Chan, H. (2011). Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former. International Journal of Pharmaceutics, 420(1), 34-42. [More Information]
Zhang, J., Wu, L., Chan, H., Watanabe, W. (2011). Formation, characterization, and fate of inhaled drug nanoparticles. Advanced Drug Delivery Reviews, 63(6), 441-455. [More Information]
Rojanarat, W., Changsan, N., Tawithong, E., Pinsuwan, S., Chan, H., Srichana, T. (2011). Isoniazid proliposome powders for inhalation-preparation, characterization and cell culture studies. International Journal of Molecular Sciences, 12(7), 4414-4434. [More Information]
Chan, J., Kwok, P., Young, P., Chan, H., Traini, D. (2011). Mannitol Delivery by Vibrating Mesh Nebulisation for Enhancing Mucociliary Clearance. Journal of Pharmaceutical Sciences, 100(7), 2693-2702. [More Information]
Tang, P., Chan, H., Rajbhandari, D., Phipps, P. (2011). Method to Introduce Mannitol Powder to Intubated Patients to Improve Sputum Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24(1), 1-9. [More Information]
Lee, S., Heng, D., Ng, W., Chan, H., Tan, R. (2011). Nano Spray Drying: A Novel Method for Preparing Protein Nanoparticles for Protein Therapy. International Journal of Pharmaceutics, 403(1-2), 192-200. [More Information]
Tong, Z., Adi, S., Yang, R., Chan, H., Yu, A. (2011). Numerical investigation of the de-agglomeration mechanisms of fine powders on mechanical impaction. Journal of Aerosol Science, 42, 811-819. [More Information]
Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-Up in Dry Powder Inhalers: Evaluation and Modelling of Impaction Effects for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(7), 2744-2754. [More Information]
Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2011). Particle Aerosolisation and Break-up in Dry Powder Inhalers: Evaluation and Modelling of the Influence of Grid Structures for Agglomerated Systems. Journal of Pharmaceutical Sciences, 100(11), 4710-4721. [More Information]
Chan, H., Kwok, P. (2011). Production methods for nanodrug particles using the bottom-up approach. Advanced Drug Delivery Reviews, 63(6), 406-416. [More Information]
Kwok, P., Chan, H. (2011). Pulmonary Delivery of Peptides and Proteins. In Chris Van der Walle (Eds.), Peptide and Protein Delivery, (pp. 23-46). London, UK: Academic Press. [More Information]
Chan, J., Chan, H., Kwok, P., Young, P., Traini, D. (2011). Rapid Delivery of Solubilized Mannitol for Treatment of Cystic Fibrosis. Respiratory Drug Delivery Europe (RDD Europe 2011), Illinois, United States: Davis Healthcare International Publishing.

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2010

Syed Muhammad, S., Langrish, T., Tang, P., Adi, H., Chan, H., Kazarian, S., Dehghani, F. (2010). A novel method for the production of crystalline micronised particles. International Journal of Pharmaceutics, 388(1-2), 114-122. [More Information]
Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2010). Agglomerate Strength and Aerosol Performance of API-Only Powders. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
Kumon, M., Kwok, P., Adi, H., Heng, D., Chan, H. (2010). Can low-dose combination products for inhalation be formulated in single crystalline particles? European Journal of Pharmaceutical Sciences, 40(1), 16-24. [More Information]
Adi, H., Young, P., Chan, H., Agus, H., Traini, D. (2010). Co-spray-dried mannitol-ciprofloxacin dry powder inhaler formulation for cystic fibrosis and chronic obstructive pulmonary disease. European Journal of Pharmaceutical Sciences, 40, 239-247. [More Information]
Adi, H., Young, P., Chan, H., Salama, R., Traini, D. (2010). Controlled release antibiotics for dry powder lung delivery. Drug Development and Industrial Pharmacy, 36(1), 119-126. [More Information]
Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2010). Does Impact Angle Affect Powder De-Agglomeration in a Model Throat? RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.
Kwok, P., Trietsch, S., Kumon, M., Chan, H. (2010). Electrostatic Charge Characteristics of Jet Nebulized Aerosols. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(3), 149-159. [More Information]
Kwok, P., Tunsirikongkon, A., Glover, W., Chan, H. (2010). Formation of Protein Nano-Matrix Particles with Controlled Surface Architecture for Respiratory Drug Delivery. Pharmaceutical Research, 28(4), 788-796. [More Information]
Adi, S., Tong, Z., Chan, H., Yang, R., Yu, A. (2010). Impact angles as an alternative way to improve aerosolisation of powders for inhalation? European Journal of Pharmaceutical Sciences, 41(2), 320-327. [More Information]
Tong, Z., Yang, R., Chu, K., Yu, A., Adi, S., Chan, H. (2010). Numerical study of the effects of particle size and polydispersity on the agglomerate dispersion in a cyclonic flow. Chemical Engineering Journal, 164, 432-441. [More Information]
Wong, W., Fletcher, D., Traini, D., Chan, H., Crapper, J., Young, P. (2010). Particle Aerosolisation and Break-up in Dry Powder Inhalers 1: Evaluation and Modelling of Venturi Effects for Agglomerated Systems. Pharmaceutical Research, 27(7), 1367-1376. [More Information]
Cipolla, D., Chan, H., Schuster, J., Farina, D. (2010). Personalizing aerosol medicine: development of delivery systems tailored to the individual. Therapeutic Delivery, 1(5), 667-682. [More Information]
Wong, W., Crapper, J., Chan, H., Traini, D., Young, P. (2010). Pharmacopeial methodologies for determining aerodynamic mass distributions of ultra-high dose inhaler medicines. Journal of Pharmaceutical and Biomedical Analysis, 51(4), 853-857. [More Information]
Weers, J., Bell, J., Chan, H., Cipolla, D., Dunbar, C., Hickey, A., Smith, I. (2010). Pulmonary Formulations: What Remains to be Done? Journal of Aerosol Medicine and Pulmonary Drug Delivery, 23(2), S5-S23. [More Information]
Hoe, S., Traini, D., Chan, H., Young, P. (2010). The Contribution of Different Formulation Components on the Aerosol Charge in Carrier-Based Dry Powder Inhaler Systems. Pharmaceutical Research, 27(7), 1325-1336. [More Information]
Wong, W., Adi, H., Traini, D., Chan, H., Fletcher, D., Crapper, J., Young, P. (2010). Use of Rapid Prototyping and Computational Fluid Dynamics in the Design of DPI Devices. RDD 2010 Florida Respiratory Drug Delivery, United States: Davis Healthcare International Publishing.

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2009

Syed Muhammad, S., Langrish, T., Chan, H., Tang, P., Dehghani, F. (2009). A new method for he production of crystalline microparticle. 9th International Symposium on Supercritical Fluids (ISSF) 2009, Arcachon, France.
Kwok, P., Glover, W., Chan, H. (2009). Aerosol Performance of Bovine Serum Albumin Nano-matrices for Inhalation. Asian Federation for Pharmaceutical Sciences (AFPS) 2009 Conference, Japan: Kumamoto University.
Hoe, S., Young, P., Chan, H., Traini, D. (2009). Application of the Electrical Next Generation Impactor (eNGI) for the Electrostatic Characterization of Commercial Dry Powder Inhaler Formulations. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
Tang, P., Chan, H., Chiou, H., Ogawa, K., Jones, M., Adi, H., Buckton, G., Prud'homme, R., Raper, J. (2009). Characterisation and aerosolisation of mannitol particles produced via confined liquid impinging jets. International Journal of Pharmaceutics, 367, 51-57. [More Information]
Coates, M., Tang, P., Chan, H., Fletcher, D., Raper, J. (2009). Characterization of pharmaceutical aerosols and dry powder inhalers for pulmonary drug delivery. In Sigmund W, El-Shall H, Shah D, Moudgil B (Eds.), Particulate Systems in Nano and Biotechnologies, (pp. 193-222). Boca Raton, USA: CRC Press. [More Information]
Salama, R., Ladd, L., Chan, H., Traini, D., Young, P. (2009). Development of an In Vivo Ovine Dry Powder Inhalation Model for the Evaluation of Conventional and Controlled Release Microparticles. The AAPS Journal, 11(3), 465-468. [More Information]
Adi, H., Kwok, P., Crapper, J., Young, P., Traini, D., Chan, H. (2009). Does Electrostatic Charge Affect Powder Aerosolisation? Journal of Pharmaceutical Sciences, 99 (May 2010)(5), 1-8. [More Information]
Kwok, P., Chan, H. (2009). Electrostatics of pharmaceutical inhalation aerosols. Journal of Pharmacy and Pharmacology, 61(12), 1587-1599. [More Information]
Wong, W., Traini, D., Chan, H., Crapper, J., Young, P. (2009). High Dose Respiratory Medicines: Pharmacopeia Methodologies for Determining Aerodynamic Mass Distributions. RDD Europe 2009 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
Hoe, S., Young, P., Chan, H., Traini, D. (2009). Introduction of the Electrical Next Generation Impactor (eNGI) and Investigation of its Capabilities for the Study of Pressurized Metered Dose Inhalers. Pharmaceutical Research, 26(2), 431-437. [More Information]
Heng, D., Ogawa, K., Cutler, D., Chan, H., Raper, J., Ye, L., Yun, J. (2009). Investigating the Unique Dissolution Behaviour of Nanoparticles. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Young, P., Kwok, P., Adi, H., Chan, H., Traini, D. (2009). Lactose Composite Carriers for Respiratory Delivery. Pharmaceutical Research, 26(4), 802-810. [More Information]
Hoe, S., Traini, D., Chan, H., Young, P. (2009). Measuring charge and mass distributions in dry powder inhalers using the electrical Next Generation Impactor (eNGI). European Journal of Pharmaceutical Sciences, 38, 88-94. [More Information]
Tong, Z., Yang, R., Yu, A., Adi, S., Chan, H. (2009). Numerical modelling of the breakage of loose agglomerates of fine particles. Powder Technology, 196(2), 213-221. [More Information]
Changsan, N., Chan, H., Separovic, F., Srichana, T. (2009). Physicochemical Characterization and Stability of Rifampicin Liposome Dry Powder Formulations for Inhalation. Journal of Pharmaceutical Sciences, 98(2), 628-639. [More Information]
Tang, P., Chan, H., Raper, J. (2009). Prediction of Aerodynamic Diameter of Particles with Corrugated Surface. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Salama, R., Traini, D., Chan, H., Sung, M., Ammit, A., Young, P. (2009). Preparation and Evaluation of Controlled Release Microparticles for Respiratory Protein Therapy. Journal of Pharmaceutical Sciences, 98(8), 2709-2717. [More Information]
Kwok, P., Adi, H., Chan, H. (2009). Protein Nano-Matrices with Controlled Surface Roughness for Inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Heng, D., Ogawa, K., Cutler, D., Chan, H., Raper, J., Ye, L., Yun, J. (2009). Pure drug nanoparticles in tablets: what are the dissolution limitations? Journal of Nanoparticle Research, 12(5), 1743-1754. [More Information]
Salama, R., Traini, D., Chan, H., Young, P. (2009). Recent Advances in Controlled Release Pulmonary Therapy. Current Drug Delivery, 6(4), 404-414. [More Information]
Adi, H., Wong, W., Kwok, P., Traini, D., Young, P., Chan, H. (2009). Surface energy contribution of container materials to the triboelectric charging of pharmaceutical powder for inhalation. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Adi, S., Adi, H., Chan, H., Yang, R., Yu, A., Tong, Z. (2009). The Importance of Agglomerate Strength on the Aerosol Performance of Pharmaceutical Dry Powders. 6th International Conference for Conveying and Handling of Particulate Solids (CHoPS+ICBMH), Barton, ACT Australia: Engineers Australia.
Hoe, S., Traini, D., Chan, H., Young, P. (2009). The Influence of Flow Rate on the Aerosol Deposition Profile and Electrostatic Charge of Single and Combination Metered Dose Inhalers. Pharmaceutical Research, 26(12), 2639-2646. [More Information]
Tang, P., Chan, H., Raper, J. (2009). Validation of computation method to predict aerodynamic diameter of particles with rough surface. Powder Technology, 192(1), 74-84. [More Information]

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2008

Chiou, H., Chan, H., Heng, D., Prud'homme, R., Raper, J. (2008). A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation. Journal of Aerosol Science, 39(6), 500-509. [More Information]
Yang, R., Yu, A., Choi, S., Coates, M., Chan, H. (2008). Agglomeration of fine particles subjected to centripetal compaction. Powder Technology, 184(1), 122-129. [More Information]
Young, P., Roberts, D., Chiou, H., Rae, W., Chan, H., Traini, D. (2008). Composite carriers improve the aerosolisation efficiency of drugs for respiratory delivery. Journal of Aerosol Science, 39, 82-93. [More Information]
Heng, D., Cutler, D., Chan, H., Yun, J., Raper, J. (2008). Dissolution kinetic behavior of drug nanoparticles and their conformity to the diffusion model. Langmuir, 24(14), 7538-7544. [More Information]
Kwok, P., Noakes, T., Chan, H. (2008). Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 39(3), 211-226. [More Information]
Glover, W., Chan, H., Eberl, S., Daviskas, E., Verschuer, J. (2008). Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers. International Journal of Pharmaceutics, 349(1/2), 314-322. [More Information]
Kwok, P., Chan, H. (2008). Effect of Relative Humidity on the Electrostatic Charge Properties of Dry Powder Inhaler Aerosols. Pharmaceutical Research, 25(2), 277-288. [More Information]
Hoe, S., Young, P., Chan, H., Traini, D. (2008). Electrical Next Generation Impactor (eNGI): A New Method for Aerosol Electrostatics. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Chiou, H., Chan, H., Prud'homme, R., Raper, J. (2008). Evaluation on the use of confined liquid impinging jets for the synthesis of nanodrug particles. Drug Development and Industrial Pharmacy, 34(1), 59-64. [More Information]
Chan, H. (2008). Formulation challenges: protein powders for inhalation. In MJ Rathbone, J Hadgraft, MS Roberts, ME Lane (Eds.), Modified Release Drug Delivery Technology, (pp. 623-636). NY, New York: Informa Healthcare. [More Information]
Salama, R., Ladd, L., Traini, D., Chan, H., Young, P. (2008). Formulation, Characterization and In Vitro - In Vivo Evaluation of Spray Dried Pulmonary Microparticles in an Ovine Animal Model. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Chan, H., Gonda, I., Shire, S., Weck, S. (2008). Improved DNase liquid solution. Patent No. CA-2184581-A1, JP-3009224-B2. , Canada.
Chan, H., Gonda, I., Shire, S., Weck, S. (2008). Improved DNase liquid solutions. Patent No. EP 0 748 377 B1.
Newman, S., Chan, H. (2008). In vitro/in vivo comparisons in pulmonary drug delivery. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 21(1), 77-84. [More Information]
Adi, S., Adi, H., Tang, P., Traini, D., Chan, H., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information]
Salama, R., Hoe, S., Chan, H., Traini, D., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics. European Journal of Pharmaceutics and Biopharmaceutics, 69(2), 486-495. [More Information]
Salama, R., Traini, D., Chan, H., Young, P. (2008). Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: Evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. European Journal of Pharmaceutics and Biopharmaceutics, 70(1), 145-152. [More Information]
Hu, T., Chiou, H., Chan, H., Chen, J., Yun, J. (2008). Preparation of inhalable salbutamol sulphate using reactive high gravity controlled precipitation. Journal of Pharmaceutical Sciences, 97(2), 944-949. [More Information]
Adi, S., Adi, H., Chan, H., Young, P., Traini, D., Yang, R., Yu, A. (2008). Scanning white-light interferometry as a novel technique to quantify the surface roughness of micron-sized particles for inhalation. Langmuir, 24(19), 11307-11312. [More Information]
Tang, P., Fletcher, D., Chan, H., Raper, J. (2008). Simple and cost-effective powder disperser for aerosol particle size measurement. Powder Technology, 187(1), 27-36. [More Information]
Kwok, P., Chan, H. (2008). Solid Forms and Electrostatic Properties of Salbutamol Sulfate. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Adi, S., Adi, H., Chan, H., Young, P., Traini, D. (2008). Use of Scanning White Light Interferometry to Evaluate the Surface Roughness and Aerosol Performance of Spherical Micron-Sized Drug Particles. Respiratory Drug Delivery 2008, River Grove, Illinois, USA: Davis Healthcare International Publishing.
Heng, D., Cutler, D., Chan, H., Yun, J., Raper, J. (2008). What is a suitable dissolution method for drug nanoparticles? Pharmaceutical Research, 25(7), 1696-1701. [More Information]
Chan, H. (2008). What is the role of particle morphology in pharmaceutical powder aerosols? Expert Opinion on Drug Delivery, 5(8), 909-914. [More Information]

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2007

Adi, H., Young, P., Chan, H., Traini, D., Stewart, P. (2007). Cospray dried antibiotics for dry powder inhalation delivery. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing. [More Information]
Adi, H., Young, P., Chan, H., Stewart, P., Agus, H., Traini, D. (2007). Cospray dried antibiotics for dry powder lung delivery. Journal of Pharmaceutical Sciences, online(DOI 10.1002/jps.21239), 1-11. [More Information]
Chan, H., Young, P., Traini, D., Coates, M. (2007). Dry powder inhalers: challenges and goals for next generation therapies. Pharmaceutical Technology Europe, 19(4), 19-24.
Kwok, P., Chan, H. (2007). Electrostatic Charge in Pharmaceutical Systems. In James Swarbrick and James C. Boylan (Eds.), Encyclopedia of Pharmaceutical Technology, (pp. 1535-1547). New York, USA: Marcel Dekker.
Heng, D., Tang, P., Cairney, J., Chan, H., Cutler, D., Salama, R., Yun, J. (2007). Focused-ion-beam Milling: A Novel Approach to Probing the Interior of Particles Used for Inhalation Aerosols. Pharmaceutical Research, 24(9), 1608-1617. [More Information]
Mitchell, J., Newman, S., Chan, H. (2007). In Vitro and In Vivo Aspects of Cascade Impactor Tests and Inhaler Performance: A Review. AAPS PharmSciTech, 8(4), 110-E1-110-E12.
Young, P., Sung, M., Traini, D., Kwok, P., Chiou, H., Chan, H. (2007). Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems. Pharmaceutical Research, 24(5), 963-970. [More Information]
Coates, M., Chan, H., Fletcher, D., Chiou, H. (2007). Influence of Mouthpiece Geometry on the Aerosol Delivery Performance of a Dry Powder Inhaler. Pharmaceutical Research, 24(8), 1450-1456. [More Information]
Chiou, H., Glover, W., Jun, H., Chan, H., Yun, J. (2007). Metered Dose Inhaler Performance Of High-Gravity Controlled Precipitated Salbutamol Sulfate. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
Chiou, H., Li, L., Hu, T., Chan, H., Chen, J., Yun, J. (2007). Production of salbutamol sulfate for inhalation by high-gravity controlled antisolvent precipitation. International Journal of Pharmaceutics, 331(1), 93-98. [More Information]
Young, P., Traini, D., Coates, M., Chan, H. (2007). Recent advances in understanding the influence of composite-formulation properties on the performance of dry powder inhalers. Physica B: Condensed Matter, 394(2), 315-319. [More Information]
Jouyban, A., Soltanpour, S., Soltani, S., Chan, H., Acree, W. (2007). Solubility prediction of drugs in water-cosolvent mixtures using Abraham solvation parameters. Journal of Pharmacy and Pharmaceutical Sciences, 10(3), 263-277. [More Information]
Abbas, A., Srour, M., Tang, P., Chiou, H., Chan, H., Romagnoli, J. (2007). Sonocrystallization of sodium chloride particles for inhalation. Chemical Engineering Science, 62(9), 2445-2453. [More Information]
Adi, H., Traini, D., Chan, H., Young, P. (2007). The influence of drug morphology on the aerosolisation efficiency of dry powder inhaler formulations. Journal of Pharmaceutical Sciences, Published online DOI 10.1002/jps.21195(Print version 2008 VOL. 97, NO. 7), 2780-2788. [More Information]
Young, P., Chan, H., Chiou, H., Edge, S., Tee, H., Traini, D. (2007). The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance. Journal of Pharmaceutical Sciences, 96(5), 1331-1341. [More Information]
Chan, H. (2007). The Role Of Particle Morphology In Powder Inhalers. RDD Europe 2007 Respiratory Drug Delivery, Illinois, USA: Davis Healthcare International Publishing.
Young, P., Chiou, H., Tee, H., Traini, D., Chan, H., Thielmann, F., Burnett, D. (2007). The use of organic vapor sorption to determine low levels of amorphous content in processed pharmaceutical powders. Drug Development and Industrial Pharmacy, 33(1), 91-97. [More Information]

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2006

Goodall, S., Waters, M., Mahler, S., Chan, H., Chew, N. (2006). Compositions for protein delivery via the pulmonary route. Patent No. EP 1 389 137 B1.
Chan, H., Gonda, I., Shire, S., Weck, S. (2006). DNase liquid solutions. Patent No. 7,018,825 B2.
Chan, H. (2006). Dry powder aerosol delivery systems: current and future research directions. Journal of Aerosol Medicine, 19(1), 21-27. [More Information]
Chan, H. (2006). Dry powder aerosol drug delivery-Opportunities for colloid and surface scientists. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 284-285, 50-55. [More Information]
Coates, M., Chan, H., Fletcher, D., Raper, J. (2006). Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 2: Air inlet size. Journal of Pharmaceutical Sciences, 95(6), 1382-1392. [More Information]
Kwok, P., Collins, R., Chan, H. (2006). Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols. Journal of Aerosol Science, 37(12), 1671-1682. [More Information]
Kwok, P., Chan, H. (2006). Electrostatic charges of metered dose inhaler aerosols sampled from plastic spacers. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Young, P., Chan, H., Kwok, P., Chiou, H., Sung, M., Traini, D. (2006). Influence of humidity and static charge on dry powder inhaler aerosolisation: carrier based systems. AAPS Annual Meeting and Exposition, United States: American Association of Pharmaceutical Scientists.
Coates, M., Chan, H., Fletcher, D. (2006). Influence of mouthpiece geometry on the performance of a dry powder inhaler. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Chan, H., Chiou, H., Chen, J., Hu, T., Yun, J. (2006). Inhalable Drug. Patent No. 2006096906. World.
Glover, W., Chan, H., Eberl, S., Daviskas, E., Anderson, S. (2006). Lung Deposition of Mannitol Powder Aerosol in Healthy Subjects. Journal of Aerosol Medicine, 19(4), 522-532. [More Information]
Jouyban, A., Khoubnasabjafari, M., Chan, H., Acree, W. (2006). Mathematical representation of solubility of amino acids in binary aqueous-organic solvent mixtures at various temperatures using the Jouyban-Acree model. Die Pharmazie: an international journal of pharmaceutical sciences, 61(9), 789-792.
Young, P., Salama, R., Chan, H., Traini, D. (2006). Preparation and characterisation of controlled release microparticles for inhalation. Australasian Pharmaceutical Science Association (APSA).
Tang, P., Chan, H., Tam, E., de Gruyter, N., Chan, J. (2006). Preparation of NaCl powder suitable for inhalation. Industrial and Engineering Chemistry Research, 45(12), 4188-4192. [More Information]
Chiou, H., Li, L., Chan, H., Hu, T., Chen, R., Yun, J. (2006). Production of salbutamol sulfate powders using high gravity controlled precipitation. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Jouyban, A., Chan, H., Chew, N., Khoubnasabjafari, M., Acree, W. (2006). Solubility Prediction of Paracetamol in Binary and Ternary Solvent Mixtures Using Jouyban-Acree Model. Chemical and Pharmaceutical Bulletin, 54(4), 428-431. [More Information]
Jouyban, G., Chew, N., Chan, H., Khoubnasabjafari, M., Acree, W. (2006). Solubility prediction of salicylic acid in water-ethanol-propylene glycol mixtures using the Jouyban-Acree model. Die Pharmazie: an international journal of pharmaceutical sciences, 61(4), 318-321. [More Information]
Eberl, S., Chan, H., Daviskas, E. (2006). SPECT Imaging for Radioaerosol Deposition and Clearance Studies. Journal of Aerosol Medicine, 19(1), 8-20. [More Information]
Li, L., Chiou, H., Heng, D., Chan, H., Prud'homme, R., Raper, J. (2006). Studies on nano-pharmaceuticals formulated using confined impinging jets for pulmonary drug delivery. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Issa, F., Kassiou, M., Chan, H., McLeod, M. (2006). Synthesis and radiolabelling of ipratropium and tiotropium for use as PET ligands in the study of inhaled drug deposition. Australian Journal of Chemistry, 59(1), 53-58. [More Information]
Chan, H., Foster, N., Regtop, H., Dehghani, F., Bustami, R. (2006). Synthesis Of Small Particles. Patent No. 2002221320.
Chan, H., Chiou, H., Kwok, P. (2006). The 15th International Society of Aerosols in Medicine Congress. Perth, Australia, 14-18 March 2005. Expert Opinion on Drug Delivery, 3(1), 163-167. [More Information]
Traini, D., Tee, H., Chiou, H., Chan, H., Young, P. (2006). The Effect of Mechanically Processed Pharmaceutical Carries for Dry Powder Inhalation on Drug Aerosolisation Performance. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Glover, W., Chan, H., Eberl, S., Daviskas, E., Verschuer, J. (2006). The Effect of Particle Size of A Powder Dry Aerosol On Lung Deposition. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.
Tang, P., Chan, H., Raper, J. (2006). Validation of Computation Method to Predict Aerodynamic Diameter of Particles with Rough Surface. Respiratory Drug Delivery 2006, River Grove, Illinois 60171, United States: Davis Healthcare International Publishing.

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2005

Jouyban, A., Chew, N., Chan, H., Sabour, M., Acree, W. (2005). A Unified Cosolvency Model for Calculating Solute Solubility in Mixed Solvents. Chemical and Pharmaceutical Bulletin, 53(6), 634-637. [More Information]
Koskela, H., Martens, R., Brannan, J., Anderson, S., Leuppi, J., Chan, H. (2005). Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. Respirology, 10, 442-448. [More Information]
Chew, N., Shekunov, B., Tong, H., Chow, A., Savage, C., Wu, J., Chan, H. (2005). Effect of amino acids on the dispersion of disodium cromoglycate powders. Journal of Pharmaceutical Sciences, 94(10), 2289-2300. [More Information]
Kwok, P., Glover, W., Chan, H. (2005). Electrostatic charge characteristics of aerosols produced from metered dose inhalers. Journal of Pharmaceutical Sciences, 94(12), 2789-2799. [More Information]
Chew, N., Tang, P., Chan, H., Raper, J. (2005). How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharmaceutical Research, 22(1), 148-152. [More Information]
Coates, M., Chan, H., Fletcher, D., Raper, J. (2005). Influence of air flow on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research, 22(9), 1445-1453. [More Information]
Daviskas, E., Anderson, S., Gomes, K., Briffa, P., Cochrane, B., Chan, H., Young, I., Rubin, B. (2005). Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputum. Respirology, 10(1), 46-56. [More Information]
Jouyban, A., Soltani, S., Chan, H., Acree, W. (2005). Modeling acid dissociation constant of analytes in binary solvents at various temperatures using Jouyban-Acree model. Thermochimica acta, 428, 119-123. [More Information]
Jouyban, A., Khoubnasabjafari, M., Chan, H. (2005). Modeling the entrainer effects on solubility of solutes in supercritical carbon dioxide. Chemical and Pharmaceutical Bulletin, 53(3), 290-295. [More Information]
Leuppi, J., Tandjung, R., Anderson, S., Stolz, D., Brutsche, M., Bingisser, R., Perruchoud, A., Surber, C., Knoblauch, A., Andersson, M., Chan, H., et al (2005). Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept. Pulmonary Pharmacology and Therapeutics, 18(2), 83-88. [More Information]
Coates, M., Fletcher, D., Chan, H., Raper, J. (2005). The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses. Pharmaceutical Research, 22(6), 923-932. [More Information]

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2004

Jouyban, A., Soltanpour, S., Chan, H. (2004). A Simple Relationship Between Dielectric Constant Of Mixed Solvents With Solvent Composition And Temperature. International Journal of Pharmaceutics, 269(2), 353-360. [More Information]
Koskela, H., Hyvarinen, L., Brannan, J., Chan, H., Anderson, S. (2004). Coughing During Mannitol Challenge Is Associated With Asthma. Chest, 125(6), 1985-1992. [More Information]
Coates, M., Fletcher, D., Chan, H., Raper, J. (2004). Effect Of Design On The Performance Of A Dry Powder Inhaler Using Computational Fluid Dynamics. Part 1: Grid Structure And Mouthpiece Length. Journal of Pharmaceutical Sciences, 93(11), 2863-2876. [More Information]
Chew, N., Reddel, H., Bosnic-Anticevich, S., Chan, H. (2004). Effect Of Mouthpiece Washing On Aerosol Performance Of Cfc-Free Ventolin. Journal of Asthma, 41(7), 721-727. [More Information]
Glover, W., Chan, H. (2004). Electrostatic Charge Characterization Of Pharmaceutical Aerosols Using Electrical Low-Pressure Impaction (Elpi). Journal of Aerosol Science, 35(6), 755-764. [More Information]
Chen, J., Zhou, M., Shao, L., Wang, Y., Yun, J., Chew, N., Chan, H. (2004). Feasibility Of Preparing Nanodrugs By High-Gravity Reactive Precipitation. International Journal of Pharmaceutics, 269(1), 267-274. [More Information]
Tang, P., Chan, H., Raper, J. (2004). Fractal Geometry In Pharmaceutical And Biological Applications - A Review. In James Swarbrick (Eds.), Encyclopaedia of Pharmaceutical Technology, (pp. 1779-1806). New York (on-line): Informa Healthcare.
Chan, H., Clark, A., Gonda, I., Hsu, C., Mumenthaler, M., Shire, S. (2004). Pharmaceutically acceptable DNase formulation. Patent No. EP 0748225 B1.
Chan, H., Clark, A., Feeley, J., Kuo, M., Lehrman, S., Pikal-Cleland, K., Miller, D., Vehring, R., Lechuga-Ballesteros, D. (2004). Physical Stability Of Salmon Calcitonin Spray-Dried Powders For Inhalation. Journal of Pharmaceutical Sciences, 93(3), 792-804. [More Information]
Tang, P., Chan, H., Raper, J. (2004). Prediction Of Aerodynamic Diameter Of Particles With Rough Surfaces. Powder Technology, 147(1-3), 64-78. [More Information]
Jouyban, G., Chan, H., Romero, S., Khoubnasabjafari, M., Bustamante, P. (2004). Solubility prediction in water-ethanol mixtures based on the excess free energy approach using a minimum number of experimental data. Die Pharmazie: an international journal of pharmaceutical sciences, 59(2), 117-120.

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2003

Jouyban, A., Jabbaribar, F., Chan, H. (2003). An improved empirical model to calculate solute solubility in supercritical carbon dioxide. Die Pharmazie: an international journal of pharmaceutical sciences, 58(6), 396-398.
Jouyban, A., Chan, H., Khoubnasabjafari, M., Clark, B. (2003). Calculation of electrophoretic mobility in ternary solvent electrolyte systems. Journal of Pharmaceutical and Biomedical Analysis, 32(2), 203-208. [More Information]
Jouyban, A., Chan, H., Clark, B., Kenndler, E. (2003). Comparison of different algorithms to calculate electrophoretic mobility of analytes as a function of binary solvent composition. Electrophoresis, 24(10), 1596-1602. [More Information]
Waters, M., Mahler, S., Chan, H., Goodall, S., Chew, N. (2003). Compositions for protein delivery via the pulmonary route. Patent No. US 2003/0064052 A1.
Chan, H. (2003). Formulation challenges: Protein powders for inhalation. In Rathbone, Hadgraft, Roberts (Eds.), Modified-Release Drug Delivery Technology, Vol. 126, (pp. 879-890). United States: Marcel Dekker.
Bustami, R., Chan, H., Sweeney, T., Dehghani, F., Foster, N. (2003). Generation of Fine Powders of Recombinant Human Deoxyribonuclease Using the Aerosol Solvent Extraction System. Pharmaceutical Research, 20(12), 2028-2035. [More Information]
Koskela, H., Taivainen, A., Tukiainen, H., Chan, H. (2003). Inhalation Challenge with Bovine Dander Allergens: Who Needs It? Chest, 124(1), 383-391. [More Information]
Chan, H. (2003). Inhalation drug delivery devices and emerging technologies. Expert Opinion on Therapeutic Patents, 13(9), 1333-1343. [More Information]
Tang, P., Chew, N., Chan, H., Raper, J. (2003). Limitation of Determination of Surface Fractal Dimension Using N2 Adsorption Isotherms and Modified Frenkel-Halsey-Hill Theory. Langmuir, 19(7), 2632-2638. [More Information]
Holzer, K., Anderson, S., Chan, H., Douglass, J. (2003). Mannitol as a Challenge Test to Identify Exercise-induced Bronchoconstriction in Elite Athletes. American Journal of Respiratory and Critical Care Medicine, 167(4), 534-537. [More Information]
Jouyban, A., Grosse, S., Chan, H., Coleman, M., Clark, B. (2003). Mathematical representation of electrophoretic mobility of basic drugs in ternary solvent buffers in capillary zone electrophoresis. Journal of Chromatography A, 994(1-2), 191-198. [More Information]
Chan, H., Chew, N. (2003). Novel alternative methods for the delivery of drugs for the treatment of asthma. Advanced Drug Delivery Reviews, 55(7), 793-805. [More Information]
Jouyban, A., Khoubnasabjafari, M., Chan, H., Altria, K., Clark, B. (2003). Predicting Electrophoretic Mobility of Beta-blockers in a Water-Methanol Based Electrolyte System. Chromatographia, 57(3-4), 191-195. [More Information]
Koskela, H., Hyraerinen, L., Brannan, J., Chan, H., Anderson, S. (2003). Responsiveness to Three Bronchial Provocation Tests in Patients with Asthma. Chest, 124(6), 2171-2177. [More Information]
Koskela, H., Hyraerinen, L., Brannan, J., Chan, H., Anderson, S. (2003). Sensitivity and Validity of Three Bronchial Provocation Tests to Demonstrate the Effect of Inhaled Corticosteroids in Asthma. Chest, 124(4), 1341-1349. [More Information]

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2002

Jouyban, A., Romero, S., Chan, H., Clark, B., Bustamante, P. (2002). A cosolvency model to predict solubility of drugs at several temperatures from a limited number of solubility measurements. Chemical and Pharmaceutical Bulletin, 50(5), 594-599. [More Information]
Jouyban, A., Chan, H., Barzegar-Jalali, M., Acree, W. (2002). A model to represent solvent effects on the chemical stability of solutes in mixed solvent systems. International Journal of Pharmaceutics, 243(1-2), 167-172. [More Information]
Lam, Y., Bustami, R., Phan, T., Chan, H., Seoarivuc, F. (2002). A solid-state NMR study of protein mobility in lyophilized protein-sugar powders. Journal of Pharmaceutical Sciences, 91(4), 943-951. [More Information]
Goodall, S., Chew, N., Chan, H., Auriac, D., Waters, M. (2002). Aerosolization of protein solutions using thermal inkjet technology. Journal of Aerosol Medicine, 15(3), 351-357. [More Information]
Brennan, J., Koskela, H., Anderson, S., Chan, H. (2002). Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology, 7(1), 37-44. [More Information]
Jouyban, A., Grosse, S., Coleman, M., Chan, H., Kenndler, E., Clark, B. (2002). Calculation of electrophoretic mobility in mixed solvent buffers in capillary zone electrophoresis using a mixture response surface method. Analyst, 127(9), 1118-1192. [More Information]
Chan, H., Eberl, S., Daviskas, E., Constable, C., Young, I. (2002). Changes in lung deposition of aerosols due to hygroscopic growth: a fast SPECT study. Journal of Aerosol Medicine, 15(3), 307-311. [More Information]
Chew, N., Chan, H., Bagster, D., Mukharaiya, J. (2002). Characterization of pharmaceutical powder inhalers: estimation of energy input for powder dispersion and effect of capsule device configuration. Journal of Aerosol Science, 33(7), 999-1008. [More Information]
Chew, N., Chan, H. (2002). Effect of powder polydispersity on aerosol generation. Journal of Pharmacy and Pharmaceutical Sciences, 5(2), 162-168.
Daviskas, E., Anderson, S., Eberl, S., Chan, H., Young, I., Seale, J. (2002). Effects of terbutaline in combination with mannitol on mucociliary clearance. European Respiratory Journal, 20, 1423-1429. [More Information]
Tang, P., Chan, H., Schneider, C. (2002). Impact of timing valve on the invitro particle size distribution of the Bricanyl Turhuhalerï¿½. Pharmaceutical Science beyond the Genome: Harnessing the Potential, : British Medical Journal Publishing Group.
Jouyban, A., Chan, H., Clark, B., Acree, W. (2002). Mathematical representation of apparent dissociation constants in aqueous -organic solvent mixtures. International Journal of Pharmaceutics, 246(1-2), 135-142. [More Information]
Jouyban, A., Chan, H., Foster, N. (2002). Mathematical representation of solute solubility in supercritical carbon dioxide using empirical expressions. The Journal of Supercritical Fluids, 24(1), 19-35. [More Information]
Chan, H., Gonda, I., Shire, S., Weck, S. (2002). Minimizing thermally induced aggregation of DNase in solution with calcium. Patent No. 6,383,788 B1.
Chew, N., Bosnic-Anticevich, S., Reddel, H., Chan, H., Collis,, L. (2002). Salbutamol sulphate CFC-free metered dose inhalers: effects of washing the inhaler mouthpiece on aerosol performance and potential consequences. TSANZ Annual Scientific Meeting.
Jouyban, A., Rehman, M., Shekunov, B., Chan, H., Clark, B., York, P. (2002). Solubility prediction in supercritical CO2 using minimum number of experiments. Journal of Pharmaceutical Sciences, 91(5), 1287-1295. [More Information]
Jouyban, G., Khoubnasabjafari, M., Chan, H., Clark, B., Acree, W. (2002). Solubility prediction of Anthracene in mixed solvents using a minimum number of experimental data. Chemical and Pharmaceutical Bulletin, 50(1), 21-25. [More Information]
Chew, N., Chan, H. (2002). The role of particle properties in pharmaceutical powder inhalation formulations. Journal of Aerosol Medicine, 15(3), 325-330. [More Information]
Anderson, S., Brannan, J., Chan, H. (2002). Use of aerosols for bronchila provocation testing in the laboratory: Where we have been and where we are going. Journal of Aerosol Medicine, 15(3), 313-324. [More Information]

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2001

Chan, H., Eberl, S., Daviskas, E., Constable, C., Young,, I. (2001). Aerosol deposition and clearance measurement: a novel technique using dynamic SPET. European Journal of Nuclear Medicine and Molecular Imaging, 28, 1365-1372.
Chew, N., Chan, H., Bagster, D. (2001). Characterisation of dry powder inhalers: estimation of energy input and effect due to presence of capsule on powder dispersion. Annual Conference, : Ads & Adea.
Chew, N., Chan, H. (2001). Determinants for dispersion of powders as aerosols for inhalation. ANZSRS, : World Scientific Publishing.
Chew, N., Chan, H. (2001). Effect of the liquid properties on spray performances of thermo-liquid jet technology.
Brannan, J., Chan, H., Seale, J., Anderson, S., Gomes,, K., King,, G. (2001). Fexofenadine decreases sensitivity to and Montelukast improves recovery from inhaled Mannitol. American Journal of Respiratory and Critical Care Medicine, 163(6), 1420-1425.
Chew, N., Chan, H. (2001). In vitro aerosol performance and dose uniformity between the Foradile aerolizer and the Oxis turbuhaler. Journal of Aerosol Medicine, 14(4), 495-501.
Chan, H., Hï¿½gman,, M., Lï¿½dvfksd=ttir,, D., Anderson, S., George, S., Hskansson,, L., MerilSinen, P., Hedenstrï¿½m,, H. (2001). Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatics and healthy subjects. Respiratory Physiology and Neurobiology, 124, 141-150. [More Information]
Leuppi, J., Salome, C., Brannan, J., Chan, H., Woolcock, A., Jenkins, C., Koskela, H., Anderson, S., Andersson, M. (2001). Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. European Respiratory Journal, 18, 444-450.
Jouyban, G., Chan, H., Clark, B., Kenndler, E. (2001). Mathematical representation of electrophoretic mobility in mixed aqueous-methanolic buffers in capillary zone electrophoresis. Journal of Separation Science, 13(8), 346-350. [More Information]
Chan, H., Chew, N., Goodall, S. (2001). Particle size estimation of therapeutic aerosols produced by thermal ink jet technology.
Chew, N., Chan, H. (2001). Pharmaceutical dry powder aerosol delivery. Kona, 19, 46-55. [More Information]
Leuppi, J., Salome, C., Xuan, W., Marks, G., Brannan, J., Chan, H., Woolcock, A., Jenkins, C., Anderson, S., Koskela,, H., et al (2001). Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. American Journal of Respiratory and Critical Care Medicine, 163(2), 406-412.
Chan, H. (2001). Radiolabelling of Pharmaceutical Aerosols and Gamma Scintigraphic Imaging for Lung Deposition. (Vol. 20, pp. 255-268).
Jouyban, G., Dastmalchi, S., Chan, H., Hanaee, J., Javanmard, A., Barzegar-Jalali, M. (2001). Solubility prediction for Furosemide in water-cosolvent mixtures using the minimum number of experiments. Drug Development and Industrial Pharmacy, 27(6), 577-583.
Chan, H., Daviskas, E., Anderson, S., Eberl, S., Young,, I. (2001). The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis. Chest, 119(2), 414-421. [More Information]
Chew, N., Chan, H. (2001). Use of solid corrugated particles to enhance powder aerosol performance. Pharmaceutical Research, 18(11), 1570-1577. [More Information]

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Selected Grants

2023

Rewarding Research 2024, Chan H, Faculty of Medicine and Health/FMH Rewarding Research Success
Development of a laser-based testing platform for generic dry powder inhaler (DPI) products and in-silico model validation, Kourmatzis A, Chan H, Milton-McGurk L, The Food and Drug Administration (USA)/Research Support

2022

Treating Pulmonary Pseudomonas Infections with Bacteriophage Therapy (TERMINATE- TRIALS), Chan H, Department of Health and Aged Care (Federal)/MRFF - PPHRI - 2021 Chronic Respiratory Conditions Grant
Identification of Drug Distribution in Aerosols: A Nanospectroscopy and NanoThermal Analysis, Chan H, Khanal D, The Food and Drug Administration (USA)/Research Support
Unravelling the mechanics of particle deposition at the micro-scale, Chan H, Kourmatzis A, Australian Research Council (ARC)/Discovery Projects (DP)
Development of inhaled therapeutics using endolysin, Chang R, Chan H, Ministry of Trade, Industry and Energy (KOREA)/Industrial Technology Innovation Program
Inhaled phage-antibiotic therapy for combating respiratoryinfections caused by superbugs, Chan H, Cho Y, Chang R, Department of Foreign Affairs and Trade (Federal)/Australia-Korea Foundation

2021

Understanding bacteriophage deactivation and stabilisation in formulations, Chan H, Banaszak Holl M, Morales S, Australian Research Council (ARC)/Discovery Projects (DP)

2020

A novel approach for the real-time measurement of aerosol surface area, Chan H, Kourmatzis A, Cheng S, Australian Research Council (ARC)/Linkage Projects (LP)
High-load powder dispersion and aerosol delivery: an integrated approach, Chan H, Yang R, Kourmatzis A, Australian Research Council (ARC)/Linkage Projects (LP)

2018

Argon gas sorption analyser for nanomaterials, catalysts, and pharmaceuticals, Chan H, Maschmeyer T, Chen Y, DVC Research/Equipment Grant
Particle transport in the human upper airway, Chan H, Kourmatzis A, Australian Research Council (ARC)/Discovery Projects (DP)
Development of computational models to predict delivery of inhalation drug powders: from deagglomeration in devices to deposition in airways, Chan H, Yang R, Kourmatzis A, Cheng S, The Food and Drug Administration (USA)/Research Support
Novel nano-composite particles for controlled-release drugs via inhalation, Chan H, Cipolla D, Chrzanowski W, Australian Research Council (ARC)/Linkage Projects (LP)

2017

Infection-on-a-chip.Multi-organ microfluidic platform for drug discovery, precision biology and microbiology., Chan H, Ashish Kumar T, New E, National Health and Medical Research Council (NHMRC)/Equipment Grant
Novel inhalation formulation of bacteriophages against superbugs causing respiratory infections, Morgan K, Chan H, McLachlan A, Morales S, National Health and Medical Research Council (NHMRC)/Project Grants

2016

In Vivo Pulmonary Deposition of Aerosols Generated by Surface Acoustic Waves Novel Nebuliser, Yeo L, Chan H, Department of Industry, Science and Resources/Accelerating Commercialisation Grant
The role of electrostatic charge in airway deposition of aerosols, Chan H, Finlay W, Australian Research Council (ARC)/Discovery Projects (DP)

2015

Advanced NanoSight NS300 System , Halliday G, Richardson D, Chan H, Grau G, Shackel N, University of Sydney/Equipment Grant
Optimising inhaled polymyxins as a vital therapy for pulmonary infections: A novel biochemical, molecular imaging and systems pharmacology approach, Li J, Zhou Q, Zhou F, Chan H, Velkov T, National Health and Medical Research Council (NHMRC)/Project Grants
Harnessing bacteriophages as natural predators to combat the superbugs: a pulmonary drug delivery approach, Chan H, Li J, National Institutes of Health (USA)/Research Support
Endeavour Fellowship, Chan H, Department of Industry, Science and Resources/Endeavour Fellowship
Enabling aerosol delivery of phages to defeat antibiotic-resistant bacteria, Chan H, Finlay W, Carter E, Vehring R, Australian Research Council (ARC)/Discovery Projects (DP)
Inhalational delivery system for delivery of drugs to treat lung infections with Mycobacterium tuberculosis and Pseudomonas aeruginosa, Britton W, Chan H, Triccas J, Saunders B, Rebecca L Cooper Medical Research Foundation/Research Support

2014

Live Cell Accessories for Raman and FTIR Imaging , Lay P, Hawkins C, Grau G, Witting P, Chan H, DVC Research/Equipment Grant
Inhalation Delivery Sysytem for Drug and Vaccine Delivery , Britton W, Chan H, Triccas J, Rutledge P, Traini D, DVC Research/Equipment Grant

2013

University of Sydney Automated Peptide Synthesis Platform, Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N, National Health and Medical Research Council (NHMRC)/Equipment Grant
Novel inhalation formulation of colistin and combination therapy against Gram-negative superbugs, Chan H, Zhou Q, Li J, Fouras A, National Health and Medical Research Council (NHMRC)/Project Grants
Phase 1 clinical trial: Inhaled rifapentine for rapid treatment of tuberculosis, Chan H, McLachlan A, Chan J, Parumasivam T, Rebecca L Cooper Medical Research Foundation/Equipment Grant
Developing a Biotherapeutic Protein Delivery System for Pulmonary Tract, Kayser V, Chan H, University of Sydney, Faculty of Pharmacy/Equipment Grant
Eradicating pulmonary tuberculosis using multi-functional inhalable particles, Prud'homme R, Chan H, DVC Research/International Research Collaboration Award (IRCA)

2012

WITEC Alpha 300R High Throughput Microscope - Confocal Raman Microscope, Traini D, Young P, Murray M, Dehghani F, Chan H, Oliver B, Holst J, DVC Research/Equipment Grant
Improving subunit vaccines against tuberculosis for pulmonary delivery, Britton W, West N, Payne R, Chan H, National Health and Medical Research Council (NHMRC)/Project Grants
nanoIR - nanoscale bioimaging with continuous mapping of chemical and physical properties, Chang L, Chrzanowski W, Dehghani F, Gan Y, Gomes V, Hanaor D, Jabbarzadeh A, McKenzie D, Zhou F, Braet F, Bilek M, Chan H, Perrier S, O'Neill G, Ammit A, Brand-Miller J, McEwan A, Hawkett B, Kondyurin A, Li Q, Burgess J, Li Z, National Health and Medical Research Council (NHMRC)/Equipment Grant
Production of nano-composite particles for inhalational delivery of combination drugs, Chan H, Australian Research Council (ARC)/Discovery Projects (DP)

2011

The effect of electrostatic charge on the plume of pressurised metered dose inhalers, Lewis D, Traini D, Young P, Chan H, Australian Research Council (ARC)/Linkage Projects (LP)
Engineering of composite particles to enhance performance in respiratory drug delivery, Saunders M, Traini D, Young P, Chan H, Australian Research Council (ARC)/Linkage Projects (LP)

2010

Developing novel aerosol inhalers for pulmonary drug delivery from the fundamental understanding of powder dispersion mechanisms, Chan H, Yang R, Australian Research Council (ARC)/Discovery Projects (DP)
qNano scanning ion occlusion spectroscopy (SIOS), Chrzanowski W, Bebawy M, Dehghani F, Chan H, Rohanizadeh R, Hawkett B, National Health and Medical Research Council (NHMRC)/Equipment Grant
Aerosol delivery systems of siRNA for the treatment of lung cancer, Chan H, Department of Trade and Investment, Regional Infrastructure and Services (NSW)/Research Support

2009

Powder Aerolsols for Inahalation, Chan H, DVC Research/Bridging Support Grant
Advanced Focused Ion Beam (FIB) / Scanning Electron Microscopes (SEM) for Nanometre Scale Characterisation and Fabrication, Cairney J, Munroe P, Ringer S, Ferry M, Mai Y, Liao X, McKenzie D, Wenham S, Dzurak A, Stevens-Kalceff M, Spinks G, Dou S, Valanoor N, Liu Z, Proust G, Young D, Braet F, Chan-Ling T, Maschmeyer T, Chan H, Traini D, Swain M, Harris A, Crawford J, Potts D, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
Surface Energy Analyser (SEA), Traini D, Young P, Chan H, Rohanizadeh R, Bilek M, Langrish T, Gomes V, National Health and Medical Research Council (NHMRC)/Equipment Grant

2008

Development of a novel process for the formation of particles with controlled surface architecture for respiratory drug delivery, Chan H, Australian Research Council (ARC)/Discovery Projects (DP)
PSIA Thermal Atomic Force Microscope (AFM), XE-70 SPM system plus Scanning Thermal Microscope, Chan H, Murray M, Traini D, Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment

2007

The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery, Chan H, Foster N, Foster N, Australian Research Council (ARC)/Linkage Projects (LP)
Nanoscale Thermal Imaging (SThM), Braet F, Chan H, Traini D, Yang W, Young P, National Health and Medical Research Council (NHMRC)/Equipment Grant

2006

Engineering a delivery device and development of a novel formulation for chronic obstructive pulmonary disease and cystic fibrosis, Crapper J, Fletcher D, Young P, Chan H, Traini D, Australian Research Council (ARC)/Linkage Projects (LP)
State of the art high resolution thermal analysis suite for the life and material sciences, Chan H, Dehghani F, Hibbs D, Larson I, Murray M, Stewart P, Traini D, Warr G, Weiss A, Young P, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
Precision Titration/ Solution Calorimeter accessory for the Tam III Iosthermal calorimeter Calorimet, Chan H, Hibbs D, Murray M, Stewart P, Traini D, Weiss A, Young P, National Health and Medical Research Council (NHMRC)/Equipment Grant
Mannitol Powders for Assessment of Asthma in Children, Chan H, Crapper J, Traini D, Young P, Australian Research Council (ARC)/Linkage Projects (LP)
Discrete simulation of powder dispersion in pharmaceutical aerosol inhalers, Chan H, Yang R, Yang R, Australian Research Council (ARC)/Discovery Projects (DP)
Linkage Round 2 2004 - High gravity precipitation of nanoparticles for pulmonary drug delivery, Chan H, Golding J, NanoMaterials Technology Pty Ltd (Singapore)/Project Support

2005

Molecular Simulation of the Effects of Additives on Generation of Dry Powder Aerosols, Chan H, Hibbs D, University of Sydney/Research & Development
Formulation Of Anti-Inflammatory Aerosols For The Treatment Of Pathogenic Lung Infection, Chan H, Traini D, Young P, Pharmacy Research Trust of NSW/Research Grants Program
Characterising particulate laden flow in the lung airways: from drug delivery to primary anthropogen, Chan H, Honnery D, Larson I, Soria J, Stewart P, Thompson B, Young P, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
University of Sydney - Bridging Support Grant, Chan H, University of Sydney/Bridging Support

2004

High gravity precipitation of nanoparticles for pulmonary drug delivery, Chan H, Raper J, Australian Research Council (ARC)/Linkage Projects (LP)
Bronchoprovocation Testing In Children Using Mannitol Powder Aerosols, Anderson S, Chan H, Devadason S, Sly P, National Health and Medical Research Council (NHMRC)/Development Grants
Particulate Characterisation for Pharmaceutical and Engineering Applications, Amal R, Chan H, Coombes A, Langrish T, Romagnoli J, Stewart P, Valix M, Yang R, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)

2003

Synthesis and PET-radiolabelling of inhalation aerosols for lung deposition and disposition studies, Chan H, DVC Research/Research and Development Scheme: Research and Development (R&D)
Synthesis of nanoparticles by impinging liquid-jet precipitation for inhalation drug delivery, Chan H, Prud'homme R, Raper J, Australian Research Council (ARC)/Discovery Projects (DP)

2002

Pharmaceutical Application of a High Gravity Precipitation Process, Chan H, Yun J, Nano Materials Technology Pty Ltd Singapore/BLO Project

2001

Dispersion of pharmaceutical powders as aerosols for inhalation, Chan H, Mazumder M, Raper J, Rutland M, Australian Research Council (ARC)/Discovery Projects (DP)
Pharmaceutical Powder Aerosol Delivery: A Lung Deposition Study, Chan H, DVC Research/Research and Development Scheme: Research and Development (R&D)

2000

An open-label, randomised,three way crossover study to evaluate oropharyngeal & intrapulmonary deposition of 99mTc-DTPA in healthey volunteers following inhalation using different configuration of the second generation AERx system(SLICE), Chan H, Aradigm Corporation/Research Grants
SLICE 01-02 An open-label, two-way crossover study to evaluate oropharyngeal and intrapulmonary deposition of 99mTc-DTPA in healthy volunteers following inhalation using two different versions of a hand-held, all mechanical AERx system (SLICE)., Chan H, Aradigm Corporation/Research Grants
Not known, Chan H, Okikawa J, Aradigm Corporation/Research Grants
A Novel Aerosol Inhaler by Thermal Liquid Jet Technology, Chan H, Goodall S, Lennon A, Robertson P, Australian Research Council (ARC)/Strategic Partnerships with Industry - Research and Training (SPIRT)

1999

Micronisation of poorly water soluble pharmaceuticals, Chan H, Foster M, Australian Research Council (ARC)/Large Research Grants (LRG)
Fluicaps - proof of concept of research, Chan H, Tait R, Soltec Research Ltd/Research Support
Development of a methodology to quantify lung deposition of radio-labelled MDIs, Chan H, 3M Pharmaceuticals Pty Ltd/Research Support
An ultrasonic PCA (precipitation with compressed anti-solven) process fo protein powder production, Chan H, Australian Research Council (ARC)/Large Research Grants (LRG)

Faculty of Medicine and Health

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Professor Kim Chan

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