People_

Dr Kwok Leung Ong

Senior Research Fellow
NHMRC Clinical Trials Centre
Faculty of Medicine and Health

Email

kwok.ong@sydney.edu.au

Dr Kwok Leung Ong (PhD, 2010) is a Senior Research Fellow and his research interests include (i) identification of plasma biomarkers for cardiovascular disease and its risk factors; and (ii) epidemiology of CVD risk factors with publication of one book chapter, 94 original articles, 16 reviews, and 3 letters to the editor in peer-reviewed journals that have attracted 6991 citations (h-index = 40; Google Scholar 14/8/2023). Dr Ong’s contribution to CVD research has been recognized by his appointment as a Fellow of the American Heart Association (AHA) in 2016, and an editorial board member of the Journal of AHA since 2021. He has actively contributed as a grant review panel member to the NHMRC and the National Heart Foundation.

Research interests

Identification of biomarkers for cardiovascular risk factors, such as dyslipidaemia, diabetes, hypertension and the metabolic syndrome
Epidemiology of different cardiovascular risks factors, such as prevalence, control and treatment using date from longitudinal cohorts, clinical trials and administrative health data
Anti-inflammatory effects of high-density lipoproteins and lipid-lowering medications

Publications

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Journals

Manandhar, B., Pandzic, E., Deshpande, N., Chen, S., Wasinger, V., Kockx, M., Glaros, E., Ong, K., Thomas, S., Wilkins, M., et al (2024). ApoA-I Protects Pancreatic β-Cells From Cholesterol-Induced Mitochondrial Damage and Restores Their Ability to Secrete Insulin. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(2), e20-e38. [More Information]
Tucker, W., Tucker, B., Januszewski, A., Jenkins, A., Keech, A., Kestenbaum, B., Allison, M., Rye, K., Ong, K. (2024). Association of circulating fibroblast growth factor 21 levels with all-cause and cardiovascular mortality: The multi-ethnic study of atherosclerosis. Clinica Chimica Acta, 555, 117799. [More Information]
Januszewski, A., Young, H., Ong, K., Li, L., O'Connell, R., Lyons, T., Kelly, C., Zaharieva, D., Sullivan, D., Scott, R., Keech, A., Jenkins, A. (2024). Haptoglobin phenotype and levels in type 2 diabetes and effects of fenofibrate. Journal of Diabetes Investigation, 15(11), 1663-1668. [More Information]
Ong, K., Marklund, M., Huang, L., Rye, K., Hui, N., Pan, X., Rebholz, C., Kim, H., Steffen, L., Van Westing, A., et al (2023). Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. BMJ. [More Information]
Tucker, W., Tucker, B., Rye, K., Ong, K. (2023). Fibroblast growth factor 21 in heart failure. Heart Failure Reviews, 28(1), 261-272. [More Information]
Qian, F., Tintle, N., Jensen, P., Lemaitre, R., Imamura, F., Feldreich, T., Nomura, S., Guan, W., Laguzzi, F., Kim, E., Ong, K., et al (2023). Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation. Journal of the American College of Cardiology, 82(4), 336-349. [More Information]
Hammaréus, F., Nilsson, L., Ong, K., Kristenson, M., Festin, K., Lundberg, A., Chung, R., Swahn, E., Alfredsson, J., Holm Nielsen, S., et al (2023). Plasma type i collagen α1 chain in relation to coronary artery disease: Findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden. BMJ Open, 13(9). [More Information]
Sayanthan, S., Allison, M., Budoff, M., Rye, K., Ong, K. (2023). Relationship of fibroblast growth factor 21 with the prevalence and progression of vascular and valvular calcification: Multi-ethnic study of atherosclerosis. International Journal of Cardiology, 370, 388-395. [More Information]
Tucker, W., McClelland, R., Allison, M., Szklo, M., Rye, K., Ong, K. (2023). The association of circulating fibroblast growth factor 21 levels with incident heart failure: The Multi-Ethnic Study of Atherosclerosis. Metabolism: Clinical and Experimental, 143(155535). [More Information]
Wang, H., Tucker, W., Jonnagaddala, J., Schutte, A., Jalaludin, B., Liaw, S., Rye, K., Wong, R., Ong, K. (2023). Using machine learning to predict cardiovascular risk using self-reported questionnaires: Findings from the 45 and Up Study. International Journal of Cardiology, 386, 149-156. [More Information]
Ong, K., Cochran BBiotech, B., Manandhar, B., Thomas, S., Rye, K. (2022). HDL maturation and remodelling. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1867 (4). [More Information]
Zhou, Z., Ong, K., Whelton, S., Allison, M., Curtis, A., Blaha, M., Breslin, M., Tonkin, A., Magnussen, C., Budoff, M., et al (2022). Impact of Blood Lipids on 10-Year Cardiovascular Risk in Individuals Without Dyslipidemia and With Low Risk Factor Burden. Mayo Clinic Proceedings, 97(10), 1883-1893. [More Information]
Kadappu, P., Jonnagaddala, J., Liaw, S., Cochran, B., Rye, K., Ong, K. (2022). Statin Prescription Patterns and Associations with Subclinical Inflammation. Medicina, 58(8). [More Information]
Cochran, B., Ong, K., Manandhar, B., Rye, K. (2021). APOA1: a Protein with Multiple Therapeutic Functions. Current Atherosclerosis Reports, 23(3). [More Information]
Ho, J., Ong, K., Cuesta Torres, L., Liu, Y., Adam, S., Iqbal, Z., Dhage, S., Ammori, B., Syed, A., Rye, K., et al (2021). High density lipoprotein-associated miRNA is increased following Roux-en-Y gastric bypass surgery for severe obesity. Journal of Lipid Research, 62. [More Information]
Cochran, B., Ong, K., Manandhar, B., Rye, K. (2021). High density lipoproteins and diabetes. Cells, 10(4). [More Information]
Ho, J., Ong, K., Cuesta Torres, L., Liu, Y., Adam, S., Iqbal, Z., Dhage, S., Ammori, B., Syed, A., Rye, K., et al (2021). High-density lipoprotein-associated miRNA is increased following Roux-en-Y gastric bypass surgery for severe obesity. Journal of Lipid Research, 62, 100043. [More Information]
Ong, K., McClelland, R., Allison, M., Cushman, M., Garg, P., Tsai, M., Rye, K., Tabet, F. (2021). Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors. Metabolism: Clinical and Experimental, 116. [More Information]
Hui, N., Morris, M., Allison, M., Tsai, M., Rye, K., Tabet, F., Ong, K. (2021). Lipoprotein (a) and the risk of elevated depressive symptoms: The Multi-Ethnic Study of Atherosclerosis. Journal of Psychiatric Research, 133, 119-124. [More Information]
Sawant, S., Tucker, B., Senanayake, P., Waters, D., Patel, S., Rye, K., Ong, K., Cochran, B. (2021). The association between lipid levels and leukocyte count: A cross-sectional and longitudinal analysis of three large cohorts. American Heart Journal Plus: cardiology research and practice, 4. [More Information]
Tucker, B., Sawant, S., McDonald, H., Rye, K., Patel, S., Ong, K., Cochran, B. (2021). The association of serum lipid and lipoprotein levels with total and differential leukocyte counts: Results of a cross-sectional and longitudinal analysis of the UK Biobank. Atherosclerosis, 319, 1-9. [More Information]
Ong, K., Wu, L., Januszewski, A., O'Connell, R., Xu, A., Scott, R., Sullivan, D., Rye, K., Li, H., Ma, R., Li, L., Gebski, V., Jenkins, A., Keech, A., et al (2021). The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study. Diabetes and Vascular Disease Research, 18(4). [More Information]
Zhou, Z., Ong, K., Breslin, M., Allison, M., Curtis, A., Nelson, M. (2020). Association of Statin Use With Cardiovascular Outcomes by Coronary Calcium: MESA. JACC: Cardiovascular Imaging, 13(4), 1094-1096. [More Information]
Tucker, B., McClelland, R., Allison, M., Budoff, M., Wu, B., Barter, P., Rye, K., Ong, K. (2020). Relationship of fibroblast growth factor 21 levels with inflammation, lipoproteins and non-alcoholic fatty liver disease. Atherosclerosis, 299, 38-44. [More Information]
Ong, K., Wu, L., Januszewski, A., O'Connell, R., Xu, A., Rye, K., Ma, R., Li, H., Jenkins, A., Jia, W., Keech, A. (2020). Relationships of adipocyte-fatty acid binding protein and lipocalin 2 with risk factors and chronic complications in type 2 diabetes and effects of fenofibrate: A fenofibrate Intervention and event lowering in diabetes sub-study. Diabetes Research and Clinical Practice, 169, 108450. [More Information]
Ong, K., Chung, R., Hui, N., Festin, K., Lundberg, A., Rye, K., Jonasson, L., Kristenson, M. (2020). Usefulness of Certain Protein Biomarkers for Prediction of Coronary Heart Disease. American Journal of Cardiology, 125(4), 542-548. [More Information]
Hui, N., Barter, P., Ong, K., Rye, K. (2019). Altered HDL metabolism in metabolic disorders: Insights into the therapeutic potential of HDL. Clinical Science, 133(21), 2221-2235. [More Information]
Wu, B., Sun, Y., Ong, K., Li, Y., Tang, S., Barter, P., Rye, K. (2019). Apolipoprotein A-I Protects Against Pregnancy-Induced Insulin Resistance in Rats. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(6), 1160-1171. [More Information]
Hou, L., Tang, S., Wu, B., Ong, K., Westerterp, M., Barter, P., Cochran, B., Tabet, F., Rye, K. (2019). Apolipoprotein A-l improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1. The FASEB Journal, 33(7), 8479-8489. [More Information]
Ong, K., McClelland, R., Allison, M., Kokkinos, J., Wu, B., Rye, K., Barter, P. (2019). Association of elevated circulating fibroblast growth factor 21 levels with prevalent and incident metabolic syndrome: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 281, 200-206. [More Information]
Anuwatmatee, S., Tang, S., Wu, B., Rye, K., Ong, K. (2019). Fibroblast growth factor 21 in chronic kidney disease. Clinica Chimica Acta, 489, 196-202. [More Information]
Tucker, B., Li, H., Long, X., Rye, K., Ong, K. (2019). Fibroblast growth factor 21 in non-alcoholic fatty liver disease. Metabolism: Clinical and Experimental, 101. [More Information]
Ong, K., Hui, N., Januszewski, A., Kaakoush, N., Xu, A., Fayyad, R., DeMicco, D., Jenkins, A., Keech, A., Waters, D., et al (2019). High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the treating to new targets [TNT] study). Metabolism: Clinical and Experimental, 93, 93-99. [More Information]
Anuwatmatee, S., Allison, M., Shlipak, M., McClelland, R., Kramer, H., Tang, S., Hou, L., Rye, K., Ong, K. (2019). Relationship of fibroblast growth factor 21 with kidney function and albuminuria: Multi-ethnic study of atherosclerosis. Nephrology Dialysis Transplantation, 34(6), 1009-1016. [More Information]
Ong, K., Campbell, S., Wu, B., McClelland, R., Kokkinos, J., Szklo, M., Polak, J., Allison, M., Rye, K. (2019). Relationship of fibroblast growth factor 21 with subclinical atherosclerosis and cardiovascular events: Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 287, 46-53. [More Information]
Yuan, D., Wu, B., Henry, A., Rye, K., Ong, K. (2019). Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini-review. Clinical Endocrinology, 90(1), 47-55. [More Information]
Lai, Y., Woollard, K., McClelland, R., Allison, M., Rye, K., Ong, K., Cochran, B. (2019). The association of plasma lipids with white blood cell counts: Results from the Multi-Ethnic Study of Atherosclerosis. Journal of Clinical Lipidology, 13(5), 812-820. [More Information]
Wu, B., Li, Y., Ong, K., Sun, Y., Johns, D., Barter, P., Rye, K. (2019). The Cholesteryl Ester Transfer Protein Inhibitor, des-Fluoro-Anacetrapib, Prevents Vein Bypass-induced Neointimal Hyperplasia in New Zealand White Rabbits. Scientific Reports, 9(1). [More Information]
Magdas, A., Ding, J., McClelland, R., Allison, M., Barter, P., Rye, K., Ong, K. (2019). The relationship of circulating fibroblast growth factor 21 levels with pericardial fat: The Multi-Ethnic Study of Atherosclerosis. Scientific Reports, 9(1). [More Information]
Lakhani, I., Gong, M., Wong, W., Bazoukis, G., Lampropoulos, K., Wong, S., Wu, W., Wong, M., Ong, K., Liu, T., et al (2018). Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis. Metabolism: Clinical and Experimental, 83, 11-17. [More Information]
Ong, K., Waters, D., Fayyad, R., Vogt, L., Melamed, S., DeMicco, D., Rye, K., Barter, P. (2018). Relationship of High-Density Lipoprotein Cholesterol With Renal Function in Patients Treated With Atorvastatin. Journal of the American Heart Association, 7(2), 1-7. [More Information]
Ong, K., Morris, M., McClelland, R., Hughes, T., Maniam, J., Fitzpatrick, A., Martin, S., Luchsinger, J., Rapp, S., Hayden, K., et al (2018). Relationship of Lipids and Lipid-Lowering Medications with Cognitive Function. American Journal of Epidemiology, 187(4), 767-776. [More Information]
Hui, T., McClelland, R., Allison, M., Rodriguez, C., Kronmal, R., Heckbert, S., Michos, E., Barter, P., Rye, K., Ong, K. (2018). The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 269, 86-91. [More Information]
Choteau, S., Cuesta Torres, L., Barraclough, J., Elder, A., Martinez, G., Chen Fan, W., Shrestha, S., Ong, K., Barter, P., Celermajer, D., et al (2018). Transcoronary gradients of HDL-associated MicroRNAs in unstable coronary artery disease. International Journal of Cardiology, 253, 138-144. [More Information]
Ong, K., O'Connell, R., Januszewski, A., Jenkins, A., Xu, A., Sullivan, D., Barter, P., Scott, R., Taskinen, M., Waldman, B., Simes, R., Rye, K., Keech, A., et al (2017). Baseline circulating FGF21 concentrations and increase after fenofibrate treatment predict more rapid glycemic progression in type 2 diabetes: Results from the FIELD study. Clinical Chemistry, 63(7), 1261-1270. [More Information]
Wu, B., Li, Y., Ong, K., Sun, Y., Shrestha, S., Hou, L., Johns, D., Barter, P., Rye, K. (2017). Reduction of in-stent restenosis by cholesteryl ester transfer protein inhibition. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(12), 2333-2341. [More Information]
Kokkinos, J., Tang, S., Rye, K., Ong, K. (2017). The role of fibroblast growth factor 21 in atherosclerosis. Atherosclerosis, 257, 259-265. [More Information]
Tabet, F., Torres, L., Ong, K., Shrestha, S., Choteau, S., Barter, P., Clifton, P., Rye, K. (2016). High-density lipoprotein-associated miR-223 is altered after diet-induced weight loss in overweight and obese males. PloS One, 11(3). [More Information]
Ong, K., Morris, M., McClelland, R., Maniam, J., Allison, M., Rye, K. (2016). Lipids, lipoprotein distribution and depressive symptoms: The multi-ethnic study of atherosclerosis. Translational Psychiatry, 6(11). [More Information]
Wu, B., Shrestha, S., Ong, K., Johns, D., Hou, L., Barter, P., Rye, K. (2015). Cholesteryl ester transfer protein inhibition enhances endothelial repair and improves endothelial function in the rabbit. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(3), 628-636. [More Information]
Wu, H., Ong, K., Seeher, K., Armstrong, N., Thalamuthu, A., Brodaty, H., Sachdev, P., Mather, K. (2015). Circulating microRNAs as biomarkers of alzheimer's disease: A systematic review. Journal of Alzheimer's Disease, 49(3), 755-766. [More Information]
Wu, B., Shrestha, S., Ong, K., Johns, D., Dunn, L., Hou, L., Barter, P., Rye, K. (2015). Increasing HDL levels by inhibiting cholesteryl ester transfer protein activity in rabbits with hindlimb ischemia is associated with increased angiogenesis. International Journal of Cardiology, 199, 204-212. [More Information]
Ong, K., Januszewski, A., O'Connell, R., Buizen, L., Jenkins, A., Xu, A., Sullivan, D., Barter, P., Scott, R., Taskinen, M., Rye, K., Keech, A. (2015). Relationship of fibroblast growth factor 21 with baseline and new on-study microvascular disease in the Fenofibrate Intervention and Event Lowering in Diabetes study. Diabetologia, 59(8), 2035-2044. [More Information]
Ong, K., Ding, J., McClelland, R., Cheung, B., Criqui, M., Barter, P., Rye, K., Allison, M. (2015). Relationship of pericardial fat with biomarkers of inflammation and hemostasis, and cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 239(2), 386-392. [More Information]
Ong, K., Ding, J., McClelland, R., Cheung, B., Criqui, M., Barter, P., Rye, K., Allison, M. (2015). Relationship of pericardial fat with lipoprotein distribution: The Multi-Ethnic study of atherosclerosis. Atherosclerosis, 241(2), 664-670. [More Information]
Besseling, J., Ong, K., Huijgen, R., Rye, K., Hovingh, G., Hutten, B., Lambert, G. (2015). The impact of LDLR function on fibroblast growth factor 21 levels. Atherosclerosis, 241(2), 322-325. [More Information]
Ong, K., Januszewski, A., O'Connell, R., Jenkins, A., Xu, A., Sullivan, D., Barter, P., Hung, W., Scott, R., Taskinen, M., Keech, A., Rye, K. (2015). The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes study. Diabetologia, 58(3), 464-473. [More Information]
Cheung, C., Hui, E., Cheung, B., Woo, Y., Xu, A., Fong, C., Ong, K., Yeung, C., Janus, E., Tse, H., et al (2014). Adiponectin gene variants and the risk of coronary heart disease: A 16-year longitudinal study. European Journal of Endocrinology, 171(1), 107-115. [More Information]
Ong, K., Barter, P., Waters, D. (2014). Cardiovascular drugs that increase the risk of new-onset diabetes. American Heart Journal, 167(4), 421-428. [More Information]
Ong, K., Waters, D., Messig, M., DeMicco, D., Rye, K., Barter, P. (2014). Effect of Change in Body Weight on Incident Diabetes Mellitus in Patients With Stable Coronary Artery Disease Treated With Atorvastatin (from the Treating to New Targets Study). American Journal of Cardiology, 113(10), 1593-1598. [More Information]
Wu, B., Ong, K., Shrestha, S., Chen, K., Tabet, F., Barter, P., Rye, K. (2014). Inhibition of Arthritis in the Lewis Rat by Apolipoprotein A-I and Reconstituted High-Density Lipoproteins. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(3), 543-551. [More Information]
Ong, K., McClelland, R., Rye, K., Cheung, B., Post, W., Vaidya, D., Criqui, M., Cushman, M., Barter, P., Allison, M. (2014). The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 236(2), 257-262. [More Information]
Ong, K., Allison, M., Cheung, B., Wu, B., Barter, P., Rye, K. (2014). The Relationship between Total Bilirubin Levels and Total Mortality in Older Adults: The United States National Health and Nutrition Examination Survey (NHANES) 1999-2004. PloS One, 9(14), 1-8. [More Information]
Wong, H., Ong, K., cheung, C., Cheung, B. (2014). Utilization of glucose, blood pressure, and lipid lowering medications among people with type II diabetes in the United States, 1999-2010. Annals of Epidemiology, 24(7), 516-521. [More Information]
Wong, H., Ong, K., Leung, R., Lam, T., Thomas, G., Lam, K., Cheung, B. (2013). A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels. Clinical Endocrinology, 79(4), 504-509. [More Information]
Ong, K., Wu, B., Cheung, B., Barter, P., Rye, K. (2013). Arthritis: Its prevalence, risk factors, and association with cardiovascular diseases in the United States, 1999 to 2008. Annals of Epidemiology, 23(2), 80-86. [More Information]
Wu, B., Chen, K., Shrestha, S., Ong, K., Barter, P., Rye, K. (2013). High Density Lipoproteins Inhibit Vascular Endothelial Inflammation by Increasing 3[beta]-Hydroxysteroid-{Delta}24 Reductase Expression and Inducing Heme Oxygenase-1. Circulation Research, 112(2), 278-288. [More Information]
Wong, H., Ong, K., Leung, R., Cheung, T., Xu, A., Lam, T., Lam, K., Cheung, B. (2013). Plasma Level of Adrenomedullin Is Influenced by a Single Nucleotide Polymorphism in the Adiponectin Gene. PloS One, 8(8). [More Information]
Ong, K., Allison, M., Cheung, B., Wu, B., Barter, P., Rye, K. (2013). Trends in C-Reactive Protein Levels in US Adults From 1999 to 2010. American Journal of Epidemiology, 177(12), 1430-1442. [More Information]
Ong, K., Rye, K., O'Connell, R., Jenkins, A., Brown, C., Xu, A., Sullivan, D., Barter, P., Keech, A. (2012). Long-Term Fenofibrate Therapy Increases Fibroblast Growth Factor 21 and Retinol-Binding Protein 4 in Subjects with Type 2 Diabetes. Journal of Clinical Endocrinology and Metabolism, 97(12), 4701-4708. [More Information]
Ong, K., Wu, B., Cheung, B., Barter, P., Rye, K. (2011). Association of lower total bilirubin level with statin usage: The United States National Health and Nutrition Examination Survey 1999-2008. Atherosclerosis, 219(2), 728-733. [More Information]
Ong, K., Tso, A., Xu, A., Law, L., Li, M., Wat, N., Rye, K., Lam, T., Cheung, B., Lam, K. (2011). Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years. Diabetologia, 54(10), 2552-2560. [More Information]

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Conferences

Wang, H., Wong, R., Ong, K. (2024). A Data-Driven Approach for Building a Cardiovascular Disease Risk Prediction System. Advances in Knowledge Discovery and Data Mining, Taiwan: Springer. [More Information]

By Year

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2024

Wang, H., Wong, R., Ong, K. (2024). A Data-Driven Approach for Building a Cardiovascular Disease Risk Prediction System. Advances in Knowledge Discovery and Data Mining, Taiwan: Springer. [More Information]
Manandhar, B., Pandzic, E., Deshpande, N., Chen, S., Wasinger, V., Kockx, M., Glaros, E., Ong, K., Thomas, S., Wilkins, M., et al (2024). ApoA-I Protects Pancreatic β-Cells From Cholesterol-Induced Mitochondrial Damage and Restores Their Ability to Secrete Insulin. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(2), e20-e38. [More Information]
Tucker, W., Tucker, B., Januszewski, A., Jenkins, A., Keech, A., Kestenbaum, B., Allison, M., Rye, K., Ong, K. (2024). Association of circulating fibroblast growth factor 21 levels with all-cause and cardiovascular mortality: The multi-ethnic study of atherosclerosis. Clinica Chimica Acta, 555, 117799. [More Information]
Januszewski, A., Young, H., Ong, K., Li, L., O'Connell, R., Lyons, T., Kelly, C., Zaharieva, D., Sullivan, D., Scott, R., Keech, A., Jenkins, A. (2024). Haptoglobin phenotype and levels in type 2 diabetes and effects of fenofibrate. Journal of Diabetes Investigation, 15(11), 1663-1668. [More Information]

show 1 more

2023

Ong, K., Marklund, M., Huang, L., Rye, K., Hui, N., Pan, X., Rebholz, C., Kim, H., Steffen, L., Van Westing, A., et al (2023). Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts. BMJ. [More Information]
Tucker, W., Tucker, B., Rye, K., Ong, K. (2023). Fibroblast growth factor 21 in heart failure. Heart Failure Reviews, 28(1), 261-272. [More Information]
Qian, F., Tintle, N., Jensen, P., Lemaitre, R., Imamura, F., Feldreich, T., Nomura, S., Guan, W., Laguzzi, F., Kim, E., Ong, K., et al (2023). Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation. Journal of the American College of Cardiology, 82(4), 336-349. [More Information]
Hammaréus, F., Nilsson, L., Ong, K., Kristenson, M., Festin, K., Lundberg, A., Chung, R., Swahn, E., Alfredsson, J., Holm Nielsen, S., et al (2023). Plasma type i collagen α1 chain in relation to coronary artery disease: Findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden. BMJ Open, 13(9). [More Information]
Sayanthan, S., Allison, M., Budoff, M., Rye, K., Ong, K. (2023). Relationship of fibroblast growth factor 21 with the prevalence and progression of vascular and valvular calcification: Multi-ethnic study of atherosclerosis. International Journal of Cardiology, 370, 388-395. [More Information]
Tucker, W., McClelland, R., Allison, M., Szklo, M., Rye, K., Ong, K. (2023). The association of circulating fibroblast growth factor 21 levels with incident heart failure: The Multi-Ethnic Study of Atherosclerosis. Metabolism: Clinical and Experimental, 143(155535). [More Information]
Wang, H., Tucker, W., Jonnagaddala, J., Schutte, A., Jalaludin, B., Liaw, S., Rye, K., Wong, R., Ong, K. (2023). Using machine learning to predict cardiovascular risk using self-reported questionnaires: Findings from the 45 and Up Study. International Journal of Cardiology, 386, 149-156. [More Information]

show 4 more

2022

Ong, K., Cochran BBiotech, B., Manandhar, B., Thomas, S., Rye, K. (2022). HDL maturation and remodelling. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1867 (4). [More Information]
Zhou, Z., Ong, K., Whelton, S., Allison, M., Curtis, A., Blaha, M., Breslin, M., Tonkin, A., Magnussen, C., Budoff, M., et al (2022). Impact of Blood Lipids on 10-Year Cardiovascular Risk in Individuals Without Dyslipidemia and With Low Risk Factor Burden. Mayo Clinic Proceedings, 97(10), 1883-1893. [More Information]
Kadappu, P., Jonnagaddala, J., Liaw, S., Cochran, B., Rye, K., Ong, K. (2022). Statin Prescription Patterns and Associations with Subclinical Inflammation. Medicina, 58(8). [More Information]

2021

Cochran, B., Ong, K., Manandhar, B., Rye, K. (2021). APOA1: a Protein with Multiple Therapeutic Functions. Current Atherosclerosis Reports, 23(3). [More Information]
Ho, J., Ong, K., Cuesta Torres, L., Liu, Y., Adam, S., Iqbal, Z., Dhage, S., Ammori, B., Syed, A., Rye, K., et al (2021). High density lipoprotein-associated miRNA is increased following Roux-en-Y gastric bypass surgery for severe obesity. Journal of Lipid Research, 62. [More Information]
Cochran, B., Ong, K., Manandhar, B., Rye, K. (2021). High density lipoproteins and diabetes. Cells, 10(4). [More Information]
Ho, J., Ong, K., Cuesta Torres, L., Liu, Y., Adam, S., Iqbal, Z., Dhage, S., Ammori, B., Syed, A., Rye, K., et al (2021). High-density lipoprotein-associated miRNA is increased following Roux-en-Y gastric bypass surgery for severe obesity. Journal of Lipid Research, 62, 100043. [More Information]
Ong, K., McClelland, R., Allison, M., Cushman, M., Garg, P., Tsai, M., Rye, K., Tabet, F. (2021). Lipoprotein (a) and coronary artery calcification: prospective study assessing interactions with other risk factors. Metabolism: Clinical and Experimental, 116. [More Information]
Hui, N., Morris, M., Allison, M., Tsai, M., Rye, K., Tabet, F., Ong, K. (2021). Lipoprotein (a) and the risk of elevated depressive symptoms: The Multi-Ethnic Study of Atherosclerosis. Journal of Psychiatric Research, 133, 119-124. [More Information]
Sawant, S., Tucker, B., Senanayake, P., Waters, D., Patel, S., Rye, K., Ong, K., Cochran, B. (2021). The association between lipid levels and leukocyte count: A cross-sectional and longitudinal analysis of three large cohorts. American Heart Journal Plus: cardiology research and practice, 4. [More Information]
Tucker, B., Sawant, S., McDonald, H., Rye, K., Patel, S., Ong, K., Cochran, B. (2021). The association of serum lipid and lipoprotein levels with total and differential leukocyte counts: Results of a cross-sectional and longitudinal analysis of the UK Biobank. Atherosclerosis, 319, 1-9. [More Information]
Ong, K., Wu, L., Januszewski, A., O'Connell, R., Xu, A., Scott, R., Sullivan, D., Rye, K., Li, H., Ma, R., Li, L., Gebski, V., Jenkins, A., Keech, A., et al (2021). The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study. Diabetes and Vascular Disease Research, 18(4). [More Information]

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2020

Zhou, Z., Ong, K., Breslin, M., Allison, M., Curtis, A., Nelson, M. (2020). Association of Statin Use With Cardiovascular Outcomes by Coronary Calcium: MESA. JACC: Cardiovascular Imaging, 13(4), 1094-1096. [More Information]
Tucker, B., McClelland, R., Allison, M., Budoff, M., Wu, B., Barter, P., Rye, K., Ong, K. (2020). Relationship of fibroblast growth factor 21 levels with inflammation, lipoproteins and non-alcoholic fatty liver disease. Atherosclerosis, 299, 38-44. [More Information]
Ong, K., Wu, L., Januszewski, A., O'Connell, R., Xu, A., Rye, K., Ma, R., Li, H., Jenkins, A., Jia, W., Keech, A. (2020). Relationships of adipocyte-fatty acid binding protein and lipocalin 2 with risk factors and chronic complications in type 2 diabetes and effects of fenofibrate: A fenofibrate Intervention and event lowering in diabetes sub-study. Diabetes Research and Clinical Practice, 169, 108450. [More Information]
Ong, K., Chung, R., Hui, N., Festin, K., Lundberg, A., Rye, K., Jonasson, L., Kristenson, M. (2020). Usefulness of Certain Protein Biomarkers for Prediction of Coronary Heart Disease. American Journal of Cardiology, 125(4), 542-548. [More Information]

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2019

Hui, N., Barter, P., Ong, K., Rye, K. (2019). Altered HDL metabolism in metabolic disorders: Insights into the therapeutic potential of HDL. Clinical Science, 133(21), 2221-2235. [More Information]
Wu, B., Sun, Y., Ong, K., Li, Y., Tang, S., Barter, P., Rye, K. (2019). Apolipoprotein A-I Protects Against Pregnancy-Induced Insulin Resistance in Rats. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(6), 1160-1171. [More Information]
Hou, L., Tang, S., Wu, B., Ong, K., Westerterp, M., Barter, P., Cochran, B., Tabet, F., Rye, K. (2019). Apolipoprotein A-l improves pancreatic β-cell function independent of the ATP-binding cassette transporters ABCA1 and ABCG1. The FASEB Journal, 33(7), 8479-8489. [More Information]
Ong, K., McClelland, R., Allison, M., Kokkinos, J., Wu, B., Rye, K., Barter, P. (2019). Association of elevated circulating fibroblast growth factor 21 levels with prevalent and incident metabolic syndrome: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 281, 200-206. [More Information]
Anuwatmatee, S., Tang, S., Wu, B., Rye, K., Ong, K. (2019). Fibroblast growth factor 21 in chronic kidney disease. Clinica Chimica Acta, 489, 196-202. [More Information]
Tucker, B., Li, H., Long, X., Rye, K., Ong, K. (2019). Fibroblast growth factor 21 in non-alcoholic fatty liver disease. Metabolism: Clinical and Experimental, 101. [More Information]
Ong, K., Hui, N., Januszewski, A., Kaakoush, N., Xu, A., Fayyad, R., DeMicco, D., Jenkins, A., Keech, A., Waters, D., et al (2019). High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the treating to new targets [TNT] study). Metabolism: Clinical and Experimental, 93, 93-99. [More Information]
Anuwatmatee, S., Allison, M., Shlipak, M., McClelland, R., Kramer, H., Tang, S., Hou, L., Rye, K., Ong, K. (2019). Relationship of fibroblast growth factor 21 with kidney function and albuminuria: Multi-ethnic study of atherosclerosis. Nephrology Dialysis Transplantation, 34(6), 1009-1016. [More Information]
Ong, K., Campbell, S., Wu, B., McClelland, R., Kokkinos, J., Szklo, M., Polak, J., Allison, M., Rye, K. (2019). Relationship of fibroblast growth factor 21 with subclinical atherosclerosis and cardiovascular events: Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 287, 46-53. [More Information]
Yuan, D., Wu, B., Henry, A., Rye, K., Ong, K. (2019). Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini-review. Clinical Endocrinology, 90(1), 47-55. [More Information]
Lai, Y., Woollard, K., McClelland, R., Allison, M., Rye, K., Ong, K., Cochran, B. (2019). The association of plasma lipids with white blood cell counts: Results from the Multi-Ethnic Study of Atherosclerosis. Journal of Clinical Lipidology, 13(5), 812-820. [More Information]
Wu, B., Li, Y., Ong, K., Sun, Y., Johns, D., Barter, P., Rye, K. (2019). The Cholesteryl Ester Transfer Protein Inhibitor, des-Fluoro-Anacetrapib, Prevents Vein Bypass-induced Neointimal Hyperplasia in New Zealand White Rabbits. Scientific Reports, 9(1). [More Information]
Magdas, A., Ding, J., McClelland, R., Allison, M., Barter, P., Rye, K., Ong, K. (2019). The relationship of circulating fibroblast growth factor 21 levels with pericardial fat: The Multi-Ethnic Study of Atherosclerosis. Scientific Reports, 9(1). [More Information]

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2018

Lakhani, I., Gong, M., Wong, W., Bazoukis, G., Lampropoulos, K., Wong, S., Wu, W., Wong, M., Ong, K., Liu, T., et al (2018). Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis. Metabolism: Clinical and Experimental, 83, 11-17. [More Information]
Ong, K., Waters, D., Fayyad, R., Vogt, L., Melamed, S., DeMicco, D., Rye, K., Barter, P. (2018). Relationship of High-Density Lipoprotein Cholesterol With Renal Function in Patients Treated With Atorvastatin. Journal of the American Heart Association, 7(2), 1-7. [More Information]
Ong, K., Morris, M., McClelland, R., Hughes, T., Maniam, J., Fitzpatrick, A., Martin, S., Luchsinger, J., Rapp, S., Hayden, K., et al (2018). Relationship of Lipids and Lipid-Lowering Medications with Cognitive Function. American Journal of Epidemiology, 187(4), 767-776. [More Information]
Hui, T., McClelland, R., Allison, M., Rodriguez, C., Kronmal, R., Heckbert, S., Michos, E., Barter, P., Rye, K., Ong, K. (2018). The relationship of circulating fibroblast growth factor 21 levels with incident atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 269, 86-91. [More Information]
Choteau, S., Cuesta Torres, L., Barraclough, J., Elder, A., Martinez, G., Chen Fan, W., Shrestha, S., Ong, K., Barter, P., Celermajer, D., et al (2018). Transcoronary gradients of HDL-associated MicroRNAs in unstable coronary artery disease. International Journal of Cardiology, 253, 138-144. [More Information]

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2017

Ong, K., O'Connell, R., Januszewski, A., Jenkins, A., Xu, A., Sullivan, D., Barter, P., Scott, R., Taskinen, M., Waldman, B., Simes, R., Rye, K., Keech, A., et al (2017). Baseline circulating FGF21 concentrations and increase after fenofibrate treatment predict more rapid glycemic progression in type 2 diabetes: Results from the FIELD study. Clinical Chemistry, 63(7), 1261-1270. [More Information]
Wu, B., Li, Y., Ong, K., Sun, Y., Shrestha, S., Hou, L., Johns, D., Barter, P., Rye, K. (2017). Reduction of in-stent restenosis by cholesteryl ester transfer protein inhibition. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(12), 2333-2341. [More Information]
Kokkinos, J., Tang, S., Rye, K., Ong, K. (2017). The role of fibroblast growth factor 21 in atherosclerosis. Atherosclerosis, 257, 259-265. [More Information]

2016

Tabet, F., Torres, L., Ong, K., Shrestha, S., Choteau, S., Barter, P., Clifton, P., Rye, K. (2016). High-density lipoprotein-associated miR-223 is altered after diet-induced weight loss in overweight and obese males. PloS One, 11(3). [More Information]
Ong, K., Morris, M., McClelland, R., Maniam, J., Allison, M., Rye, K. (2016). Lipids, lipoprotein distribution and depressive symptoms: The multi-ethnic study of atherosclerosis. Translational Psychiatry, 6(11). [More Information]

2015

Wu, B., Shrestha, S., Ong, K., Johns, D., Hou, L., Barter, P., Rye, K. (2015). Cholesteryl ester transfer protein inhibition enhances endothelial repair and improves endothelial function in the rabbit. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(3), 628-636. [More Information]
Wu, H., Ong, K., Seeher, K., Armstrong, N., Thalamuthu, A., Brodaty, H., Sachdev, P., Mather, K. (2015). Circulating microRNAs as biomarkers of alzheimer's disease: A systematic review. Journal of Alzheimer's Disease, 49(3), 755-766. [More Information]
Wu, B., Shrestha, S., Ong, K., Johns, D., Dunn, L., Hou, L., Barter, P., Rye, K. (2015). Increasing HDL levels by inhibiting cholesteryl ester transfer protein activity in rabbits with hindlimb ischemia is associated with increased angiogenesis. International Journal of Cardiology, 199, 204-212. [More Information]
Ong, K., Januszewski, A., O'Connell, R., Buizen, L., Jenkins, A., Xu, A., Sullivan, D., Barter, P., Scott, R., Taskinen, M., Rye, K., Keech, A. (2015). Relationship of fibroblast growth factor 21 with baseline and new on-study microvascular disease in the Fenofibrate Intervention and Event Lowering in Diabetes study. Diabetologia, 59(8), 2035-2044. [More Information]
Ong, K., Ding, J., McClelland, R., Cheung, B., Criqui, M., Barter, P., Rye, K., Allison, M. (2015). Relationship of pericardial fat with biomarkers of inflammation and hemostasis, and cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 239(2), 386-392. [More Information]
Ong, K., Ding, J., McClelland, R., Cheung, B., Criqui, M., Barter, P., Rye, K., Allison, M. (2015). Relationship of pericardial fat with lipoprotein distribution: The Multi-Ethnic study of atherosclerosis. Atherosclerosis, 241(2), 664-670. [More Information]
Besseling, J., Ong, K., Huijgen, R., Rye, K., Hovingh, G., Hutten, B., Lambert, G. (2015). The impact of LDLR function on fibroblast growth factor 21 levels. Atherosclerosis, 241(2), 322-325. [More Information]
Ong, K., Januszewski, A., O'Connell, R., Jenkins, A., Xu, A., Sullivan, D., Barter, P., Hung, W., Scott, R., Taskinen, M., Keech, A., Rye, K. (2015). The relationship of fibroblast growth factor 21 with cardiovascular outcome events in the Fenofibrate Intervention and Event Lowering in Diabetes study. Diabetologia, 58(3), 464-473. [More Information]

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2014

Cheung, C., Hui, E., Cheung, B., Woo, Y., Xu, A., Fong, C., Ong, K., Yeung, C., Janus, E., Tse, H., et al (2014). Adiponectin gene variants and the risk of coronary heart disease: A 16-year longitudinal study. European Journal of Endocrinology, 171(1), 107-115. [More Information]
Ong, K., Barter, P., Waters, D. (2014). Cardiovascular drugs that increase the risk of new-onset diabetes. American Heart Journal, 167(4), 421-428. [More Information]
Ong, K., Waters, D., Messig, M., DeMicco, D., Rye, K., Barter, P. (2014). Effect of Change in Body Weight on Incident Diabetes Mellitus in Patients With Stable Coronary Artery Disease Treated With Atorvastatin (from the Treating to New Targets Study). American Journal of Cardiology, 113(10), 1593-1598. [More Information]
Wu, B., Ong, K., Shrestha, S., Chen, K., Tabet, F., Barter, P., Rye, K. (2014). Inhibition of Arthritis in the Lewis Rat by Apolipoprotein A-I and Reconstituted High-Density Lipoproteins. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(3), 543-551. [More Information]
Ong, K., McClelland, R., Rye, K., Cheung, B., Post, W., Vaidya, D., Criqui, M., Cushman, M., Barter, P., Allison, M. (2014). The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis, 236(2), 257-262. [More Information]
Ong, K., Allison, M., Cheung, B., Wu, B., Barter, P., Rye, K. (2014). The Relationship between Total Bilirubin Levels and Total Mortality in Older Adults: The United States National Health and Nutrition Examination Survey (NHANES) 1999-2004. PloS One, 9(14), 1-8. [More Information]
Wong, H., Ong, K., cheung, C., Cheung, B. (2014). Utilization of glucose, blood pressure, and lipid lowering medications among people with type II diabetes in the United States, 1999-2010. Annals of Epidemiology, 24(7), 516-521. [More Information]

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2013

Wong, H., Ong, K., Leung, R., Lam, T., Thomas, G., Lam, K., Cheung, B. (2013). A single nucleotide polymorphism of interleukin-6 gene is related to plasma adrenomedullin levels. Clinical Endocrinology, 79(4), 504-509. [More Information]
Ong, K., Wu, B., Cheung, B., Barter, P., Rye, K. (2013). Arthritis: Its prevalence, risk factors, and association with cardiovascular diseases in the United States, 1999 to 2008. Annals of Epidemiology, 23(2), 80-86. [More Information]
Wu, B., Chen, K., Shrestha, S., Ong, K., Barter, P., Rye, K. (2013). High Density Lipoproteins Inhibit Vascular Endothelial Inflammation by Increasing 3[beta]-Hydroxysteroid-{Delta}24 Reductase Expression and Inducing Heme Oxygenase-1. Circulation Research, 112(2), 278-288. [More Information]
Wong, H., Ong, K., Leung, R., Cheung, T., Xu, A., Lam, T., Lam, K., Cheung, B. (2013). Plasma Level of Adrenomedullin Is Influenced by a Single Nucleotide Polymorphism in the Adiponectin Gene. PloS One, 8(8). [More Information]
Ong, K., Allison, M., Cheung, B., Wu, B., Barter, P., Rye, K. (2013). Trends in C-Reactive Protein Levels in US Adults From 1999 to 2010. American Journal of Epidemiology, 177(12), 1430-1442. [More Information]

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2012

Ong, K., Rye, K., O'Connell, R., Jenkins, A., Brown, C., Xu, A., Sullivan, D., Barter, P., Keech, A. (2012). Long-Term Fenofibrate Therapy Increases Fibroblast Growth Factor 21 and Retinol-Binding Protein 4 in Subjects with Type 2 Diabetes. Journal of Clinical Endocrinology and Metabolism, 97(12), 4701-4708. [More Information]

2011

Ong, K., Wu, B., Cheung, B., Barter, P., Rye, K. (2011). Association of lower total bilirubin level with statin usage: The United States National Health and Nutrition Examination Survey 1999-2008. Atherosclerosis, 219(2), 728-733. [More Information]
Ong, K., Tso, A., Xu, A., Law, L., Li, M., Wat, N., Rye, K., Lam, T., Cheung, B., Lam, K. (2011). Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years. Diabetologia, 54(10), 2552-2560. [More Information]

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Dr Kwok Leung Ong

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