2024

• Veronese, N., Notarnicola, M., Giannelli, G., De Pergola, G., Stamatakis, E., Cereda, E., Bernardinelli, L., Fontana, L., Nova, A., Fazia, T., Piccio, L., Huang, B., Ahmadi, M., et al (2024). Contribution of Nutritional, Lifestyle, and Metabolic Risk Factors to Parkinson's Disease. Movement Disorders, 39(7), 1203-1212. [More Information]
• Shi, L., Ghezzi, L., Fenoglio, C., Pietroboni, A., Galimberti, D., Pace, F., Hardy, T., Piccio, L., Don, A. (2024). CSF sphingolipids are correlated with neuroinflammatory cytokines and differentiate neuromyelitis optica spectrum disorder from multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 96(1), 54-67. [More Information]
• Martin, K., Ghezzi, L., Green, K., Pace, F., Pastori, G., Taylor, M., Piccio, L., Wingo, B., Cofield, S., Cross, A., et al (2024). Functional outcomes of diets in multiple sclerosis (FOOD for MS): Protocol for a parallel arm randomized feeding trial for low glycemic load and calorie restriction. Contemporary Clinical Trials, 143, 107584. [More Information]
• Ni, D., Tan, J., Reyes, J., Senior, A., Andrews, C., Taitz, J., Potier, C., Wishart, C., Spiteri, A., Piccio, L., King, N., Simpson, S., Nanan, R., Macia, L. (2024). High fat low carbohydrate is linked to protection against the development of CNS autoimmunity. European Journal of Immunology, 54(1), 230-230. [More Information]
• Lin, Q., Dorsett, Y., Mirza, A., Tremlett, H., Piccio, L., Longbrake, E., Choileain, S., Hafler, D., Cox, L., Weiner, H., et al (2024). Meta-analysis identifies common gut microbiota associated with multiple sclerosis. Genome Medicine, 16(1). [More Information]
• Rahmani, F., Mittendorfer, B., Piccio, L., Raji, C., Ghezzi, L., Tosti, V., Liu, J., Song, S., Wu, A., Rajamanickam, J., et al (2024). Twelve Weeks of Intermittent Caloric Restriction Diet Mitigates Neuroinflammation in Midlife Individuals with Multiple Sclerosis: A Pilot Study with Implications for Prevention of Alzheimer's Disease. Advances in Alzheimer's Disease, 11, 156-166. [More Information]

2023

• Touil, H., Li, R., Zuroff, L., Moore, C., Healy, L., Cignarella, F., Piccio, L., Ludwin, S., Prat, A., Gommerman, J., et al (2023). Cross-talk between B cells, microglia and macrophages, and implications to central nervous system compartmentalized inflammation and progressive multiple sclerosis. EBioMedicine, 96. [More Information]
• Filipello, F., You, S., Mirfakhar, F., Mahali, S., Bollman, B., Acquarone, M., Korvatska, O., Marsh, J., Sivaraman, A., Martinez, R., Piccio, L., et al (2023). Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta Neuropathologica, 145(6), 749-772. [More Information]
• Teo, J., Marian, O., Spiteri, A., Nicholson, M., Song, H., Khor, J., McEwen, H., Ge, A., Sen, M., Piccio, L., King, N., Don, A., et al (2023). Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. GLIA, 71(4), 1120-1141. [More Information]
• Sen, M., Ge, A., Liao, E., Gard, H., Ni, D., Macia, L., Piccio, L. (2023). Impact of a high fibre diet on immune cells and the multiple sclerosis animal model. Journal of Immunology, 210(Suppl 1). [More Information]
• Demaria, M., Bertozzi, B., Veronese, N., Spelta, F., Cava, E., Tosti, V., Piccio, L., Early, D., Fontana, L. (2023). Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults. npj Aging, 9(1). [More Information]
• Samara, A., Cantoni, C., Piccio, L., Cross, A., Chahin, S. (2023). Obesity, gut microbiota, and multiple sclerosis: Unraveling the connection. Multiple Sclerosis and Related Disorders, 76. [More Information]
• Ghezzi, L., Bollman, B., De Feo, L., Piccio, L., Trapp, B., Schmidt, R., Cross, A. (2023). Schwann Cell Remyelination in the Multiple Sclerosis Central Nervous System. Laboratory Investigation, 103(6). [More Information]
• Brenton, J., Piccio, L. (2023). Strengthening the link: Diet quality and disability in MS. Multiple Sclerosis Journal, 29(2), 157-159. [More Information]
• Cantoni, C., Ghezzi, L., Choi, J., Cross, A., Piccio, L. (2023). Targeting miR-223 enhances myeloid-derived suppressor cell suppressive activities in multiple sclerosis patients. Multiple Sclerosis and Related Disorders, 76. [More Information]
• Cardamone, G., Paraboschi, E., Soldà, G., Liberatore, G., Rimoldi, V., Cibella, J., Airi, F., Tisato, V., Cantoni, C., Gallia, F., Piccio, L., et al (2023). The circular RNA landscape in multiple sclerosis: Disease-specific associated variants and exon methylation shape circular RNA expression profile. Multiple Sclerosis and Related Disorders, 69. [More Information]
• Spain, R., Piccio, L., Langer-Gould, A. (2023). The Role of Diet in Multiple Sclerosis: Food for Thought. Neurology, 100(4), 167-168. [More Information]
• Holloman, J., Dimas, S., Archambault, A., Filipello, F., Du, L., Feng, J., Zhao, Y., Bollman, B., Piccio, L., Steelman, A., et al (2023). Transient Receptor Potential Vanilloid 4-Dependent Microglial Function in Myelin Injury and Repair. International Journal of Molecular Sciences, 24(23). [More Information]
• Rahmani, F., Ghezzi, L., Tosti, V., Liu, J., Song, S., Wu, A., Rajamanickam, J., Obert, K., Benzinger, T., Mittendorfer, B., Piccio, L., et al (2023). Twelve Weeks of Intermittent Caloric Restriction Diet Mitigates Neuroinflammation in Midlife Individuals with Multiple Sclerosis: A Pilot Study with Implications for Prevention of Alzheimer's Disease. Journal of Alzheimer's Disease, 93(1), 263-273. [More Information]

2022

• Esposito, F., Osiceanu, A., Sorosina, M., Ottoboni, L., Bollman, B., Santoro, S., Bettegazzi, B., Zauli, A., Clarelli, F., Mascia, E., Piccio, L., et al (2022). A Whole-Genome Sequencing Study Implicates GRAMD1B in Multiple Sclerosis Susceptibility. Genes, 13(12). [More Information]
• Veronese, N., Yang, L., Piccio, L., Smith, L., Firth, J., Marx, W., Giannelli, G., Caruso, M., Cisternino, A., Notarnicola, M., Fontana, L., et al (2022). Adherence to a healthy lifestyle and multiple sclerosis: a case–control study from the UK Biobank. Nutritional Neuroscience, 25(6), 1231-1239. [More Information]
• Cantoni, C., Lin, Q., Dorsett, Y., Ghezzi, L., Liu, Z., Pan, Y., Chen, K., Han, Y., Li, Z., Xiao, H., Piccio, L., et al (2022). Alterations of host-gut microbiome interactions in multiple sclerosis. EBioMedicine, 76. [More Information]
• Yang, L., Veronese, N., Harper, A., Piccio, L., Twigg, S., Fontana, L. (2022). Calorie restriction causes multiple beneficial metabolic adaptations linearly related with the degree of weight loss in non-obese individuals: Results of CALERIE, a multicenter randomised controlled trial. Nutrition and Healthy Aging, 7(1-2), 75-85. [More Information]
• Cantoni, C., Dorsett, Y., Fontana, L., Zhou, Y., Piccio, L. (2022). Effects of dietary restriction on gut microbiota and CNS autoimmunity. Clinical Immunology, 235, 108575. [More Information]
• Filipello, F., Goldsbury, C., You, S., Locca, A., Karch, C., Piccio, L. (2022). Soluble TREM2: Innocent bystander or active player in neurological diseases? Neurobiology of Disease, 165, 105630. [More Information]

2021

• Piccio, L., Wu, G., Klein, R. (2021). A new era in neuroimmunology. Journal of Neuroimmunology, 351, 577478. [More Information]
• Schindler, S., Cruchaga, C., Joseph, A., McCue, L., Farias, F., Wilkins, C., Deming, Y., Henson, R., Mikesell, R., Piccio, L., et al (2021). African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants. Neurology: Genetics, 7(2), 1-12. [More Information]
• Shah, S., Locca, A., Dorsett, Y., Cantoni, C., Ghezzi, L., Lin, Q., Bokoliya, S., Panier, H., Suther, C., Gormley, M., Piccio, L., et al (2021). Alterations of the gut mycobiome in patients with MS. EBioMedicine, 71, 103557. [More Information]
• Fontana, L., Ghezzi, L., Cross, A., Piccio, L. (2021). Effects of dietary restriction on neuroinflammation in neurodegenerative diseases. The Journal of Experimental Medicine, 218(2), e20190086-1-e20190086-14. [More Information]
• Ghezzi, L., Cantoni, C., Pinget, G., Zhou, Y., Piccio, L. (2021). Targeting the gut to treat multiple sclerosis. Journal of Clinical Investigation, 131(13), e143774-1-e143774-14. [More Information]

2020

• Ewers, M., Biechele, G., Suárez-Calvet, M., Sacher, C., Blume, T., Morenas-Rodríguez, E., Deming, Y., Piccio, L., Crane, P., Kleinberger, G., et al (2020). Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. EMBO Molecular Medicine, 12(9), 1-14. [More Information]
• Ghezzi, L., Cantoni, C., Cignarella, F., Bollman, B., Cross, A., Salter, A., Galimberti, D., Cella, M., Piccio, L. (2020). T cells producing GM-CSF and IL-13 are enriched in the cerebrospinal fluid of relapsing MS patients. Multiple Sclerosis Journal, 26(10), 1172-1186. [More Information]
• Cignarella, F., Filipello, F., Bollman, B., Cantoni, C., Locca, A., Mikesell, R., Manis, M., Ibrahim, A., Deng, L., Benitez, B., Buckland, M., Piccio, L., et al (2020). TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathologica, 140(4), 513-534. [More Information]

2019

• Evans, E., Levasseur, V., Cross, A., Piccio, L. (2019). An overview of the current state of evidence for the role of specific diets in multiple sclerosis. Multiple Sclerosis and Related Disorders, 36, 1-6. [More Information]
• Jordan, S., Tung, N., Casanova-Acebes, M., Chang, C., Cantoni, C., Zhang, D., Wirtz, T., Naik, S., Rose, S., Brocker, C., Piccio, L., et al (2019). Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. Cell, 178(5), 1102-1114.e17. [More Information]
• Suarez-Calvet, M., Morenas-Rodríguez, E., Kleinberger, G., Schlepckow, K., Caballero, M., Franzmeier, N., Capell, A., Fellerer, K., Nuscher, B., Piccio, L., et al (2019). Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-â pathology. Molecular Neurodegeneration, 14(1), 1. [More Information]
• Ewers, M., Franzmeier, N., Suárez-Calvet, M., Morenas-Rodríguez, E., Caballero, M., Kleinberger, G., Piccio, L., Crane, P., Deming, Y., Dichgans, M., et al (2019). Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science Translational Medicine, 11(507), 1-13. [More Information]
• Galimberti, D., Fenoglio, C., Ghezzi, L., Serpente, M., Arcaro, M., D'Anca, M., De Riz, M., Arighi, A., Fumagalli, G., Pietroboni, A., et al (2019). Inflammatory expression profile in peripheral blood mononuclear cells from patients with Nasu-Hakola Disease. Cytokine, 116, 115-119. [More Information]
• Cardamone, G., Paraboschi, E., Solda, G., Cantoni, C., Supino, D., Piccio, L., Duga, S., Asselta, R. (2019). Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis. Human Molecular Genetics, 28(9), 1414-1428. [More Information]
• Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J., Dube, U., Farias, F., Piccio, L., et al (2019). The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Science Translational Medicine, 11(505), 1-18. [More Information]

2018

• Suarez-Calvet, M., Capell, A., Caballero, M., Morenas-Rodríguez, E., Fellerer, K., Franzmeier, N., Kleinberger, G., Eren, E., Deming, Y., Piccio, L., et al (2018). CSF progranulin increases in the course of Alzheimer’s disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO Molecular Medicine, 10(12), e9712. [More Information]
• Longbrake, E., Cantoni, C., Chahin, S., Cignarella, F., Cross, A., Piccio, L. (2018). Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count. Multiple Sclerosis Journal, 24(6), 728-738. [More Information]
• Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L., Phillips, D., Weinstock, G., Fontana, L., Cross, A., et al (2018). Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota. Cell Metabolism, 27(6), 1222-1235. [More Information]
• Warikoo, N., Brunwasser, S., Benz, A., Shu, H., Paul, S., Lewis, M., Doherty, J., Quirk, M., Piccio, L., Zorumski, C., et al (2018). Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis. Journal of Neuroscience, 38(13), 3218-3229. [More Information]
• Filipello, F., Morini, R., Corradini, I., Zerbi, V., Canzi, A., Michalski, B., Erreni, M., Markicevic, M., Starvaggi-Cucuzza, C., Otero, K., et al (2018). The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity. Immunity, 48(5), 979-991. [More Information]
• Evans, E., Piccio, L., Cross, A. (2018). Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis A Review. JAMA Neurology, 75(8), 1013-1021. [More Information]

2017

• Cantoni, C., Cignarella, F., Ghezzi, L., Mikesell, B., Bollman, B., Berrien-Elliott, M., Ireland, A., Fehniger, T., Wu, G., Piccio, L. (2017). Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Acta Neuropathologica, 133(1), 61-77. [More Information]
• Klein, R., Voskuhl, R., Segal, B., Dittel, B., Lane, T., Bethea, J., Carson, M., Colton, C., Rosi, S., Anderson, A., et al (2017). Speaking out about gender imbalance in invited speakers improves diversity. Nature Immunology, 18(5), 475-478. [More Information]

2016

• Choi, I., Piccio, L., Childress, P., Bollman, B., Ghosh, A., Brandhorst, S., Suarez, J., Michalsen, A., Cross, A., Morgan, T., et al (2016). A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Reports, 15(10), 2136-2146. [More Information]
• Piccio, L., Deming, Y., Del‑Aguila, J., Ghezzi, L., Holtzman, D., Fagan, A., Fenoglio, C., Galimberti, D., Borroni, B., Cruchaga, C. (2016). Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status. Acta Neuropathologica, 131(6), 925-933. [More Information]
• Longbrake, E., Ramsbottom, M., Cantoni, C., Ghezzi, L., Cross, A., Piccio, L. (2016). Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients. Multiple Sclerosis Journal, 22(8), 1061-1070. [More Information]
• Deming, Y., Xia, J., Cai, Y., Lord, J., Del-Aguila, J., Fernandez, M., Carrell, D., Black, K., Budde, J., Ma, S., et al (2016). Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits. Scientific Reports, 6. [More Information]

2015

• Isobe, N., Madireddy, L., Khankhanian, P., Matsushita, T., Caillier, S., Moré, J., Gourraud, P., McCauley, J., Beecham, A., Piccio, L., et al (2015). An ImmunoChip study of multiple sclerosis risk in African Americans. Brain, 138(6), 1518-1530. [More Information]
• Patel, K., Luo, J., Alvarez, E., Piccio, L., Schmidt, R., Yablonskiy, D., Cross, A. (2015). Detection of cortical lesions in multiple sclerosis: A new imaging approach. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 1, 1-4. [More Information]
• Alvarez, E., Piccio, L., Mikesell, R., Trinkaus, K., Parks, B., Naismith, R. (2015). Predicting optimal response to B-cell depletion with rituximab in multiple sclerosis using CXCL13 index, magnetic resonance imaging and clinical measures. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 1. [More Information]
• Cantoni, C., Bollman, B., Licastro, D., Xie, M., Mikesell, R., Schmidt, R., Yuede, C., Galimberti, D., Olivecrona, G., Klein, R., et al (2015). TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta Neuropathologica, 129(3), 429-447. [More Information]

2014

• Ulrich, J., Finn, M., Wang, Y., Shen, A., Mahan, T., Jiang, H., Stewart, F., Piccio, L., Colonna, M., Holtzman, D. (2014). Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2. Molecular Neurodegeneration, 9(1). [More Information]
• Cruz-Orengo, L., Daniels, B., Dorsey, D., Basak, S., Grajales-Reyes, J., McCandless, E., Piccio, L., Schmidt, R., Cross, A., Crosby, S., et al (2014). Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. Journal of Clinical Investigation, 124(6), 2571-2584. [More Information]

2013

• Alvarez, E., Piccio, L., Mikesell, R., Klawiter, E., Parks, B., Naismith, R., Cross, A. (2013). CXCL13 is a biomarker of inflammation in multiple sclerosis, neuromyelitis optica, and other neurological conditions. Multiple Sclerosis Journal, 19(9), 1204-1208. [More Information]
• Fenoglio, C., Ridolfi, E., Cantoni, C., De Riz, M., Bonsi, R., Serpente, M., Villa, C., Pietroboni, A., Naismith, R., Alvarez, E., et al (2013). Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis. Multiple Sclerosis Journal, 19(14), 1938-1942. [More Information]
• Isobe, N., Gourraud, P., Harbo, H., Caillier, S., Santaniello, A., Khankhanian, P., Maiers, M., Spellman, S., Cereb, N., Yang, S., et al (2013). Genetic risk variants in African Americans with multiple sclerosis. Neurology, 81(3), 219-227. [More Information]
• Piccio, L., Cantoni, C., Henderson, J., Hawiger, D., Ramsbottom, M., Mikesell, R., Ryu, J., Hsieh, C., Cremasco, V., Haynes, W., et al (2013). Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis. European Journal of Immunology, 43(8), 2089-2100. [More Information]
• Bock, V., Botturi, A., Gaviani, P., Lamperti, E., MacCagnano, C., Piccio, L., Silvani, A., Salmaggi, A. (2013). Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (PLOSL): A new report of an Italian woman and review of the literature. Journal of the Neurological Sciences, 326(1-2), 115-119. [More Information]
• Angiari, S., Rossi, B., Piccio, L., Zinselmeyer, B., Budui, S., Zenaro, E., Della Bianca, V., Bach, S., Scarpini, E., Bolomini-Vittori, M., et al (2013). Regulatory T cells suppress the late phase of the immune response in lymph nodes through P-selectin glycoprotein ligand-1. Journal of Immunology, 191(11), 5489-5500. [More Information]