People_
Professor Laurence Macia
Academic Director Sydney Cytometry
Nutritional Immunometabolism Lab
Heada Beckett Fellow
School of Medical Sciences
Faculty of Medicine and Health
Nutritional Immunometabolism Lab
Heada Beckett Fellow
School of Medical Sciences
Faculty of Medicine and Health
Details
Member of The University of Sydney Nano Institute
Member of the Charles Perkins Centre
Obesity, Diabetes and Cardiovascular Disease, Infection and Immunological Conditions, Reproductive, Maternal and Child Health
Project title | Research student |
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Investigating the effects of high-fibre diet and its combination with intermittent fasting in an animal model of multiple sclerosis | Anjie GE |
The role of the maternal gut microbiota on the immune homeostasis of the offspring | Camille POTIER |
Investigation of host-microbiota communication through diverse signalling pathways | Jemma TAITZ |
Publications
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Book Chapters
- Xiang, M., Tan, J., Macia, L. (2019). Fatty Acids, Gut Bacteria, and Immune Cell Function. In Not known (Eds.), The Molecular Nutrition of Fats, (pp. 151-164). TBC. [More Information]
Journals
- Taitz, J., Tan, J., Ni, D., Potier, C., Grau, G., Nanan, R., Macia, L. (2025). Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways. Frontiers in Immunology, 15, 1493991. [More Information]
- Ni, D., Senior, A., Tan, J., Macia, L., Nanan, R. (2024). Linking Macronutrient Composition of Common Allergenic Foods to European and North American Food Allergy Prevalence. Clinical and Experimental Allergy. [More Information]
- Spiteri, A., Wishart, C., Pinget, G., Purohit, S., Macia, L., King, N., Niewold, P. (2024). NK cell profiling in West Nile virus encephalitis reveals potential metabolic basis for functional inhibition. Immunology and Cell Biology. [More Information]
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2025
- Taitz, J., Tan, J., Ni, D., Potier, C., Grau, G., Nanan, R., Macia, L. (2025). Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways. Frontiers in Immunology, 15, 1493991. [More Information]
2024
- Ni, D., Senior, A., Tan, J., Macia, L., Nanan, R. (2024). Linking Macronutrient Composition of Common Allergenic Foods to European and North American Food Allergy Prevalence. Clinical and Experimental Allergy. [More Information]
- Spiteri, A., Wishart, C., Pinget, G., Purohit, S., Macia, L., King, N., Niewold, P. (2024). NK cell profiling in West Nile virus encephalitis reveals potential metabolic basis for functional inhibition. Immunology and Cell Biology. [More Information]
- Ribeiro, R., Senior, A., Simpson, S., Tan, J., Raubenheimer, D., Le Couteur, D., Macia, L., Holmes, A., Eberhard, J., O'Sullivan, J., Koay, Y., Kanjrawi, A., Yang, J., Kim, T., Gosby, A. (2024). Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial. Aging Cell. [More Information]
2023
- Wali, J., Ni, D., Facey, H., Dodgson, T., Pulpitel, T., Senior, A., Raubenheimer, D., Macia, L., Simpson, S. (2023). Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice. Nature Communications, 14(1). [More Information]
- Tan, J., Macia, L., Mackay, C. (2023). Dietary fiber and SCFAs in the regulation of mucosal immunity. Journal of Allergy and Clinical Immunology, 151(2), 361-370. [More Information]
- Sen, M., Ge, A., Liao, E., Gard, H., Ni, D., Macia, L., Piccio, L. (2023). Impact of a high fibre diet on immune cells and the multiple sclerosis animal model. Journal of Immunology, 210(Suppl 1). [More Information]
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2022
- Eberhard, J., Ruiz, K., Tan, J., Vidanelage, T., Khan, S., Inan Eroglu, E., Adler, C., Simpson, S., Le Couteur, D., Raubenheimer, D., Macia, L., Gosby, A., Ribeiro, R. (2022). A randomized clinical trial to investigate the effect of dietary protein sources on periodontal health. Journal of Clinical Periodontology, 49(4), 388-400. [More Information]
- Rempenault, C., Mielle, J., Schreiber, K., Corbeau, P., Macia, L., Combe, B., Morel, J., Daien, C., Audo, R. (2022). CXCR5/CXCL13 pathway, a key driver for migration of regulatory B10 cells, is defective in patients with rheumatoid arthritis. Rheumatology, 61(5), 2185-2196. [More Information]
- Simpson, R., Shanahan, E., Batten, M., Reijers, I., Read, M., Da Silva, I., Versluis, J., Ribeiro, R., Angelatos, A., Tan, J., Adhikari, C., Menzies, A., Saw, R., Gonzalez, M., Shannon, K., Spillane, A., Velickovic, R., Macia, L., Holmes, A., Wilmott, J., Scolyer, R., Long, G., et al (2022). Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome. Nature Medicine, 28(11), 2344-2352. [More Information]
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2021
- Tan, J., Ni, D., Wali, J., Cox, D., Pinget, G., Taitz, J., Daien, C., Senior, A., Read, M., Simpson, S., King, N., Macia, L. (2021). Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function. iScience, 24(8), 102835. [More Information]
- Macia, L., Galy, O., Nanan, R. (2021). Editorial: Modern Lifestyle and Health: How Changes in the Environment Impacts Immune Function and Physiology. Frontiers in Immunology, 12, 762166. [More Information]
- Liu, Y., Li, Y., Loh, Y., Singer, J., Zhu, W., Macia, L., Mackay, C., Wang, W., Chadban, S., Wu, H. (2021). Fiber Derived Microbial Metabolites Prevent Acute Kidney Injury Through G-Protein Coupled Receptors and HDAC Inhibition. Frontiers in Cell and Developmental Biology, 9, 648639. [More Information]
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2020
- Li, Y., Chen, X., Kwan, T., Loh, Y., Singer, J., Liu, Y., Ma, J., Tan, J., Macia, L., Mackay, C., Chadban, S., Wu, H. (2020). Dietary fiber protects against diabetic nephropathy through short-chain fatty acid-mediated activation of G protein-coupled receptors GPR43 and GPR109A. Journal of the American Society of Nephrology, 31(6), 1267-1281. [More Information]
- Wu, H., Singer, J., Kwan, T., Loh, Y., Wang, C., Tan, J., Li, Y., Lai, S., Macia, L., Alexander, S., Chadban, S. (2020). Gut microbial metabolites induce donor-specific tolerance of kidney allografts through induction of T regulatory cells by short-chain fatty acids. Journal of the American Society of Nephrology, 31(7), 1445-1461. [More Information]
- Macia, L., Nanan, R., Hosseini Beheshti, E., Grau, G. (2020). Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development. International Journal of Molecular Sciences, 21(1), 1-18. [More Information]
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2019
- Hu, M., Eviston, D., Hsu, P., Marino, E., Chidgey, A., Nanan, B., Wong, K., Richards, J., Yap, Y., Collier, F., Quinton, A., Joung, S., Peek, M., Benzie, R., Macia, L., Nanan, R., et al (2019). Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia. Nature Communications, 10(1), 1-13. [More Information]
- Macia, L., Mackay, C. (2019). Dysfunctional microbiota with reduced capacity to produce butyrate as a basis for allergic diseases. Journal of Allergy and Clinical Immunology, 144(6), 1513-1515. [More Information]
- Xiang, M., Tan, J., Macia, L. (2019). Fatty Acids, Gut Bacteria, and Immune Cell Function. In Not known (Eds.), The Molecular Nutrition of Fats, (pp. 151-164). TBC. [More Information]
show 3 more
2018
- Mielle, J., Audo, R., Hahne, M., Macia, L., Combe, B., Daien, C. (2018). IL-10 producing B cells ability to induce regulatory T cells is maintained in rheumatoid arthritis. Frontiers in Immunology, 9(MAY), 1-11. [More Information]
- Simpson, S., Raubenheimer, D., Cogger, V., Macia, L., Solon-Biet, S., Le Couteur, D., George, J. (2018). The nutritional geometry of liver disease including non-alcoholic fatty liver disease (NAFLD). Journal of Hepatology, 68(2), 316-325. [More Information]
2017
- Daien, C., Pinget, G., Tan, J., Macia, L. (2017). Detrimental impact of microbiota-accessible carbohydrate-deprived diet on gut and immune homeostasis: An overview. Frontiers in Immunology, 8, 1-7. [More Information]
- Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M., Konijn, T., Knippenberg, M., Cook, E., Hanekamp, D., et al (2017). Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells. Journal of Immunology, 198(5), 2172-2181. [More Information]
- Vieira, A., Galvao, I., Macia, L., Sernaglia, E., Vinolo, M., Garcia, C., Tavares, L., Amaral, F., Sousa, L., et al (2017). Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. Journal of Leukocyte Biology, 101(1), 275-284. [More Information]
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2016
- Chevalier, N., Tan, J., Mason, L., Robert, R., McKenzie, C., Lim, F., Wong, C., Macia, L., Thorburn, A., Russ, B., et al (2016). Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges. Journal of Autoimmunity, 73, 120-129. [More Information]
- Tan, J., McKenzie, C., Vuillermin, P., Goverse, G., Vinuesa, C., Mebius, R., Macia, L., Mackay, C. (2016). Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Reports, 15(12), 2809-2824. [More Information]
- Lassen, K., McKenzie, C., Mari, M., Murano, T., Begun, J., Baxt, L., Goel, G., Villablanca, E., Kuo, S., Macia, L., et al (2016). Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk. Immunity, 44(6), 1392-1405. [More Information]
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2015
- Vieira, A., Macia, L., Galvao, I., Martins, F., Canesso, M., Amaral, F., Garcia, C., Maslowski, K., De Leon, E., Shim, D., et al (2015). A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout. Arthritis & Rheumatology, 67(6), 1646-1656. [More Information]
- Thorburn, A., McKenzie, C., Shen, S., Stanley, D., Macia, L., Mason, L., Roberts, L., Wong, C., Shim, R., Robert, R., Mackay, C., et al (2015). Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nature Communications, 6, 1-13. [More Information]
- McKenzie, C., Mackay, C., Macia, L. (2015). GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases. Trends in Endocrinology and Metabolism, 26(10), 511-512. [More Information]
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2014
- Thorburn, A., Macia, L., Mackay, C. (2014). Diet, metabolites, and "western-lifestyle" inflammatory diseases. Immunity, 40(6), 833-42. [More Information]
- Nguyen, A., Slack, K., Schwarzer, C., Lee, N., Boey, D., Macia, L., Yulyaningsih, E., Enriquez, R., Zhang, L., Lin, S., Salis (nee Sainsbury), A., et al (2014). Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides, 48(3), 143-151. [More Information]
- Chevalier, N., Thorburn, A., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P., Mackay, C. (2014). Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion. Journal of Immunology, 193(10), 4845-5488. [More Information]
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2013
- Tsai, V., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jorgensen, S., Lee-Ng, K., Zhang, H., Wu, L., Marquis, C., Salis (nee Sainsbury), A., et al (2013). TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. PloS One, 8(2), 1-10. [More Information]
2012
- Lucas, S., Taront, S., Magnan, C., Fauconnier, L., Delacre, M., Macia, L., Verwaerde, C., Spriet, C., Saule, P., Goormachtigh, G., et al (2012). Interleukin-7 regulates adipose tissue mass and insulin sensitivity in high-fat diet-fed mice through lymphocyte-dependent and independent mechanisms. PloS One, 7(6), e40351-0. [More Information]
- Macie, L., Tsai, V., Nguyen, A., Johnen, H., Kuffner, T., Shi, Y., Lin, S., Herzog, H., Brown, D., Breit, S., Salis (nee Sainsbury), A. (2012). Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets. PloS One, 7(4), 1-8. [More Information]
- Macia, L., Thorburn, A., Binge, L., Marino, E., Rogers, K., Maslowski, K., Vieira, A., Kranich, J., Mackay, C. (2012). Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunological Reviews, 245(1), 164-176. [More Information]
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2011
- Shi, Y., Lin, S., Castillo, L., Aljanova, A., Enriquez, R., Nguyen, A., Baldock, P., Zhang, L., Bijker, M., Macia, L., Salis (nee Sainsbury), A., et al (2011). Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet-Induced Obesity. Obesity, 19(11), 2137-7148. [More Information]
- Macia, L., Rao, P., Wheway, J., Sierro, F., Mackay, F., Herzog, H. (2011). Y1 signalling has a critical role in allergic airway inflammation. Immunology and Cell Biology, 89(8), 882-888. [More Information]
2010
- Shi, Y., Lin, S., Wong, I., Baldock, P., Aljanova, A., Enriquez, R., Castillo, L., Mitchell, N., Ye, J., Zhang, L., Salis (nee Sainsbury), A., et al (2010). NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice. PloS One, 5(6), 1-16. [More Information]
2009
- Lin, S., Shi, Y., Yulyaningsih, E., Aljanova, A., Zhang, L., Macia, L., Nguyen, A., Lin, E., During, M., Herzog, H., Salis (nee Sainsbury), A. (2009). Critical role of arcuate y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PloS One, 4(12), e8488-e8488. [More Information]
Selected Grants
2020
- The maternal gut microbiota drives foetal Thymic T cell development, Nanan R, Macia L, Grau G, King N, Australian Research Council (ARC)/Discovery Projects (DP)
2019
- Role of butyrate in intermittent fasting-induced protection in a multiple sclerosis animal model, Macia L, Piccio L, Multiple Sclerosis Research Australia/Incubator Grant
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