People_

Professor Mark Molloy

PhD

Lawrence Penn Chair of Bowel Cancer Research
School of Medical Sciences
Faculty of Medicine and Health

Phone

9926 7870

m.molloy@sydney.edu.au

Mark completed his BSc(Hons) in the School of Biological Sciences at Macquarie University in 1995, then conducted his PhD research in the emerging field of proteomics with Professor Keith Williams in 2000. Mark moved to the USA for post-doctoral training in mass spectrometry with Professor Philip Andrews at the University of Michigan Medical School. Subsequently, Mark took a research scientist role in Pfizer Inc, using proteomics to discovery biomarkers of drug response and drug differentiation. Mark returned to Australia to take up an NHMRC Biomedical career development award to apply proteomics to investigate prognostic and predictive biomarkers associated with colorectal cancer. For this research he ustilised the proteomic infrastructure at the Australian Proteome Analysis Facility (APAF) at Macquarie University where he was appointed as Associate Professor. In 2010, Mark was appointed as APAF Director, leading a 20+ research team to apply proteomics in the life-sciences collaborating with academic and industry partners. Mark was interim Head of the Department of Chemistry and Biomolecular Sciences for 18 months until Feb 2017. In March 2018 he was selected as the inaugural Lawrence Penn Chair of Bowel Cancer Research at the Sydney Medical School, Northern Clinical School, RNSH campus.

Research interests

Biomarkers, cancers, protein phosphorylation, mass spectrometry, proteomics, translational research, bowel cancer

Current projects

Proteomic landscapes of bowel cancers subtypes

Molecular analysis of polyps and early stage bowel cancer development

Role of microbiota/microbiome in bowel cancer development and recurrence

Oncology drug response prediction using mass spectrometry

Associations

Australasian Proteomics Society (APS)

American Association Cancer Research (AACR)

American Society Mass Spectrometry (ASMS)

Human Proteome Organisation (HUPO)

American Society for Biochemistry and Molecular Biology (ASBMB)

Australian Gastrointestinal trials group (AGITG)

Themes

Cancer, Neurosciences and Mental Health

Keywords

Alzheimer's disease, Bowel cancer, Gastroenterology, Proteomics, Biological markers

Approaches

Cellular/Molecular, Translational Research

International links

Germany

(UKE, University of Hamburg) Colorectal cancer proteomics

Germany

(University of Hamburg) International Colorectal Liver Metastasis project

Current research students

Project title	Research student
Characterizing the Oral Microbiome Community Profile in Australian Head and Neck Squamous Cell Carcinoma Patients	Hafiz Saad AHMAD

Publications

By Type

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Book Chapters

Mirzaei, M., Pascovici, D., Wu, J., Chick, J., Wu, Y., Cooke, B., Haynes, P., Molloy, M. (2017). TMT one-stop shop: From reliable sample preparation to computational analysis platform. In Shivakumar Keerthikumar and Suresh Mathivanan (Eds.), Proteome Bioinformatics, (pp. 45-66). New York: Springer. [More Information]
Fung, D., Lo, A., Jankova, L., Clarke, S., Molloy, M., Robertson, G., Wilkins, M. (2011). Classification of Cancer Patients Using Pathway Analysis and Network Clustering. In Gerard Cagney, Andrew Emili (Eds.), Network Biology: Methods and Applications, (pp. 311-336). New York: Humana Press.

Journals

Zhu, H., Wright, B., Logel, D., Needham, P., Yehl, K., Molloy, M., Jaschke, P. (2024). IbpAB small heat shock proteins are not host factors for bacteriophage ϕX174 replication. Virology, 597, 110169. [More Information]
De Silva, M., Tse, B., Diakos, C., Clarke, S., Molloy, M. (2024). Immunogenic cell death in colorectal cancer: a review of mechanisms and clinical utility. Cancer Immunology, Immunotherapy, 73(3), 53. [More Information]
Wong, G., Li, J., Mckay, M., Castaneda, M., Bhimani, N., Diakos, C., Hugh, T., Molloy, M. (2024). Proteogenomic Characterisation of Early Intrahepatic Recurrence After Curative-intent Treatment of Colorectal Liver Metastases. Journal of Proteome Research, 23(10), 4523-4537. [More Information]
Netherton, J., Ogle, R., Robinson, B., Molloy, M., Krisp, C., Velkov, T., Casagranda, F., Dominado, N., Silva Balbin Villaverde, A., Zhang, X., et al (2024). The role of HnrnpF/H as a driver of oligoteratozoospermia. iScience, 27(7). [More Information]
Tse, B., Molloy, M., Bergamin, S., Steffen, P., Hruby, G., Pavlakis, N., Clarke, S., Evans, J., Engel, A., Kneebone, A. (2023). CD11c+ and IRF8+ cell densities in rectal cancer biopsies predict outcomes of neoadjuvant chemoradiotherapy. OncoImmunology, 12(1), 2238506. [More Information]
Welham, Z., Li, J., Engel, A., Molloy, M. (2023). Mucosal Microbiome in Patients with Early Bowel Polyps: Inferences from Short-Read and Long-Read 16S rRNA Sequencing. Cancers, 15(20). [More Information]
O'Rourke, M., Januszewski, A., Sullivan, D., Lengyel, I., Stewart, A., Arya, S., Ma, R., Galande, S., Hardikar, A., Joglekar, M., Keech, A., Jenkins, A., Molloy, M. (2023). Optimised plasma sample preparation and LC-MS analysis to support large-scale proteomic analysis of clinical trial specimens: Application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial. Proteomics - Clinical Applications. [More Information]
Chatterjee, P., Pedrini, S., Doecke, J., Thota, R., Villemagne, V., Doré, V., Singh, A., Wang, P., Rainey-Smith, S., Fowler, C., Molloy, M., et al (2023). Plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross-sectional and longitudinal study in the AIBL cohort. Alzheimer's and Dementia, 19(4), 1117-1134. [More Information]
Molloy, M., Hill, C., Mckay, M., Herbert, B. (2023). Proteome Analysis of Whole Blood Collected by Volumetric Absorptive Microsampling. Methods in Molecular Biology, 2628, 173-179. [More Information]
Mckay, M., Castaneda, M., Catania, S., Charles (nee Slaviero), K., Shanahan, E., Clarke, S., Engel, A., Varelis, P., Molloy, M. (2023). Quantification of short-chain fatty acids in human stool samples by LC-MS/MS following derivatization with aniline analogues. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1217. [More Information]
Li, J., Steffen, P., Tse, B., Seyed Ahadi, M., Gill, A., Engel, A., Molloy, M. (2022). Deep Sequencing of Early T Stage Colorectal Cancers Reveals Disruption of Homologous Recombination Repair in Microsatellite Stable Tumours with High Mutational Burdens. Cancers, 14(12). [More Information]
Rahman, M., Amirkhani, A., Parvin, F., Chowdhury, D., Molloy, M., Deva, A., Vickery, K., Hu, H. (2022). One Step Forward with Dry Surface Biofilm (DSB) of Staphylococcus aureus: TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Shifts between DSB and Hydrated Biofilm. International Journal of Molecular Sciences, 23(20). [More Information]
Wright, B., Molloy, M., Jaschke, P. (2022). Overlapping genes in natural and engineered genomes. Nature Reviews Genetics, 23(3), 154-168. [More Information]
Wong, G., Bhimani, N., Mol, B., Diakos, C., de Reuver, P., Molloy, M., Hugh, T. (2022). Performance of prognostic models incorporating KRAS mutation status to predict survival after resection of colorectal liver metastases. HPB, 24(8), 1316-1325. [More Information]
Chatterjee, P., Vermunt, L., Gordon, B., Pedrini, S., Boonkamp, L., Armstrong, N., Xiong, C., Singh, A., Li, Y., Sohrabi, H., Molloy, M., et al (2022). Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer's and Dementia. [More Information]
Wong, G., Diakos, C., Molloy, M., Hugh, T. (2022). Prognostic Models Incorporating RAS Mutation to Predict Survival in Patients with Colorectal Liver Metastases: A Narrative Review. Cancers, 14(13). [More Information]
Rahman, M., Amirkhani, A., Chowdhury, D., Mempin, M., Molloy, M., Deva, A., Vickery, K., Hu, H. (2022). Proteome of Staphylococcus aureus Biofilm Changes Significantly with Aging. International Journal of Molecular Sciences, 23(12). [More Information]
Molloy, M., Hill, C., O'Rourke, M., Chandra, J., Steffen, P., Mckay, M., Pascovici, D., Herbert, B. (2022). Proteomic Analysis of Whole Blood Using Volumetric Absorptive Microsampling for Precision Medicine Biomarker Studies. Journal of Proteome Research, 21(4), 1196-1203. [More Information]
Wong, G., Diakos, C., Hugh, T., Molloy, M. (2022). Proteomic Profiling and Biomarker Discovery in Colorectal Liver Metastases. International Journal of Molecular Sciences, 23(11), 6091. [More Information]
Wong, G., Mol, B., Bhimani, N., de Reuver, P., Diakos, C., Molloy, M., Hugh, T. (2022). Recurrence patterns predict survival after resection of colorectal liver metastases. ANZ Journal of Surgery, 92(9), 2149-2156. [More Information]
Lyu, N., Pedersen, B., Shklovskaya, E., Rizos, H., Molloy, M., Wang, Y. (2022). SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatment. Exploration, 2(3), 20210176. [More Information]
O'Rourke, M., Sahni, S., Samra, J., Mittal, A., Molloy, M. (2021). Data independent acquisition of plasma biomarkers of response to neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma. Journal of Proteomics, 231, 1-8. [More Information]
Oh, B., Boyle, F., Pavlakis, N., Clarke, S., Guminski, A., Eade, T., Lamoury, G., Carroll, S., Morgia, M., Kneebone, A., Hruby, G., Stevens, M., Molloy, M., Back, M., et al (2021). Emerging Evidence of the Gut Microbiome in Chemotherapy: A Clinical Review. Frontiers in Oncology, 11, 706331. [More Information]
Tse, B., Welham, Z., Engel, A., Molloy, M. (2021). Genomic, microbial and immunological microenvironment of colorectal polyps. Cancers, 13(14), 3382-1-3382-19. [More Information]
Lyu, N., Rajendran, V., Li, J., Engel, A., Molloy, M., Wang, Y. (2021). Highly specific detection of KRAS single nucleotide polymorphism by asymmetric PCR/SERS assay. Analyst, 146(18), 5714-5721. [More Information]
Naidu, V., Shah, B., Kamath, K., Chien, A., Nagy, S., Pokhrel, A., Molloy, M., Hassan, K., Paulsen, I. (2021). Identification of a novel ciprofloxacin tolerance gene, aciT, which contributes to filamentation in acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 65(6), e01400. [More Information]
Holliday, H., Roden, D., Junankar, S., Wu, S., Baker, L., Krisp, C., Chan, C., McFarland, A., Skhinas, J., Cox, T., et al (2021). Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB. iScience, 24(2). [More Information]
Jones, G., Molloy, M. (2021). Metformin, Microbiome and Protection Against Colorectal Cancer. Digestive Diseases and Sciences, 66(5), 1409-1414. [More Information]
Steffen, P., Li, J., Chandra, J., Seyed Ahadi, M., Gill, A., Engel, A., Molloy, M. (2021). Molecular Features of Lymph Node Metastasis in T1/2 Colorectal Cancer from Formalin-Fixed Paraffin-Embedded Archival Specimens. Journal of Proteome Research, 20(2), 1304-1312. [More Information]
Chatterjee, P., Fagan, A., Xiong, C., McKay, M., Bhatnagar, A., Wu, Y., Singh, A., Taddei, K., Martins, I., Gardener, S., Molloy, M., et al (2021). Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations. Journal of Alzheimer's Disease, 79(2), 895-903. [More Information]
Raajendiran, A., Krisp, C., de Souza, D., Ooi, G., Burton, P., Taylor, R., Molloy, M., Watt, M. (2021). Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points. American Journal of Physiology - Endocrinology and Metabolism, 320(6), E1068-E1084. [More Information]
Wright, B., Logel, D., Mirzai, M., Pascovici, D., Molloy, M., Jaschke, P. (2021). Proteomic and transcriptomic analysis of microviridae wX174 infection reveals broad upregulation of host escherichia coli membrane damage and heat shock responses. msystems, 6(3), e00046. [More Information]
Santos, J., Dolai, S., O'Rourke, M., Liu, F., Padula, M., Molloy, M., Milthorpe, B. (2021). Quantitative proteomic profiling of small molecule treated mesenchymal stem cells using chemical probes. International Journal of Molecular Sciences, 22(1), 1-20. [More Information]
Oh, B., Boyle, F., Pavlakis, N., Clarke, S., Eade, T., Hruby, G., Lamoury, G., Carroll, S., Morgia, M., Kneebone, A., Stevens, M., Molloy, M., Kong, B., Back, M., et al (2021). The gut microbiome and cancer immunotherapy: Can we use the gut microbiome as a predictive biomarker for clinical response in cancer immunotherapy? Cancers, 13(19), 4824. [More Information]
Oh, B., Eade, T., Lamoury, G., Carroll, S., Morgia, M., Kneebone, A., Hruby, G., Stevens, M., Boyle, F., Clarke, S., Molloy, M., Back, M., et al (2021). The gut microbiome and gastrointestinal toxicities in pelvic radiation therapy: A clinical review. Cancers, 13(10), 2353. [More Information]
Gamage, H., Chong, R., Bucio-Noble, D., Kautto, L., Hardikar, A., Ball, M., Molloy, M., Packer, N., Paulsen, I. (2020). Changes in dietary fiber intake in mice reveal associations between colonic mucin O-glycosylation and specific gut bacteria. Gut Microbes, 12(1), 1802209. [More Information]
Voss, H., Wurlitzer, M., Smit, D., Ewald, F., Alawi, M., Spohn, M., Indenbirken, D., Omidi, M., David, K., Juhl, H., Molloy, M., et al (2020). Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer. Clinical and Experimental Metastasis, 37(6), 649-656. [More Information]
Piggin, C., Roden, D., Law, A., Molloy, M., Krisp, C., Swarbrick, A., Naylor, M., Kalyuga, M., Kaplan, W., Oakes, S., et al (2020). ELF5 modulates the estrogen receptor cistrome in breast cancer. PLoS Genetics, 16(1), 1-24. [More Information]
Bhatnagar, A., McKay, M., Arasaratnam, M., Crumbaker, M., Gurney, H., Molloy, M. (2020). Evaluating bioanalytical capabilities of paper spray ionization for abiraterone drug quantification in patient plasma. Journal of Mass Spectrometry, 55(10), e4584. [More Information]
Wright, B., Ruan, J., Molloy, M., Jaschke, P. (2020). Genome modularization reveals overlapped gene topology is necessary for efficient viral reproduction. ACS Synthetic Biology, 9(11), 3079-3090. [More Information]
Sahni, S., Nahm, C., Krisp, C., Molloy, M., Mehta, S., Maloney, S., Itchins, M., Pavlakis, N., Clarke, S., Chan, D., Gill, A., Howell, V., Samra, J., Mittal, A. (2020). Identification of Novel Biomarkers in Pancreatic Tumor Tissue to Predict Response to Neoadjuvant Chemotherapy. Frontiers in Oncology, 10, 1-10. [More Information]
Lyu, N., Rajendran, V., Diefenbach, R., Charles (nee Slaviero), K., Clarke, S., Engel, A., Rizos, H., Molloy, M., Wang, Y. (2020). Multiplex detection of ctdna mutations in plasma of colorectal cancer patients by pcr/sers assay. Nanotheranostics, 4(4), 224-232. [More Information]
Steffen, P., Wu, J., Hariharan, S., Voss, H., Raghunath, V., Molloy, M., Schlüter, H. (2020). Omixlitminer: A bioinformatics tool for prioritizing biological leads from ‘omics data using literature retrieval and data mining. International Journal of Molecular Sciences, 21(4), 1-11. [More Information]
Thejer, B., Adhikary, P., Kaur, A., Teakel, S., Van Oosterum, A., Seth, I., Pajic, M., Hannan, K., Pavy, M., Poh, P., Patrick, E., New, E., et al (2020). PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth. BMC Molecular and Cell Biology, 21(1), 1-24. [More Information]
Sahni, S., Krisp, C., Molloy, M., Nahm, C., Maloney, S., Gillson, J., Gill, A., Samra, J., Mittal, A. (2020). PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. Biochimica et Biophysica Acta - General Subjects, 1864 (11), 1-6. [More Information]
Clarke, S., Burge, M., Feeney, K., Gibbs, P., Jones, K., Marx, G., Molloy, M., Price, T., Reece, W., Segelov, E., et al (2020). The prognostic role of inflammatory markers in patients with metastatic colorectal cancer treated with bevacizumab: A translational study [ASCENT]. PloS One, 15(3), e0229900. [More Information]
Bhatnagar, A., McKay, M., Thaysen-Andersen, M., Arasaratnam, M., Crumbaker, M., Gurney, H., Molloy, M. (2019). Bioanalytical evaluation of dried plasma spots for monitoring of abiraterone and Delta(4)-abiraterone from cancer patients. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1126-1127, 1-9. [More Information]
Bucio-Noble, D., Semaan, C., Molloy, M. (2019). Examining cellular responses to kinase drug inhibition through phosphoproteome mapping of substrates. Methods in Molecular Biology, 1888, 141-152. [More Information]
Arasaratnam, M., Crumbaker, M., Bhatnagar, A., McKay, M., Molloy, M., Gurney, H. (2019). Inter- and intra-patient variability in pharmacokinetics of abiraterone acetate in metastatic prostate cancer. Cancer Chemotherapy and Pharmacology, 84(1), 139-146. [More Information]
Noor, Z., Wu, J., Pascovici, D., Mohamedali, A., Molloy, M., Baker, M., Ranganathan, S. (2019). ISwathX: An interactive web-based application for extension of DIA peptide reference libraries. Bioinformatics, 35(3), 538-539. [More Information]
Wright, B., Kamath, K., Krisp, C., Molloy, M. (2019). Proteome profiling of Pseudomonas aeruginosa PAO1 identifies novel responders to copper stress. BMC Microbiology, 19(1), 69. [More Information]
Semaan, C., Henderson, B., Molloy, M. (2019). Proteomic screen with the proto-oncogene beta-catenin identifies interaction with Golgi coatomer complex I. Biochemistry and Biophysics Reports, 19, 1-6. [More Information]
McRobb, L., McKay, M., Gauden, A., Lee, V., Subramanian, S., Thomas, S., Wiedmann, M., Moutrie, V., Grace, M., Zhao, Z., Molloy, M., et al (2019). Radiation-stimulated translocation of CD166 and CRYAB to the endothelial surface provides potential vascular targets on irradiated brain arteriovenous malformations. International Journal of Molecular Sciences, 20(23), 1-13. [More Information]
Martinez-Aguilar, J., Molloy, M. (2019). Targeted mass spectrometry of S100 proteins. Methods in Molecular Biology, 1929, 663-678. [More Information]
Bezawork-Geleta, A., Wen, H., Dong, L., Yan, B., Vider, J., Boukalova, S., Krobova, L., Vanova, K., Zobalova, R., Sobol, M., et al (2018). Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints. Nature Communications, 9(1). [More Information]
Lin, C., Krisp, C., Packer, N., Molloy, M. (2018). Development of a data independent acquisition mass spectrometry workflow to enable glycopeptide analysis without predefined glycan compositional knowledge. Journal of Proteomics, 172, 68-75. [More Information]
Gamage, H., Tetu, S., Chong, R., Bucio-Noble, D., Rosewarne, C., Kautto, L., Ball, M., Molloy, M., Packer, N., Paulsen, I. (2018). Fiber supplements derived from sugarcane stem, wheat dextrin and psyllium husk have different in vitro effects on the human gut microbiota. Frontiers in Microbiology, 9(Issue JUL), 1618. [More Information]
Steffen, P., Krisp, C., Yi, W., Yang, P., Molloy, M., Schluter, H. (2018). Multi-laboratory analysis of the variability of shipped samples for proteomics following non-cooled international transport. Analytical Biochemistry, 548, 60-65. [More Information]
Lee, A., Rayner, S., Gwee, S., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., et al (2018). Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Cellular and Molecular Life Sciences, 75(2), 335-354. [More Information]
Semaan, C., Neilson, K., Brown, B., Molloy, M. (2018). Pharmacological inhibition of casein kinase 2 enhances the effectiveness of PI3K inhibition in colon cancer cells. Anticancer Research, 38(11), 6195-6200. [More Information]
Bucio-Noble, D., Kautto, L., Krisp, C., Ball, M., Molloy, M. (2018). Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model. Journal of Proteomics, 177, 1-10. [More Information]
Molloy, M., Engel, A. (2018). Precision medicine beyond medical oncology: using molecular analysis to guide treatments of colorectal neoplasia. Expert Review of Gastroenterology and Hepatology, 12(12), 1179-1181. [More Information]
Krisp, C., Parker, R., Pascovici, D., Hayward, N., Wilmott, J., Thompson, J., Mann, G., Long, G., Scolyer, R., Molloy, M. (2018). Proteomic phenotyping of metastatic melanoma reveals putative signatures of MEK inhibitor response and prognosis. British Journal of Cancer, 119(6), 713-723. [More Information]
Scott, C., de Souza, F., Aristizabal, V., Hethrington, L., Krisp, C., Molloy, M., Baker, M., Dell'Aqua, J. (2018). Proteomic profile of sex-sorted bull sperm evaluated by SWATH-MS analysis. Animal Reproduction Science, 198, 121-128. [More Information]
Simonian, M., Shirasaki, D., Lee, V., Bervini, D., Grace, M., Loo, R., Loo, J., Molloy, M., Stoodley, M. (2018). Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy. Clinical Proteomics, 15(1), 43. [More Information]
Bhatnagar, A., McKay, M., Crumbaker, M., Ahire, K., Karuso, P., Gurney, H., Molloy, M. (2018). Quantitation of the anticancer drug abiraterone and its metabolite (delta)(4)-abiraterone in human plasma using high-resolution mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 154, 66-74. [More Information]
Mirzaei, M., Gupta, V., Chick, J., Greco, T., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., You, Y., Graham, S., et al (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Scientific Reports, 7(1), 1-16. [More Information]
Lee, A., Rayner, S., De Luca, A., Gwee, S., Morsch, M., Sundaramoorthy, V., Shahheydari, H., Ragagnin, A., Shi, B., Yang, S., et al (2017). Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex. Open Biology, 7(10), 1-11. [More Information]
Hogan, A., Don, E., Rayner, S., Lee, A., Laird, A., Watchon, M., Winnick, C., Tarr, I., Morsch, M., Fifita, J., Nicholson, G., et al (2017). Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human Molecular Genetics, 26(14), 2616-2626. [More Information]
Simonian, M., Ogorzalek Loo, R., Rannulu, N., Loo, J., Molloy, M., Stoodley, M. (2017). Identification of protein targets in cerebral endothelial cells for brain arteriovenous malformation (AVMs) molecular therapies. Clinical Proteomics, 14(1), 1-12. [More Information]
Wu, J., Pascovici, D., Ignjatovic, V., Song, X., Krisp, C., Molloy, M. (2017). Improving Protein Detection Confidence Using SWATH-Mass Spectrometry with Large Peptide Reference Libraries. Proteomics, 17(19), 1-5. [More Information]
McRobb, L., McKay, M., Gamble, J., Grace, M., Moutrie, V., Santos, E., Lee, V., Zhao, Z., Molloy, M., Stoodley, M. (2017). Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. Aging, 9(4), 1248-1268. [More Information]
Collins, B., Hunter, C., Liu, Y., Schilling, B., Rosenberger, G., Bader, S., Chan, D., Gibson, B., Gingras, A., Held, J., et al (2017). Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry. Nature Communications, 8(1), 1-12. [More Information]
Agbaje, O., Thomas, D., Mclnerney, B., Molloy, M., Jacob, D. (2017). Organic macromolecules in shells of Arctica islandica: comparison with nacroprismatic bivalve shells. Marine Biology, 164(11), 1-13. [More Information]
Tan, S., Lee, A., Pascovici, D., Care, N., Birzniece, V., Ho, K., Molloy, M., Khan, A. (2017). Plasma biomarker proteins for detection of human growth hormone administration in athletes. Scientific Reports, 7(1), 1-12. [More Information]
Kamath, K., Krisp, C., Chick, J., Pascovici, D., Gygi, S., Molloy, M. (2017). Pseudomonas aeruginosa Proteome under Hypoxic Stress Conditions Mimicking the Cystic Fibrosis Lung. Journal of Proteome Research, 16(10), 3917-3928. [More Information]
Bjelosevic, S., Pascovici, D., Ping, H., Karlaftis, V., Zaw, T., Song, X., Molloy, M., Monagle, P., Ignjatovic, V. (2017). Quantitative age-specific variability of plasma proteins in healthy neonates, children and adults. Molecular and Cellular Proteomics, 16(5), 924-935. [More Information]
McRobb, L., Lee, V., Simonian, M., Zhao, Z., Thomas, S., Wiedmann, M., Amal Raj, J., Grace, M., Moutrie, V., McKay, M., et al (2017). Radiosurgery Alters the Endothelial Surface Proteome: Externalized Intracellular Molecules as Potential Vascular Targets in Irradiated Brain Arteriovenous Malformations. Radiation Research, 187(1), 66-78. [More Information]
Krisp, C., Molloy, M. (2017). SWATH mass spectrometry for proteomics of non-depleted plasma. Methods in Molecular Biology, 1619, 373-383. [More Information]
Johnson, A., Zaman, M., Veljanoski, F., Phrakaysone, A., Li, S., O'Doherty, P., Petersingham, G., Perrone, G., Molloy, M., Wu, M. (2017). Unravelling the role of protein kinase CK2 in metal toxicity using gene deletion mutants. Metallomics, 9(3), 301-308. [More Information]
Kao, S., Kirschner, M., Cooper, W., Tran, T., Burgers, S., Wright, C., Korse, T., van den Broek, D., Edelman, J., Vallely, M., McCaughan, B., Pavlakis, N., Clarke, S., van Zandwijk, N., Reid, G., et al (2016). A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma. British Journal of Cancer, 114(5), 524-531. [More Information]
Song, X., Amirkhani, A., Wu, J., Pascovici, D., Zaw, T., Xavier, D., Clarke, S., Molloy, M. (2016). Analytical performance of nano-LC-SRM using nondepleted human plasma over an 18-month period. Proteomics, 16(15-16), 2118-2127. [More Information]
Williams, K., Topp, S., Yang, S., Smith, B., Fifita, J., Warraich, S., Zhang, K., Farrawell, N., Vance, C., Dobson-Stone, C., Cole, N., Nicholson, G., et al (2016). CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nature Communications, 7, 1-8. [More Information]
Al-Eisawi, Z., Beale, P., Chan, C., Yu, J., Proschogo, N., Molloy, M., Huq, F. (2016). Changes in the in vitro activity of platinum drugs when administered in two aliquots. BMC Cancer, 16(1), 1-25. [More Information]
Morris, K., O'Meally, D., Zaw, T., Song, X., Gillett, A., Molloy, M., Polkinghorne, A., Belov, K. (2016). Characterisation of the immune compounds in koala milk using a combined transcriptomic and proteomic approach. Scientific Reports, 6, 1-14. [More Information]
Jamieson, C., Mills, K., Lui, C., Semaan, C., Molloy, M., Sharma, M., Forwood, J., Henderson, B. (2016). Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells. Experimental Cell Research, 341(2), 196-206. [More Information]
Hayes, S., Haefliger, S., Harris, B., Pavlakis, N., Clarke, S., Molloy, M., Howell, V. (2016). Exhaled breath condensate for lung cancer protein analysis: a review of methods and biomarkers. Journal of Breath Research, 10(3), 1-26. [More Information]
Succar, P., Medynskyj, M., Breen, E., Batterham, T., Molloy, M., Herbert, B. (2016). Priming Adipose-Derived Mesenchymal Stem Cells with Hyaluronan Alters Growth Kinetics and Increases Attachment to Articular Cartilage. Stem Cells International, 2016, 1-13. [More Information]
Martinez-Aguilar, J., Clifton-Bligh, R., Molloy, M. (2016). Proteomics of thyroid tumours provides new insights into their molecular composition and changes associated with malignancy. Scientific Reports, 6, 1-12. [More Information]
Kamath, K., Pascovici, D., Penesyan, A., Goel, A., Venkatakrishnan, V., Paulsen, I., Packer, N., Molloy, M. (2016). Pseudomonas aeruginosa Cell Membrane Protein Expression from Phenotypically Diverse Cystic Fibrosis Isolates Demonstrates Host-Specific Adaptations. Journal of Proteome Research, 15(7), 2152-2163. [More Information]
Wu, J., Song, X., Pascovici, D., Zaw, T., Care, N., Krisp, C., Molloy, M. (2016). SWATH mass spectrometry performance using extended peptide MS/MS assay libraries. Molecular and Cellular Proteomics, 15(7), 2501-2514. [More Information]
Martinez-Aguilar, J., Clifton-Bligh, R., Molloy, M. (2015). A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours. BMC Cancer, 15(1), 1-14. [More Information]
Pascovici, D., Song, X., Solomon, P., Winterberg, B., Mirzaei, M., Goodchild, A., Stanley, W., Liu, J., Molloy, M. (2015). Combining Protein Ratio p-Values as a Pragmatic Approach to the Analysis of Multirun iTRAQ Experiments. Journal of Proteome Research, 14(2), 738-746. [More Information]
Mahon, K., Lin, H., Castillo, L., Lee, B., Lee-Ng, K., Chatfield, M., Chiam, K., Breit, S., Brown, D., Molloy, M., Marx, G., Pavlakis, N., Boyer, M., Stockler, M., Horvath, L., et al (2015). Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer. British Journal of Cancer, 112(8), 1340-1348. [More Information]
Meex, R., Hoy, A., Morris, A., Brown, R., Lo, J., Burke, M., Goode, R., Kingwell, B., Kraakman, M., Febbraio, M., et al (2015). Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism. Cell Metabolism, 22(6), 1078-1089. [More Information]
Penesyan, A., Kumar, S., Kamath, K., Shathili, A., Venkatakrishnan, V., Krisp, C., Packer, N., Molloy, M., Paulsen, I. (2015). Genetically and phenotypically distinct pseudomonas aeruginosa cystic fibrosis isolates share a core proteomic signature. PloS One, 10(10), e0138527. [More Information]
Percy, A., Tamura-Wells, J., Albar, J., Aloria, K., Amirkhani, A., Araujo, G., Arizmendi, J., Blanco, F., Canals, F., Cho, J., et al (2015). Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment. EuPA Open Proteomics.
Lin, C., Chik, J., Packer, N., Molloy, M. (2015). Multidimensional fractionation is a requirement for quantitation of golgi-resident glycosylation enzymes from cultured human cells. Journal of Proteome Research, 14(2), 747-755. [More Information]
Krisp, C., Yang, H., van Soest, R., Molloy, M. (2015). Online peptide fractionation using a multiphasic microfluidic liquid chromatography chip improves reproducibility and detection limits for quantitation in discovery and targeted proteomics. Molecular and Cellular Proteomics, 14(6), 1708-1719. [More Information]
Parker, R., Vella, L., Xavier, D., Amirkhani, A., Parker, J., Cebon, J., Molloy, M. (2015). Phosphoproteomic analysis of cell-based resistance to BRAF inhibitor therapy in melanoma. Frontiers in Oncology, 5(MAY), 95. [More Information]
Kamath, K., Kumar, S., Kaur, J., Venkatakrishnan, V., Paulsen, I., Nevalainen, H., Molloy, M. (2015). Proteomics of hosts and pathogens in cystic fibrosis. Proteomics - Clinical Applications, 9, 134-146. [More Information]
Jankova, L., Dent, O., Molloy, M., Chan, C., Chapuis, P., Howell, V., Clarke, S. (2015). Reporting in studies of protein biomarkers of prognosis in colorectal cancer in relation to the REMARK guidelines. Proteomics - Clinical Applications, 9(11-12), 1078-1086. [More Information]
Schilter, H., Cantemir-Stone, C., Leksa, V., Ohradanova-Repic, A., Findlay, A., Deodhar, M., Stockinger, H., Song, X., Molloy, M., Marsh, C., et al (2015). The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-?1 pathway in human lung fibroblasts. Immunology Letters, 165(2), 90-101. [More Information]
Chik, J., Zhou, J., Moh, E., Christopherson, R., Clarke, S., Molloy, M., Packer, N. (2014). Comprehensive glycomics comparison between colon cancer cell cultures and tumours: Implications for biomarker studies. Journal of Proteomics, 108, 146-162. [More Information]
Alexander, K., Ly, L., McKay, M., Mallawaaratchy, D., Mactier, S., Crossett, B., Molloy, M., Buckland, M., McDonald, K., Christopherson, R. (2014). Comprehensive proteomic profiling of bevacizumab-resistant glioblastoma multiforme. Neuro-Oncology, 16(Suppl 2), ii98-ii98.
Hayes, S., Hudson, A., Clarke, S., Molloy, M., Howell, V. (2014). From mice to men: GEMMs as trial patients for new NSCLC therapies. Seminars in Cell & Developmental Biology, 27, 118-127. [More Information]
Parker, R., Clifton-Bligh, R., Molloy, M. (2014). Phosphoproteomics of MAPK inhibition in BRAF mutated cells and a role for the lethal synergism of dual BRAF and CK2 inhibition. Molecular Cancer Therapeutics, 13(7), 1894-1906. [More Information]
Voros, A., Simm, R., Slamti, L., McKay, M., Hegna, I., Nielsen-LeRoux, C., Hassan, K., Paulsen, I., Molloy, M., et al (2014). SecDF as part of the sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins. PloS One, 9(8). [More Information]
Hart-Smith, G., Chia, S., Low, J., McKay, M., Molloy, M., Wilkins, M. (2014). Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-histone Protein Lysine Methyltransferase Activity. Journal of Proteome Research, 13(3), 1744-1756. [More Information]
Winterberg, B., Du Fall, L., Song, X., Pascovici, D., Care, N., Molloy, M., Ohms, S., Solomon, P. (2014). The necrotrophic effector protein SnTox3 re-programs metabolism and elicits a strong defence response in susceptible wheat leaves. BMC Plant Biology, 14(1), 215. [More Information]
Pascovici, D., Gardiner, D., Song, X., Breen, E., Solomon, P., Keighley, T., Molloy, M. (2013). Coverage and consistency: Bioinformatics aspects of the analysis of multirun iTRAQ experiments with wheat leaves. Journal of Proteome Research, 12(11), 4870-4881. [More Information]
Martinez-Aguilar, J., Molloy, M. (2013). Label-free selected reaction monitoring enables multiplexed quantitation of S100 protein isoforms in cancer cells. Journal of Proteome Research, 12(8), 3679-3688. [More Information]
Krisp, C., Jacobsen, F., McKay, M., Molloy, M., Steinstraesser, L., Wolters, D. (2013). Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients. Proteomics, 13(17), 2670-2681. [More Information]
Martinez-Aguilar, J., Chik, J., Nicholson, J., Semaan, C., McKay, M., Molloy, M. (2013). Quantitative mass spectrometry for colorectal cancer proteomics. Proteomics - Clinical Applications, 7(1-Feb), 42-54. [More Information]
Lee, A., Molloy, M., Baker, M., Kapur, A. (2013). Tandem ion exchange fractionation of chicken egg white reveals the presence of proliferative bioactivity. Journal of Agricultural and Food Chemistry, 61(17), 4079-4088. [More Information]
Molloy, M. (2013). Two-stepping to increase peptide spectra matches in large databases. Proteomics, 13(8), 1229-30. [More Information]
Nicholson, J., Neelagandan, K., Huart, A., Ball, K., Molloy, M., Hupp, T. (2012). An iTRAQ Proteomics Screen Reveals the Effects of the MDM2 Binding Ligand Nutlin-3 on Cellular Proteostasis. Journal of Proteome Research, 11(11), 5464-5478. [More Information]
Jankova, L., Robertson, G., Chan, C., Tan, K., Kohonen-Corish, M., Fung, C., Clarke, C., Lin, B., Molloy, M., Chapuis, P., Bokey, E., Dent, O., Clarke, S. (2012). Glutathione S-transferase Pi expression predicts response to adjuvant chemotherapy for stage C colon cancer: a matched historical control study. BMC Cancer, 12, 1-9. [More Information]
Krisp, C., McKay, M., Wolters, D., Molloy, M. (2012). Multidimensional protein identification technology-selected reaction monitoring improving detection and quantification for protein biomarker studies. Analytical Chemistry, 84(3), 1592-1600. [More Information]
Sigglekow, N., Pangon, L., Brummer, T., Molloy, M., Hawkins, N., Ward, R., Musgrove, E., Kohonen-Corish, M. (2012). Mutated in colorectal cancer protein modulates the NF?B pathway. Anticancer Research, 32(1), 73-79.
Kho, P., Jankova, L., Fung, C., Chan, C., Clarke, C., Lin, B., Robertson, G., Molloy, M., Chapuis, P., Bokey, E., Dent, O., Clarke, S. (2012). Overexpression of protein S100A4 is independently associated with overall survival in stage C colonic cancer but only in cytoplasm at the advancing tumour front. International Journal of Colorectal Disease, 27(11), 1409-1417. [More Information]
Randall, S., McKay, M., Pascovici, D., Mahon, K., Horvath, L., Clarke, S., Molloy, M. (2012). Remarkable temporal stability of high-abundance human plasma proteins assessed by targeted mass spectrometry. Proteomics - Clinical Applications, 6(11-12), 626-634. [More Information]
Sharma, M., Jamieson, C., Johnson, M., Molloy, M., Henderson, B. (2012). Specific Armadillo Repeat Sequences Facilitate beta-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358. Journal of Biological Chemistry, 287(2), 819-831. [More Information]
Krisp, C., Randall, S., McKay, M., Molloy, M. (2012). Towards clinical applications of selected reaction monitoring for plasma protein biomarker studies. Proteomics - Clinical Applications, 6(1-2), 42-59. [More Information]
Sherman, J., Molloy, M., Burlingame, A. (2012). Why complexity and entropy matter: Information, posttranslational modifications, and assay fidelity. Proteomics, 12(8), 1147-1150. [More Information]
Tan, K., Jankova, L., Chan, C., Fung, C., Clarke, C., Lin, B., Robertson, G., Molloy, M., Chapuis, P., Bokey, E., Clarke, S., et al (2011). Clinicopathological correlates and prognostic significance of glutathione S-transferase Pi expression in 468 patients after potentially curative resection of node-positive colonic cancer. Histopathology, 59(6), 1057-1070. [More Information]
Yang, J., MacDougall, M., McDowell, M., Xi, L., Wei, R., Zavadoski, W., Molloy, M., Baker, J., Kuhn, M., Cabrera, O., et al (2011). Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC Genomics, 12, 1-14. [More Information]
Jankova, L., Chan, C., Fung, C., Song, X., Kwun, S., Cowley, M., Kaplan, W., Dent, O., Bokey, E., Chapuis, P., Robertson, G., Clarke, S., et al (2011). Proteomic comparison of colorectal tumours and non-neoplastic mucosa from paired patient samples using iTRAQ mass spectrometry. Molecular BioSystems, 7(11), 2997-3005. [More Information]
Dolai, S., Xu, Q., Liu, F., Molloy, M. (2011). Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells. Proteomics, 11(13), 2683-2692. [More Information]
Ali, N., Molloy, M. (2011). Quantitative phosphoproteomics of transforming growth factor-Î² signaling in colon cancer cells. Proteomics, 11(16), 3390-3401. [More Information]
Fung, C., Chan, C., Jankova, L., Dent, O., Robertson, G., Molloy, M., Bokey, E., Chapuis, P., Lin, B., Clarke, S. (2010). Clinicopathological correlates and prognostic significance of maspin expression in 450 patients after potentially curative resection of node-positive colonic cancer. Histopathology, 56(3), 319-330. [More Information]
Lam, F., Jankova, L., Dent, O., Molloy, M., Kwun, S., Clarke, C., Chapuis, P., Robertson, G., Beale, P., Clarke, S., Bokey, E., Chan, C. (2010). Identification of distinctive protein expression patterns in colorectal adenoma. Proteomics - Clinical Applications, 4(1), 60-70. [More Information]
Zhao, L., Lee, B., Brown, D., Molloy, M., Marx, G., Pavlakis, N., Boyer, M., Stockler, M., Kaplan, W., Breit, S., et al (2009). Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling. Cancer Research, 69(19), 7696-7703. [More Information]
McKay, M., Sherman, J., Laver, M., Baker, M., Clarke, S., Molloy, M. (2007). The development of multiple reaction monitoring assays for liver-derived plasma proteins. Proteomics - Clinical Applications, 1(12), 1570-1581. [More Information]

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Conferences

Pham, B., Molloy, M., Gamage, H., Emerson, M., Pham, T., Paulsen, I., Hawkett, B., Engel, A. (2021). Development of nanoparticles as biosensors for diagnosis of mucosa changes in situ during colonoscopy. Sydney Cancer Conference 2021, Australia: John Wiley & Sons. [More Information]
Wu, J., Breen, E., Song, X., Cooke, B., Molloy, M. (2013). A protein annotation framework empowered with semantic reasoning. 12th International Semantic Web Conference, ISWC 2013, Australia: CEUR-WS.

By Year

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2024

Zhu, H., Wright, B., Logel, D., Needham, P., Yehl, K., Molloy, M., Jaschke, P. (2024). IbpAB small heat shock proteins are not host factors for bacteriophage ϕX174 replication. Virology, 597, 110169. [More Information]
De Silva, M., Tse, B., Diakos, C., Clarke, S., Molloy, M. (2024). Immunogenic cell death in colorectal cancer: a review of mechanisms and clinical utility. Cancer Immunology, Immunotherapy, 73(3), 53. [More Information]
Wong, G., Li, J., Mckay, M., Castaneda, M., Bhimani, N., Diakos, C., Hugh, T., Molloy, M. (2024). Proteogenomic Characterisation of Early Intrahepatic Recurrence After Curative-intent Treatment of Colorectal Liver Metastases. Journal of Proteome Research, 23(10), 4523-4537. [More Information]
Netherton, J., Ogle, R., Robinson, B., Molloy, M., Krisp, C., Velkov, T., Casagranda, F., Dominado, N., Silva Balbin Villaverde, A., Zhang, X., et al (2024). The role of HnrnpF/H as a driver of oligoteratozoospermia. iScience, 27(7). [More Information]

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2023

Tse, B., Molloy, M., Bergamin, S., Steffen, P., Hruby, G., Pavlakis, N., Clarke, S., Evans, J., Engel, A., Kneebone, A. (2023). CD11c+ and IRF8+ cell densities in rectal cancer biopsies predict outcomes of neoadjuvant chemoradiotherapy. OncoImmunology, 12(1), 2238506. [More Information]
Welham, Z., Li, J., Engel, A., Molloy, M. (2023). Mucosal Microbiome in Patients with Early Bowel Polyps: Inferences from Short-Read and Long-Read 16S rRNA Sequencing. Cancers, 15(20). [More Information]
O'Rourke, M., Januszewski, A., Sullivan, D., Lengyel, I., Stewart, A., Arya, S., Ma, R., Galande, S., Hardikar, A., Joglekar, M., Keech, A., Jenkins, A., Molloy, M. (2023). Optimised plasma sample preparation and LC-MS analysis to support large-scale proteomic analysis of clinical trial specimens: Application to the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial. Proteomics - Clinical Applications. [More Information]
Chatterjee, P., Pedrini, S., Doecke, J., Thota, R., Villemagne, V., Doré, V., Singh, A., Wang, P., Rainey-Smith, S., Fowler, C., Molloy, M., et al (2023). Plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross-sectional and longitudinal study in the AIBL cohort. Alzheimer's and Dementia, 19(4), 1117-1134. [More Information]
Molloy, M., Hill, C., Mckay, M., Herbert, B. (2023). Proteome Analysis of Whole Blood Collected by Volumetric Absorptive Microsampling. Methods in Molecular Biology, 2628, 173-179. [More Information]
Mckay, M., Castaneda, M., Catania, S., Charles (nee Slaviero), K., Shanahan, E., Clarke, S., Engel, A., Varelis, P., Molloy, M. (2023). Quantification of short-chain fatty acids in human stool samples by LC-MS/MS following derivatization with aniline analogues. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1217. [More Information]

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2022

Li, J., Steffen, P., Tse, B., Seyed Ahadi, M., Gill, A., Engel, A., Molloy, M. (2022). Deep Sequencing of Early T Stage Colorectal Cancers Reveals Disruption of Homologous Recombination Repair in Microsatellite Stable Tumours with High Mutational Burdens. Cancers, 14(12). [More Information]
Rahman, M., Amirkhani, A., Parvin, F., Chowdhury, D., Molloy, M., Deva, A., Vickery, K., Hu, H. (2022). One Step Forward with Dry Surface Biofilm (DSB) of Staphylococcus aureus: TMT-Based Quantitative Proteomic Analysis Reveals Proteomic Shifts between DSB and Hydrated Biofilm. International Journal of Molecular Sciences, 23(20). [More Information]
Wright, B., Molloy, M., Jaschke, P. (2022). Overlapping genes in natural and engineered genomes. Nature Reviews Genetics, 23(3), 154-168. [More Information]
Wong, G., Bhimani, N., Mol, B., Diakos, C., de Reuver, P., Molloy, M., Hugh, T. (2022). Performance of prognostic models incorporating KRAS mutation status to predict survival after resection of colorectal liver metastases. HPB, 24(8), 1316-1325. [More Information]
Chatterjee, P., Vermunt, L., Gordon, B., Pedrini, S., Boonkamp, L., Armstrong, N., Xiong, C., Singh, A., Li, Y., Sohrabi, H., Molloy, M., et al (2022). Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer's and Dementia. [More Information]
Wong, G., Diakos, C., Molloy, M., Hugh, T. (2022). Prognostic Models Incorporating RAS Mutation to Predict Survival in Patients with Colorectal Liver Metastases: A Narrative Review. Cancers, 14(13). [More Information]
Rahman, M., Amirkhani, A., Chowdhury, D., Mempin, M., Molloy, M., Deva, A., Vickery, K., Hu, H. (2022). Proteome of Staphylococcus aureus Biofilm Changes Significantly with Aging. International Journal of Molecular Sciences, 23(12). [More Information]
Molloy, M., Hill, C., O'Rourke, M., Chandra, J., Steffen, P., Mckay, M., Pascovici, D., Herbert, B. (2022). Proteomic Analysis of Whole Blood Using Volumetric Absorptive Microsampling for Precision Medicine Biomarker Studies. Journal of Proteome Research, 21(4), 1196-1203. [More Information]
Wong, G., Diakos, C., Hugh, T., Molloy, M. (2022). Proteomic Profiling and Biomarker Discovery in Colorectal Liver Metastases. International Journal of Molecular Sciences, 23(11), 6091. [More Information]
Wong, G., Mol, B., Bhimani, N., de Reuver, P., Diakos, C., Molloy, M., Hugh, T. (2022). Recurrence patterns predict survival after resection of colorectal liver metastases. ANZ Journal of Surgery, 92(9), 2149-2156. [More Information]
Lyu, N., Pedersen, B., Shklovskaya, E., Rizos, H., Molloy, M., Wang, Y. (2022). SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatment. Exploration, 2(3), 20210176. [More Information]

show 8 more

2021

O'Rourke, M., Sahni, S., Samra, J., Mittal, A., Molloy, M. (2021). Data independent acquisition of plasma biomarkers of response to neoadjuvant chemotherapy in pancreatic ductal adenocarcinoma. Journal of Proteomics, 231, 1-8. [More Information]
Pham, B., Molloy, M., Gamage, H., Emerson, M., Pham, T., Paulsen, I., Hawkett, B., Engel, A. (2021). Development of nanoparticles as biosensors for diagnosis of mucosa changes in situ during colonoscopy. Sydney Cancer Conference 2021, Australia: John Wiley & Sons. [More Information]
Oh, B., Boyle, F., Pavlakis, N., Clarke, S., Guminski, A., Eade, T., Lamoury, G., Carroll, S., Morgia, M., Kneebone, A., Hruby, G., Stevens, M., Molloy, M., Back, M., et al (2021). Emerging Evidence of the Gut Microbiome in Chemotherapy: A Clinical Review. Frontiers in Oncology, 11, 706331. [More Information]
Tse, B., Welham, Z., Engel, A., Molloy, M. (2021). Genomic, microbial and immunological microenvironment of colorectal polyps. Cancers, 13(14), 3382-1-3382-19. [More Information]
Lyu, N., Rajendran, V., Li, J., Engel, A., Molloy, M., Wang, Y. (2021). Highly specific detection of KRAS single nucleotide polymorphism by asymmetric PCR/SERS assay. Analyst, 146(18), 5714-5721. [More Information]
Naidu, V., Shah, B., Kamath, K., Chien, A., Nagy, S., Pokhrel, A., Molloy, M., Hassan, K., Paulsen, I. (2021). Identification of a novel ciprofloxacin tolerance gene, aciT, which contributes to filamentation in acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 65(6), e01400. [More Information]
Holliday, H., Roden, D., Junankar, S., Wu, S., Baker, L., Krisp, C., Chan, C., McFarland, A., Skhinas, J., Cox, T., et al (2021). Inhibitor of Differentiation 4 (ID4) represses mammary myoepithelial differentiation via inhibition of HEB. iScience, 24(2). [More Information]
Jones, G., Molloy, M. (2021). Metformin, Microbiome and Protection Against Colorectal Cancer. Digestive Diseases and Sciences, 66(5), 1409-1414. [More Information]
Steffen, P., Li, J., Chandra, J., Seyed Ahadi, M., Gill, A., Engel, A., Molloy, M. (2021). Molecular Features of Lymph Node Metastasis in T1/2 Colorectal Cancer from Formalin-Fixed Paraffin-Embedded Archival Specimens. Journal of Proteome Research, 20(2), 1304-1312. [More Information]
Chatterjee, P., Fagan, A., Xiong, C., McKay, M., Bhatnagar, A., Wu, Y., Singh, A., Taddei, K., Martins, I., Gardener, S., Molloy, M., et al (2021). Presymptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy-Related Blood Metabolite Alterations. Journal of Alzheimer's Disease, 79(2), 895-903. [More Information]
Raajendiran, A., Krisp, C., de Souza, D., Ooi, G., Burton, P., Taylor, R., Molloy, M., Watt, M. (2021). Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points. American Journal of Physiology - Endocrinology and Metabolism, 320(6), E1068-E1084. [More Information]
Wright, B., Logel, D., Mirzai, M., Pascovici, D., Molloy, M., Jaschke, P. (2021). Proteomic and transcriptomic analysis of microviridae wX174 infection reveals broad upregulation of host escherichia coli membrane damage and heat shock responses. msystems, 6(3), e00046. [More Information]
Santos, J., Dolai, S., O'Rourke, M., Liu, F., Padula, M., Molloy, M., Milthorpe, B. (2021). Quantitative proteomic profiling of small molecule treated mesenchymal stem cells using chemical probes. International Journal of Molecular Sciences, 22(1), 1-20. [More Information]
Oh, B., Boyle, F., Pavlakis, N., Clarke, S., Eade, T., Hruby, G., Lamoury, G., Carroll, S., Morgia, M., Kneebone, A., Stevens, M., Molloy, M., Kong, B., Back, M., et al (2021). The gut microbiome and cancer immunotherapy: Can we use the gut microbiome as a predictive biomarker for clinical response in cancer immunotherapy? Cancers, 13(19), 4824. [More Information]
Oh, B., Eade, T., Lamoury, G., Carroll, S., Morgia, M., Kneebone, A., Hruby, G., Stevens, M., Boyle, F., Clarke, S., Molloy, M., Back, M., et al (2021). The gut microbiome and gastrointestinal toxicities in pelvic radiation therapy: A clinical review. Cancers, 13(10), 2353. [More Information]

show 12 more

2020

Gamage, H., Chong, R., Bucio-Noble, D., Kautto, L., Hardikar, A., Ball, M., Molloy, M., Packer, N., Paulsen, I. (2020). Changes in dietary fiber intake in mice reveal associations between colonic mucin O-glycosylation and specific gut bacteria. Gut Microbes, 12(1), 1802209. [More Information]
Voss, H., Wurlitzer, M., Smit, D., Ewald, F., Alawi, M., Spohn, M., Indenbirken, D., Omidi, M., David, K., Juhl, H., Molloy, M., et al (2020). Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer. Clinical and Experimental Metastasis, 37(6), 649-656. [More Information]
Piggin, C., Roden, D., Law, A., Molloy, M., Krisp, C., Swarbrick, A., Naylor, M., Kalyuga, M., Kaplan, W., Oakes, S., et al (2020). ELF5 modulates the estrogen receptor cistrome in breast cancer. PLoS Genetics, 16(1), 1-24. [More Information]
Bhatnagar, A., McKay, M., Arasaratnam, M., Crumbaker, M., Gurney, H., Molloy, M. (2020). Evaluating bioanalytical capabilities of paper spray ionization for abiraterone drug quantification in patient plasma. Journal of Mass Spectrometry, 55(10), e4584. [More Information]
Wright, B., Ruan, J., Molloy, M., Jaschke, P. (2020). Genome modularization reveals overlapped gene topology is necessary for efficient viral reproduction. ACS Synthetic Biology, 9(11), 3079-3090. [More Information]
Sahni, S., Nahm, C., Krisp, C., Molloy, M., Mehta, S., Maloney, S., Itchins, M., Pavlakis, N., Clarke, S., Chan, D., Gill, A., Howell, V., Samra, J., Mittal, A. (2020). Identification of Novel Biomarkers in Pancreatic Tumor Tissue to Predict Response to Neoadjuvant Chemotherapy. Frontiers in Oncology, 10, 1-10. [More Information]
Lyu, N., Rajendran, V., Diefenbach, R., Charles (nee Slaviero), K., Clarke, S., Engel, A., Rizos, H., Molloy, M., Wang, Y. (2020). Multiplex detection of ctdna mutations in plasma of colorectal cancer patients by pcr/sers assay. Nanotheranostics, 4(4), 224-232. [More Information]
Steffen, P., Wu, J., Hariharan, S., Voss, H., Raghunath, V., Molloy, M., Schlüter, H. (2020). Omixlitminer: A bioinformatics tool for prioritizing biological leads from ‘omics data using literature retrieval and data mining. International Journal of Molecular Sciences, 21(4), 1-11. [More Information]
Thejer, B., Adhikary, P., Kaur, A., Teakel, S., Van Oosterum, A., Seth, I., Pajic, M., Hannan, K., Pavy, M., Poh, P., Patrick, E., New, E., et al (2020). PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth. BMC Molecular and Cell Biology, 21(1), 1-24. [More Information]
Sahni, S., Krisp, C., Molloy, M., Nahm, C., Maloney, S., Gillson, J., Gill, A., Samra, J., Mittal, A. (2020). PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression. Biochimica et Biophysica Acta - General Subjects, 1864 (11), 1-6. [More Information]
Clarke, S., Burge, M., Feeney, K., Gibbs, P., Jones, K., Marx, G., Molloy, M., Price, T., Reece, W., Segelov, E., et al (2020). The prognostic role of inflammatory markers in patients with metastatic colorectal cancer treated with bevacizumab: A translational study [ASCENT]. PloS One, 15(3), e0229900. [More Information]

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2019

Bhatnagar, A., McKay, M., Thaysen-Andersen, M., Arasaratnam, M., Crumbaker, M., Gurney, H., Molloy, M. (2019). Bioanalytical evaluation of dried plasma spots for monitoring of abiraterone and Delta(4)-abiraterone from cancer patients. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1126-1127, 1-9. [More Information]
Bucio-Noble, D., Semaan, C., Molloy, M. (2019). Examining cellular responses to kinase drug inhibition through phosphoproteome mapping of substrates. Methods in Molecular Biology, 1888, 141-152. [More Information]
Arasaratnam, M., Crumbaker, M., Bhatnagar, A., McKay, M., Molloy, M., Gurney, H. (2019). Inter- and intra-patient variability in pharmacokinetics of abiraterone acetate in metastatic prostate cancer. Cancer Chemotherapy and Pharmacology, 84(1), 139-146. [More Information]
Noor, Z., Wu, J., Pascovici, D., Mohamedali, A., Molloy, M., Baker, M., Ranganathan, S. (2019). ISwathX: An interactive web-based application for extension of DIA peptide reference libraries. Bioinformatics, 35(3), 538-539. [More Information]
Wright, B., Kamath, K., Krisp, C., Molloy, M. (2019). Proteome profiling of Pseudomonas aeruginosa PAO1 identifies novel responders to copper stress. BMC Microbiology, 19(1), 69. [More Information]
Semaan, C., Henderson, B., Molloy, M. (2019). Proteomic screen with the proto-oncogene beta-catenin identifies interaction with Golgi coatomer complex I. Biochemistry and Biophysics Reports, 19, 1-6. [More Information]
McRobb, L., McKay, M., Gauden, A., Lee, V., Subramanian, S., Thomas, S., Wiedmann, M., Moutrie, V., Grace, M., Zhao, Z., Molloy, M., et al (2019). Radiation-stimulated translocation of CD166 and CRYAB to the endothelial surface provides potential vascular targets on irradiated brain arteriovenous malformations. International Journal of Molecular Sciences, 20(23), 1-13. [More Information]
Martinez-Aguilar, J., Molloy, M. (2019). Targeted mass spectrometry of S100 proteins. Methods in Molecular Biology, 1929, 663-678. [More Information]

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2018

Bezawork-Geleta, A., Wen, H., Dong, L., Yan, B., Vider, J., Boukalova, S., Krobova, L., Vanova, K., Zobalova, R., Sobol, M., et al (2018). Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints. Nature Communications, 9(1). [More Information]
Lin, C., Krisp, C., Packer, N., Molloy, M. (2018). Development of a data independent acquisition mass spectrometry workflow to enable glycopeptide analysis without predefined glycan compositional knowledge. Journal of Proteomics, 172, 68-75. [More Information]
Gamage, H., Tetu, S., Chong, R., Bucio-Noble, D., Rosewarne, C., Kautto, L., Ball, M., Molloy, M., Packer, N., Paulsen, I. (2018). Fiber supplements derived from sugarcane stem, wheat dextrin and psyllium husk have different in vitro effects on the human gut microbiota. Frontiers in Microbiology, 9(Issue JUL), 1618. [More Information]
Steffen, P., Krisp, C., Yi, W., Yang, P., Molloy, M., Schluter, H. (2018). Multi-laboratory analysis of the variability of shipped samples for proteomics following non-cooled international transport. Analytical Biochemistry, 548, 60-65. [More Information]
Lee, A., Rayner, S., Gwee, S., De Luca, A., Shahheydari, H., Sundaramoorthy, V., Ragagnin, A., Morsch, M., Radford, R., Galper, J., et al (2018). Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Cellular and Molecular Life Sciences, 75(2), 335-354. [More Information]
Semaan, C., Neilson, K., Brown, B., Molloy, M. (2018). Pharmacological inhibition of casein kinase 2 enhances the effectiveness of PI3K inhibition in colon cancer cells. Anticancer Research, 38(11), 6195-6200. [More Information]
Bucio-Noble, D., Kautto, L., Krisp, C., Ball, M., Molloy, M. (2018). Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model. Journal of Proteomics, 177, 1-10. [More Information]
Molloy, M., Engel, A. (2018). Precision medicine beyond medical oncology: using molecular analysis to guide treatments of colorectal neoplasia. Expert Review of Gastroenterology and Hepatology, 12(12), 1179-1181. [More Information]
Krisp, C., Parker, R., Pascovici, D., Hayward, N., Wilmott, J., Thompson, J., Mann, G., Long, G., Scolyer, R., Molloy, M. (2018). Proteomic phenotyping of metastatic melanoma reveals putative signatures of MEK inhibitor response and prognosis. British Journal of Cancer, 119(6), 713-723. [More Information]
Scott, C., de Souza, F., Aristizabal, V., Hethrington, L., Krisp, C., Molloy, M., Baker, M., Dell'Aqua, J. (2018). Proteomic profile of sex-sorted bull sperm evaluated by SWATH-MS analysis. Animal Reproduction Science, 198, 121-128. [More Information]
Simonian, M., Shirasaki, D., Lee, V., Bervini, D., Grace, M., Loo, R., Loo, J., Molloy, M., Stoodley, M. (2018). Proteomics identification of radiation-induced changes of membrane proteins in the rat model of arteriovenous malformation in pursuit of targets for brain AVM molecular therapy. Clinical Proteomics, 15(1), 43. [More Information]
Bhatnagar, A., McKay, M., Crumbaker, M., Ahire, K., Karuso, P., Gurney, H., Molloy, M. (2018). Quantitation of the anticancer drug abiraterone and its metabolite (delta)(4)-abiraterone in human plasma using high-resolution mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 154, 66-74. [More Information]

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2017

Mirzaei, M., Gupta, V., Chick, J., Greco, T., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., You, Y., Graham, S., et al (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Scientific Reports, 7(1), 1-16. [More Information]
Lee, A., Rayner, S., De Luca, A., Gwee, S., Morsch, M., Sundaramoorthy, V., Shahheydari, H., Ragagnin, A., Shi, B., Yang, S., et al (2017). Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex. Open Biology, 7(10), 1-11. [More Information]
Hogan, A., Don, E., Rayner, S., Lee, A., Laird, A., Watchon, M., Winnick, C., Tarr, I., Morsch, M., Fifita, J., Nicholson, G., et al (2017). Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human Molecular Genetics, 26(14), 2616-2626. [More Information]
Simonian, M., Ogorzalek Loo, R., Rannulu, N., Loo, J., Molloy, M., Stoodley, M. (2017). Identification of protein targets in cerebral endothelial cells for brain arteriovenous malformation (AVMs) molecular therapies. Clinical Proteomics, 14(1), 1-12. [More Information]
Wu, J., Pascovici, D., Ignjatovic, V., Song, X., Krisp, C., Molloy, M. (2017). Improving Protein Detection Confidence Using SWATH-Mass Spectrometry with Large Peptide Reference Libraries. Proteomics, 17(19), 1-5. [More Information]
McRobb, L., McKay, M., Gamble, J., Grace, M., Moutrie, V., Santos, E., Lee, V., Zhao, Z., Molloy, M., Stoodley, M. (2017). Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence. Aging, 9(4), 1248-1268. [More Information]
Collins, B., Hunter, C., Liu, Y., Schilling, B., Rosenberger, G., Bader, S., Chan, D., Gibson, B., Gingras, A., Held, J., et al (2017). Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry. Nature Communications, 8(1), 1-12. [More Information]
Agbaje, O., Thomas, D., Mclnerney, B., Molloy, M., Jacob, D. (2017). Organic macromolecules in shells of Arctica islandica: comparison with nacroprismatic bivalve shells. Marine Biology, 164(11), 1-13. [More Information]
Tan, S., Lee, A., Pascovici, D., Care, N., Birzniece, V., Ho, K., Molloy, M., Khan, A. (2017). Plasma biomarker proteins for detection of human growth hormone administration in athletes. Scientific Reports, 7(1), 1-12. [More Information]
Kamath, K., Krisp, C., Chick, J., Pascovici, D., Gygi, S., Molloy, M. (2017). Pseudomonas aeruginosa Proteome under Hypoxic Stress Conditions Mimicking the Cystic Fibrosis Lung. Journal of Proteome Research, 16(10), 3917-3928. [More Information]
Bjelosevic, S., Pascovici, D., Ping, H., Karlaftis, V., Zaw, T., Song, X., Molloy, M., Monagle, P., Ignjatovic, V. (2017). Quantitative age-specific variability of plasma proteins in healthy neonates, children and adults. Molecular and Cellular Proteomics, 16(5), 924-935. [More Information]
McRobb, L., Lee, V., Simonian, M., Zhao, Z., Thomas, S., Wiedmann, M., Amal Raj, J., Grace, M., Moutrie, V., McKay, M., et al (2017). Radiosurgery Alters the Endothelial Surface Proteome: Externalized Intracellular Molecules as Potential Vascular Targets in Irradiated Brain Arteriovenous Malformations. Radiation Research, 187(1), 66-78. [More Information]
Krisp, C., Molloy, M. (2017). SWATH mass spectrometry for proteomics of non-depleted plasma. Methods in Molecular Biology, 1619, 373-383. [More Information]
Mirzaei, M., Pascovici, D., Wu, J., Chick, J., Wu, Y., Cooke, B., Haynes, P., Molloy, M. (2017). TMT one-stop shop: From reliable sample preparation to computational analysis platform. In Shivakumar Keerthikumar and Suresh Mathivanan (Eds.), Proteome Bioinformatics, (pp. 45-66). New York: Springer. [More Information]
Johnson, A., Zaman, M., Veljanoski, F., Phrakaysone, A., Li, S., O'Doherty, P., Petersingham, G., Perrone, G., Molloy, M., Wu, M. (2017). Unravelling the role of protein kinase CK2 in metal toxicity using gene deletion mutants. Metallomics, 9(3), 301-308. [More Information]

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2016

Kao, S., Kirschner, M., Cooper, W., Tran, T., Burgers, S., Wright, C., Korse, T., van den Broek, D., Edelman, J., Vallely, M., McCaughan, B., Pavlakis, N., Clarke, S., van Zandwijk, N., Reid, G., et al (2016). A proteomics-based approach identifies secreted protein acidic and rich in cysteine as a prognostic biomarker in malignant pleural mesothelioma. British Journal of Cancer, 114(5), 524-531. [More Information]
Song, X., Amirkhani, A., Wu, J., Pascovici, D., Zaw, T., Xavier, D., Clarke, S., Molloy, M. (2016). Analytical performance of nano-LC-SRM using nondepleted human plasma over an 18-month period. Proteomics, 16(15-16), 2118-2127. [More Information]
Williams, K., Topp, S., Yang, S., Smith, B., Fifita, J., Warraich, S., Zhang, K., Farrawell, N., Vance, C., Dobson-Stone, C., Cole, N., Nicholson, G., et al (2016). CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nature Communications, 7, 1-8. [More Information]
Al-Eisawi, Z., Beale, P., Chan, C., Yu, J., Proschogo, N., Molloy, M., Huq, F. (2016). Changes in the in vitro activity of platinum drugs when administered in two aliquots. BMC Cancer, 16(1), 1-25. [More Information]
Morris, K., O'Meally, D., Zaw, T., Song, X., Gillett, A., Molloy, M., Polkinghorne, A., Belov, K. (2016). Characterisation of the immune compounds in koala milk using a combined transcriptomic and proteomic approach. Scientific Reports, 6, 1-14. [More Information]
Jamieson, C., Mills, K., Lui, C., Semaan, C., Molloy, M., Sharma, M., Forwood, J., Henderson, B. (2016). Characterization of a beta-catenin nuclear localization defect in MCF-7 breast cancer cells. Experimental Cell Research, 341(2), 196-206. [More Information]
Hayes, S., Haefliger, S., Harris, B., Pavlakis, N., Clarke, S., Molloy, M., Howell, V. (2016). Exhaled breath condensate for lung cancer protein analysis: a review of methods and biomarkers. Journal of Breath Research, 10(3), 1-26. [More Information]
Succar, P., Medynskyj, M., Breen, E., Batterham, T., Molloy, M., Herbert, B. (2016). Priming Adipose-Derived Mesenchymal Stem Cells with Hyaluronan Alters Growth Kinetics and Increases Attachment to Articular Cartilage. Stem Cells International, 2016, 1-13. [More Information]
Martinez-Aguilar, J., Clifton-Bligh, R., Molloy, M. (2016). Proteomics of thyroid tumours provides new insights into their molecular composition and changes associated with malignancy. Scientific Reports, 6, 1-12. [More Information]
Kamath, K., Pascovici, D., Penesyan, A., Goel, A., Venkatakrishnan, V., Paulsen, I., Packer, N., Molloy, M. (2016). Pseudomonas aeruginosa Cell Membrane Protein Expression from Phenotypically Diverse Cystic Fibrosis Isolates Demonstrates Host-Specific Adaptations. Journal of Proteome Research, 15(7), 2152-2163. [More Information]
Wu, J., Song, X., Pascovici, D., Zaw, T., Care, N., Krisp, C., Molloy, M. (2016). SWATH mass spectrometry performance using extended peptide MS/MS assay libraries. Molecular and Cellular Proteomics, 15(7), 2501-2514. [More Information]

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2015

Martinez-Aguilar, J., Clifton-Bligh, R., Molloy, M. (2015). A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours. BMC Cancer, 15(1), 1-14. [More Information]
Pascovici, D., Song, X., Solomon, P., Winterberg, B., Mirzaei, M., Goodchild, A., Stanley, W., Liu, J., Molloy, M. (2015). Combining Protein Ratio p-Values as a Pragmatic Approach to the Analysis of Multirun iTRAQ Experiments. Journal of Proteome Research, 14(2), 738-746. [More Information]
Mahon, K., Lin, H., Castillo, L., Lee, B., Lee-Ng, K., Chatfield, M., Chiam, K., Breit, S., Brown, D., Molloy, M., Marx, G., Pavlakis, N., Boyer, M., Stockler, M., Horvath, L., et al (2015). Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer. British Journal of Cancer, 112(8), 1340-1348. [More Information]
Meex, R., Hoy, A., Morris, A., Brown, R., Lo, J., Burke, M., Goode, R., Kingwell, B., Kraakman, M., Febbraio, M., et al (2015). Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism. Cell Metabolism, 22(6), 1078-1089. [More Information]
Penesyan, A., Kumar, S., Kamath, K., Shathili, A., Venkatakrishnan, V., Krisp, C., Packer, N., Molloy, M., Paulsen, I. (2015). Genetically and phenotypically distinct pseudomonas aeruginosa cystic fibrosis isolates share a core proteomic signature. PloS One, 10(10), e0138527. [More Information]
Percy, A., Tamura-Wells, J., Albar, J., Aloria, K., Amirkhani, A., Araujo, G., Arizmendi, J., Blanco, F., Canals, F., Cho, J., et al (2015). Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment. EuPA Open Proteomics.
Lin, C., Chik, J., Packer, N., Molloy, M. (2015). Multidimensional fractionation is a requirement for quantitation of golgi-resident glycosylation enzymes from cultured human cells. Journal of Proteome Research, 14(2), 747-755. [More Information]
Krisp, C., Yang, H., van Soest, R., Molloy, M. (2015). Online peptide fractionation using a multiphasic microfluidic liquid chromatography chip improves reproducibility and detection limits for quantitation in discovery and targeted proteomics. Molecular and Cellular Proteomics, 14(6), 1708-1719. [More Information]
Parker, R., Vella, L., Xavier, D., Amirkhani, A., Parker, J., Cebon, J., Molloy, M. (2015). Phosphoproteomic analysis of cell-based resistance to BRAF inhibitor therapy in melanoma. Frontiers in Oncology, 5(MAY), 95. [More Information]
Kamath, K., Kumar, S., Kaur, J., Venkatakrishnan, V., Paulsen, I., Nevalainen, H., Molloy, M. (2015). Proteomics of hosts and pathogens in cystic fibrosis. Proteomics - Clinical Applications, 9, 134-146. [More Information]
Jankova, L., Dent, O., Molloy, M., Chan, C., Chapuis, P., Howell, V., Clarke, S. (2015). Reporting in studies of protein biomarkers of prognosis in colorectal cancer in relation to the REMARK guidelines. Proteomics - Clinical Applications, 9(11-12), 1078-1086. [More Information]
Schilter, H., Cantemir-Stone, C., Leksa, V., Ohradanova-Repic, A., Findlay, A., Deodhar, M., Stockinger, H., Song, X., Molloy, M., Marsh, C., et al (2015). The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-?1 pathway in human lung fibroblasts. Immunology Letters, 165(2), 90-101. [More Information]

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2014

Chik, J., Zhou, J., Moh, E., Christopherson, R., Clarke, S., Molloy, M., Packer, N. (2014). Comprehensive glycomics comparison between colon cancer cell cultures and tumours: Implications for biomarker studies. Journal of Proteomics, 108, 146-162. [More Information]
Alexander, K., Ly, L., McKay, M., Mallawaaratchy, D., Mactier, S., Crossett, B., Molloy, M., Buckland, M., McDonald, K., Christopherson, R. (2014). Comprehensive proteomic profiling of bevacizumab-resistant glioblastoma multiforme. Neuro-Oncology, 16(Suppl 2), ii98-ii98.
Hayes, S., Hudson, A., Clarke, S., Molloy, M., Howell, V. (2014). From mice to men: GEMMs as trial patients for new NSCLC therapies. Seminars in Cell & Developmental Biology, 27, 118-127. [More Information]
Parker, R., Clifton-Bligh, R., Molloy, M. (2014). Phosphoproteomics of MAPK inhibition in BRAF mutated cells and a role for the lethal synergism of dual BRAF and CK2 inhibition. Molecular Cancer Therapeutics, 13(7), 1894-1906. [More Information]
Voros, A., Simm, R., Slamti, L., McKay, M., Hegna, I., Nielsen-LeRoux, C., Hassan, K., Paulsen, I., Molloy, M., et al (2014). SecDF as part of the sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins. PloS One, 9(8). [More Information]
Hart-Smith, G., Chia, S., Low, J., McKay, M., Molloy, M., Wilkins, M. (2014). Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-histone Protein Lysine Methyltransferase Activity. Journal of Proteome Research, 13(3), 1744-1756. [More Information]
Winterberg, B., Du Fall, L., Song, X., Pascovici, D., Care, N., Molloy, M., Ohms, S., Solomon, P. (2014). The necrotrophic effector protein SnTox3 re-programs metabolism and elicits a strong defence response in susceptible wheat leaves. BMC Plant Biology, 14(1), 215. [More Information]

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2013

Wu, J., Breen, E., Song, X., Cooke, B., Molloy, M. (2013). A protein annotation framework empowered with semantic reasoning. 12th International Semantic Web Conference, ISWC 2013, Australia: CEUR-WS.
Pascovici, D., Gardiner, D., Song, X., Breen, E., Solomon, P., Keighley, T., Molloy, M. (2013). Coverage and consistency: Bioinformatics aspects of the analysis of multirun iTRAQ experiments with wheat leaves. Journal of Proteome Research, 12(11), 4870-4881. [More Information]
Martinez-Aguilar, J., Molloy, M. (2013). Label-free selected reaction monitoring enables multiplexed quantitation of S100 protein isoforms in cancer cells. Journal of Proteome Research, 12(8), 3679-3688. [More Information]
Krisp, C., Jacobsen, F., McKay, M., Molloy, M., Steinstraesser, L., Wolters, D. (2013). Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients. Proteomics, 13(17), 2670-2681. [More Information]
Martinez-Aguilar, J., Chik, J., Nicholson, J., Semaan, C., McKay, M., Molloy, M. (2013). Quantitative mass spectrometry for colorectal cancer proteomics. Proteomics - Clinical Applications, 7(1-Feb), 42-54. [More Information]
Lee, A., Molloy, M., Baker, M., Kapur, A. (2013). Tandem ion exchange fractionation of chicken egg white reveals the presence of proliferative bioactivity. Journal of Agricultural and Food Chemistry, 61(17), 4079-4088. [More Information]
Molloy, M. (2013). Two-stepping to increase peptide spectra matches in large databases. Proteomics, 13(8), 1229-30. [More Information]

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2012

Nicholson, J., Neelagandan, K., Huart, A., Ball, K., Molloy, M., Hupp, T. (2012). An iTRAQ Proteomics Screen Reveals the Effects of the MDM2 Binding Ligand Nutlin-3 on Cellular Proteostasis. Journal of Proteome Research, 11(11), 5464-5478. [More Information]
Jankova, L., Robertson, G., Chan, C., Tan, K., Kohonen-Corish, M., Fung, C., Clarke, C., Lin, B., Molloy, M., Chapuis, P., Bokey, E., Dent, O., Clarke, S. (2012). Glutathione S-transferase Pi expression predicts response to adjuvant chemotherapy for stage C colon cancer: a matched historical control study. BMC Cancer, 12, 1-9. [More Information]
Krisp, C., McKay, M., Wolters, D., Molloy, M. (2012). Multidimensional protein identification technology-selected reaction monitoring improving detection and quantification for protein biomarker studies. Analytical Chemistry, 84(3), 1592-1600. [More Information]
Sigglekow, N., Pangon, L., Brummer, T., Molloy, M., Hawkins, N., Ward, R., Musgrove, E., Kohonen-Corish, M. (2012). Mutated in colorectal cancer protein modulates the NF?B pathway. Anticancer Research, 32(1), 73-79.
Kho, P., Jankova, L., Fung, C., Chan, C., Clarke, C., Lin, B., Robertson, G., Molloy, M., Chapuis, P., Bokey, E., Dent, O., Clarke, S. (2012). Overexpression of protein S100A4 is independently associated with overall survival in stage C colonic cancer but only in cytoplasm at the advancing tumour front. International Journal of Colorectal Disease, 27(11), 1409-1417. [More Information]
Randall, S., McKay, M., Pascovici, D., Mahon, K., Horvath, L., Clarke, S., Molloy, M. (2012). Remarkable temporal stability of high-abundance human plasma proteins assessed by targeted mass spectrometry. Proteomics - Clinical Applications, 6(11-12), 626-634. [More Information]
Sharma, M., Jamieson, C., Johnson, M., Molloy, M., Henderson, B. (2012). Specific Armadillo Repeat Sequences Facilitate beta-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358. Journal of Biological Chemistry, 287(2), 819-831. [More Information]
Krisp, C., Randall, S., McKay, M., Molloy, M. (2012). Towards clinical applications of selected reaction monitoring for plasma protein biomarker studies. Proteomics - Clinical Applications, 6(1-2), 42-59. [More Information]
Sherman, J., Molloy, M., Burlingame, A. (2012). Why complexity and entropy matter: Information, posttranslational modifications, and assay fidelity. Proteomics, 12(8), 1147-1150. [More Information]

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2011

Fung, D., Lo, A., Jankova, L., Clarke, S., Molloy, M., Robertson, G., Wilkins, M. (2011). Classification of Cancer Patients Using Pathway Analysis and Network Clustering. In Gerard Cagney, Andrew Emili (Eds.), Network Biology: Methods and Applications, (pp. 311-336). New York: Humana Press.
Tan, K., Jankova, L., Chan, C., Fung, C., Clarke, C., Lin, B., Robertson, G., Molloy, M., Chapuis, P., Bokey, E., Clarke, S., et al (2011). Clinicopathological correlates and prognostic significance of glutathione S-transferase Pi expression in 468 patients after potentially curative resection of node-positive colonic cancer. Histopathology, 59(6), 1057-1070. [More Information]
Yang, J., MacDougall, M., McDowell, M., Xi, L., Wei, R., Zavadoski, W., Molloy, M., Baker, J., Kuhn, M., Cabrera, O., et al (2011). Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC Genomics, 12, 1-14. [More Information]
Jankova, L., Chan, C., Fung, C., Song, X., Kwun, S., Cowley, M., Kaplan, W., Dent, O., Bokey, E., Chapuis, P., Robertson, G., Clarke, S., et al (2011). Proteomic comparison of colorectal tumours and non-neoplastic mucosa from paired patient samples using iTRAQ mass spectrometry. Molecular BioSystems, 7(11), 2997-3005. [More Information]
Dolai, S., Xu, Q., Liu, F., Molloy, M. (2011). Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells. Proteomics, 11(13), 2683-2692. [More Information]
Ali, N., Molloy, M. (2011). Quantitative phosphoproteomics of transforming growth factor-Î² signaling in colon cancer cells. Proteomics, 11(16), 3390-3401. [More Information]

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2010

Fung, C., Chan, C., Jankova, L., Dent, O., Robertson, G., Molloy, M., Bokey, E., Chapuis, P., Lin, B., Clarke, S. (2010). Clinicopathological correlates and prognostic significance of maspin expression in 450 patients after potentially curative resection of node-positive colonic cancer. Histopathology, 56(3), 319-330. [More Information]
Lam, F., Jankova, L., Dent, O., Molloy, M., Kwun, S., Clarke, C., Chapuis, P., Robertson, G., Beale, P., Clarke, S., Bokey, E., Chan, C. (2010). Identification of distinctive protein expression patterns in colorectal adenoma. Proteomics - Clinical Applications, 4(1), 60-70. [More Information]

2009

Zhao, L., Lee, B., Brown, D., Molloy, M., Marx, G., Pavlakis, N., Boyer, M., Stockler, M., Kaplan, W., Breit, S., et al (2009). Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling. Cancer Research, 69(19), 7696-7703. [More Information]

2007

McKay, M., Sherman, J., Laver, M., Baker, M., Clarke, S., Molloy, M. (2007). The development of multiple reaction monitoring assays for liver-derived plasma proteins. Proteomics - Clinical Applications, 1(12), 1570-1581. [More Information]

Selected Grants

2025

Preventing Bowel Cancers with Novel Molecular Tests, Molloy M, Tour de Cure Ltd/Research Matching Grant

2023

Rewarding Research 2024, Molloy M, Faculty of Medicine and Health/FMH Rewarding Research Success
Externally funded position-Julius Woongki Kim, Molloy M, Northern Sydney Local Health District (NSLHD)/Externally Funded Position
IVIS Lumina Series-III In Vivo Imaging System, Molloy M, DVC Research/Equipment Grant
Improving outcomes for patients with colorectal liver metastases, Molloy M, Hughes T, Wong G, Tour de Cure Ltd/Research Matching Grant

2022

Blood test for diagnosis of bowel polyps and cancer. (With industry partner Sangui Bio Pty Ltd), Molloy M, DVC Research/NSW Boosting Business Program
Laser capture microdissection microscope for spatial molecular profiling of tissues, Molloy M, Gill A, Sahni S, Sue C, Braet F, Ian Potter Foundation/Research Grants
Development of Biomarker Tests for Early Detection/Diagnosis of Pancreatic Cancer, Mittal A, Sahni S, Molloy M, PanKind Australian Pancreatic Cancer Foundation Ltd/Research support

2021

Molecular analysis of bowel polyps to prevent malignancy, Molloy M, Tour de Cure Ltd/Research Matching Grant

2020

Penelope Morris Foundation Scholarship, Molloy M, The Penelope Morris Foundation/Donation

2019

Integrative molecular landscape of premalignant bowel adenomas and disease risk stratification, Molloy M, Engel A, Li J, Cancer Council NSW/Project Grant
Investigating the prognostic contribution of immune cell infiltration in rectal cancer, Molloy M, Steffen P, Steffen P, Cancer Institute NSW/Early Career Fellowship
Molecular analysis of adenomatous polyps to define disease risk, Molloy M, Sydney Vital Translational Cancer Research/Research Funding Award

2018

Molecular profiling of bowel polyps as a tool to define colonoscopic surveillance intervals, Engel A, Molloy M, Yang J, Department of Health and Aged Care (Federal)/MRFF - Rapid Applied Research Translation (RART) - Sydney Health Partners
RIG Funding for Research Assistant in MASS SPECTROMETRY 2018-2019, Molloy M, Sydney Vital Translational Cancer Research/CINSW RIG Scheme
Molecular analysis to refine risk of dissemination in early stage colorectal tumours and transformation potential of colorectal polyps, Molloy M, Engel A, Colorectal Surgical Society of Australia and New Zealand Foundation/Research Support

2017

Lawrence Penn Chair of Bowel Cancer Research, Molloy M, Northern Clinical School/Research Support
Proteome homeostasis dysfunction in axon terminals as a cause of MND, Molloy M, Yerbury J, Motor Neurone Disease Research Institute of Australia/Motor Neurone Disease Research Grants

In the media

https://www.bowelcanceraustralia.org/research/lawrence-penn-chair-of-bowel-cancer-research

https://www.9news.com.au/national/bowel-cancer-health-news-screening-polyps-sydney-university-symptons/75daf388-0483-4848-b184-883ba32cfc5a

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Professor Mark Molloy

Publications

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Selected Grants

2025

2023

2022

2021

2020

2019

2018

2017

In the media