Dr Marie-Christine Morel-Kopp
Medicine, Northern Clinical School
Senior Research Officer in the Department of Haematology, Royal North Shore Hospital. Research interests are essentially on platelet and coagulation disorders. In 1990, completed her PhD at the Pierre et Marie Curie University in Paris, under the supervision of Dr Cecile Kaplan on ¿Anti-GP IIbIIIa complex monoclonal antibodies: tools to study thrombopathies¿. From 1996 to 1998, undertook postdoctoral studies with Dr Nelly Kieffer in Luxemburg on platelet integrins and signaling. Moved to Sydney in 1999 and started work with Dr Chris Ward to develop a new research facility: the Northern Blood Research Centre, to foster basic and translational haematology research on the northern campus.
Thrombosis and Haemostasis
Platelet and erythrocyte functional defects caused by mutations of transcription factor gfi1b
Massively parrallel sequencing to decipher uncharacterised inherited platelet disorders
Publications
Book Chapters
- Rabbolini, D., Morel-Kopp, M., Gabrielli, S., Chen, Q., Stevenson, W., Ward, C. (2015). DNA-based Diagnosis of Uncharacterized Inherited Macrothrombocytopenias Using Next-generation Sequencing Technology with a Candidate Gene Array. In Jerzy K Kulski (Eds.), Next Generation Sequencing: Advances, Applications and Challenges, (pp. 387-408). Rijeka, Croatia: InTech Publishers. [More Information]
- Pepperell, D., Morel-Kopp, M., Ward, C. (2014). Clinical Application of Fibrinolytic Assays. In Krasimir Kolev (Eds.), Fibrinolysis and Thrombolysis, (pp. 125-162). Rijeka: InTech Publishers. [More Information]
Journals
- Morel-Kopp, M. (2023). Functional Testing for Heparin-Induced Thrombocytopenia Using Whole Blood Multiplate Impedance Aggregometry. Methods in Molecular Biology, 2663, 417-428. [More Information]
- Hsu, H., Chan, M., Armstrong, P., Crescente, M., Donikian, D., Kondo, M., Brighton, T., Chen, V., Chen, Q., Connor, D., Morel-Kopp, M., Stevenson, W., Ward, C., Rabbolini, D., et al (2022). A pilot study assessing the implementation of 96-well plate-based aggregometry (Optimul) in Australia. Pathology, 54(6), 746-754. [More Information]
- Rabbolini, D., Liang, H., Morel-Kopp, M., Connor, D., Whittaker, S., Dunkley, S., Donikian, D., Kondo, M., Chen, W., Stevenson, W., Campbell, H., Ward, C., Chen, V., et al (2022). Building platelet phenotypes: diaphanous-related formin 1 (DIAPH1)-related disorder. Platelets, 33(3), 432-442. [More Information]
2023
- Morel-Kopp, M. (2023). Functional Testing for Heparin-Induced Thrombocytopenia Using Whole Blood Multiplate Impedance Aggregometry. Methods in Molecular Biology, 2663, 417-428. [More Information]
2022
- Hsu, H., Chan, M., Armstrong, P., Crescente, M., Donikian, D., Kondo, M., Brighton, T., Chen, V., Chen, Q., Connor, D., Morel-Kopp, M., Stevenson, W., Ward, C., Rabbolini, D., et al (2022). A pilot study assessing the implementation of 96-well plate-based aggregometry (Optimul) in Australia. Pathology, 54(6), 746-754. [More Information]
- Rabbolini, D., Liang, H., Morel-Kopp, M., Connor, D., Whittaker, S., Dunkley, S., Donikian, D., Kondo, M., Chen, W., Stevenson, W., Campbell, H., Ward, C., Chen, V., et al (2022). Building platelet phenotypes: diaphanous-related formin 1 (DIAPH1)-related disorder. Platelets, 33(3), 432-442. [More Information]
- Faleschini, M., Papa, N., Morel-Kopp, M., Marconi, C., Giangregorio, T., Melazzini, F., Bozzi, V., Seri, M., Noris, P., Pecci, A., et al (2022). Dysregulation of oncogenic factors by GFI1B p32: investigation of a novel GFI1B germline mutation. Haematologica, 107(1), 260-267. [More Information]
2021
- Kott, K., Morel-Kopp, M., Vernon, S., Takagi, Y., Di Bartolo, B., Peter, K., Yang, J., Grieve, S., Ward, C., Figtree, G. (2021). Association of global coagulation profiles with cardiovascular risk factors and atherosclerosis: A sex disaggregated analysis from the bioheart-ct study. Journal of the American Heart Association, 10(20), e020604. [More Information]
- Megy, K., Downes, K., Morel-Kopp, M., Bastida, J., Brooks, S., Bury, L., Leinoe, E., Gomez, K., Morgan, N., Othman, M., et al (2021). GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic, and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis. Journal of Thrombosis and Haemostasis, 19(10), 2612-2617. [More Information]
- Kalev-Zylinska, M., Morel-Kopp, M., Ward, C., Hearn, J., Hamilton, J., Bogdanova, A. (2021). Ionotropic glutamate receptors in platelets: opposing effects and a unifying hypothesis. Platelets, 32(8), 998-1008. [More Information]
2020
- Rabbolini, D., Connor, D., Morel-Kopp, M., Donikian, D., Kondo, M., Chen, W., Alessi, M., Stevenson, W., Chen, V., Joseph, J., Ward, C., et al (2020). An integrated approach to inherited platelet disorders: results from a research collaborative, the Sydney Platelet Group. Pathology, 52(2), 243-255. [More Information]
- Park, Y., Penumarthy, R., Sun, P., Kang, C., Morel-Kopp, M., Downing, J., Green, T., Immanuel, T., Ward, C., Young, D., et al (2020). Platelet-reactive antibodies in patients after ischaemic stroke—an epiphenomenon or a natural protective mechanism. International Journal of Molecular Sciences, 21(21), 1-16. [More Information]
- Tang, C., Rabbolini, D., Morel-Kopp, M., Connor, D., Crispin, P., Ward, C. (2020). The clinical heterogeneity of RUNX1 associated familial platelet disorder with predisposition to myeloid malignancy - A case series and review of the literature. Research and Practice in Thrombosis and Haemostasis, 4(1), 106-110. [More Information]
2019
- Joseph, J., Rabbolini, D., Enjeti, A., Favaloro, E., Kopp, M., McRae, S., Pasalic, L., Tan, C., Ward, C., Chong, B. (2019). Diagnosis and management of heparin-induced thrombocytopenia: a consensus statement from the Thrombosis and Haemostasis Society of Australia and New Zealand HIT Writing Group. Medical Journal of Australia, 210(11), 509-516. [More Information]
2018
- Balendran, S., Harrison, A., Morel-Kopp, M., Ward, C., Forsyth, C. (2018). Delayed-onset heparin-induced thrombocytopenia complicated by arterial and venous thromboses. Internal Medicine Journal, 48(1), 98-100. [More Information]
- Rabbolini, D., Chun, Y., Latimer, M., Kunishima, S., Fixter, K., Valecha, B., Tan, P., Chew, L., Kile, B., Burt, R., Gabrielli, S., Chen, Q., Stevenson, W., Ward, C., Morel-Kopp, M., et al (2018). Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia. Platelets, 29(8), 793-800. [More Information]
- Fixter, K., Rabbolini, D., Valecha, B., Morel-Kopp, M., Gabrielli, S., Chen, Q., Stevenson, W., Ward, C. (2018). Mean platelet diameter measurements to classify inherited thrombocytopenias. International Journal of Laboratory Hematology, 40(2), 187-195. [More Information]
2017
- Rabbolini, D., Gardiner, E., Morel-Kopp, M., Dunkley, S., Jahangiri, A., Lee, C., Stevenson, W., Ward, C. (2017). Anti-glycoprotein VI mediated immune thrombocytopenia: An under-recognized and significant entity? Research and Practice in Thrombosis and Haemostasis, 1(2), 291-295. [More Information]
- Rabbolini, D., Morel-Kopp, M., Ward, C., Stevenson, W. (2017). GFI1B variants associated with thrombocytopenia. Platelets, 28(5), 525-527. [More Information]
- Green, T., Hamilton, J., Morel-Kopp, M., Zheng, Z., Chen, T., Hearn, J., Sun, P., Flanagan, J., Young, D., Barber, P., Ward, C., et al (2017). Inhibition of NMDA receptor function with an anti-GluN1-S2 antibody impairs human platelet function and thrombosis. Platelets, 28(8), 799-811. [More Information]
2016
- Dengate, A., Morel-Kopp, M., Beatty, J., Barrs, V., Braddock, J., Churcher, R., Wilson, B., Ward, C. (2016). Differentiation between dogs with thrombosis and normal dogs using the overall hemostasis potential assay. Journal of Veterinary Emergency and Critical Care, 26(3), 446-452. [More Information]
- Nguyen, T., Pepperell, D., Morel-Kopp, M., Cumming, R., Ward, C., Hilmer, S. (2016). Effect of Frailty and Age on Platelet Aggregation and Response to Aspirin in Older Patients with Atrial Fibrillation: A Pilot Study. Cardiology and Therapy, 5(1), 51-62. [More Information]
- Morel-Kopp, M., Mullier, F., Gkalea, V., Bakchoul, T., Minet, V., Elalamy, I., Ward, C. (2016). Heparin-induced multi-electrode aggregometry method for heparin-induced thrombocytopenia testing: communication from the SSC of the ISTH. Journal of Thrombosis and Haemostasis, 14(12), 2548-2552. [More Information]
2015
- Rabbolini, D., Morel-Kopp, M., Gabrielli, S., Chen, Q., Stevenson, W., Ward, C. (2015). DNA-based Diagnosis of Uncharacterized Inherited Macrothrombocytopenias Using Next-generation Sequencing Technology with a Candidate Gene Array. In Jerzy K Kulski (Eds.), Next Generation Sequencing: Advances, Applications and Challenges, (pp. 387-408). Rijeka, Croatia: InTech Publishers. [More Information]
- Kamal, T., Green, T., Morel-Kopp, M., Ward, C., McGregor, A., McGlashan, S., Bohlander, S., Browett, P., Teague, L., During, M., et al (2015). Inhibition of glutamate regulated calcium entry into leukemic megakaryoblasts reduces cell proliferation and supports differentiation. Cellular Signalling, 27(9), 1860-1872. [More Information]
- Qiao, J., Davis, A., Morel-Kopp, M., Ward, C., Gardiner, E., Andrews, R. (2015). Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ibbeta in a patient with Bernard-Soulier syndrome. Annals of Hematology, 94(12), 2069-2071. [More Information]
2014
- Pepperell, D., Morel-Kopp, M., Ward, C. (2014). Clinical Application of Fibrinolytic Assays. In Krasimir Kolev (Eds.), Fibrinolysis and Thrombolysis, (pp. 125-162). Rijeka: InTech Publishers. [More Information]
- Rabbolini, D., Morel-Kopp, M., Stevenson, W., Ward, C. (2014). Inherited Macrothrombocytopenias. Seminars in Thrombosis and Hemostasis, 40(7), 774-784. [More Information]
- Kalev-Zylinska, M., Green, T., Morel-Kopp, M., Sun, P., Park, Y., Lasham, A., During, M., Ward, C. (2014). N-methyl-d-aspartate receptors amplify activation and aggregation of human platelets. Thrombosis Research, 133, 837-847. [More Information]
2013
- Reddel, C., Curnow, J., Voitl, J., Rosenov, A., Pennings, G., Morel-Kopp, M., Brieger, D. (2013). Detection of hypofibrinolysis in stable coronary artery disease using the overall haemostatic potential assay. Thrombosis Research, 131(5), 457-462. [More Information]
- McEwen, B., Morel-Kopp, M., Chen, W., Tofler, G., Ward, C. (2013). Effects of Omega-3 Polyunsaturated Fatty Acids on Platelet Function in Healthy Subjects and Subjects with Cardiovascular Disease. Seminars in Thrombosis and Hemostasis, 39(1), 25-32. [More Information]
- Dengate, A., Morel-Kopp, M., Beatty, J., Barrs, V., Braddock, J., Churcher, R., Wilson, B., Ward, C. (2013). Evaluation and modification of the overall hemostasis potential assay for use with canine plasma. American Journal of Veterinary Research, 74(12), 1493-1498. [More Information]
2012
- McEwen, B., Phillips, C., Morel-Kopp, M., Yee, B., Sullivan, D., Ward, C., Tofler, G., Grunstein, R. (2012). Diurnal changes and levels of fibrin generation are not altered by continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA). Journal of Thrombosis and Haemostasis, 108(4), 701-709. [More Information]
- Buckley, T., Stannard, A., Bartrop, R., McKinley, S., Ward, C., Mihailidou, A., Morel-Kopp, M., Spinaze, M., Tofler, G. (2012). Effect of Early Bereavement on Heart Rate and Heart Rate Variability. American Journal of Cardiology, 110(9), 1378-1383. [More Information]
- Phillips, C., McEwen, B., Morel-Kopp, M., Yee, B., Sullivan, D., Ward, C., Tofler, G., Grunstein, R. (2012). Effects of continuous positive airway pressure on coagulability in obstructive sleep apnoea: a randomised, placebo-controlled crossover study. Thorax, 67(7), 639-644. [More Information]
2011
- Aboud, M., Morel-Kopp, M., Ward, C., Coyle, L. (2011). False negative or false positive: laboratory diagnosis of LA at the time of commencement of anticoagulant: reply to a rebuttal. Journal of Thrombosis and Haemostasis, 9(7), 1436-1437. [More Information]
- Buckley, T., Mihailidou, A., Bartrop, R., McKinley, S., Ward, C., Morel-Kopp, M., Spinaze, M., Tofler, G. (2011). Haemodynamic Changes During Early Bereavement: Potential Contribution to Increased Cardiovascular Risk. Heart, Lung, and Circulation, 20(2), 91-98. [More Information]
- Morel-Kopp, M., Aboud, M., Tan, C., Kulathilake, C., Ward, C. (2011). Heparin-induced thrombocytopenia: Evaluation of IgG and IgGAM ELISA assays. International Journal of Laboratory Hematology, 33(3), 245-250. [More Information]
2010
- Buckley, T., Bartrop, R., McKinley, S., Ward, C., Mihailidou, A., Morel-Kopp, M., Spinaze, M., Tofler, G. (2010). Early bereavement is associated with increased heart rate and reduced heart rate variability. Circulation, 122, A14660.
- McEwen, B., Morel-Kopp, M., Tofler, G., Ward, C. (2010). Effect of Omega-3 Fish Oil on Cardiovascular Risk in Diabetes. The Diabetes Educator, 36(4), 565-584. [More Information]
- Aboud, M., Morel-Kopp, M., Ward, C., Coyle, L. (2010). False-negative or false-positive: laboratory diagnosis of lupus anticoagulant at the time of commencement of anticoagulant. Journal of Thrombosis and Haemostasis, 8(9), 2070-2073. [More Information]
2009
- Morel-Kopp, M., Buckley, T., Chen, Q., Tofler, G., McKinley, S., Bartrop, R., Ward, C. (2009). An Evaluation of thrombotic changes in bereavement. Journal of Thrombosis and Haemostasis, 7(2), 456-456.
- Mihailidou, A., Buckley, T., Spinaze, M., Roche, D., Bramwell, M., McKinley, S., Morel-Kopp, M., Ward, C., Bartrop, R., Tofler, G. (2009). Increased blood pressure load during bereavement: Potential mechanism for increased cardiovascular risk. Hypertension.
- Buckley, T., Bartrop, R., McKinley, S., Ward, C., Bramwell, M., Roche, D., Mihailidou, A., Morel-Kopp, M., Spinaze, M., Hocking, B., Tennant, C., Tofler, G., et al (2009). Prospective study of early bereavement on psychological and behavioural cardiac risk factors. Internal Medicine Journal, 39(6), 370-378. [More Information]
2008
- Weir, C., Morel-Kopp, M., Gill, A., Tinworth, K., Ladd, L., Hunyor, S., Ward, C. (2008). Mesenchymal Stem Cells: Isolation, Characterisation and In Vivo Fluorescent Dye Tracking. Heart, Lung, and Circulation, 17(5), 395-403. [More Information]
2007
- Buckley, T., Bartrop, R., McKinley, S., Goldstone, K., Ward, C., Bramwell, M., Hocking, B., Roche, D., Mihailidou, A., Morel-Kopp, M., Spinaze, M., Tennant, C., Tofler, G. (2007). An evaluation of psychological and behavioural factors during bereavement. Heart, Lung, and Circulation, 16(S1), S201.
- Liang, H., Morel-Kopp, M., Curtin, J., Wilson, M., Hewson, J., Chen, W., Ward, C. (2007). Heterozygous loss of platelet glycoprotein (GP) Ib-V-IX variably affects platelet function in velocardiofacial syndrome (VCFS) patients. Thrombosis and Haemostasis, 98(6), 1298-1308. [More Information]
- Buckley, T., Morel-Kopp, M., Bartrop, R., McKinley, S., Ward, C., Mihailidou, A., Goldstone, K., Bramwell, M., Hocking, B., Roche, D., Spinaze, M., Tofler, G., et al (2007). Inflammatory and thrombotic changes in bereavement in bereavement: A potential mechanism of increased cardiovascular risk. Circulation, 116(16), 844.
2006
- Aw, T., Liew, D., Tofler, G., Schneider, H., Morel-Kopp, M., Billah, B., Krum, H. (2006). Can the blood pressure effects of COX-2 selective inhibitors be explained by changes in plasma aldosterone levels? Journal of Hypertension, 24(10), 1979-1984. [More Information]
- Leow, N., Morel-Kopp, M., Woodward, M., Chen, Q., Tofler, G., Taylor, B. (2006). The relationship between cotinine and periodontal disease. Annals of the Royal Australasian College of Dental Surgeons, 18(September 2006), 51-52. [More Information]
2005
- Liang, H., Morel-Kopp, M., Clemetson, J., Clemetson, K., Kekomaki, R., Kroll, H., Michaelides, K., Tuddenham, E., Vanhoorelbeke, K., Ward, C. (2005). A common ancestral glycoprotein (GP) 9 1828A>G (Asn45Ser) gene mutation occurring in European families from Australia and Northern Europe with Bernard-Soulier syndrome (BSS). Thrombosis and Haemostasis, 94(3), 599-605. [More Information]
- McLean, L., Tennant, C., Ward, C., Berry, G., Maddison, V., Chen, W., Morel-Kopp, M. (2005). Is fibrinogen a mediating risk factor between depression and cardiovascular disease? Preliminary results of a longitudinal case-control study. Australian and New Zealand Journal of Psychiatry, 39(Supplement 1, Point 309), A120-A121.
- Ward, C., Curnow, J., Roddie, C., Mackinlay, N., Aboud, M., Morel-Kopp, M. (2005). Use of a global coagulation assay to manage hypercoagulable states in pregnancy. Thrombosis Research, 115(s1), 147-147.
2004
- Chen, V., Thrift, K., Morel-Kopp, M., Jackson, D., Ward, C., Flower, R. (2004). An Immediate Hemolytic Reaction Induced By Repeated Administration Of Oxaliplatin. Transfusion, 44(6), 838-843. [More Information]
- Halle, L., H., B., Martageix, C., Bianchi, F., Le T Kim, T., Morel-Kopp, M., Soulier, J., Tetaria, C., Kaplan, C. (2004). Superflux and Silence in Shakespeare's King Lear. Tissue Antigens: immune response genetics, 63(1), 34-40. [More Information]
Selected Grants
2018
- Diagnose and Inform: a genetic testing pathway for undiagnosed bleeding disorders coupled with laboratory validation of identified genetic variants, Morel-Kopp M, Ward C, Stevenson W, Haemophilia Foundation Australia/Research Support
2014
- Research project Prof Heimburger Award, Pepperell D, Morel-Kopp M, CSL Behring GmbH/Prof Heimburger Award