Associate Professor Martin Krause
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Associate Professor Martin Krause

Clinical Associate Professor
Medicine, Northern Clinical School
Phone
+61 2 9463 1733
Fax
+61 2 9463 1071
Associate Professor Martin Krause

Dr Martin Krause received his medical degree from one of the most prestigious and oldest Medical Schools in the world - the University of Heidelberg, which was founded in 1386.

He started his training in Neurology in 1995 at the Neurology Department of the University Hospitals Heidelberg, Germany under the mentorship of Prof Werner Hacke a world leader in stroke therapy.

He finalized his medical these and received the Dr. Med. with magna cum laude on the topic of diagnostic accuracy of telemedicine and picture archiving and communication systems in 1997.

Dr Krause’s main focus of research was initially movement disorders. He was so fortunate to work together with the neurosurgeon Prof Volker Tronnier. Dr Tronnier was a pioneer of functional neurosurgery and deep brain stimulation (DBS). This research group explored DBS for dystonia which proved to be the first effective therapy in generalized dystonia. Dr Krause was founding member of the German Parkinson Competence Network, which linked clinical research institutions in Europe together and enabled large-scale clinical trials. In this group the first randomized controlled trial of DBS proved the effectiveness of DBS for Parkinson’s disease and different types of dystonia.

He had extensive training in neurophysiology and Botox therapy under the mentorship of Prof HM Meinck who had a special interest in stiff-man disease and functional disorders. Dr Krause was accredited as board certified neurophysiologist in 2001.

He further engaged in 2 years of neuro-critical care training in the largest neurological Intensive Care Unit.

Very early on Dr Krause was involved in acute stroke treatment and participated in all three ECASS trials, which led to the first effective therapy for acute stroke. He completed his training with neurovascular ultrasound training in 2005.

Following the comprehensive German specialist exit exam Dr Krause was registered as board certified Neurologists and Neurophysiologist in 2005.

He represented over 1000 physicians and surgeons in Heidelberg in the staff council. He was part of a small group negotiating new employment terms for doctors abandoning 36 hours shifts and standardizing training streams.

In 2007 Dr Krause accepted an offer as Associated Professor of Medicine by the University of Sydney as a full time medical academic. He was part of the Nepean Clinical School. He furthered the acute stroke service in Nepean Hospital and introduced transcranial ultrasound to diagnostic repertoire of neurovascular ultrasound in Nepean.

In 2011 Dr Krause was appointed as Stroke Unit Head in Royal North Shore Hospital and Neuroscience Director for the Northern Sydney Local Health District.

In 2015 he was appointed Head of Department of Neurology at Royal North Shore Hospital.

He has authored 45 peer-reviewed publications of which three were in the prestigious New England Journal of Medicine.

He has received numerous prizes for his work both nationally and internationally and is a frequent presenter at national and international conference and scientific meetings.

Dr Krause is a member of the strategic working party of the Agency of Clinical Innovation and the State-wide Stroke Service. He is a member of the Stroke Society of Australasia and the Stroke Research Network.

He is a member of the American Heart Association, the German Society of Neurology as well as the Australian New-Zealand Association of Neurologists.

Acute Stroke Therapy

Stroke Imaging

Stroke Prevention

Movement Disorders

Dystonia

Parkinson Disease

Behavioural Neurology

Stroke

Movement Disorders

Parkinson Disease

Tremors

Dystonia

Behavioural Neurology

Neurocritical Care

Status epilepticus

Functional Disorders

Publications

Journals

  • Marko, M., Swartz, R., Hill, M., Coutts, S., Moreau, F., Boulanger, J., Camden, M., Campbell, B., Field, T., Krause, M., et al (2024). Clinical Predictors of Acute Ischemia in Patients with Low-Risk Neurological Deficits. Canadian Journal of Neurological Sciences. [More Information]
  • Chatterton, S., Xi, S., Jia, J., Krause, M., Long, G., Atkinson, V., Menzies, A., Fernando, S., Boyle, T., Kwok, S., Duggins, A., Karikios, D., Parratt, J. (2023). Case series: Immune checkpoint inhibitor-induced transverse myelitis. Frontiers in Neurology, 14. [More Information]
  • Baird-Gunning, J., Priglinger-Coorey, M., Krause, M. (2020). Acute stroke: Preventing stroke and managing complications. Medicine Today, 21(5), 10-19.

2024

  • Marko, M., Swartz, R., Hill, M., Coutts, S., Moreau, F., Boulanger, J., Camden, M., Campbell, B., Field, T., Krause, M., et al (2024). Clinical Predictors of Acute Ischemia in Patients with Low-Risk Neurological Deficits. Canadian Journal of Neurological Sciences. [More Information]

2023

  • Chatterton, S., Xi, S., Jia, J., Krause, M., Long, G., Atkinson, V., Menzies, A., Fernando, S., Boyle, T., Kwok, S., Duggins, A., Karikios, D., Parratt, J. (2023). Case series: Immune checkpoint inhibitor-induced transverse myelitis. Frontiers in Neurology, 14. [More Information]

2020

  • Baird-Gunning, J., Priglinger-Coorey, M., Krause, M. (2020). Acute stroke: Preventing stroke and managing complications. Medicine Today, 21(5), 10-19.
  • Campbell, B., Mitchell, P., Churilov, L., Yassi, N., Kleinig, T., Dowling, R., Yan, B., Bush, S., Thijs, V., Scroop, R., Krause, M., et al (2020). Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion before Thrombectomy in Patients with Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial. JAMA - Journal of the American Medical Association, 23(13), 1257-1265. [More Information]

2019

  • Jala, S., Giaccari, S., Passer, M., Bertmar, C., Day, S., Griffith, D., Krause, M. (2019). "In Safe Hands - A costly integrated care program with limited benefits in stroke unit care". Journal of Clinical Neuroscience, 59, 84-88. [More Information]
  • Coutts, S., Moreau, F., Asdaghi, N., Boulanger, J., Camden, M., Campbell, B., Demchuk, A., Field, T., Goyal, M., Krause, M., et al (2019). Rate and Prognosis of Brain Ischemia in Patients with Lower-Risk Transient or Persistent Minor Neurologic Events. JAMA Neurology, 76(12), 1439-1445. [More Information]
  • Ma, H., Campbell, B., Parsons, M., Churilov, L., Levi, C., Hsu, C., Kleinig, T., Wijeratne, T., Curtze, S., Krause, M., et al (2019). Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. New England Journal of Medicine, 380(19), 1795-1803. [More Information]

2018

  • Yu, S., Arima, H., Bertmar, C., Clarke, S., Herkes, G., Krause, M. (2018). Neutrophil to lymphocyte ratio and early clinical outcomes in patients with acute ischemic stroke. Journal of the Neurological Sciences, 387, 115-118. [More Information]
  • Campbell, B., Mitchell, P., Churilov, L., Yassi, N., Kleinig, T., Yan, B., Dowling, R., Bush, S., Dewey, H., Thijs, V., Krause, M., et al (2018). Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): A multicenter, randomized, controlled study. International Journal of Stroke, 13(3), 328-334. [More Information]
  • Campbell, B., Mitchell, P., Churilov, L., Yassi, N., Kleinig, T., Dowling, R., Yan, B., Bush, S., Dewey, H., Thijs, V., Krause, M., et al (2018). Tenecteplase versus alteplase before thrombectomy for ischemic stroke. New England Journal of Medicine, 378(17), 1573-1582. [More Information]

2017

  • Campbell, B., Mitchell, P., Churilov, L., Keshtkaran, M., Hong, K., Kleinig, T., Dewey, H., Yassi, N., Yan, B., Krause, M., et al (2017). Endovascular thrombectomy for ischemic stroke increases disability-free survival, quality of life, and life expectancy and reduces cost. Frontiers in Neurology, 8(DEC), 1-7. [More Information]

2016

  • Yu, S., Arima, H., Bertmar, C., Hirakawa, Y., Priglinger, M., Evans, K., Krause, M. (2016). Depression but not anxiety predicts recurrent cerebrovascular events. Acta Neurologica Scandinavica, 134(1), 29-34. [More Information]
  • O'Brien, E., Priglinger, M., Bertmar, C., Day, S., Borsodi, C., Herkes, G., Krause, M. (2016). Rapid access point of care clinic for transient ischemic attacks and minor strokes. Journal of Clinical Neuroscience, 23, 106-110. [More Information]
  • McGrath, R., Hocking, S., Priglinger, M., Day, S., Herkes, G., Krause, M., Fulcher, G. (2016). Rationale and design of Short-Term EXenatide therapy in Acute ischaemic Stroke (STEXAS): a randomised, open-label, parallel-group study. BMJ Open, 6(2), 1-7. [More Information]

2015

  • McGrath, R., Glastras, S., Hocking, S., Tjoeng, I., Krause, M., Fulcher, G. (2015). Central Functions of Glucagon-like Peptide-1: Roles in Energy Regulation and Neuroprotection. Journal of Steroids & Hormonal Science, 6(1), 1-8. [More Information]
  • Chinthapalli, K., Newey, A., Krause, M. (2015). Corticosteroid induced hyperosmolar hyperglycaemic state and hemiballismus. Oxford Medical Case Reports, 2015 (9), 320-322. [More Information]
  • Campbell, B., Mitchell, P., Kleinig, T., Dewey, H., Churilov, L., Yassi, N., Yan, B., Dowling, R., Parsons, M., Krause, M., Priglinger, M., et al (2015). Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection. New England Journal of Medicine, 372(11), 1009-1018. [More Information]

2014

  • Campbell, B., Mitchell, P., Yan, B., Parsons, M., Christensen, S., Churilov, L., Dowling, R., Dewey, H., Brooks, M., Miteff, F., Krause, M., et al (2014). A multicenter, randomized, controlled study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deï¬�cits with Intra-Arterial therapy (EXTEND-IA). International Journal of Stroke, 9(1), 126-132. [More Information]
  • Adam, R., Priglinger, M., Harrington, T., Gottlieb, D., Krause, M. (2014). An Unusual Cause of Cerebellar Hemorrhage in a Young Patient: Essential Thrombocythemia. Journal of Stroke and Cerebrovascular Diseases, 23(5), e373-e374. [More Information]
  • Phu, A., Xu, Z., Brakoulias, V., Mahant, N., Fung, V., De Moore, G., Martin, A., Starcevic, V., Krause, M. (2014). Effect of impulse control disorders on disability and quality of life in Parkinson's disease patients. Journal of Clinical Neuroscience, 21(1), 63-66. [More Information]

2013

  • Griffiths, D., Newey, A., Faulder, K., Steinfort, B., Krause, M. (2013). Thrombosis of a Developmental Venous Anomaly Causing Venous Infarction and Pontine Hemorrhage. Journal of Stroke and Cerebrovascular Diseases, 22(8), e653-655. [More Information]

2012

  • Ma, H., Parsons, M., Christensen, S., Campbell, B., Churilov, L., Connelly, A., Yan, B., Bladin, C., Phan, T., Barber, A., Krause, M., et al (2012). A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND). International Journal of Stroke, 7(1), 74-80. [More Information]
  • Krause, M., Mahant, N., Kotschet, K., Fung, V., Vagg, D., Wong, C., Morris, J. (2012). Dysexecutive behaviour following deep brain lesions - A different type of disconnection syndrome? Cortex, 48(1), 97-119. [More Information]
  • Volkmann, J., Wolters, A., Kupsch, A., Muller, J., Kuhn, A., Schneider, G., Poewe, W., Hering, S., Eisner, W., Muller, J., Krause, M., et al (2012). Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial. The Lancet Neurology, 11(12), 1029-1038. [More Information]

2011

  • Sandercock, P., Lindley, R., Wardlaw, J., Dennis, M., Innes, K., Cohen, G., Whiteley, W., Perry, D., Soosay, V., Buchanan, D., et al (2011). Update on the third international stroke trial (IST- 3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited. Trials, 12(252), 1-9. [More Information]

2010

  • Daniels, C., Krack, P., Volkmann, J., Pinsker, M., Krause, M., Tronnier, V., Kloss, M., Schnitzler, A., Wojtecki, L., Bötzel, K., et al (2010). Risk factors for executive dysfunction after subthalamic nucleus stimulation in Parkinson's disease. Movement Disorders, 25(11), 1583-1589. [More Information]

2008

  • Witt, K., Daniels, C., Reiff, J., Krack, P., Volkmann, J., Pinsker, M., Krause, M., Tronnier, V., Schnitzler, A., Hilker, R., et al (2008). Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study. The Lancet Neurology, 7(7), 605-614. [More Information]
  • Mueller, J., Skogseid, I., Benecke, R., Volkmann, J., Kupsch, A., Trottenberg, T., Poewe, W., Schnitzler, A., Krause, M., Brentrup, A., et al (2008). Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial. Movement Disorders, 23(1), 131-134. [More Information]

2007

  • Szabo, K., Hirsch, J., Krause, M., Ende, G., Henn, F., Sartorius, A., Gass, A. (2007). Diffusion weighted MRI in the early phase after electroconvulsive therapy. Neurological Research, 29(3), 256-259. [More Information]
  • Henninger, N., Wang, Q., Okun, J., Schwab, S., Krause, M. (2007). Nitrous oxide promotes hyperhomocysteinemia in levodopa treated rats. Parkinsonism and Related Disorders, 13(8), 524-527. [More Information]

2006

  • Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J., Schafer, H., Bötzel, K., Daniels, C., Deutschlander, A., Dillmann, U., Krause, M., et al (2006). A randomized trial of deep-brain stimulation for Parkinson's disease. New England Journal of Medicine, 355(9), 896-908. [More Information]
  • Lubik, S., Fogel, W., Tronnier, V., Krause, M., König, J., Jost, W. (2006). Gait analysis in patients with advanced Parkinson disease: different or additive effects on gait induced by levodopa and chronic STN stimulation. Journal of Neural Transmission, 113(2), 163-173. [More Information]
  • Krause, M., Fogel, W., Tronnier, V., Pohle, S., Hörtnagel, K., Thyen, U., Volkmann, J. (2006). Long-term benefit to pallidal deep brain stimulation in a case of dystonia secondary to pantothenate kinase-associated neurodegeneration. Movement Disorders, 21(12), 2255-2257. [More Information]

2004

  • Krause, M., Fogel, W., Mayer, P., Kloss, M., Tronnier, V. (2004). Chronic inhibition of the subthalamic nucleus in Parkinson's disease. Journal of the Neurological Sciences, 219(1-2), 119-124. [More Information]
  • Schroeder, U., Kuehler, A., Hennenlotter, A., Haslinger, B., Tronnier, V., Krause, M., Pfister, R., Sprengelmeyer, R., Lange, K., Ceballos-Baumann, A. (2004). Facial expression recognition and subthalamic nucleus stimulation. Journal of Neurology, Neurosurgery and Psychiatry, 75(4), 648-650. [More Information]
  • Krause, M., Fogel, W., Kloss, M., Rasche, D., Volkmann, J., Tronnier, V. (2004). Pallidal stimulation for dystonia. Neurosurgery, 55(6), 1361-1368. [More Information]

2003

  • Veltkamp, R., Krause, M., Schranz, C., Meinck, H. (2003). Progressive arm weakness and tonic hand spasm from multifocal motor neuropathy in the brachial plexus. Muscle and Nerve, 28(2), 242-245. [More Information]
  • Schroeder, U., Kuehler, A., Lange, K., Haslinger, B., Tronnier, V., Krause, M., Pfister, R., Boecker, H., Ceballos-Baumann, A. (2003). Subthalamic nucleus stimulation affects a frontotemporal network: a PET study. Annals of Neurology, 54(4), 445-450. [More Information]

Selected Grants

2017

  • Short-Term EXenatide therapy in Acute ischaemic Stroke (STEXAS) Study, McGrath R, Fulcher G, Hocking S, Krause M, National Stroke Foundation/Research Grant

2009

  • Impulse control disorders and quality of life in Parkinsons Disease, Krause M, Nepean Medical Research Foundation/Project Grant