People_
Dr Mary Kavurma
Conjoint Associate Professor
Group Leader, Vascular Complications Group
Heart Research Institute
Group Leader, Vascular Complications Group
Heart Research Institute
Phone
+61 (02) 8208 8900
Dr. Mary Kavurma is Conjoint Associate Professor at the University of Sydney. She is also Group Leader of the Vascular Complications Group and Associate Director of Research and Education at the Heart Research Institute. Mary received her PhD in 2003 from the Centre for Vascular Research, and in 2004 moved to the UK, Cambridge University an NHMRC CJ Martin Fellow, returning back in 2007. During her time back in Sydney, she established her independent research, joining the Heart Research Institute as Head of the Vascular Complications Group in 2013. Mary’s research interests are focused on understanding fundamental mechanisms in molecular and cellular biology leading to intimal thickening, atherosclerosis and its complications. She has held numerous Fellowships (NHMRC, HF and UNSW) and Project grants (NHMRC, HF). Mary has an active interest in promoting medical research to the lay community. Her achievements in scientific research, communication and community engagement were acknowledged with a Young Tall Poppy Science Award.
Associate Professor Kavurma’s experience and most significant contributions are in cell biology of atherosclerosis and cardiovascular disease (CVD) which can result in heart attack, stroke, and gangrene, and are leading causes of death and disability worldwide. The balance between vascular cell proliferation and death is an influential factor linking pathological changes in blood vessels and the progression of CVD. Associate Professor Kavurma’s research, particularly in the last 15 years has revolutionised our understanding of the molecules that control excessive cell growth, death, differentiation, and inflammation in the vessel wall.
Physiology of Disease
Atherosclerosis and cardiovascular disease
Obesity, Diabetes and Cardiovascular Disease
| Project title | Research student |
|---|---|
| Identify the source(s) of hydrogen peroxide for cis-WOOH formation in the microvascular endothelium. | Millard PHIPHATPHOL |
Publications
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Journals
- Liu, X., Huang, Y., Liu, D., Jiang, Y., Zhao, M., Chung, L., Han, X., Zhao, Y., Chen, J., Coleman, P., Ting, K., Tran, C., Su, Y., Don, A., Vadas, M., Gorrell, M., Murray, M., Kavurma, M., McCaughan, G., Gamble, J., Qi, Y., et al (2024). Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Journal of Translational Medicine, 22(1), 43. [More Information]
- Bate, K., Genetzakis, E., Vescovi, J., Gray, M., Celermajer, D., McGuire, H., Grieve, S., Vernon, S., Cartland, S., Yang, J., Kavurma, M., Figtree, G. (2024). Vascular Cytokines and Atherosclerosis: Differential Serum Levels of TRAIL, IL-18, and OPG in Obstructive Coronary Artery Disease. Biomolecules, 14, 1119. [More Information]
- Kavurma, M., Aitken, S., Boccanfuso, L., Cutmore, C., Passam, F., Patel, S., Hennessy, A., Loa, J., Figtree, G., Golledge, J. (2023). A hidden problem: peripheral artery disease in women. European Heart Journal - Quality of Care and Clinical Outcomes, 9(4), 342-350. [More Information]
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2024
- Liu, X., Huang, Y., Liu, D., Jiang, Y., Zhao, M., Chung, L., Han, X., Zhao, Y., Chen, J., Coleman, P., Ting, K., Tran, C., Su, Y., Don, A., Vadas, M., Gorrell, M., Murray, M., Kavurma, M., McCaughan, G., Gamble, J., Qi, Y., et al (2024). Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Journal of Translational Medicine, 22(1), 43. [More Information]
- Bate, K., Genetzakis, E., Vescovi, J., Gray, M., Celermajer, D., McGuire, H., Grieve, S., Vernon, S., Cartland, S., Yang, J., Kavurma, M., Figtree, G. (2024). Vascular Cytokines and Atherosclerosis: Differential Serum Levels of TRAIL, IL-18, and OPG in Obstructive Coronary Artery Disease. Biomolecules, 14, 1119. [More Information]
2023
- Kavurma, M., Aitken, S., Boccanfuso, L., Cutmore, C., Passam, F., Patel, S., Hennessy, A., Loa, J., Figtree, G., Golledge, J. (2023). A hidden problem: peripheral artery disease in women. European Heart Journal - Quality of Care and Clinical Outcomes, 9(4), 342-350. [More Information]
- Ghorbanpour, S., Richards, C., Pienaar, D., Sesperez, K., Aboulkheyr Es, H., Nikolic, V., Karadzov Orlic, N., Mikovic, Z., Stefanovic, M., Cakic, Z., et al (2023). A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia. Cellular and Molecular Life Sciences, 80(2). [More Information]
- Kelland, E., Patil, M., Patel, S., Cartland, S., Kavurma, M. (2023). The Prognostic, Diagnostic, and Therapeutic Potential of TRAIL Signalling in Cardiovascular Diseases. International Journal of Molecular Sciences, 24(7). [More Information]
2022
- Kavurma, M., Bursill, C., Stanley, C., Passam, F., Cartland, S., Patel, S., Loa, J., Figtree, G., Golledge, J., Aitken, S., et al (2022). Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease. Frontiers in Cardovascular Medicine, 9. [More Information]
2021
- Bubb, K., Ravindran, D., Cartland, S., Finemore, M., Clayton, Z., Tsang, M., Tang, O., Kavurma, M., Patel, S., Figtree, G. (2021). beta (3) Adrenergic Receptor Stimulation Promotes Reperfusion in Ischemic Limbs in a Murine Diabetic Model. Frontiers in Pharmacology, 12, 666334. [More Information]
- Vaidya, K., Tucker, B., Kurup, R., Khandkar, C., Pandzic, E., Barraclough, J., Machet, J., Misra, A., Kavurma, M., Martinez, G., Patel, S., et al (2021). Colchicine inhibits neutrophil extracellular trap formation in patients with acute coronary syndrome after percutaneous coronary intervention. Journal of the American Heart Association, 10(1), 1-13. [More Information]
- Di Bartolo, B., Cartland, S., Genner, S., Manuneedhi Cholan, P., Vellozzi, M., Rye, K., Kavurma, M. (2021). HDL Improves Cholesterol and Glucose Homeostasis and Reduces Atherosclerosis in Diabetes-Associated Atherosclerosis. Journal of Diabetes Research, 2021, 6668506. [More Information]
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2020
- Cartland, S., Tamer, N., Patil, M., Di Bartolo, B., Kavurma, M. (2020). A "Western Diet" promotes symptoms of hepatic steatosis in spontaneously hypertensive rats. International Journal of Experimental Pathology: mechanisms and models of disease, 101(5), 152-161. [More Information]
- Patil, M., Cartland, S., Kavurma, M. (2020). TRAIL signals, extracellular matrix and vessel remodelling. Vascular Biology, 2(1), R73-R84. [More Information]
- Cartland, S., Lin, R., Genner, S., Patil, M., Martinez, G., Barraclough, J., Gloss, B., Misra, A., Patel, S., Kavurma, M. (2020). Vascular transcriptome landscape of Trail−/− mice: Implications and therapeutic strategies for diabetic vascular disease. The FASEB Journal, 34(7), 9547-9562. [More Information]
2019
- Liu, G., Bursill, C., Cartland, S., Anwer, A., Parker, L., Zhang, K., Feng, S., He, M., Inglis, D., Kavurma, M., et al (2019). A Nanoparticle-Based Affinity Sensor that Identifies and Selects Highly Cytokine-Secreting Cells. iScience, 20, 137-147. [More Information]
- Ravindran, D., Cartland, S., Bursill, C., Kavurma, M. (2019). Broad-spectrum chemokine inhibition blocks inflammation-induced angiogenesis, but preserves ischemia-driven angiogenesis. The FASEB Journal, 33(12), 13423-13434. [More Information]
- Tucker, B., Kurup, R., Barraclough, J., Henriquez, R., Cartland, S., Arnott, C., Misra, A., Martinez, G., Kavurma, M., Patel, S. (2019). Colchicine as a Novel Therapy for Suppressing Chemokine Production in Patients With an Acute Coronary Syndrome: A Pilot Study. Clinical Therapeutics, 41(10), 2172-2181. [More Information]
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2018
- Manuneedhi Cholan, P., Cartland, S., Dang, L., Rayner, B., Patel, S., Thomas, S., Kavurma, M. (2018). TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro. Free Radical Biology and Medicine, 126, 341-349. [More Information]
2017
- Manuneedhi Cholan, P., Cartland, S., Kavurma, M. (2017). NADPH oxidases, angiogenesis, and peripheral artery disease. Antioxidants, 6(3), 1-14. [More Information]
- Cartland, S., Harith, H., Genner, S., Dang, L., Cogger, V., Vellozzi, M., Di Bartolo, B., Thomas, S., Adams, L., Kavurma, M. (2017). Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice. Scientific Reports, 7(1), 1-12. [More Information]
- Kavurma, M., Rayner, K., Karunakaran, D. (2017). The walking dead: macrophage inflammation and death in atherosclerosis. Current Opinion in Lipidology, 28(2), 91-98. [More Information]
2016
- Cartland, S., Genner, S., Zahoor, A., Kavurma, M. (2016). Comparative evaluation of trail, FGF-2 and VEGF-A-Induced angiogenesis in vitro and in vivo. International Journal of Molecular Sciences, 17(12), 1-11. [More Information]
- Harith, H., Di Bartolo, B., Cartland, S., Genner, S., Kavurma, M. (2016). Insulin promotes vascular smooth muscle cell proliferation and apoptosis via differential regulation of tumor necrosis factor-related apoptosis-inducing ligand. Journal of Diabetes, 8(4), 568-578. [More Information]
2015
- Di Bartolo, B., Cartland, S., Prado-Lourenco, L., Griffith, T., Gentile, C., Ravindran, J., Azahri, N., Thai, T., Yeung, A., Thomas, S., Kavurma, M. (2015). Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Angiogenesis and Ischemia-Induced Neovascularization Via NADPH Oxidase 4 (NOX4) and Nitric Oxide-Dependent Mechanisms. Journal of the American Heart Association, 4(11), 1-17. [More Information]
2014
- Di Bartolo, B., Kavurma, M. (2014). Regulation and function of Rankl in arterial calcification. Current Pharmaceutical Design, 20(37), 5853-5861. [More Information]
- Samaras, K., Morris, M., Lord, R., Kavurma, M. (2014). The effect of bariatric surgery on serum TRAIL and osteoprotegerin levels in obesity complicated by glucose disorders. e - SPEN Journal: the European e-journal of clinical nutrition and metabolism, 9(6), e210-e214. [More Information]
- Cartland, S., Erlich, J., Kavurma, M. (2014). TRAIL deficiency contributes to diabetic nephropathy in fat-fed ApoE -/- mice. PloS One, 9(3), 1-8. [More Information]
2013
- Di Bartolo, B., Cartland, S., Harith, H., Bobryshev, Y., Schoppet, M., Kavurma, M. (2013). TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL. PloS One, 8(9), e74211. [More Information]
2012
- Azahri, N., Di Bartolo, B., Khachigian, L., Kavurma, M. (2012). Sp1, acetylated histone-3 and p300 regulate TRAIL transcription: mechanisms of PDGF-BB-mediated VSMC proliferation and migration. Journal Of Cellular Biochemistry, 113(8), 2597-2606. [More Information]
2011
- Di Bartolo, B., Chan, J., Bennett, M., Cartland, S., Bao, B., Tuch, B., Kavurma, M. (2011). TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe ( -/- ) mice. Diabetologia, 54(12), 3157-3167. [More Information]
Selected Grants
2023
- On the TRAIL of peripheral artery disease, Kavurma M, Cartland S, Stanley C, Tumanov S, National Health and Medical Research Council (NHMRC)/Ideas Grant
2019
- Endothelial Cell-Pericyte Crosstalk: Novel interactions for generating stable and functional blood vessels in ischaemia, Kavurma M, Cartland S, Patel S, Robinson D, Griffith T, National Health and Medical Research Council (NHMRC)/Ideas Grant
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