2024

• Scherer, N., Yerbury, J., Francois, M., Chung, R., Morsch, M., Maurel, C., Graus, M., Mcalary, L., Richter, G., Radford, R., et al (2024). RNA-binding properties orchestrate TDP-43 homeostasis through condensate formation in vivo. Nucleic Acids Research, 52(9), 5301-5319. [More Information]

2023

• Weng, M., Hu, H., Graus, M., Tan, D., Gao, Y., Ren, S., Ho, D., Langer, J., Holzner, M., Huang, Y., Francois, M., et al (2023). An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming. Science Advances, 9(34), eadh2501. [More Information]
• Chiang, I., Graus, M., Kirschnick, N., Davidson, T., Luu, W., Harwood, R., Jiang, K., Li, B., Wong, Y., Moustaqil, M., Francois, M., et al (2023). The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. EMBO Journal, 42(5). [More Information]
• Voges, H., Foster, S., Reynolds, L., Parker, B., Devilée, L., Quaife-Ryan, G., Fortuna, P., Mathieson, E., Fitzsimmons, R., Lor, M., Francois, M., Needham, E., Chong, J., et al (2023). Vascular cells improve functionality of human cardiac organoids. Cell Reports, 42(5). [More Information]

2022

• Seebauer, C., Graus, M., Huang, L., McCann, A., Wylie-Sears, J., Fontaine, F., Karnezis, T., Zurakowski, D., Staffa, S., Meunier, F., Francois, M., et al (2022). Non–beta blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma. Journal of Clinical Investigation, 132(3). [More Information]
• Chau, T., Baek, S., Coxam, B., Skoczylas, R., Rondon-Galeano, M., Bower, N., Wainwright, E., Stacker, S., Cooper, H., Koopman, P., et al (2022). Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice. Developmental Dynamics, 251(2), 336-349. [More Information]

2021

• McCann, A., Lou, J., Moustaqil, M., Graus, M., Blum, A., Fontaine, F., Liu, H., Luu, W., Rudolffi-Soto, P., Koopman, P., Francois, M., et al (2021). A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity. Nucleic Acids Research, 49(19), 10931-10955. [More Information]
• Jiang, K., Pichol-Thievend, C., Neufeld, Z., Francois, M. (2021). Assessment of heterogeneity in collective endothelial cell behavior with multicolor clonal cell tracking to predict arteriovenous remodeling. Cell Reports, 36(3), 109395. [More Information]
• Francois, M., Oszmiana, A., Harvey, N. (2021). When form meets function: The cells and signals that shape the lymphatic vasculature during development. Development, 148(11), 167098. [More Information]

2020

• Wong, E., Zheng, D., Tan, S., Bower, N., Garside, V., Vanwalleghem, G., Gaiti, F., Scott, E., Hogan, B., Kikuchi, K., Francois, M., et al (2020). Deep conservation of the enhancer regulatory code in animals. Science, 370(6517), 1-10. [More Information]
• Villani, R., Sim, S., Roy, E., Wainwright, B., Francois, M., Khosrotehrani, K. (2020). Ectopic expression of SOX18 in Basal cell carcinoma negatively regulates tumour progression. Journal of Dermatological Science, 98(3), 179-185. [More Information]
• Rondon-Galeano, M., Skoczylas, R., Bower, N., Simons, C., Gordon, E., Francois, M., Koltowska, K., Hogan, B. (2020). MAFB modulates the maturation of lymphatic vascular networks in mice. Developmental Dynamics, 249(10), 1201-1216. [More Information]
• Francios, M., Donovan, P., Fontaine, F. (2020). Modulating transcription factor activity: Interfering with protein-protein interaction networks. Seminars in Cell & Developmental Biology, 99, 12-19. [More Information]
• Gramolelli, S., Elbasani, E., Tuohinto, K., Nurminen, V., Günther, T., Kallinen, R., Kaijalainen, S., Diaz, R., Grundhoff, A., Haglund, C., Francois, M., et al (2020). Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production. Cancer Research, 80(15), 3116-3129. [More Information]

2019

• Donovan, P., Patel, J., Dight, J., Wong, H., Sim, S., Murigneux, V., Francios, M., Khosrotehrani, K. (2019). Endovascular progenitors infiltrate melanomas and differentiate towards a variety of vascular beds promoting tumor metastasis. Nature Communications, 10(1), 18. [More Information]
• Overman, J., Fontaine, F., Sears, J., Moustaqil, M., Huang, L., Meurer, M., Chiang, I., Lesieur, E., Patel, J., Zuegg, J., et al (2019). R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. eLife, 8, e43026. [More Information]
• Kinnear, S., Salamonsen, L., Francios, M., Harley, V., Evans, J. (2019). Uterine SOX17: a key player in human endometrial receptivity and embryo implantation. Scientific Reports, 9(1), 15495. [More Information]
• Vivien, C., Pichol-Thievend, C., Sim, C., Smith, J., Bower, N., Hogan, B., Hudson, J., Francios, M., Porrello, E. (2019). Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context. n p j Regenerative Medicine, 4(1), 18. [More Information]

2018

• Pichol-Thievend, C., Betterman, K., Liu, X., Ma, W., Skoczylas, R., Lesieur, E., Bos, F., Schulte, D., Schulte-Merker, S., Hogan, B., et al (2018). A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development. Development, 145(10), dev160184. [More Information]
• Fontaine, F., Goodall, S., Prokop, J., Howard, C., Moustaqil, M., Kumble, S., Rasicci, D., Osborne, G., Gambin, Y., Sierecki, E., et al (2018). Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach. mAbs, 10(4), 596-606. [More Information]
• Moustaqil, M., Fontaine, F., Overman, J., McCann, A., Bailey, T., Soto, P., Bhumkar, A., Giles, N., Hunter, D., Gambin, Y., et al (2018). Homodimerization regulates an endothelial specific signature of the SOX18 transcription factor. Nucleic Acids Research, 46(21), 11381-11395. [More Information]

2017

• Villani, R., Hodgson, S., Legrand, J., Greaney, J., Wong, H., Pichol-Thievend, C., Adolphe, C., Wainwight, B., Francios, M., Khosrotehrani, K. (2017). Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development, 144(10), 1887-1895. [More Information]
• Patel, J., Seppanen, E., Rodero, M., Wong, H., Donovan, P., Neufeld, Z., Fisk, N., Francios, M., Khosrotehrani, K. (2017). Functional Definition of Progenitors Versus Mature Endothelial Cells Reveals Key SoxF-Dependent Differentiation Process. Circulation, 135(8), 786-805. [More Information]
• Bower, N., Koltowska, K., Pichol-Thievend, C., Virshup, I., Paterson, S., Lagendijk, A., Wang, W., Lindsey, B., Bent, S., Baek, S., et al (2017). Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish. Nature Neuroscience, 20(6), 774-783. [More Information]
• Overman, J., Fontaine, F., Moustaqil, M., Mittal, D., Sierecki, E., Sacilotto, N., Zuegg, J., Robertson, A., Holmes, K., Salim, A., et al (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6, e21221. [More Information]
• Fontaine, F., Overman, J., Moustaqil, M., Mamidyala, S., Salim, A., Narasimhan, K., Prokoph, N., Robertson, A., Lua, L., Alexandrov, K., et al (2017). Small-Molecule Inhibitors of the SOX18 Transcription Factor. Cell Chemical Biology, 24(3), 346-359. [More Information]
• Chiang, I., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K., Lagendijk, A., Overman, J., D’Angelo, D., Omini, A., Hermkens, D., et al (2017). SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144(14), 2629-2639. [More Information]
• De Angelis, J., Lagendijk, A., Chen, H., Tromp, A., Bower, N., Tunny, K., Brooks, A., Bakkers, J., Francios, M., Yap, A., et al (2017). Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover. Developmental Cell, 40(2), 123-136. [More Information]

2016

• Legrand, J., Roy, E., Ellis, J., Francios, M., Brooks, A., Khosrotehrani, K. (2016). STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction. Journal of Investigative Dermatology, 136(9), 1781-1791. [More Information]
• Klaus, M., Prokoph, N., Girbig, M., Wang, X., Huang, Y., Srivastava, Y., Hou, L., Narasimhan, K., Kolatkar, P., Francios, M., et al (2016). Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction. Nucleic Acids Research, 44(8), 3922-3935. [More Information]

2015

• Moon, H., Ruelcke, J., Choi, E., Sharpe, L., Nassar, Z., Bielefeldt-Ohmann, H., Parat, M., Shah, A., Francios, M., Inder, K., et al (2015). Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1. Oncotarget, 6(10), 7438-7453. [More Information]
• Moalem, S., Brouillard, P., Kuypers, D., Legius, E., Harvey, E., Taylor, G., Francios, M., Vikkula, M., Chitayat, D. (2015). Hypotrichosis-lymphedema-telangiectasia-renal defect associated with a truncating mutation in the SOX18 gene. Clinical Genetics, 87(4), 378-382. [More Information]
• Koltowska, K., Paterson, S., Bower, N., Baillie, G., Lagendijk, A., Astin, J., Chen, H., Francios, M., Crosier, P., Taft, R., et al (2015). mafba is a downstream transcriptional effector of vegfc signaling essential for embryonic lymphangiogenesis in zebrafish. Genes and Development, 29(15), 1618-1630. [More Information]
• Nassar, Z., Hill, M., Parton, R., Francios, M., Parat, M. (2015). Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis. Oncoscience, 2(7), 635-645. [More Information]
• Fontaine, F., Overman, J., Francios, M. (2015). Pharmacological manipulation of transcription factor protein-protein interactions: Opportunities and obstacles. Cell Regeneration, 4(1), 4:2. [More Information]
• Koltowska, K., Lagendijk, A., Pichol-Thievend, C., Fischer, J., Francios, M., Ober, E., Yap, A., Hogan, B. (2015). Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. Cell Reports, 13(9), 1828-1841. [More Information]

2014

• Kartopawiro, J., Bower, N., Karnezis, T., Kazenwadel, J., Betterman, K., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., et al (2014). Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics, 23(5). [More Information]
• Bowles, J., Secker, G., Nguyen, C., Kazenwadel, J., Truong, V., Frampton, E., Curtis, C., Skoczylas, R., Davidson, T., Miura, N., et al (2014). Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Developmental Biology, 386(1), 25-33. [More Information]
• Pichol-Thievend, C., Hogan, B., Francios, M. (2014). Lymphatic vascular specification and its modulation during embryonic development. Microvascular research, 96, 3-9. [More Information]
• Coxam, B., Sabine, A., Bower, N., Smith, K., Pichol-Thievend, C., Skoczylas, R., Astin, J., Frampton, E., Jaquet, M., Crosier, P., et al (2014). Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development. Cell Reports, 7(3), 623-633. [More Information]
• Aspelund, A., Tammela, T., Antila, S., Nurmi, H., Leppänen, V., Zarkada, G., Stanczuk, L., Francios, M., Mäkinen, T., Saharinen, P., et al (2014). The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. Journal of Clinical Investigation, 124(9), 3975-3986. [More Information]
• Duong, T., Koltowska, K., Pichol-Thievend, C., Le Guen, L., Fontaine, F., Smith, K., Truong, V., Skoczylas, R., Stacker, S., Achen, M., et al (2014). VEGFD regulates blood vascular development by modulating SOX18 activity. Blood, 123(7), 1102-1112. [More Information]

2013

• Nassar, Z., Moon, H., Duong, T., Neo, L., Hill, M., Francios, M., Parton, R., Parat, M. (2013). PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis. Oncotarget, 4(10), 1844-1855. [More Information]
• Cermenati, S., Moleri, S., Neyt, C., Bresciani, E., Carra, S., Grassini, D., Omini, A., Goi, M., Cotelli, F., Francios, M., et al (2013). Sox18 genetically interacts With VegfC to regulate lymphangiogenesis in zebrafish. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(6), 1238-1247. [More Information]