People_

Dr Megan Finch-Edmondson

Senior Research Fellow, Cerebral Palsy Alliance Research Institute
Adjunct Senior Lecturer, Sydney Medical School / Children's Hospital at Westmead
Faculty of Medicine and Health (FMH)

Email

megan.finch-edmondson@sydney.edu.au

Details

Member of the Brain and Mind Centre

Biographical details

Dr Megan Finch-Edmondson currently holds the role of Senior Stem Cell Research Fellow and Regeneration Program Lead at the Cerebral Palsy Alliance Research Institute, and is an affiliate of The University of Sydney in the Sydney Medical School,Children's Hospital at Westmead, Faculty of Medicine and Health. Megan’s background is in cell biology, with a particular focus on signalling pathways and their contribution to stem cell biology and cancer. In her current role, Megan leads a team working to develop clinical trials for the prevention and treatment of cerebral palsy focused on a variety of cellular therapies. She considers herself an emerging leader in the field of stem cell research and clinical trials, and has a particular passion for consumer and community engagement.

Themes

Reproductive, Maternal and Child Health, Neurosciences and Mental Health

Keywords

Regeneration medicine/Tissue engineering, Stem cells, Cerebral Palsy, Paediatrics and Child Health

Approaches

Cellular/Molecular, Child, Clinical Trials

Publications

By Type

Expand all

Book Chapters

Passaniti, A., Brusgard, J., Qiao, Y., Sudol, M., Finch-Edmondson, M. (2017). Roles of RUNX in Hippo Pathway Signaling. In Y Groner, Y Ito, P Liu, J C Neil, N A Speck, & A van Wijnen (Eds.), RUNX Proteins in Development and Cancer, (pp. 435-448). Singapore: Springer Nature Singapore. [More Information]

Journals

Smith, M., Finch-Edmondson, M., Miller, S., Webb, A., Fahey, M., Jenkin, G., Paton, M., McDonald, C. (2023). Acceptability of neural stem cell therapy for cerebral palsy: survey of the Australian cerebral palsy community. Stem Cell Research & Therapy, 14(1). [More Information]
Smith, M., Penny, T., Pham, Y., Sutherland, A., Jenkin, G., Fahey, M., Paton, M., Finch-Edmondson, M., Miller, S., McDonald, C. (2023). Neuroprotective Action of Tacrolimus before and after Onset of Neonatal Hypoxic–Ischaemic Brain Injury in Rats. Cells, 12(22). [More Information]
Finch-Edmondson, M., Paton, M., Honan, I., Galea, C., Webb, A., Novak, I., Badawi, N., Trivedi, A. (2023). Proportion of Infant Neurodevelopment Trials Reporting a Null Finding: A Systematic Review. Pediatrics, 151(2). [More Information]
Finch-Edmondson, M., Paton, M., Honan, I., Karlsson, P., Stephenson, C., Chiu, D., Reedman, S., Griffin, A., Morgan, C., Novak, I. (2022). Are We Getting It Right? A Scoping Review of Outcomes Reported in Cell Therapy Clinical Studies for Cerebral Palsy. Journal of Clinical Medicine, 11(24). [More Information]
Paton, M., Finch-Edmondson, M., Galea, C., Garrity, N., Fahey, M., Novak, I. (2022). Education can improve clinician confidence in information sharing and willingness to refer to stem cell clinical trials for cerebral palsy. Journal of investigative medicine, 70(1), 85-91. [More Information]
Roy, B., Walker, K., Morgan, C., Finch-Edmondson, M., Galea, C., Badawi, N., Novak, I. (2022). Epidemiology and pathogenesis of stroke in preterm infants: A systematic review. Journal of Neonatal and Perinatal Medicine, 15(1), 11-18. [More Information]
Honan, I., Finch-Edmondson, M., Imms, C., Novak, I., Hogan, A., Clough, S., Bonyhady, B., McIntyre, S., Elliott, C., Wong, S., Badawi, N., et al (2022). Is the search for cerebral palsy ‘cures’ a reasonable and appropriate goal in the 2020s? Developmental Medicine and Child Neurology, 64(1), 49-55. [More Information]
te Velde, A., Morgan, C., Finch-Edmondson, M., McNamara, L., McNamara, M., Paton, M., Stanton, E., Webb, A., Badawi, N., Novak, I. (2022). Neurodevelopmental Therapy for Cerebral Palsy: A Meta-analysis. Pediatrics, 149(6). [More Information]
Paton, M., Finch-Edmondson, M., Dale, R., Fahey, M., Nold-Petry, C., Nold, M., Griffin, A., Novak, I. (2022). Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review. Journal of Clinical Medicine, 11(24). [More Information]
Paton, M., Wall, D., Elwood, N., Chiang, K., Cowie, G., Novak, I., Finch-Edmondson, M. (2022). Safety of allogeneic umbilical cord blood infusions for the treatment of neurological conditions: a systematic review of clinical studies. Cytotherapy, 24(1), 2-9. [More Information]
Paton, M., Finch-Edmondson, M., Fahey, M., London, J., Badawi, N., Novak, I. (2021). Fifteen years of human research using stem cells for cerebral palsy: A review of the research landscape. Journal of Paediatrics and Child Health, 57(2), 295-296. [More Information]
Passman, A., Strauss, R., Mcspadden, S., Finch, M., Andrewartha, N., Woo, K., Diepeveen, L., Zhao, W., Fernández-Irigoyen, J., Santamaría, E., et al (2021). Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model. Cancers, 13(19), 4935. [More Information]
Zhu, B., Mitheera, V., Finch-Edmondson, M., Lee, Y., Wan, Y., Sudol, M., Dasgupta, R. (2021). MiR-582-5p is a tumor suppressor microRNA targeting the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer. Cancers, 13(4), 1-21. [More Information]
Smith, M., Paton, M., Fahey, M., Jenkin, G., Miller, S., Finch-Edmondson, M., McDonald, C. (2021). Neural stem cell treatment for perinatal brain injury: A systematic review and meta-analysis of preclinical studies. Stem Cells Translational Medicine, 10(12), 1621-1636. [More Information]
Paton, M., Cowie, G., Galea, C., Badawi, N., White, R., Novak, I., Finch-Edmondson, M. (2021). Positive perception of stem cells for neurological conditions: Results from an Australian public forum. Regenerative Medicine, 16(4), 347-357. [More Information]
Lee, Y., Finch-Edmondson, M., Cognart, H., Zhu, B., Song, H., Chuan, L., Sudol, M. (2020). Common and unique transcription signatures of YAP and TAZ in gastric cancer cells. Cancers, 12(12), 1-15. [More Information]
Strauss, R., Audsley, K., Passman, A., van Vuuren, J., Finch, M., Callus, B., Yeoh, G. (2020). Loss of ARF/INK4A promotes liver progenitor cell transformation toward tumorigenicity supporting their role in hepatocarcinogenesis. Gene Expression, 20(1), 39-52. [More Information]
Novak, I., Morgan, C., Fahey, M., Finch-Edmondson, M., Galea, C., Hines, A., Langdon, K., McNamara, M., Paton, M., Popat, H., Khamis, A., Stanton, E., Finemore, O., Tricks, A., te Velde, A., Badawi, N., et al (2020). State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy. Current Neurology and Neuroscience Reports, 20(2), 3. [More Information]
Badawi, N., Honan, I., Finch-Edmondson, M., Hogan, A., Fitzgerald, J., Imms, C. (2020). The Australian & New Zealand Cerebral Palsy Strategy. Developmental Medicine and Child Neurology, 62(8), 885. [More Information]
Finch-Edmondson, M., Morgan, C., Hunt, R., Novak, I. (2019). Emergent Prophylactic, Reparative and Restorative Brain Interventions for Infants Born Preterm With Cerebral Palsy. Frontiers in Physiology, 10, 1-26. [More Information]
Callus, B., Finch-Edmondson, M., Fletcher, S., Wilton, S. (2019). YAPping about and not forgetting TAZ. FEBS Letters, 593(3), 253-276. [More Information]
Ferraiuolo, M., Pulito, C., Finch-Edmondson, M., Korita, E., Maidecchi, A., Donzelli, S., Muti, P., Serra, M., Sudol, M., Strano, S., et al (2018). Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines. Cancer Letters, 433, 18-32. [More Information]
Verma, A., Jing-Song, F., Finch-Edmondson, M., Velazquez-Campoy, A., Balasegaran, S., Sudol, M., Sivaraman, J. (2018). Biophysical studies and NMR structure of YAP2 WW domain-LATS1 PPxY motif complexes reveal the basis of their interaction. Oncotarget, 9(8), 8068-8080. [More Information]
Singh, A., Galland, R., Finch-Edmondson, M., Grenci, G., Sibarita, J., Studer, V., Viasnoff, V., Saunders, T. (2017). 3D Protein Dynamics in the Cell Nucleus. Biophysical Journal, 112(1), 133-142. [More Information]
Qiao, Y., Chen, J., Lim, Y., Finch-Edmondson, M., Seshachalam, V., Qin, L., Jiang, T., Low, B., Singh, H., Lim, C., et al (2017). YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis. Cell Reports, 19(8), 1495-1502. [More Information]
Passman, A., Low, J., London, R., Tirnitz-Parker, J., Miyajima, A., Tanaka, M., Strick-Marchand, H., Darlington, G., Finch-Edmondson, M., Ochsner, S., et al (2016). A Transcriptomic Signature of Mouse Liver Progenitor Cells. Stem Cells International, 2016, 5702873. [More Information]
Goodall, K., Finch, M., Van Vuuren, J., Yeoh, G., Gentle, I., Vince, J., Ekert, P., Vaux, D., Callus, B. (2016). Cycloheximide can induce bax/bak dependent myeloid cell death independently of multiple BH3-only proteins. PloS One, 11(11), e0164003. [More Information]
Finch-Edmondson, M., Sudol, M. (2016). Framework to function: Mechanosensitive regulators of gene transcription. Cellular and Molecular Biology Letters, 21(1), 28. [More Information]
Woo, K., Stewart, S., Kong, G., Finch, M., Dwyer, B., Yeung, S., Abraham, L., Kampmann, S., Diepeveen, L., Passman, A., et al (2016). Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib. European Journal of Medicinal Chemistry, 120, 275-283. [More Information]
Finch, M., Strauss, R., Clayton, J., Yeoh, G., Callus, B. (2016). Splice variant insertions in the C-terminus impairs YAP's transactivation domain. Biochemistry and Biophysics Reports, 6, 24-31. [More Information]
Passman, A., Strauss, R., Mcspadden, S., Finch, M., Woo, K., Diepeveen, L., London, R., Callus, B., Yeoh, G. (2015). A modified choline-Deficient, ethionine-Supplemented diet reduces morbidity and retains a liver progenitor cell response in mice. Disease Models & Mechanisms, 8(12), 1635-1641. [More Information]
Finch, M., Passman, A., Strauss, R., Yeoh, G., Callus, B. (2015). Sub-cellular localisation studies may spuriously detect the yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function. PloS One, 10(2), 114813. [More Information]
Finch, M., Strauss, R., Passman, A., Sudol, M., Yeoh, G., Callus, B. (2015). TAZ protein accumulation is negatively regulated by YAP abundance in mammalian cells. Journal of Biological Chemistry, 290(46), 27928-27938. [More Information]
Finch, M., Marquardt, J., Yeoh, G., Callus, B. (2014). Regulation of microRNAs and their role in liver development, regeneration and disease. International Journal of Biochemistry and Cell Biology, 54, 288-303. [More Information]

show 31 more

By Year

Expand all

2023

Smith, M., Finch-Edmondson, M., Miller, S., Webb, A., Fahey, M., Jenkin, G., Paton, M., McDonald, C. (2023). Acceptability of neural stem cell therapy for cerebral palsy: survey of the Australian cerebral palsy community. Stem Cell Research & Therapy, 14(1). [More Information]
Smith, M., Penny, T., Pham, Y., Sutherland, A., Jenkin, G., Fahey, M., Paton, M., Finch-Edmondson, M., Miller, S., McDonald, C. (2023). Neuroprotective Action of Tacrolimus before and after Onset of Neonatal Hypoxic–Ischaemic Brain Injury in Rats. Cells, 12(22). [More Information]
Finch-Edmondson, M., Paton, M., Honan, I., Galea, C., Webb, A., Novak, I., Badawi, N., Trivedi, A. (2023). Proportion of Infant Neurodevelopment Trials Reporting a Null Finding: A Systematic Review. Pediatrics, 151(2). [More Information]

2022

Finch-Edmondson, M., Paton, M., Honan, I., Karlsson, P., Stephenson, C., Chiu, D., Reedman, S., Griffin, A., Morgan, C., Novak, I. (2022). Are We Getting It Right? A Scoping Review of Outcomes Reported in Cell Therapy Clinical Studies for Cerebral Palsy. Journal of Clinical Medicine, 11(24). [More Information]
Paton, M., Finch-Edmondson, M., Galea, C., Garrity, N., Fahey, M., Novak, I. (2022). Education can improve clinician confidence in information sharing and willingness to refer to stem cell clinical trials for cerebral palsy. Journal of investigative medicine, 70(1), 85-91. [More Information]
Roy, B., Walker, K., Morgan, C., Finch-Edmondson, M., Galea, C., Badawi, N., Novak, I. (2022). Epidemiology and pathogenesis of stroke in preterm infants: A systematic review. Journal of Neonatal and Perinatal Medicine, 15(1), 11-18. [More Information]
Honan, I., Finch-Edmondson, M., Imms, C., Novak, I., Hogan, A., Clough, S., Bonyhady, B., McIntyre, S., Elliott, C., Wong, S., Badawi, N., et al (2022). Is the search for cerebral palsy ‘cures’ a reasonable and appropriate goal in the 2020s? Developmental Medicine and Child Neurology, 64(1), 49-55. [More Information]
te Velde, A., Morgan, C., Finch-Edmondson, M., McNamara, L., McNamara, M., Paton, M., Stanton, E., Webb, A., Badawi, N., Novak, I. (2022). Neurodevelopmental Therapy for Cerebral Palsy: A Meta-analysis. Pediatrics, 149(6). [More Information]
Paton, M., Finch-Edmondson, M., Dale, R., Fahey, M., Nold-Petry, C., Nold, M., Griffin, A., Novak, I. (2022). Persistent Inflammation in Cerebral Palsy: Pathogenic Mediator or Comorbidity? A Scoping Review. Journal of Clinical Medicine, 11(24). [More Information]
Paton, M., Wall, D., Elwood, N., Chiang, K., Cowie, G., Novak, I., Finch-Edmondson, M. (2022). Safety of allogeneic umbilical cord blood infusions for the treatment of neurological conditions: a systematic review of clinical studies. Cytotherapy, 24(1), 2-9. [More Information]

show 4 more

2021

Paton, M., Finch-Edmondson, M., Fahey, M., London, J., Badawi, N., Novak, I. (2021). Fifteen years of human research using stem cells for cerebral palsy: A review of the research landscape. Journal of Paediatrics and Child Health, 57(2), 295-296. [More Information]
Passman, A., Strauss, R., Mcspadden, S., Finch, M., Andrewartha, N., Woo, K., Diepeveen, L., Zhao, W., Fernández-Irigoyen, J., Santamaría, E., et al (2021). Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model. Cancers, 13(19), 4935. [More Information]
Zhu, B., Mitheera, V., Finch-Edmondson, M., Lee, Y., Wan, Y., Sudol, M., Dasgupta, R. (2021). MiR-582-5p is a tumor suppressor microRNA targeting the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer. Cancers, 13(4), 1-21. [More Information]
Smith, M., Paton, M., Fahey, M., Jenkin, G., Miller, S., Finch-Edmondson, M., McDonald, C. (2021). Neural stem cell treatment for perinatal brain injury: A systematic review and meta-analysis of preclinical studies. Stem Cells Translational Medicine, 10(12), 1621-1636. [More Information]
Paton, M., Cowie, G., Galea, C., Badawi, N., White, R., Novak, I., Finch-Edmondson, M. (2021). Positive perception of stem cells for neurological conditions: Results from an Australian public forum. Regenerative Medicine, 16(4), 347-357. [More Information]

show 2 more

2020

Lee, Y., Finch-Edmondson, M., Cognart, H., Zhu, B., Song, H., Chuan, L., Sudol, M. (2020). Common and unique transcription signatures of YAP and TAZ in gastric cancer cells. Cancers, 12(12), 1-15. [More Information]
Strauss, R., Audsley, K., Passman, A., van Vuuren, J., Finch, M., Callus, B., Yeoh, G. (2020). Loss of ARF/INK4A promotes liver progenitor cell transformation toward tumorigenicity supporting their role in hepatocarcinogenesis. Gene Expression, 20(1), 39-52. [More Information]
Novak, I., Morgan, C., Fahey, M., Finch-Edmondson, M., Galea, C., Hines, A., Langdon, K., McNamara, M., Paton, M., Popat, H., Khamis, A., Stanton, E., Finemore, O., Tricks, A., te Velde, A., Badawi, N., et al (2020). State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy. Current Neurology and Neuroscience Reports, 20(2), 3. [More Information]
Badawi, N., Honan, I., Finch-Edmondson, M., Hogan, A., Fitzgerald, J., Imms, C. (2020). The Australian & New Zealand Cerebral Palsy Strategy. Developmental Medicine and Child Neurology, 62(8), 885. [More Information]

show 1 more

2019

Finch-Edmondson, M., Morgan, C., Hunt, R., Novak, I. (2019). Emergent Prophylactic, Reparative and Restorative Brain Interventions for Infants Born Preterm With Cerebral Palsy. Frontiers in Physiology, 10, 1-26. [More Information]
Callus, B., Finch-Edmondson, M., Fletcher, S., Wilton, S. (2019). YAPping about and not forgetting TAZ. FEBS Letters, 593(3), 253-276. [More Information]

2018

Ferraiuolo, M., Pulito, C., Finch-Edmondson, M., Korita, E., Maidecchi, A., Donzelli, S., Muti, P., Serra, M., Sudol, M., Strano, S., et al (2018). Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines. Cancer Letters, 433, 18-32. [More Information]
Verma, A., Jing-Song, F., Finch-Edmondson, M., Velazquez-Campoy, A., Balasegaran, S., Sudol, M., Sivaraman, J. (2018). Biophysical studies and NMR structure of YAP2 WW domain-LATS1 PPxY motif complexes reveal the basis of their interaction. Oncotarget, 9(8), 8068-8080. [More Information]

2017

Singh, A., Galland, R., Finch-Edmondson, M., Grenci, G., Sibarita, J., Studer, V., Viasnoff, V., Saunders, T. (2017). 3D Protein Dynamics in the Cell Nucleus. Biophysical Journal, 112(1), 133-142. [More Information]
Passaniti, A., Brusgard, J., Qiao, Y., Sudol, M., Finch-Edmondson, M. (2017). Roles of RUNX in Hippo Pathway Signaling. In Y Groner, Y Ito, P Liu, J C Neil, N A Speck, & A van Wijnen (Eds.), RUNX Proteins in Development and Cancer, (pp. 435-448). Singapore: Springer Nature Singapore. [More Information]
Qiao, Y., Chen, J., Lim, Y., Finch-Edmondson, M., Seshachalam, V., Qin, L., Jiang, T., Low, B., Singh, H., Lim, C., et al (2017). YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis. Cell Reports, 19(8), 1495-1502. [More Information]

2016

Passman, A., Low, J., London, R., Tirnitz-Parker, J., Miyajima, A., Tanaka, M., Strick-Marchand, H., Darlington, G., Finch-Edmondson, M., Ochsner, S., et al (2016). A Transcriptomic Signature of Mouse Liver Progenitor Cells. Stem Cells International, 2016, 5702873. [More Information]
Goodall, K., Finch, M., Van Vuuren, J., Yeoh, G., Gentle, I., Vince, J., Ekert, P., Vaux, D., Callus, B. (2016). Cycloheximide can induce bax/bak dependent myeloid cell death independently of multiple BH3-only proteins. PloS One, 11(11), e0164003. [More Information]
Finch-Edmondson, M., Sudol, M. (2016). Framework to function: Mechanosensitive regulators of gene transcription. Cellular and Molecular Biology Letters, 21(1), 28. [More Information]
Woo, K., Stewart, S., Kong, G., Finch, M., Dwyer, B., Yeung, S., Abraham, L., Kampmann, S., Diepeveen, L., Passman, A., et al (2016). Identification of a thalidomide derivative that selectively targets tumorigenic liver progenitor cells and comparing its effects with lenalidomide and sorafenib. European Journal of Medicinal Chemistry, 120, 275-283. [More Information]
Finch, M., Strauss, R., Clayton, J., Yeoh, G., Callus, B. (2016). Splice variant insertions in the C-terminus impairs YAP's transactivation domain. Biochemistry and Biophysics Reports, 6, 24-31. [More Information]

show 2 more

2015

Passman, A., Strauss, R., Mcspadden, S., Finch, M., Woo, K., Diepeveen, L., London, R., Callus, B., Yeoh, G. (2015). A modified choline-Deficient, ethionine-Supplemented diet reduces morbidity and retains a liver progenitor cell response in mice. Disease Models & Mechanisms, 8(12), 1635-1641. [More Information]
Finch, M., Passman, A., Strauss, R., Yeoh, G., Callus, B. (2015). Sub-cellular localisation studies may spuriously detect the yes-associated protein, YAP, in nucleoli leading to potentially invalid conclusions of its function. PloS One, 10(2), 114813. [More Information]
Finch, M., Strauss, R., Passman, A., Sudol, M., Yeoh, G., Callus, B. (2015). TAZ protein accumulation is negatively regulated by YAP abundance in mammalian cells. Journal of Biological Chemistry, 290(46), 27928-27938. [More Information]

2014

Finch, M., Marquardt, J., Yeoh, G., Callus, B. (2014). Regulation of microRNAs and their role in liver development, regeneration and disease. International Journal of Biochemistry and Cell Biology, 54, 288-303. [More Information]

Selected Grants

2020