People_
Dr Monokesh Sen
Research Focused Academic
School of Medical Sciences
Faculty of Medicine and Health (FMH)
School of Medical Sciences
Faculty of Medicine and Health (FMH)
Phone
0478774956
Details
Member of The Centre for Drug Discovery Innovation
Member of the Charles Perkins Centre
Websites
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I have two main research interests:
A): Remyelination in Multiple Sclerosis
In Multiple Sclerosis (MS), inadequate remyelination leads to progressive demyelination and permanent disability. This lack of remyelination is associated with inadequate phagocytosis by microglia and astrocytes in the site of demyelination. My interest includes how remyelination can be accelerated by the effective modulation of glial cells.
B): Blood-based biomarker of Multiple Sclerosis
Cerebrospinal fluid (CSF) is the primary sample of interest in biomarker discovery in people with MS. However, CSF collection is invasive which is associated with pain and distress. In addition, it is not practical of collecting CSF in regular and long-term monitoring of MS patients. My interest is to find an easily accessible, but central nervous system protein/lipid-rich, blood biomarker as an alternative to CSF for routine research and clinical use.
- Neuroanatomy
- Neurobiology
- Neuroimmunology
- Neuroscience
- Proteomics
- Identification of serum extracellular vesicles (EVs) protein biomarkers of multiple sclerosis
- Member of the ECR Neuroscience Theme(August 2024-)
- Charles Perkins Centre-Early and Middle Career Researcher committee member for Communication Role (May 2023-)
- Americas Committee for Treatment and Research in Multiple Sclerosis-2023
- The American Association of Immunologist-2022
- European Academy of Allergy and Clinical Immunology-2020
- Neuroimmunology Australia-2019
- Australasian Neuroscience Society-2018
- Society for Neuroscience-2017
- Australian Bioinformatics and Computational Biology Society-2017
- Charles Perkins Centre Early to Mid-Career Researcher Professional Development Award - 2023
- Cellular and Molecular Advances in Neurodegeneration Conference Postdoctoral fellow poster presentationAward-2023
- Top reviewer recognition: Journal of Neuroimmunology-2023
- Drug Discovery Initiative ECR Travel Award - 2023
- MSMilan2023 – 9thECTRIMS- ACTRIMS MeetingTravel award - 2023
- The American Association of Immunologists Careers in Immunology Fellowship - 2022 (September 2022-August 2023)
- Americas Committee for Treatment in Multiple Sclerosis (ACTRIMS) Young Scientist Summit Travel Award - 2022
- Australasian Neuroscience Society Student Travel Award - 2018
- Western Sydney University-International postgraduate research scholarship (IPRS), Australia - 2014
- Best performing graduate student scholarship,Directorate of Secondary and Higher Education, Bangladesh - 2010
- Academic excellence scholarship, Islamic University, Kushtia, Bangladesh - 2009
Australasian Neuroscience Society Student Travel Award-2018
Western Sydney University-International postgraduate research scholarship (IPRS), Australia- 2014
Best performing graduate student scholarship,Directorate of Secondary and Higher Education, Bangladesh-2010
Academic excellence scholarship, Islamic University, Kushtia, Bangladesh-2009 Neuroscience Society Student Travel Award-2018
Western Sydney University-International postgraduate research scholarship (IPRS), Australia- 2014
Best performing graduate student scholarship,Directorate of Secondary and Higher Education, Bangladesh-2010
Academic excellence scholarship, Islamic University, Kushtia, Bangladesh-2009
Neurosciences and Mental Health, Healthy Ageing
| Project title | Research student |
|---|---|
| Investigating the molecular mechanism of TREM2-mediated microglial myelin debris clearance in central nervous system demyelination | Yifei ZHOU |
Publications
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Journals
- Summers, B., Broome, S., Pang, T., Mundell, H., Belic, N., Tom, N., Ng, M., Yap, M., Sen, M., Sedaghat, S., et al (2024). A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease. International Journal of Tryptophan Research, 17, 11786469241248287-11786469241248287. [More Information]
- Barman, S., Sen, M., Mahns, D., Wu, M., Malladi, C. (2024). Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc. Journal of Oncology, , 9925970-21. [More Information]
- Teo, J., Marian, O., Spiteri, A., Nicholson, M., Song, H., Khor, J., McEwen, H., Ge, A., Sen, M., Piccio, L., King, N., Don, A., et al (2023). Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. GLIA, 71(4), 1120-1141. [More Information]
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2024
- Summers, B., Broome, S., Pang, T., Mundell, H., Belic, N., Tom, N., Ng, M., Yap, M., Sen, M., Sedaghat, S., et al (2024). A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease. International Journal of Tryptophan Research, 17, 11786469241248287-11786469241248287. [More Information]
- Barman, S., Sen, M., Mahns, D., Wu, M., Malladi, C. (2024). Molecular Insights into the Breast and Prostate Cancer Cells in Response to the Change of Extracellular Zinc. Journal of Oncology, , 9925970-21. [More Information]
2023
- Teo, J., Marian, O., Spiteri, A., Nicholson, M., Song, H., Khor, J., McEwen, H., Ge, A., Sen, M., Piccio, L., King, N., Don, A., et al (2023). Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. GLIA, 71(4), 1120-1141. [More Information]
- Liang, H., Sen, M., Gyengesi, E., Munch, G., Ullah, F. (2023). Editorial: Pharmacological approaches towards the resolution of neuroinflammation and neurodegeneration. Frontiers in Pharmacology, 13, 1132126. [More Information]
- Sen, M., Ge, A., Liao, E., Gard, H., Ni, D., Macia, L., Piccio, L. (2023). Impact of a high fibre diet on immune cells and the multiple sclerosis animal model. Journal of Immunology, 210(Suppl 1). [More Information]
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2022
- Asgarov, R., Sen, M., Mikhael, M., Karl, T., Gyengesi, E., Mahns, D., Malladi, C., Muench, G. (2022). Characterisation of the Mouse Cerebellar Proteome in the GFAP‑IL6 Model of Chronic Neuroinflammation. Cerebellum, 21, 404-424. [More Information]
- Almuslehi, M., Sen, M., Shortland, P., Mahns, D., Coorssen, J. (2022). Histological and Top-Down Proteomic Analyses of the Visual Pathway in the Cuprizone Demyelination Model. Journal of Molecular Neuroscience, 72(6), 1374-1401. [More Information]
- Ullah, F., Gamage, R., Sen, M., Gyengesi, E. (2022). The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation. Neurochemical Research, 47(4), 813-824. [More Information]
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2021
- Sen, M., Hossain, M. (2021). Oligodendrocyte-Specific Mechanisms of Myelin Thinning: Implications for Neurodegenerative Diseases. Frontiers in Neuroscience, 15, 663053. [More Information]
- Sen, M., Almuslehi, M., Shortland, P., Mahns, D., Coorssen, J. (2021). Proteomics of Multiple Sclerosis: Inherent Issues in Defining the Pathoetiology and Identifying (Early) Biomarkers. International Journal of Molecular Sciences, 22(14), 7377. [More Information]
2020
- Sen, M., Almuslehi, M., Coorssen, J., Mahns, D., Shortland, P. (2020). Behavioural and histological changes in cuprizone-fed mice. Brain, Behavior, and Immunity, 87, 508-523. [More Information]
- Almuslehi, M., Sen, M., Shortland, P., Mahns, D., Coorssen, J. (2020). CD8 T-cell Recruitment Into the Central Nervous System of Cuprizone-Fed Mice: Relevance to Modeling the Etiology of Multiple Sclerosis. Frontiers in Cellular Neuroscience, 14, 43. [More Information]
- Sen, M., Almuslehi, M., Shortland, P., Coorssen, J., Mahns, D. (2020). Revisiting the Pathoetiology of Multiple Sclerosis: Has the Tail Been Wagging the Mouse. Frontiers in Immunology, 11, 572186. [More Information]
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2019
- Sen, M., Mahns, D., Coorssen, J., Shortland, P. (2019). Behavioural phenotypes in the cuprizone model of central nervous system demyelination. Neuroscience and Biobehavioral Reviews, 107, 23-27.
- Sen, M., Almuslehi, M., Gyengesi, E., Myers, S., Shortland, P., Mahns, D., Coorssen, J. (2019). Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis. Cells, 8(11), 1314. [More Information]
2014
- Sen, M., Nasrin, S., Rahman, S., Jamal, A. (2014). In vitro callus induction and plantlet regeneration of Achyranthes aspera L., a high value medicinal plant. Asian Pacific journal of tropical biomedicine, 4(1), 40-46. [More Information]
2013
- Dash, B., Sen, M., Alam, K., Hossain, K., Islam, R., Banu, N., Rahman, S., Jamal, M. (2013). Antibacterial activity of Nymphaea nouchali (Burm. f) flower. Annals of Clinical Microbiology and Antimicrobials, 12(1), 27-27. [More Information]
Selected Grants
2023
- Professional Development Award 2023, Sen M, Charles Perkins Centre/Early to Mid-Career Researcher Professional Development
- Identification of serum extracellular vesicles (EVs) protein biomarkers of multiple sclerosis, Sen M, Charles Perkins Centre/Early-Mid Career Researcher Seed Funding Grant
- Lipid biomarkers in cerebrospinal fluid and blood samples in people with multiple sclerosis, Piccio L, Don A, Hardy T, Sen M, Brain Australia/Research Grant
VOLUNTEERING
- X-Lab demonstrators (LifeLab Sydney): Demonstrating and providing hands-on training on DNA extraction and gel electrophoresis to high-school students, 11th and 17th November 2022, Charles Perkins Centre, The University of Sydney.
- Speed Researcher Meet: Speaking with high-school students to encourage in research – 14th July 2022, Charles Perkins Centre, The University of Sydney.
EDITORIAL ROLE
- Topic co-editor: Frontiers in Cellular Neuroscience (August 2023-); Topic: Mitochondrial Dysfunction and Therapeutics for Neurodegeneration and Aging (https://www.frontiersin.org/research-topics/58859/mitochondrial-dysfunction-and-therapeutics-for-neurodegeneration-and-aging#overview).
- Guest Editor: Pharmaceuticals (Oct 2022-); Topic:Microglia and Astrocytes as Drug Targets (https://www.mdpi.com/journal/pharmaceuticals/special_issues/6L0A0357G1)
- Guest Associate Editor: Frontiers in Pharmacology (Jan-Oct 2022); Topic: https://www.frontiersin.org/research-topics/31298/pharmacological-approaches-towards-the-resolution-of-neuroinflammation-and-neurodegeneration#overview
- Review editor: Frontiers in Neuroscience (Neurodegeneration section).
In the media
- LifeLab Sydney demonstration:https://vimeo.com/790626088/096170761f
- https://intranet.sydney.edu.au/medicine-and-health/news-events/news/2023/02/fmh-wins-20-february.html