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Associate Professor Patrick Bertolino

Associate Professor
Medicine, Central Clinical SchoolFaculty and Head of the Liver Immunology Program at the Centenary Institute

Phone

+61 2 9565 6186

Fax

+61 2 9565 6100

Email

patrick.bertolino@sydney.edu.au

Websites

Research of the Liver Immunology Group

Centenary Institute profile

Biographical details

Patrick Bertolino leads the Liver Immunology Group and has been a Faculty member at the Centenary Institute since 2011. He is considered one of the leading experts in Liver Immunology internationally, and is acknowledged as the leader in this field in Australia, where he drives the main group working in this new and expanding discipline.

Patrick Bertolino has worked in the same field for the last 20 years in excellent research institutes, and has been trained by first class immunologists (ENS-Lyon, France: Chantal Rabourdin-Combe; WEHI: Jacques Miller; Centenary Institute: Barbara Fazekas de St Groth). During this time, he has developed unique transgenic mouse models and has acquired a leading international reputation in liver immunology. This reputation derives from original landmark pioneering papers that have transformed the field, and are now part of current paradigms. These include the first demonstration of naïve CD8 T cell activation in the liver, the first evidence of direct interaction between circulating T cells and hepatocytes, the role of intrahepatic T cell activation in tolerance, and the discovery that liver-activated T cells are deleted in the lysosomes of hepatocytes.

Patrick Bertolino has had consistent success in obtaining major international and national project grants as CIA, demonstrating independence and leadership. He has held continuous NHMRC funding since 2000: 2 Program Grants (PI 2005-9, CI 2010-4), and 6 Project grants (5 CIA, 1 CIB). He has also obtained highly competitive international funding (Roche Solid Organ Transplantation Research Foundation).

Research interests

The liver immunology group is studying the unique relationship between the liver and the immune system. Livers dampen down immunity to such an extent that they can be transplanted without rejection in some cases. Livers may not only be tolerated, but may also prevent the rejection of other organ grafts from the same donor, a process known as immune tolerance.

Although this tolerance effect leads to better outcomes in transplantation, it can be detrimental during infections such as hepatitis B, hepatitis C and malaria, that use this liver property to persist, leading to chronic infection.

Having already shown that the liver, like the lymph nodes, can activate T cells, a key cell of the immune system, the group is investigating how the liver induces immune tolerance and how immunity can be enhanced in this organ. This knowledge could not only lead to better treatments in transplantation, but also to more effective prevention and treatment of chronic liver disease.

The laboratory is also examining people undergoing liver transplantation for disease related to hepatitis C infection, which recurs post-transplant, and can cause recurrent disease. By studying the immune response to the hepatitis C virus in this group of patients, the researchers hope to gain important insights into factors that could improve treatment outcomes.

This group’s research is also providing some important clues to improve the success of human gene therapy.

Teaching and supervision

University of Sydney: Immunology lectures (3^rd year Immunology) Since 1998.

Current projects

Our studies are currently focused on four main aspects:

Understanding which parameters regulate the fate of T cells activated by liver cells.

Investigating the mechanisms responsible for the clearance of recently activated T cells by hepatocytes.

Exploring solid organ transplantation in mice to understand the factors leading to spontaneous liver graft acceptance and, investigating mechanisms determined in these models in humans receiving liver transplants.

Understanding immune responses to the hepatitis C virus in individuals undergoing liver transplantation for hepatitis C virus-related liver disease, and how these responses influence the clinical outcome of liver transplantation in this population.

Associations

Since 2000: member of the Australian Society of Immunology (ASI)

Since 2000: member of Gastroenterological Society of Australia (GESA)

Awards and honours

2010 NHMRC Senior Research Felllowship

2009 Centenary Institute for the student highest IF paper (Student: Lauren Holz)

1999 ASI 2001 Kevin Lafferty Memorial Prize for Autoimmunity.

1997 University of SydneyU2000 fellow

Themes

Cancer, Infection and Immunological Conditions, Healthy Ageing

Keywords

Autoimmunity, Hepatitis, Hepatology, Immune tolerance, Immunology

Approaches

Animal Models, Cellular/Molecular, Immunology

PhD and master's project opportunities

Unravelling mechanisms determining the balance between tolerance and immunity in the liver

Publications

By Type

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Book Chapters

Bowen, D., Bertolino, P. (2014). Immune Responses to the Hepatitis C Virus. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 476-486). New York: Springer Science+Business Media. [More Information]
Bertolino, P., Bowen, D. (2014). Primary T-Cell Activation in Liver. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 899-905). New York: Springer Science+Business Media. [More Information]
Le Couteur, D., Warren, A., Cogger, V., Bertolino, P. (2014). Ultrastructure of the Liver Sinusoid. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 1235-1240). New York: Springer Science+Business Media. [More Information]
Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.
Bertolino, P., McCaughan, G., Bowen, D. (2008). Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In Emilio Jirillo (Eds.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications, (pp. 39-70). United States: Springer. [More Information]
Bertolino, P., Bowen, D., Zen, M., McCaughan, G. (2005). Autoimmune hepatitis in transgenic mouse models: what lessons can be learnt? In H. P. Dienes, U. Leuschner, A. W. Lohse, M. P. Manns (Eds.), Autoimmune Liver Disease: Proceedings of the Falk Symposium No. 142, (pp. 60-72). The Netherlands: Springer.

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Journals

Adams, R., Wixey, J., Nayler, S., Hill, G., Furlan, S., Zeiser, R., MacDonald, K., Carter-Cusack, D., Llanes, G., Hunter, C., Bertolino, P., et al (2024). CSF1R inhibition promotes neuroinflammation and behavioral deficits during graft-versus-host disease in mice. Blood, 143(10), 912-929. [More Information]
Ganley, M., Holz, L., Minnell, J., de Menezes, M., Burn, O., Poa, K., Draper, S., English, K., Chan, S., Anderson, R., Bertolino, P., et al (2023). mRNA vaccine against malaria tailored for liver-resident memory T cells. Nature Immunology, 24(9), 1487-1498. [More Information]
Chen, J., Zhao, Y., Zhang, F., Li, J., Boland, J., Cheng, N., Liu, K., Tiffen, J., Bertolino, P., Bowen, D., Lisowski, L., Alexander, I., Vadas, M., Gamble, J., McCaughan, G., et al (2022). Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7. Cellular and Molecular Life Sciences, 79(8). [More Information]
Valencia-Hernandez, A., Ng, W., Ghazanfari, N., Ghilas, S., de Menezes, M., Holz, L., Huang, C., English, K., Naung, M., Tan, P., Bowen, D., Bertolino, P., et al (2020). A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice. Cell Host and Microbe, 27(6), 950-962.e7. [More Information]
Holz, L., Chua, Y., de Menezes, M., Anderson, R., Draper, S., Compton, B., Chan, S., Mathew, J., Li, J., Kedzierski, L., Bertolino, P., Bowen, D., et al (2020). Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria. Science Immunology, 5(48), eaaz8035. [More Information]
McCaughan, G., Bowen, D., Bertolino, P. (2020). Induction Phase of Spontaneous Liver Transplant Tolerance. Frontiers in Immunology, 11, 1908. [More Information]
Goodall, K., Nguyen, A., Matsumoto, A., McMullen, J., Eckle, S., Bertolino, P., Sullivan, L., Andrews, D. (2019). Multiple receptors converge on H2-Q10 to regulate NK and gamma delta T-cell development. Immunology and Cell Biology, 97(3), 326-339. [More Information]
Mekonnen, Z., Grubor-Bauk, B., English, K., Leung, P., Masavuli, M., Shrestha, A., Bertolino, P., Bowen, D., Lloyd, A., Gowans, E., et al (2019). Single-Dose Vaccination with a Hepatotropic Adeno-associated Virus Efficiently Localizes T Cell Immunity in the Liver with the Potential To Confer Rapid Protection against Hepatitis C Virus. Journal of Virology, 93(19), 1-19. [More Information]
Sheu, A., Chan, Y., Ferguson, A., Bakhtyari, M., Hawke, W., White, C., Chan, Y., Bertolino, P., Woon, H., Palendira, M., Sierro, F., et al (2018). A proinflammatory CD4+ T cell phenotype in gestational diabetes mellitus. Diabetologia, 61(7), 1633-1643. [More Information]
Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
Holz, L., Prier, J., Freestone, D., Steiner, T., English, K., Johnson, D., Mollard, V., Cozijnsen, A., Davey, G., Godfrey, D., Bertolino, P., et al (2018). CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver. Cell Reports, 25(1), 68-79. [More Information]
Paul-Heng, M., Leong, M., Cunningham, E., Bunker, D., Bremner, K., Wang, Z., Wang, C., Tay, S., McGuffog, C., Logan, G., Alexander, I., Hu, M., Alexander, S., Bertolino, P., Bowen, D., Bishop, A., Sharland, A., et al (2018). Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction. JCI Insight, 3(15), 1-19. [More Information]
Florido, M., Muflihah, H., Lin, L., Xia, Y., Sierro, F., Palendira, M., Feng, C., Bertolino, P., Stambas, J., Triccas, J., Britton, W. (2018). Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis. Mucosal Immunology, 11(6), 1743-1752. [More Information]
Sierro, F., Evrard, M., Rizzetto, S., Melino, M., Mitchell, A., Florido, M., Beattie, L., Walters, S., Tay, S., Lu, B., Roediger, B., Wong, Y., Warren, A., Ritchie, W., McGuffog, C., Weninger, W., Le Couteur, D., Britton, W., Saunders, B., McCaughan, G., Bowen, D., Bertolino, P., et al (2017). A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment. Immunity, 47(2), 374-388. [More Information]
Wang, X., Holz, L., Chowdhury, S., Cordoba, S., Evans, K., Gall, M., Vieira de Ribeiro, A., Zheng, Y., Levy, M., Yu, M., Yao, T., Polak, N., Jolly, C., Bertolino, P., McCaughan, G., Gorrell, M. (2017). The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury. Immunology and Cell Biology, 95(5), 443-453. [More Information]
Lovelace, M., Powter, E., Coleman, P., Zhao, Y., Parker, A., Chang, G., Lay, A., Hunter, J., McGrath, A., Jormakka, M., Bertolino, P., McCaughan, G., Vadas, M., Gamble, J., et al (2017). The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells. Molecular Biology of the Cell, 28(8), 1066-1078. [More Information]
McNamara, H., Cai, Y., Wagle, M., Sontani, Y., Roots, C., Miosge, L., O'Connor, J., Sutton, H., Ganusov, V., Bertolino, P. (2017). Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids. Science Immunology, 2(9), 1-21. [More Information]
Vo, M., Holz, L., Wong, Y., English, K., Benseler, V., McGuffog, C., Azuma, M., McCaughan, G., Bowen, D., Bertolino, P. (2016). Effector T cell function rather than survival determines extent and duration of hepatitis in mice. Journal of Hepatology, 64(6), 1327-1338. [More Information]
Fernandez-Ruiz, D., Ng, W., Holz, L., Ma, J., Zaid, A., Wong, Y., Lau, L., Mollard, V., Cozijnsen, A., Collins, N., Tay, S., Bowen, D., Bertolino, P., et al (2016). Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection. Immunity, 45(4), 889-902. [More Information]
Wong, Y., McCaughan, G., Bowen, D., Bertolino, P. (2016). The CD8 T-cell response during tolerance induction in liver transplantation. Clinical & Translational Immunology, 5(10), 1-12. [More Information]
Powter, E., Coleman, P., Tran, M., Lay, A., Bertolino, P., Parton, R., Vadas, M., Gamble, J. (2015). Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. Aging Cell, 14(1), 102-111. [More Information]
McCaughan, G., Bertolino, P., Bowen, D. (2015). Could the morning after liver transplant be immunologically interesting? Liver Transplantation, 21(9), 1120-1122. [More Information]
Wong, Y., Tay, S., McCaughan, G., Bowen, D., Bertolino, P. (2015). Immune outcomes in the liver: Is CD8 T cell fate determined by the environment? Journal of Hepatology, 63(4), 1005-1014. [More Information]
Guo, J., McQuillan, J., Yau, B., Tullo, G., Long, C., Bertolino, P., Roediger, B., Weninger, W., Taylor, G., Hunt, N., Ball, H., et al (2015). IRGM3 Contributes to Immunopathology and Is Required for Differentiation of Antigen-Specific Effector CD8 T Cells in Experimental Cerebral Malaria. Infection and Immunity, 83(4), 1406-1417. [More Information]
Bertolino, P., Bowen, D. (2015). Malaria and the liver: immunological hide-and-seek or subversion of immunity from within? Frontiers in Microbiology, 6(FEB), 1-15. [More Information]
Brockhausen, J., Tay, S., Grzelak, C., Bertolino, P., Bowen, D., d'Avigdor, W., Teoh, N., Pok, S., Shackel, N., Gamble, J., Vadas, M., et al (2015). miR-181a mediates TGF-Î²-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer. Liver International, 35(1), 240-253. [More Information]
Bolton, H., Zhu, E., Terry, A., Guy, T., Koh, W., Tan, S., Power, C., Bertolino, P., Lahl, K., Sparwasser, T., Shklovskaya, E., Fazekas de St Groth, B. (2015). Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. Journal of Clinical Investigation, 125(9), 3627-3641. [More Information]
Sierro, F., Tay, S., Warren, A., Le Couteur, D., McCaughan, G., Bowen, D., Bertolino, P. (2015). Suicidal Emperipolesis: A process leading to cell-in-cell structures, T cell clearance and immune homeostasis. Current Molecular Medicine, 15(9), 819-827. [More Information]
Le Couteur, D., Tay, S., Solon-Biet, S., Bertolino, P., McMahon, A., Cogger, V., Colakoglu, F., Warren, A., Holmes, A., Pichaud, N., Raubenheimer, D., Simpson, S., et al (2015). The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 70(12), 1499-1507. [More Information]
Tay, S., Wong, Y., McDonald, D., Wood, N., Roediger, B., Sierro, F., McGuffog, C., Alexander, I., Bishop, A., Gamble, J., Weninger, W., McCaughan, G., Bertolino, P., Bowen, D. (2014). Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2540-E2549. [More Information]
Tay, S., Wong, Y., Roediger, B., Sierro, F., Lu, B., McDonald, D., McGuffog, C., Meyer, N., Alexander, I., Parish, I., Weninger, W., Bishop, A., Gamble, J., McCaughan, G., Bertolino, P., Bowen, D., et al (2014). Intrahepatic activation of naive CD4+T cells by liver-resident phagocytic cells. Journal of Immunology, 193(5), 2087-2095. [More Information]
Tay, S., Lu, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A., Cowan, P., McCaughan, G., Dwyer, K., Bowen, D., et al (2013). Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation. Liver Transplantation, 19(11), 1224-1235. [More Information]
Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
McCaughan, G., Bowen, D., Bertolino, P. (2013). Operational tolerance in liver transplantation: Shall we predict or promote? Liver Transplantation, 19(9), 933-936. [More Information]
Chowdhury, S., Chen, Y., Yao, T., Ajami, K., Wang, X., Popov, Y., Schuppan, D., Bertolino, P., McCaughan, G., Yu, M., Gorrell, M. (2013). Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World Journal of Gastroenterology, 19(19), 2883-2893. [More Information]
Holz, L., Benseler, V., Vo, M., McGuffog, C., Van Rooijen, N., McCaughan, G., Bowen, D., Bertolino, P. (2012). Naive CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2(low) Bim(high) phenotype, poor CTL function and cell death. Journal of Hepatology, 57(4), 830-836. [More Information]
Bishop, A., Bertolino, P., Bowen, D., McCaughan, G. (2012). Tolerance in liver transplantation. Best Practice & Research: Clinical Gastroenterology, 26(1), 73-84. [More Information]
Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012). Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology, 57(2), 352-358. [More Information]
Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16735-16740. [More Information]
Benseler, V., Tay, S., Bowen, D., Bertolino, P. (2011). Role of the Hepatic Parenchyma in Liver Transplant Tolerance: a Paradigm Revisited. Digestive Diseases, 29(4), 391-401. [More Information]
Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]
Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
Viebahn, C., Benseler, V., Holz, L., Elsegood, C., Vo, M., Bertolino, P., Ganss, R., Yeoh, G. (2010). Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury. Journal of Hepatology, 53(3), 500-507. [More Information]
Holz, L., Bowen, D., Bertolino, P. (2010). Mechanisms of T cell death in the liver: to Bim or not to Bim? Digestive Diseases, 28(1), 14-24. [More Information]
McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
Dahlke, M., Hoogduijn, M., Eggenhofer, E., Popp, F., Renner, P., Slowik, P., Rosenauer, A., Piso, P., Bertolino, P., Schlitt, H., et al (2009). Toward MSC in Solid Organ Transplantation: 2008 Position Paper of the MISOT Study Group. Transplantation, 88, 614-619. [More Information]
Allen, K., Mifsud, N., Williamson, R., Bertolino, P., Hardikar, W. (2008). Cell-mediated rejection results in allograft loss after liver cell transplantation. Liver Transplantation, 14(5), 688-694. [More Information]
Bertolino, P. (2008). Impaired function of dendritic cells translocating the liver sinusoids: a veto effect contributing to intrahepatic tolerance? European Journal of Immunology, 38(4), 938-941. [More Information]
Bertolino, P. (2008). Interleukin-22, interleukin-17, and other cytokines: a wall is coming down. Hepatology, 47(1), 345-348. [More Information]
Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., D'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008). Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology, 135(3), 989-997. [More Information]
Holz, L., McCaughan, G., Benseler, V., Bertolino, P., Bowen, D. (2008). Liver tolerance and the manipulation of immune outcomes. Inflammation and Allergy: Drug Targets, 7(1), 6-18. [More Information]
Bertolino, P., Bowen, D., Benseler, V. (2007). T cells in the liver: there is life beyond the graveyard. Hepatology, 45(6), 1580-1582. [More Information]
Benseler, V., McCaughan, G., Schlitt, H., Bishop, A., Bowen, D., Bertolino, P. (2007). The liver: a special case in transplantation tolerance. Seminars in Liver Disease, 27(2), 194-213. [More Information]
Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]
Bertolino, P., Holz, L. (2007). Toll-like receptor-3 and the regulation of intrahepatic immunity: implications for interferon-alpha therapy. Hepatology, 45(1), 250-251. [More Information]
Wang, C., Cordoba, S., Bertolino, P., Alexander, S., Wu, M., Allen, R., McCaughan, G., Bishop, A. (2006). Examination of the immune mechanism of spontaneous tolerance of renal allografts in a mouse model. Immunology and Cell Biology, 84(1), A29-30.
Dahlke, M., Loi, R., Warren, A., Holz, L., Popp, F., Weiss, D., Piso, P., Bowen, D., McCaughan, G., Schlitt, H., Bertolino, P. (2006). Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology, 44(2), 334-341. [More Information]
Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]
Bertolino, P., Schrage, A., Bowen, D., Klugewitz, K., Ghani, S., Eulenburg, K., Holz, L., Hogg, N., McCaughan, G., Hamann, A. (2005). Early intrahepatic antigen-specific retention of naÃ¯ve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology, 42(5), 1063-1071. [More Information]
Cordoba, S., Wang, C., Li, J., Bertolino, P., McCaughan, G., Bishop, A. (2005). Examination of immune mechanisms in a mouse model of spontaneous renal allograft acceptance. Immunology and Cell Biology, 83(4 Supplement), A20-A21.
Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
Bowen, D., McCaughan, G., Bertolino, P. (2005). Intrahepatic immunity: a tale of two sites? Trends in Immunology, 26(10), 512-517. [More Information]
Sun, J., Tumurbaatar, B., Jia, J., Diao, H., Bodola, F., Lemon, S., Tang, W., Bowen, D., McCaughan, G., Bertolino, P., et al (2005). Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury. Journal of Virology, 79(16), 10730-10739. [More Information]
Holz, L., Benseler, V., Gengos, M., Newtown, R., McCaughan, G., Bertolino, P. (2005). Phenotype of CD8+ T cells activated in the liver. Tissue Antigens: immune response genetics, 66(5), 444 (Abstract 279)-444.
Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.
McCaughan, G., Bertolino, P., Bowen, D., Zen, M., Holz, L., Davis, T. (2004). The Site Of Primary T Cell Activation Is A Determinant Of The Balance Between Intrahepatic Tolerance And Immunity. Journal of Clinical Investigation, 114(5), 701-712. [More Information]
Demangel, C., Bertolino, P., Britton, W. (2002). Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. European Journal of Immunology, 32(4), 994-1002.
Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas de St Groth, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264. [More Information]
Greenhalgh, C., Bertolino, P., Asa, S., Metcalf, D., Corbin, J., Adams, T., Davey, H., Nicola, N., Hilton, D., Alexander, W. (2002). Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Molecular Endocrinology, 16(6), 1394-1406. [More Information]
Bertolino, P., McCaughan, G., Bowen, D. (2002). Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'. Immunology and Cell Biology, 80(1), 84-92. [More Information]
Bertolino, P., Bowen, D., McCaughan, G., Fazekas de St Groth, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.

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Conferences

Benseler, V., Holz, L., Schlitt, H., Brinkmann, V., McCaughan, G., Bertolino, P. (2006). FTY720 treatment leads to sequestration but not accumulation of antigen-specific CD8+ T cells activated in lymph nodes.

By Year

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2024

Adams, R., Wixey, J., Nayler, S., Hill, G., Furlan, S., Zeiser, R., MacDonald, K., Carter-Cusack, D., Llanes, G., Hunter, C., Bertolino, P., et al (2024). CSF1R inhibition promotes neuroinflammation and behavioral deficits during graft-versus-host disease in mice. Blood, 143(10), 912-929. [More Information]

2023

Ganley, M., Holz, L., Minnell, J., de Menezes, M., Burn, O., Poa, K., Draper, S., English, K., Chan, S., Anderson, R., Bertolino, P., et al (2023). mRNA vaccine against malaria tailored for liver-resident memory T cells. Nature Immunology, 24(9), 1487-1498. [More Information]

2022

Chen, J., Zhao, Y., Zhang, F., Li, J., Boland, J., Cheng, N., Liu, K., Tiffen, J., Bertolino, P., Bowen, D., Lisowski, L., Alexander, I., Vadas, M., Gamble, J., McCaughan, G., et al (2022). Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7. Cellular and Molecular Life Sciences, 79(8). [More Information]

2020

Valencia-Hernandez, A., Ng, W., Ghazanfari, N., Ghilas, S., de Menezes, M., Holz, L., Huang, C., English, K., Naung, M., Tan, P., Bowen, D., Bertolino, P., et al (2020). A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice. Cell Host and Microbe, 27(6), 950-962.e7. [More Information]
Holz, L., Chua, Y., de Menezes, M., Anderson, R., Draper, S., Compton, B., Chan, S., Mathew, J., Li, J., Kedzierski, L., Bertolino, P., Bowen, D., et al (2020). Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria. Science Immunology, 5(48), eaaz8035. [More Information]
McCaughan, G., Bowen, D., Bertolino, P. (2020). Induction Phase of Spontaneous Liver Transplant Tolerance. Frontiers in Immunology, 11, 1908. [More Information]

2019

Goodall, K., Nguyen, A., Matsumoto, A., McMullen, J., Eckle, S., Bertolino, P., Sullivan, L., Andrews, D. (2019). Multiple receptors converge on H2-Q10 to regulate NK and gamma delta T-cell development. Immunology and Cell Biology, 97(3), 326-339. [More Information]
Mekonnen, Z., Grubor-Bauk, B., English, K., Leung, P., Masavuli, M., Shrestha, A., Bertolino, P., Bowen, D., Lloyd, A., Gowans, E., et al (2019). Single-Dose Vaccination with a Hepatotropic Adeno-associated Virus Efficiently Localizes T Cell Immunity in the Liver with the Potential To Confer Rapid Protection against Hepatitis C Virus. Journal of Virology, 93(19), 1-19. [More Information]

2018

Sheu, A., Chan, Y., Ferguson, A., Bakhtyari, M., Hawke, W., White, C., Chan, Y., Bertolino, P., Woon, H., Palendira, M., Sierro, F., et al (2018). A proinflammatory CD4+ T cell phenotype in gestational diabetes mellitus. Diabetologia, 61(7), 1633-1643. [More Information]
Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
Holz, L., Prier, J., Freestone, D., Steiner, T., English, K., Johnson, D., Mollard, V., Cozijnsen, A., Davey, G., Godfrey, D., Bertolino, P., et al (2018). CD8+ T Cell Activation Leads to Constitutive Formation of Liver Tissue-Resident Memory T Cells that Seed a Large and Flexible Niche in the Liver. Cell Reports, 25(1), 68-79. [More Information]
Paul-Heng, M., Leong, M., Cunningham, E., Bunker, D., Bremner, K., Wang, Z., Wang, C., Tay, S., McGuffog, C., Logan, G., Alexander, I., Hu, M., Alexander, S., Bertolino, P., Bowen, D., Bishop, A., Sharland, A., et al (2018). Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction. JCI Insight, 3(15), 1-19. [More Information]
Florido, M., Muflihah, H., Lin, L., Xia, Y., Sierro, F., Palendira, M., Feng, C., Bertolino, P., Stambas, J., Triccas, J., Britton, W. (2018). Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis. Mucosal Immunology, 11(6), 1743-1752. [More Information]

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2017

Sierro, F., Evrard, M., Rizzetto, S., Melino, M., Mitchell, A., Florido, M., Beattie, L., Walters, S., Tay, S., Lu, B., Roediger, B., Wong, Y., Warren, A., Ritchie, W., McGuffog, C., Weninger, W., Le Couteur, D., Britton, W., Saunders, B., McCaughan, G., Bowen, D., Bertolino, P., et al (2017). A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment. Immunity, 47(2), 374-388. [More Information]
Wang, X., Holz, L., Chowdhury, S., Cordoba, S., Evans, K., Gall, M., Vieira de Ribeiro, A., Zheng, Y., Levy, M., Yu, M., Yao, T., Polak, N., Jolly, C., Bertolino, P., McCaughan, G., Gorrell, M. (2017). The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury. Immunology and Cell Biology, 95(5), 443-453. [More Information]
Lovelace, M., Powter, E., Coleman, P., Zhao, Y., Parker, A., Chang, G., Lay, A., Hunter, J., McGrath, A., Jormakka, M., Bertolino, P., McCaughan, G., Vadas, M., Gamble, J., et al (2017). The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells. Molecular Biology of the Cell, 28(8), 1066-1078. [More Information]
McNamara, H., Cai, Y., Wagle, M., Sontani, Y., Roots, C., Miosge, L., O'Connor, J., Sutton, H., Ganusov, V., Bertolino, P. (2017). Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids. Science Immunology, 2(9), 1-21. [More Information]

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2016

Vo, M., Holz, L., Wong, Y., English, K., Benseler, V., McGuffog, C., Azuma, M., McCaughan, G., Bowen, D., Bertolino, P. (2016). Effector T cell function rather than survival determines extent and duration of hepatitis in mice. Journal of Hepatology, 64(6), 1327-1338. [More Information]
Fernandez-Ruiz, D., Ng, W., Holz, L., Ma, J., Zaid, A., Wong, Y., Lau, L., Mollard, V., Cozijnsen, A., Collins, N., Tay, S., Bowen, D., Bertolino, P., et al (2016). Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection. Immunity, 45(4), 889-902. [More Information]
Wong, Y., McCaughan, G., Bowen, D., Bertolino, P. (2016). The CD8 T-cell response during tolerance induction in liver transplantation. Clinical & Translational Immunology, 5(10), 1-12. [More Information]

2015

Powter, E., Coleman, P., Tran, M., Lay, A., Bertolino, P., Parton, R., Vadas, M., Gamble, J. (2015). Caveolae control the anti-inflammatory phenotype of senescent endothelial cells. Aging Cell, 14(1), 102-111. [More Information]
McCaughan, G., Bertolino, P., Bowen, D. (2015). Could the morning after liver transplant be immunologically interesting? Liver Transplantation, 21(9), 1120-1122. [More Information]
Wong, Y., Tay, S., McCaughan, G., Bowen, D., Bertolino, P. (2015). Immune outcomes in the liver: Is CD8 T cell fate determined by the environment? Journal of Hepatology, 63(4), 1005-1014. [More Information]
Guo, J., McQuillan, J., Yau, B., Tullo, G., Long, C., Bertolino, P., Roediger, B., Weninger, W., Taylor, G., Hunt, N., Ball, H., et al (2015). IRGM3 Contributes to Immunopathology and Is Required for Differentiation of Antigen-Specific Effector CD8 T Cells in Experimental Cerebral Malaria. Infection and Immunity, 83(4), 1406-1417. [More Information]
Bertolino, P., Bowen, D. (2015). Malaria and the liver: immunological hide-and-seek or subversion of immunity from within? Frontiers in Microbiology, 6(FEB), 1-15. [More Information]
Brockhausen, J., Tay, S., Grzelak, C., Bertolino, P., Bowen, D., d'Avigdor, W., Teoh, N., Pok, S., Shackel, N., Gamble, J., Vadas, M., et al (2015). miR-181a mediates TGF-Î²-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer. Liver International, 35(1), 240-253. [More Information]
Bolton, H., Zhu, E., Terry, A., Guy, T., Koh, W., Tan, S., Power, C., Bertolino, P., Lahl, K., Sparwasser, T., Shklovskaya, E., Fazekas de St Groth, B. (2015). Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. Journal of Clinical Investigation, 125(9), 3627-3641. [More Information]
Sierro, F., Tay, S., Warren, A., Le Couteur, D., McCaughan, G., Bowen, D., Bertolino, P. (2015). Suicidal Emperipolesis: A process leading to cell-in-cell structures, T cell clearance and immune homeostasis. Current Molecular Medicine, 15(9), 819-827. [More Information]
Le Couteur, D., Tay, S., Solon-Biet, S., Bertolino, P., McMahon, A., Cogger, V., Colakoglu, F., Warren, A., Holmes, A., Pichaud, N., Raubenheimer, D., Simpson, S., et al (2015). The influence of macronutrients on splanchnic and hepatic lymphocytes in aging mice. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences, 70(12), 1499-1507. [More Information]

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2014

Tay, S., Wong, Y., McDonald, D., Wood, N., Roediger, B., Sierro, F., McGuffog, C., Alexander, I., Bishop, A., Gamble, J., Weninger, W., McCaughan, G., Bertolino, P., Bowen, D. (2014). Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2540-E2549. [More Information]
Bowen, D., Bertolino, P. (2014). Immune Responses to the Hepatitis C Virus. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 476-486). New York: Springer Science+Business Media. [More Information]
Tay, S., Wong, Y., Roediger, B., Sierro, F., Lu, B., McDonald, D., McGuffog, C., Meyer, N., Alexander, I., Parish, I., Weninger, W., Bishop, A., Gamble, J., McCaughan, G., Bertolino, P., Bowen, D., et al (2014). Intrahepatic activation of naive CD4+T cells by liver-resident phagocytic cells. Journal of Immunology, 193(5), 2087-2095. [More Information]
Bertolino, P., Bowen, D. (2014). Primary T-Cell Activation in Liver. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 899-905). New York: Springer Science+Business Media. [More Information]
Le Couteur, D., Warren, A., Cogger, V., Bertolino, P. (2014). Ultrastructure of the Liver Sinusoid. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 1235-1240). New York: Springer Science+Business Media. [More Information]

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2013

Tay, S., Lu, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A., Cowan, P., McCaughan, G., Dwyer, K., Bowen, D., et al (2013). Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation. Liver Transplantation, 19(11), 1224-1235. [More Information]
Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
McCaughan, G., Bowen, D., Bertolino, P. (2013). Operational tolerance in liver transplantation: Shall we predict or promote? Liver Transplantation, 19(9), 933-936. [More Information]
Chowdhury, S., Chen, Y., Yao, T., Ajami, K., Wang, X., Popov, Y., Schuppan, D., Bertolino, P., McCaughan, G., Yu, M., Gorrell, M. (2013). Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World Journal of Gastroenterology, 19(19), 2883-2893. [More Information]

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2012

Holz, L., Benseler, V., Vo, M., McGuffog, C., Van Rooijen, N., McCaughan, G., Bowen, D., Bertolino, P. (2012). Naive CD8 T cell activation by liver bone marrow-derived cells leads to a "neglected" IL-2(low) Bim(high) phenotype, poor CTL function and cell death. Journal of Hepatology, 57(4), 830-836. [More Information]
Bishop, A., Bertolino, P., Bowen, D., McCaughan, G. (2012). Tolerance in liver transplantation. Best Practice & Research: Clinical Gastroenterology, 26(1), 73-84. [More Information]
Barbier, L., Tay, S., McGuffog, C., Triccas, J., McCaughan, G., Bowen, D., Bertolino, P. (2012). Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation. Journal of Hepatology, 57(2), 352-358. [More Information]

2011

Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16735-16740. [More Information]
Benseler, V., Tay, S., Bowen, D., Bertolino, P. (2011). Role of the Hepatic Parenchyma in Liver Transplant Tolerance: a Paradigm Revisited. Digestive Diseases, 29(4), 391-401. [More Information]
Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
Warren, A., Benseler, V., Cogger, V., Bertolino, P., Le Couteur, D. (2011). The Impact of Poloxamer 407 on the Ultrastructure of the Liver and Evidence for Clearance by Extensive Endothelial and Kupffer Cell Endocytosis. Toxicologic Pathology, 39(2), 390-397. [More Information]

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2010

Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
Viebahn, C., Benseler, V., Holz, L., Elsegood, C., Vo, M., Bertolino, P., Ganss, R., Yeoh, G. (2010). Invading macrophages play a major role in the liver progenitor cell response to chronic liver injury. Journal of Hepatology, 53(3), 500-507. [More Information]
Holz, L., Bowen, D., Bertolino, P. (2010). Mechanisms of T cell death in the liver: to Bim or not to Bim? Digestive Diseases, 28(1), 14-24. [More Information]

2009

McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.
Dahlke, M., Hoogduijn, M., Eggenhofer, E., Popp, F., Renner, P., Slowik, P., Rosenauer, A., Piso, P., Bertolino, P., Schlitt, H., et al (2009). Toward MSC in Solid Organ Transplantation: 2008 Position Paper of the MISOT Study Group. Transplantation, 88, 614-619. [More Information]

2008

Allen, K., Mifsud, N., Williamson, R., Bertolino, P., Hardikar, W. (2008). Cell-mediated rejection results in allograft loss after liver cell transplantation. Liver Transplantation, 14(5), 688-694. [More Information]
Bertolino, P., McCaughan, G., Bowen, D. (2008). Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In Emilio Jirillo (Eds.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications, (pp. 39-70). United States: Springer. [More Information]
Bertolino, P. (2008). Impaired function of dendritic cells translocating the liver sinusoids: a veto effect contributing to intrahepatic tolerance? European Journal of Immunology, 38(4), 938-941. [More Information]
Bertolino, P. (2008). Interleukin-22, interleukin-17, and other cytokines: a wall is coming down. Hepatology, 47(1), 345-348. [More Information]
Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., D'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008). Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology, 135(3), 989-997. [More Information]
Holz, L., McCaughan, G., Benseler, V., Bertolino, P., Bowen, D. (2008). Liver tolerance and the manipulation of immune outcomes. Inflammation and Allergy: Drug Targets, 7(1), 6-18. [More Information]

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2007

Bertolino, P., Bowen, D., Benseler, V. (2007). T cells in the liver: there is life beyond the graveyard. Hepatology, 45(6), 1580-1582. [More Information]
Benseler, V., McCaughan, G., Schlitt, H., Bishop, A., Bowen, D., Bertolino, P. (2007). The liver: a special case in transplantation tolerance. Seminars in Liver Disease, 27(2), 194-213. [More Information]
Wu, H., Chen, G., Wyburn, K., Bertolino, P., Eris, J., Alexander, S., Sharland, A., Chadban, S. (2007). TLR4 activation mediates kidney ischemia/reperfusion injury. Journal of Clinical Investigation, 117(10), 2847-2859. [More Information]
Bertolino, P., Holz, L. (2007). Toll-like receptor-3 and the regulation of intrahepatic immunity: implications for interferon-alpha therapy. Hepatology, 45(1), 250-251. [More Information]

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2006

Wang, C., Cordoba, S., Bertolino, P., Alexander, S., Wu, M., Allen, R., McCaughan, G., Bishop, A. (2006). Examination of the immune mechanism of spontaneous tolerance of renal allografts in a mouse model. Immunology and Cell Biology, 84(1), A29-30.
Benseler, V., Holz, L., Schlitt, H., Brinkmann, V., McCaughan, G., Bertolino, P. (2006). FTY720 treatment leads to sequestration but not accumulation of antigen-specific CD8+ T cells activated in lymph nodes.
Dahlke, M., Loi, R., Warren, A., Holz, L., Popp, F., Weiss, D., Piso, P., Bowen, D., McCaughan, G., Schlitt, H., Bertolino, P. (2006). Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology, 44(2), 334-341. [More Information]
Bertolino, P., McCaughan, G., Le Couteur, D., Warren, A., Fraser, R., Benseler, V. (2006). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. [More Information]
Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]

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2005

Bertolino, P., Bowen, D., Zen, M., McCaughan, G. (2005). Autoimmune hepatitis in transgenic mouse models: what lessons can be learnt? In H. P. Dienes, U. Leuschner, A. W. Lohse, M. P. Manns (Eds.), Autoimmune Liver Disease: Proceedings of the Falk Symposium No. 142, (pp. 60-72). The Netherlands: Springer.
Bertolino, P., Schrage, A., Bowen, D., Klugewitz, K., Ghani, S., Eulenburg, K., Holz, L., Hogg, N., McCaughan, G., Hamann, A. (2005). Early intrahepatic antigen-specific retention of naÃ¯ve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology, 42(5), 1063-1071. [More Information]
Cordoba, S., Wang, C., Li, J., Bertolino, P., McCaughan, G., Bishop, A. (2005). Examination of immune mechanisms in a mouse model of spontaneous renal allograft acceptance. Immunology and Cell Biology, 83(4 Supplement), A20-A21.
Warren, A., Bertolino, P., Cogger, V., McLean, A., Fraser, R., Le Couteur, D. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40(10), 807-812. [More Information]
Bowen, D., McCaughan, G., Bertolino, P. (2005). Intrahepatic immunity: a tale of two sites? Trends in Immunology, 26(10), 512-517. [More Information]
Sun, J., Tumurbaatar, B., Jia, J., Diao, H., Bodola, F., Lemon, S., Tang, W., Bowen, D., McCaughan, G., Bertolino, P., et al (2005). Parenchymal expression of CD86/B7.2 contributes to hepatitis C virus-related liver injury. Journal of Virology, 79(16), 10730-10739. [More Information]
Holz, L., Benseler, V., Gengos, M., Newtown, R., McCaughan, G., Bertolino, P. (2005). Phenotype of CD8+ T cells activated in the liver. Tissue Antigens: immune response genetics, 66(5), 444 (Abstract 279)-444.
Benseler, V., Warren, A., Holz, L., Gengos, M., Bowen, D., Le Couteur, D., Schlitt, H., McCaughan, G., Bertolino, P. (2005). The liver promotes antigen-specific retention and rapid clearance of naive CD8(+) T cells activated in situ. Tissue Antigens: immune response genetics, 66(5), 359-360.

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2004

McCaughan, G., Bertolino, P., Bowen, D., Zen, M., Holz, L., Davis, T. (2004). The Site Of Primary T Cell Activation Is A Determinant Of The Balance Between Intrahepatic Tolerance And Immunity. Journal of Clinical Investigation, 114(5), 701-712. [More Information]

2002

Demangel, C., Bertolino, P., Britton, W. (2002). Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production. European Journal of Immunology, 32(4), 994-1002.
Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas de St Groth, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264. [More Information]
Greenhalgh, C., Bertolino, P., Asa, S., Metcalf, D., Corbin, J., Adams, T., Davey, H., Nicola, N., Hilton, D., Alexander, W. (2002). Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b). Molecular Endocrinology, 16(6), 1394-1406. [More Information]
Bertolino, P., McCaughan, G., Bowen, D. (2002). Role of primary intrahepatic T-cell activation in the 'liver tolerance effect'. Immunology and Cell Biology, 80(1), 84-92. [More Information]

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2001

Bertolino, P., Bowen, D., McCaughan, G., Fazekas de St Groth, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.

Selected Grants

2021

The APRICA program- Accelerated translational research in PRImary Liver Cancer, George J, McCaughan G, Reddel R, Bertolino P, Palendira M, Eslam M, Usherwood T, Cancer Institute NSW/Accelerated Translational Research Grant

2017

Protecting against malaria through liver-resident memory T cells, Bertolino P, Fernandez-Ruiz D, Bowen D, National Health and Medical Research Council (NHMRC)/Project Grants
The unique nature of gamma delta T cell recognition resolved through interaction with H2-Q10, Bertolino P, National Health and Medical Research Council (NHMRC)/Project Grants

2015

Refrigerated Incubator and Analytical Apparatus, McCaughan G, Gorrell M, Sharland A, Haber P, Church W, Bertolino P, National Health and Medical Research Council (NHMRC)/Equipment Grant
Novel therapy approaches for diabetes and its liver and heart complications, Gorrell M, Keane F, Tu T, Shackel N, Bowen D, Bertolino P, Seth D, Chen J, Cook A, Liu R, Zheng X, Gamble J, McCaughan G, Rebecca L Cooper Medical Research Foundation/Research Support

2014

Upgrade Suite for Multiphoton Microscopes , Weninger W, King N, Triccas J, Bertolino P, Jolly C, DVC Research/Equipment Grant
Unraveling mechanisms of liver transplant tolerance, Bertolino P, Bowen D, McCaughan G, Dwyer K, National Health and Medical Research Council (NHMRC)/Project Grants

2013

Gene therapy vectors to investigate intrahepatic immunity, Bertolino P, DVC Research/Bridging Support Grant

2012

QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system, Weninger W, Fazekas de St Groth B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C, National Health and Medical Research Council (NHMRC)/Equipment Grant
Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning, Gamble J, Feng C, McCaughan G, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M, National Health and Medical Research Council (NHMRC)/Equipment Grant

2010

Deciphering mechanisms of liver allograft tolerance, Bertolino P, Dwyer K, Bowen D, Bishop A, National Health and Medical Research Council (NHMRC)/Project Grants

2009

Next-generation high-speed flow cytometric cell sorter, Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons J, Sword G, National Health and Medical Research Council (NHMRC)/Equipment Grant
Inflammation, Angiogenesis and Cancer, Vadas M, McCaughan G, Gamble J, Bertolino P, Xia P, National Health and Medical Research Council (NHMRC)/Program Grants

2008

Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility, King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D, National Health and Medical Research Council (NHMRC)/Equipment Grant
Inverted Multiphoton Intravital Microscope, Gorrell M, Weninger W, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N, National Health and Medical Research Council (NHMRC)/Equipment Grant
Understanding the role of resident and donor leucocytes in liver and solid organ transplantation, Bertolino P, Roche Organ Transplant Research Foundation (Switzerland)/Research Support

2007

Career Awards: Research Fellowship, Bertolino P, National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships

2006

Understanding rapid T-cell clearance by the liver: a critical step towards improved liver transplantation., Bertolino P, Bishop A, National Health and Medical Research Council (NHMRC)/Project Grants

2004

FACS Aria for the University of Sydney Flow Cytometry Facility, Abendroth A, Armour C, Balcar V, Barnetson R, Bertolino P, Bishop A, Black J, Briscoe H, Byrne S, Christie M, Christopherson R, Cook D, Day M, Dong Q, Gillies M, Gorrell M, Halliday G, Hambly B, Hughes M, Hunt N, King N, Lovicu F, Madigan M, Mason R, McAvoy J, McCaughan G, Menzies S, Murphy C, Pollard J, Pollock C, Rasko J, Reeve V, University of Sydney/Equipment Grant

2000

Transgenic mice: a unique model to reassess specific T cell suppression, Bertolino P, National Health and Medical Research Council (NHMRC)/Project Grants

1999

Role of hepatocytes in inducing primary CD8+ T cell activation and tolerance, Bertolino P, National Health and Medical Research Council (NHMRC)/Project Grants

In the media

Interview with Norman Swan at ABC Radio Nationa- Health reports 26th September 2011

Link: http://www.abc.net.au/radionational/programs/healthreport/important-new-liver-research/3582398

Faculty of Medicine and Health

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Associate Professor Patrick Bertolino

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In the media