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Dr Paul Bonnitcha
BSc (Adv) Hons, MSc, D.Phil (Oxon), MBBS, MRACI CChem, FAACB, FRCPA
Clinical Senior Lecturer
Central Clinical School and Northern Clinical School
Clinical Senior Lecturer
Central Clinical School and Northern Clinical School
Dr Bonnitcha is a Chemical Pathologist at Royal North Shore and St Vincent's Hospital and a Senior Clinical Lecturer at the Northern and Central Clinical Schools in the Medical Faculty. He completed his medical degree at the University of Sydney before undertaking Internship and Residency at RNSH. He subsequently completed his Fellowship with the Royal College of Pathologists at NSW Health Pathology.
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- Metabolomics
- Translational Research
- Mass Spectrometry
- Hypoxia and its role in pathological processes
- Atherosclerosis
- Oncology
- Medicinal Chemistry and Drug Design
- Biochemistry
- Metabolomics
- Hypoxia
- Drug design
Investigating blood biomarkers in cardiovacular disease (PhD project)
NAFLD biomarkers
Royal College of Pathologists of Australasia - Fellow
Australasian Association of Clinical Biochemists - Fellow
Royal Australian Chemistry Institute (RACI) - Chartered Chemist
- RCPA Quality Assurance Grant 2020
- Sydney Medical School Foundation Fellowship 2016
- Junior Medical Officer Teaching Award, Royal North Shore Hospital 2015
- Professor CRB Blackburn Prize, Sydney Medical Program 2014
- Junior Medical Officer Teaching Award, Royal North Shore Hospital 2014
- Sydney Medical Program Elective Scholarship 2013
- Centennial Trust Scholarship, Old Newingtonian Union 2012
- USMLE Scholarship (declined), Sydney Medical Program 2011
- Commonwealth Scholarship, Oxford University, United Kingdom 2005 - 2009
- Agnes Campbell Prize, University of Sydney, School of Chemistry 2005
- University of Sydney Postgraduate Award 2005
- University Medal (Chemistry), University of Sydney 2004
- Honours Scholarship (Merit), University of Sydney 2004
- Royal Australian Chemistry Institute Masson Memorial Scholarship Prize 2004
- Science Faculty Dean’s Honour List, University of Sydney 2001 - 2003
- Walter Burfitt Scholarship No 1, University of Sydney, Chemistry Faculty 2003
- University Senate Scholarship, Sydney University Sport Union 2002
- International Exchange Scholarship, University of Sydney 2002
- Continuing Undergraduate Scholarship, University of Sydney 2002
- Yachting NSW Nomination for Senior Sailor of the Year 2002
- Golden Key International Honour Society Scholastic Scholarship 2002
- Levee No. 1 Scholarship for Physics, University of Sydney, Physics Faculty 2001
- Science Entry Scholarship, University of Sydney, Science Faculty 2001
- Science Alumni Scholarship, University of Sydney, Science Faculty 2001
- E Trenchard Miller Scholarship, University of Sydney 2001
Obesity, Diabetes and Cardiovascular Disease, Cancer
Publications
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Journals
- Scheinberg, T., Mahon, K., Sullivan, D., Meikle, P., Horvath, L., Lin, H., Fitzpatrick, M., Azad, A., Bonnitcha, P., Davies, A., Heller, G., Mak, B., et al (2023). PCPro: a clinically accessible, circulating lipid biomarker signature for poor-prognosis metastatic prostate cancer. Prostate Cancer and Prostatic Diseases. [More Information]
- Bonnitcha, P., Rigdwell, M., Ward, P., Chesher, D. (2023). Standard - 20 ° C freezer storage protocols may cause substantial plasma renin cryoactivation. Clinical Chemistry and Laboratory Medicine. [More Information]
- Bonnitcha, P., Sullivan, D., Fitzpatrick, M., Ireland, A., Nguyen, V., Koay, Y., O'Sullivan, J. (2022). Design and validation of an LC-MS/MS method for simultaneous quantification of asymmetric dimethylguanidino valeric acid, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma. Pathology, 54(5), 591-598. [More Information]
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2023
- Scheinberg, T., Mahon, K., Sullivan, D., Meikle, P., Horvath, L., Lin, H., Fitzpatrick, M., Azad, A., Bonnitcha, P., Davies, A., Heller, G., Mak, B., et al (2023). PCPro: a clinically accessible, circulating lipid biomarker signature for poor-prognosis metastatic prostate cancer. Prostate Cancer and Prostatic Diseases. [More Information]
- Bonnitcha, P., Rigdwell, M., Ward, P., Chesher, D. (2023). Standard - 20 ° C freezer storage protocols may cause substantial plasma renin cryoactivation. Clinical Chemistry and Laboratory Medicine. [More Information]
2022
- Bonnitcha, P., Sullivan, D., Fitzpatrick, M., Ireland, A., Nguyen, V., Koay, Y., O'Sullivan, J. (2022). Design and validation of an LC-MS/MS method for simultaneous quantification of asymmetric dimethylguanidino valeric acid, asymmetric dimethylarginine and symmetric dimethylarginine in human plasma. Pathology, 54(5), 591-598. [More Information]
2021
- Lin, H., Mak, B., Yeung, N., Huynh, K., Meikle, T., Mellett, N., Kwan, E., Fettke, H., Tran, B., Davis, I., Mahon, K., Zhang, A., Stockler, M., Marx, G., Stricker, P., Scheinberg, T., Bonnitcha, P., Sullivan, D., Joshua, A., Horvath, L., et al (2021). Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase. EBioMedicine, 72, 103625. [More Information]
- Fitzpatrick, M., Bonnitcha, P., Nguyen, V. (2021). Streamlined three step total vitamin C analysis by HILIC-UV for laboratory testing. Clinical Chemistry and Laboratory Medicine, 59(12), 1944-1949. [More Information]
2018
- Bonnitcha, P., Grieve, S., Figtree, G. (2018). Clinical imaging of hypoxia: Current status and future directions. Free Radical Biology and Medicine, 126, 296-312. [More Information]
- Sullivan, D., Bonnitcha, P., Spinks, C., Keech, A. (2018). PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Status and Protection Against Ischemic Stroke: PheWAS, TreWAS, and More. Circulation. Genomic and Precision Medicine, 11(7), 1-3. [More Information]
2017
- O'Neill, E., Kolanowski, J., Bonnitcha, P., New, E. (2017). A cobalt(II) complex with unique paraSHIFT responses to anions. Chemical Communications, 53(25), 3571-3574. [More Information]
- O'Neill, E., Kaur, A., Bishop, D., Shishmarev, D., Kuchel, P., Grieve, S., Figtree, G., Renfrew, A., Bonnitcha, P., New, E. (2017). Hypoxia-responsive cobalt complexes in tumor spheroids: Laser ablation inductively coupled plasma mass spectrometry and magnetic resonance imaging studies. Inorganic Chemistry, 56(16), 9860-9868. [More Information]
2016
- O'Neill, E., Kolanowski, J., Yin, G., Broadhouse, K., Grieve, S., Renfrew, A., Bonnitcha, P., New, E. (2016). Reversible magnetogenic cobalt complexes. RSC Advances, 6(36), 30021-30027. [More Information]
2014
- Betts, H., Pascu, S., Buchard, A., Bonnitcha, P., Dilworth, J. (2014). One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(II) complexes. RSC Advances, 4(25), 12964-12970. [More Information]
2013
- Zhang, J., Bonnitcha, P., Wexselblatt, E., Klein, A., Najajreh, Y., Gibson, D., Hambley, T. (2013). Facile preparation of mono-, di- and mixed-carboxylato platinum(IV) complexes for versatile anticancer prodrug design. Chemistry - A European Journal, 19(5), 1672-1676. [More Information]
2012
- Bonnitcha, P., Kim, B., Hocking, R., Clegg, J., Turner, P., Neville, S., Hambley, T. (2012). Cobalt complexes with tripodal ligands: Implications for the design of drug chaperones. Dalton Transactions, 41(37), 11293-11304. [More Information]
2010
- Bonnitcha, P., Bayly, S., Theobald, M., Betts, H., Lewis, J., Dilworth, J. (2010). Nitroimidazole conjugates of bis(thiosemicarbazonato)64Cu(II) - Potential combination agents for the PET imaging of hypoxia. Journal of Inorganic Biochemistry, 104(2), 126-135. [More Information]
- Carroll, L., Bejot, R., Hueting, R., King, R., Bonnitcha, P., Bayly, S., Christlieb, M., Dilworth, J., Gee, A., Declerck, J., et al (2010). Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes. Chemical Communications, 46(23), 4052-4054. [More Information]
2009
- Holland, J., Jones, M., Bonnitcha, P., Lewis, J., Dilworth, J. (2009). Functionalised copper-64 complexes as precursors of potential PET imaging agents for neurodegenerative disorders. New Journal of Chemistry, 33(9), 1845-1852. [More Information]
2008
- Yamamoto, N., Danos, S., Bonnitcha, P., Failes, T., New, E., Hambley, T. (2008). Cellular uptake and distribution of cobalt complexes of fluorescent ligands. Journal of Biological Inorganic Chemistry, 13(6), 861-871. [More Information]
2006
- Bonnitcha, P., Hall, M., Underwood, C., Foran, G., Zhang, M., Beale, P., Hambley, T. (2006). XANES investigation of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes. Journal of Inorganic Biochemistry, 100(5-6), 963-971. [More Information]
Selected Grants
2020
- The development of a quality assurance pilot program for proficiency testing in cardiovascular disease, Bonnitcha P, Sullivan D, Royal College of Pathologists of Australasia/Quality Assurance Programs Research Grant
2016
- Positron Emission Tomography for the Detection of Vulnerable Plaques, Bonnitcha P, Sydney Medical School Foundation/Foundation Grant
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