2024

• Mohammadi, N., Ahring, J., Liao, V., Chua, H., Ortiz de la Rosa, S., Johannesen, K., Michaeli-Yossef, Y., Vincent-Devulder, A., Meridda, C., Absalom, N., et al (2024). Distinct neurodevelopmental and epileptic phenotypes associated with gain- and loss-of-function GABRB2 variants. EBioMedicine, 106, 105236. [More Information]
• Absalom, N., El-Kamand, S., Chua, H., Ahring, J. (2024). Follow the allosteric transitions to predict variant pathogenicity: a channel-specific approach. Brain. [More Information]
• Musto, E., Delaby, D., Ceulemans, B., Weckhuysen, S., Sparber, P., Bouman, A., Ardern-Holmes, S., Troedson, C., Battaglia, D., Goel, H., Liao, V., Collins, M., Ahring, J., Kothur, K., Bennetts, B., et al (2024). GABRA1-Related Disorders: From Genetic to Functional Pathways. Annals of Neurology, 95(1), 27-41. [More Information]

2023

• Absalom, N., Lin, S., Liao, V., Chua, H., Moller, R., Collins, M., Ahring, J. (2023). GABAA receptors in epilepsy: Elucidating phenotypic divergence through functional analysis of genetic variants. Journal of Neurochemistry. [More Information]
• Gjerulfsen, C., Mieszczanek, T., Johannesen, K., Liao, V., Collins, M., Nørby, H., Gardella, E., Rubboli, G., Ahring, J., Møller, R. (2023). Vinpocetine improved neuropsychiatric and epileptic outcomes in a patient with a GABRA1 loss-of-function variant. Annals of Clinical and Translational Neurology, 10(8), 1493-1498. [More Information]

2022

• Johannesen, K., Gardella, E., Ahring, J., Møller, R. (2022). De novo SCN3A missense variant associated with self-limiting generalized epilepsy with fever sensitivity. European Journal of Medical Genetics, 65(10). [More Information]
• Absalom, N., Liao, V., Johannesen, K., Gardella, E., Jacobs, J., Lesca, G., Gokce-Samar, Z., Arzimanoglou, A., Zeidler, S., Striano, P., Collins, M., Ahring, J., et al (2022). Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies. Nature Communications, 13(1), 1822. [More Information]
• Ahring, J., Liao, V., Gardella, E., Johannesen, K., Krey, I., Selmer, K., Stadheim, B., Davis, H., Peinhardt, C., Koko, M., Collins, M., et al (2022). Gain-of-function variants in GABRD reveal a novel pathway for neurodevelopmental disorders and epilepsy. Brain, 145(4), 1299-1309. [More Information]
• Ahring, J., Liao, V., Lin, S., Absalom, N., Collins, M., Moller, R. (2022). The de novo GABRA4 p.Thr300Ile variant found in a patient with early-onset intractable epilepsy and neurodevelopmental abnormalities displays gain-of-function traits. Epilepsia, 63(9), 2439-2441. [More Information]

2021

• Liao, V., Collins, M., Ahring, J. (2021). Efficient expression of concatenated α1β2δ and α1β3δ GABAA receptors, their pharmacology and stoichiometry. British Journal of Pharmacology, 178(7), 1556-1573. [More Information]

2020

• Sandager-Nielsen, K., Ahring, J., Klein, J., van Hout, M., Thaneshwaran, S., dos Santos, A., Jacobsen, T., Amrutkar, D., Peters, D., Jensen, A., et al (2020). Characterization of AN317, a novel selective agonist of α6β2-containing nicotinic acetylcholine receptors. Biochemical Pharmacology, 174, 113786. [More Information]
• van Hout, M., Klein, J., Ahring, J., Brown, D., Thaneshwaran, S., dos Santos, A., Jensen, A., Kohlmeier, K., Christophersen, P., Dyhring, T. (2020). Characterization of AN6001, a positive allosteric modulator of alpha 6 beta 2-containing nicotinic acetylcholine receptors. Biochemical Pharmacology, 174, 113788. [More Information]
• Absalom, N., Liao, V., Kothur, K., Indurthi Venkata, D., Bennetts, B., Troedson, C., Mohammad, S., Gupta, S., McGregor, I., Bowen, M., Ahring, J., Collins, M., et al (2020). Gain-of-function GABRB3 variants identified in vigabatrin-hypersensitive epileptic encephalopathies. Brain Communications, 2(2), fcaa162. [More Information]
• Liao, V., Kusay, A., Balle, T., Ahring, J. (2020). Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs. British Journal of Pharmacology, 177(18), 4275-4295. [More Information]
• Oddsson, S., Kowal, N., Ahring, J., Olafsdottir, E., Balle, T. (2020). Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the alpha-7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation. Molecules, 25(12), 25122872. [More Information]
• Richter, G., Liao, V., Ahring, J., Chebib, M. (2020). The Z-Drugs Zolpidem, Zaleplon, and Eszopiclone Have Varying Actions on Human GABA-A Receptors Containing gamma-1, gamma-2, and gamma-3 Subunits. Frontiers in Neuroscience, 14, 599812. [More Information]

2019

• Liao, V., Chua, H., Kowal, N., Collins, M., Balle, T., Ahring, J. (2019). Concatenated y-aminobutyric acid type A receptors revisited: Finding order in chaos. Journal of General Physiology, 151(6), 798-819. [More Information]
• Absalom, N., Ahring, J., Liao, V., Balle, T., Jiang, T., Anderson, L., Arnold, J., McGregor, I., Bowen, M., Chebib, M. (2019). Functional genomics of epilepsy-associated mutations in the GABAa receptor subunits reveal that one mutation impairs function and two are catastrophic. Journal of Biological Chemistry, 294(15), 6157-6171. [More Information]
• Kowal, N., Indurthi, D., Ahring, J., Chebib, M., Olafsdottir, E., Balle, T. (2019). Novel Approach for the Search for Chemical Scaffolds with Dual Activity with Acetylcholinesterase and the alpha-7 Nicotinic Acetylcholine Receptor-A Perspective for the Treatment of Neurodegenerative Disorders. Molecules, 24(3), 1-17. [More Information]
• Indurthi Venkata, D., Qudah, T., Liao, V., Ahring, J., Lewis, T., Balle, T., Collins, M., Absalom, N. (2019). Revisiting autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) mutations in the nicotinic acetylcholine receptor reveal an increase in efficacy regardless of stochiometry. Pharmacological Research, 139, 215-227. [More Information]
• Neumann, S., Boothman-Burrell, L., Gowing, E., Jacobsen, T., Ahring, J., Young, S., Sandager-Nielsen, K., Clarkson, A. (2019). The Delta-Subunit Selective GABAA Receptor Modulator, DS2, Improves Stroke Recovery via an Anti-inflammatory Mechanism. Frontiers in Neuroscience, 13, 1-13. [More Information]
• Clarkson, A., Boothman-Burrell, L., Dosa, Z., Nagaraja, R., Jin, L., Parker, K., van Nieuwenhuijzen, P., Neumann, S., Gowing, E., Gavande, N., Ahring, J., Hanrahan, J., Chebib, M., et al (2019). The flavonoid, 2'-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia. Journal of Cerebral Blood Flow and Metabolism, 39(7), 1266-1282. [More Information]

2018

• Ahring, J., Liao, V., Balle, T. (2018). Concatenated nicotinic acetylcholine receptors: A gift or a curse? Journal of General Physiology, 150(3), 453-473. [More Information]
• Kowal, N., Ahring, J., Liao, V., Indurti, D., Harvey, B., O'Connor, S., Collins, M., Olafsdottir, E., Balle, T. (2018). Galantamine is not a positive allosteric modulator of human alpha-4-beta-2 or alpha-7 nicotinic acetylcholine receptors. British Journal of Pharmacology, 175(14), 2911-2925. [More Information]
• Soderhielm, P., Balle, T., Bak-Nyhus, S., Zhang, M., Hansen, K., Ahring, P., Jensen, A. (2018). Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochemical Pharmacology, 158, 339-358. [More Information]

2016

• Ahring, J., Bang, L., Jensen, M., Strobaek, D., Hartiadi, L., Collins, M., Absalom, N. (2016). A pharmacological assessment of agonists and modulators at (alpha)4(beta)2(upsilon)2 and (alpha)4(beta)2(gamma) GABAA receptors: The challenge in comparing apples with oranges. Pharmacological Research, 111, 563-576. [More Information]
• Lee, H., Absalom, N., Hanrahan, J., van Nieuwenhuijzen, P., Ahring, J., Chebib, M. (2016). A pharmacological characterization of GABA, THIP and DS2 at binary alpha4Beta3 and Beta3delta receptors: GABA activates Beta3delta receptors via the Beta3(+)delta(-) interface. Brain Research, 1644, 222-230. [More Information]
• Gasiorek, A., Trattnig, S., Ahring, P., Kristiansen, U., Frolund, B., Frederiksen, K., Jensen, A. (2016). Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors. Biochemical Pharmacology, 110-111, 92-108. [More Information]
• Hartiadi, L., Ahring, J., Chebib, M., Absalom, N. (2016). High and low GABA sensitivity alpha4beta2delta GABAA receptors are expressed in Xenopus laevis oocytes with divergent stoichiometries. Biochemical Pharmacology, 103, 98-108. [More Information]
• Indurthi Venkata, D., Lewis, T., Ahring, J., Balle, T., Collins, M., Absalom, N. (2016). Ligand binding at the (alpha)4-(alpha)4 agonist-binding site of the (alpha)4(beta)2 nAChR triggers receptor activation through a pre-activated conformational state. PloS One, 11(8), 1-20. [More Information]
• Munro, G., Christensen, J., Erichsen, H., Dyhring, T., Demnitz, J., Dam, E., Ahring, J. (2016). NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats. CNS Neuroscience and Therapeutics, 22(2), 135-145. [More Information]
• Che Has, A., Absalom, N., van Nieuwenhuijzen, P., Clarkson, A., Ahring, J., Collins, M. (2016). Zolpidem is a potent stoichiometry-selective modulator of (alpha)1(beta)3 GABAA receptors: evidence of a novel benzodiazepine site in the (alpha)1-(alpha)1 interface. Scientific Reports, 6, 1-12. [More Information]

2015

• Shahsavar, A., Ahring, J., Olsen, J., Krintel, C., Kastrup, J., Balle, T., Gajhede, M. (2015). Acetylcholine-Binding Protein Engineered to Mimic the alpha4-alpha4 Binding Pocket in alpha4beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity. Molecular Pharmacology, 88(4), 697-707. [More Information]
• Ahring, J., Olsen, J., Nielsen, E., Peters, D., Pedersen, M., Rohde, L., Kastrup, J., Shahsavar, A., Indurthi Venkata, D., Chebib, M., Balle, T., et al (2015). Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface. Neuropharmacology, 92, 135-145. [More Information]
• Garcia de Lucas, A., Ahring, J., Larsen, J., Rivera-Arconada, I., Lopez-Garcia, J., Mirza, N., Munro, G. (2015). GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085. Biochemical Pharmacology, 93(3), 370-379. [More Information]

2014

• Rasmussen, A., Strobaek, D., Dyhring, T., Jensen, M., Peters, D., Grunnet, M., Timmermann, D., Ahring, P. (2014). Biophysical and pharmacological characterization of alpha6-containing nicotinic acetylcholine receptors expressed in HEK293 cells. Brain Research, 1542, 1-11. [More Information]
• Olsen, J., Balle, T., Gajhede, M., Ahring, J., Kastrup, J. (2014). Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors. PloS One, 9(3), 1-8. [More Information]
• Olsen, J., Ahring, J., Kastrup, J., Gajhede, M., Balle, T. (2014). Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-like Mechanism of Action at a4B2 Nicotinic Acetylcholine Receptors. Journal of Biological Chemistry, 289(36), 24911-24921. [More Information]

2013

• Dalby-Brown, W., Jessen, C., Hougaard, C., Jensen, M., Jacobsen, T., Sandager-Nielson, K., Erichsen, H., Grunnet, M., Ahring, P., et al (2013). Characterization of a novel high-potency positive modulator of Kv7 channels. European Journal of Pharmacology, 709, 52-63. [More Information]
• Harpsøe, K., Hald, H., Timmermann, D., Jensen, M., Dyhring, T., Nielsen, E., Peters, D., Balle, T., Gajhede, M., Kastrup, J., et al (2013). Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors. Journal of Biological Chemistry, 288(4), 2559-2570. [More Information]
• Ussing, C., Hansen, C., Petersen, J., Jensen, A., Rohde, L., Ahring, P., Nielsen, E., Kastrup, J., Gajhede, M., Frølund, B., Balle, T. (2013). Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists. Journal of Medicinal Chemistry, 56(3), 940-951. [More Information]
• Olsen, J., Kastrup, J., Peters, D., Gajhede, M., Balle, T., Ahring, J. (2013). Two Distinct Allosteric Binding Sites at a4B2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors. Journal of Biological Chemistry, 288(50), 35997-36006. [More Information]
• Grupe, M., Jensen, A., Ahring, P., Christensen, J., Grunnet, M. (2013). Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (alpha4)3(beta2)2 nicotinic ACh receptors. British Journal of Pharmacology, 168(8), 2000-2010. [More Information]

2012

• Trattnig, S., Harpsøe, K., Thygesen, S., Rahr, L., Ahring, P., Balle, T., Jensen, A. (2012). Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors: Inhibition and potentiation of cys-loop receptor signaling through a conserved transmembrane intersubunit site. Journal of Biological Chemistry, 287(30), 25241-25254. [More Information]
• Rohde, L., Ahring, P., Jensen, M., Nielsen, E., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, K., Gajhede, M., Kastrup, J., et al (2012). Intersubunit Bridge Formation Governs Agonist Efficacy at Nicotinic Acetylcholine (alpha)4(beta)2 Receptors:Unique role of halogen bonding revealed. Journal of Biological Chemistry, 287(6), 4248-4259. [More Information]
• Venskutonyte, R., Frydenvang, K., Hald, H., Ceravalls de Rabassa, A., Gajhede, M., Ahring, P., Kastrup, J. (2012). Kainate induces various domain closures in AMPA and kainate receptors. Neurochemistry International, 61(4), 536-545. [More Information]

2011

• Harpsøe, K., Ahring, P., Jensen, M., Christensen, J., Peters, D., Balle, T. (2011). Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors. Journal of Neuroscience, 31(30), 10759-10766. [More Information]

2009

• Tosco, P., Ahring, P., Dyhring, T., Peters, D., Harpsae, K., Liljefors, T., Balle, T. (2009). Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. Journal of Medicinal Chemistry, 52(8), 2311-2316. [More Information]

2006

• Audouze, K., Nielsen, E., Olsen, G., Ahring, P., Jørgensen, T., Peters, D., Liljefors, T., Balle, T. (2006). New Ligands with Affinity for the alpha4beta2 Subtype of Nicotinic Acetylcholine Receptors. Synthesis, Receptor Binding, and 3D-QSAR Modeling. Journal of Medicinal Chemistry, 49, 3159-3171. [More Information]