Associate Professor Qi Cao
Associate Professor
The Westmead Institute for Medical Research
Westmead Clinical School
Dr. Qi Cao is a Senior Research Fellow at the Westmead Institute for Medical Research, Westmead Clinical School, The University of Sydney. He is currently the Leader of the Renal Inflammation and Immunology Group within the Westmead Institute for Medical Research. He has longstanding research interests and extensive expertise in renal disease and immunotherapy, with a particular focus on the role of regulatory macrophages and their therapeutic potential in kidney disease.
- Chronic kidney disease
- Acute kidney injury
- Macrophage and Dendritic cell therapy
- Innate lymphoid cell biology
- Diabetes and islet transplantation
- Defining roles of innate lymphoid cells in chronic kidney disease for future therapy
- Defining the role of kidney CD103+Dendritic cells for treatment of chronic kidney disease
2016 Westmead Institute for Medical Research Science Award
2016 ANZSN Travel Grant
2015 Westmead Institute for Medical Research Science Award
2015 ANZSN Travel Grant
2015 Westmead Association Research Travel Grant
2014 ANZSN Travel Grant
2013 Westmead Association Research Travel Grant
2012 Kidney Health Australia Postgraduate Scholarship
2010 Westmead Millennium Institute Science Award
2010 Young Investigator Award of The ANZSN Congress
2007 Outstanding graduates of Shanghai Jiaotong University
Project title | Research student |
---|---|
Harnessing regulatory immune cells in kidney disease. | Jianwei CHEN |
Publications
Book Chapters
- Lee, V., Cao, Q., Wang, Y., Harris, D. (2011). Role of Macrophages in Renal Injury,Repair and Regeneration. In Michael S. Goligorsky (Eds.), Regenerative Nephrology, (pp. 125-139). USA: Elsevier.
Journals
- Peng, L., Zhang, W., Hu, L., Cao, Q., Wang, C., Zhang, Y., Li, W., Peng, G., Wei, D., Gou, L., et al (2024). Antibacterial and DNA-Based Hydrogels In Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding. Macromolecular Rapid Communications, 45(5), 2300559. [More Information]
- Chen, T., Cao, Q., Wang, R., Zheng, G., Azmi, F., Lee, V., Wang, Y., Li, H., Yu, D., Rogers, N., Harris, D., Wang, Y., et al (2023). Attenuation of renal injury by depleting cDC1 and by repurposing Flt3 inhibitor in anti-GBM disease. Clinical Immunology, 250. [More Information]
- Cao, Q., Wang, R., Niu, Z., Chen, T., Azmi, F., Read, S., Chen, J., Lee, V., Zhou, C., Julovi, S., Zheng, G., George, J., Wang, Y., et al (2023). Type 2 innate lymphoid cells are protective against hepatic ischaemia/reperfusion injury. JHEP Reports, 5(10), 100837-100837. [More Information]
2024
- Peng, L., Zhang, W., Hu, L., Cao, Q., Wang, C., Zhang, Y., Li, W., Peng, G., Wei, D., Gou, L., et al (2024). Antibacterial and DNA-Based Hydrogels In Situ Block TNF-α to Promote Diabetic Alveolar Bone Rebuilding. Macromolecular Rapid Communications, 45(5), 2300559. [More Information]
2023
- Chen, T., Cao, Q., Wang, R., Zheng, G., Azmi, F., Lee, V., Wang, Y., Li, H., Yu, D., Rogers, N., Harris, D., Wang, Y., et al (2023). Attenuation of renal injury by depleting cDC1 and by repurposing Flt3 inhibitor in anti-GBM disease. Clinical Immunology, 250. [More Information]
- Cao, Q., Wang, R., Niu, Z., Chen, T., Azmi, F., Read, S., Chen, J., Lee, V., Zhou, C., Julovi, S., Zheng, G., George, J., Wang, Y., et al (2023). Type 2 innate lymphoid cells are protective against hepatic ischaemia/reperfusion injury. JHEP Reports, 5(10), 100837-100837. [More Information]
2022
- Wang, C., Du, X., Fu, F., Li, X., Wang, Z., Zhou, Y., Gou, L., Li, W., Li, J., Zhang, J., Cao, Q., et al (2022). Adiponectin gene therapy prevents islet loss after transplantation. Journal of Cellular and Molecular Medicine, 26(18), 4847-4858. [More Information]
- Wang, Z., Li, W., Gou, L., Zhou, Y., Peng, G., Zhang, J., Liu, J., Li, R., Ni, H., Zhang, W., Cao, Q., et al (2022). Biodegradable and Antioxidant DNA Hydrogel as a Cytokine Delivery System for Diabetic Wound Healing. Advanced Healthcare Materials, 11(21). [More Information]
- Wang, R., Zhang, J., Li, D., Liu, G., Fu, Y., Li, Q., Zhang, L., Qian, L., Hao, L., Wang, Y., Harris, D., Cao, Q., et al (2022). Imbalance of circulating innate lymphoid cell subpopulations in patients with chronic kidney disease. Clinical Immunology, 239. [More Information]
2021
- Li, W., Wang, C., Lv, H., Wang, Z., Zhao, M., Liu, S., Gou, L., Zhou, Y., Li, J., Zhang, J., Cao, Q., et al (2021). A DNA Nanoraft-Based Cytokine Delivery Platform for Alleviation of Acute Kidney Injury. ACS Nano, 15(11), 18237-18249. [More Information]
- Chen, T., Cao, Q., Wang, R., Zheng, G., Azmi, F., Wang, J., Lee, V., Wang, Y., Yu, H., Patel, M., Rogers, N., Wang, Y., Harris, D., et al (2021). Conventional Type 1 Dendritic Cells (cDC1) in Human Kidney Diseases: Clinico-Pathological Correlations. Frontiers in Immunology, 12, 635212. [More Information]
- Wang, R., Wang, Y., Harris, D., Cao, Q. (2021). Innate lymphoid cells in kidney diseases. Kidney International, 99(5), 1077-1087. [More Information]
2020
- Huang, Q., Ma, X., Wang, Y., Niu, Z., Wang, R., Yang, F., Wu, M., Liang, G., Rong, P., Wang, H., Harris, D., Cao, Q., et al (2020). IL-10 producing type 2 innate lymphoid cells prolong islet allograft survival. EMBO Molecular Medicine, 12(11), 1-16. [More Information]
- Cao, Q., Wang, R., Wang, Y., Niu, Z., Chen, T., Wang, C., Jin, L., Huang, Q., Li, Q., Wang, X., Azmi, F., Lee, V., Zheng, G., Harris, D., et al (2020). Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury. Kidney International, 97(1), 130-142. [More Information]
- Wang, J., Lewis, J., Byrnes, E., Wong, G., Raymond, W., Zhu, K., Robertson, G., Lim, W., Cao, Q., Prince, R., Lee, V. (2020). Serum Midkine, estimated glomerular filtration rate and chronic kidney disease-related events in elderly women: Perth Longitudinal Study of Aging Women. Scientific Reports, 10(1), 14499. [More Information]
2019
- Li, Q., Cao, Q., Wang, C., Nguyen, H., Wang, X., Zheng, G., Wang, Y., Hu, S., Alexander, S., Harris, D., Wang, Y. (2019). Dendritic cell-targeted CD40 DNA vaccine suppresses Th17 and ameliorates progression of experimental autoimmune glomerulonephritis. Journal of Leukocyte Biology, 105(4), 809-819. [More Information]
- Yang, Y., Feng, X., Liu, X., Wang, Y., Hu, M., Cao, Q., Zhang, Z., Zhao, L., Zhang, J., Guo, R., Zheng, G., et al (2019). Fate alteration of bone marrow-derived macrophages ameliorates kidney fibrosis in murine model of unilateral ureteral obstruction. Nephrology Dialysis Transplantation, 34(10), 1657-1668. [More Information]
- Wang, R., Chen, T., Wang, C., Zhang, Z., Wang, X., Li, Q., Lee, V., Wang, Y., Zheng, G., Alexander, S., Wang, Y., Harris, D., Cao, Q. (2019). Flt3 inhibition alleviates chronic kidney disease by suppressing CD103(+) dendritic cell-mediated T cell activation. Nephrology Dialysis Transplantation, 34(11), 1853-1863. [More Information]
2018
- Li, Q., Liu, M., Fu, R., Cao, Q., Wang, Y., Han, S., Hu, W., Li, H., Hu, C., Wu, L., Wang, Y., et al (2018). Alteration of circulating innate lymphoid cells in patients with atherosclerotic cerebral infarction. American Journal of Translational Research, 10(12), 4322-4330.
- Cao, Q., Wang, Y., Niu, Z., Wang, C., Wang, R., Zhang, Z., Chen, T., Wang, X., Li, Q., Lee, V., Zheng, G., Harris, D., et al (2018). Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology, 29(3), 961-976. [More Information]
- Qiao, X., Rao, P., Zhang, Y., Liu, L., Pang, M., Wang, H., Hu, M., Tian, X., Zhang, J., Zhao, Y., Wang, C., Guo, F., Cao, Q., Wang, Y., Lee, V., Zheng, G., Harris, D., et al (2018). Redirecting TGF-[Beta] Signaling through the [Beta]-Catenin/Foxo Complex Prevents Kidney Fibrosis. Journal of the American Society of Nephrology, 29(2), 557-570. [More Information]
2017
- Li, Q., Ding, S., Wang, Y., Xu, X., Shen, Z., Fu, R., Liu, M., Hu, C., Zhang, C., Cao, Q., Wang, Y. (2017). Age-associated alteration in T17 cell response is related to endothelial cell senescence and atherosclerotic cerebral infarction. American Journal of Translational Research, 9(11), 5160-5168.
- Wang, Y., Zhang, G., Wang, Y., Hu, M., Zhou, J., Sawyer, A., Cao, Q., Wang, Y., Zheng, G., Lee, V., Harris, D., Alexander, S. (2017). Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2-interacting mediator knock-out mice. Clinical and Experimental Immunology, 188(2), 195-207. [More Information]
- Li, Q., Ming, T., Wang, Y., Ding, S., Hu, C., Zhang, C., Cao, Q., Wang, Y. (2017). Increased Th9 cells and IL-9 levels accelerate disease progression in experimental atherosclerosis. American Journal of Translational Research, 9(3), 1335-1343.
2016
- Zheng, G., Zhang, J., Zhao, H., Wang, H., Pang, M., Qiao, X., Lee, S., Hsu, T., Tan, T., Lyons, J., Zhao, Y., Loebel, D., Wang, Y., Wang, Y., Wang, Y., Cao, Q., Wang, C., Lee, V., Tam, P., Harris, D., et al (2016). a3 Integrin of Cell-Cell Contact Mediates Kidney Fibrosis by Integrin-Linked Kinase in Proximal Tubular E-Cadherin Deficient Mice. American Journal of Pathology, 186(7), 1847-1860. [More Information]
- Pang, M., Wang, H., Rao, P., Zhao, Y., Xie, J., Cao, Q., Wang, Y., Wang, Y., Lee, V., Alexander, S., Harris, D., Zheng, G. (2016). Autophagy links (beta)-catenin and Smad signaling to promote epithelial-mesenchymal transition via upregulation of integrin linked kinase. International Journal of Biochemistry and Cell Biology, 76, 123-134. [More Information]
- Cao, Q., Lu, J., Li, Q., Wang, C., Wang, X., Lee, V., Wang, C., Nguyen, H., Zheng, G., Zhao, Y., Alexander, S., Wang, Y., Harris, D. (2016). CD103+ Dendritic Cells Elicit CD8+ T Cell Responses to Accelerate Kidney Injury in Adriamycin Nephropathy. Journal of the American Society of Nephrology, 278(5), 1344-1360. [More Information]
2015
- Sun, Y., Wang, Y., Cao, Q., Yu, H., Zheng, D., Wang, Y., Harris, D. (2015). Expression and Role of CD166 in the Chronic Kidney Disease. Iranian Journal of Pediatrics, 25(5), 1-8. [More Information]
- Qingsong, H., Niu, Z., Tan, J., Yang, J., Liu, Y., Ma, H., Lee, V., Sun, S., Song, X., Guo, M., Wang, Y., Cao, Q. (2015). IL-25 elicits innate lymphoid cells and multipotent progenitor type 2 cells that reduce renal ischemic/reperfusion injury. Journal of the American Society of Nephrology, 26(9), 2199-2211. [More Information]
- Cao, Q., Harris, D., Wang, Y. (2015). Macrophages in Kidney Injury, Inflammation, and Fibrosis. Physiology, 30(3), 183-194. [More Information]
2014
- Zheng, D., Wen, L., Li, C., Peng, A., Cao, Q., Wang, Y., Harris, D. (2014). Adoptive transfer of bone marrow dendritic cells failed to localize in the renal cortex and to improve renal injury in adriamycin nephropathy. Nephron Experimental Nephrology, 126(1), 8-15. [More Information]
- Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, C., Wang, X., Lee, V., Wang, Y., Wang, Y., Zheng, G., Tan, T., Harris, D., et al (2014). Failed renoprotection by alternatively activated macrophages from bone marrow due to proliferation-dependent phenotype switch in vivo. Kidney International, 85(4), 794-806. [More Information]
- Zhao, Y., Zhao, H., Zhang, Y., Tsatralis, T., Cao, Q., Wang, Y., Wang, Y., Wang, Y., Alexander, S., Harris, D., Zheng, G. (2014). Isolation and epithelial co-culture of mouse renal peritubular endothelial cells. BMC Cell Biology, 15(1), 1-10. [More Information]
2013
- Tian, X., Zhang, J., Tan, T., Lyons, J., Zhao, H., Niu, B., Lee, S., Tsatralis, T., Zhao, Y., Wang, Y., Cao, Q., Wang, C., Wang, Y., Lee, V., Zheng, G., Harris, D., et al (2013). Association of beta catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF- beta1. Journal of Cell Science, 126(1), 67-76. [More Information]
- Wang, C., Yu, X., Cao, Q., Wang, Y., Zheng, G., Tan, T., Zhao, H., Zhao, Y., Wang, Y., Harris, D. (2013). Characterization of murine macrophages from bone marrow, spleen and peritoneum. BMC Immunology, 14(1), 1-10. [More Information]
- Lu, J., Cao, Q., Zheng, D., Sun, Y., Wang, C., Yu, X., Wang, Y., Lee, V., Zheng, G., Tan, T., Wang, X., Harris, D., Wang, Y., et al (2013). Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease. Kidney International, 84(4), 745-755. [More Information]
2012
- Zheng, D., Cao, Q., Lee, V., Wang, Y., Zheng, G., Wang, Y., Tan, T., Wang, C., Alexander, S., Harris, D., Wang, Y. (2012). Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney International, 81(9), 892-902. [More Information]
2011
- Cao, Q., Wang, C., Zheng, D., Wang, Y., Lee, V., Wang, Y., Zheng, G., Tan, T., Yu, D., Alexander, S., Harris, D., Wang, Y. (2011). IL-25 Induces M2 Macrophages and Reduces Renal Injury in Proteinuric Kidney Disease. Journal of the American Society of Nephrology, 22(7), 1229-1239. [More Information]
- Cao, Q., Zheng, D., Wang, Y., Harris, D. (2011). Macrophages and Dendritic Cells for Treating Kidney Disease. Nephron Experimental Nephrology, 117(3), e47-e52. [More Information]
- Lee, V., Cao, Q., Wang, Y., Harris, D. (2011). Role of Macrophages in Renal Injury,Repair and Regeneration. In Michael S. Goligorsky (Eds.), Regenerative Nephrology, (pp. 125-139). USA: Elsevier.
2010
- Cao, Q., Wang, Y., Zheng, D., Sun, Y., Wang, Y., Lee, V., Zheng, G., Tan, T., Ince, J., Alexander, S., Harris, D. (2010). IL-10/TGF-{beta}-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis. Journal of the American Society of Nephrology, 21(6), 933-942. [More Information]
- Tan, T., Zheng, G., Hsu, T., Wang, Y., Lee, V., Tian, X., Wang, Y., Cao, Q., Wang, Y., Harris, D. (2010). Macrophage Matrix Metalloproteinase-9 Mediates Epithelial-Mesenchymal Transition in Vitro in Murine Renal Tubular Cells. American Journal of Pathology, 176(3), 1256-1270. [More Information]
2008
- Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill, T., Cao, Q., Wu, H., Alexander, I., Alexander, S., Harris, D. (2008). Regulatory immune cells in kidney disease. American Journal of Physiology: Renal Physiology, 295(2), F335-F342. [More Information]
Selected Grants
2021
- Developing novel therapeutic approaches by using innate lymphoid cells in chronic kidney disease, Cao Q, National Health and Medical Research Council (NHMRC)/Investigator Grant
2017
- Defining roles of innate lymphoid cells in chronic kidney disease for future therapy, Cao Q, National Health and Medical Research Council (NHMRC)/Project Grants
- Defining the role of kidney CD103Dendritic cells for treatment of chronic kidney disease, Wang Y, Harris D, Wang Y, Cao Q, National Health and Medical Research Council (NHMRC)/Project Grants