Dr Ramin Mostofi Zadeh Farahani
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Dr Ramin Mostofi Zadeh Farahani

DDS, PhD
Lecturer, Department of Life Sciences

Dr Ramin Farahani is a Lecturer at University of Sydney who investigates the role of temporal dimension in adaptiblity of biological systems. Micro-RNAs, in particular, are used as biological tools that access the temporal dimension and communicate novel adaptive signatures. His research currently focuses on the following areas:

  • Reprogramming of ontogeny via temporal dimension
  • The role of miRNAs in reprogramming the temporal dimension
  • The role of miRNAs in buffering genetic noise
  • Evolution of microRNAs and the associated interactome

Dr Farahani’s current research is focused on molecular mechanisms underpinning the adaptive capacity of biological systems with particular emphasis on the role of non-coding DNA and microRNAs. To approach the problem, a combined evo-devo (evolutionary developmental biology) is applied in neurosensory structures.

  • The role of miRNAs in heterochronic regulation of cell fate during ontogeny
  • MiRNA-mediated temporal reprogramming of neoplastic landscape

Publications

Journals

  • Vujovic, F., Shepherd, C., Witting, P., Hunter, N., Mostofi Zadeh Farahani, R. (2023). Redox-Mediated Rewiring of Signalling Pathways: The Role of a Cellular Clock in Brain Health and Disease. Antioxidants, 12(10). [More Information]
  • Vujovic, F., Hunter, N., Mostofi Zadeh Farahani, R. (2022). Cellular self-organization: An overdrive in Cambrian diversity? BioEssays, 44(10). [More Information]
  • Ozsoy, S., Vujovic, F., Simonian, M., Valova, V., Hunter, N., Mostofi Zadeh Farahani, R. (2021). Cannibalized erythroblasts accelerate developmental neurogenesis by regulating mitochondrial dynamics. Cell Reports, 35(1), 108942. [More Information]

2023

  • Vujovic, F., Shepherd, C., Witting, P., Hunter, N., Mostofi Zadeh Farahani, R. (2023). Redox-Mediated Rewiring of Signalling Pathways: The Role of a Cellular Clock in Brain Health and Disease. Antioxidants, 12(10). [More Information]

2022

  • Vujovic, F., Hunter, N., Mostofi Zadeh Farahani, R. (2022). Cellular self-organization: An overdrive in Cambrian diversity? BioEssays, 44(10). [More Information]

2021

  • Ozsoy, S., Vujovic, F., Simonian, M., Valova, V., Hunter, N., Mostofi Zadeh Farahani, R. (2021). Cannibalized erythroblasts accelerate developmental neurogenesis by regulating mitochondrial dynamics. Cell Reports, 35(1), 108942. [More Information]
  • Rezaei-Lotfi, S., Vujovic, F., Simonian, M., Hunter, N., Mostofi Zadeh Farahani, R. (2021). Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes. Genome Biology, 22(1), 334. [More Information]
  • Vujovic, F., Rezaei-Lotfi, S., Hunter, N., Mostofi Zadeh Farahani, R. (2021). The fate of notch-1 transcript is linked to cell cycle dynamics by activity of a natural antisense transcript. Nucleic Acids Research, 49(18), 10419-10430. [More Information]

2020

  • Rezaei‑Lotfi, S., Farahani, R. (2020). Coupled cycling and regulation of metazoan morphogenesis. Cell Division, 15(1), 1. [More Information]
  • Mostofi Zadeh Farahani, R., Rezaei-Lotfi, S., Hunter, N. (2020). Genomic competition for noise reduction shaped evolutionary landscape of mir-4673. Npj Systems Biology And Applications, 6(1), 1-12. [More Information]

2019

  • Rezaei-Lotfi, S., Hunter, N., Mostofi Zadeh Farahani, R. (2019). Beta-Catenin: A Metazoan Filter for Biological Noise? Frontiers in Genetics, 10, 1-9. [More Information]
  • Mostofi Zadeh Farahani, R., Rezaei-Lotfi, S., Simonian, M., Hunter, N. (2019). Bi-modal reprogramming of cell cycle by MiRNA-4673 amplifies human neurogenic capacity. Cell Cycle, 18(8), 848-868. [More Information]
  • Rezaei-Lotfi, S., Hunter, N., Mostofi Zadeh Farahani, R. (2019). Coupled cycling programs multicellular self-organization of neural progenitors. Cell Cycle, 18(17), 2040-2054. [More Information]

2018

  • Sarrafpour, B., Boughton, P., Mostofi Zadeh Farahani, R., Cox, S., Denyer, G., Kelly, E., Zoellner, H. (2018). A method for investigating the cellular response to cyclic tension or compression in three-dimensional culture. Journal of the Mechanical Behavior of Biomedical Materials, 88, 11-17. [More Information]
  • Rathsam, C., Mostofi Zadeh Farahani, R., Hains, P., Valova, V., Charadram, N., Zoellner, H., Swain, M., Hunter, N. (2018). Characterization of inter-crystallite peptides in human enamel rods reveals contribution by the Y allele of amelogenin. Journal of Structural Biology, 204(1), 26-37. [More Information]
  • Dokumcu, K., Simonian, M., Mostofi Zadeh Farahani, R. (2018). miR4673 improves fitness profile of neoplastic cells by induction of autophagy. Cell Death and Disease, 9(11), 1-17. [More Information]

2016

  • Austin, C., Smith, T., Mostofi Zadeh Farahani, R., Hinde, K., Carter, E., Lee, J., Lay, P., Kennedy, B., Sarrafpour, B., Wright, R., Arora, M., et al (2016). Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific Reports, 6, 1-11. [More Information]

2015

  • Farahani, R., Xaymardan, M. (2015). Platelet-Derived Growth Factor Receptor Alpha as a Marker of Mesenchymal Stem Cells in Development and Stem Cell Biology. Stem Cells International, 2015, 1-8. [More Information]

2012

  • Mostofi Zadeh Farahani, R., Sarrafpour, B., Simonian, M., Li, Q., Hunter, N. (2012). Directed glia-assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function. Journal of Comparative Neurology, 520(17), 3803-3826. [More Information]
  • Charadram, N., Mostofi Zadeh Farahani, R., Harty, D., Rathsam, C., Swain, M., Hunter, N. (2012). Regulation of reactionary dentin formation by odontoblasts in response to polymicrobial invasion of dentin matrix. Bone, 50(1), 265-275. [More Information]
  • Harty, D., Mostofi Zadeh Farahani, R., Simonian, M., Hunter, L., Hunter, N. (2012). Streptococcus gordonii FSS2 Challisin affects fibrin clot formation by digestion of the aC region and cleavage of the N-terminal region of the BB chains of fibrinogen. Thrombosis and Haemostasis, 108(2), 236-246. [More Information]

2011

  • Mostofi Zadeh Farahani, R., Simonian, M., Hunter, N. (2011). Blueprint of an Ancestral Neurosensory Organ Revealed in Glial Networks in Human Dental Pulp. Journal of Comparative Neurology, 519(16), 3306-3326. [More Information]
  • Lafzi, A., Chitsazi, M., Mostofi Zadeh Farahani, R., Faramarzi, M. (2011). Comparative clinical study of coronally advanced flap with and without use of plasma rich in growth factors in the treatment of gingival recession. American Journal of Dentistry, 24(3), 143-147.

2010

  • Mostofi Zadeh Farahani, R., Nguyen, K., Simonian, M., Hunter, N. (2010). Adaptive calcified matrix response of dental pulp to bacterial invasion in associated with establishment of a network of Glial Fibrillary Acidic Protein+/Glutamine Synthetase+ Cells. American Journal of Pathology, 177(4), 1901-1914. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Oskouei, S. (2010). Formocresol versus Calcium Hydroxide Direct Pulp Capping of Human Primary Molars: Two Year Follow-Up. Journal of Clinical Pediatric Dentistry, 34(4), 317-321. [More Information]

2009

  • Aminabadi, N., Oskouei, S., Mostofi Zadeh Farahani, R. (2009). Dental Treatment Duration as an Indicator of the Behavior of 3- to 9- Year-old Pediatric Patients in Clinical Dental Settings. The Journal of Contemporary Dental Practice, 10(5), 23-32.
  • Aminabadi, N., Farahani, R., Sohrabi, A., Pouralibaba, F. (2009). Lingual eruption of mandibular permanent incisors: a space correlated phenomenon? The Journal of Contemporary Dental Practice, 10(1), 025-032.
  • Aminabadi, N., Mostofi Zadeh Farahani, R. (2009). The Effect of Pre-cooling the Injection Site on Pediatric Pain Perception during the Administration of Local Anesthesia. The Journal of Contemporary Dental Practice, 10(3), 43-50.

2008

  • Aminabadi, N., Mostofi Zadeh Farahani, R., Gajan, E. (2008). A clinical study of formocresol pulpotomy versus root canal therapy of vital primary incisors. Journal of Clinical Pediatric Dentistry, 32(3), 211-214. [More Information]
  • Aminabadi, N., Mostofi Zadeh Farahani, R., Gajan, E. (2008). Apgar index as a correlate of enamel defects of primary dentition. Oral Health & Preventive Dentistry, 6(4), 331-335. [More Information]
  • Mostofi Zadeh Farahani, R. (2008). Biological mediators of wound healing: the importance of the big picture. International Wound Journal, 5(3), 414-415. [More Information]

Selected Grants

2010

  • Dental pulp microvasculature in reactionary dentinogenesis, Mostofi Zadeh Farahani R, Hunter N, Dental Board of NSW/Research Support

2009

  • The interaction of odontoblasts and dentric pulp cells in healthy and carious human teeth, Mostofi Zadeh Farahani R, Hunter N, Australian Dental Association Inc/Research Support
  • Growth factor expression in reactionary dentinogenesis, Mostofi Zadeh Farahani R, Hunter N, Dental Board of NSW/Research Support