People_

Dr Rebecca San Gil

Lecturer
School of Medical Sciences
Faculty of Medicine and Health

Email

rebecca.sangil@sydney.edu.au

Details

Member of the Charles Perkins Centre

Dr. Rebecca San Gil is a lecturer and group leader in the Neuroscience theme at the School of Medical Sciences, University of Sydney, Australia. She was the inaugural FightMND Early Career Research Fellow and currently leads the NeuroMolecular Discovery Group. Her research focuses on understanding the molecular mechanisms driving neurodegenerative diseases, with a particular emphasis on motor neuron disease (MND) and frontotemporal dementia (FTD), while generating insights that are broadly relevant to other neurodegenerative disorders.

Current projects

PhD and Honours research projects available:

Chaperones in neurobiology, memory, and learning
Harnessing chaperones to protect the brain against protein aggregation and neurodegeneration
Discovery of pharmacological and genetic regulators of the heat shock response in the brain

And many more...

Associations

Australasian Neuroscience Society (Member, 2020-2024 EMCR representative)

International Society for Neurochemistry (Member)

Australian Society for Biochemistry and Molecular Biology (Member)

Themes

Neurosciences and Mental Health, Healthy Ageing

Keywords

Biochemistry, Cell biology, Molecular biology, Motor neuron disease, Neurosciences

Approaches

Cellular/Molecular, Pathogenesis, Translational Research

Publications

By Type

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Journals

San Gil, R., Walker, A. (2025). Unlocking Disease-Modifying Treatments for TDP-43-Mediated Neurodegeneration. BioEssays. [More Information]
San Gil, R., Pascovici, D., Venturato, J., Brown-Wright, H., Mehta, P., Madrid San Martin, L., Wu, J., Luan, W., Chui, Y., Bademosi, A., Lisowski, L., et al (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15(1), 1508. [More Information]
Jacobs, M., San Gil, R., Walker, A. (2024). UndERACting ion channels in neurodegeneration. Trends in Neurosciences, 47(2), 87-89. [More Information]
Keating, S., Bademosi, A., San Gil, R., Walker, A. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cellular and Molecular Life Sciences, 80(4), 95. [More Information]
Luan, W., Wright, A., Brown-Wright, H., Le, S., San Gil, R., Madrid San Martin, L., Ling, K., Jafar-Nejad, P., Rigo, F., Walker, A. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28(6), 2445-2461. [More Information]
Keating, S., San Gil, R., Swanson, M., Scotter, E., Walker, A. (2022). TDP-43 pathology: From noxious assembly to therapeutic removal. Progress in Neurobiology, 211, 102229. [More Information]
San Gil, R., Clarke, B., Ecroyd, H., Kalmar, B., Greensmith, L. (2021). Regional Differences in Heat Shock Protein 25 Expression in Brain and Spinal Cord Astrocytes of Wild-Type and SOD1 G93A Mice. Cells, 101(5), 1257. [More Information]
Wright, A., Della Gatta, P., Le, S., Berning, B., Mehta, P., Jacobs, K., Gul, H., San Gil, R., Hedl, T., Riddell, W., et al (2021). Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience, 54(6), 6237-6255. [More Information]
San Gil, R. (2020). First person – Rebecca San Gil. Journal of Cell Science, 133(15). [More Information]
San Gil, R., Cox, D., Mcalary, L., Berg, T., Walker, A., Yerbury, J., Ooi, L., Ecroyd, H. (2020). Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Journal of Cell Science, 133(15), 1-15. [More Information]
Hedl, T., San Gil, R., Cheng, F., Rayner, S., Davidson, J., De Luca, A., Villalva, M., Ecroyd, H., Walker, A., Lee, A. (2019). Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD. Frontiers in Neuroscience, 13(548), 1-25. [More Information]
Clarke, B., San Gil, R., Yip, J., Kalmar, B., Greensmith, L. (2019). Regional differences in the inflammatory and heat shock response in glia: implications for ALS. Cell Stress and Chaperones, 24(5), 857-870. [More Information]
Cox, D., Whiten, D., Brown, J., Horrocks, M., Gil, R., Dobson, C., Klenerman, D., Van Oijen, A., Ecroyd, H. (2018). The small heat shock protein Hsp27 binds -synuclein fibrils, preventing elongation and cytotoxicity. Journal of Biological Chemistry, 293(12), 4486-4497. [More Information]
San Gil, R., Ooi, L., Yerbury, J., Ecroyd, H. (2017). The heat shock response in neurons and astroglia and its role in neurodegenerative diseases. Molecular Neurodegeneration, 12(1), 65. [More Information]
San Gil, R., Berg, T., Ecroyd, H. (2017). Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells. Scientific Reports, 7(1), 2387. [More Information]
Whiten, D., San Gil, R., Mcalary, L., Yerbury, J., Ecroyd, H., Wilson, M. (2016). Rapid flow cytometric measurement of protein inclusions and nuclear trafficking. Scientific Reports, 6, 31138. [More Information]

show 13 more

By Year

Expand all

2025

San Gil, R., Walker, A. (2025). Unlocking Disease-Modifying Treatments for TDP-43-Mediated Neurodegeneration. BioEssays. [More Information]

2024

San Gil, R., Pascovici, D., Venturato, J., Brown-Wright, H., Mehta, P., Madrid San Martin, L., Wu, J., Luan, W., Chui, Y., Bademosi, A., Lisowski, L., et al (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15(1), 1508. [More Information]
Jacobs, M., San Gil, R., Walker, A. (2024). UndERACting ion channels in neurodegeneration. Trends in Neurosciences, 47(2), 87-89. [More Information]

2023

Keating, S., Bademosi, A., San Gil, R., Walker, A. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cellular and Molecular Life Sciences, 80(4), 95. [More Information]
Luan, W., Wright, A., Brown-Wright, H., Le, S., San Gil, R., Madrid San Martin, L., Ling, K., Jafar-Nejad, P., Rigo, F., Walker, A. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28(6), 2445-2461. [More Information]

2022

Keating, S., San Gil, R., Swanson, M., Scotter, E., Walker, A. (2022). TDP-43 pathology: From noxious assembly to therapeutic removal. Progress in Neurobiology, 211, 102229. [More Information]

2021

San Gil, R., Clarke, B., Ecroyd, H., Kalmar, B., Greensmith, L. (2021). Regional Differences in Heat Shock Protein 25 Expression in Brain and Spinal Cord Astrocytes of Wild-Type and SOD1 G93A Mice. Cells, 101(5), 1257. [More Information]
Wright, A., Della Gatta, P., Le, S., Berning, B., Mehta, P., Jacobs, K., Gul, H., San Gil, R., Hedl, T., Riddell, W., et al (2021). Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience, 54(6), 6237-6255. [More Information]

2020

San Gil, R. (2020). First person – Rebecca San Gil. Journal of Cell Science, 133(15). [More Information]
San Gil, R., Cox, D., Mcalary, L., Berg, T., Walker, A., Yerbury, J., Ooi, L., Ecroyd, H. (2020). Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Journal of Cell Science, 133(15), 1-15. [More Information]

2019

Hedl, T., San Gil, R., Cheng, F., Rayner, S., Davidson, J., De Luca, A., Villalva, M., Ecroyd, H., Walker, A., Lee, A. (2019). Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD. Frontiers in Neuroscience, 13(548), 1-25. [More Information]
Clarke, B., San Gil, R., Yip, J., Kalmar, B., Greensmith, L. (2019). Regional differences in the inflammatory and heat shock response in glia: implications for ALS. Cell Stress and Chaperones, 24(5), 857-870. [More Information]

2018

Cox, D., Whiten, D., Brown, J., Horrocks, M., Gil, R., Dobson, C., Klenerman, D., Van Oijen, A., Ecroyd, H. (2018). The small heat shock protein Hsp27 binds -synuclein fibrils, preventing elongation and cytotoxicity. Journal of Biological Chemistry, 293(12), 4486-4497. [More Information]

2017

San Gil, R., Ooi, L., Yerbury, J., Ecroyd, H. (2017). The heat shock response in neurons and astroglia and its role in neurodegenerative diseases. Molecular Neurodegeneration, 12(1), 65. [More Information]
San Gil, R., Berg, T., Ecroyd, H. (2017). Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells. Scientific Reports, 7(1), 2387. [More Information]

2016

Whiten, D., San Gil, R., Mcalary, L., Yerbury, J., Ecroyd, H., Wilson, M. (2016). Rapid flow cytometric measurement of protein inclusions and nuclear trafficking. Scientific Reports, 6, 31138. [More Information]

Selected Grants

2025