Dr Richard Tan
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Dr Richard Tan

BSc, MEng, PhD
Senior Lecturer
Group Leader of Bio-Informed Engineering
Heart Foundation Postdoctoral Fellow / ARC Early Career Industry Fellow
School of Medical Sciences
Dr Richard Tan

Dr. Richard Tan leads a multidisciplinary bioengineering research group of immunobiologists and engineers in the School of Medical Sciences at the University of Sydney. He completed his Bachelors in Biomedical Engineering program in the U.S at the Georgia Institute of Technology in 2008 earning a Presidential Undergraduate Research Award. He then went on to work for 5 years in Immunology at the Garvan Institute of Medical Research before completing his PhD in Immunomodulatory Biomaterials at the Heart Research Institute in 2019. He has spearheaded a multidisciplinary research effort with leading interventional cardiologist Prof Martin Ng, Royal Prince Alfred Hopsital vascular surgeon Dr. David Robinson, bioengineering scientist/Heart Foundation fellow A/Prof Steven Wise, and industry partner Endoluminal Sciences Pty Ltd. to develop a new endovascular device for the targeted delivery of immunotherapies to treat vascular disease. The quality and translational capacity of his research program is evidenced by recent funding success with the NSW Health EMCR Cardiovascular Research Capacity Scheme, Cardiovascular Initiative, and Juvenile Diabetes Research Foundation.

Localised vascular delivery of immunotherapies

Immunomodulatory biomaterials

Immuno-mechanotransduction

Heart Lung and Circulation Peer Review Fellowship Program (2020)

TERMIS-Australasian Pacific – Best Young Investigator Talk (2019)

Australian Society of Medical Research – Best Poster Presentation Award (2019)

Australia-China Centre for Tissue Engineering and Regenerative Medicine – Best Oral Presentation Award (2018)

Heart Research Institute Student of the Year (2018)

Sydney Cardiovascular Symposium – Rising Star Award – 1st place (2018)

Sydney Cardiovascular Drug Discovery - Young Investigator Award – 1st Place (2018)

Sydney University Dean’s Prize for Student Research Publications Commendation Award (2018)

TERMIS World Congress – Young Investigator Presentation Award – 1st Place (2018)

Heart Research Institute Best Publication Award (2017)

International Society of Heart Research - Best Student Publication Award (2017)

Australian Society of Medical Research – Best Oral Presentation Award (2017)

Heart Research Institute Best Student International Presentation (2016)

Cardiac Society of Australia and New Zealand (ISHR Student Finalist) (2016)

University of Sydney Merit Top-Up Scholarship Award (2015-2018)

Sydney University Australian Post-Graduate Award (APA) Scholarship (2015-2018)

Georgia Institute of Technology Presidential Undergraduate Research Award (2008)

Project titleResearch student
Developing Selective Immunomodulatory Solutions for Cardiovascular DevicesAngus GRANT

Publications

Book Chapters

  • Santos, M., Waterhouse, A., Lee, B., Chan, A., Tan, R., Michael, P., Filipe, E., Hung, J., Wise, S., Bilek, M. (2018). Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings. In Gerard Wall, Halina Podbielska, Magdalena Wawrzynska (Eds.), Functionalized cardiovascular stents, (pp. 211-228). Duxford: Woodhead Publishing Limited. [More Information]
  • Santos, M., Bilek, M., Waterhouse, A., Lee, B., Chan, A., Tan, R., Michael, P., Filipe, E., Hung, J., Wise, S. (2017). Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings. In Gerard Wall, Halina Podbielska, Magdalena Wawrzynska (Eds.), Functionalized cardiovascular stents, (pp. 211-228). Duxford: Woodhead Publishing Limited. [More Information]

Journals

  • Crago, M., Tan, R., Hung, J., Wise, S., Akhavan, B., Bilek, M., Dehghani, F., Talebian, S., Naficy, S. (2024). Durable plasma-mediated zwitterionic grafting on polymeric surfaces for implantable medical devices. Communications Materials, 5(1). [More Information]
  • Correia Dos Santos, M., Michael, P., Mitchell, T., Lam, Y., Robinson, T., Moore, M., Tan, R., Rnjak-Kovacina, J., Lim, K., Wise, S. (2024). On-Demand Bioactivation of Inert Materials With Plasma-Polymerized Nanoparticles. Advanced Materials, , 2311313. [More Information]
  • Lam, Y., Lee, B., Hung, J., Michael, P., Santos, M., Tan, R., Liu, R., Wise, S. (2023). Delivery of Therapeutic miRNA via Plasma-Polymerised Nanoparticles Rescues Diabetes-Impaired Endothelial Function. Nanomaterials, 13(16). [More Information]

2024

  • Crago, M., Tan, R., Hung, J., Wise, S., Akhavan, B., Bilek, M., Dehghani, F., Talebian, S., Naficy, S. (2024). Durable plasma-mediated zwitterionic grafting on polymeric surfaces for implantable medical devices. Communications Materials, 5(1). [More Information]
  • Correia Dos Santos, M., Michael, P., Mitchell, T., Lam, Y., Robinson, T., Moore, M., Tan, R., Rnjak-Kovacina, J., Lim, K., Wise, S. (2024). On-Demand Bioactivation of Inert Materials With Plasma-Polymerized Nanoparticles. Advanced Materials, , 2311313. [More Information]

2023

  • Lam, Y., Lee, B., Hung, J., Michael, P., Santos, M., Tan, R., Liu, R., Wise, S. (2023). Delivery of Therapeutic miRNA via Plasma-Polymerised Nanoparticles Rescues Diabetes-Impaired Endothelial Function. Nanomaterials, 13(16). [More Information]
  • Moore, M., Lam, Y., Santos, M., Tan, R., Yang, N., Hung, J., Li, Z., Kilian, K., Rnjak-Kovacina, J., Pitts, J., Wise, S., et al (2023). Evaluation of the Immune Response to Chitosan-graft-poly(caprolactone) Biopolymer Scaffolds. ACS Biomaterials Science and Engineering, 9(6), 3320-3334. [More Information]
  • Tan, R., Hung, J., Chan, A., Grant, A., Moore, M., Lam, Y., Michael, P., Wise, S. (2023). Highly reproducible rat arterial injury model of neointimal hyperplasia. PloS One, 18(2024-08-08 00:00:00). [More Information]

2022

  • Moore, M., Tan, R., Yang, N., Rnjak-Kovacina, J., Wise, S. (2022). Bioengineering artificial blood vessels from natural materials. Trends in Biotechnology, 40(6), 693-707. [More Information]
  • Lam, Y., Tan, R., Michael, P., Yang, N., Dunn, L., Cooke, J., Celermajer, D., Wise, S., Ng, M. (2022). Endothelial thioredoxin interacting protein (TXNIP) modulates endothelium-dependent vasorelaxation in hyperglycemia. Microvascular research, 143. [More Information]
  • Wei, F., Mu, Y., Tan, R., Wise, S., Bilek, M., Zhou, Y., Xiao, Y. (2022). Osteo-Immunomodulatory Role of Interleukin-4-Immobilized Plasma Immersion Ion Implantation Membranes for Bone Regeneration. ACS Applied Materials and Interfaces. [More Information]

2021

  • Lam, Y., Tan, R., Michael, P., Lau, K., Yang, N., Rnjak-Kovacina, J., Wise, S. (2021). Bioengineering silk into blood vessels. Biochemical Society Transactions, 49(5), 2271-2286. [More Information]
  • Michael, P., Lam, Y., Hung, J., Tan, R., Santos, M., Wise, S. (2021). Comprehensive evaluation of the toxicity and biosafety of plasma polymerized nanoparticles. Nanomaterials, 11(5). [More Information]
  • Tan, R., Ryder, I., Yang, N., Lam, Y., Santos, M., Michael, P., Robinson, D., Ng, M., Wise, S. (2021). Macrophage Polarization as a Novel Therapeutic Target for Endovascular Intervention in Peripheral Artery Disease. JACC: Basic to Translational Science, 6(8), 693-704. [More Information]

2020

  • Croes, M., Akhavan, B., Sharifahmadian, O., Fan, H., Mertens, R., Tan, R., Aliza, C., Fadzil, A., Wise, S., Kruyt, M., Bilek, M., et al (2020). A multifaceted biomimetic interface to improve the longevity of orthopedic implants. Acta Biomaterialia, 110, 266-279. [More Information]
  • Tan, R., Hallahan, N., Kosobrodova, E., Michael, P., Wei, F., Santos, M., Lam, Y., Chan, A., Xiao, Y., Bilek, M., Thorn, P., Wise, S. (2020). Bioactivation of Encapsulation Membranes Reduces Fibrosis and Enhances Cell Survival. ACS Applied Materials and Interfaces, 12(51), 56908-56923. [More Information]
  • Yang, N., Tan, R., Chan, A., Lee, B., Santos, M., Hung, J., Liao, Y., Bilek, M., Fei, J., Wise, S., Bao, B. (2020). Immobilized Macrophage Colony-Stimulating Factor (M-CSF) Regulates the Foreign Body Response to Implanted Materials. ACS Biomaterials Science and Engineering, 6(2), 995-1007. [More Information]

2019

  • Chan, A., Filipe, E., Tan, R., Santos, M., Yang, N., Hung, J., Feng, J., Nazir, S., Benn, A., Ng, M., Wise, S., et al (2019). Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts. Scientific Reports, 9(1), 1-14. [More Information]
  • Tan, R., Chan, A., Wei, S., Santos, M., Lee, B., Filipe, E., Akhavan, B., Bilek, M., Ng, M., Xiao, Y., Wise, S. (2019). Bioactive Materials Facilitating Targeted Local Modulation of Inflammation. JACC: Basic to Translational Science, 4(1), 56-71. [More Information]
  • Santos, M., Reeves, B., Michael, P., Tan, R., Wise, S., Bilek, M. (2019). Substrate geometry modulates self-assembly and collection of plasma polymerized nanoparticles. Communications Physics, 2(1), 1-11. [More Information]

2018

  • Clayton, Z., Tan, R., Miravet, M., Lennartsson, K., Cooke, J., Bursill, C., Wise, S., Patel, S. (2018). Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model. Bioscience Reports, 38(4), 1-11. [More Information]
  • Tan, R., Chan, A., Lennartsson, K., Miravet, M., Lee, B., Rnjak-Kovacina, J., Clayton, Z., Cooke, J., Ng, M., Patel, S., Wise, S. (2018). Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis. Stem Cell Research & Therapy, 9(1), 1-15. [More Information]
  • Santos, M., Michael, P., Filipe, E., Chan, A., Hung, J., Tan, R., Lee, B., Huynh, M., Hawkins, C., Waterhouse, A., Bilek, M., Wise, S. (2018). Plasma synthesis of carbon-based nanocarriers for linker-free immobilization of bioactive cargo. ACS Applied Materials and Interfaces, 1, 580-594. [More Information]

2017

  • Chan, A., Tan, R., Michael, P., Lee, B., Vanags, L., Ng, M., Bursill, C., Wise, S. (2017). Evaluation of synthetic vascular grafts in a mouse carotid grafting model. PloS One, 12(3), 1-15. [More Information]
  • Tan, R., Lee, B., Chan, A., Yuen, S., Hung, J., Wise, S., Ng, M. (2017). Non-invasive tracking of injected bone marrow mononuclear cells to injury and implanted biomaterials. Acta Biomaterialia, 53, 378-388. [More Information]
  • Santos, M., Bilek, M., Waterhouse, A., Lee, B., Chan, A., Tan, R., Michael, P., Filipe, E., Hung, J., Wise, S. (2017). Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings. In Gerard Wall, Halina Podbielska, Magdalena Wawrzynska (Eds.), Functionalized cardiovascular stents, (pp. 211-228). Duxford: Woodhead Publishing Limited. [More Information]

2016

  • Morris, G., Wright, A., Tan, R., Gladbach, A., Ittner, L., Vissel, B. (2016). A comparative study of variables influencing ischemic injury in the longa and koizumi methods of intraluminal filament middle cerebral artery occlusion in mice. PloS One, 11(2), e0148503. [More Information]

2013

  • Wright, A., Zinn, R., Hohensinn, B., Konen, L., Beynon, S., Tan, R., Clark, I., Abdipranoto, A., Vissel, B. (2013). Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer's Disease. PloS One, 8(4). [More Information]

Selected Grants

2024

  • Developing next generation biomaterials for implantable technologies, Tan R, Australian Research Council (ARC)/Early Career Industry Fellowship

2023

  • Revolutionising Heart Valve Replacements with Nanotechnology, Tan R, Wise S, Ng M, National Heart Foundation of Australia/Vanguard Grant
  • A Universal and Scalable Platform Technology to Reduce Calcification and Thrombosis in Cardiovascular Devices, Naficy S, Dehghani F, Tan R, Farajikhah S, Talebian S, NSW Health/Cardiovascular Collaborative Grants

In the media

2019

  1. New Liquid Discovery Could Stop Bodies From Rejecting Medical Implants”, video, ABC Evening News

2018

  1. Richard Tan – CSL Florey Award, AIPS
  2. Heart Patch Helps Stem Cells Work Magic”, Channel 9 Evening News
  3. Richard Tan – Explains His Research on Glowing Stem Cells”, Heart Research Institute Fundraising

2017

  1. Richard Tan Explains How Donations Support His Research”, Heart Research Institute Fundraising
  2. Synthetic Arteries Bypass the Immune System to Mend Broken Hearts”, Australian Society for Medical Research

2016

  1. Glowing Stem Cells Mend Broken Hearts”, The Daily Telegraph
  2. Out with the old and in with the new – Biosynthetic polymers to replace damaged body parts”, Australian Society for Medical Research