Professor Rupert Leong
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Professor Rupert Leong

Clinical Professor
Medicine: Concord Clinical School
Phone
612 97676111
Fax
612 97676767
Professor Rupert Leong

Professor Rupert Leong MBBS, FRACP, MD, AGAF is a Senior Staff Specialist gastroenterologist, Director of Endoscopy and Head of the Inflammatory Bowel Disease Services at Concord Hospital, Professor of Medicine at University of Sydney and Macquarie University, and founding director of IBD Sydney, Australia. He has an international reputation for the management of inflammatory bowel diseases. Prof Leong has made a substantial contribution to research through high quality peer-reviewed scientific journal publications. Amongst these are senior authorship of national and international consensus guidelines in Australia and in the Asia-Pacific region. He serves as the Associate editor of the Therapeutic Advances in Gastroenterology and is on the international editorial boards of Alimentary Pharmacology and Therapeutics, and Gastrointestinal Endoscopy. He is an executive member of a number of government bodies including the Agency for Clinical Innovation of NSW Health nominated for expertise in IBD and the Cancer Council of Australia Working Party on the revision of the clinical practice guidelines for the prevention, early detection and management of colorectal cancer. Professor Leong was awarded the American Gastroenterological Association Fellowship by invitation on the basis of research excellence in 2012 and the UNSW Paper of the Year Prize in 2015.

Gastroenterology

Immunology

Imaging

Endoscopy

Intestinal permeability

Dysplasia, colorectal cancer, surveillance, screening

Quantitative analysis research

Biomarkers, proteomics

Gastroenterology

Inflammatory bowel diseases

2017 Nimmo Lecturership, Adelaide

2016 RACP Trans Tasman Lecturership, NZ Society of Gastroenterology

2015 Emerging Leader GESA

2012 American Gastroenterological Association Fellowship

2011 NHMRC CD Fellow

2011 GESA IBD Award

2010 GESA Career Development Award
2009 ACMA Young Achiever of the Year
2008 GESA Abbott Grant
2007 Cancer Institute of NSW Clinical Fellowship
2007 AGW Poster of Merit x 2
2006 Endeavour Cheung Kong Fellowship
2006 Medical Research Foundation Scholarship: SWSCS
2006 RACP Research Fellowship
2006 UNSW Faculty Research Grant
2005 UNSW Clinical School Tutor of the year prize
2005 UNSW Clinical School Travel Scholarship
2005 Health Research Foundation Sydney South West
2004 AstraZeneca Emerging Leader
2004 UNSW Faculty Research Grant
2003 Culturally and Linguistically Diverse Communities Access Seeding Grant
2002 Australian Gastroenterology Week Poster of Merit
2001 & 2002 Athelstan and Amy Saw Overseas Research Fellowship
2000 Novartis Prize for Young Clinical & Scientific Investigators
1999 GlaxoWellcome Gastroenterology Research Prize

Cancer, Infection and Immunological Conditions

Publications

Journals

  • Pudipeddi, A., Corte, C., Ward, M., De Cruz, P., Lan-San Fung, C., Redmond, D., Chan, W., Mourad, F., Kermeen, M., Leong, R., Paramsothy, S., et al (2024). Effects of Thiopurine Withdrawal on Vedolizumab-Treated Patients With Ulcerative Colitis: A Randomized Controlled Trial. Clinical Gastroenterology and Hepatology. [More Information]
  • Chetwood, J., Tran, Y., Subramanian, S., Smith, P., Iborra, M., Buisson, A., Paramsothy, S., Leong, R. (2024). Intravenous Versus Subcutaneous Infliximab in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Journal of Crohn's and Colitis, 18(9), 1440-1449. [More Information]
  • Chaemsupaphan, T., Leong, R., Vande Casteele, N., Seow, C. (2024). Review article: Optimisation of biologic (monoclonal antibody) therapeutic response in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 60(9), 1234-1243. [More Information]

2024

  • Pudipeddi, A., Corte, C., Ward, M., De Cruz, P., Lan-San Fung, C., Redmond, D., Chan, W., Mourad, F., Kermeen, M., Leong, R., Paramsothy, S., et al (2024). Effects of Thiopurine Withdrawal on Vedolizumab-Treated Patients With Ulcerative Colitis: A Randomized Controlled Trial. Clinical Gastroenterology and Hepatology. [More Information]
  • Chetwood, J., Tran, Y., Subramanian, S., Smith, P., Iborra, M., Buisson, A., Paramsothy, S., Leong, R. (2024). Intravenous Versus Subcutaneous Infliximab in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Journal of Crohn's and Colitis, 18(9), 1440-1449. [More Information]
  • Chaemsupaphan, T., Leong, R., Vande Casteele, N., Seow, C. (2024). Review article: Optimisation of biologic (monoclonal antibody) therapeutic response in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 60(9), 1234-1243. [More Information]

2023

  • Anderson, E., Waller, K., Tamilarasan, A., Lin, H., Paramsothy, S., Leong, R. (2023). Adalimumab originator versus adalimumab biosimilars in inflammatory bowel disease in Australia. Expert Opinion on Biological Therapy. [More Information]
  • Laube, R., Ochieng, A., Seow, C., Christensen, B., Flanagan, E., Kennedy, D., Mountifield, R., Seeho, S., Shand, A., Williams, A., Leong, R. (2023). Australian inflammatory bowel disease consensus statements for preconception, pregnancy and breast feeding. Gut. [More Information]
  • Au, M., Low, P., Rennie, M., Mohseni, M., Song, Y., Kim, N., Baraty, B., Mitrev, N., He, E., Ho, V., Leong, R., et al (2023). Determining efficacy of dynamic multimedia bowel preparation instructions versus standard instructions on adenoma detection and patient reported measures (DIGICLEAN trial): A study protocol for a multicentre, colonoscopist-blinded, randomised controlled trial. BMJ Open, 13(7). [More Information]

2022

  • Waller, K., Leong, R., Paramsothy, S. (2022). An update on fecal microbiota transplantation for the treatment of gastrointestinal diseases. Journal of Gastroenterology and Hepatology, 37(2), 246-255. [More Information]
  • Pudipeddi, A., Paramsothy, S., Leong, R. (2022). Combination Therapy of Immunomodulators With Non-Anti-Tumor Necrosis Factor Agents in Inflammatory Bowel Disease: Need More Evidence? Clinical Gastroenterology and Hepatology, 20(3), e640-e641. [More Information]
  • Ma, C., Hanzel, J., Panaccione, R., Sandborn, W., D'Haens, G., Ahuja, V., Atreya, R., Bernstein, C., Bossuyt, P., Bressler, B., Leong, R., et al (2022). CORE-IBD: A Multidisciplinary International Consensus Initiative to Develop a Core Outcome Set for Randomized Controlled Trials in Inflammatory Bowel Disease. Gastroenterology. [More Information]

2021

  • Laube, R., Tran, Y., Paramsothy, S., Leong, R. (2021). Assisted Reproductive Technology in Crohn's Disease and Ulcerative Colitis: A Systematic Review and Meta-Analysis. American Journal of Gastroenterology, 116(12), 2334-2344. [More Information]
  • Williams, A., Paramsothy, R., Wu, N., Ghaly, S., Leach, S., Paramsothy, S., Corte, C., O'Brien, C., Burke, C., Wark, G., et al (2021). Australia IBD Microbiome (AIM) Study: protocol for a multicentre longitudinal prospective cohort study. BMJ Open, 11(2), e042493. [More Information]
  • Aluzaite, K., Greveson, K., Ben-Horin, S., Leong, R., Haj, O., Schultz, M. (2021). Barriers to international travel in inflammatory bowel disease patients. Journal of Travel Medicine, 28(1), 1-8. [More Information]

2020

  • Haifer, C., Kelly, C., Paramsothy, S., Andresen, D., Papanicolas, L., McKew, G., Borody, T., Kamm, M., Costello, S., Andrews, J., van der Poorten, D., Leong, R., et al (2020). Australian consensus statements for the regulation, production and use of faecal microbiota transplantation in clinical practice. Gut, 69(5), 801-810. [More Information]
  • Haifer, C., Paramsothy, S., Leong, R. (2020). Faecal microbiota transplantation as an elixir of youth. Hepatobiliary Surgery and Nutrition, 9(4), 488-489. [More Information]
  • Chan, W., Kariyawasam, V., Kim, S., Pudipeddi, A., Paramsothy, S., Shim, H., Mourad, F., Ding, N., Ferrante, M., Leong, R. (2020). Gastroenterologists' preference and risk perception on the use of immunomodulators and biological therapies in elderly patients with ulcerative colitis: an international survey. European Journal of Gastroenterology and Hepatology, 32, 976-983. [More Information]

2019

  • Wehrhahn, M., Keighley, C., Kurtovic, J., Knight, D., Hong, S., Hutton, M., Lyras, D., Wang, Q., Leong, R., Borody, T., et al (2019). A series of three cases of severe Clostridium difficile infection in Australia associated with a binary toxin producing clade 2 ribotype 251 strain. Anaerobe, 55, 117-123. [More Information]
  • Kariyawasam, V., Kim, S., Mourad, F., Selinger, C., Katelaris, P., Jones, B., McDonald, C., Barr, G., Chapman, G., Colliwshaw, J., Lunney, P., Middleton, K., Huang, T., et al (2019). Comorbidities Rather Than Age Are Associated With the Use of Immunomodulators in Elderly-onset Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(8), 1390-1398. [More Information]
  • Selvaratnam, S., Gullino, S., Shim, L., Lee, E., Lee, A., Paramsothy, S., Leong, R. (2019). Epidemiology of inflammatory bowel disease in South America: A systematic review. World Journal of Gastroenterology, 25(47), 6866-6875. [More Information]

2018

  • Chan, W., Shim, H., Ng, S., Liu, J., Inglis, C., Greveson, K., Baraty, B., Haifer, C., Leong, R. (2018). A Global Survey of Gastroenterologists' Travel Advice to Patients with Inflammatory Bowel Disease on Immunosuppressive Agents and Management of Those Visiting Tuberculosis-Endemic Areas. Journal of Crohn's and Colitis, 12(11), 1261-1269. [More Information]
  • Danese, S., Banerjee, R., Cummings, J., Dotan, I., Kotze, P., Leong, R., Paridaens, K., Peyrin-Biroulet, L., Scott, G., van Assche, G., et al (2018). Consensus recommendations for patient-centered therapy in mild-to-moderate ulcerative colitis: the i Support Therapy-Access to Rapid Treatment (iSTART) approach. Intestinal Research, 16(4), 522-528. [More Information]
  • Chan, W., Mourad, F., Leong, R. (2018). Crohn's disease associated strictures. Journal of Gastroenterology and Hepatology, 33(5), 998-1008. [More Information]

2017

  • Sanagapalli, S., Agnihotri, K., Leong, R., Corte, C. (2017). Antispasmodic drugs in colonoscopy: a review of their pharmacology, safety and efficacy in improving polyp detection and related outcomes. Therapeutic Advances in Gastroenterology, 10(1), 101-113. [More Information]
  • van der List, E., Chen, A., Leong, R., Whiteley, I., Rickard, M., Chapman, G., Katelaris, P., McDonald, C., Kwok, A., Lee, C., Kariyawasam, V., et al (2017). Disability in Surgical Inflammatory Bowel Disease Patients. Clinical Gastroenterology and Hepatology, 15(1), 157-158. [More Information]
  • Mitrev, N., Kariyawasam, V., Leong, R. (2017). Editorial: infliximab trough cut-off for perianal Crohn's disease - another piece of the therapeutic drug monitoring-guided infliximab dosing puzzle. Alimentary Pharmacology and Therapeutics, 45(9), 1279-1280. [More Information]

2016

  • Chiu, H., Ching, J., Wu, K., Rerknimitr, R., Li, J., Wu, D., Goh, K., Matsuda, T., Kim, H., Leong, R., et al (2016). A Risk-Scoring System Combined with a Fecal Immunochemical Test Is Effective in Screening High-Risk Subjects for Early Colonoscopy to Detect Advanced Colorectal Neoplasms. Gastroenterology, 150(3), 617-625. [More Information]
  • Ooi, C., Makharia, G., Hilmi, I., Gibson, P., Fock, K., Ahuja, V., Ling, K., Lim, W., Thia, K., Leong, R., et al (2016). Asia Pacific Consensus Statements on Crohn's disease. Part 1: Definition, diagnosis, and epidemiology: (Asia Pacific Crohn's Disease Consensus-Part 1). Journal of Gastroenterology and Hepatology, 31(1), 45-55. [More Information]
  • Ooi, C., Makharia, G., Hilmi, I., Gibson, P., Fock, K., Ahuja, V., Ling, K., Lim, W., Thia, K., Leong, R., et al (2016). Asia-Pacific consensus statements on Crohn's disease. Part 2: Management. Journal of Gastroenterology and Hepatology, 31(1), 56-68. [More Information]

2015

  • Paramsothy, S., Borody, T., Lin, E., Finlayson, S., Walsh, A., Samuel, D., Van Den Bogaerde, J., Leong, R., Connor, S., Ng, W., et al (2015). Donor recruitment for fecal microbiota transplantation. Inflammatory Bowel Diseases, 21(7), 1600-1606. [More Information]
  • Moran, N., Webster, B., Lee, K., Trotman, J., Kwan, Y., Napoli, J., Leong, R. (2015). Epstein Barr virus-positive mucocutaneous ulcer of the colon associated Hodgkin lymphoma in Crohn's disease. World Journal of Gastroenterology, 21(19), 6072-6076. [More Information]
  • Paramsothy, S., Walsh, A., Borody, T., Samuel, D., Van Den Bogaerde, J., Leong, R., Connor, S., Ng, W., Mitchell, H., Kaakoush, N., et al (2015). Gastroenterologist perceptions of faecal microbiota transplantation. World Journal of Gastroenterology, 21(38), 10907-10914. [More Information]

2014

  • Kariyawasam, V., Selinger, C., Katelaris, P., Jones, B., McDonald, C., Barr, G., Chapman, G., Colliwshaw, J., Lunney, P., Middleton, K., Wang, R., et al (2014). Early Use of Thiopurines or Methotrexate Reduces Major Abdominal and Perianal Surgery in Crohn's Disease. Inflammatory Bowel Diseases, 20(8), 1382-1390. [More Information]
  • Selinger, C., Andrews, J., Titman, A., Norton, I., Jones, D., McDonald, C., Barr, G., Selby, W., Leong, R. (2014). Long-term follow up reveals low incidence of colorectal cancer, but frequent need for resection, among Australian patients with inflammatory bowel disease. Clinical Gastroenterology and Hepatology, 12(4), 644-650. [More Information]
  • Lee, C., Hsu, P., Nanan, B., Nanan, R., Wong, M., Gaskin, K., Leong, R., Murchie, R., Muise, A., Stormon, M. (2014). Novel de novo mutations of the interleukin-10 receptor gene lead to infantile onset inflammatory bowel disease. Journal of Crohn's and Colitis, 8(11), 1551-1556. [More Information]

2013

  • Selinger, C., Lal, S., Eaden, J., Jones, B., Katelaris, P., Chapman, G., McDonald, C., Leong, R., McLaughlin, J. (2013). Better disease specific patient knowledge is associated with greater anxiety in inflammatory bowel disease. Journal of Crohn's and Colitis, 7(6), e214-e218. [More Information]
  • Selinger, C., Andrews, J., Dent, O., Norton, I., Jones, B., McDonald, C., Cowlishaw, J., Barr, G., Selby, W., Leong, R. (2013). Cause-Specific Mortality and 30-year Relative Survival of Crohn's Disease and Ulcerative Colitis. Inflammatory Bowel Diseases, 19(9), 1880-1888. [More Information]
  • Selinger, C., Kinjo, Y., Jones, B., Katelaris, P., Chapman, G., McDonald, C., Lal, S., McLaughlin, J., Robinson, A., Leong, R. (2013). Conveying medication benefits to ulcerative colitis patients and effects on patient attitudes regarding thresholds for adherence. Journal of Crohn's and Colitis, 7(8), e312-e317. [More Information]

2012

  • Selinger, C., Eaden, J., Selby, W., Jones, B., Katelaris, P., Chapman, G., McDonald, C., McLaughlin, J., Leong, R., Lal, S. (2012). Patients' knowledge of pregnancy-related issues in inflammatory bowel disease and validation of a novel assessment tool ('CCPKnow'). Alimentary Pharmacology and Therapeutics, 36(1), 57-63. [More Information]
  • Lunney, P., Leong, R. (2012). Review article: Ulcerative colitis, smoking and nicotine therapy. Alimentary Pharmacology and Therapeutics, 36(11-12), 997-1008. [More Information]
  • Corte, C., Saxena, P., Tattersall, S., Selinger, C., Leong, R. (2012). When to Use Biological Agents in Inflammatory Bowel Disease. Journal of Gastroenterology and Hepatology, 27(7), 1141-1149. [More Information]

2010

  • Fanning, S., Kwok, A., Jones, B., Leong, R. (2010). EUS aspiration needle size: smaller is better? Gastrointestinal Endoscopy, 72(4), 904-905. [More Information]
  • Koo, J., Arasaratnam, M., Liu, K., Redmond, D., Connor, S., Sung, J., Leong, R. (2010). Knowledge, perception and practices of colorectal cancer screening in an ethnically diverse population. Cancer Epidemiology, 34(5), 604-610. [More Information]

2009

  • Sharifian, A., Humphris, J., Leong, R., Jones, D. (2009). Education and imaging. Gastrointestinal: Mycobacterium genavense enteritis in an immunosuppressed patient. Journal of Gastroenterology and Hepatology, 24(8), 1474. [More Information]
  • Chang, D., Johns, A., Merrett, N., Gill, A., Colvin, E., Scarlett, C., Nguyen, N., Leong, R., Cosman, P., Kelly, M., Kench, J., et al (2009). Margin Clearance and Outcome in Resected Pancreatic Cancer. Journal of Clinical Oncology, 27(17), 2855-2862. [More Information]
  • Nguyen, N., Biankin, A., Leong, R., Chang, D., Cosman, P., Delaney, P., Kench, J., Merrett, N. (2009). Real time intraoperative confocal laser microscopy-guided surgery. Annals of Surgery, 249(5), 735-737. [More Information]

2008

  • Kwok, A., Lam, T., Katelaris, P., Leong, R. (2008). Helicobacter pylori eradication therapy: indications, efficacy and safety. Expert Opinion on Drug Safety, 7(3), 271-281. [More Information]
  • Leong, R., Nguyen, N., MEREDITH, C., AL–SOHAILY, S., KUKIC, D., Delaney, P., MURR, E., Yong, J., Merrett, N., Biankin, A. (2008). In vivo confocal endomicroscopy in the diagnosis and evaluation of celiac disease. Gastroenterology, 135(6), 1870-1876. [More Information]

Selected Grants

2019

  • Lyophilised Orally Administered Faecal Microbiota Transplantation in the Management of Ulcerative Colitis LOTUS Study - a Double-Blind Randomised Controlled Trial, Leong R, Gutsy Group Inc/Research Grant

In the media

Channel 9

https://www.9now.com.au/today/2018/clip-cjo69ogio000h0gmw4929stis

ABC Catalyst

https://tv.press.abc.net.au/gut-revolution-a-catalyst-special

http://www.abc.net.au/tv/programs/catalyst/transcripts/GUT_Pt2_Transcript.pdf