Dr Sonia Yip
People_

Dr Sonia Yip

Oncology Translational Research Fellow
NHMRC Clinical Trials Centre, Sydney Medical School
Phone
+61 2 9562 5345
Fax
+61 2 9562 5094

Dr Sonia Yip is a Senior Research Fellow and the Translational Research Lead of Oncology at the CTC. She has high level input into the design and development of translational research studies of investigator-initiated clinical trials in oncology. She leads the Translational Research team in the implementation of these studies.

Sonia obtained her PhD in molecular biology in signal transduction pathways in breast cancer and CML (Garvan Institute and placement at Dana Farber Cancer Institute, Harvard). She has over 10+ years’ experience in the oncology clinical trials (PhI-III) and translational research in public health, academia and industry in the UK & Australia. She established and managed the SE London Cancer Research Network of the National Cancer Research Network (NCRN) and a Preclinical and Translational Research Group at a multinational pharmaceutical company.

Sonia currently collaborates with national cancer co-operative trials groups and research laboratories to develop biomarker studies of trials in solid tumours.

Sonia co-leads the national translational research study, AUTO-CHECK across multiple tumour types looking at molecular determinants of immune related adverse events. She is a project team member for the Cancer Australia-funded Genomics Cancer Clinical Trials Initiative (GCCTI)

Sonia is a faculty member of the Master of Clinical Trials - Biomarkers module, at the University of Sydney and is course co-ordinator.

Cancer

Publications

Journals

  • Tan, L., Brown, C., Mersiades, T., Lee, C., John, T., Kao, S., Newnham, G., O'Byrne, K., Parakh, S., Bray, V., Yip, S., Clarke, S., Pavlakis, N., Stockler, M., et al (2024). A Phase II trial of alternating osimertinib and gefitinib therapy in advanced EGFR-T790M positive non-small cell lung cancer: OSCILLATE. Nature Communications, 15(1). [More Information]
  • Mersiades, T., Solomon, B., Thomas, D., Lee, C., Parry, M., Sebastian, L., Ballinger, M., Collignon, E., Turnbull, O., Yip, S., Morton, R., Brown, C., Itchins, M., Simes, R., Pavlakis, N., et al (2024). ASPiRATION: Australian observational cohort study of comprehensive genomic profiling in metastatic lung cancer tissue. Future Oncology, 20(7), 361-371. [More Information]
  • Werner, B., Sjoquist, K., Espinoza, D., Yip, S., Chang, G., Parry, M., Mileshkin, L., Ananda, S., Shannon, C., Friedlander, M., et al (2024). Cell-free DNA in plasma and ascites as a biomarker of bevacizumab response- a translational research sub-study of the REZOLVE (ANZGOG-1101) clinical trial. Translational Oncology, 43. [More Information]

Conferences

  • Yip, S. (2011). Translational research and personalised medicine. The Australian New Zealand Gynaecological Oncology Group (ANZGOG) ASM.

2024

  • Tan, L., Brown, C., Mersiades, T., Lee, C., John, T., Kao, S., Newnham, G., O'Byrne, K., Parakh, S., Bray, V., Yip, S., Clarke, S., Pavlakis, N., Stockler, M., et al (2024). A Phase II trial of alternating osimertinib and gefitinib therapy in advanced EGFR-T790M positive non-small cell lung cancer: OSCILLATE. Nature Communications, 15(1). [More Information]
  • Mersiades, T., Solomon, B., Thomas, D., Lee, C., Parry, M., Sebastian, L., Ballinger, M., Collignon, E., Turnbull, O., Yip, S., Morton, R., Brown, C., Itchins, M., Simes, R., Pavlakis, N., et al (2024). ASPiRATION: Australian observational cohort study of comprehensive genomic profiling in metastatic lung cancer tissue. Future Oncology, 20(7), 361-371. [More Information]
  • Werner, B., Sjoquist, K., Espinoza, D., Yip, S., Chang, G., Parry, M., Mileshkin, L., Ananda, S., Shannon, C., Friedlander, M., et al (2024). Cell-free DNA in plasma and ascites as a biomarker of bevacizumab response- a translational research sub-study of the REZOLVE (ANZGOG-1101) clinical trial. Translational Oncology, 43. [More Information]

2023

  • Hao, Y., Miraghazadeh, B., Chand, R., Davies, A., Cardinez, C., Kwong, K., Downes, M., Sweet, R., Cañete, P., D’Orsogna, L., Yip, S., et al (2023). CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells. Cellular & Molecular Immunology, 20(7), 777-793. [More Information]
  • Lam, L., Pavlakis, N., Shitara, K., Sjoquist, K., Martin, A., Yip, S., Kang, Y., Bang, Y., Chen, L., Moehler, M., Hague, W., Gebski, V., Jaworski, A., Simes, R., et al (2023). INTEGRATE II: randomised phase III controlled trials of regorafenib containing regimens versus standard of care in refractory Advanced Gastro-Oesophageal Cancer (AGOC): a study by the Australasian Gastro-Intestinal Trials Group (AGITG). BMC Cancer, 23(1). [More Information]
  • Sim, H., Wachsmuth, L., Barnes, E., Yip, S., Koh, E., Hall, M., Jennens, R., Kong, B., Simes, R., Khasraw, M., et al (2023). NUTMEG: A randomized phase II study of nivolumab and temozolomide versus temozolomide alone in newly diagnosed older patients with glioblastoma. Neuro-Oncology Advances, 5(1), vdad124. [More Information]

2022

  • Stockler, M., Martin, A., Davis, I., Dhillon, H., Begbie, S., Chi, K., Chowdhury, S., Coskinas, X., Frydenberg, M., Hague, W., Winter, D., Yip, S., et al (2022). Health-Related Quality of Life in Metastatic, Hormone-Sensitive Prostate Cancer: ENZAMET (ANZUP 1304), an International, Randomized Phase III Trial Led by ANZUP. Journal of Clinical Oncology, 40(8), 837-846. [More Information]
  • Kong, B., Sim, H., Barnes, E., Nowak, A., Hovey, E., Jeffree, R., Harrup, R., Parkinson, J., Gan, H., Pinkham, M., Yip, S., Hall, M., Tu, E., Carter, C., Simes, R., et al (2022). Multi-Arm GlioblastoMa Australasia (MAGMA): Protocol for a multiarm randomised clinical trial for people affected by glioblastoma. BMJ Open, 12(9). [More Information]
  • Kok, P., Forde, P., Hughes, B., Sun, Z., Brown, C., Ramalingam, S., Cook, A., Lesterhuis, W., Yip, S., O'Byrne, K., Pavlakis, N., Ford, K., Parry, M., Stockler, M., et al (2022). Protocol of DREAM3R: DuRvalumab with chEmotherapy as first-line treAtment in advanced pleural Mesothelioma-a phase 3 randomised trial. BMJ Open, 12(1), e057663-1-e057663-8. [More Information]

2021

  • Mitchell, P., O'Byrne, K., Stockler, M., Yip, S., nhmrWalker, M., Balasubramaniam, S., Ab Rahman, A., Kok, P., Jurkovic, H., Brown, C., et al (2021). A Randomized Phase 2 Trial of Nivolumab and Stereotactic Ablative Body Radiotherapy (SABR) in Advanced Non-Small Cell Lung Cancer, Progressing After First- or Second-Line Chemotherapy (NIVORAD). International Journal of Radiation Oncology Biology Physics, 111(3), S10-S11. [More Information]
  • Sim, H., McDonald, K., Lwin, Z., Barnes, E., Rosenthal, M., Foote, M., Koh, E., Back, M., Wheeler, H., Sulman, E., Buckland, M., Fisher, L., Leonard, R., Hall, M., Yip, S., Simes, R., Khasraw, M., et al (2021). A randomized phase II trial of veliparib, radiotherapy, and temozolomide in patients with unmethylated MGMT glioblastoma: The VERTU study. Neuro-Oncology, 23(10), 1736-1749. [More Information]
  • Oar, A., Lee, M., Le, H., Wilson, K., Aiken, C., Chantrill, L., Simes, R., Nguyen, N., Barbour, A., Samra, J., Sjoquist, K., Espinoza, D., Gebski, V., Yip, S., Kneebone, A., Goldstein, D., et al (2021). AGITG MASTERPLAN: a randomised phase II study of modified FOLFIRINOX alone or in combination with stereotactic body radiotherapy for patients with high-risk and locally advanced pancreatic cancer. BMC Cancer, 21(1), 936. [More Information]

2020

  • Nowak, A., Lesterhuis, W., Kok, P., Brown, C., Hughes, B., Karikios, D., John, T., Kao, S., Leslie, C., Cook, A., Langford, A., Yip, S., Stockler, M., et al (2020). Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-in. The Lancet Oncology, 21(9), 1213-1223. [More Information]

2019

  • Yip, S., Fleming, J., Shepherd, H., Walczak, A., Clark, J., Butow, P. (2019). "As Long as You Ask": A Qualitative Study of Biobanking Consent-Oncology Patients' and Health Care Professionals' Attitudes, Motivations, and Experiences-the B-PPAE Study. The Oncologist, 24(6), 844-856. [More Information]
  • Tang, M., Joensuu, H., Simes, R., Price, T., Yip, S., Hague, W., Sjoquist, K., Zalcberg, J. (2019). Challenges of international oncology trial collaboration-a call to action. British Journal of Cancer, 121(7), 515-521. [More Information]
  • Davis, I., Martin, A., Stockler, M., Begbie, S., Chi, K., Chowdhury, S., Coskinas, X., Frydenberg, M., Hague, W., Horvath, L., Marx, G., Tu, E., Yip, S., Zhang, A., et al (2019). Enzalutamide with standard first-line therapy in metastatic prostate cancer. New England Journal of Medicine, 381(2), 121-131. [More Information]

2018

  • Lawrence, N., Chan, H., Toner, G., Stockler, M., Martin, A., Yip, S., Wong, N., Yeung, A., Mazhar, D., Pashankar, F., et al (2018). Protocol for the P3BEP trial (ANZUP 1302): An international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours. BMC Cancer, 18(1), 1-6. [More Information]

2016

  • Pavlakis, N., Sjoquist, K., Martin, A., Tsobanis, E., Yip, S., Kang, Y., Bang, Y., Alcindor, T., O'Callaghan, C., Burnell, M., Wong, K., Simes, R., et al (2016). Regorafenib for the treatment of advanced gastric cancer (INTEGRATE): A multinational placebo-controlled phase II Trial. Journal of Clinical Oncology, 34(23), 2728-2735. [More Information]

2015

  • Davis, I., Long, A., Yip, S., Espinoza, D., Thompson, J., Kichenadasse, G., Harrision, M., Lowenthal, R., Pavlakis, N., Azad, A., Hudson, A., Stockler, M., Martin, A., et al (2015). EVERSUN: A phase 2 trial of alternating sunitinib and everolimus as first line therapy for advanced renal cell carcinoma. Annals of Oncology, 26(6), 1118-1123. [More Information]
  • Chantrill, L., Nagrial, A., Watson, C., Johns, A., Martyn-Smith, M., Simpson, S., Mead, S., Jones, M., Samra, J., Gill, A., Chin, V., Sebastian, L., Sjoquist, K., Yip, S., Pavlakis, N., Grimison, P., Simes, R., et al (2015). Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial. Clinical Cancer Research, 21(9), 2029-2037. [More Information]

2011

  • Clarke, S., Yip, S., Brown, C., van Hazel, G., Ransom, D., Goldstein, D., Jeffrey, G., Tebbutt, N., Buck, M., Lowenthal, R., Boland, A., Gebski, V., Simes, R., et al (2011). Single-agent irinotecan or 5-fluorouracil and leucovorin (FOLFIRI) as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis. European Journal of Cancer, 47(12), 1826-1836. [More Information]
  • Yip, S. (2011). Translational research and personalised medicine. The Australian New Zealand Gynaecological Oncology Group (ANZGOG) ASM.

2010

  • Karapetis, C., Cheong, K., Yip, D., Strickland, A., Steer, C., Marx, G., Yip, S., Chrystal, K., Harper, P. (2010). A phase I and II trial of epirubicin, cisplatin, 24-hour infusion 5 fluorouracil and sodium folinate in patients with advanced esophagogastric carcinomas. Asia-Pacific Journal of Clinical Oncology, 6(4), 289-305. [More Information]

Selected Grants

2022

  • LUMOS: Low and Anaplastic Grade Glioma Umbrella Study of Molecular Guided TherapieS, Gan H, Simes R, Sim H, Yip S, Thavaneswaran S, Department of Health and Aged Care (Federal)/MRFF - Rare Cancers, Rare Diseases and Unmet Need (RCRDUN)

2020

  • The IWOT study: can we wait to treat lower grade glioma, Pinkham M, Yip S, Mark Hughes Foundation Ltd/Australian Brain Cancer Mission