People_

Professor Steven Wise

Professor of Cardiovascular Bioengineering
School of Medical Sciences

Phone

+612 8627 9458

Email

steven.wise@sydney.edu.au

Details

Member of The University of Sydney Nano Institute

Member of the Charles Perkins Centre

Biographical details

Professor Steven Wise is a Heart Foundation Future Leader Fellow and Leader of the Applied Materials Group at the School of Medical Sciences at the University of Sydney. He completed a Bachelor of Science (Hons 1, University Medal, UWS 2001) followed by a PhD studying tropoelastin assembly and function with Prof Anthony Weiss (2006) at the University of Sydney. As a postdoc he trained with Interventional Cardiologist Prof Martin Ng, contributing to the founding of an interdisciplinary program to develop platform biomaterials for cardiovascular applications. Working in multi-disciplinary research teams he has specialised in materials engineering, blood compatibility and interactions with endothelial and smooth muscle cells. A strength of his group is their comprehensive range of pre-clinical models for evaluation of new materials and vascular devices. His recent funding success, including NHMRC project, NHMRC development and ARC Linkage demonstrate the quality of his research program and aligns with its goals of developing implants to improve patient lives. His project to develop new synthetic conduits for arterial revascularisation received the NHMRC Marshall and Warren award for 2018.

Themes

Obesity, Diabetes and Cardiovascular Disease

Keywords

Biochemistry, Cardiovascular diseases, Regeneration medicine/Tissue engineering, Thrombosis

Approaches

Animal Models, Translational Research

Current research students

Project title	Research student
Construction of a 3D In Vitro Blood-Brain Barrier Model Reinforced with Silk Protein and Its Application in Developing Drugs for Blood-Brain Barrier Penetration	Yanhao Dong DONG
Developing Selective Immunomodulatory Solutions for Cardiovascular Devices	Angus GRANT
Smart Tissue Adhesive Hydrogels for Regenerative Medicine Applications	Minh Ho HO
3D printed nanomaterials scaffolds for wound healing	Yiwei LI
Hydrogels for large scale 3D stem cell culture and harvest	Renjian TAN

Publications

By Type

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Book Chapters

Santos, M., Waterhouse, A., Lee, B., Chan, A., Tan, R., Michael, P., Filipe, E., Hung, J., Wise, S., Bilek, M. (2018). Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings. In Gerard Wall, Halina Podbielska, Magdalena Wawrzynska (Eds.), Functionalized cardiovascular stents, (pp. 211-228). Duxford: Woodhead Publishing Limited. [More Information]
Santos, M., Bilek, M., Waterhouse, A., Lee, B., Chan, A., Tan, R., Michael, P., Filipe, E., Hung, J., Wise, S. (2017). Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings. In Gerard Wall, Halina Podbielska, Magdalena Wawrzynska (Eds.), Functionalized cardiovascular stents, (pp. 211-228). Duxford: Woodhead Publishing Limited. [More Information]

Journals

Major, G., Joukhdar, H., Choi, Y., Rnjak-Kovacina, J., Wise, S., Ju, A., Cox, T., Xu, C., Yeo, G., Young, J., Lim, K. (2025). Photochemistry as a tool for dynamic modulation of hydrogel mechanics. Cell Reports Physical Science, 6(1). [More Information]
Crago, M., Tan, R., Hung, J., Wise, S., Akhavan, B., Bilek, M., Dehghani, F., Talebian, S., Naficy, S. (2024). Durable plasma-mediated zwitterionic grafting on polymeric surfaces for implantable medical devices. Communications Materials, 5(1). [More Information]
Vuong, T., Bartolf-Kopp, M., Andelovic, K., Jungst, T., Farbehi, N., Wise, S., Hayward, C., Stevens, M., Rnjak-Kovacina, J. (2024). Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries. Advanced Science, 11(26). [More Information]
Major, G., Doan, V., Longoni, A., Bilek, M., Wise, S., Rnjak-Kovacina, J., Yeo, G., Lim, K. (2024). Mapping the microcarrier design pathway to modernise clinical mesenchymal stromal cell expansion (In Press). Trends in Biotechnology. [More Information]
Ho, T., Tran, H., Vinh Khanh, D., Maitz, J., Li, Z., Wise, S., Lim, K., Rnjak-Kovacina, J. (2024). Natural Polymer-Based Materials for Wound Healing Applications. Advanced NanoBiomed Research, , 2300131. [More Information]
Correia Dos Santos, M., Michael, P., Mitchell, T., Lam, Y., Robinson, T., Moore, M., Tan, R., Rnjak-Kovacina, J., Lim, K., Wise, S. (2024). On-Demand Bioactivation of Inert Materials With Plasma-Polymerized Nanoparticles. Advanced Materials, , 2311313. [More Information]
Tran, H., Maraldo, A., Ho, T., Thai, M., Van Hilst, Q., Joukhdar, H., Kordanovski, M., Sahoo, J., Hartsuk, O., Correia Dos Santos, M., Lim, K., Wise, S. (2024). Probing the Interplay of Protein Self-Assembly and Covalent Bond Formation in Photo-Crosslinked Silk Fibroin Hydrogels (In Press). Small. [More Information]
Major, G., Ahn, M., Cho, W., Santos, M., Wise, J., Phillips, E., Wise, S., Jang, J., Rnjak-Kovacina, J., Woodfield, T., Lim, K. (2024). Programming temporal stiffness cues within extracellular matrix hydrogels for modelling cancer niches. Materials Today Bio, 25. [More Information]
Jiang, S., Wise, S., Kovacic, J., Rnjak, J., Lord, M. (2023). Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts. Trends in Biotechnology. [More Information]
Lam, Y., Lee, B., Hung, J., Michael, P., Santos, M., Tan, R., Liu, R., Wise, S. (2023). Delivery of Therapeutic miRNA via Plasma-Polymerised Nanoparticles Rescues Diabetes-Impaired Endothelial Function. Nanomaterials, 13(16). [More Information]
Mitchell, T., Feng, N., Lam, M., Michael, P., Correia Dos Santos, M., Wise, S. (2023). Engineering Vascular Bioreactor Systems to Closely Mimic Physiological Forces In Vitro. Tissue Engineering. Part B. Reviews, 29(3), 232-243. [More Information]
Moore, M., Lam, Y., Santos, M., Tan, R., Yang, N., Hung, J., Li, Z., Kilian, K., Rnjak-Kovacina, J., Pitts, J., Wise, S., et al (2023). Evaluation of the Immune Response to Chitosan-graft-poly(caprolactone) Biopolymer Scaffolds. ACS Biomaterials Science and Engineering, 9(6), 3320-3334. [More Information]
Ho, M., Van Hilst, Q., Cui, X., Ramaswamy, Y., Woodfield, T., Rnjak-Kovacina, J., Wise, S., Lim, K. (2023). From Adhesion to Detachment: Strategies to Design Tissue-Adhesive Hydrogels. Advanced NanoBiomed Research. [More Information]
Tan, R., Hung, J., Chan, A., Grant, A., Moore, M., Lam, Y., Michael, P., Wise, S. (2023). Highly reproducible rat arterial injury model of neointimal hyperplasia. PloS One, 18(2024-08-08 00:00:00). [More Information]
Grant, A., Yang, N., Moore, M., Lam, Y., Michael, P., Chan, A., Santos, M., Rnjak-Kovacina, J., Tan, R., Wise, S. (2023). Selective NLRP3 Inflammasome Inhibitor MCC950 Suppresses Inflammation and Facilitates Healing in Vascular Materials. Advanced Science, 10(20). [More Information]
Chapman, N., Thomas, E., Tan, J., Inglis, S., Wu, J., Climie, R., Picone, D., Blekkenhorst, L., Wise, S., Mirabito Colafella, K., et al (2022). A roadmap of strategies to support cardiovascular researchers: from policy to practice. Nature Reviews Cardiology, 19(11), 765-777. [More Information]
Moore, M., Tan, R., Yang, N., Rnjak-Kovacina, J., Wise, S. (2022). Bioengineering artificial blood vessels from natural materials. Trends in Biotechnology, 40(6), 693-707. [More Information]
Liu, Q., Zhang, J., Xia, L., Wise, S., Hambly, B., Tao, K., Bao, S. (2022). Clinical implications of interleukins-31, 32, and 33 in gastric cancer. World Journal of Gastrointestinal Oncology, 14(9), 1808-1822. [More Information]
Lau, K., Heu, C., Moore, M., Zhang, A., Akhavan, B., Wise, S., Bilek, M., Lord, M., Rnjak-Kovacina, J. (2022). Effect of plasma ion immersion implantation on physiochemical and biological properties of silk towards creating a versatile biomaterial platform. Materials Today Advances, 13, 100212. [More Information]
Lam, Y., Tan, R., Michael, P., Yang, N., Dunn, L., Cooke, J., Celermajer, D., Wise, S., Ng, M. (2022). Endothelial thioredoxin interacting protein (TXNIP) modulates endothelium-dependent vasorelaxation in hyperglycemia. Microvascular research, 143. [More Information]
Wei, F., Mu, Y., Tan, R., Wise, S., Bilek, M., Zhou, Y., Xiao, Y. (2022). Osteo-Immunomodulatory Role of Interleukin-4-Immobilized Plasma Immersion Ion Implantation Membranes for Bone Regeneration. ACS Applied Materials and Interfaces. [More Information]
Michael, P., Yang, N., Moore, M., Santos, M., Lam, Y., Ward, A., Hung, J., Tan, R., Wise, S. (2022). Synthetic Vascular Graft with Spatially Distinct Architecture for Rapid Biomimetic Cell Organisation in a Perfusion Bioreactor. Biomedical Materials, 17(4), 45001. [More Information]
Lee, B., Yang, N., Santos, M., Moore, M., Grant, A., Jang, J., Akhavan, B., Bilek, M., Tan, R., Wise, S. (2022). Truncated vascular endothelial cadherin enhances rapid endothelialization of small diameter synthetic vascular grafts. Materials Today Advances, 14, 100222. [More Information]
Lam, Y., Tan, R., Michael, P., Lau, K., Yang, N., Rnjak-Kovacina, J., Wise, S. (2021). Bioengineering silk into blood vessels. Biochemical Society Transactions, 49(5), 2271-2286. [More Information]
Michael, P., Lam, Y., Hung, J., Tan, R., Santos, M., Wise, S. (2021). Comprehensive evaluation of the toxicity and biosafety of plasma polymerized nanoparticles. Nanomaterials, 11(5). [More Information]
Tan, R., Ryder, I., Yang, N., Lam, Y., Santos, M., Michael, P., Robinson, D., Ng, M., Wise, S. (2021). Macrophage Polarization as a Novel Therapeutic Target for Endovascular Intervention in Peripheral Artery Disease. JACC: Basic to Translational Science, 6(8), 693-704. [More Information]
Sharifahmadian, O., Zhai, C., Hung, J., Shineh, G., Stewart, C., Ionescu, M., Fadzil, A., Gan, Y., Wise, S., Akhavan, B. (2021). Mechanically robust nitrogen-rich plasma polymers: Biofunctional interfaces for surface engineering of biomedical implants. Materials Today Advances, 12, 100188. [More Information]
Besnier, M., Finemore, M., Yu, C., Kott, K., Vernon, S., Seebacher, N., Genetzakis, E., Furman, A., Tang, O., Davis, R., Hansen, T., Bubb, K., Wise, S., Grieve, S., Di Bartolo, B., Figtree, G., et al (2021). Patient endothelial colony-forming cells to model coronary artery disease susceptibility and unravel the role of dysregulated mitochondrial redox signalling. Antioxidants, 10(10), 1547. [More Information]
Jaure, A., Sorrell, T., Black, A., Caillaud, C., Chrzanowski, W., Li, E., Martinez-Martin, D., McEwan, A., Wang, R., Motion, A., Casas Bedoya, A., Huang, J., Azizi, L., Eggleton, B., Andersen, T., Baillie, A., Barratt, A., Boehm, C., Britton, P., Chadban, S., Chow, C., Fleming, S., Fox, G., Gordon, L., Baillie, A., Howell, M., Hickie, I., Hunt, N., Iredell, J., Jin, C., Kairaitis, K., Kavehei, O., Kritharides, L., Leon-Saval, S., Lindley, R., Maguire, S., McCluskey, M., McKay, N., Mifsud, G., Palomba, S., Pettigrew, A., Postnova, S., Prinable, J., Rabeau, J., Rees, M., Richmond, K., Scholes-Robertson, N., Seppelt, I., Shaw, T., Sintchenko, V., Snelling, T., Teixeira-Pinto, A., Tovey, E., Tuniz, A., Varamini, P., Wang, A., Wang, K., Wise, S., Zoellner, H., et al (2021). Research priorities for COVID-19 sensor technology. Nature Biotechnology, 39(2), 144-153. [More Information]
Yang, N., Moore, M., Michael, P., Santos, M., Lam, Y., Bao, S., Ng, M., Rnjak-Kovacina, J., Tan, R., Wise, S. (2021). Silk Fibroin Scaffold Architecture Regulates Inflammatory Responses and Engraftment of Bone Marrow-Mononuclear Cells. Advanced Healthcare Materials, 10(16), 2100615. [More Information]
Croes, M., Akhavan, B., Sharifahmadian, O., Fan, H., Mertens, R., Tan, R., Aliza, C., Fadzil, A., Wise, S., Kruyt, M., Bilek, M., et al (2020). A multifaceted biomimetic interface to improve the longevity of orthopedic implants. Acta Biomaterialia, 110, 266-279. [More Information]
Lam, M., Hsu, C., Simpson, P., Dunn, L., Chow, R., Chan, K., Yong, A., Yu, Y., Sieveking, D., Lecce (Venuto), L., Celermajer, D., Wise, S., Ng, M., et al (2020). Androgens Stimulate EPC-Mediated Neovascularization and Are Associated with Increased Coronary Collateralization. Endocrinology, 161(5), 1-13. [More Information]
Tan, R., Hallahan, N., Kosobrodova, E., Michael, P., Wei, F., Santos, M., Lam, Y., Chan, A., Xiao, Y., Bilek, M., Thorn, P., Wise, S. (2020). Bioactivation of Encapsulation Membranes Reduces Fibrosis and Enhances Cell Survival. ACS Applied Materials and Interfaces, 12(51), 56908-56923. [More Information]
Yang, N., Tan, R., Chan, A., Lee, B., Santos, M., Hung, J., Liao, Y., Bilek, M., Fei, J., Wise, S., Bao, B. (2020). Immobilized Macrophage Colony-Stimulating Factor (M-CSF) Regulates the Foreign Body Response to Implanted Materials. ACS Biomaterials Science and Engineering, 6(2), 995-1007. [More Information]
Climie, R., Wu, J., Calkin, A., Chapman, N., Inglis, S., Mirabito Colafella, K., Picone, D., Tan, J., Thomas, E., Viola, H., Wise, S., Figtree, G., et al (2020). Lack of Strategic Funding and Long-Term Job Security Threaten to Have Profound Effects on Cardiovascular Researcher Retention in Australia. Heart, Lung, and Circulation, 29, 1588-1595. [More Information]
Michael, P., Lam, Y., Filipe, E., Tan, R., Chan, A., Lee, B., Feng, N., Hung, J., Cox, T., Santos, M., Wise, S. (2020). Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo. Scientific Reports, 10(1), 1-14. [More Information]
Cui, X., Soliman, B., Alcala-Orozco, C., Li, J., Vis, M., Santos, M., Wise, S., Levato, R., Malda, J., Woodfield, T., et al (2020). Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity. Advanced Healthcare Materials, 9(4), 1901667. [More Information]
Stewart, C., Akhavan, B., Wise, S., Bilek, M. (2019). A review of biomimetic surface functionalization for bone-integrating orthopedic implants: Mechanisms, current approaches, and future directions. Progress in Materials Science, 106, 1-40. [More Information]
Chan, A., Filipe, E., Tan, R., Santos, M., Yang, N., Hung, J., Feng, J., Nazir, S., Benn, A., Ng, M., Wise, S., et al (2019). Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts. Scientific Reports, 9(1), 1-14. [More Information]
Lam, M., Lecce (Venuto), L., Yuen, S., Wise, S., Handelsman, D., Karas, R., Ng, M. (2019). Androgens Ameliorate Impaired Ischemia-Induced Neovascularization due to Aging in Male Mice. Endocrinology, 160(5), 1137-1149. [More Information]
Tan, R., Chan, A., Wei, S., Santos, M., Lee, B., Filipe, E., Akhavan, B., Bilek, M., Ng, M., Xiao, Y., Wise, S. (2019). Bioactive Materials Facilitating Targeted Local Modulation of Inflammation. JACC: Basic to Translational Science, 4(1), 56-71. [More Information]
Naficy, S., Le, T., Oveissi, F., Lee, A., Hung, J., Wise, S., Winlaw, D., Dehghani, F. (2019). Highly Porous, Biocompatible Tough Hydrogels, Processable via Gel Fiber Spinning and 3D Gel Printing. Advanced Materials Interfaces, 7(3), 1-10. [More Information]
Akhavan, B., Croes, M., Wise, S., Zhai, C., Hung, J., Stewart, C., Ionescu, M., Weinans, H., Gan, Y., Yavari, S., Bilek, M. (2019). Radical-functionalized plasma polymers: Stable biomimetic interfaces for bone implant applications. Applied Materials Today, 16, 456-473. [More Information]
Biglari, S., Le, T., Tan, R., Wise, S., Zambon, A., Codolo, G., De Bernard, M., Warkiani, M., Schindeler, A., Naficy, S., Valtchev, P., Dehghani, F., et al (2019). Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model. Advanced Healthcare Materials, 8(1), 1-12. [More Information]
Santos, M., Reeves, B., Michael, P., Tan, R., Wise, S., Bilek, M. (2019). Substrate geometry modulates self-assembly and collection of plasma polymerized nanoparticles. Communications Physics, 2(1), 1-11. [More Information]
Kulkarni, K., Hung, J., Fulcher, A., Chan, A., Hong, A., Forsythe, J., Aguilar, M., Wise, S., Del Borgo, M. (2018). β3-Tripeptides Coassemble into Fluorescent Hydrogels for Serial Monitoring in Vivo. ACS Biomaterials Science and Engineering, 4(11), 3843-3847. [More Information]
Lam, M., Lecce (Venuto), L., Yuen, G., Wise, S., Handelsman, D., Ng, M. (2018). Androgen action augments ischemia-induced, bone marrow progenitor cell-mediated vasculogenesis. International Journal of Biological Sciences, 14(14), 1985-1992. [More Information]
Vanags, L., Tan, J., Galougahi, K., Schaefer, A., Wise, S., Murphy, A., Ali, Z., Bursill, C. (2018). Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype. JACC: Basic to Translational Science, 3(2), 200-209. [More Information]
Stewart, C., Akhavan, B., Santos, M., Hung, J., Hawkins, C., Bao, B., Wise, S., Bilek, M. (2018). Cellular responses to radical propagation from ion-implanted plasma polymer surfaces. Applied Surface Science, 456, 701-710. [More Information]
Degendorfer, G., Chuang, C., Mariotti, M., Hammer, A., Hoefler, G., Hagglund, P., Malle, E., Wise, S., Davies, M. (2018). Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function. Free Radical Biology and Medicine, 115, 219-231. [More Information]
Clayton, Z., Tan, R., Miravet, M., Lennartsson, K., Cooke, J., Bursill, C., Wise, S., Patel, S. (2018). Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model. Bioscience Reports, 38(4), 1-11. [More Information]
Tan, R., Chan, A., Lennartsson, K., Miravet, M., Lee, B., Rnjak-Kovacina, J., Clayton, Z., Cooke, J., Ng, M., Patel, S., Wise, S. (2018). Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis. Stem Cell Research & Therapy, 9(1), 1-15. [More Information]
Stewart, C., Akhavan, B., Hung, J., Bao, B., Jang, J., Wise, S., Bilek, M. (2018). Multifunctional Protein-Immobilized Plasma Polymer Films for Orthopedic Applications. ACS Biomaterials Science and Engineering, 4(12), 4084-4094. [More Information]
Akhavan, B., Michl, T., Giles, C., Ho, K., Martin, L., Sharifahmadian, O., Wise, S., Coad, B., Kumar, N., Griesser, H., Bilek, M. (2018). Plasma activated coatings with dual action against fungi and bacteria. Applied Materials Today, 12, 72-84. [More Information]
Santos, M., Michael, P., Filipe, E., Chan, A., Hung, J., Tan, R., Lee, B., Huynh, M., Hawkins, C., Waterhouse, A., Bilek, M., Wise, S. (2018). Plasma synthesis of carbon-based nanocarriers for linker-free immobilization of bioactive cargo. ACS Applied Materials and Interfaces, 1, 580-594. [More Information]
Filipe, E., Santos, M., Hung, J., Lee, B., Yang, N., Chan, A., Ng, M., Rnjak-Kovacina, J., Wise, S. (2018). Rapid Endothelialization of Off-the-Shelf Small Diameter Silk Vascular Grafts. JACC: Basic to Translational Science, 3(1), 38-53. [More Information]
Tan, R., Chan, A., Santos, M., Filipe, E., Akhavan, B., Lee, B., Bilek, M., Wise, S., Ng, M. (2017). A Novel Bioactive Interleukin-4 Functionalised Vascular Graft That Modulates Inflammation and Inhibits Neointimal Hyperplasia. Heart, Lung, and Circulation, 26, S279-S279. [More Information]
Wise, S., Santos, M., Michael, P., Lee, B., Hung, J., Weiss, A., Bilek, M., Ng, M. (2017). A Novel Recombinant Human Tropoelastin-Functionalised Stent Platform for Suppression of Restenosis in Peripheral Vascular Disease. Heart, Lung, and Circulation, 26, S197-S198. [More Information]
Chan, A., Tan, R., Michael, P., Lee, B., Vanags, L., Ng, M., Bursill, C., Wise, S. (2017). Evaluation of synthetic vascular grafts in a mouse carotid grafting model. PloS One, 12(3), 1-15. [More Information]
Tan, R., Lee, B., Chan, A., Yuen, S., Hung, J., Wise, S., Ng, M. (2017). Non-invasive tracking of injected bone marrow mononuclear cells to injury and implanted biomaterials. Acta Biomaterialia, 53, 378-388. [More Information]
Vanags, L., Tan, J., Santos, M., Michael, P., Ali, Z., Bilek, M., Wise, S., Bursill, C. (2017). Plasma activated coating immobilizes apolipoprotein A-I to stainless steel surfaces in its bioactive form and enhances biocompatibility. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(7), 2141-2150. [More Information]
Kondyurina, I., Wise, S., Ngo, A., Filipe, E., Kondyurin, A., Weiss, A., Bao, B., Bilek, M. (2017). Plasma mediated protein immobilisation enhances the vascular compatibility of polyurethane with tissue matched mechanical properties. Biomedical Materials, 12(4), 1-14. [More Information]
Yeo, G., Baldock, C., Wise, S., Weiss, A. (2017). Targeted Modulation of Tropoelastin Structure and Assembly. ACS Biomaterials Science and Engineering, 3(11), 2832-2844. [More Information]
Wise, S., Liu, H., Yeo, G., Michael, P., Chan, A., Ngo, A., Bilek, M., Bao, B., Weiss, A. (2016). Blended Polyurethane and Tropoelastin as a Novel Class of Biologically Interactive Elastomer. Tissue Engineering - Part A, 22(5-6), 524-533. [More Information]
Santos, M., Filipe, E., Michael, P., Hung, J., Wise, S., Bilek, M. (2016). Mechanically Robust Plasma-Activated Interfaces Optimized for Vascular Stent Applications. ACS Applied Materials and Interfaces, 8(15), 9635-9650. [More Information]
Wise, S., Liu, H., Kondyurin, A., Byrom, M., Bannon, P., Edwards, G., Weiss, A., Bao, B., Bilek, M. (2016). Plasma Ion Activated Expanded Polytetrafluoroethylene Vascular Grafts with a Covalently Immobilized Recombinant Human Tropoelastin Coating Reducing Neointimal Hyperplasia. ACS Biomaterials Science and Engineering, 2(8), 1286-1297. [More Information]
Akhavan, B., Wise, S., Bilek, M. (2016). Substrate-Regulated Growth of Plasma-Polymerized Films on Carbide-Forming Metals. Langmuir, 32(42), 10835-10843. [More Information]
Yeo, G., Tarakanova, A., Baldock, C., Wise, S., Buehler, M., Weiss, A. (2016). Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly. Science Advances, 2(2), 1-14. [More Information]
Hiob, M., Trane, A., Wise, S., Bernatchez, P., Weiss, A. (2016). Tropoelastin enhances nitric oxide production by endothelial cells. Nanomedicine, 11(12), 1591-1597. [More Information]
Wakelin, E., Kondyurin, A., Wise, S., McKenzie, D., Davies, M., Bilek, M. (2015). Bio-Activation of Polyether Ether Ketone Using Plasma Immersion Ion Implantation: A Kinetic Model. Plasma Processes and Polymers, 12(2), 180-193. [More Information]
Yu, Y., Wise, S., Celermajer, D., Bilek, M., Ng, M. (2015). Bioengineering stents with proactive biocompatibility. Interventional Cardiology, 7(6), 571-584. [More Information]
Yu, Y., Wise, S., Michael, P., Bax, D., Yuen, G., Hiob, M., Yeo, G., Filipe, E., Dunn, L., Chan, K., Mollahajian, H., Celermajer, D., Weiss, A., Ng, M. (2015). Characterization of Endothelial Progenitor Cell Interactions with Human Tropoelastin. PloS One, 10(6), 1-16. [More Information]
Wise, S., Michael, P., Waterhouse, A., Santos, M., Filipe, E., Hung, J., Kondyurin, A., Bilek, M., Ng, M. (2015). Immobilization of bioactive plasmin reduces the thrombogenicity of metal surfaces. Colloids And Surfaces B: Biointerfaces, 136, 944-954. [More Information]
Wakelin, E., Fathi, A., Kracica, M., Yeo, G., Wise, S., Weiss, A., McCulloch, D., Dehghani, F., McKenzie, D., Bilek, M. (2015). Mechanical Properties of Plasma Immersion Ion Implanted PEEK for Bioactivation of Medical Devices. ACS Applied Materials and Interfaces, 7(41), 23029-23040. [More Information]
Yeo, G., Baldock, C., Wise, S., Weiss, A. (2014). A Negatively Charged Residue Stabilizes the Tropoelastin N-terminal Region for Elastic Fiber Assembly. Journal of Biological Chemistry, 289(50), 34815-34826. [More Information]
Jeewandara, T., Wise, S., Ng, M. (2014). Biocompatibility of Coronary Stents. Materials, 7(2), 769-786. [More Information]
Liu, H., Wise, S., Rnjak-Kovacina, J., Kaplan, D., Bilek, M., Weiss, A., Fei, J., Bao, B. (2014). Biocompatibility of silk-tropoelastin protein polymers. Biomaterials, 35(19), 5138-5147. [More Information]
Hajian, H., Wise, S., Bax, D., Kondyurin, A., Waterhouse, A., Dunn, L., Kielty, C., Yu, Y., Weiss, A., Bilek, M., Bannon, P., et al (2014). Immobilisation of a fibrillin-1 fragment enhances the biocompatibility of PTFE. Colloids And Surfaces B: Biointerfaces, 116, 544-552. [More Information]
Wise, S., Yeo, G., Hiob, M., Rnjak-Kovacina, J., Kaplan, D., Ng, M., Weiss, A. (2014). Tropoelastin: A versatile, bioactive assembly module. Acta Biomaterialia, 10(4), 1532-1541. [More Information]
Saitow, C., Wise, S., Weiss, A., Castellot Jr, J., Kaplan, D. (2013). Elastin biology and tissue engineering with adult cells. Biomolecular Concepts, 4(2), 173-185. [More Information]
Almine, J., Wise, S., Hiob, M., Singh, N., Tiwari, K., Vali, S., Abbasi, T., Weiss, A. (2013). Elastin sequences trigger transient proinflammatory responses by human dermal fibroblasts. The FASEB Journal, 27(9), 3455-3465. [More Information]
Hiob, M., Wise, S., Kondyurin, A., Waterhouse, A., Bilek, M., Ng, M., Weiss, A. (2013). The use of plasma-activated covalent attachment of early domains of tropoelastin to enhance vascular compatibility of surfaces. Biomaterials, 34(31), 7584-7591. [More Information]
Mithieux, S., Wise, S., Weiss, A. (2013). Tropoelastin - A multifaceted naturally smart material. Advanced Drug Delivery Reviews, 65(4), 421-428. [More Information]
Almine, J., Wise, S., Weiss, A. (2012). Elastin Signaling in Wound Repair. Birth Defects Research. Part C: Embryo Today Reviews, 96(3), 248-257. [More Information]
Rnjak-Kovacina, J., Wise, S., Li, Z., Maitz, P., Young, C., Wang, Y., Weiss, A. (2012). Electrospun synthetic human elastin: collagen composite scaffolds for dermal tissue engineering. Acta Biomaterialia, 8(10), 3714-3722. [More Information]
Wise, S., Waterhouse, A., Michael, P., Ng, M. (2012). Extracellular matrix molecules facilitating vascular biointegration. Journal of Functional Biomaterials, 3(3), 569-587. [More Information]
Waterhouse, A., Wise, S., Yin, Y., Wu, B., James, B., Zreiqat, H., McKenzie, D., Bao, B., Weiss, A., Ng, M., Bilek, M. (2012). In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomaterials, 33(32), 7984-7992. [More Information]
Wise, S., Waterhouse, A., Kondyurin, A., Bilek, M., Weiss, A. (2012). Plasma-based biofunctionalization of vascular implants. Nanomedicine, 7(12), 1907-1916. [More Information]
Ohgo, K., Niemczura, W., Seacat, B., Wise, S., Weiss, A., Kumashiro, K. (2012). Resolving Nitrogen-15 and Proton Chemical Shifts for Mobile Segments of Elastin with Two-dimensional NMR Spectroscopy. Journal of Biological Chemistry, 287(22), 18201-18209. [More Information]
Yeo, G., Baldock, C., Tuukkanen, A., Roessle, M., Dyksterhuis, L., Wise, S., Matthews, J., Mithieux, S., Weiss, A. (2012). Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly. Proceedings of the National Academy of Sciences of the United States of America, 109(8), 2878-2883. [More Information]
Wise, S., Byrom, M., Waterhouse, A., Bannon, P., Ng, M., Weiss, A. (2011). A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties. Acta Biomaterialia, 7(1), 295-303. [More Information]
Waterhouse, A., Wise, S., Ng, M., Weiss, A. (2011). Elastin as a Nonthrombogenic Biomaterial. Tissue Engineering. Part B. Reviews, 17(2), 93-99. [More Information]
Rnjak-Kovacina, J., Wise, S., Mithieux, S., Weiss, A. (2011). Severe burn injuries and the role of elastin in the design of dermal substitutes. Tissue Engineering. Part B. Reviews, 17(2), 81-91. [More Information]
Waterhouse, A., Bax, D., Wise, S., Yin, Y., Dunn, L., Yeo, G., Ng, M., Bilek, M., Weiss, A. (2011). Stability of a Therapeutic Layer of Immobilized Recombinant Human Tropoelastin on a Plasma-Activated Coated Surface. Pharmaceutical Research, 28(6), 1415-1421. [More Information]
Rnjak-Kovacina, J., Wise, S., Li, Z., Maitz, P., Young, C., Wang, Y., Weiss, A. (2011). Tailoring the porosity and pore size of electrospun synthetic human elastin scaffolds for dermal tissue engineering. Biomaterials, 32(28), 6729-6736. [More Information]
Almine, J., Bax, D., Mithieux, S., Nivison-Smith, L., Rnjak-Kovacina, J., Waterhouse, A., Wise, S., Weiss, A. (2010). Elastin-based materials. Chemical Society Reviews, 39(9), 3371-3379. [More Information]
Tu, Y., Wise, S., Weiss, A. (2010). Stages in tropoelastin coalescence during synthetic elastin hydrogel formation. Micron, 41(3), 268-272. [More Information]
Waterhouse, A., Yin, Y., Wise, S., Bax, D., McKenzie, D., Bilek, M., Weiss, A., Ng, M. (2010). The immobilization of recombinant human tropoelastin on metals using a plasma-activated coating to improve the biocompatibility of coronary stents. Biomaterials, 31(32), 8332-8340. [More Information]
Yin, Y., Wise, S., Nosworthy, N., Waterhouse, A., Bax, D., Youssef, H., Byrom, M., Bilek, M., McKenzie, D., Weiss, A., Ng, M. (2009). Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces. Biomaterials, 30(9), 1675-1681. [More Information]
Wise, S., Mithieux, S., Weiss, A. (2009). Engineered tropoelastin and elastin-based biomaterials. Advances in Protein Chemistry and Structural Biology.
Rnjak-Kovacina, J., Li, Z., Maitz, P., Wise, S., Weiss, A. (2009). Primary human dermal fibroblast interactions with open weave three-dimensional scaffolds prepared from synthetic human elastin. Biomaterials, 30(32), 6469-6477. [More Information]
Wise, S., Weiss, A. (2009). Tropoelastin. International Journal of Biochemistry and Cell Biology, 41(3), 494-497. [More Information]
Mithieux, S., Wise, S., Raftery, M., Starcher, B., Weiss, A. (2005). A model two-component system for studying the architecture of elastin assembly in vitro. Journal of Structural Biology, 149(3), 282-289. [More Information]
Clarke, A., Wise, S., Cain, S., Kielty, C., Weiss, A. (2005). Coacervation is promoted by molecular interactions between the PF2 segment of fibrillin-1 and the domain 4 region of tropoelastin. Biochemistry. [More Information]
Wise, S., Mithieux, S., Raftery, M., Weiss, A. (2005). Specificity in the coacervation of tropoelastin: solvent exposed lysines. Journal of Structural Biology, 149(3), 273-281. [More Information]

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Patents

Ng, M., Weiss, A., Wise, S. (2008). Patent No. WO2008/037028. USA, Europe, Australia.

By Year

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2025

Major, G., Joukhdar, H., Choi, Y., Rnjak-Kovacina, J., Wise, S., Ju, A., Cox, T., Xu, C., Yeo, G., Young, J., Lim, K. (2025). Photochemistry as a tool for dynamic modulation of hydrogel mechanics. Cell Reports Physical Science, 6(1). [More Information]

2024

Crago, M., Tan, R., Hung, J., Wise, S., Akhavan, B., Bilek, M., Dehghani, F., Talebian, S., Naficy, S. (2024). Durable plasma-mediated zwitterionic grafting on polymeric surfaces for implantable medical devices. Communications Materials, 5(1). [More Information]
Vuong, T., Bartolf-Kopp, M., Andelovic, K., Jungst, T., Farbehi, N., Wise, S., Hayward, C., Stevens, M., Rnjak-Kovacina, J. (2024). Integrating Computational and Biological Hemodynamic Approaches to Improve Modeling of Atherosclerotic Arteries. Advanced Science, 11(26). [More Information]
Major, G., Doan, V., Longoni, A., Bilek, M., Wise, S., Rnjak-Kovacina, J., Yeo, G., Lim, K. (2024). Mapping the microcarrier design pathway to modernise clinical mesenchymal stromal cell expansion (In Press). Trends in Biotechnology. [More Information]
Ho, T., Tran, H., Vinh Khanh, D., Maitz, J., Li, Z., Wise, S., Lim, K., Rnjak-Kovacina, J. (2024). Natural Polymer-Based Materials for Wound Healing Applications. Advanced NanoBiomed Research, , 2300131. [More Information]
Correia Dos Santos, M., Michael, P., Mitchell, T., Lam, Y., Robinson, T., Moore, M., Tan, R., Rnjak-Kovacina, J., Lim, K., Wise, S. (2024). On-Demand Bioactivation of Inert Materials With Plasma-Polymerized Nanoparticles. Advanced Materials, , 2311313. [More Information]
Tran, H., Maraldo, A., Ho, T., Thai, M., Van Hilst, Q., Joukhdar, H., Kordanovski, M., Sahoo, J., Hartsuk, O., Correia Dos Santos, M., Lim, K., Wise, S. (2024). Probing the Interplay of Protein Self-Assembly and Covalent Bond Formation in Photo-Crosslinked Silk Fibroin Hydrogels (In Press). Small. [More Information]
Major, G., Ahn, M., Cho, W., Santos, M., Wise, J., Phillips, E., Wise, S., Jang, J., Rnjak-Kovacina, J., Woodfield, T., Lim, K. (2024). Programming temporal stiffness cues within extracellular matrix hydrogels for modelling cancer niches. Materials Today Bio, 25. [More Information]

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2023

Jiang, S., Wise, S., Kovacic, J., Rnjak, J., Lord, M. (2023). Biomaterials containing extracellular matrix molecules as biomimetic next-generation vascular grafts. Trends in Biotechnology. [More Information]
Lam, Y., Lee, B., Hung, J., Michael, P., Santos, M., Tan, R., Liu, R., Wise, S. (2023). Delivery of Therapeutic miRNA via Plasma-Polymerised Nanoparticles Rescues Diabetes-Impaired Endothelial Function. Nanomaterials, 13(16). [More Information]
Mitchell, T., Feng, N., Lam, M., Michael, P., Correia Dos Santos, M., Wise, S. (2023). Engineering Vascular Bioreactor Systems to Closely Mimic Physiological Forces In Vitro. Tissue Engineering. Part B. Reviews, 29(3), 232-243. [More Information]
Moore, M., Lam, Y., Santos, M., Tan, R., Yang, N., Hung, J., Li, Z., Kilian, K., Rnjak-Kovacina, J., Pitts, J., Wise, S., et al (2023). Evaluation of the Immune Response to Chitosan-graft-poly(caprolactone) Biopolymer Scaffolds. ACS Biomaterials Science and Engineering, 9(6), 3320-3334. [More Information]
Ho, M., Van Hilst, Q., Cui, X., Ramaswamy, Y., Woodfield, T., Rnjak-Kovacina, J., Wise, S., Lim, K. (2023). From Adhesion to Detachment: Strategies to Design Tissue-Adhesive Hydrogels. Advanced NanoBiomed Research. [More Information]
Tan, R., Hung, J., Chan, A., Grant, A., Moore, M., Lam, Y., Michael, P., Wise, S. (2023). Highly reproducible rat arterial injury model of neointimal hyperplasia. PloS One, 18(2024-08-08 00:00:00). [More Information]
Grant, A., Yang, N., Moore, M., Lam, Y., Michael, P., Chan, A., Santos, M., Rnjak-Kovacina, J., Tan, R., Wise, S. (2023). Selective NLRP3 Inflammasome Inhibitor MCC950 Suppresses Inflammation and Facilitates Healing in Vascular Materials. Advanced Science, 10(20). [More Information]

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2022

Chapman, N., Thomas, E., Tan, J., Inglis, S., Wu, J., Climie, R., Picone, D., Blekkenhorst, L., Wise, S., Mirabito Colafella, K., et al (2022). A roadmap of strategies to support cardiovascular researchers: from policy to practice. Nature Reviews Cardiology, 19(11), 765-777. [More Information]
Moore, M., Tan, R., Yang, N., Rnjak-Kovacina, J., Wise, S. (2022). Bioengineering artificial blood vessels from natural materials. Trends in Biotechnology, 40(6), 693-707. [More Information]
Liu, Q., Zhang, J., Xia, L., Wise, S., Hambly, B., Tao, K., Bao, S. (2022). Clinical implications of interleukins-31, 32, and 33 in gastric cancer. World Journal of Gastrointestinal Oncology, 14(9), 1808-1822. [More Information]
Lau, K., Heu, C., Moore, M., Zhang, A., Akhavan, B., Wise, S., Bilek, M., Lord, M., Rnjak-Kovacina, J. (2022). Effect of plasma ion immersion implantation on physiochemical and biological properties of silk towards creating a versatile biomaterial platform. Materials Today Advances, 13, 100212. [More Information]
Lam, Y., Tan, R., Michael, P., Yang, N., Dunn, L., Cooke, J., Celermajer, D., Wise, S., Ng, M. (2022). Endothelial thioredoxin interacting protein (TXNIP) modulates endothelium-dependent vasorelaxation in hyperglycemia. Microvascular research, 143. [More Information]
Wei, F., Mu, Y., Tan, R., Wise, S., Bilek, M., Zhou, Y., Xiao, Y. (2022). Osteo-Immunomodulatory Role of Interleukin-4-Immobilized Plasma Immersion Ion Implantation Membranes for Bone Regeneration. ACS Applied Materials and Interfaces. [More Information]
Michael, P., Yang, N., Moore, M., Santos, M., Lam, Y., Ward, A., Hung, J., Tan, R., Wise, S. (2022). Synthetic Vascular Graft with Spatially Distinct Architecture for Rapid Biomimetic Cell Organisation in a Perfusion Bioreactor. Biomedical Materials, 17(4), 45001. [More Information]
Lee, B., Yang, N., Santos, M., Moore, M., Grant, A., Jang, J., Akhavan, B., Bilek, M., Tan, R., Wise, S. (2022). Truncated vascular endothelial cadherin enhances rapid endothelialization of small diameter synthetic vascular grafts. Materials Today Advances, 14, 100222. [More Information]

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2021

Lam, Y., Tan, R., Michael, P., Lau, K., Yang, N., Rnjak-Kovacina, J., Wise, S. (2021). Bioengineering silk into blood vessels. Biochemical Society Transactions, 49(5), 2271-2286. [More Information]
Michael, P., Lam, Y., Hung, J., Tan, R., Santos, M., Wise, S. (2021). Comprehensive evaluation of the toxicity and biosafety of plasma polymerized nanoparticles. Nanomaterials, 11(5). [More Information]
Tan, R., Ryder, I., Yang, N., Lam, Y., Santos, M., Michael, P., Robinson, D., Ng, M., Wise, S. (2021). Macrophage Polarization as a Novel Therapeutic Target for Endovascular Intervention in Peripheral Artery Disease. JACC: Basic to Translational Science, 6(8), 693-704. [More Information]
Sharifahmadian, O., Zhai, C., Hung, J., Shineh, G., Stewart, C., Ionescu, M., Fadzil, A., Gan, Y., Wise, S., Akhavan, B. (2021). Mechanically robust nitrogen-rich plasma polymers: Biofunctional interfaces for surface engineering of biomedical implants. Materials Today Advances, 12, 100188. [More Information]
Besnier, M., Finemore, M., Yu, C., Kott, K., Vernon, S., Seebacher, N., Genetzakis, E., Furman, A., Tang, O., Davis, R., Hansen, T., Bubb, K., Wise, S., Grieve, S., Di Bartolo, B., Figtree, G., et al (2021). Patient endothelial colony-forming cells to model coronary artery disease susceptibility and unravel the role of dysregulated mitochondrial redox signalling. Antioxidants, 10(10), 1547. [More Information]
Jaure, A., Sorrell, T., Black, A., Caillaud, C., Chrzanowski, W., Li, E., Martinez-Martin, D., McEwan, A., Wang, R., Motion, A., Casas Bedoya, A., Huang, J., Azizi, L., Eggleton, B., Andersen, T., Baillie, A., Barratt, A., Boehm, C., Britton, P., Chadban, S., Chow, C., Fleming, S., Fox, G., Gordon, L., Baillie, A., Howell, M., Hickie, I., Hunt, N., Iredell, J., Jin, C., Kairaitis, K., Kavehei, O., Kritharides, L., Leon-Saval, S., Lindley, R., Maguire, S., McCluskey, M., McKay, N., Mifsud, G., Palomba, S., Pettigrew, A., Postnova, S., Prinable, J., Rabeau, J., Rees, M., Richmond, K., Scholes-Robertson, N., Seppelt, I., Shaw, T., Sintchenko, V., Snelling, T., Teixeira-Pinto, A., Tovey, E., Tuniz, A., Varamini, P., Wang, A., Wang, K., Wise, S., Zoellner, H., et al (2021). Research priorities for COVID-19 sensor technology. Nature Biotechnology, 39(2), 144-153. [More Information]
Yang, N., Moore, M., Michael, P., Santos, M., Lam, Y., Bao, S., Ng, M., Rnjak-Kovacina, J., Tan, R., Wise, S. (2021). Silk Fibroin Scaffold Architecture Regulates Inflammatory Responses and Engraftment of Bone Marrow-Mononuclear Cells. Advanced Healthcare Materials, 10(16), 2100615. [More Information]

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2020

Croes, M., Akhavan, B., Sharifahmadian, O., Fan, H., Mertens, R., Tan, R., Aliza, C., Fadzil, A., Wise, S., Kruyt, M., Bilek, M., et al (2020). A multifaceted biomimetic interface to improve the longevity of orthopedic implants. Acta Biomaterialia, 110, 266-279. [More Information]
Lam, M., Hsu, C., Simpson, P., Dunn, L., Chow, R., Chan, K., Yong, A., Yu, Y., Sieveking, D., Lecce (Venuto), L., Celermajer, D., Wise, S., Ng, M., et al (2020). Androgens Stimulate EPC-Mediated Neovascularization and Are Associated with Increased Coronary Collateralization. Endocrinology, 161(5), 1-13. [More Information]
Tan, R., Hallahan, N., Kosobrodova, E., Michael, P., Wei, F., Santos, M., Lam, Y., Chan, A., Xiao, Y., Bilek, M., Thorn, P., Wise, S. (2020). Bioactivation of Encapsulation Membranes Reduces Fibrosis and Enhances Cell Survival. ACS Applied Materials and Interfaces, 12(51), 56908-56923. [More Information]
Yang, N., Tan, R., Chan, A., Lee, B., Santos, M., Hung, J., Liao, Y., Bilek, M., Fei, J., Wise, S., Bao, B. (2020). Immobilized Macrophage Colony-Stimulating Factor (M-CSF) Regulates the Foreign Body Response to Implanted Materials. ACS Biomaterials Science and Engineering, 6(2), 995-1007. [More Information]
Climie, R., Wu, J., Calkin, A., Chapman, N., Inglis, S., Mirabito Colafella, K., Picone, D., Tan, J., Thomas, E., Viola, H., Wise, S., Figtree, G., et al (2020). Lack of Strategic Funding and Long-Term Job Security Threaten to Have Profound Effects on Cardiovascular Researcher Retention in Australia. Heart, Lung, and Circulation, 29, 1588-1595. [More Information]
Michael, P., Lam, Y., Filipe, E., Tan, R., Chan, A., Lee, B., Feng, N., Hung, J., Cox, T., Santos, M., Wise, S. (2020). Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo. Scientific Reports, 10(1), 1-14. [More Information]
Cui, X., Soliman, B., Alcala-Orozco, C., Li, J., Vis, M., Santos, M., Wise, S., Levato, R., Malda, J., Woodfield, T., et al (2020). Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape Fidelity. Advanced Healthcare Materials, 9(4), 1901667. [More Information]

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2019

Stewart, C., Akhavan, B., Wise, S., Bilek, M. (2019). A review of biomimetic surface functionalization for bone-integrating orthopedic implants: Mechanisms, current approaches, and future directions. Progress in Materials Science, 106, 1-40. [More Information]
Chan, A., Filipe, E., Tan, R., Santos, M., Yang, N., Hung, J., Feng, J., Nazir, S., Benn, A., Ng, M., Wise, S., et al (2019). Altered processing enhances the efficacy of small-diameter silk fibroin vascular grafts. Scientific Reports, 9(1), 1-14. [More Information]
Lam, M., Lecce (Venuto), L., Yuen, S., Wise, S., Handelsman, D., Karas, R., Ng, M. (2019). Androgens Ameliorate Impaired Ischemia-Induced Neovascularization due to Aging in Male Mice. Endocrinology, 160(5), 1137-1149. [More Information]
Tan, R., Chan, A., Wei, S., Santos, M., Lee, B., Filipe, E., Akhavan, B., Bilek, M., Ng, M., Xiao, Y., Wise, S. (2019). Bioactive Materials Facilitating Targeted Local Modulation of Inflammation. JACC: Basic to Translational Science, 4(1), 56-71. [More Information]
Naficy, S., Le, T., Oveissi, F., Lee, A., Hung, J., Wise, S., Winlaw, D., Dehghani, F. (2019). Highly Porous, Biocompatible Tough Hydrogels, Processable via Gel Fiber Spinning and 3D Gel Printing. Advanced Materials Interfaces, 7(3), 1-10. [More Information]
Akhavan, B., Croes, M., Wise, S., Zhai, C., Hung, J., Stewart, C., Ionescu, M., Weinans, H., Gan, Y., Yavari, S., Bilek, M. (2019). Radical-functionalized plasma polymers: Stable biomimetic interfaces for bone implant applications. Applied Materials Today, 16, 456-473. [More Information]
Biglari, S., Le, T., Tan, R., Wise, S., Zambon, A., Codolo, G., De Bernard, M., Warkiani, M., Schindeler, A., Naficy, S., Valtchev, P., Dehghani, F., et al (2019). Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model. Advanced Healthcare Materials, 8(1), 1-12. [More Information]
Santos, M., Reeves, B., Michael, P., Tan, R., Wise, S., Bilek, M. (2019). Substrate geometry modulates self-assembly and collection of plasma polymerized nanoparticles. Communications Physics, 2(1), 1-11. [More Information]

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2018

Kulkarni, K., Hung, J., Fulcher, A., Chan, A., Hong, A., Forsythe, J., Aguilar, M., Wise, S., Del Borgo, M. (2018). β3-Tripeptides Coassemble into Fluorescent Hydrogels for Serial Monitoring in Vivo. ACS Biomaterials Science and Engineering, 4(11), 3843-3847. [More Information]
Lam, M., Lecce (Venuto), L., Yuen, G., Wise, S., Handelsman, D., Ng, M. (2018). Androgen action augments ischemia-induced, bone marrow progenitor cell-mediated vasculogenesis. International Journal of Biological Sciences, 14(14), 1985-1992. [More Information]
Vanags, L., Tan, J., Galougahi, K., Schaefer, A., Wise, S., Murphy, A., Ali, Z., Bursill, C. (2018). Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype. JACC: Basic to Translational Science, 3(2), 200-209. [More Information]
Stewart, C., Akhavan, B., Santos, M., Hung, J., Hawkins, C., Bao, B., Wise, S., Bilek, M. (2018). Cellular responses to radical propagation from ion-implanted plasma polymer surfaces. Applied Surface Science, 456, 701-710. [More Information]
Degendorfer, G., Chuang, C., Mariotti, M., Hammer, A., Hoefler, G., Hagglund, P., Malle, E., Wise, S., Davies, M. (2018). Exposure of tropoelastin to peroxynitrous acid gives high yields of nitrated tyrosine residues, di-tyrosine cross-links and altered protein structure and function. Free Radical Biology and Medicine, 115, 219-231. [More Information]
Clayton, Z., Tan, R., Miravet, M., Lennartsson, K., Cooke, J., Bursill, C., Wise, S., Patel, S. (2018). Induced pluripotent stem cell-derived endothelial cells promote angiogenesis and accelerate wound closure in a murine excisional wound healing model. Bioscience Reports, 38(4), 1-11. [More Information]
Tan, R., Chan, A., Lennartsson, K., Miravet, M., Lee, B., Rnjak-Kovacina, J., Clayton, Z., Cooke, J., Ng, M., Patel, S., Wise, S. (2018). Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis. Stem Cell Research & Therapy, 9(1), 1-15. [More Information]
Stewart, C., Akhavan, B., Hung, J., Bao, B., Jang, J., Wise, S., Bilek, M. (2018). Multifunctional Protein-Immobilized Plasma Polymer Films for Orthopedic Applications. ACS Biomaterials Science and Engineering, 4(12), 4084-4094. [More Information]
Akhavan, B., Michl, T., Giles, C., Ho, K., Martin, L., Sharifahmadian, O., Wise, S., Coad, B., Kumar, N., Griesser, H., Bilek, M. (2018). Plasma activated coatings with dual action against fungi and bacteria. Applied Materials Today, 12, 72-84. [More Information]
Santos, M., Michael, P., Filipe, E., Chan, A., Hung, J., Tan, R., Lee, B., Huynh, M., Hawkins, C., Waterhouse, A., Bilek, M., Wise, S. (2018). Plasma synthesis of carbon-based nanocarriers for linker-free immobilization of bioactive cargo. ACS Applied Materials and Interfaces, 1, 580-594. [More Information]
Filipe, E., Santos, M., Hung, J., Lee, B., Yang, N., Chan, A., Ng, M., Rnjak-Kovacina, J., Wise, S. (2018). Rapid Endothelialization of Off-the-Shelf Small Diameter Silk Vascular Grafts. JACC: Basic to Translational Science, 3(1), 38-53. [More Information]
Santos, M., Waterhouse, A., Lee, B., Chan, A., Tan, R., Michael, P., Filipe, E., Hung, J., Wise, S., Bilek, M. (2018). Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings. In Gerard Wall, Halina Podbielska, Magdalena Wawrzynska (Eds.), Functionalized cardiovascular stents, (pp. 211-228). Duxford: Woodhead Publishing Limited. [More Information]

show 9 more

2017

Tan, R., Chan, A., Santos, M., Filipe, E., Akhavan, B., Lee, B., Bilek, M., Wise, S., Ng, M. (2017). A Novel Bioactive Interleukin-4 Functionalised Vascular Graft That Modulates Inflammation and Inhibits Neointimal Hyperplasia. Heart, Lung, and Circulation, 26, S279-S279. [More Information]
Wise, S., Santos, M., Michael, P., Lee, B., Hung, J., Weiss, A., Bilek, M., Ng, M. (2017). A Novel Recombinant Human Tropoelastin-Functionalised Stent Platform for Suppression of Restenosis in Peripheral Vascular Disease. Heart, Lung, and Circulation, 26, S197-S198. [More Information]
Chan, A., Tan, R., Michael, P., Lee, B., Vanags, L., Ng, M., Bursill, C., Wise, S. (2017). Evaluation of synthetic vascular grafts in a mouse carotid grafting model. PloS One, 12(3), 1-15. [More Information]
Tan, R., Lee, B., Chan, A., Yuen, S., Hung, J., Wise, S., Ng, M. (2017). Non-invasive tracking of injected bone marrow mononuclear cells to injury and implanted biomaterials. Acta Biomaterialia, 53, 378-388. [More Information]
Vanags, L., Tan, J., Santos, M., Michael, P., Ali, Z., Bilek, M., Wise, S., Bursill, C. (2017). Plasma activated coating immobilizes apolipoprotein A-I to stainless steel surfaces in its bioactive form and enhances biocompatibility. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(7), 2141-2150. [More Information]
Kondyurina, I., Wise, S., Ngo, A., Filipe, E., Kondyurin, A., Weiss, A., Bao, B., Bilek, M. (2017). Plasma mediated protein immobilisation enhances the vascular compatibility of polyurethane with tissue matched mechanical properties. Biomedical Materials, 12(4), 1-14. [More Information]
Santos, M., Bilek, M., Waterhouse, A., Lee, B., Chan, A., Tan, R., Michael, P., Filipe, E., Hung, J., Wise, S. (2017). Simple one-step covalent immobilization of bioactive agents without use of chemicals on plasma-activated low thrombogenic stent coatings. In Gerard Wall, Halina Podbielska, Magdalena Wawrzynska (Eds.), Functionalized cardiovascular stents, (pp. 211-228). Duxford: Woodhead Publishing Limited. [More Information]
Yeo, G., Baldock, C., Wise, S., Weiss, A. (2017). Targeted Modulation of Tropoelastin Structure and Assembly. ACS Biomaterials Science and Engineering, 3(11), 2832-2844. [More Information]

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2016

Wise, S., Liu, H., Yeo, G., Michael, P., Chan, A., Ngo, A., Bilek, M., Bao, B., Weiss, A. (2016). Blended Polyurethane and Tropoelastin as a Novel Class of Biologically Interactive Elastomer. Tissue Engineering - Part A, 22(5-6), 524-533. [More Information]
Santos, M., Filipe, E., Michael, P., Hung, J., Wise, S., Bilek, M. (2016). Mechanically Robust Plasma-Activated Interfaces Optimized for Vascular Stent Applications. ACS Applied Materials and Interfaces, 8(15), 9635-9650. [More Information]
Wise, S., Liu, H., Kondyurin, A., Byrom, M., Bannon, P., Edwards, G., Weiss, A., Bao, B., Bilek, M. (2016). Plasma Ion Activated Expanded Polytetrafluoroethylene Vascular Grafts with a Covalently Immobilized Recombinant Human Tropoelastin Coating Reducing Neointimal Hyperplasia. ACS Biomaterials Science and Engineering, 2(8), 1286-1297. [More Information]
Akhavan, B., Wise, S., Bilek, M. (2016). Substrate-Regulated Growth of Plasma-Polymerized Films on Carbide-Forming Metals. Langmuir, 32(42), 10835-10843. [More Information]
Yeo, G., Tarakanova, A., Baldock, C., Wise, S., Buehler, M., Weiss, A. (2016). Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly. Science Advances, 2(2), 1-14. [More Information]
Hiob, M., Trane, A., Wise, S., Bernatchez, P., Weiss, A. (2016). Tropoelastin enhances nitric oxide production by endothelial cells. Nanomedicine, 11(12), 1591-1597. [More Information]

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2015

Wakelin, E., Kondyurin, A., Wise, S., McKenzie, D., Davies, M., Bilek, M. (2015). Bio-Activation of Polyether Ether Ketone Using Plasma Immersion Ion Implantation: A Kinetic Model. Plasma Processes and Polymers, 12(2), 180-193. [More Information]
Yu, Y., Wise, S., Celermajer, D., Bilek, M., Ng, M. (2015). Bioengineering stents with proactive biocompatibility. Interventional Cardiology, 7(6), 571-584. [More Information]
Yu, Y., Wise, S., Michael, P., Bax, D., Yuen, G., Hiob, M., Yeo, G., Filipe, E., Dunn, L., Chan, K., Mollahajian, H., Celermajer, D., Weiss, A., Ng, M. (2015). Characterization of Endothelial Progenitor Cell Interactions with Human Tropoelastin. PloS One, 10(6), 1-16. [More Information]
Wise, S., Michael, P., Waterhouse, A., Santos, M., Filipe, E., Hung, J., Kondyurin, A., Bilek, M., Ng, M. (2015). Immobilization of bioactive plasmin reduces the thrombogenicity of metal surfaces. Colloids And Surfaces B: Biointerfaces, 136, 944-954. [More Information]
Wakelin, E., Fathi, A., Kracica, M., Yeo, G., Wise, S., Weiss, A., McCulloch, D., Dehghani, F., McKenzie, D., Bilek, M. (2015). Mechanical Properties of Plasma Immersion Ion Implanted PEEK for Bioactivation of Medical Devices. ACS Applied Materials and Interfaces, 7(41), 23029-23040. [More Information]

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2014

Yeo, G., Baldock, C., Wise, S., Weiss, A. (2014). A Negatively Charged Residue Stabilizes the Tropoelastin N-terminal Region for Elastic Fiber Assembly. Journal of Biological Chemistry, 289(50), 34815-34826. [More Information]
Jeewandara, T., Wise, S., Ng, M. (2014). Biocompatibility of Coronary Stents. Materials, 7(2), 769-786. [More Information]
Liu, H., Wise, S., Rnjak-Kovacina, J., Kaplan, D., Bilek, M., Weiss, A., Fei, J., Bao, B. (2014). Biocompatibility of silk-tropoelastin protein polymers. Biomaterials, 35(19), 5138-5147. [More Information]
Hajian, H., Wise, S., Bax, D., Kondyurin, A., Waterhouse, A., Dunn, L., Kielty, C., Yu, Y., Weiss, A., Bilek, M., Bannon, P., et al (2014). Immobilisation of a fibrillin-1 fragment enhances the biocompatibility of PTFE. Colloids And Surfaces B: Biointerfaces, 116, 544-552. [More Information]
Wise, S., Yeo, G., Hiob, M., Rnjak-Kovacina, J., Kaplan, D., Ng, M., Weiss, A. (2014). Tropoelastin: A versatile, bioactive assembly module. Acta Biomaterialia, 10(4), 1532-1541. [More Information]

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2013

Saitow, C., Wise, S., Weiss, A., Castellot Jr, J., Kaplan, D. (2013). Elastin biology and tissue engineering with adult cells. Biomolecular Concepts, 4(2), 173-185. [More Information]
Almine, J., Wise, S., Hiob, M., Singh, N., Tiwari, K., Vali, S., Abbasi, T., Weiss, A. (2013). Elastin sequences trigger transient proinflammatory responses by human dermal fibroblasts. The FASEB Journal, 27(9), 3455-3465. [More Information]
Hiob, M., Wise, S., Kondyurin, A., Waterhouse, A., Bilek, M., Ng, M., Weiss, A. (2013). The use of plasma-activated covalent attachment of early domains of tropoelastin to enhance vascular compatibility of surfaces. Biomaterials, 34(31), 7584-7591. [More Information]
Mithieux, S., Wise, S., Weiss, A. (2013). Tropoelastin - A multifaceted naturally smart material. Advanced Drug Delivery Reviews, 65(4), 421-428. [More Information]

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2012

Almine, J., Wise, S., Weiss, A. (2012). Elastin Signaling in Wound Repair. Birth Defects Research. Part C: Embryo Today Reviews, 96(3), 248-257. [More Information]
Rnjak-Kovacina, J., Wise, S., Li, Z., Maitz, P., Young, C., Wang, Y., Weiss, A. (2012). Electrospun synthetic human elastin: collagen composite scaffolds for dermal tissue engineering. Acta Biomaterialia, 8(10), 3714-3722. [More Information]
Wise, S., Waterhouse, A., Michael, P., Ng, M. (2012). Extracellular matrix molecules facilitating vascular biointegration. Journal of Functional Biomaterials, 3(3), 569-587. [More Information]
Waterhouse, A., Wise, S., Yin, Y., Wu, B., James, B., Zreiqat, H., McKenzie, D., Bao, B., Weiss, A., Ng, M., Bilek, M. (2012). In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomaterials, 33(32), 7984-7992. [More Information]
Wise, S., Waterhouse, A., Kondyurin, A., Bilek, M., Weiss, A. (2012). Plasma-based biofunctionalization of vascular implants. Nanomedicine, 7(12), 1907-1916. [More Information]
Ohgo, K., Niemczura, W., Seacat, B., Wise, S., Weiss, A., Kumashiro, K. (2012). Resolving Nitrogen-15 and Proton Chemical Shifts for Mobile Segments of Elastin with Two-dimensional NMR Spectroscopy. Journal of Biological Chemistry, 287(22), 18201-18209. [More Information]
Yeo, G., Baldock, C., Tuukkanen, A., Roessle, M., Dyksterhuis, L., Wise, S., Matthews, J., Mithieux, S., Weiss, A. (2012). Tropoelastin bridge region positions the cell-interactive C terminus and contributes to elastic fiber assembly. Proceedings of the National Academy of Sciences of the United States of America, 109(8), 2878-2883. [More Information]

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2011

Wise, S., Byrom, M., Waterhouse, A., Bannon, P., Ng, M., Weiss, A. (2011). A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties. Acta Biomaterialia, 7(1), 295-303. [More Information]
Waterhouse, A., Wise, S., Ng, M., Weiss, A. (2011). Elastin as a Nonthrombogenic Biomaterial. Tissue Engineering. Part B. Reviews, 17(2), 93-99. [More Information]
Rnjak-Kovacina, J., Wise, S., Mithieux, S., Weiss, A. (2011). Severe burn injuries and the role of elastin in the design of dermal substitutes. Tissue Engineering. Part B. Reviews, 17(2), 81-91. [More Information]
Waterhouse, A., Bax, D., Wise, S., Yin, Y., Dunn, L., Yeo, G., Ng, M., Bilek, M., Weiss, A. (2011). Stability of a Therapeutic Layer of Immobilized Recombinant Human Tropoelastin on a Plasma-Activated Coated Surface. Pharmaceutical Research, 28(6), 1415-1421. [More Information]
Rnjak-Kovacina, J., Wise, S., Li, Z., Maitz, P., Young, C., Wang, Y., Weiss, A. (2011). Tailoring the porosity and pore size of electrospun synthetic human elastin scaffolds for dermal tissue engineering. Biomaterials, 32(28), 6729-6736. [More Information]

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2010

Almine, J., Bax, D., Mithieux, S., Nivison-Smith, L., Rnjak-Kovacina, J., Waterhouse, A., Wise, S., Weiss, A. (2010). Elastin-based materials. Chemical Society Reviews, 39(9), 3371-3379. [More Information]
Tu, Y., Wise, S., Weiss, A. (2010). Stages in tropoelastin coalescence during synthetic elastin hydrogel formation. Micron, 41(3), 268-272. [More Information]
Waterhouse, A., Yin, Y., Wise, S., Bax, D., McKenzie, D., Bilek, M., Weiss, A., Ng, M. (2010). The immobilization of recombinant human tropoelastin on metals using a plasma-activated coating to improve the biocompatibility of coronary stents. Biomaterials, 31(32), 8332-8340. [More Information]

2009

Yin, Y., Wise, S., Nosworthy, N., Waterhouse, A., Bax, D., Youssef, H., Byrom, M., Bilek, M., McKenzie, D., Weiss, A., Ng, M. (2009). Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces. Biomaterials, 30(9), 1675-1681. [More Information]
Wise, S., Mithieux, S., Weiss, A. (2009). Engineered tropoelastin and elastin-based biomaterials. Advances in Protein Chemistry and Structural Biology.
Rnjak-Kovacina, J., Li, Z., Maitz, P., Wise, S., Weiss, A. (2009). Primary human dermal fibroblast interactions with open weave three-dimensional scaffolds prepared from synthetic human elastin. Biomaterials, 30(32), 6469-6477. [More Information]
Wise, S., Weiss, A. (2009). Tropoelastin. International Journal of Biochemistry and Cell Biology, 41(3), 494-497. [More Information]

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2008

Ng, M., Weiss, A., Wise, S. (2008). Patent No. WO2008/037028. USA, Europe, Australia.

2005

Mithieux, S., Wise, S., Raftery, M., Starcher, B., Weiss, A. (2005). A model two-component system for studying the architecture of elastin assembly in vitro. Journal of Structural Biology, 149(3), 282-289. [More Information]
Clarke, A., Wise, S., Cain, S., Kielty, C., Weiss, A. (2005). Coacervation is promoted by molecular interactions between the PF2 segment of fibrillin-1 and the domain 4 region of tropoelastin. Biochemistry. [More Information]
Wise, S., Mithieux, S., Raftery, M., Weiss, A. (2005). Specificity in the coacervation of tropoelastin: solvent exposed lysines. Journal of Structural Biology, 149(3), 273-281. [More Information]

Selected Grants

2024

Launch Fund Investment in a Project The University of Sydney & Tim C Mitchell (229430, 2021-127) Blood Vessel in a Box, Mitchell T, Wise S, DVC Research/DVCR Proof of Concept Fund

2023

Revolutionising Heart Valve Replacements with Nanotechnology, Tan R, Wise S, Ng M, National Heart Foundation of Australia/Vanguard Grant
Rewarding Research 2024, Wise S, Faculty of Medicine and Health/FMH Rewarding Research Success
3D Bioprinted Multi-Functional Wound Dressings for Diabetic Foot Ulcers, Lim K, Wise S, Ramaswamy Y, NSW Health/Elite Postdoctoral Researcher Grant

2022

Local Regulation of Inflammation for the Treatment of Peripheral Arterial Disease, Wise S, MTP Connect/Research Grant

2021

Bioengineering New Synthetic Conduits for Arterial Revascularisation, Wise S, National Heart Foundation of Australia/Future Leader Fellowship
Establishing a Centre for Pre-clinical Evaluation of Cardiovascular Devices, Wise S, NSW Health/Early Mid-Career Researcher Grant

2019

Therapeutic implication of novel carbon based nanoparticles for type 2 diabetes, Lam M, Wise S, Santos M, Tan R, Diabetes Australia/Diabetes Research Grant Program

2018

Start up funds, Wise S, Faculty of Medicine and Health/Startup funds support
Engineering a physiologically-relevant blood vessel in vitro, Wise S, Waterhouse A, Australian Research Council (ARC)/Linkage Projects (LP)
Effectively Sealing Transcatheter Heart Valves, Ng M, Wise S, National Health and Medical Research Council (NHMRC)/Development Grants
Durable Treatment of Peripheral Artery Disease, Wise S, National Foundation for Medical Research and Innovation (NFMRI)/Research Support
New Synthetic Conduits for Peripheral Revascularisation, Wise S, Ng M, Rnjak-Kovacina J, National Health and Medical Research Council (NHMRC)/Project Grants

2017

Cellular Heterogeneity in Health, Aging and Disease, Rasko J, Simpson S, Britton W, Long G, Feng C, Wise S, Oliver B, DVC Research/Sydney Research Excellence Initiative 2020 (SREI)

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Professor Steven Wise

Publications

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Selected Grants

2024

2023

2022

2021

2019

2018

2017