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Associate Professor Woojin Kim

Associate Professor

Email

woojin.kim@sydney.edu.au

Details

Member of The Centre for Drug Discovery Innovation

Member of the Brain and Mind Centre

Associate Professor Kim is a Principal Research Fellow at the University of Sydney, conducting research in dementia and motor syndromes. Previously, he has held academic and research appointments at University of New South Wales (UNSW), Neuroscience Research Australia (NeuRA) and Harvard Medical School, and I received a PhD from UNSW. The focus of his research is on understanding the pathogenesis and delivering interventions for neurodegenerative diseases. As the head of the ForeFront biomarker program, he has led pioneering research in lipidomics and neuropathology based on human blood and brain tissues. He has published 118 papers, including high-impact journals, such as Nature Comm, Brain, Neurology, Scientific Reports and Acta Neuropathologica.

Research interests

Neurodegenerative diseases

Biomarker development

Lipidomics

ATP-binding cassette subfamily A (ABCA) transporters

Frontotemporal dementia

Alzheimer’s disease

Multiple system atrophy

Motor neuron disease

Parkinson’s disease

Teaching and supervision

Neurodegenerative diseases

Molecular biology

Genetics

Neuropathology

Current projects

Developing blood biomarkers for frontotemporal dementia and motor neuron disease

Understanding the pathogenesis of synucleinopathies

Determining the function of the ABCA7 gene

Themes

Obesity, Diabetes and Cardiovascular Disease, Neurosciences and Mental Health

Keywords

Alzheimer's disease, Cell biology, Molecular biology, Movement disorders, Neurosciences

Approaches

Aetiology, Animal Models, Cellular/Molecular

Publications

By Type

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Journals

Fu, Y., Pickford, R., Galper, J., Phan, K., Wu, P., Li, H., Kim, Y., Dzamko, N., Halliday, G., Kim, W. (2024). A protective role of ABCA5 in response to elevated sphingomyelin levels in Parkinson’s disease. NPJ Parkinson's Disease, 10(1). [More Information]
da Cruz Rodrigues, K., Kim, S., Uner, A., Hou, Z., Young, J., Campolim, C., Aydogan, A., Chung, B., Choi, A., Yang, W., Kim, W., et al (2024). LRP1 in GABAergic neurons is a key link between obesity and memory function. Molecular Metabolism, 84. [More Information]
Yang, Y., Halliday, G., Naismith, S., Kim, W., Michaelian, J., Lewis, S., Phillips, C., D'Rozario, A., Chatterjee, P., Martins, R., Grunstein, R. (2024). Predicting neurodegeneration from sleep related biofluid changes. Neurobiology of Disease, 190, 106369. [More Information]
Yang, Y., Cheng, Q., Gao, J., Kim, W. (2024). Status of biomarker development for frontotemporal dementia and amyotrophic lateral sclerosis. Neural Regeneration Research, 19(10), 2117-2118. [More Information]
Zhang, S., Dauer, K., Strohäker, T., Tatenhorst, L., Caldi Gomes, L., Mayer, S., Jung, B., Kim, W., Lee, S., Becker, S., et al (2023). Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain. Brain Pathology, 33(5). [More Information]
Lok, H., Katzeff, J., Hodges, J., Piguet, O., Fu, Y., Halliday, G., Kim, W. (2023). Elevated GRO-α and IL-18 in serum and brain implicate the NLRP3 inflammasome in frontotemporal dementia. Scientific Reports, 13(1). [More Information]
Youssef, P., Hughes, L., Kim, W., Halliday, G., Lewis, S., Cooper, A., Dzamko, N. (2023). Evaluation of plasma levels of NFL, GFAP, UCHL1 and tau as Parkinson's disease biomarkers using multiplexed single molecule counting. Scientific Reports, 13(1). [More Information]
Labradorgarrido, A., Zhong, S., Hughes, L., Keshiya, S., Kim, W., Halliday, G., Dzamko, N. (2023). Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations. Frontiers in Cellular Neuroscience, 17, 1229213. [More Information]
Hsiao, T., Tanglay, O., Li, A., Strobbe, A., Kim, W., Halliday, G., Fu, Y. (2023). Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy. Cells, 12(5). [More Information]
Chedid, J., Labradorgarrido, A., Zhong, S., Gao, J., Zhao, Y., Perera, G., Kim, W., Halliday, G., Dzamko, N. (2022). A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology. Journal of Biological Chemistry, 298(8). [More Information]
Fu, Y., Zhou, L., Li, H., Hsiao, T., Li, B., Tanglay, O., Auwyang, A., Wang, E., Feng, J., Kim, W., Halliday, G., et al (2022). Adaptive structural changes in the motor cortex and white matter in Parkinson’s disease. Acta Neuropathologica, 144(5), 861-879. [More Information]
Katzeff, J., Lok, H., Bhatia, S., Fu, Y., Halliday, G., Kim, W. (2022). ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions. Frontiers in Molecular Neuroscience, 15. [More Information]
Katzeff, J., Bright, F., Phan, K., Kril, J., Ittner, L., Kassiou, M., Hodges, J., Piguet, O., Kiernan, M., Halliday, G., Kim, W. (2022). Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis. Brain, 145(5), 1598-1609. [More Information]
Fu, Y., He, Y., Phan, K., Bhatia, S., Pickford, R., Wu, P., Dzamko, N., Halliday, G., Kim, W. (2022). Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain. Acta Neuropathologica Communications, 10(1). [More Information]
Galper, J., Dean, N., Pickford, R., Lewis, S., Halliday, G., Kim, W., Dzamko, N. (2022). Lipid pathway dysfunction is prevalent in patients with Parkinson's disease. Brain, 145(10), 3472-3487. [More Information]
Galper, J., Kim, W., Dzamko, N. (2022). LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease. Biomolecules, 12(11). [More Information]
Phan, K., He, Y., Bhatia, S., Pickford, R., McDonald, G., Mazumder, S., Timmins, H., Hodges, J., Piguet, O., Dzamko, N., Halliday, G., Kiernan, M., Kim, W. (2022). Multiple pathways of lipid dysregulation in amyotrophic lateral sclerosis. Brain Communications, 5(1), 1-12. [More Information]
Frieg, B., Geraets, J., Strohäker, T., Dienemann, C., Mavroeidi, P., Jung, B., Kim, W., Lee, S., Xilouri, M., Zweckstetter, M., et al (2022). Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein. Communications Biology, 5(1). [More Information]
Fu, Y., He, Y., Phan, K., Pickford, R., Kim, Y., Dzamko, N., Halliday, G., Kim, W. (2022). Sex-specific lipid dysregulation in the Abca7 knockout mouse brain. Brain Communications, 4(3). [More Information]
Gregersen, E., Betzer, C., Kim, W., Kovacs, G., Reimer, L., Halliday, G., Thiel, S., Jensen, P. (2021). Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity. Journal of Neuroinflammation, 18(1), 177. [More Information]
Katzeff, J., Kim, W. (2021). ATP-binding cassette transporters and neurodegenerative diseases. Essays in Biochemistry, 65(7), 1013-1024. [More Information]
Youssef, P., Kim, W., Halliday, G., Lewis, S., Dzamko, N. (2021). Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson's Disease Patients. Journal of Parkinson's Disease, 11(4), 1761-1772. [More Information]
Bright, F., Katzeff, J., Hodges, J., Piguet, O., Kril, J., Halliday, G., Kim, W. (2021). Glycoprotein Pathways Altered in Frontotemporal Dementia With Autoimmune Disease. Frontiers in Immunology, 12, 736260. [More Information]
He, Y., Phan, K., Bhatia, S., Pickford, R., Fu, Y., Yang, Y., Hodges, J., Piguet, O., Halliday, G., Kim, W. (2021). Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia. Scientific Reports, 11(1), 21348. [More Information]
Phan, K., He, Y., Fu, Y., Dzamko, N., Bhatia, S., Gold, J., Rowe, D., Ke, Y., Ittner, L., Hodges, J., Piguet, O., Kiernan, M., Halliday, G., Kim, W. (2021). Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia. Communications Medicine, 1(60), 1-11. [More Information]
Newman, M., Nik, H., Sutherland, G., Hin, N., Kim, W., Halliday, G., Jayadev, S., Smith, C., Laird, A., Lucas, C., et al (2020). Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of presenilin 1. Human Molecular Genetics, 29(14), 2379-2394. [More Information]
Katzeff, J., Bright, F., Lo, K., Kril, J., Connolly, A., Crossett, B., Ittner, L., Kassiou, M., Loy, C., Hodges, J., Piguet, O., Kiernan, M., Halliday, G., Kim, W. (2020). Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation. Scientific Reports, 10(1), 13741. [More Information]
Phan, K., He, Y., Pickford, R., Bhatia, S., Katzeff, J., Hodges, J., Piguet, O., Halliday, G., Kim, W. (2020). Uncovering pathophysiological changes in frontotemporal dementia using serum lipids. Scientific Reports, 10(1), 3640. [More Information]
Bhatia, S., Kim, W., Shepherd, C., Halliday, G. (2019). Apolipoprotein D Upregulation in Alzheimer's Disease but Not Frontotemporal Dementia. Journal of Molecular Neuroscience, 67(1), 125-132. [More Information]
Lee, J., Kanai, K., Suzuki, M., Kim, W., Yoo, H., Kim, D., Fu, Y., Jung, B., Choi, M., Oh, K., Halliday, G., et al (2019). Arylsulfatase A, a genetic modifier of Parkinson's disease, is an alpha-synuclein chaperone. Brain, 142(9), 2845-2859. [More Information]
Forrest, S., Crockford, D., Sizemova, A., McCann, H., Shepherd, C., McGeachie, A., Affleck, A., Carew-Jones, F., Bartley, L., Kwok, J., Kim, W., Jary, E., Tan, R., McGinley, C., Piguet, O., Hodges, J., Kril, J., Halliday, G. (2019). Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration. Neurology, 92(21), e2472-e2482. [More Information]
Katzeff, J., Phan, K., Purushothuman, S., Halliday, G., Kim, W. (2019). Cross-examining candidate genes implicated in multiple system atrophy. Acta Neuropathologica Communications, 7(1), 1-7. [More Information]
Ahmed, R., Phan, K., Highton-Williamson, E., Strikwerda Brown, C., Caga, J., Ramsey, E., Zoing, M., Devenney, E., Kim, W., Hodges, J., Piguet, O., Halliday, G., Kiernan, M. (2019). Eating peptides: biomarkers of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia. Annals of Clinical and Translational Neurology, 6(3), 486-495. [More Information]
Hsiao, T., Purushothuman, S., Jensen, P., Halliday, G., Kim, W. (2019). Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. Frontiers in Neuroscience, 13, 1-5. [More Information]
Strohaker, T., Jung, B., Liou, S., Fernandez, C., Riedel, D., Becker, S., Halliday, G., Bennati, M., Kim, W., Lee, S., et al (2019). Structural heterogeneity of alpha-synuclein fibrils amplified from patient brain extracts. Nature Communications, 10(1), 1-12. [More Information]
Kim, W., He, Y., Phan, K., Ahmed, R., Rye, K., Piguet, O., Hodges, J., Halliday, G. (2018). Altered high density lipoprotein composition in behavioral variant frontotemporal dementia. Frontiers in Neuroscience, 12, 847. [More Information]
Kim, W., Fu, Y., Dobson-Stone, C., Hsiao, J., Shang, K., Hallupp, M., Schofield, P., Garner, B., Karl, T., Kwok, J. (2018). Effect of Fluvoxamine on Amyloid-beta Peptide Generation and Memory. Journal of Alzheimer's Disease, 62(4), 1777-1787. [More Information]
Ahmed, R., Highton-Williamson, E., Caga, J., Thornton, N., Ramsey, E., Zoing, M., Kim, W., Halliday, G., Piguet, O., Hodges, J., Kiernan, M., et al (2018). Lipid Metabolism and Survival Across the Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Spectrum: Relationships to Eating Behavior and Cognition. Journal of Alzheimer's Disease, 61(2), 773-783. [More Information]
Kim, W., Jary, E., Pickford, R., He, Y., Ahmed, R., Piguet, O., Hodges, J., Halliday, G. (2018). Lipidomics analysis of Behavioral Variant Frontotemporal Dementia: a scope for Biomarker Development. Frontiers in Neurology, 9, 1-11. [More Information]
Rusznak, Z., Sengul, G., Paxinos, G., Kim, W., Fu, Y. (2018). Odor Enrichment Increases Hippocampal Neuron Numbers in Mouse. Experimental Neurobiology, 27(2), 94-102. [More Information]
Atashrazm, F., Hammond, D., Perera, G., Dobson-Stone, C., Mueller, N., Pickford, R., Kim, W., Kwok, J., Lewis, S., Halliday, G., Dzamko, N. (2018). Reduced glucocerebrosidase activity in monocytes from patients with Parkinson's disease. Scientific Reports, 8(1), 1-12. [More Information]
Forrest, S., Kril, J., Stevens, C., Kwok, J., Hallupp, M., Kim, W., Huang, Y., McGinley, C., Werka, H., Kiernan, M., Hodges, J., Halliday, G., et al (2018). Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies. Brain, 141(2), 521-534. [More Information]
Hsiao, T., Halliday, G., Kim, W. (2017). (alpha)-Synuclein regulates neuronal cholesterol efflux. Molecules, 22(10), 1-8. [More Information]
Bhatia, S., Fu, Y., Hsiao, T., Halliday, G., Kim, W. (2017). Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels. Journal of Alzheimer's Disease Reports, 1, 237-247. [More Information]
Tan, R., Yang, Y., Kim, W., Dobson-Stone, C., Kwok, J., Kiernan, M., Halliday, G. (2017). Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 5(76), 1-7. [More Information]
Van Langenhove, T., Piquet, O., Burrell, J., Leyton, C., Foxe, D., Abela, M., Bartley, L., Kim, W., Jary, E., Huang, Y., Hodges, J., et al (2017). Predicting development of amyotrophic lateral sclerosis in frontotemporal dementia. Journal of Alzheimer's Disease, 58(1), 163-170. [More Information]
Fu, Y., Hsiao, J., Paxinos, G., Halliday, G., Kim, W. (2016). ABCA7 Mediates Phagocytic Clearance of Amyloid-(beta) in the Brain. Journal of Alzheimer's Disease, 54(2), 569-584. [More Information]
Rusznák, Z., Henskens, W., Schofield, E., Kim, W., Fu, Y. (2016). Adult neurogenesis and gliogenesis: Possible mechanisms for neurorestoration. Experimental Neurobiology, 25(3), 103-112. [More Information]
Bleasel, J., Halliday, G., Kim, W. (2016). Animal modeling an oligodendrogliopathy - multiple system atrophy. Acta Neuropathologica Communications, 4(1), 1-15. [More Information]
Coupland, K., Kim, W., Halliday, G., Hallupp, M., Dobson-Stone, C., Kwok, J. (2016). Role of the long non-coding RNA MAPT-AS1 in regulation of microtubule associated protein tau (MAPT) expression in Parkinson's disease. PloS One, 11(6), 1-14. [More Information]
Fu, Y., Hsiao, J., Paxinos, G., Halliday, G., Kim, W. (2015). ABCA5 Regulates amyloid-beta peptide production and is associated with Alzheimer's disease neuropathology. Journal of Alzheimer's Disease, 43(3), 857-869. [More Information]
Rusznak, Z., Kim, W., Hsiao, J., Halliday, G., Paxinos, G., Fu, Y. (2015). Early in vivo effects of the human mutant amyloid-? protein precursor (hA?PPSwInd) on the mouse olfactory bulb. Journal of Alzheimer's Disease, 49(2), 443-457. [More Information]
Coupland, K., Kim, W., Halliday, G., Hallupp, M., Dobson-Stone, C., Kwok, J. (2015). Effect of PSEN1 mutations on MAPT methylation in early-onset Alzheimer's disease. Current Alzheimer Research, 12(8), 745-751. [More Information]
Mills, J., Kavanagh, T., Kim, W., Chen, B., Waters, P., Halliday, G., Janitz, M. (2015). High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation. Molecular Brain, 8(1), 1-12. [More Information]
Mills, J., Chen, J., Kim, W., Waters, P., Prabowo, A., Aronica, E., Halliday, G., Janitz, M. (2015). Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter. Neurogenetics, 16(3), 201-213. [More Information]
Mills, J., Kim, W., Halliday, G., Janitz, M. (2015). Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy. Neurogenetics, 16(2), 107-122. [More Information]
Fu, Y., Rusznak, Z., Kwok, J., Kim, W., Paxinos, G. (2014). Age-Dependent Alterations of the Hippocampal Cell Composition and Proliferative Potential in the hA-Beta-PPSwInd-J20 Mouse. Journal of Alzheimer's Disease, 41(4), 1177-1192. [More Information]
Kim, W., Kagedal, K., Halliday, G. (2014). Alpha-synuclein biology in Lewy body diseases. Alzheimer's Research and Therapy, 6(1), 1-9. [More Information]
Don, A., Hsiao, J., Bleasel, J., Couttas, T., Halliday, G., Kim, W. (2014). Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathologica Communications, 2(1), 1-14. [More Information]
Coupland, K., Mellick, G., Silburn, P., Mather, K., Armstrong, N., Sachdev, P., Brodaty, H., Huang, Y., Halliday, G., Hallupp, M., et al (2014). DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E in vitro. Movement Disorders, 29(13), 1606-1614. [More Information]
Wong, J., Halliday, G., Kim, W. (2014). Exploring myelin dysfunction in multiple system atrophy. Experimental Neurobiology, 23(4), 337-344. [More Information]
Bleasel, J., Wong, J., Halliday, G., Kim, W. (2014). Lipid dysfunction and pathogenesis of multiple system atrophy. Acta Neuropathologica Communications, 2(1), 1-11. [More Information]
Murphy, K., Gysbers, A., Abbott, S., Tayebi, N., Kim, W., Sidransky, E., Cooper, A., Garner, B., Halliday, G. (2014). Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease. Brain, 137(3), 834-848. [More Information]
Kim, W., Hsiao, J., Bhatia, S., Glaros, E., Don, A., Tsuruoka, S., Weickert, C., Halliday, G. (2013). ABCA8 stimulates sphingomyelin production in oligodendrocytes. Biochemical Journal, 452(3), 401-410. [More Information]
Kim, W., Li, H., Ruberu, K., Chan, S., Elliott, D., Low, J., Cheng, D., Karl, T., Garner, B. (2013). Deletion of Abca7 Increases Cerebral Amyloid-Beta Accumulation in the J20 Mouse Model of Alzheimer's Disease. Journal of Neuroscience, 33(10), 4387-4394. [More Information]
Hsiao, J., Fu, Y., Hill, A., Halliday, G., Kim, W. (2013). Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation. PloS One, 8(8), 1-10. [More Information]
Dang, T., Dobson-Stone, C., Glaros, E., Kim, W., Hallupp, M., Bartley, L., Piguet, O., Hodges, J., Halliday, G., Double, K., et al (2013). Endogenous progesterone levels and frontotemporal dementia: Modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model. Disease Models and Mechanisms, 6(5), 1198-1204. [More Information]
Bleasel, J., Hsiao, J., Halliday, G., Kim, W. (2013). Increased expression of ABCA8 in multiple system atrophy brain is associated with changes in pathogenic proteins. Journal of Parkinson's Disease, 3(3), 331-339. [More Information]
Kavanagh, T., Mills, J., Kim, W., Halliday, G., Janitz, M. (2013). Pathway analysis of the human brain transcriptome in disease. Journal of Molecular Neuroscience, 51(1), 28-36. [More Information]
Mills, J., Kavanagh, T., Kim, W., Chen, B., Kawahara, Y., Halliday, G., Janitz, M. (2013). Unique Transcriptome Patterns of the White and Grey Matter Corroborate Structural and Functional Heterogeneity in the Human Frontal Lobe. PloS One, 8(10), 1-18. [More Information]
Kim, W., Halliday, G. (2012). Changes in sphingomyelin level affect alpha-synuclein and ABCA5 expression. Journal of Parkinson's Disease, 2(1), 41-46. [More Information]
Karl, T., Bhatia, S., Cheng, D., Kim, W., Garner, B. (2012). Cognitive phenotyping of amyloid precursor protein transgenic J20 mice. Behavioural Brain Research, 228(2), 392-397. [More Information]
Elliott, D., Kim, W., Gorrisen, S., Halliday, G., Kwok, J. (2012). Leucine-Rich Repeat Kinase 2 and Alternative Splicing in Parkinson's Disease. Movement Disorders, 27(8), 1004-1011. [More Information]
Logge, W., Cheng, D., Chesworth, R., Bhatia, S., Garner, B., Kim, W., Karl, T. (2012). Role of Abca7 in Mouse Behaviours Relevant to Neurodegenerative Diseases. PloS One, 7(9), 1-9. [More Information]
Bhatia, S., Knoch, B., Wong, J., Kim, W., Else, P., Oakley, A., Garner, B. (2012). Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: Implications for lipid antioxidant activity and Alzheimer's disease. Biochemical Journal, 442(3), 713-721. [More Information]
Elliott, D., Tsoi, K., Holinkova, S., Chan, S., Kim, W., Halliday, G., Rye, K., Garner, B. (2011). Isoform-specific proteolysis of apolipoprotein-E in the brain. Neurobiology of Aging, 32(2), 257-271. [More Information]
Cheng, D., Jenner, A., Shui, G., Cheong, W., Mitchell, T., Nealon, J., Kim, W., McCann, H., Wenk, M., Halliday, G., et al (2011). Lipid pathway alterations in parkinson's disease primary visual cortex. PloS One, 6(2), 1-17. [More Information]
Kim, W., Hill, A., Fitzgerald, M., Freeman, M., Evin, G., Garner, B. (2011). Wild Type and Tangier Disease ABCA1 Mutants Modulate Cellular Amyloid-Beta Production Independent of Cholesterol Efflux Activity. Journal of Alzheimer's Disease, 27(2), 441-452. [More Information]
Li, H., Kim, W., Guillemin, G., Hill, A., Evin, G., Garner, B. (2010). Modulation of amyloid precursor protein processing by synthetic ceramide analogues. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1801 (8), 887-895. [More Information]
Kim, W., Chan, S., Hill, A., Guillemin, G., Garner, B. (2009). Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons. Journal of Alzheimer's Disease, 16(1), 121-131. [More Information]
Kim, W., Elliott, D., Kockx, M., Kritharides, L., Rye, K., Jans, D., Garner, B. (2008). Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches. Biochemical Journal, 409(3), 701-709. [More Information]
Chan, S., Kim, W., Kwok, J., Hill, A., Cappai, R., Rye, K., Garner, B. (2008). ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro. Journal of Neurochemistry, 106(2), 793-804. [More Information]
Glaros, E., Kim, W., Quinn, C., Jessup, W., Rye, K., Garner, B. (2008). Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice. Journal of Lipid Research, 49(2), 324-331. [More Information]
Glaros, E., Kim, W., Rye, K., Shayman, J., Garner, B. (2008). Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice. Journal of Lipid Research, 49(8), 1677-1681. [More Information]
Glaros, E., Kim, W., Wu, B., Suarna, C., Quinn, C., Rye, K., Stocker, R., Jessup, W., Garner, B. (2007). Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration. Biochemical Pharmacology, 73(9), 1340-1346. [More Information]
Kim, W., Rahmanto, A., Kamili, A., Rye, K., Guillemin, G., Gelissen, I., Jessup, W., Hill, A., Garner, B. (2007). Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid- Peptide Generation. Journal of Biological Chemistry, 282, 2851-2861.
Kim, W., Guillemin, G., Glaros, E., Lim, C., Garner, B. (2006). Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. NeuroReport, 17(9), 891-896. [More Information]
Kim, W., Rahmanto, A., Kamili, A., Rye, K., Guillemin, G., Gelissen, I., Jessup, W., Hill, A., Garner, B. (2006). Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein-E discs and suppression of amyloid-beta peptide generation. Journal of Biological Chemistry, 282(5), 2851-2861. [More Information]
Glaros, E., Kim, W., Quinn, C., Wong, J., Gelissen, I., Jessup, W., Garner, B. (2005). Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. Journal of Biological Chemistry, 280, 24515-24523.

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2024

Fu, Y., Pickford, R., Galper, J., Phan, K., Wu, P., Li, H., Kim, Y., Dzamko, N., Halliday, G., Kim, W. (2024). A protective role of ABCA5 in response to elevated sphingomyelin levels in Parkinson’s disease. NPJ Parkinson's Disease, 10(1). [More Information]
da Cruz Rodrigues, K., Kim, S., Uner, A., Hou, Z., Young, J., Campolim, C., Aydogan, A., Chung, B., Choi, A., Yang, W., Kim, W., et al (2024). LRP1 in GABAergic neurons is a key link between obesity and memory function. Molecular Metabolism, 84. [More Information]
Yang, Y., Halliday, G., Naismith, S., Kim, W., Michaelian, J., Lewis, S., Phillips, C., D'Rozario, A., Chatterjee, P., Martins, R., Grunstein, R. (2024). Predicting neurodegeneration from sleep related biofluid changes. Neurobiology of Disease, 190, 106369. [More Information]
Yang, Y., Cheng, Q., Gao, J., Kim, W. (2024). Status of biomarker development for frontotemporal dementia and amyotrophic lateral sclerosis. Neural Regeneration Research, 19(10), 2117-2118. [More Information]

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2023

Zhang, S., Dauer, K., Strohäker, T., Tatenhorst, L., Caldi Gomes, L., Mayer, S., Jung, B., Kim, W., Lee, S., Becker, S., et al (2023). Alpha-synuclein fibrils amplified from multiple system atrophy and Parkinson's disease patient brain spread after intracerebral injection into mouse brain. Brain Pathology, 33(5). [More Information]
Lok, H., Katzeff, J., Hodges, J., Piguet, O., Fu, Y., Halliday, G., Kim, W. (2023). Elevated GRO-α and IL-18 in serum and brain implicate the NLRP3 inflammasome in frontotemporal dementia. Scientific Reports, 13(1). [More Information]
Youssef, P., Hughes, L., Kim, W., Halliday, G., Lewis, S., Cooper, A., Dzamko, N. (2023). Evaluation of plasma levels of NFL, GFAP, UCHL1 and tau as Parkinson's disease biomarkers using multiplexed single molecule counting. Scientific Reports, 13(1). [More Information]
Labradorgarrido, A., Zhong, S., Hughes, L., Keshiya, S., Kim, W., Halliday, G., Dzamko, N. (2023). Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations. Frontiers in Cellular Neuroscience, 17, 1229213. [More Information]
Hsiao, T., Tanglay, O., Li, A., Strobbe, A., Kim, W., Halliday, G., Fu, Y. (2023). Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy. Cells, 12(5). [More Information]

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2022

Chedid, J., Labradorgarrido, A., Zhong, S., Gao, J., Zhao, Y., Perera, G., Kim, W., Halliday, G., Dzamko, N. (2022). A small molecule toll-like receptor antagonist rescues α-synuclein fibril pathology. Journal of Biological Chemistry, 298(8). [More Information]
Fu, Y., Zhou, L., Li, H., Hsiao, T., Li, B., Tanglay, O., Auwyang, A., Wang, E., Feng, J., Kim, W., Halliday, G., et al (2022). Adaptive structural changes in the motor cortex and white matter in Parkinson’s disease. Acta Neuropathologica, 144(5), 861-879. [More Information]
Katzeff, J., Lok, H., Bhatia, S., Fu, Y., Halliday, G., Kim, W. (2022). ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions. Frontiers in Molecular Neuroscience, 15. [More Information]
Katzeff, J., Bright, F., Phan, K., Kril, J., Ittner, L., Kassiou, M., Hodges, J., Piguet, O., Kiernan, M., Halliday, G., Kim, W. (2022). Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis. Brain, 145(5), 1598-1609. [More Information]
Fu, Y., He, Y., Phan, K., Bhatia, S., Pickford, R., Wu, P., Dzamko, N., Halliday, G., Kim, W. (2022). Increased unsaturated lipids underlie lipid peroxidation in synucleinopathy brain. Acta Neuropathologica Communications, 10(1). [More Information]
Galper, J., Dean, N., Pickford, R., Lewis, S., Halliday, G., Kim, W., Dzamko, N. (2022). Lipid pathway dysfunction is prevalent in patients with Parkinson's disease. Brain, 145(10), 3472-3487. [More Information]
Galper, J., Kim, W., Dzamko, N. (2022). LRRK2 and Lipid Pathways: Implications for Parkinson’s Disease. Biomolecules, 12(11). [More Information]
Phan, K., He, Y., Bhatia, S., Pickford, R., McDonald, G., Mazumder, S., Timmins, H., Hodges, J., Piguet, O., Dzamko, N., Halliday, G., Kiernan, M., Kim, W. (2022). Multiple pathways of lipid dysregulation in amyotrophic lateral sclerosis. Brain Communications, 5(1), 1-12. [More Information]
Frieg, B., Geraets, J., Strohäker, T., Dienemann, C., Mavroeidi, P., Jung, B., Kim, W., Lee, S., Xilouri, M., Zweckstetter, M., et al (2022). Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein. Communications Biology, 5(1). [More Information]
Fu, Y., He, Y., Phan, K., Pickford, R., Kim, Y., Dzamko, N., Halliday, G., Kim, W. (2022). Sex-specific lipid dysregulation in the Abca7 knockout mouse brain. Brain Communications, 4(3). [More Information]

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2021

Gregersen, E., Betzer, C., Kim, W., Kovacs, G., Reimer, L., Halliday, G., Thiel, S., Jensen, P. (2021). Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity. Journal of Neuroinflammation, 18(1), 177. [More Information]
Katzeff, J., Kim, W. (2021). ATP-binding cassette transporters and neurodegenerative diseases. Essays in Biochemistry, 65(7), 1013-1024. [More Information]
Youssef, P., Kim, W., Halliday, G., Lewis, S., Dzamko, N. (2021). Comparison of Different Platform Immunoassays for the Measurement of Plasma Alpha-Synuclein in Parkinson's Disease Patients. Journal of Parkinson's Disease, 11(4), 1761-1772. [More Information]
Bright, F., Katzeff, J., Hodges, J., Piguet, O., Kril, J., Halliday, G., Kim, W. (2021). Glycoprotein Pathways Altered in Frontotemporal Dementia With Autoimmune Disease. Frontiers in Immunology, 12, 736260. [More Information]
He, Y., Phan, K., Bhatia, S., Pickford, R., Fu, Y., Yang, Y., Hodges, J., Piguet, O., Halliday, G., Kim, W. (2021). Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia. Scientific Reports, 11(1), 21348. [More Information]
Phan, K., He, Y., Fu, Y., Dzamko, N., Bhatia, S., Gold, J., Rowe, D., Ke, Y., Ittner, L., Hodges, J., Piguet, O., Kiernan, M., Halliday, G., Kim, W. (2021). Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia. Communications Medicine, 1(60), 1-11. [More Information]

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2020

Newman, M., Nik, H., Sutherland, G., Hin, N., Kim, W., Halliday, G., Jayadev, S., Smith, C., Laird, A., Lucas, C., et al (2020). Accelerated loss of hypoxia response in zebrafish with familial Alzheimer's disease-like mutation of presenilin 1. Human Molecular Genetics, 29(14), 2379-2394. [More Information]
Katzeff, J., Bright, F., Lo, K., Kril, J., Connolly, A., Crossett, B., Ittner, L., Kassiou, M., Loy, C., Hodges, J., Piguet, O., Kiernan, M., Halliday, G., Kim, W. (2020). Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation. Scientific Reports, 10(1), 13741. [More Information]
Phan, K., He, Y., Pickford, R., Bhatia, S., Katzeff, J., Hodges, J., Piguet, O., Halliday, G., Kim, W. (2020). Uncovering pathophysiological changes in frontotemporal dementia using serum lipids. Scientific Reports, 10(1), 3640. [More Information]

2019

Bhatia, S., Kim, W., Shepherd, C., Halliday, G. (2019). Apolipoprotein D Upregulation in Alzheimer's Disease but Not Frontotemporal Dementia. Journal of Molecular Neuroscience, 67(1), 125-132. [More Information]
Lee, J., Kanai, K., Suzuki, M., Kim, W., Yoo, H., Kim, D., Fu, Y., Jung, B., Choi, M., Oh, K., Halliday, G., et al (2019). Arylsulfatase A, a genetic modifier of Parkinson's disease, is an alpha-synuclein chaperone. Brain, 142(9), 2845-2859. [More Information]
Forrest, S., Crockford, D., Sizemova, A., McCann, H., Shepherd, C., McGeachie, A., Affleck, A., Carew-Jones, F., Bartley, L., Kwok, J., Kim, W., Jary, E., Tan, R., McGinley, C., Piguet, O., Hodges, J., Kril, J., Halliday, G. (2019). Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration. Neurology, 92(21), e2472-e2482. [More Information]
Katzeff, J., Phan, K., Purushothuman, S., Halliday, G., Kim, W. (2019). Cross-examining candidate genes implicated in multiple system atrophy. Acta Neuropathologica Communications, 7(1), 1-7. [More Information]
Ahmed, R., Phan, K., Highton-Williamson, E., Strikwerda Brown, C., Caga, J., Ramsey, E., Zoing, M., Devenney, E., Kim, W., Hodges, J., Piguet, O., Halliday, G., Kiernan, M. (2019). Eating peptides: biomarkers of neurodegeneration in amyotrophic lateral sclerosis and frontotemporal dementia. Annals of Clinical and Translational Neurology, 6(3), 486-495. [More Information]
Hsiao, T., Purushothuman, S., Jensen, P., Halliday, G., Kim, W. (2019). Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain. Frontiers in Neuroscience, 13, 1-5. [More Information]
Strohaker, T., Jung, B., Liou, S., Fernandez, C., Riedel, D., Becker, S., Halliday, G., Bennati, M., Kim, W., Lee, S., et al (2019). Structural heterogeneity of alpha-synuclein fibrils amplified from patient brain extracts. Nature Communications, 10(1), 1-12. [More Information]

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2018

Kim, W., He, Y., Phan, K., Ahmed, R., Rye, K., Piguet, O., Hodges, J., Halliday, G. (2018). Altered high density lipoprotein composition in behavioral variant frontotemporal dementia. Frontiers in Neuroscience, 12, 847. [More Information]
Kim, W., Fu, Y., Dobson-Stone, C., Hsiao, J., Shang, K., Hallupp, M., Schofield, P., Garner, B., Karl, T., Kwok, J. (2018). Effect of Fluvoxamine on Amyloid-beta Peptide Generation and Memory. Journal of Alzheimer's Disease, 62(4), 1777-1787. [More Information]
Ahmed, R., Highton-Williamson, E., Caga, J., Thornton, N., Ramsey, E., Zoing, M., Kim, W., Halliday, G., Piguet, O., Hodges, J., Kiernan, M., et al (2018). Lipid Metabolism and Survival Across the Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Spectrum: Relationships to Eating Behavior and Cognition. Journal of Alzheimer's Disease, 61(2), 773-783. [More Information]
Kim, W., Jary, E., Pickford, R., He, Y., Ahmed, R., Piguet, O., Hodges, J., Halliday, G. (2018). Lipidomics analysis of Behavioral Variant Frontotemporal Dementia: a scope for Biomarker Development. Frontiers in Neurology, 9, 1-11. [More Information]
Rusznak, Z., Sengul, G., Paxinos, G., Kim, W., Fu, Y. (2018). Odor Enrichment Increases Hippocampal Neuron Numbers in Mouse. Experimental Neurobiology, 27(2), 94-102. [More Information]
Atashrazm, F., Hammond, D., Perera, G., Dobson-Stone, C., Mueller, N., Pickford, R., Kim, W., Kwok, J., Lewis, S., Halliday, G., Dzamko, N. (2018). Reduced glucocerebrosidase activity in monocytes from patients with Parkinson's disease. Scientific Reports, 8(1), 1-12. [More Information]
Forrest, S., Kril, J., Stevens, C., Kwok, J., Hallupp, M., Kim, W., Huang, Y., McGinley, C., Werka, H., Kiernan, M., Hodges, J., Halliday, G., et al (2018). Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies. Brain, 141(2), 521-534. [More Information]

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2017

Hsiao, T., Halliday, G., Kim, W. (2017). (alpha)-Synuclein regulates neuronal cholesterol efflux. Molecules, 22(10), 1-8. [More Information]
Bhatia, S., Fu, Y., Hsiao, T., Halliday, G., Kim, W. (2017). Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels. Journal of Alzheimer's Disease Reports, 1, 237-247. [More Information]
Tan, R., Yang, Y., Kim, W., Dobson-Stone, C., Kwok, J., Kiernan, M., Halliday, G. (2017). Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 5(76), 1-7. [More Information]
Van Langenhove, T., Piquet, O., Burrell, J., Leyton, C., Foxe, D., Abela, M., Bartley, L., Kim, W., Jary, E., Huang, Y., Hodges, J., et al (2017). Predicting development of amyotrophic lateral sclerosis in frontotemporal dementia. Journal of Alzheimer's Disease, 58(1), 163-170. [More Information]

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2016

Fu, Y., Hsiao, J., Paxinos, G., Halliday, G., Kim, W. (2016). ABCA7 Mediates Phagocytic Clearance of Amyloid-(beta) in the Brain. Journal of Alzheimer's Disease, 54(2), 569-584. [More Information]
Rusznák, Z., Henskens, W., Schofield, E., Kim, W., Fu, Y. (2016). Adult neurogenesis and gliogenesis: Possible mechanisms for neurorestoration. Experimental Neurobiology, 25(3), 103-112. [More Information]
Bleasel, J., Halliday, G., Kim, W. (2016). Animal modeling an oligodendrogliopathy - multiple system atrophy. Acta Neuropathologica Communications, 4(1), 1-15. [More Information]
Coupland, K., Kim, W., Halliday, G., Hallupp, M., Dobson-Stone, C., Kwok, J. (2016). Role of the long non-coding RNA MAPT-AS1 in regulation of microtubule associated protein tau (MAPT) expression in Parkinson's disease. PloS One, 11(6), 1-14. [More Information]

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2015

Fu, Y., Hsiao, J., Paxinos, G., Halliday, G., Kim, W. (2015). ABCA5 Regulates amyloid-beta peptide production and is associated with Alzheimer's disease neuropathology. Journal of Alzheimer's Disease, 43(3), 857-869. [More Information]
Rusznak, Z., Kim, W., Hsiao, J., Halliday, G., Paxinos, G., Fu, Y. (2015). Early in vivo effects of the human mutant amyloid-? protein precursor (hA?PPSwInd) on the mouse olfactory bulb. Journal of Alzheimer's Disease, 49(2), 443-457. [More Information]
Coupland, K., Kim, W., Halliday, G., Hallupp, M., Dobson-Stone, C., Kwok, J. (2015). Effect of PSEN1 mutations on MAPT methylation in early-onset Alzheimer's disease. Current Alzheimer Research, 12(8), 745-751. [More Information]
Mills, J., Kavanagh, T., Kim, W., Chen, B., Waters, P., Halliday, G., Janitz, M. (2015). High expression of long intervening non-coding RNA OLMALINC in the human cortical white matter is associated with regulation of oligodendrocyte maturation. Molecular Brain, 8(1), 1-12. [More Information]
Mills, J., Chen, J., Kim, W., Waters, P., Prabowo, A., Aronica, E., Halliday, G., Janitz, M. (2015). Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter. Neurogenetics, 16(3), 201-213. [More Information]
Mills, J., Kim, W., Halliday, G., Janitz, M. (2015). Transcriptome analysis of grey and white matter cortical tissue in multiple system atrophy. Neurogenetics, 16(2), 107-122. [More Information]

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2014

Fu, Y., Rusznak, Z., Kwok, J., Kim, W., Paxinos, G. (2014). Age-Dependent Alterations of the Hippocampal Cell Composition and Proliferative Potential in the hA-Beta-PPSwInd-J20 Mouse. Journal of Alzheimer's Disease, 41(4), 1177-1192. [More Information]
Kim, W., Kagedal, K., Halliday, G. (2014). Alpha-synuclein biology in Lewy body diseases. Alzheimer's Research and Therapy, 6(1), 1-9. [More Information]
Don, A., Hsiao, J., Bleasel, J., Couttas, T., Halliday, G., Kim, W. (2014). Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy. Acta Neuropathologica Communications, 2(1), 1-14. [More Information]
Coupland, K., Mellick, G., Silburn, P., Mather, K., Armstrong, N., Sachdev, P., Brodaty, H., Huang, Y., Halliday, G., Hallupp, M., et al (2014). DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E in vitro. Movement Disorders, 29(13), 1606-1614. [More Information]
Wong, J., Halliday, G., Kim, W. (2014). Exploring myelin dysfunction in multiple system atrophy. Experimental Neurobiology, 23(4), 337-344. [More Information]
Bleasel, J., Wong, J., Halliday, G., Kim, W. (2014). Lipid dysfunction and pathogenesis of multiple system atrophy. Acta Neuropathologica Communications, 2(1), 1-11. [More Information]
Murphy, K., Gysbers, A., Abbott, S., Tayebi, N., Kim, W., Sidransky, E., Cooper, A., Garner, B., Halliday, G. (2014). Reduced glucocerebrosidase is associated with increased alpha-synuclein in sporadic Parkinson's disease. Brain, 137(3), 834-848. [More Information]

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2013

Kim, W., Hsiao, J., Bhatia, S., Glaros, E., Don, A., Tsuruoka, S., Weickert, C., Halliday, G. (2013). ABCA8 stimulates sphingomyelin production in oligodendrocytes. Biochemical Journal, 452(3), 401-410. [More Information]
Kim, W., Li, H., Ruberu, K., Chan, S., Elliott, D., Low, J., Cheng, D., Karl, T., Garner, B. (2013). Deletion of Abca7 Increases Cerebral Amyloid-Beta Accumulation in the J20 Mouse Model of Alzheimer's Disease. Journal of Neuroscience, 33(10), 4387-4394. [More Information]
Hsiao, J., Fu, Y., Hill, A., Halliday, G., Kim, W. (2013). Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation. PloS One, 8(8), 1-10. [More Information]
Dang, T., Dobson-Stone, C., Glaros, E., Kim, W., Hallupp, M., Bartley, L., Piguet, O., Hodges, J., Halliday, G., Double, K., et al (2013). Endogenous progesterone levels and frontotemporal dementia: Modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model. Disease Models and Mechanisms, 6(5), 1198-1204. [More Information]
Bleasel, J., Hsiao, J., Halliday, G., Kim, W. (2013). Increased expression of ABCA8 in multiple system atrophy brain is associated with changes in pathogenic proteins. Journal of Parkinson's Disease, 3(3), 331-339. [More Information]
Kavanagh, T., Mills, J., Kim, W., Halliday, G., Janitz, M. (2013). Pathway analysis of the human brain transcriptome in disease. Journal of Molecular Neuroscience, 51(1), 28-36. [More Information]
Mills, J., Kavanagh, T., Kim, W., Chen, B., Kawahara, Y., Halliday, G., Janitz, M. (2013). Unique Transcriptome Patterns of the White and Grey Matter Corroborate Structural and Functional Heterogeneity in the Human Frontal Lobe. PloS One, 8(10), 1-18. [More Information]

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2012

Kim, W., Halliday, G. (2012). Changes in sphingomyelin level affect alpha-synuclein and ABCA5 expression. Journal of Parkinson's Disease, 2(1), 41-46. [More Information]
Karl, T., Bhatia, S., Cheng, D., Kim, W., Garner, B. (2012). Cognitive phenotyping of amyloid precursor protein transgenic J20 mice. Behavioural Brain Research, 228(2), 392-397. [More Information]
Elliott, D., Kim, W., Gorrisen, S., Halliday, G., Kwok, J. (2012). Leucine-Rich Repeat Kinase 2 and Alternative Splicing in Parkinson's Disease. Movement Disorders, 27(8), 1004-1011. [More Information]
Logge, W., Cheng, D., Chesworth, R., Bhatia, S., Garner, B., Kim, W., Karl, T. (2012). Role of Abca7 in Mouse Behaviours Relevant to Neurodegenerative Diseases. PloS One, 7(9), 1-9. [More Information]
Bhatia, S., Knoch, B., Wong, J., Kim, W., Else, P., Oakley, A., Garner, B. (2012). Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: Implications for lipid antioxidant activity and Alzheimer's disease. Biochemical Journal, 442(3), 713-721. [More Information]

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2011

Elliott, D., Tsoi, K., Holinkova, S., Chan, S., Kim, W., Halliday, G., Rye, K., Garner, B. (2011). Isoform-specific proteolysis of apolipoprotein-E in the brain. Neurobiology of Aging, 32(2), 257-271. [More Information]
Cheng, D., Jenner, A., Shui, G., Cheong, W., Mitchell, T., Nealon, J., Kim, W., McCann, H., Wenk, M., Halliday, G., et al (2011). Lipid pathway alterations in parkinson's disease primary visual cortex. PloS One, 6(2), 1-17. [More Information]
Kim, W., Hill, A., Fitzgerald, M., Freeman, M., Evin, G., Garner, B. (2011). Wild Type and Tangier Disease ABCA1 Mutants Modulate Cellular Amyloid-Beta Production Independent of Cholesterol Efflux Activity. Journal of Alzheimer's Disease, 27(2), 441-452. [More Information]

2010

Li, H., Kim, W., Guillemin, G., Hill, A., Evin, G., Garner, B. (2010). Modulation of amyloid precursor protein processing by synthetic ceramide analogues. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1801 (8), 887-895. [More Information]

2009

Kim, W., Chan, S., Hill, A., Guillemin, G., Garner, B. (2009). Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons. Journal of Alzheimer's Disease, 16(1), 121-131. [More Information]

2008

Kim, W., Elliott, D., Kockx, M., Kritharides, L., Rye, K., Jans, D., Garner, B. (2008). Analysis of apolipoprotein E nuclear localization using green fluorescent protein and biotinylation approaches. Biochemical Journal, 409(3), 701-709. [More Information]
Chan, S., Kim, W., Kwok, J., Hill, A., Cappai, R., Rye, K., Garner, B. (2008). ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro. Journal of Neurochemistry, 106(2), 793-804. [More Information]
Glaros, E., Kim, W., Quinn, C., Jessup, W., Rye, K., Garner, B. (2008). Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice. Journal of Lipid Research, 49(2), 324-331. [More Information]
Glaros, E., Kim, W., Rye, K., Shayman, J., Garner, B. (2008). Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice. Journal of Lipid Research, 49(8), 1677-1681. [More Information]

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2007

Glaros, E., Kim, W., Wu, B., Suarna, C., Quinn, C., Rye, K., Stocker, R., Jessup, W., Garner, B. (2007). Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration. Biochemical Pharmacology, 73(9), 1340-1346. [More Information]
Kim, W., Rahmanto, A., Kamili, A., Rye, K., Guillemin, G., Gelissen, I., Jessup, W., Hill, A., Garner, B. (2007). Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid- Peptide Generation. Journal of Biological Chemistry, 282, 2851-2861.

2006

Kim, W., Guillemin, G., Glaros, E., Lim, C., Garner, B. (2006). Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. NeuroReport, 17(9), 891-896. [More Information]
Kim, W., Rahmanto, A., Kamili, A., Rye, K., Guillemin, G., Gelissen, I., Jessup, W., Hill, A., Garner, B. (2006). Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein-E discs and suppression of amyloid-beta peptide generation. Journal of Biological Chemistry, 282(5), 2851-2861. [More Information]

2005

Glaros, E., Kim, W., Quinn, C., Wong, J., Gelissen, I., Jessup, W., Garner, B. (2005). Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. Journal of Biological Chemistry, 280, 24515-24523.

Selected Grants

2022

Common and uncommon lipid dysregulation pathways in MSA and PD brain, Kim W, Fu Y, Dzamko N, Halliday G, Defeat MSA Alliance/Consortium Grant
Are oligodendrocytes the real source of pathologic alpha-synuclein in multiple system atrophy?, Fu Y, Halliday G, Kim W, Hsiao T, Defeat Multiple System Atrophy Australia and New Zealand LTD/Consortium Grant

2018

Mutations in genes causal of white matter disease and dys-regulation of lipid metabolism in frontotemporal dementias, Kwok J, Don A, Don A, Dobson-Stone C, Landin-Romero R, Kim W, Guennewig B, National Health and Medical Research Council (NHMRC)/Project Grants
Lipidomics analysis using serum and CSF from LRRK2-associated Parkinsons disease patients, Dzamko N, Kim W, Michael J Fox Foundation for Parkinsons Research/Research Support

2017

Scott Kim group research funds (Lipids and neurodegenerative diseases), Kim W, Neuroscience Research Australia (NeuRA)/Research Support

2016

COQ2 mutation and methylation dysfunction leading to a-synuclein pathology, Kim W, Halliday G, Multiple System Atrophy Coalition/Seed Grant

In the media

https://www.sbs.com.au/topics/voices/health/article/2016/07/26/pac-man-gene-implicated-alzheimers-disease

Faculty of Medicine and Health

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Associate Professor Woojin Kim

Publications

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Selected Grants

2022

2018

2017

2016

In the media