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New Group
Investigating chemistry
Our work ranges from developing probes for biologically-relevant metal ions to establishing ways to measure biological redox state to help us to better understand diseases.
Our research
There is currently considerable interest in elucidating the relationship between the levels of reactive oxygen species (ROS) and health and disease: while transient increases in ROS levels are necessary for physiological processes, chronically-elevated ROS levels (oxidative stress) are associated with various pathologies. We develop fluorescent sensors for oxidative stress and for hypoxia (low oxygen content), with a focus on achieving sub-cellular resolution and ratiometric output. These sensors are being applied to a range of biological systems by collaborators around the world.
Two of our redox probes can be purchased from Stressmarq Biosciences - please see the following links for more information: NpFR1 and FCR1. For enquiries about other published sensors, please contact Liz.
Fluorescence offers a cheap alternative to mass spectrometry techniques for analysis of complex environments. We are developing sensor arrays to distinguish and quantify chemical species, especially metal ions, in the environment and in biological systems.
Understanding the biochemical composition of cells, organelles and body fluids is essential for uncovering both physiological and pathological processes. This requires the development of chemical tools to complement current imaging and bioanalytical techniques. Multimodal imaging is gaining traction in biomedical and clinical studies as it combines the relative advantages of two or more imaging techniques. We are interested in developing multimodal imaging agents to combine fluorescence imaging with additional modalities. These additional modalities include vibrational spectroscopy, X-ray fluorescence imaging, photoacoustic imaging and positron emission tomography.
This work is funded in part by an ARC Discovery Grant, 2021-2024, with Prof. Hugh Harris University of Adelaide and an NHMRC Ideas Grant, 2023-2026, with Prof. Kay Double,and Prof. Hugh HarrisUniversity of Adelaide and an NHMRC Ideas Grant, 2023-2026, Prof. Steven Meikle, The University of Sydney.
We are part of the ARC Centre of Excellence for Innovations in Peptide and Protein Science, which focusses on discovering new proteins and peptides from Australia's diverse flora and fauna, decoding their biological functions, and developing new proteins and peptides to address challenges in health, agriculture and industry. Our role in this is to develop new fluorescent methods for understanding how and where peptides and proteins accumulate within cells.
Publications
- Hawtrey, T., New EJ, Molecular probes for fluorescent sensing of metal ions in non-mammalian organisms, Current Opinion in Chemical Biology, 2023, 74, 102311
- Asiri, S., Levina, L., New EJ, Lay PA, Investigations of Cellular Copper Metabolism in Ovarian Cancer Cells using a Ratiometric Fluorescent Copper Dye, Journal of Biological Inorganic Chemistry, 2023, 28, 43–55
- Woodhouse RM, Frolows N, Wang G, Hawdon A, Heng E, Wong K, Dansereau LC, Su Y, Adair LD, New EJ, Philp AM, Tan WK, Philp A, Ashe A, Mitochondrial succinate dehydrogenase (SDHA) function is essential for sperm motility and male fertility, iScience, 2023, 25, 105573
- Kikuchi K, Adair LD, Lin J, New EJ, Kaur A, Photochemical Mechanisms of Fluorophores Employed in Single-Molecule Localization Microscopy, Angewandte Chemie, 2022, 62, e202204745
- Bowyer AA, Mai AD, Guo H, New EJ, A pH-based single-sensor array for discriminating metal ions in water, Chemistry – An Asian Journal, 2022, 17, e202200204
- Kaur A, Adair LD, Ball S, New EJ, Sunde M, A fluorescent sensor for super-resolution imaging of prefibrillar and fibrillar amyloid aggregates, Angewandte Chemie, 2022, 61, e202112832
- Marfavi A, Yeo JH, Leslie KG, New EJ, Rendina LM, New boron-based coumarin fluorophores for bioimaging applications, Australian Journal of Chemistry, 2022, 75, 716–724
- Lesani P, Singh G, Lu Z, Mirkhalaf M, Mursi M, New EJ, Zreiqat H, Two-Photon Ratiometric Carbon Dot-Based Probe for Real-Time Intracellular pH Monitoring in 3D Environment, Chemical Engineering Journal, 2022, 433, 133668
- Boumelhem BB, Pilgrim C, Zwicker VE, Kolanowski JL, Yeo JH, Jolliffe KA, New EJ, Day ML, Assinder SJ, Fraser ST, Intracellular flow cytometric lipid analysis: A multiparametric system to assess distinct lipid classes in live cells, Journal of Cell Science, 2022, 135, jcs258322
- Lesani P, Hadi AM, Lu Z, Palomba S, New EJ, Zreiqat H, Design principles and biological applications of red-emissive two-photon carbon dots, Communications Materials, 2021, 2, article 108
- Lin J, Yang K, New EJ, Strategies for organelle targeting of fluorescent probes, Organic and Biomolecular Chemistry, 2021, 19, 9339 - 9357
- Lin J, Graziotto ME, Lay PA, New EJ, A bimodal fluorescence-Raman probe for cellular imaging, Cells, 2021, 10, article 1699
- Graziotto ME, Adair LD, Kaur A, Vérité P, Ball SR, Sunde M, Jacquemin D, New EJ, Versatile naphthalimide tetrazines for fluorogenic bioorthogonal labelling, RSC Chemical Biology, 2021, 2, 1491-1498
- Lesani P, Lu Z, Singh G, Mursi M, Mirkhalaf M, New EJ, Zreiqat H, Influence of carbon dot synthetic parameters on photophysical and biological properties, Nanoscale, 2021, 13, 11138-11149
- Ranieri A, Vezzeli M, Leslie KG, Huang S, Stagni S, Jacquemin D, Jiang H, Hubbard A, Rigamonti L, Watkin E, Ogden MI, New EJ, Massi M, Structure illumination microscopy imaging of lipid vesicles in live bacteria with naphthalimide-appended organometallic complexes, Analyst, 2021, 146, 3818-3822
- Tummanapalli SS, Kuppusamy R, Yeo JH, Kumar N, New EJ, Willcox MDP, The role of nitric oxide in ocular surface physiology and pathophysiology, The Ocular Surface, 2021, 21, 37-51
- Phan TH, Divakarla SK, Yeo JH, Lei Q, Tharkar P, Pansani TN, Leslie KG, Tong M, Coleman VA, Jämting Å, Du Plessis M-D, New EJ, Kalionis B, Demokritou P, Woo H-K, Cho Y-K, Chrzanowski W, New multiscale characterisation methodology for effective determination of isolation- structure-function relationship of extracellular vesicles, Frontiers in Bioengineering and Biotechnology, 2021, Manuscript ID: 669537
- Mitchell L, Shen C, Timmins HC, Park SB, New EJ, A versatile fluorescent sensor array for platinum anti-cancer drug detection in biological fluids, ACS Sensors, 2021, 6, 1261–1269
- Wang Z, Yeo JH, New EJ, Elucidating the roles of Fenton reactants in drug-treated cells using a selective fluorogenic sensor, Analysis & Sensing, 2021, 1, 90-94
- Mitchell L, New EJ, Mahon CS, Macromolecular optical sensor arrays, ACS Applied Polymer Materials, 2021, 3, 506–530
- Zwicker VE, Sergeant GE, New EJ, Jolliffe KA, A colorimetric sensor array for the classification of biologically relevant tri-, di- and mono-phosphates, Organic and Biomolecular Chemistry, 2021, 19, 1017-1021
- Mattison RL, Bowyer AA, New EJ, Small molecule optical sensors for nickel: the quest for a universal nickel receptor, Coordination Chemistry Reviews 2020, 425, Article number: 213522, invited submission
- Trinh N, Jolliffe KA, New EJ, Dual-functionalisation of fluorophores for the preparation of targeted and selective probes, Angewandte Chemie, Int. Ed., 2020, 59, 20290-20301
- Kaur A, New EJ, Sunde M, Strategies for the molecular imaging of amyloid and the value of multi-modal approach, ACS Sensors, 2020, 5, 2268–2282
- Schwartzentruber A, Boschian C, Martins-Lopes F, Myszczynska M, New EJ, Beyrath J, Smeitink J, Ferraiuolo L, Mortiboys H, Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons, Scientific Reports, 2020, 10, Article number: 15485
- Adair LD, Trinh N, Vérité PM, Jacquemin D, Jolliffe KA, New EJ, Synthesis of nitro-aryl functionalised 4-amino-1,8-naphthalimides and their evaluation as fluorescent hypoxia sensors, Chemistry – A European Journal, 2020, 26, 10064-10071.
- Zhu J, Yeo JH, Bowyer AA, Proschogo N, New EJ, Studies of the labile lead pool using a rhodamine-based fluorescent probe, Metallomics, 2020, 12, 644-648
- Thejer BM, Adhikary PP, Teakel SL, Fang J, Weston PA, Gurusinghe S, Anwer AG, Gosnell M, Jazayeri JA, Ludescher M, Gray L-A, Pawlak M, Wallace RH, Pant SD, Wong M, Fischer T, New EJ, Fehm TN, Neubauer H, Goldys EM, Quinn JC, Weston LA, Cahill M, PGRMC1 effects on metabolism, genomic mutation and CpG methylation imply crucial roles in animal biology and disease, BMC Molecular and Cell Biology, 2020, 21, Article number: 26
- Thejer BM, Adhikary PP, Kaur A, Teakel SL, Van Oosterum A, Seth I, Pajic M, Hannan KM, Pavy M, Poh P, Jazayeri JA, Zaw T, Pascovici D, Ludescher M, Pawlak M, Cassano JC, Turnbull L, Jazayeri M, James AC, Coorey CP, Roberts TL, Kinder SJ, Hannan RD, Patrick E, Molloy MP, New EJ, Fehm TN, Neubauer H, Goldys EM, Weston LA, Cahill M, PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth, BMC Molecular and Cell Biology, 2020, 21, Article number: 24
- Sharma H, Tan NK, Trinh N, Yeo JH, New EJ, Pfeffer FM, A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state. Chemical Communications, 2020, 56, 2240 - 2243
- Bowyer AA, Shen C, New EJ, A fluorescent three-sensor array for heavy metals in environmental water sources, Analyst, 2020, 145, 1195 - 1201
- Yang X, Mohseni M, Bas O, Meinert C, New EJ, Castro NJ, Fabrication of multi-material scaffolds via visible-light stereolithography (VL-SL), Tissue Engineering A, 2019, in press
- Leslie KG, Kolanowski JL, Trinh N, Carrara S, Anscomb MD, Yang K, Hogan CF, Jolliffe KA, New EJ, Nicotinamide-appended fluorophores as fluorescent redox sensors. Australian Journal of Chemistry, 2019, 73, 895-902. Invited submission to Women in Australian Chemistry special issue.
- Sharma H, White JM, Lin J, New EJ, Pfeffer FM, A Rhodamine-Nitronaphthalimide Hg(II) Complex for the Simultaneous Detection of Oxidised and Reduced Glutathione. Sensors and Actuators B, 2019, 300, 126825
- Hu MM, Schulze KE, Ghildyal R, Henstridge DC, Kolanowski JL, New EJ, Hong Y, Hsu AC, Hansbro PM, Bogoyevitch MA, Jans DA, Respiratory Syncytial Virus co-opts host mitochondrial function to favour infectious virus production. eLife, 2019, 8:e42448 doi: 10.7554/eLife.42448
- Black HD, Xu W, Horte E, Robertson SI, Britton WJ, Kaur A, New EJ, Witting PK, Chami B, Oehlers SH, The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets. Free Radicals in Biology and Medicine, 2019, 135, 157-166
- Kaur A, New EJ, Bio-inspired small molecule tools for the imaging of redox biology. Accounts of Chemical Research, 2019, 52, 623-632. Invited submission.
- Smith DG, Mitchell L, New EJ, Pattern recognition of toxic metal ions using a single-probe thiocoumarin array. Analyst, 2019, 144, 230-236
- Zwicker VE, Oliveira B, Yeo JH, Fraser ST, Bernardes G, New EJ, Jolliffe KA, A fluorogenic probe for cell surface phosphatidylserine using an intramolecular indicator displacement sensing mechanism. Angewandte Chemie Int. Ed., 2019, 58, 3087-3091. Invited submission to Women in Chemistry special issue.
- Fleming CL, Natoli A, Schreuders J, Devlin M, Yoganantharah P, Gilbert Y, Leslie KG, New EJ, Ashton TD, Pfeffer FM, Highly fluorescent and HDAC6 selective scriptaid analogues. European Journal of Medicinal Chemistry, 2019, 162, 321-333
- Harris M, Kolanowski JL, O’Neill ES, Henoumont C, Laurent S, Parac-Vogt TN, New EJ, Drawing on biology to inspire molecular design: a redox-responsive MRI probe based on Gd(III)-nicotinamide. Chemical Communications, 2018, 54, 12986-12989
- Lim Z, Smith DG, Kolanowski JL, Mattison RL, Knowles JC, Baek S-Y, Chrzanowski W, New EJ, A reversible fluorescent probe for monitoring Ag(I) ions. Journal of the Royal Society Interface, 2018, rsif.2018.0346
- Muellner M, Kaur A, Yang K, New EJ, Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids. Polymer Chemistry, 2018, 9, 3461-3465
- Carney IJ, Kolanowski JL, Lim Z, Chekroun B, Hambley TW, New EJ, A ratiometric iron probe enables investigation of iron distribution within tumour spheroids. Metallomics, 2018, 10, 553-556
- Chong KL, Chalmers BA, Cullen JK, Kaur A, Kolanowski JK, Morrow BJ, Fairfull-Smith K, Lavin MJ, Barnett NL, New EJ, Murphy MP, Bottle SE, Pro-fluorescent mitochondria-targeted real-time responsive redox probes synthesised from carboxy isoindoline nitroxides: Sensitive probes of mitochondrial redox status in cells. Free Radicals in Biology and Medicine, 2018, 128, 97-110. Personal invitation for special issue on fluorescent and chemiluminescent approaches.
- Leslie KG, Jacquemin D, New EJ, Jolliffe KA, Expanding the breadth of 4-amino-1,8-naphthalimide photophysical properties through substitution of the naphthalimide core. Chemistry – A European Journal, 2018, 24, 5569-5573.
- Renfrew AK, O’Neill ES, Hambley TW, New EJ, Harnessing the properties of cobalt coordination complexes for biological application. Coordination Chemistry Reviews, 2018, 375, 221-233. Invited submission.
- Yang K, Leslie KG, Kim SY, Kalionis B, Chrzanowski W, Jolliffe KA, New EJ, Tailoring the properties of a hypoxia-responsive 1,8-naphthalimide for imaging applications. Organic and Biomolecular Chemistry, 2018, 16, 619-624
- New EJ, Wimmer VC, Hare DJ, Promises and pitfalls of metal imaging in biology. Cell Chemical Biology, 2018, 25, 7-18
- Kolanowski JL, Liu F, New EJ, Fluorescent probes for the simultaneous detection of multiple analytes in biology. Chemical Society Reviews, 2018, 47, 195-208. Invited submission for emerging researchers special issue
- Kolanowski JL, Dawson LK, Mitchell L, Lim Z, Graziotto ME, Filipek WK, Hambley TW, New EJ, A fluorescent probe for investigating metabolic stability of active transplatin analogues. Sensors and Actuators B: Chemical, 2018, 255, 2721-2724
- Wright PJ, Kolanowski JL, Filipek W, Moore EG, Stagnid S, New EJ, Massi M, Versatility of terpyridine functionalised aryl tetrazoles: photophysical properties, ratiometric sensing of zinc cations and sensitisation of lanthanide luminescence. European Journal of Inorganic Chemistry, 2017, 5260-5270
- Smith DG, Topolnicki IL, Zwicker ZE, Jolliffe KA and New EJ, Fluorescent Sensing Arrays for Cations and Anions. Analyst, 2017, 142, 3549-3563
- Graziotto ME, Akerfeldt MC, Gunn AP, Yang K, Somerville MV, Coleman NV, Roberts BR, Hambley TW, New EJ, The influence of the ethane-1,2-diamine ligand on the activity of a monofunctional platinum complex. Journal of Inorganic Biochemistry, 2017, 177, 328-334
- O’Neill ES, Kaur A, Bishop DP, Shishmarev D, Kuchel PW, Grieve SM, Figtree GA, Renfrew AK, Bonnitcha PD, New EJ, Hypoxia-responsive cobalt complexes in tumor spheroids: LA-ICP-MS and MRI studies. Inorganic Chemistry, 2017, 56, 9860-9868
- Wu A, Kolanowski JL, Boumelhem BB, Lee R, Kaur A, Fraser ST, New EJ, Rendina LM, A new carborane-containing fluorophore as a stain of cellular lipid droplets. Chemistry – An Asian Journal, 2017, 12, 1704-1708
- Akerfeldt MC, Tran CM-N, Shen C, Hambley TW, New EJ, Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells. Journal of Biological Inorganic Chemistry, 2017, 22, 765-774
- O’Neill ES, Kolanowski JL, Bonnitcha PD, New EJ, A cobalt(II) complex with unique paraSHIFT responses to anions. Chemical Communications, 2017, 53, 3571-3574
- Yang K, Kolanowski JL, New EJ, Mitochondrially targeted fluorescent redox sensors, Interface Focus, 2017, 20160105
- Shen C, Kolanowski JL, Tran C, Kaur A, Akerfeldt MC, Rahme MS, Hambley TW, New EJ, A ratiometric fluorescent sensor for the mitochondrial copper pool, Metallomics, 2016, 8, 915-919
- Krishnamoorthy L, Cortruvo JA, Chan J, Kaluarachchi H, Muchenditsi A, Pendyala VS, Jia S, Aron AT, Ackerman CM, Vander Wal MN, Guan T, Smaga LP, Farhi SL, New EJ, Lutsenko S, Chang CJ, Copper regulates cyclic-AMP-dependent lipolysis, Nature Chemical Biology, 2016, 12, 586–592
- Smith DG, Sajid N, Rehn S, Chandramohan R, Carney IJ, Khan MA, New EJ, A library-screening approach to developing a fluorescent sensing array for the detection of metal ions, Analyst, 2016, 141, 4608-4613
- Wilkinson S, Sheedy T, New EJ, Synthesis and characterization of metal complexes with Schiff base ligands. Journal of Chemical Education, 2016, 93, 351-354
- New EJ. Harnessing the Potential of Small Molecule Intracellular Fluorescent Sensors, ACS Sensors, 2016, 1, 328–333 (invited submission)
- O’Neill ES, Kolanowski JL, Yin GH, Broadhouse KM, Grieve SM, Renfrew AK, Bonnitcha PD, New EJ. Reversible magnetogenic cobalt complexes. RSC Advances, 2016, 6, 30021-30027
- Hare DJ, New EJ. On the outside looking in: redefining the role of analytical chemistry in the biosciences. Chemical Communications, 2016, 52, 8918-8934. (invited submission to emerging investigator issue)
- Kaur A, Jankowska K, Pilgrim C, Fraser ST, New EJ. Studies of hematopoietic cell differentiation with a ratiometric and reversible sensor of mitochondrial reactive oxygen species. Antioxidants and Redox Signaling, 2016, 24, 667-79. (invited submission)
- Kolanowski JL, Kaur A, New EJ. Selective and reversible approaches towards imaging redox signaling using small molecule probes. Antioxidants and Redox Signaling, 2016, 24, 713-730. (invited review)
- Kaur A, Kolanowski JL, New EJ. Reversible fluorescent probes of biological redox state. Angewandte Chemie, 2016, 55, 1602–1613.
- Hare DJ, New EJ, de Jonge MD, McColl G. Imaging metals in biology: Balancing sensitivity, selectivity and spatial resolution. Chemical Society Reviews, 2015, 44, 5941-5958. (awarded best review of 2015, Florey Institute)
- Kaur A, Haghighatbin MA, Hogan CF, New EJ. A FRET-based ratiometric redox probe for detecting oxidative stress by confocal microscopy, FLIM and flow cytometry. Chemical Communications, 2015, 51, 10510-10513.
- Kaur A, Brigden KWL, Cashman TF, Fraser ST and New EJ. Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells. Organic and Biomolecular Chemistry, 2015, 13, 6686-6689. Highlighted as a “Hot Article”
- Shen C, Harris BDW, Dawson LJ, Charles KA, Hambley TW and New EJ. Fluorescent sensing of monofunctional platinum species. Chemical Communications, 2015, 51, 6312-6314.
- Shen C, New EJ. What has fluorescent sensing told us about copper and brain malfunction? Metallomics, 2015, 7, 56-65.
- Eljack N, Ma H, Drucker J, Shen C, Hambley TW, New EJ, Friedrich T, Clarke RC, Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin. Metallomics, 2014, 6, 2126-2133.
- Yeow J, Kaur A, Anscomb MD, New EJ, A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes, Chem Commun., 2014, 50, 8181-8184.
- Shen C, New EJ. Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents, Curr Opin Chem Biol., 2013, 17, 158-166.
- New EJ. Tools to study distinct metal pools in biology, Dalton Trans., 2013, 42, 3210-3219.
Our people
- Professor Elizabeth New
- Dr Liam Adair, Postdoctoral Researcher
- Dr Tom Hawtrey, Postdoctoral Researcher
- Dr Leila Hill, Postdoctoral Researcher
- Nian Kee Tan, PhD Student
- Hazel Chan, PhD Student
- Haobo Guo, PhD Student
- Karandeep Grover, PhD Student
- Pramsak Patawanich, PhD Student
- Jukkrit Nootem, PhD Student
- Mohammed siddeek fathima Nusra, PhD Student
- Kalpana Parajuli Baral, PhD Student
- Aedena Raquel Remy, PhD Student
- Alla Koblova, PhD Student
- Muhammad Tahir Waseem, PhD Student
- Kai Kikuchi, PhD Student
- Guanming Di, Honours Student
Postdoctoral researchers
- Mia Akerfeldt
- Marcus Graziotto
- Karolina Jankowska
- Jacek Kolanowski
- Zelong Lim
- Clare Mahon
- David Smith
- Jia Hao Yeo
PhD students
- Natalie Trinh
- Amy Bowyer
- Joy Ghrayche
- Marcus Graziotto
- Paris Jeffcoat
- Amandeep Kaur
- Jiarun (Veronica) Lin
- Rebecca Mattison
- Linda Mitchell
- Edward O’Neill
- Clara Shen
- Natalie Trinh
- Zhanlong Wang
- Kylie Yang
- Jianping Zhu
- Eddie Zwicker
MSc students
- Kathryn Leslie
Honours students
- Matthew Anscomb
- Amy Bowyer
- Luc Cambon
- Isaac Carney
- Madeleine Carr
- Abir Das
- Yining Du
- Joy Ghrayche
- Marcus Graziotto
- Paris Jeffcoat
- Vivian Lee
- Kathryn Leslie
- Jiarun (Veronica) Lin
- Linda Mitchell
- Eliot Salmon
- Clara Shen
- Maggie Tong
- Angela Torrisi
- Carmen Tran
- Natalie Trinh
- Kylie Yang
- Jonathan Yeow
Visiting researchers
- Benjamin Chekroun
- Lucy Dawson
- Laura Gauthier
- Agathe Guyetand
- Michael Harris
- Pooria Lesani
- Monika Lesiów
- Alessio Orsino
- Anna Ranieri
- Naveed Sajid
- Claudia Solari
- Aorada Sripunya
- Lisanne van Oppen
- Xin Yang
Opportunities
Undergraduate students
Dalyell students - please enquire about possible projects.
Summer vacation scholarships - are a great way to see what research is all about.
Honours students - several projects are available each year.
Postgraduate students
Please contact Liz if you are interested in a PhD in the New group. You should provide an up-to-date CV including names of two referees that you are happy for Liz to contact, and a cover letter explaining your motivation.
For international students, details of possible scholarships can be found here.
Postdoctoral researchers
Liz does not currently have funding for a postdoctoral researcher. You are welcome to contact Liz if you are interested in applying for a research fellowship to work in the group.
Elizabeth New
Professor
Address
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School of Chemistry Building (F11) The University of Sydney NSW, 2006