People_

Dr Mark Graham

Senior Lecturer, Faculty of Medicine and Health
Group Leader, Children's Medical Research Institute

Phone

+61 2 8865 2989

Email

mark.graham@sydney.edu.au

Details

Member of the Brain and Mind Centre

Websites

Honours in Medical Science at Westmead

PhD at the Children's Medical Research Institute

Research interests

Dr Graham’s overall aim is to understand the molecular basis of brain function and neurological diseases. In particular, his group is focusing on proteins involved in synaptic transmission, how they interact, mapping cellular signalling events triggered by neuronal activity and identifying regulatory mechanisms that could potentially be exploited by therapeutics to treat diseases of synaptic transmission, e.g. epilepsy, autism, schizophrenia, bipolar disorder.

The Synapse Proteomics group uses cutting edge technology and basic biochemical and molecular biology techniques. In particular, Dr Graham studies phosphorylation-based cellular signalling as means to determine critical cellular pathways and biomarkers. Screens are followed by biochemical analysis and functional assays to discover new mechanisms and their consequences for synaptic plasticity and neurological diseases.

Themes

Cancer, Neurosciences and Mental Health

Keywords

Biochemistry, Cancer, Cell biology, Neurosciences, Proteomics

Approaches

Cellular Signalling, Cellular/Molecular, Protein Targetting/Trafficking

Current research students

Project title	Research student
Integrative omics: A novel approach to unravelling the complex panoramic landscape of Rett syndrome	Jasmeen ISSAR

Publications

By Type

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Book Chapters

Engholm-Keller, K., Bache, N., Rao, S., Wark, J., Larsen, M., Robinson, P., Graham, M. (2018). Affinity Proteomics for Interactome and Phosphoproteome Screening in Synaptosomes. In Kathryn M. Murphy (Eds.), Synaptosomes, (pp. 165-191). New York: Springer. [More Information]
Graham, M., Lavin, M., Kozlov, S. (2017). Identification of ATM Protein Kinase Phosphorylation Sites by Mass Spectrometry. In Sergei V. Kozlov (Eds.), ATM Kinase: Methods and Protocols, (pp. 127-144). New York: Springer. [More Information]

Journals

Huang, H., van Waardenberg, A., Graham, M., Anggono, V., Widagdo, J. (2023). Global quantitative proteomic analysis of aged mouse hippocampus. Proteomics. [More Information]
Yasa, J., Reed, C., Bournazos, A., Evesson, F., Pang, I., Graham, M., Wark, J., Nijagal, B., Kwan, K., Kwiatkowski, T., Cooper, S., Lemckert, F., et al (2023). Minimal expression of dysferlin prevents development of dysferlinopathy in dysferlin exon 40a knockout mice. Acta Neuropathologica Communications, 11(1). [More Information]
Hanafy, A., Steinlein, P., Pitsch, J., Silva, M., Vana, N., Becker, A., Graham, M., Schoch, S., Lamprecht, A., Dietrich, D. (2023). Subcellular analysis of blood-brain barrier function by micro-impalement of vessels in acute brain slices. Nature Communications, 14(1). [More Information]
Longfield, S., Mollazade, M., Wallis, T., Gormal, R., Joensuu, M., Wark, J., van Waardenberg, A., Small, C., Graham, M., Meunier, F., et al (2023). Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles. Nature Communications, 14(1). [More Information]
Müller, J., Betzin, J., Santos-Tejedor, J., Mayer, A., Oprisoreanu, A., Engholm-Keller, K., Paulußen, I., Gulakova, P., McGovern, T., Gschossman, L., Wark, J., Graham, M., et al (2022). A presynaptic phosphosignaling hub for lasting homeostatic plasticity. Cell Reports, 39(3), 110696. [More Information]
Royero, P., Quatraccioni, A., Früngel, R., Silva, M., Bast, A., Ulas, T., Beyer, M., Opitz, T., Schultze, J., Graham, M., et al (2022). Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase. Cell Reports, 41(10). [More Information]
Fernando, M., Lee, S., Wark, J., Xiao, D., Lim, B., O'Hara-Wright, M., Kim, H., Smith, G., Wong, T., Teber, E., Yang, P., Graham, M., Gonzalez Cordero, A., et al (2022). Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin. Stem Cell Reports, 17(6), 1476-1492. [More Information]
Almazi, J., Alomari, M., Belov, L., Best, O., Shen, Y., Graham, M., Mulligan, S., Christopherson, R. (2022). Fludarabine nucleoside induces major changes in the p53 interactome in human B-lymphoid cancer cell lines. Nucleosides, Nucleotides and Nucleic Acids: An International Journal for Rapid Communication, 41(3), 314-320. [More Information]
Fan, X., Masamsetti, V., Sun, J., Engholm-Keller, K., Osteil, P., Studdert, J., Graham, M., Fossat, N., Tam, P. (2021). TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. eLife, 10, e62873-1-e62873-33. [More Information]
Ruiter, M., Houy, S., Engholm-Keller, K., Graham, M., Sorensen, J. (2020). SNAP-25 phosphorylation at Ser187 is not involved in Ca2+ or phorbolester-dependent potentiation of synaptic release. Molecular and Cellular Neuroscience, 102, 103452. [More Information]
Fan, X., Waardenberg, A., Demuth, M., Osteil, P., Sun, J., Loebel, D., Graham, M., Tam, P., Fossat, N. (2020). Twist1 homodimers and heterodimers orchestrate lineage-specific differentiation. Molecular and Cellular Biology, 40(11), 1-20. [More Information]
Moshkanbaryans, L., Chan, L., Engholm-Keller, K., Wark, J., Robinson, P., Graham, M. (2019). The interaction of assembly protein AP180 and clathrin is inhibited by multi-site phospho-mimetics. Neurochemistry International, 129, 1-11. [More Information]
Engholm-Keller, K., Waardenberg, A., Muller, J., Wark, J., Fernando, R., Arthur, J., Robinson, P., Dietrich, D., Schoch, S., Graham, M. (2019). The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation. PLoS Biology, 17(3), 1-46. [More Information]
Moshkanbaryans, L., Xue, J., Wark, J., Robinson, P., Graham, M. (2016). A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly. PloS One, 11(8), 1-18. [More Information]
Kozlov, S., Waardenberg, A., Engholm-Keller, K., Arthur, J., Graham, M., Lavin, M. (2016). Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen. Molecular and Cellular Proteomics, 15(3), 1032-1047. [More Information]
Yeo, A., Becherel, O., Luff, J., Graham, M., Richard, D., Lavin, M. (2015). Senataxin controls meiotic silencing through ATR activation and chromatin remodeling. Cell Discovery, 1, 1-20. [More Information]
Moshkanbaryans, L., Chan, L., Graham, M. (2014). The Biochemical Properties and Functions of CALM and AP180 in Clathrin Mediated Endocytosis. Membranes, 4(3), 388-413. [More Information]
Chan, L., Moshkanbaryans, L., Xue, J., Graham, M. (2014). The ~ 16 kDa C-terminal sequence of clathrin assembly protein AP180 is essential for efficient clathrin binding. PloS One, 9(10), 1-13. [More Information]
Parker, B., Thaysen-Andersen, M., Solis, N., Scott, N., Larsen, M., Graham, M., Packer, N., Cordwell, S. (2013). Site-Specific Glycan-Peptide Analysis for Determination of N-Glycoproteome Heterogeneity. Journal of Proteome Research, 12(12), 5791-8000. [More Information]
Palmisano, G., Parker, B., Engholm-Keller, K., Lendal, S., Kulej, K., Schulz, M., Schwammle, V., Graham, M., Saxtorph, H., Cordwell, S., et al (2012). A novel method for the simultaneous enrichment, identification, and quantification of phosphopeptides and sialylated glycopeptides applied to a temporal profile of mouse brain development. Molecular and Cellular Proteomics, 11(11), 1191-1202. [More Information]
Bolderson, E., Savage, K., Mahen, R., Pisupati, V., Graham, M., Richard, D., Robinson, P., Venkitaraman, A., Khanna, K. (2012). Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1B (HP1-B) mobilization and DNA repair in heterochromatin. Journal of Biological Chemistry, 287(33), 28122-28131. [More Information]
Quan, A., Xue, J., Wielens, J., Smillie, K., Anggono, V., Parker, M., Cousin, M., Graham, M., Robinson, P. (2012). Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proceedings of the National Academy of Sciences of the United States of America, 109(10), 3760-3765. [More Information]
Graham, M., Stone, R., Robinson, P., Payne, R. (2012). Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked beta-N-acetylglucosaminyl-6-phosphate modification. Organic and Biomolecular Chemistry, 10(13), 2545-2551. [More Information]
Graham, M., Thaysen-Andersen, M., Bache, N., Craft, G., Larsen, M., Packer, N., Robinson, P. (2011). A Novel Post-translational Modification in Nerve Terminals: O-Linked N-Acetylglucosamine Phosphorylation. Journal of Proteome Research, 10(6), 2725-2733. [More Information]
Kozlov, S., Graham, M., Jakob, B., Tobias, F., Kijas, A., Tanuji, M., Chen, P., Robinson, P., Taucher-Scholz, G., Suzuki, K., et al (2011). Autophosphorylation and ATM activation: additional sites add to the complexity. Journal of Biological Chemistry, 286(11), 9107-9119. [More Information]
Xue, J., Graham, M., Novelle, A., Sue, N., Gray, N., McNiven, M., Smillie, K., Cousin, M., Robinson, P. (2011). Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis. Journal of Biological Chemistry, 286(35), 30295-30303. [More Information]
Chircop (nee Fabbro), M., Sarcevic, B., Larsen, M., Malladi, C., Chau, N., Zavortink, M., Smith, C., Quan, A., Anggono, V., Hains, P., Graham, M., Robinson, P. (2011). Phosphorylation of dynamin II at serine-764 is associated with cytokinesis. Biochimica et Biophysica Acta, 1813 (10), 1689-1699. [More Information]
Chan, L., Hansra, G., Robinson, P., Graham, M. (2010). Differential Phosphorylation of Dynamin I Isoforms in Subcellular Compartments Demonstrates the Hidden Complexity of Phosphoproteomes. Journal of Proteome Research, 9(8), 4028-4037. [More Information]
Baker, M., Smith, N., Hetherington, L., Taubman, K., Graham, M., Robinson, P., Aitken, R. (2010). Label-Free Quantitation of Phosphopeptide Changes During Rat Sperm Capacitation. Journal of Proteome Research, 9(2), 718-729. [More Information]
O'dell, L., Chau, N., Mariana, A., Graham, M., Robinson, P., McCluskey, A. (2009). Azido and Diazarinyl Analogues of Bis-Tyrphostin as Asymmetrical Inhibitors of Dynamin GTPase. ChemMedChem: chemistry enabling drug discovery, 4(7), 1182-1188. [More Information]
Chircop (nee Fabbro), M., Oakes, V., Graham, M., Ma, M., Smith, C., Robinson, P., Khanna, K. (2009). The actin-binding and bundling protein, EPLIN, is required for cytokinesis. Cell Cycle, 8(5), 757-764. [More Information]
Craft, G., Graham, M., Bache, N., Larsen, M., Robinson, P. (2008). The in vivo phosphorylation sites in multiple isoforms of amphiphysin I from rat brain nerve terminals. Molecular and Cellular Proteomics, 7(6), 1146-1161. [More Information]
Cohen, S., Graham, M., Lovrecz, G., Bache, N., Robinson, P., Reddel, R. (2007). Protein composition of catalytically active human telomerase from immortal cells. Science, 315(5820), 1850-1853. [More Information]
Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007). Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry, 46(40), 11279-11290. [More Information]
Graham, M., Kilby, D., Firth, S., Robinson, P., Baxter, R. (2007). The in vivo phosphorylation and glycosylation of human insulin-like growth factor binding protein-5. Molecular and Cellular Proteomics, 6(8), 1392-1405. [More Information]
Graham, M., Anggono, V., Bache, N., Larsen, M., Craft, G., Robinson, P. (2007). The in vivo phosphorylation sites of rat brain dynamin I. Journal of Biological Chemistry, 282(20), 14695-14707. [More Information]
Acevedo, K., Li, R., Soo, P., Suryadinata, R., Sarcevic, B., Valova, V., Graham, M., Robinson, P., Bernard, O. (2007). The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Experimental Cell Research, 313(20), 4091-4106. [More Information]
Kozlov, S., Graham, M., Peng, C., Chen, P., Robinson, P., Lavin, M. (2006). Involvement of novel autophosphorylation sites in ATM activation. EMBO Journal, 25(15), 3504-3514. [More Information]
Anggono, V., Smillie, K., Graham, M., Valova, V., Cousin, M., Robinson, P. (2006). Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nature Neuroscience, 9(6), 752-760. [More Information]
Chircop (nee Fabbro), M., Zhou, B., Takahashi, M., Sarcevic, B., Lal, P., Graham, M., Gabrielli, B., Robinson, P., Nigg, E., Ono, Y., et al (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental Cell, 9(4), 477-488. [More Information]
Hill, T., O'dell, L., Edwards, J., Graham, M., McGeachie, A., Rusak, J., Quan, A., Abagyan, R., Scott, J., Robinson, P., et al (2005). Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins. Journal of Medicinal Chemistry, 48(24), 7781-7788. [More Information]
Larsen, M., Graham, M., Robinson, P., Roepstorff, P. (2004). Improved Detection Of Hydrophilic Phosphopeptides Using Graphite Powder Microcolumns And Mass Spectrometry: Evidence For In Vivo Doubly Phosphorylated Dynamin I And Dynamin Iii. Molecular and Cellular Proteomics, 3(5), 456-465. [More Information]
Graham, M., Ruma-Haynes, P., Capes-Davis, A., Dunn, J., Tan, T., Valova, V., Robinson, P., Jeffrey, P. (2004). Multisite Phosphorylation Of Doublecortin By Cyclin-Dependent Kinase 5. Biochemical Journal, 381(2), 471-481. [More Information]
Xue, J., Milburn, P., Hanna, B., Graham, M., Rostas, J., Robinson, P. (2004). Phosphorylation Of Septin 3 On Ser-91 By Cgmp-Dependent Protein Kinase-I In Nerve Terminals. Biochemical Journal, 381(3), 753-760. [More Information]
Tan, T., Valova, V., Malladi, C., Graham, M., Berven, L., Jupp, O., Hansra, G., McClure, S., Sarcevic, B., Boadle, R., Robinson, P., et al (2003). Cdk5 is essential for synaptic vesicle endocytosis. Nature Cell Biology, 5(8), 701-710. [More Information]

show 42 more

By Year

Expand all

2023

Huang, H., van Waardenberg, A., Graham, M., Anggono, V., Widagdo, J. (2023). Global quantitative proteomic analysis of aged mouse hippocampus. Proteomics. [More Information]
Yasa, J., Reed, C., Bournazos, A., Evesson, F., Pang, I., Graham, M., Wark, J., Nijagal, B., Kwan, K., Kwiatkowski, T., Cooper, S., Lemckert, F., et al (2023). Minimal expression of dysferlin prevents development of dysferlinopathy in dysferlin exon 40a knockout mice. Acta Neuropathologica Communications, 11(1). [More Information]
Hanafy, A., Steinlein, P., Pitsch, J., Silva, M., Vana, N., Becker, A., Graham, M., Schoch, S., Lamprecht, A., Dietrich, D. (2023). Subcellular analysis of blood-brain barrier function by micro-impalement of vessels in acute brain slices. Nature Communications, 14(1). [More Information]
Longfield, S., Mollazade, M., Wallis, T., Gormal, R., Joensuu, M., Wark, J., van Waardenberg, A., Small, C., Graham, M., Meunier, F., et al (2023). Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles. Nature Communications, 14(1). [More Information]

show 1 more

2022

Müller, J., Betzin, J., Santos-Tejedor, J., Mayer, A., Oprisoreanu, A., Engholm-Keller, K., Paulußen, I., Gulakova, P., McGovern, T., Gschossman, L., Wark, J., Graham, M., et al (2022). A presynaptic phosphosignaling hub for lasting homeostatic plasticity. Cell Reports, 39(3), 110696. [More Information]
Royero, P., Quatraccioni, A., Früngel, R., Silva, M., Bast, A., Ulas, T., Beyer, M., Opitz, T., Schultze, J., Graham, M., et al (2022). Circuit-selective cell-autonomous regulation of inhibition in pyramidal neurons by Ste20-like kinase. Cell Reports, 41(10). [More Information]
Fernando, M., Lee, S., Wark, J., Xiao, D., Lim, B., O'Hara-Wright, M., Kim, H., Smith, G., Wong, T., Teber, E., Yang, P., Graham, M., Gonzalez Cordero, A., et al (2022). Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin. Stem Cell Reports, 17(6), 1476-1492. [More Information]
Almazi, J., Alomari, M., Belov, L., Best, O., Shen, Y., Graham, M., Mulligan, S., Christopherson, R. (2022). Fludarabine nucleoside induces major changes in the p53 interactome in human B-lymphoid cancer cell lines. Nucleosides, Nucleotides and Nucleic Acids: An International Journal for Rapid Communication, 41(3), 314-320. [More Information]

show 1 more

2021

Fan, X., Masamsetti, V., Sun, J., Engholm-Keller, K., Osteil, P., Studdert, J., Graham, M., Fossat, N., Tam, P. (2021). TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. eLife, 10, e62873-1-e62873-33. [More Information]

2020

Ruiter, M., Houy, S., Engholm-Keller, K., Graham, M., Sorensen, J. (2020). SNAP-25 phosphorylation at Ser187 is not involved in Ca2+ or phorbolester-dependent potentiation of synaptic release. Molecular and Cellular Neuroscience, 102, 103452. [More Information]
Fan, X., Waardenberg, A., Demuth, M., Osteil, P., Sun, J., Loebel, D., Graham, M., Tam, P., Fossat, N. (2020). Twist1 homodimers and heterodimers orchestrate lineage-specific differentiation. Molecular and Cellular Biology, 40(11), 1-20. [More Information]

2019

Moshkanbaryans, L., Chan, L., Engholm-Keller, K., Wark, J., Robinson, P., Graham, M. (2019). The interaction of assembly protein AP180 and clathrin is inhibited by multi-site phospho-mimetics. Neurochemistry International, 129, 1-11. [More Information]
Engholm-Keller, K., Waardenberg, A., Muller, J., Wark, J., Fernando, R., Arthur, J., Robinson, P., Dietrich, D., Schoch, S., Graham, M. (2019). The temporal profile of activity-dependent presynaptic phospho-signalling reveals long-lasting patterns of poststimulus regulation. PLoS Biology, 17(3), 1-46. [More Information]

2018

Engholm-Keller, K., Bache, N., Rao, S., Wark, J., Larsen, M., Robinson, P., Graham, M. (2018). Affinity Proteomics for Interactome and Phosphoproteome Screening in Synaptosomes. In Kathryn M. Murphy (Eds.), Synaptosomes, (pp. 165-191). New York: Springer. [More Information]

2017

Graham, M., Lavin, M., Kozlov, S. (2017). Identification of ATM Protein Kinase Phosphorylation Sites by Mass Spectrometry. In Sergei V. Kozlov (Eds.), ATM Kinase: Methods and Protocols, (pp. 127-144). New York: Springer. [More Information]

2016

Moshkanbaryans, L., Xue, J., Wark, J., Robinson, P., Graham, M. (2016). A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly. PloS One, 11(8), 1-18. [More Information]
Kozlov, S., Waardenberg, A., Engholm-Keller, K., Arthur, J., Graham, M., Lavin, M. (2016). Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics Screen. Molecular and Cellular Proteomics, 15(3), 1032-1047. [More Information]

2015

Yeo, A., Becherel, O., Luff, J., Graham, M., Richard, D., Lavin, M. (2015). Senataxin controls meiotic silencing through ATR activation and chromatin remodeling. Cell Discovery, 1, 1-20. [More Information]

2014

Moshkanbaryans, L., Chan, L., Graham, M. (2014). The Biochemical Properties and Functions of CALM and AP180 in Clathrin Mediated Endocytosis. Membranes, 4(3), 388-413. [More Information]
Chan, L., Moshkanbaryans, L., Xue, J., Graham, M. (2014). The ~ 16 kDa C-terminal sequence of clathrin assembly protein AP180 is essential for efficient clathrin binding. PloS One, 9(10), 1-13. [More Information]

2013

Parker, B., Thaysen-Andersen, M., Solis, N., Scott, N., Larsen, M., Graham, M., Packer, N., Cordwell, S. (2013). Site-Specific Glycan-Peptide Analysis for Determination of N-Glycoproteome Heterogeneity. Journal of Proteome Research, 12(12), 5791-8000. [More Information]

2012

Palmisano, G., Parker, B., Engholm-Keller, K., Lendal, S., Kulej, K., Schulz, M., Schwammle, V., Graham, M., Saxtorph, H., Cordwell, S., et al (2012). A novel method for the simultaneous enrichment, identification, and quantification of phosphopeptides and sialylated glycopeptides applied to a temporal profile of mouse brain development. Molecular and Cellular Proteomics, 11(11), 1191-1202. [More Information]
Bolderson, E., Savage, K., Mahen, R., Pisupati, V., Graham, M., Richard, D., Robinson, P., Venkitaraman, A., Khanna, K. (2012). Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1B (HP1-B) mobilization and DNA repair in heterochromatin. Journal of Biological Chemistry, 287(33), 28122-28131. [More Information]
Quan, A., Xue, J., Wielens, J., Smillie, K., Anggono, V., Parker, M., Cousin, M., Graham, M., Robinson, P. (2012). Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proceedings of the National Academy of Sciences of the United States of America, 109(10), 3760-3765. [More Information]
Graham, M., Stone, R., Robinson, P., Payne, R. (2012). Synthesis and protein binding studies of a peptide fragment of clathrin assembly protein AP180 bearing an O-linked beta-N-acetylglucosaminyl-6-phosphate modification. Organic and Biomolecular Chemistry, 10(13), 2545-2551. [More Information]

show 1 more

2011

Graham, M., Thaysen-Andersen, M., Bache, N., Craft, G., Larsen, M., Packer, N., Robinson, P. (2011). A Novel Post-translational Modification in Nerve Terminals: O-Linked N-Acetylglucosamine Phosphorylation. Journal of Proteome Research, 10(6), 2725-2733. [More Information]
Kozlov, S., Graham, M., Jakob, B., Tobias, F., Kijas, A., Tanuji, M., Chen, P., Robinson, P., Taucher-Scholz, G., Suzuki, K., et al (2011). Autophosphorylation and ATM activation: additional sites add to the complexity. Journal of Biological Chemistry, 286(11), 9107-9119. [More Information]
Xue, J., Graham, M., Novelle, A., Sue, N., Gray, N., McNiven, M., Smillie, K., Cousin, M., Robinson, P. (2011). Calcineurin Selectively Docks with the Dynamin Ixb Splice Variant to Regulate Activity-dependent Bulk Endocytosis. Journal of Biological Chemistry, 286(35), 30295-30303. [More Information]
Chircop (nee Fabbro), M., Sarcevic, B., Larsen, M., Malladi, C., Chau, N., Zavortink, M., Smith, C., Quan, A., Anggono, V., Hains, P., Graham, M., Robinson, P. (2011). Phosphorylation of dynamin II at serine-764 is associated with cytokinesis. Biochimica et Biophysica Acta, 1813 (10), 1689-1699. [More Information]

show 1 more

2010

Chan, L., Hansra, G., Robinson, P., Graham, M. (2010). Differential Phosphorylation of Dynamin I Isoforms in Subcellular Compartments Demonstrates the Hidden Complexity of Phosphoproteomes. Journal of Proteome Research, 9(8), 4028-4037. [More Information]
Baker, M., Smith, N., Hetherington, L., Taubman, K., Graham, M., Robinson, P., Aitken, R. (2010). Label-Free Quantitation of Phosphopeptide Changes During Rat Sperm Capacitation. Journal of Proteome Research, 9(2), 718-729. [More Information]

2009

O'dell, L., Chau, N., Mariana, A., Graham, M., Robinson, P., McCluskey, A. (2009). Azido and Diazarinyl Analogues of Bis-Tyrphostin as Asymmetrical Inhibitors of Dynamin GTPase. ChemMedChem: chemistry enabling drug discovery, 4(7), 1182-1188. [More Information]
Chircop (nee Fabbro), M., Oakes, V., Graham, M., Ma, M., Smith, C., Robinson, P., Khanna, K. (2009). The actin-binding and bundling protein, EPLIN, is required for cytokinesis. Cell Cycle, 8(5), 757-764. [More Information]

2008

Craft, G., Graham, M., Bache, N., Larsen, M., Robinson, P. (2008). The in vivo phosphorylation sites in multiple isoforms of amphiphysin I from rat brain nerve terminals. Molecular and Cellular Proteomics, 7(6), 1146-1161. [More Information]

2007

Cohen, S., Graham, M., Lovrecz, G., Bache, N., Robinson, P., Reddel, R. (2007). Protein composition of catalytically active human telomerase from immortal cells. Science, 315(5820), 1850-1853. [More Information]
Oganesian, L., Graham, M., Robinson, P., Bryan, T. (2007). Telomerase Recognizes G-Quadruplex and Linear DNA as Distinct Substrates. Biochemistry, 46(40), 11279-11290. [More Information]
Graham, M., Kilby, D., Firth, S., Robinson, P., Baxter, R. (2007). The in vivo phosphorylation and glycosylation of human insulin-like growth factor binding protein-5. Molecular and Cellular Proteomics, 6(8), 1392-1405. [More Information]
Graham, M., Anggono, V., Bache, N., Larsen, M., Craft, G., Robinson, P. (2007). The in vivo phosphorylation sites of rat brain dynamin I. Journal of Biological Chemistry, 282(20), 14695-14707. [More Information]
Acevedo, K., Li, R., Soo, P., Suryadinata, R., Sarcevic, B., Valova, V., Graham, M., Robinson, P., Bernard, O. (2007). The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Experimental Cell Research, 313(20), 4091-4106. [More Information]

show 2 more

2006

Kozlov, S., Graham, M., Peng, C., Chen, P., Robinson, P., Lavin, M. (2006). Involvement of novel autophosphorylation sites in ATM activation. EMBO Journal, 25(15), 3504-3514. [More Information]
Anggono, V., Smillie, K., Graham, M., Valova, V., Cousin, M., Robinson, P. (2006). Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Nature Neuroscience, 9(6), 752-760. [More Information]

2005

Chircop (nee Fabbro), M., Zhou, B., Takahashi, M., Sarcevic, B., Lal, P., Graham, M., Gabrielli, B., Robinson, P., Nigg, E., Ono, Y., et al (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental Cell, 9(4), 477-488. [More Information]
Hill, T., O'dell, L., Edwards, J., Graham, M., McGeachie, A., Rusak, J., Quan, A., Abagyan, R., Scott, J., Robinson, P., et al (2005). Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins. Journal of Medicinal Chemistry, 48(24), 7781-7788. [More Information]

2004

Larsen, M., Graham, M., Robinson, P., Roepstorff, P. (2004). Improved Detection Of Hydrophilic Phosphopeptides Using Graphite Powder Microcolumns And Mass Spectrometry: Evidence For In Vivo Doubly Phosphorylated Dynamin I And Dynamin Iii. Molecular and Cellular Proteomics, 3(5), 456-465. [More Information]
Graham, M., Ruma-Haynes, P., Capes-Davis, A., Dunn, J., Tan, T., Valova, V., Robinson, P., Jeffrey, P. (2004). Multisite Phosphorylation Of Doublecortin By Cyclin-Dependent Kinase 5. Biochemical Journal, 381(2), 471-481. [More Information]
Xue, J., Milburn, P., Hanna, B., Graham, M., Rostas, J., Robinson, P. (2004). Phosphorylation Of Septin 3 On Ser-91 By Cgmp-Dependent Protein Kinase-I In Nerve Terminals. Biochemical Journal, 381(3), 753-760. [More Information]

2003

Tan, T., Valova, V., Malladi, C., Graham, M., Berven, L., Jupp, O., Hansra, G., McClure, S., Sarcevic, B., Boadle, R., Robinson, P., et al (2003). Cdk5 is essential for synaptic vesicle endocytosis. Nature Cell Biology, 5(8), 701-710. [More Information]

Selected Grants

2022

RTTomics: Towards developing new treatments and therapies for Rett syndrome using cortical brain organoids, Gold W, Gonzalez Cordero A, Ellaway C, Graham M, Tolun A, Gloss B, Pang C, Department of Health and Aged Care (Federal - administered by NHMRC)/MRFF - 2022 Effective Treatments and Therapies
Integrative omics: A novel approach to unravelling the complex panoramic landscape of Rett syndrome, Gold W, Graham M, Luminesce Alliance/Enabling Platforms Innovation Fund

2021

ALPK1 dysfunction: revealing a novel pathogenic pathway in retinal diseases, Jamieson R, Graham M, McCluskey P, Grigg J, National Health and Medical Research Council (NHMRC)/Ideas Grant

2017

PYROXD1 - A novel myopathy disease gene identifies a redox pathway essential for life, Cooper S, Tam P, Tam P, Graham M, Graham M, National Health and Medical Research Council (NHMRC)/Project Grants

2014

Phosphatase regulators mediate long-term changes in presynaptic terminals, Graham M, Robinson P, National Health and Medical Research Council (NHMRC)/Project Grants
To investigate the role of ATM protein in protecting against neurodegeneration, Lavin M, Roberts T, Graham M, National Health and Medical Research Council (NHMRC)/Project Grants

2013

Aberrant mesenchymal-epithelial transition: a pathogenic mechanism in tissue maintenance and differentiation, Tam P, Loebel D, Graham M, Arthur J, National Health and Medical Research Council (NHMRC)/Project Grants

2012

Phosphorylation of synaptic vesicle glycoprotein 2 (SV2) regulates endocytosis of synaptotagmin for synaptic transmission, Robinson P, Graham M, National Health and Medical Research Council (NHMRC)/Project Grants

2011

Role of oxidative stress in the human genetic disorder ataxia telangiectasia, Graham M, Lavin M, National Health and Medical Research Council (NHMRC)/Project Grants
A Pilot Study of Pre-synaptic Protein Kinases, Graham M, Robinson P, DVC Research/Bridging Support Grant

2010

Identification of the phospho-regulated synaptic vesicle endocytosis machinery, Graham M, Robinson P, Rebecca L Cooper Medical Research Foundation/Equipment Grant

2009

Inhibitory signaling switches define the machinery of synaptic vesicle endocytosis, Graham M, National Health and Medical Research Council (NHMRC)/Career Development Awards

2008

Mechanisms of synaptic vesicle endocytosis revealed by its regulatory phosphoproteome, Robinson P, Graham M, National Health and Medical Research Council (NHMRC)/Project Grants
Inhibitory signaling switches define the machinery of synaptic vesicle endocytosis, Graham M, DVC Research/Research Fellow Establishment Grants
O-GlcNAc-phosphorylation: a novel post-translational modification regulating vesicle recycling., Graham M, Robinson P, Australian Research Council (ARC)/Discovery Projects (DP)

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Dr Mark Graham

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Selected Grants

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2008