Associate Professor Samantha Fraser-Bell
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Associate Professor Samantha Fraser-Bell

Associate Professor
Faculty of Medicine and Health
Specialty of Clinical Ophthalmology &
Eye Health
Save Sight Institute
Macula Research Group
Associate Professor Samantha Fraser-Bell

Samantha Fraser-Bell is an Associate Professor in the discipline of Ophthalmologyat the University of Sydney. She also consults at Sydney Eye Hospital and Royal North Shore Hospital.

After subspecialty training in Medical Retina and Uveitis at Moorfields Eye Hospital, London UK, she was appointed as a consultant Medical Retina specialist at Sydney Eye Hospital and Medical Retina/Uveitis specialist at Royal North Shore Hospital.Samantha attained her PhD from the University of Sydney in Macula diseases following research at the Doheny Eye Institute, University of Southern California, LA, USA and the Blue Mountains Eye Study and continues to be actively involved inclinicalresearch. Sheruns a weekly research clinic at the Sydney Eye Hospital and the Macula Research Unit, Save Sight institute where she is Deputy Director ofClinicalTrials. Other significant positions held include: Medical Retina Subeditor,Clinical and Experimental Ophthalmology; Member Macula Society; co-Director of Sydney Eye Hospital Medical Retina Fellowship program and Scientific Programme Committee member for the annual RANZCO congress from 2008-2019.

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  • Rhine: A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients With Diabetic Macular Edema2019
  • Lucerne Phase 3 study to evaluate the efficacy and safety of faricimab in participants with neovascular age related macular degeneration.2019
  • OAKS: Phase 3 study to compare the efficacy and safety of intravitreal APL-2 therapy with sham injections in patients with geographic atrophy secondary to age-related macular degeneration
  • GOLDEN: Phase 2 Study to assess safety and efficacy of multiple doses of IONIS-FB-LRx in participants with geographic atrophy secondary to age-related maculardegeneration
  • Renexus Phase 3 CNTF-Secreting cells for treatment of Macular telangiectasia type 2
  • Talon: A 64-week, Two-arm, Randomized, Double-masked, Multicenter, Phase IIIb Study Assessing the Efficacy and Safety of Brolucizumab 6 mg Compared to Aflibercept 2 mg ina Treat-to-control Regimen in Patients With Neovascular Agerelated Macular Degeneration (TALON)
  • Publications

    Book Chapters

    • Mack, H., Hassall, M., Hall, A., Simunovic, M., Fraser-Bell, S., Ayton, L. (2021). Cystoid Macular Edema. In Not known (Eds.), Comprehensive Pharmacology, (pp. 1-37). TBC. [More Information]

    Journals

    • Cozzi, M., Invernizzi, A., Monteduro, D., Esposito, R., Spooner, K., Fraser-Bell, S., Staurenghi, G., Romano, F., Airaldi, M., Chang, A. (2024). Lesion area progression in eyes with neovascular age-related macular degeneration treated using a proactive or a reactive regimen. Eye, 38(1), 161-167. [More Information]
    • Cornish, E., Wickremasinghe, S., Mehta, H., Lim, L., Sandhu, S., Nguyen, V., Gillies, M., Fraser-Bell, S. (2023). Aflibercept monotherapy versus aflibercept with targeted retinal laser to peripheral retinal ischemia for diabetic macular oedema (LADAMO). Eye. [More Information]
    • Mitchell, P., Arnold, J., Fraser-Bell, S., Kang, H., Chang, A., Tainton, J., Simonyi, S. (2023). Dexamethasone intravitreal implant in diabetic macular oedema refractory to anti-vascular endothelial growth factors: The AUSSIEDEX study. BMJ Open Ophthalmology, 8(1). [More Information]

    2024

    • Cozzi, M., Invernizzi, A., Monteduro, D., Esposito, R., Spooner, K., Fraser-Bell, S., Staurenghi, G., Romano, F., Airaldi, M., Chang, A. (2024). Lesion area progression in eyes with neovascular age-related macular degeneration treated using a proactive or a reactive regimen. Eye, 38(1), 161-167. [More Information]

    2023

    • Cornish, E., Wickremasinghe, S., Mehta, H., Lim, L., Sandhu, S., Nguyen, V., Gillies, M., Fraser-Bell, S. (2023). Aflibercept monotherapy versus aflibercept with targeted retinal laser to peripheral retinal ischemia for diabetic macular oedema (LADAMO). Eye. [More Information]
    • Mitchell, P., Arnold, J., Fraser-Bell, S., Kang, H., Chang, A., Tainton, J., Simonyi, S. (2023). Dexamethasone intravitreal implant in diabetic macular oedema refractory to anti-vascular endothelial growth factors: The AUSSIEDEX study. BMJ Open Ophthalmology, 8(1). [More Information]
    • Fraser-Bell, S., Kang, H., Mitchell, P., Arnold, J., Tainton, J., Simonyi, S. (2023). Dexamethasone intravitreal implant in treatment-naïve diabetic macular oedema: findings from the prospective, multicentre, AUSSIEDEX study. British Journal of Ophthalmology, 107(1), 72-78. [More Information]

    2022

    • Niedzwiecki, M., Hunt, A., Nguyen, V., Mehta, H., Creuzot-Garcher, C., Gabrielle, P., Guillemin, M., Fraser-Bell, S., Arnold, J., McAllister, I., Gillies, M., Barthelmes, D. (2022). 12-month outcomes of ranibizumab versus aflibercept for macular oedema in central retinal vein occlusion: data from the FRB! registry. Acta Ophthalmologica, 100(4), e920-e927. [More Information]
    • Shah, J., Nguyen, V., Hunt, A., Mehta, H., Romero-Nuñez, B., Zarranz-Ventura, J., Viola, F., Bougamha, W., Barnes, R., Barthelmes, D., Gillies, M., Fraser-Bell, S. (2022). Characterization of Poor Visual Outcomes of Diabetic Macular Edema: The Fight Retinal Blindness! Project. Ophthalmology Retina, 6(7), 540-547. [More Information]
    • Gabrielle, P., Nguyen, V., Bhandari, S., Mehta, H., Viola, F., Arnold, J., Fraser-Bell, S., Barthelmes, D., Creuzot-Garcher, C., Gillies, M. (2022). Initial observation or treatment for diabetic macular oedema with good visual acuity: two-year outcomes comparison in routine clinical practice: data from the Fight Retinal Blindness! Registry. Acta Ophthalmologica, 100(3), 285-294. [More Information]

    2021

    • Mack, H., Fraser-Bell, S. (2021). "COVID new normal" in ophthalmology: Implications for ophthalmologists, eye care, ophthalmic education and research. Clinical and Experimental Ophthalmology, 49(1), 9-11. [More Information]
    • Paez-Escamilla, M., Jhingan, M., Gallagher, D., Singh, S., Fraser-Bell, S., Chhablani, J. (2021). Age-related macular degeneration masqueraders: From the obvious to the obscure. Survey of Ophthalmology, 66(2), 153-182. [More Information]
    • Bartimote, C., Fraser-Bell, S., Dunn, H. (2021). Asymptomatic occlusive retinal vasculitis in newly diagnosed active tuberculosis. Respiratory Medicine Case Reports, 33, 101456. [More Information]

    2020

    • Busch, C., Okada, M., Zur, D., Fraser-Bell, S., Rodríguez-Valdés, P., Cebeci, Z., Lupidi, M., Fung, A., Gabrielle, P., Giancipoli, E., et al (2020). Baseline predictors for visual acuity loss during observation in diabetic macular oedema with good baseline visual acuity. Acta Ophthalmologica, 98(7), e801-e806. [More Information]
    • Biechl, A., Bhandari, S., Nguyen, V., Arnold, J., Young, S., Fraser-Bell, S., Mehta, H., Gillies, M., Barthelmes, D. (2020). Changes in real-world treatment patterns for diabetic macular oedema from 2009 to 2019 and 5-year outcomes: Data from the Fight Retinal Blindness! Registry. Clinical and Experimental Ophthalmology, 48(6), 802-812. [More Information]
    • Zur, D., Iglicki, M., Sala-Puigdollers, A., Chhablani, J., Lupidi, M., Fraser-Bell, S., Mendes, T., Chaikitmongkol, V., Cebeci, Z., Dollberg, D., Invernizzi, A., et al (2020). Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant. Acta Ophthalmologica, 98(2), e217-e223. [More Information]

    2019

    • Busch, C., Iglicki, M., Okada, M., Gabrielle, P., Cohen, S., Mariussi, M., Amphornphruet, A., Cebeci, Z., Chaikitmongkol, V., Couturier, A., Fraser-Bell, S., Fung, A., et al (2019). Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study. Ophthalmologica, 241(4), 211-219. [More Information]
    • Spooner, K., Hong, T., Fraser-Bell, S., Chang, A. (2019). Current Outcomes of Anti-VEGF Therapy in the Treatment of Macular Edema Secondary to Central Retinal Vein Occlusions: A Systematic Review and Meta-Analysis. Asia-Pacific Journal of Ophthalmology, 8(3), 236-246. [More Information]
    • Spooner, K., Hong, T., Fraser-Bell, S., Chang, A. (2019). Current Outcomes of Anti-VEGF Therapy in the Treatment of Macular Oedema Secondary to Branch Retinal Vein Occlusions: A Meta-Analysis. Ophthalmologica, 242(3), 163-177. [More Information]

    2018

    • Leung, V., Weaver, T., Fraser-Bell, S., Roberts, T. (2018). Acute retinopathy and loss of vision following routine cataract surgery. Clinical and Experimental Ophthalmology, 47(2), 294-296. [More Information]
    • Mehta, H., Hennings, C., Gillies, M., Nguyen, V., Campain, A., Fraser-Bell, S. (2018). Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema. Cochrane Database of Systematic Reviews, 2018 (4), 1-70. [More Information]
    • Hui, M., Raniga, A., Fraser-Bell, S., Salem, W., Clement, C. (2018). Comparison of ICare tonometry to Goldmann tonometry for the measurement of intraocular pressure changes following intravitreal anti-vascular endothelial growth factor injection. Clinical and Experimental Ophthalmology, 46(7), 821-823. [More Information]

    2017

    • Fraser-Bell, S., Symes, R., Vaze, A. (2017). Hypertensive eye disease: a review. Clinical and Experimental Ophthalmology, 45(1), 45-53. [More Information]
    • Wickremasinghe, S., Fraser-Bell, S., Alessandrello, E., Mehta, H., Gillies, M., Lim, L. (2017). Retinal vascular calibre changes after intravitreal bevacizumab or dexamethasone implant treatment for diabetic macular oedema. British Journal of Ophthalmology, 101(10), 1329-1333. [More Information]

    2016

    • Fraser-Bell, S., Lim, L., Campain, A., Mehta, H., Aroney, C., Bryant, J., Li, J., Quin, G., McAllister, I., Gillies, M. (2016). Bevacizumab or Dexamethasone Implants for DME: 2-year Results (The BEVORDEX Study). Ophthalmology, 123(6), 1399-1401. [More Information]
    • Mehta, H., Gillies, M., Fraser-Bell, S. (2016). Combination of vascular endothelial growth factor inhibitors and laser therapy for diabetic macular oedema: a review. Clinical and Experimental Ophthalmology, 44(4), 335-339. [More Information]
    • Mehta, H., Fraser-Bell, S., Yeung, A., Campain, A., Lim, L., Quin, G., McAllister, I., Keane, P., Gillies, M. (2016). Efficacy of dexamethasone versus bevacizumab on regression of hard exudates in diabetic maculopathy: Data from the BEVORDEX randomised clinical trial. British Journal of Ophthalmology, 100(7), 1000-1004. [More Information]

    2015

    • Mehta, H., Fraser-Bell, S., Campain, A., Gillies, M. (2015). Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema. The Cochrane Library Chichester UK: John Wiley and Sons Ltd, 2015 (3). [More Information]
    • Wong, E., Fraser-Bell, S., Hunyor, A., Chen, F. (2015). Novel optical coherence tomography classification of torpedo maculopathy. Clinical and Experimental Ophthalmology, 43(4), 342-348. [More Information]
    • Au, C., Fardell, N., Williams, M., Fraser-Bell, S., Campain, A., Gillies, M. (2015). Patient experiences in retinal trials: a cross-sectional study. BMC Ophthalmology, 15(1), 1-7. [More Information]

    2014

    • Gillies, M., Lim, L., Campain, A., Quin, G., Salem, W., Li, J., Goodwin, S., Aroney, C., McAllister, I., Fraser-Bell, S. (2014). A Randomized Clinical Trial of Intravitreal Bevacizumab versus Intravitreal Dexamethasone for Diabetic Macular Edema: The BEVORDEX Study. Ophthalmology, 121(12), 2473-2481. [More Information]
    • Vaze, A., Fraser-Bell, S., Gillies, M. (2014). Consequences of long-term discontinuation of vascular endothelial growth factor inhibitor therapy in the patients with neovascular age-related macular degeneration. Acta Ophthalmologica, 92(8), e697-e698. [More Information]
    • Fraser-Bell, S. (2014). Preventing vision loss from advanced age-related macular degeneration. Clinical and Experimental Ophthalmology, 42(5), 409-410. [More Information]

    2013

    • Liew, G., Quin, G., Gillies, M., Fraser-Bell, S. (2013). Central serous chorioretinopathy: a review of epidemiology and pathophysiology. Clinical and Experimental Ophthalmology, 41(2), 201-214. [More Information]
    • Quin, G., Liew, G., Ho, I., Gillies, M., Fraser-Bell, S. (2013). Diagnosis and interventions for central serous chorioretinopathy: review and update. Clinical and Experimental Ophthalmology, 41(2), 187-200. [More Information]
    • Karim, R., Sykakis, E., Lightman, S., Fraser-Bell, S. (2013). Interventions for the treatment of uveitic macular edema: a systematic review and meta analysis. Clinical Ophthalmology, 7, 1109-1144. [More Information]

    2012

    • Rajendram, R., Fraser-Bell, S., Kaines, A., Michaelides, M., Hamilton, R., Degli Esposti, S., Peto, T., Egan, C., Bunce, C., Leslie, R., et al (2012). A 2-Year Prospective Randomized Controlled Trial of Intravitreal Bevacizumab or Laser Therapy (BOLT) in the Management of Diabetic Macular Edema: 24-Month Data: Report 3. Archives of Ophthalmology, 130(8), 972-979. [More Information]
    • Salem, W., Fraser-Bell, S., Gillies, M. (2012). Clinical development of new treatments for diabetic macular oedema. Clinical and Experimental Optometry, 95(3), 297-305. [More Information]

    2011

    • Fung, A., Azar, D., Fraser-Bell, S., McCluskey, P., Grigg, J. (2011). Ockham's razor revisited: Decreased visual acuity secondary to keratoconus in a patient with intracranial hypertension. BMJ Case Reports, 2011 (17 February 2011). [More Information]
    • Atan, D., Fraser-Bell, S., Plskova, J., Kuffova, L., Hogan, A., Tufail, A., Kilmartin, D., Forrester, J., Bidwell, J., Dick, A., et al (2011). Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. Investigative Ophthalmology and Visual Science, 52(6), 3573-3581. [More Information]
    • Fraser-Bell, S., Gillies, M. (2011). Retinal conditions - Part 1. Australian Doctor, 22, 27-32.

    2010

    • Michaelides, M., Kaines, A., Hamilton, R., Fraser-Bell, S., Rajendram, R., Quhill, F., Boos, C., Xing, W., Egan, C., Peto, T., et al (2010). A prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (BOLT study) 12-month data: report 2. Ophthalmology, 117(6), 1078-1086. [More Information]
    • Atan, D., Fraser-Bell, S., Plskova, J., Kuffova, L., Hogan, A., Tufail, A., Kilmartin, D., Forrester, J., Bidwell, J., Dick, A., et al (2010). Cytokine polymorphism in noninfectious uveitis. Investigative Ophthalmology and Visual Science, 51(8), 4133-4142. [More Information]
    • Michaelides, M., Fraser-Bell, S., Hamilton, R., Kaines, A., Egan, C., Bunce, C., Peto, T. (2010). Macular perfusion determined by fundus fluorescein angiography at the 4-month time point in a prospective randomized trial of intravitreal bevacizumab or laser therapy in the management of diabetic macular edema (Bolt Study): Report 1. Retina, 30(5), 781-786. [More Information]

    2009

    • Hooper, C., Lamoureux, E., Lim, L., Fraser-Bell, S., Yeoh, J., Harper, C., Keeffe, J., Guymer, R. (2009). Cataract surgery in high-risk age-related macular degeneration: A randomized controlled trial. Clinical and Experimental Ophthalmology, 37(6), 570-576. [More Information]

    2008

    • Fraser-Bell, S., Pavesio, C. (2008). Advances in the treatment of intermediate and posterior uveitis. Expert Review of Ophthalmology, 3(4), 449-456. [More Information]
    • Fraser-Bell, S., Wu, J., Klein, R., Azen, S., Hooper, C., Foong, A., Varma, R. (2008). Cardiovascular risk factors and age-related macular degeneration: the Los Angeles Latino Eye Study. American Journal of Ophthalmology, 145(2), 308-316. [More Information]
    • Fraser-Bell, S., Kaines, A., Hykin, P. (2008). Update on treatments for diabetic macular edema. Current Opinion in Ophthalmology, 19(3), 185-189. [More Information]

    2007

    • Fung, A., Fraser-Bell, S., Ojaimi, E., Sutton, G. (2007). In vivo confocal microscopy and polarizing microscopy of the cornea in a patient with nephropathic cystinosis. Clinical and Experimental Ophthalmology, 35, 292-293. [More Information]

    2006

    • Hooper, C., Fraser-Bell, S., Farinelli, A., Grigg, J. (2006). Complicated hyphaema: think sickle. Clinical and Experimental Ophthalmology, 34(4), 377-378. [More Information]
    • Fraser-Bell, S., Wu, J., Klein, R., Azen, S., Varma, R., Latino Eye Study Group, L. (2006). Smoking, Alcohol Intake, Estrogen Use, and Age-related Macular Degeneration in Latinos: the Los Angeles Latino Eye Study. American Journal of Ophthalmology, 141(1), 79-87. [More Information]

    2005

    • De Moura, C., Fraser-Bell, S., Stout, A., Labree, L., Nilfors, M., Varma, R. (2005). Experience with the Baerveldt glaucoma implant in the management of pediatric glaucoma. American Journal of Ophthalmology, 139(5), 847-854. [More Information]
    • Shufelt, C., Fraser-Bell, S., Ying-Lai, M., Torres, M., Varma, R., Los Angeles Latino Eye Study Group, -. (2005). Refractive error, ocular biometry, and lens opalescence in an adult population: The Los Angeles Latino Eye Study. Investigative Ophthalmology and Visual Science, 46(12), 4450-4460. [More Information]
    • Fraser-Bell, S., Donofrio, J., Wu, J., Klein, R., Azen, S., Varma, R., Los Angeles Latino Eye Study Group, -. (2005). Sociodemographic factors and age-related macular degeneration in Latinos: The Los Angeles Latino Eye Study. American Journal of Ophthalmology, 139(1), 30-38. [More Information]

    2004

    • Fraser-Bell, S., Ying-Lai, M., Klein, R., Varma, R., Los Angeles Latino Eye Study Group, -. (2004). Prevalence and Associations of Epiretinal Membranes in Latinos: The Los Angeles Latino Eye Study. Investigative Ophthalmology and Visual Science, 45(6), 1732-1736. [More Information]
    • Varma, R., Fraser-Bell, S., Tan, S., Klein, R., Azen, S., Los Angeles Latino Eye Study Group, -. (2004). Prevalence of age-related macular degeneration in Latinos: The Los Angeles Latino eye study. Ophthalmology, 111(7), 1288-1297. [More Information]

    2003

    • Guzowski, M., Fraser-Bell, S., Rochtchina, E., Wang, J., Mitchell, P. (2003). Asymmetric refraction in an older population: the Blue Mountains Eye Study. American Journal of Ophthalmology, 136(3), 551-553. [More Information]
    • Fraser-Bell, S., Varma, R. (2003). Eye Disease in Latinos. International Ophthalmology Clinics, 43(4), 79-89. [More Information]
    • Fraser-Bell, S., Guzowski, M., Rochtchina, E., Wang, J., Mitchell, P. (2003). Five-year cumulative incidence and progression of epiretinal membranes. Ophthalmology, 110(1), 34-40. [More Information]

    Selected Grants

    2020

    • Near-infrared Light Photobiomodulation Treatment for RetinalVein Occlusion Macular Oedema NIRVO, Cornish E, Fraser-Bell S, Ophthalmic Research Institute of Australia (ORIA)/ORIA Priming Grant

    2016

    • Phase 4, open-label, non-randomized, prospective study of OZURDEX in the Treatment of Diabetic Macular Oedema - The AUSSIEDEX Study Owner: Save Sight, Fraser-Bell S, IQVIA RDS Pty. Limited/Research Support