Paper in Neuroscience and Biobehavioral Reviews
  • Seigers, R. and J. E. Fardell (2011). Neurobiological basis of chemotherapy-induced cognitive impairment: A review of rodent research. Neuroscience and Biobehavioral Reviews, 35(3): 729-741.

    For some cancer survivors chemotherapy treatment is associated with 
    lasting cognitive impairment, long after treatment cessation. Several 
    candidate mechanisms have been suggested, yet clinical research has 
    been unable to clearly tease apart these hypotheses. Rodent research 
    has allowed a systematic study of these underlying mechanisms in the 
    absence of potential patient confounds. Herein, this research is 
    reviewed with emphasis on the role of the blood-brain barrier, 
    neurogenesis, oxidative stress, white matter, immune system/(neuro) 
    inflammation, HPA axis, blood flow, and cancer in chemotherapy-induced 
    cognitive impairment. Furthermore, potential pharmacotherapy and 
    behavioral intervention strategies are reviewed. This paper ends with 
    methodological considerations in study of chemotherapy and cognition